Basic Information

Faculty

• 薬学部

Concurrent Affiliation

• Graduate School of Pharmaceutical Sciences, professor

Professional Memberships

• From Apr. 2002, To Present

  日本薬学会
• 日本生物物理学会会員 日本蛋白質科学会会員
• 日本結晶学会会員 日本分子生物学会会員 日本農芸化学会会員

Academic Degree

• Master of Agriculture(Yamagata University)
• Doctor of Agriculture(Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, 大学院農学研究科博士後期課程, 修了
• Yamagata University, 大学院農学研究科修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 山形大学, 農学部農芸化学科, 卒業

High School

• High School

  青森県立八戸高等学校

Research History

• From Apr. 2002, To Present

  京都大学大学院薬学研究科、教授
• From Apr. 2002, To Mar. 2006

  チームリーダーを兼任
• From Oct. 1999, To Mar. 2006

  理化学研究所・速度論的結晶学研究チーム・チームリーダー
• From 1989, To Sep. 1999

  同大学文部教官 助手
• From May 1988, To Feb. 1989

  Kyoto University, Institute for Chemical Research
• From Apr. 1988, To May 1988

  Kyoto University, Institute for Chemical Research

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-5993-4532

• J-Global ID

  200901081803394944

• External link

  http://www.pharm.kyoto-u.ac.jp/kato/index.html

researchmap URL

• https://researchmap.jp/read0095441

Research

Research Topics, Overview of the research

• Research Topics

  Structural Pharmacology of Multi-drug transporters

• Overview of the research

  Understanding the mechanism of multidrug transporters is crucial for designing drugs of good bioavailability and efficient cancer chemotherapy. Thus, we try to elucidate their three-dimensional structures and some dynamic structures during their works by structural pharmacology approaches based on new generation X-ray crystallography. Those structures will allow us to unveil pharmacologic behavior of the transporters, especially to solve the ambivalent issue in controlling multi-drug transporters.

Research Interests

• Basic medical sciences
• Structural pharmacology
• Structural Biology
• Stractural Biology

Research Areas

• Life sciences, Biophysics
• Life sciences, Pharmaceuticals - analytical and physicochemistry
• Life sciences, Applied biochemistry
• Life sciences, Structural biochemistry

Papers

• Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors.

  Aoi Takahara; Toru Nakatsu; Kazushige Hirata; Hironori Hayashi; Kumi Kawaji; Keisuke Aoki; Shinsuke Inuki; Hiroaki Ohno; Hiroaki Kato; Eiichi Kodama; Shinya Oishi

  Journal of medicinal chemistry, 13 Feb. 2025

  
• [Frontiers of Physical Pharmaceutical Research by Young Scientists Making Breakthroughs (Symposium of Division of Physical Sciences)].

  Hiroaki Kato; Mikako Ogawa

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2024

  
• Structure-ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1.

  Sorachi Miwa; Hiroshi Takikawa; Rina Takeuchi; Ryo Mizunuma; Keita Matsuoka; Haruo Ogawa; Hiroaki Kato; Kiyosei Takasu

  ACS medicinal chemistry letters, 08 Feb. 2024, Peer-reviewed

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• [The First 5-year Integrated Doctoral Program Exploring the Frontiers of Pharmaceutical Sciences].

  Hiroaki Kato

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2023, Peer-reviewed, Invited, Lead author

  
• Structure‐based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy

  Yoshiki Inoue; Tomohiro Yamaguchi; Tetsuo Otsuka; Yuto Utsunomiya; Dongqing Pan; Haruo Ogawa; Hiroaki Kato

  Protein Science, Jun. 2022, Peer-reviewed, Last author, Corresponding author

  
• Structure Biology of Peroxisomal Proteins, Peroxins

  Hiroaki Kato

  Peroxisomes: Biogenesis, Function, and Role in Human Disease, 2019, Lead author, Last author, Corresponding author

  
• Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX

  Dongqing Pan; Ryo Oyama; Tomomi Sato; Takanori Nakane; Ryo Mizunuma; Keita Matsuoka; Yasumasa Joti; Kensuke Tono; Eriko Nango; So Iwata; Toru Nakatsu; Hiroaki Kato

  IUCrJ, 01 Jan. 2022, Peer-reviewed, Last author, Corresponding author

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• The crystal structure of the CmABCB1 G132V mutant, which favors the outward‐facing state, reveals the mechanism of the pivotal joint between TM1 and TM3

  Keita Matsuoka; Toru Nakatsu; Hiroaki Kato

  Protein Science, May 2021, Last author, Corresponding author

  
• ABCB1/MDR1/P‐gp employs an ATP‐dependent twist‐and‐squeeze mechanism to export hydrophobic drugs

  Atsushi Kodan; Ryota Futamata; Yasuhisa Kimura; Noriyuki Kioka; Toru Nakatsu; Hiroaki Kato; Kazumitsu Ueda

  FEBS Letters, Mar. 2021

  
• Structural and functional diversity calls for a new classification of ABC transporters.

  Christoph Thomas; Stephen G Aller; Konstantinos Beis; Elisabeth P Carpenter; Geoffrey Chang; Lei Chen; Elie Dassa; Michael Dean; Franck Duong Van Hoa; Damian Ekiert; Robert Ford; Rachelle Gaudet; Xin Gong; I Barry Holland; Yihua Huang; Daniel K Kahne; Hiroaki Kato; Vassilis Koronakis; Christopher M Koth; Youngsook Lee; Oded Lewinson; Roland Lill; Enrico Martinoia; Satoshi Murakami; Heather W Pinkett; Bert Poolman; Daniel Rosenbaum; Balazs Sarkadi; Lutz Schmitt; Erwin Schneider; Yigong Shi; Show-Ling Shyng; Dirk J Slotboom; Emad Tajkhorshid; D Peter Tieleman; Kazumitsu Ueda; András Váradi; Po-Chao Wen; Nieng Yan; Peng Zhang; Hongjin Zheng; Jochen Zimmer; Robert Tampé

  FEBS letters, Dec. 2020

  
• Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Matsuoka; Yasuhisa Kimura; Kazumitsu Ueda; Hiroaki Kato

  Nature Communications, 08 Jan. 2019, Peer-reviewed, Last author, Corresponding author

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• Structure-based Relationship between the color of firefly luminescence and the enzyme-substrate interaction

  Kazuki Io; Tomohiro Yamaguchi; Tomohiro Murai; Auto Utsunomiya; Hiroaki Onishi; Ka Lu; Toru Nakatsu; Hiroaki Kato

  ELCAS Journal, Mar. 2017, Peer-reviewed

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• Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography

  Yamashita, K.; Kuwabara, N.; Nakane, T.; Murai, T.; Mizohata, E.; Sugahara, M.; Pan, D.; Masuda, T.; Suzuki, M.; Sato, T.; Kodan, A.; Yamaguchi, T.; Nango, E.; Tanaka, T.; Tono, K.; Joti, Y.; Kameshima, T.; Hatsui, T.; Yabashi, M.; Manya, H.; Endo, T.; Kato, R.; Senda, T.; Kato, H.; Iwata, S.; Ago, H.; Yamamoto, M.; Yumoto, F.; Nakatsu, T.

  IUCrJ, 2017, Peer-reviewed

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• Crystal Structure of Eukaryotic P-glycoprotein Homolog from Cyanidioschyzon merolae

  YAMAGUCHI Tomohiro; KATO Hiroaki

  Seibutsu Butsuri, Nov. 2016, Peer-reviewed, Invited

  
• Mechanism for the Transport of ABC Transporters by Experimental and Simulation Studies

  FURUTA Tadaomi; YAMAGUCHI Tomohiro; KATO Hiroaki; SAKURAI Minoru

  Seibutsu Butsuri, Jan. 2016, Peer-reviewed

  
• ヒトABC多剤排出トランスポーター類似タンパク質の立体構造決定と新規阻害剤の創製

  KATO HIROAKI

  ファルマシア, 01 Apr. 2015

  
• Motion tree delineates hierarchical structure of protein dynamics observed in molecular dynamics simulation

  Moritsugu, K.; Koike, R.; Yamada, K.; Kato, H.; Kidera, A.

  PLoS ONE, 2015, Peer-reviewed

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• Synthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors

  Watanabe, B.; Ichiyanagi, A.; Hirokawa, K.; Gomi, K.; Nakatsu, T.; Kato, H.; Kajiyama, N.

  Bioorganic and Medicinal Chemistry Letters, 2015, Peer-reviewed

  
• An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography

  Yamashita, K.; Pan, D.; Okuda, T.; Sugahara, M.; Kodan, A.; Yamaguchi, T.; Murai, T.; Gomi, K.; Kajiyama, N.; Mizohata, E.; Suzuki, M.; Nango, E.; Tono, K.; Joti, Y.; Kameshima, T.; Park, J.; Song, C.; Hatsui, T.; Yabashi, M.; Iwata, S.; Kato, H.; Ago, H.; Yamamoto, M.; Nakatsu, T.

  Scientific Reports, 2015, Peer-reviewed

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• Structure and Mechanism of a Eukaryotic ABC Multidrug Transporter

  KODAN Atsushi; YAMAGUCHI Tomohiro; NAKATSU Toru; KATO Hiroaki

  X-RAYS, 31 Aug. 2014

  
• Expression and purification of a GRAS domain of SLR1, the rice della protein

  Sato, T.; Miyanoiri, Y.; Takeda, M.; Naoe, Y.; Mitani, R.; Hirano, K.; Takehara, S.; Kainosho, M.; Matsuoka, M.; Ueguchi-Tanaka, M.; Kato, H.

  Protein Expression and Purification, 2014, Peer-reviewed, Last author, Corresponding author

  
• Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

  Kodan, A.; Yamaguchi, T.; Nakatsu, T.; Sakiyama, K.; Hipolito, C.J.; Fujioka, A.; Hirokane, R.; Ikeguchi, K.; Watanabe, B.; Hiratake, J.; Kimura, Y.; Suga, H.; Ueda, K.; Kato, H.

  Proceedings of the National Academy of Sciences of the United States of America, 2014, Peer-reviewed, Last author, Corresponding author

  
• Analysis of the structural and functional roles of coupling helices in the ATP-binding cassette transporter MsbA through Enzyme assays and molecular dynamics simulations

  Furuta, T.; Yamaguchi, T.; Kato, H.; Sakurai, M.

  Biochemistry, 2014, Peer-reviewed

  
• Crystal structures of β-primeverosidase in complex with disaccharide amidine inhibitors

  Saino, H.; Shimizu, T.; Hiratake, J.; Nakatsu, T.; Kato, H.; Sakata, K.; Mizutani, M.

  Journal of Biological Chemistry, 2014, Peer-reviewed

  
• Crystallization and preliminary crystallographic analysis of two eukaryotic fructosyl peptide oxidases

  Ichiyanagi, A.; Hirokawa, K.; Gomi, K.; Nakatsu, T.; Kato, H.; Kajiyama, N.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2013, Peer-reviewed

  
• Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p

  Pan, D.; Nakatsu, T.; Kato, H.

  Nature Structural and Molecular Biology, 2013, Peer-reviewed, Last author, Corresponding author

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• 細胞の分子構造と機能―核以外の細胞小器官 5.ペルオキシソーム ペルオキシソーム膜タンパク質

  KATO HIROAKI

  生体の科学, 15 Oct. 2012

  
• 細胞の分子構造と機能―核以外の細胞小器官 5.ペルオキシソーム ペルオキシソーム膜タンパク質Pex3pとサイトソルタンパク質Pex19p複合体の三次元構造

  KATO HIROAKI

  生体の科学, 15 Oct. 2012

  
• Structural basis for color modulation mechanism of firefly luciferase bioluminescence

  Terakado Kanako; Yoshimune Ryosuke; Gomi Keiko; Kajiyama Naoki; Ikeuchi Hideyuki; Hiratake Jun; Kato Hiroaki; Nakatsu Toru

  LUMINESCENCE, Mar. 2012, Peer-reviewed

  
• ナノバイオ技術と最新創薬応用研究 第1章 ナノバイオ創薬に向けたターゲットの探索と構造解析 3.トランスポーターの構造生物学的研究とナノバイオ創薬

  KATO HIROAKI; NAKATSU TOORU; YAMAGUCHI TOMOHIRO

  遺伝子医学MOOK, 31 Jan. 2012

  
• Crystallization and preliminary X-ray crystallographic analysis of Pz peptidase B from Geobacillus collagenovorans MO-1

  Nakano, H.; Hosokawa, A.; Tagawa, R.; Inaka, K.; Ohta, K.; Nakatsu, T.; Kato, H.; Watanabe, K.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012, Peer-reviewed

  
• Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p

  Yasuhiko Sato; Hiroyuki Shibata; Toru Nakatsu; Hiroaki Nakano; Yoshinori Kashiwayama; Tsuneo Imanaka; Hiroaki Kato

  EMBO JOURNAL, Dec. 2010, Peer-reviewed, Last author, Corresponding author

  
• Gibberellin Receptor GID1 : Gibberellin Recognition and Molecular Evolution

  KATO Hiroaki; SATO Tomomi; UEGUCHI TANAKA Miyako

  X-RAYS, 28 Feb. 2010

  
• The exquisite structure and reaction mechanism of bacterial Pz-peptidase a toward collagenous peptides: X-ray crystallographic structure analysis of Pz-peptidase a reveals differences from mammalian thimet oligopeptidase

  Kawasaki, A.; Nakano, H.; Hosokawa, A.; Nakatsu, T.; Kato, H.; Watanabe, K.

  Journal of Biological Chemistry, 2010, Peer-reviewed

  
• Deleting two C-terminal α-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP

  Terakado, K.; Kodan, A.; Nakano, H.; Kimura, Y.; Ueda, K.; Nakatsu, T.; Kato, H.

  Acta Crystallographica Section D: Biological Crystallography, 2010, Peer-reviewed, Last author, Corresponding author

  
• Development of innovative methods to support crystallization of eukaryotic membrane proteins: crystallizability-based target selection using GFP fusion technique and folding-controlled protein expression in methylotrophic yeast

  加藤 博章; 山下 敦子; 江川 響子

  Protein, nucleic acid and enzyme, Sep. 2009

  
• X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution

  Watabe, T.; Terakawa, Y.; Watanabe, K.; Ohno, H.; Nakano, H.; Nakatsu, T.; Kato, H.; Izumi, K.; Kodama, E.; Matsuoka, M.; Kitaura, K.; Oishi, S.; Fujii, N.

  Journal of Molecular Biology, 2009, Peer-reviewed

  
• Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells

  Kodan, A.; Shibata, H.; Matsumoto, T.; Terakado, K.; Sakiyama, K.; Matsuo, M.; Ueda, K.; Kato, H.

  Protein Expression and Purification, 2009, Peer-reviewed, Last author, Corresponding author

  
• Overexpression and purification of rat peroxisomal membrane protein 22, PMP22, in Pichia pastoris

  Egawa, K.; Shibata, H.; Yamashita, S.-i.; Yurimoto, H.; Sakai, Y.; Kato, H.

  Protein Expression and Purification, 2009, Peer-reviewed, Last author, Corresponding author

  
• Selective labeling of tag-fused protein by tryptophan-sensitized luminescence of a terbium complex

  Hirayama, T.; Taki, M.; Kodan, A.; Kato, H.; Yamamoto, Y.

  Chemical Communications, 2009, Peer-reviewed

  
• Functional role of the linker region in purified human P-glycoprotein

  Sato, T.; Kodan, A.; Kimura, Y.; Ueda, K.; Nakatsu, T.; Kato, H.

  FEBS Journal, 2009, Peer-reviewed, Last author, Corresponding author

  
• Mechanism of efficient firefly bioluminescence via adiabatic transition state and seam of sloped conical intersection

  Lung, W.C.; Hayashi, S.; Lundberg, M.; Nakatsu, T.; Kato, H.; Morokuma, K.

  Journal of the American Chemical Society, 2008, Peer-reviewed

  
• Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: Identification of TRP-104 in Pex3p as a critical residue for the interaction

  Sato, Y.; Shibata, H.; Nakano, H.; Matsuzono, Y.; Kashiwayama, Y.; Kobayashi, Y.; Fujiki, Y.; Imanaka, T.; Kato, H.

  Journal of Biological Chemistry, 2008, Peer-reviewed, Last author, Corresponding author

  
• Structural basis for gibberellin recognition by its receptor GID1

  Shimada, A.; Ueguchi-Tanaka, M.; Nakatsu, T.; Nakajima, M.; Naoe, Y.; Ohmiya, H.; Kato, H.; Matsuoka, M.

  Nature, 2008, Peer-reviewed

  
• Color control mechanism of firefly glowing: crystal structure and mechanism of luminescent enzyme luciferase

  加藤 博章; 中津 亨

  京都大学低温物質科学研究センター誌, Dec. 2007

  
• 蛍光タンパク質の創成 ルシフェラーゼの立体構造の解明

  KATO HIROAKI; NAKATSU TOORU

  別冊化学, 25 Apr. 2007

  
• Control Mechanism for Bioluminescent Color of Firefly

  KATO Hiroaki; NAKATSU Toru

  KAGAKU TO SEIBUTSU, 01 Apr. 2007

  
• 目で見るバイオ ホタルの発光は,どうして黄緑色なのか?

  KATO HIROAKI; NAKATSU TOORU

  バイオサイエンスとインダストリー, 01 Mar. 2007

  
• Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

  Kimura, Y.; Kioka, N.; Kato, H.; Matsuo, M.; Ueda, K.

  Biochemical Journal, 2007, Peer-reviewed

  
• New insights into the binding mode of coenzymes: Structure of Thermus thermophilus Δ¹-pyrroline-5-carboxylate dehydrogenase complexed with NADP⁺

  Inagaki, E.; Ohshima, N.; Sakamoto, K.; Babayeva, N.D.; Kato, H.; Yokoyama, S.; Tahirov, T.H.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2007, Peer-reviewed

  
• Crystallization and preliminary X-ray crystallographic studies of Pz peptidase A from Geobacillus collagenovorans MO-1

  Kawasaki, A.; Nakano, H.; Tsujimoto, Y.; Matsui, H.; Shimizu, T.; Nakatsu, T.; Kato, H.; Watanabe, K.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2007, Peer-reviewed

  
• Enigma of firefly glowing

  Kato, H.; Nakatsu, T.

  Seikagaku, 2007, Peer-reviewed, Invited

  
• 構造解析から見えてきたタンパク質の多彩な機能 発光酵素「ルシフェラーゼ」の反応過程の立体構造

  KATO HIROAKI; NAKATSU TOORU

  実験医学, 01 Nov. 2006

  
• Future drug discovery owing to structure analysis of the ABC(ATP-bindingcassette) protein.

  KODAN ATSUSHI; KIMURA YASUHISA; KATO HIROAKI; UEDA KAZUMITSU

  未来材料, 10 Oct. 2006

  
• Structural basis for the spectral difference in luciferase bioluminescence

  Nakatsu, T.; Ichiyama, S.; Hiratake, J.; Saldanha, A.; Kobashi, N.; Sakata, K.; Kato, H.

  Nature, 2006, Peer-reviewed, Last author, Corresponding author

  
• Overexpression, purification, crystallization and preliminary X-ray cystallographic studies of a proline-specific aminopeptidase from Aneurinibacillus sp. strain AM-1

  Akioka, M.; Nakano, H.; Horikiri, A.; Tsujimoto, Y.; Matsui, H.; Shimizu, T.; Nakatsu, T.; Kato, H.; Watanabe, K.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2006, Peer-reviewed

  
• Crystallization and preliminary crystallographic analysis of bacterial fructosyl amino acid oxidase

  Sakaue, R.; Nakatsu, T.; Yamaguchi, Y.; Kato, H.; Kajiyama, N.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2005, Peer-reviewed

  
• Role of Pex19p in the targeting of PMP70 to peroxisome

  Kashiwayama, Y.; Asahina, K.; Shibata, H.; Morita, M.; Muntau, A.C.; Roscher, A.A.; Wanders, R.J.A.; Shimozawa, N.; Sakaguchi, M.; Kato, H.; Imanaka, T.

  Biochimica et Biophysica Acta - Molecular Cell Research, 2005, Peer-reviewed

  
• Expression, purification, and crystallization of endopolygalacturonase from a pathogenic fungus, Stereum purpureum, in Escherichia coli

  Shimizu, T.; Shibata, H.; Araya, T.; Nakatsu, T.; Miyairi, K.; Okuno, T.; Kato, H.

  Protein Expression and Purification, 2005, Peer-reviewed, Last author, Corresponding author

  
• Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid

  Yamamoto, K.; Watanabe, N.; Matsuda, H.; Oohara, K.; Araya, T.; Hashimoto, M.; Miyairi, K.; Okazaki, I.; Saito, M.; Shimizu, T.; Kato, H.; Okuno, T.

  Bioorganic and Medicinal Chemistry Letters, 2005, Peer-reviewed

  
• Structure and function of the PsbP protein of Photosystem II from higher plants

  Ifuku, K.; Nakatsu, T.; Shimamoto, R.; Yamamoto, Y.; Ishihara, S.; Kato, H.; Sato, F.

  Photosynthesis Research, 2005, Peer-reviewed

  
• Crystal structures of pyruvate phosphate dikinase from maize revealed an alternative conformation in the swiveling-domain motion

  Nakanishi, T.; Nakatsu, T.; Matsuoka, M.; Sakata, K.; Kato, H.

  Biochemistry, 2005, Peer-reviewed, Last author, Corresponding author

  
• The purification and characterization of Pex3p and Pex19p involved in peroxisome membrane protein trafficking

  Y Sato; H Shibata; H Nakano; T Imanaka; H Kato

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• Large scale purification of P-glycoprotein from Sf plus insect cells

  Y Kimura; T Nakatsu; H Kato

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• 生体高分子の大きさ,形態,局所構造,物性,リガンド相互作用の測定装置 動的光散乱 (バイオ高性能機器・新技術利用マニュアル) -- (各種解析装置の原理と使用例)

  加藤 博章

  蛋白質核酸酵素, Aug. 2004

  
• Crystal structure of the C-terminal clock-oscillator domain of the cyanobacterial KaiA protein

  T Uzumaki; M Fujita; T Nakatsu; F Hayashi; H Shibata; N Itoh; H Kato; M Ishiura

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Jul. 2004, Peer-reviewed

  
• Reaction Mechanism Based on X-ray Crystallography at Atomic Resolution of Endopolygalacutronase I from Fungus Stereum purpureum

  SHIMIZU Tetsuya; NAKATSU Toru; MIYAIRI Kazuo; OKUNO Toshikatsu; KATO Hiroaki

  Journal of applied glycoscience, 20 Apr. 2004

  
• Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins

  Shibata, H.; Kashiwayama, Y.; Imanaka, T.; Kato, H.

  Journal of Biological Chemistry, 2004, Peer-reviewed, Last author, Corresponding author

  
• Crystal structure of the PsbP protein of photosystem II from Nicotiana tabacum

  Ifuku, K.; Nakatsu, T.; Kato, H.; Sato, F.

  EMBO Reports, 2004, Peer-reviewed

  
• Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin

  Matsubara, M.; Nakatsu, T.; Kato, H.; Taniguchi, H.

  EMBO Journal, 2004, Peer-reviewed

  
• Purification, crystallization and preliminary X-ray diffraction studies on pyruvate phosphate dikinase from maize.

  Nakanishi, T.; Ohki, Y.; Oda, J.; Matsuoka, M.; Sakata, K.; Kato, H.

  Acta crystallographica. Section D, Biological crystallography, 2004, Peer-reviewed, Last author, Corresponding author

  
• Crystal structure of the C-terminal clock-oscillator domain of the cyanobacterial KaiA protein

  Uzumaki, T.; Fujita, M.; Nakatsu, T.; Hayashi, F.; Shibata, H.; Itoh, N.; Kato, H.; Ishiura, M.

  Nature Structural and Molecular Biology, 2004, Peer-reviewed

  
• Localization of a peroxisomal ABC transporter, PMP70 - the role of a chaperone-like protein,Pex19p

  Y Kashiwayama; K Asahina; M Morita; H Shibata; H Kato; T Imanaka

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed

  
• Crystal structure of γ-glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis

  Hibi, T.; Nii, H.; Nakatsu, T.; Kimura, A.; Kato, H.; Hiratake, J.; Oda, J.

  Proceedings of the National Academy of Sciences of the United States of America, 2004, Peer-reviewed

  
• Reaction Mechanism Based on X-ray Crystallography at Atomic Resolution of Endopolygalacutronase I from Fungus Stereum purpureum

  Shimizu Tetsuya; Nakatsu Toru; Miyairi Kazuo; Okuno Toshikatsu; Kato Hiroaki

  Journal of Applied Glycoscience, 2004

  
• Enzyme Structure Prior to Reaction Initiation Capturing with Laue Diffraction and its Reaction Mechanism : Tropinone Reductase-II-Substrate Complexes

  YAMASHITA Atsuko; KATO Hiroaki

  X-RAYS, 25 Dec. 2003

  
• Crystallization and preliminary crystallographic studies on the extrinsic 23 kDa protein in the oxygen-evolving complex of photosystem II

  Ifuku, K.; Nakatsu, T.; Kato, H.; Sato, F.

  Acta Crystallographica - Section D Biological Crystallography, 2003, Peer-reviewed

  
• Capturing enzyme structure prior to reaction initiation: Tropinone reductase-II-substrate complexes

  Yamashita, A.; Endo, M.; Higashi, T.; Nakatsu, T.; Yamada, Y.; Oda, J.; Kato, H.

  Biochemistry, 2003, Peer-reviewed, Last author, Corresponding author

  
• Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca²⁺-calmodulin

  Yamauchi, E.; Nakatsu, T.; Matsubara, M.; Kato, H.; Taniguchi, H.

  Nature Structural Biology, 2003, Peer-reviewed

  
• Structure and binding mode of a ribosome recycling factor (RRF) from mesophilic bacterium

  Nakano, H.; Yoshida, T.; Uchiyama, S.; Kawachi, M.; Matsuo, H.; Kato, T.; Ohshima, A.; Yamaichi, Y.; Honda, T.; Kato, H.; Yamagata, Y.; Ohkubo, T.; Kobayashi, Y.

  Journal of Biological Chemistry, 2003, Peer-reviewed

  
• ダイナミックなタンパク質機能 巨大分子の実時間構造解析

  Galburt Eric A; Stoddard Barry L; 加藤 博章

  パリティ, Jul. 2002

  
• Active-site architecture of endopolygalacturonase I from Stereum purpureum revealed by crystal structures in native and ligand-bound forms at atomic resolution

  Shimizu, T.; Nakatsu, T.; Miyairi, K.; Okuno, T.; Kato, H.

  Biochemistry, 2002, Peer-reviewed, Last author, Corresponding author

  
• Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif

  Irie, K.; Nakatsu, T.; Mitsuoka, K.; Miyazawa, A.; Sobue, K.; Hiroaki, Y.; Doi, T.; Fujiyoshi, Y.; Kato, H.

  Journal of molecular biology, 2002, Peer-reviewed, Last author, Corresponding author

  
• Escherichia coli B γ-glutamylcysteine synthetase: Modification, purification, crystallization and preliminary crystallographic analysis

  Hibi, T.; Hisada, H.; Nakatsu, T.; Kato, H.; Oda, J.

  Acta Crystallographica Section D: Biological Crystallography, 2002, Peer-reviewed

  
• Crystallization and preliminary X-ray crystallographic studies of a mutant of ribosome recycling factor from Escherichia coli, Arg132Gly

  Nakano, H.; Uchiyama, S.; Yoshida, T.; Ohkubo, T.; Kato, H.; Yamagata, Y.; Kobayashi, Y.

  Acta Crystallographica Section D: Biological Crystallography, 2002, Peer-reviewed

  
• ラウエ法を用いた時分割X線結晶構造解析 (新世紀における蛋白質科学の進展) -- (第1部 蛋白質研究方法の進展)

  加藤 博章

  蛋白質核酸酵素, Aug. 2001

  
• Crystallization and preliminary X-ray study of endopolygalacturonase from the pathogenic fungus Stereum purpureum

  Shimizu, T.; Nakatsu, T.; Miyairi, K.; Okuno, T.; Kato, H.

  Acta Crystallographica Section D: Biological Crystallography, 2001, Peer-reviewed, Last author, Corresponding author

  
• アミラーゼの反応中間体がX線結晶解析で捕らえられた ! (2000年の化学(3)第一線化学者による最新のトピックス)

  加藤 博章

  化学, Mar. 2000

  
• Crystal structure of tobacco PR-5d protein at 1.8 angstrom resolution reveals a conserved acidic cleft structure in antifungal thaumatin-like proteins

  H Koiwa; H Kato; T Nakatsu; J Oda; Y Yamada; F Sato

  JOURNAL OF MOLECULAR BIOLOGY, Mar. 1999, Peer-reviewed

  
• A potent transition-state analogue inhibitor of Escherichia coli asparagine synthetase A

  Koizumi, M.; Hiratake, J.; Nakatsu, T.; Kato, H.; Oda, J.

  Journal of the American Chemical Society, 1999, Peer-reviewed

  
• Structure of tropinone reductase-II complexed with NADP⁺ and pseudotropine at 1.9 Å resolution: Implication for stereospecific substrate binding and catalysis

  Yamashita, A.; Kato, H.; Wakatsuki, S.; Tomizaki, T.; Nakatsu, T.; Nakajima, K.; Hashimoto, T.; Yamada, Y.; Oda, J.

  Biochemistry, 1999, Peer-reviewed

  
• Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductases

  Nakajima, K.; Kato, H.; Oda, J.; Yamada, Y.; Hashimoto, T.

  Journal of Biological Chemistry, 1999, Peer-reviewed

  
• Crystal structure of tobacco PR-5d protein at 1.8 Å resolution reveals a conserved acidic cleft structure in antifungal thaumatin-like proteins

  Koiwa, H.; Kato, H.; Nakatsu, T.; Oda, J.; Yamada, Y.; Sato, F.

  Journal of Molecular Biology, 1999, Peer-reviewed

  
• Calcium ion-dependent reactivation of a Pseudomonas lipase by its specific modulating protein, LipB

  Shibata, H.; Kato, H.; Oda, J.

  Journal of Biochemistry, 1998, Peer-reviewed

  
• Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase

  Nakatsu, T.; Kato, H.; Oda, J.

  Nature Structural Biology, 1998, Peer-reviewed

  
• Crystallization and preliminary cristallographic study of tropinone reductase II from Datura stramonium

  Yamashita, A.; Nakajima, K.; Kato, H.; Hashimoto, T.; Yamada, Y.; Oda, J.

  Acta Crystallographica Section D: Biological Crystallography, 1998, Peer-reviewed

  
• Molecular properties and activity of amino-terminal truncated forms of lipase activator protein

  Shibata, H.; Kato, H.; Oda, J.

  Bioscience, Biotechnology and Biochemistry, 1998, Peer-reviewed

  
• Random mutagenesis on the Pseudomonas lipase activator protein, LipB: Exploring amino acid residues required for its function

  Shibata, H.; Kato, H.; Oda, J.

  Protein Engineering, 1998, Peer-reviewed

  
• Design, synthesis and evaluation of transition-state analogue inhibitors of Escherichia coli γ-glutamylcysteine synthetase

  Tokutake, N.; Hiratake, J.; Katoh, M.; Irie, T.; Kato, H.; Oda, J.

  Bioorganic and Medicinal Chemistry, 1998, Peer-reviewed

  
• Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold

  Nakajima, K.; Yamashita, A.; Akama, H.; Nakatsu, T.; Kato, H.; Hashimoto, T.; Oda, J.; Yamada, Y.

  Proceedings of the National Academy of Sciences of the United States of America, 1998, Peer-reviewed

  
• Supporting Strategies of Protein Crystallization by Dynamic Light Scattering

  KATO Hiroaki

  X-RAYS, Aug. 1997, Peer-reviewed

  
• Four-dimensional structure of enzyme:Watching enzyme at work by time-resolved X-ray crystallography

  KATO Hiroaki; ODA Jun'ichi

  Bioscience & industry, 01 Jul. 1997

  
• Purification and characterization of tobacco pathogenesis-related protein PR-5d, an antifungal thaumatin-like protein

  Koiwa, H.; Kato, H.; Nakatsu, T.; Oda, J.; Yamada, Y.; Sato, F.

  Plant and Cell Physiology, 1997, Peer-reviewed

  
• 国際学会報告 : いまタンパク質結晶学はどうなっている....第17回国際結晶学連合大会に出席して

  加藤 博章

  日本農藝化學會誌, Dec. 1996

  
• DSC Study on the Themal Unfolding of Glutathione Synthetase from Escherichia coli B

  FUKADA Harumi; TAKAHASHI Katsutada; KATO Hiroaki; ODA Jun'ichi

  Calorimetry and thermal analysis., 01 Oct. 1996

  
• 抗菌性タバコオスモチン様タンパク質(OLP)の結晶化 : 植物

  小岩 尚志; 加藤 博章; 中津 亨; 西岡 孝明; 小田 順一; 山田 康之; 佐藤 文彦

  日本農藝化學會誌, 05 Mar. 1996

  
• リパーセ活性化タンパク質Lib : ランダム変異導入法による変異体の取得 : 物理化学・分析化学

  柴田 洋之; 加藤 博章; 小田 順一

  日本農藝化學會誌, 05 Mar. 1996

  
• Organic Chemistry and Protein Crystallography Probing Enzyme Mechanisms with Transition State Analogs

  KATO Hiroaki; ODA Jun'ichi

  X-RAYS, 28 Feb. 1996

  
• Organic Chemistry and Protein Crystallography Probing Enzyme Mechanisms with Transition State Analogs

  KATO Hiroaki; ODA Jun'ichi

  X-RAYS, Feb. 1996

  
• A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: Structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 Å resolution

  Hara, T.; Kato, H.; Katsube, Y.; Oda, J.

  Biochemistry, 1996, Peer-reviewed

  
• Mechanism-based inactivation of E. coli γ-glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues

  Katoh, M.; Hiratake, J.; Kato, H.; Oda, J.

  Bioorganic and Medicinal Chemistry Letters, 1996, Peer-reviewed

  
• Structure of the multifunctional loops in the nonclassical ATP-binding fold of glutathione synthetase

  Hibi, T.; Nishioka, T.; Kato, H.; Tanizawa, K.; Fukui, T.; Katsube, Y.; Oda, J.

  Nature Structural Biology, 1996, Peer-reviewed

  
• Crystallization and preliminary crystallographic study of asparagine synthetase from Escherichia coli

  Nakatsu, T.; Kato, H.; Oda, J.

  Acta Crystallographica Section D: Biological Crystallography, 1996, Peer-reviewed

  
• Crystal structure of glutathione synthetase at optimal pH: Domain architecture and structural similarity with other proteins

  Matsuda, K.; Mizuguchi, K.; Nishioka, T.; Kato, H.; Go, N.; Oda, J.

  Protein Engineering, 1996, Peer-reviewed

  
• DSC Study on the Thermal Unfolding of Glutathione Synthetase from Escherichia coli B.

  Fukada Harumi; Takahashi Katsutada; Kato Hiroaki; Oda Jun'ichi

  Netsu Sokutei, 1996

  
• 呼吸鎖膜酵素の分子構造にメスーシトクロムＣ酸化酵素のＸ線結晶構造解析ー

  加藤 博章

  蛋白質核酸酵素,40/ . 2340-2341, 1995

  
• Site-directed mutagenesis of glutathione synthetase from Escherichia coli b: Mapping of the γ-l-glutamyl-l-cysteine-binding site

  Hara, T.; Tanaka, T.; Kato, H.; Nishioka, T.; Oda, J.

  Protein Engineering, Design and Selection, 1995, Peer-reviewed

  
• グルタチオン合成酵素のX線結晶構造解析

  加藤 博章

  日本農藝化學會誌, 01 Dec. 1994

  
• タンパク質の動きやすい部分を見る--X線結晶構造解析を中心に

  加藤 博章; 小田 順一

  化学と生物, Jul. 1994

  
• Mechanism-Based Inactivation of Glutathione Synthetase by Phosphinic Acid Transition-State Analog

  Hiratake, J.; Kato, H.; Oda, J.

  Journal of the American Chemical Society, 1994, Peer-reviewed

  
• Flexible Loop That Is Novel Catalytic Machinery in a Ligase. Atomic Structure and Function of the Loopless Glutathione Synthetase

  Kato, H.; Tanaka, T.; Hara, T.; Nishioka, T.; Oda, J.; Yamaguchi, H.; Katsube, Y.

  Biochemistry, 1994, Peer-reviewed

  
• 酵素反応の原子レベルでの映像化 (1994年の化学-1-)

  加藤 博章; 小田 順一

  化学, Jan. 1994

  
• 蛋白質の動きやすい部分を見る－Ｘ線結晶構造解析を中心に－

  加藤 博章

  化学と生物,32/7, 428-433, 1994

  
• STRUCTURE AND FUNCTION OF GLUTATHIONE SYNTHETASE FROM ESCHERICHIA-COLI-B

  Y KATSUBE; H YAMAGUCHI; H KATO; T HIBI; T TANAKA; T NISHIOKA; J ODA

  SYNCHROTRON RADIATION IN THE BIOSCIENCES, 1994, Peer-reviewed

  
• Visualization of Mobile Regions in Proteins by X-Ray Crystallography.

  KATO Hiroaki; ODA Jun'ichi

  KAGAKU TO SEIBUTSU, 1994

  
• 酵素反応の原子レベルでの映像化 (1994年の化学-1-)

  加藤 博章; 小田 順一

  化学, Jan. 1994

  
• Crystallographic studies of glutathione synthetase

  Kato, H.

  Nippon Nogeikagaku Kaishi, 1994

  
• Flexibility Impaired by Mutations Revealed the Multifunctional Roles of the Loop in Glutathione Synthetase

  Tanaka, T.; Yamaguchi, H.; Kato, H.; Nishioka, T.; Katsube, Y.; Oda, J.

  Biochemistry, 1993, Peer-reviewed

  
• Use of Adenosine(5′)polyphospho(5′)pyridoxals To Study the Substrate-Binding Region of Glutathione Synthetase from Escherichia coli B

  Hibi, T.; Kato, H.; Nishioka, T.; Oda, J.; Yamaguchi, H.; Katsube, Y.; Tanizawa, K.; Fukui, T.

  Biochemistry, 1993, Peer-reviewed

  
• Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 Å resolution

  Yamaguchi, H.; Kato, H.; Hata, Y.; Nishioka, T.; Kimura, A.; Oda, J.; Katsube, Y.

  Journal of Molecular Biology, 1993, Peer-reviewed

  
• Mutational and Proteolytic Studies on a Flexible Loop in Glutathione Synthetase from Escherichia Coli B: The Loop and Arginine 233 are Critical for the Catalytic Reaction

  Tanaka, T.; Kato, H.; Nishioka, T.; Oda, J.

  Biochemistry, 1992, Peer-reviewed

  
• Overexpression and Purification of Asparagine Synthetase from Escherichia coli

  Sugiyama, A.; Kato, H.; Nishioka, T.; Oda, J.

  Bioscience, Biotechnology and Biochemistry, 1992, Peer-reviewed

  
• Structural and functional aspects for the active site of glutathione synthetase

  Kato, H.; Oda, J.

  Seikagaku. The Journal of Japanese Biochemical Society, 1992

  
• Ｌｏｏｐ構造：酵素における新しい機能性構造単位

  加藤博章

  バイオサイエンスとインダストリー, Aug. 1991

  
• Loop構造--酵素における新しい機能性構造単位

  加藤 博章

  バイオサイエンスとインダストリ-, Aug. 1991

  
• Recent Progress in the Structure of CN-bond Ligases

  Kato, H.; Oda, J.

  Nippon Nogeikagaku Kaishi, 1991

  
• PURIFICATION AND PROPERTIES OF PHENOLOXIDASE FROM SPINACH LEAVES

  Y ODA; H KATO; Y ISODA; N TAKAHASHI; T YAMAMOTO; Y TAKADA; S KUDO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Aug. 1989, Peer-reviewed

  
• Crystallization and preliminary X-ray studies of glutathione synthetase from Escherichia coli B

  Kato, H.; Yamaguchi, H.; Hata, Y.; Nishioka, T.; Katsube, Y.; Oda, J.

  Journal of Molecular Biology, 1989, Peer-reviewed

  
• Overexpression of Glutathione Synthetase in Escherichia Coli

  Kato, H.; Kobayashi, M.; Murata, K.; Nishioka, T.; Ada, J.

  Agricultural and Biological Chemistry, 1989, Peer-reviewed

  
• Role of cysteine residues in glutathione synthetase from Escherichia coli B. Chemical modification and oligonucleotide site-directed mutagenesis

  Kato, H.; Tanaka, T.; Nishioka, T.; Kimura, A.; Oda, J.

  Journal of Biological Chemistry, 1988, Peer-reviewed

  
• Homology of Escherichia coli b glutathione synthetase with dihydrofolate reductase in amino acid sequence and substrate binding site

  Kato, H.; Chihara, M.; Nlshioka, T.; Murata, K.; Kimura, A.; Oda, J.

  Journal of Biochemistry, 1987, Peer-reviewed

  
• A PRACTICAL SYNTHESIS OF SEVERAL POLYHYDROXYLATED CHIRAL BUILDING-BLOCKS

  M KUSAKABE; H KATO; F SATO

  CHEMISTRY LETTERS, 1987, Peer-reviewed

  

Misc.

• High Resolution X-ray Crystallographic Analysis of Flippase-type ABC Transporter

  Sato Yasuhiro; Miyake Yutaro; Hipolito Christopher J.; Yamaguchi Tomohiro; Nakatsu Toru; Suga Hiroaki; Kato Hiroaki

  SPring-8/SACLA Research Report, 21 Jul. 2015

  
• Construction, Expression, and Characterization of Glutathione Synthetase Chimeras : Substitution of a Loop with a Homologous Peptide Region of Dihydrofolate Reductase (Commemoration Issue Dedicated to Professor Mituru Takanami On the Occasion of His Retirement)

  Tanaka, Takuji; Sakai, Tetsuya; Chihara-Siomi, Mikiko; Takeshima, Kazuya; Kato, Hiroaki; Misawa, Takako; Hashimoto, Tomoko; Nishioka, Takaaki; Oda, Jun'ichi

  Bulletin of the Institute for Chemical Research, Kyoto University, 29 Oct. 1993

  
• 物理系薬学部会：薬学の基礎から応用までを網羅する科学研究コミュニティ

  加藤 博章

  ファルマシア, 2023

  
• 心筋型リアノジン受容体の構造解析-カフェインによる活性化機構の解明に向けて

  大鳥祐矢; 加藤博章; 加藤博章; 小川治夫

  次世代を担う若手のためのフィジカル・ファーマフォーラム講演要旨集, 2023

  
• X-ray Crystallographic Analysis of Luciferase:oxyakalumine:AMP Complex

  中津亨; 田中義明; 加藤博章

  SPring-8/SACLA利用研究成果集(Web), 2023, Peer-reviewed

  
• クライオ電顕による一回膜貫通型受容体NPR-Bの機能構造解析

  近藤瞳; 児玉昌美; 加藤博章; 加藤博章; 小川治夫

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2023

  
• Drug-binding affinity of ABC transporter in phospholipid bilayer or detergent micelle

  相良優介; 水沼諒; 小川治夫; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2023

  
• Multidrug-recognition mechanism of ABC transporter by X-ray crystallography

  水沼諒; 小田島圭; 三和空知; 瀧川紘; 高須清誠; 小川治夫; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2023

  
• Cryo-EM single particle analysis of Candida albicans Cdr1p multi-drug ABC transporter

  PAN Dongqing; 筒井隼一; 宮田知子; 牧野文信; 牧野文信; 難波啓一; 小川治夫; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2022

  
• Structual analysis of human GC-B receptor extracellular domain by cryo-EM

  近藤瞳; 美濃拓実; 児玉昌美; 加藤博章; 加藤博章; 小川治夫

  日本薬学会年会要旨集(Web), 2022

  
• Analysis of ligand recognition mechanism by guanylate cyclase recetor

  美濃拓実; 近藤瞳; 児玉昌美; 加藤博章; 加藤博章; 小川治夫

  日本薬学会年会要旨集(Web), 2022

  
• The role of multidrug transporter CmABCB1 residues in drug transport based on crystal structure

  水沼諒; PAN Dongqing; 小川治夫; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2022

  
• Cryo-EM structure of ABC multidrug tranporter

  坂口俊平; 水沼諒; 小川治夫; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2022

  
• ABCトランスポーターとの共結晶形成を指向したローダミン誘導体の合成と評価

  三和空知; 瀧川紘; 竹内莉奈; 小田島圭; 水沼諒; 山岡庸介; 潘東青; 加藤博章; 高須清誠

  次世代を担う有機化学シンポジウム講演要旨集, 2022

  
• Structural analysis of the GC-B receptor in complex with CNP

  美濃拓実; 近藤瞳; 児玉昌美; 加藤博章; 小川治夫

  日本生体エネルギー研究会討論会講演要旨集, 2022

  
• クライオ電子顕微鏡によるABC多剤排出トランスポーターと基質複合体の単粒子構造解析

  坂口俊平; 水沼諒; 宮田知子; 牧野文信; 牧野文信; 難波啓一; 小川治夫; 加藤博章; 加藤博章

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2022

  
• Structure-based design and optimization of novel measles virus fusion inhibitors

  山口夕貴; 高原葵; 青木啓輔; 青木啓輔; 中津亨; 中津亨; 平田和成; 鈴木聡志; 林宏典; 河治久実; 井貫晋輔; 大野浩章; 加藤博章; 村山和隆; 児玉栄一; 大石真也; 大石真也

  メディシナルケミストリーシンポジウム講演要旨集, 2022

  
• Inhibitory activity of the specific binding peptide against P-glycoprotein CmABCB1 in nanodisc

  CHEN Yue; PAN Dongqing; 筒井隼一; 菅裕明; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2020

  
• Affinity-labeling of the poly-specific substrate binding site in P-glycoprotein, CmABCB1

  小田島圭; PAN Dongqing; 三和空知; 水沼諒; 瀧川紘; 高須清誠; 加藤博章; 加藤博章

  日本薬学会年会要旨集(CD-ROM), 2020

  
• X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant

  WATABE Tsuyoshi; OISHI Shinya; WATANABE Kentaro; OHNO Hiroaki; NAKANO Hiroaki; NAKATSU Toru; KATO Hiroaki; IZUMI Kazuki; KODAMA Eiichi; MATSUOKA Masao; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Mechanism-Based Inactivation of Glutathione Synthetase by Phosphinic Acid Transition-State Analogue (MOLECULAR BIOFUNCTION - Functional Molecular Conversion)

  Hiratake Jun; Kato Hiroaki; Oda Jun'ichi

  ICR annual report, Mar. 1995

  Access this misc :

  
• CRYSTALLIZATION OF TOBACCO OSMOTIN-LIKE PROTEIN.

  KOIWA Hisashi; KATO Hiroaki; NAKATSU Ryou; NISHIOKA Takaaki; ODA Junichi; YAMADA Yasuyuki; SATO Fumihiko

  Plant and cell physiology, Mar. 1996

  
• ROLE OF N-TERMINAL 18 AMINO-ACID RESIDUES OF OEC23 IN PS II FOR ION RETENTION :

  IFUKU Kentaro; NAKATSU Toru; KATO Hiroaki; SATO Fumihiko

  Plant and cell physiology, 2001

  
• Identification of substrate binding sites in P-glycoprotein, CmABCB1 with affinity-labeling

  小田島圭; PAN Dongqing; 三和空知; 水沼諒; 瀧川紘; 高須清誠; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2021

  
• ABC多剤排出トランスポーター薬物複合体のX線結晶構造解析

  水沼諒; 小田島圭; 三和空知; 潘東青; 瀧川紘; 中津亨; 中津亨; 高須清誠; 加藤博章; 加藤博章

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2021

  
• Potent Transition-State Analogue Inhibitor of Esherichia coli Asparagine Synthetase A (MOLECULAR BIOFUNCTION-Functional Molecular Conversion)

  Hiratake Jun; Koizumi Mitsuteru; Nakatsu Toru; Kato Hiroaki; Oda Jun'ichi

  ICR annual report, Mar. 2000

  Access this misc :

  
• Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold. (MOLECULAR BIOFUNCTION-Functional Molecular Conversion)

  Nakajima Keiji; Yamashita Atsuko; Akama Hiroyuki; Nakatsu Toru; Kato Hiroaki; Hashimoto Takashi; Oda Jun'ichi; Yamada Yasuyuki

  ICR annual report, Mar. 1999

  Access this misc :

  
• Crystal Structure of Asparagine Synthetase Reveals a Close Evolutionary Relationship to Class II Aminoacyl-tRNA Synthetase (MOLECULAR BIOFUNCTION-Functional Molecular Conversion)

  Nakatsu Toru; Kato Hiroaki; Oda Jun'ichi

  ICR annual report, Mar. 1998

  Access this misc :

  
• Crystal structure of multidrug transporter CmABCB1 and substrate analogs

  水沼諒; 小田島圭; 三和空知; PAN Dongqing; 瀧川紘; 中津亨; 中津亨; 高須清誠; 加藤博章; 加藤博章

  日本薬学会年会要旨集(Web), 2021

  
• Purification and biochemical characterization of Candida albicans Cdr1p multi-drug exporter.

  筒井隼一; CHEN Yue; 中津亨; 中津亨; 加藤博章; 加藤博章; PAN Dongqing

  日本薬学会年会要旨集(Web), 2021

  
• The Ca²⁺-binding photoprotein aequorin stabilizes a peroxidized state

  船橋俊也; 南後恵理子; 南後恵理子; 岩田想; 岩田想; 加藤博章; 加藤博章; 中津亨; 中津亨

  日本薬学会年会要旨集(Web), 2021

  
• Synthesis and structure-ATPase activity relationship of rhodamine derivatives against P-glycoprotein CmABCB1

  瀧川紘; 三和空知; 竹内莉奈; 山岡庸介; PAN Dongqing; 中津亨; 加藤博章; 高須清誠

  複素環化学討論会講演要旨集, 2020

  
• Structure-ATPase activity relationship of rhodamine derivatives as transport substrates for P-glycoprotein CmABCB1

  瀧川紘; 三和空知; 山岡庸介; 山口知宏; 中津亨; 加藤博章; 高須清誠

  日本薬学会年会要旨集(CD-ROM), 2020

  
• Functional investigation of transmembrane helix 4 of thermophilic P-glycoprotein CmABCB1

  水沼諒; 井上善貴; 松岡敬太; Pan Dongqing; 中津亨; 中津亨; 加藤博章; 加藤博章

  日本薬学会年会要旨集(CD-ROM), 2020

  
• ATP binding cassette transporter,CmABCB1を含有したナノディスクの調製

  陳月; 山口知宏; 中津亨; 加藤博章

  日本細胞生物学会大会(Web), 2019

  
• Reconstitution of an ATP binding cassette transporter, CmABCB1 into nano disc

  Chen, Y; Yamaguchi, T; Nakatsu, T; Kato, H

  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会, Jun. 2019

  
• Trp経口を利用したP糖タンパク質分子内の基質結合部位の解析

  井上善貴; 山口知宏; 大城悠暉; 松岡敬太; 加藤博章

  日本薬学会第139年会・講演要旨集, Mar. 2019

  
• トリプトファンの蛍光を利用した ABC 多剤排出トランスポーターとリガンドとの相互作用解析

  大城悠暉; 山口知宏; 松岡敬太; 宇都宮裕人; 中津亨; 加藤博章

  第67回日本薬学会近畿支部総会・大会, Oct. 2017

  
• P糖タンパク質の基質排出ゲート開閉の構造基盤

  松岡敬太; 山口知宏; 中津亨; 中津亨; 加藤博章; 加藤博章

  日本蛋白質科学会年会プログラム・要旨集, Jun. 2017

  
• X線自由電子レーザーを用いたP糖タンパク質ホモログの連続フェムト秒X線結晶構造解析

  大山諒; 潘東青; 中津亨; 佐藤友美; 山口知宏; 小段篤史; 植田和光; 岩田想; 加藤博章

  第14回次世代を担う若手のためのフィジカル・ファーマフォーラム（PPF2016）, Aug. 2016

  
• メタノール資化性酵母発現系を用いて¹⁵N安定同位体標識したABCトランスポーターのNMR解析

  宇都宮裕人; 山口知宏; 宮ノ入洋平; 小田健人; 中津亨; 甲斐荘正恒; 加藤博章

  日本蛋白質科学会年会プログラム・要旨集, 19 May 2016

  
• [ε‐¹³C]メチオニン標識したABCトランスポーターMsbAの調製とNMR解析

  小田健人; 山口知宏; 宮ノ入洋平; 盧そう; 宇都宮裕人; 中津亨; 甲斐荘正恒; 加藤博章

  日本蛋白質科学会年会プログラム・要旨集, 19 May 2016

  
• ヌクレオチド依存的なATP感受性カリウムチャンネルの構造変化

  木村泰久; 菅野亮; 松尾道憲; 加藤博章; 光岡薫; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2016

  
• X線自由電子レーザーを用いた新規タンパク質の立体構造決定

  山下恵太郎; 潘東青; 奥田智彦; 菅原道泰; 小段篤史; 山口知宏; 村井智洋; 溝端栄一; 鈴木守; 南後恵理子; 登野健介; 城地保昌; 亀島敬; 初井宇記; 矢橋牧名; 岩田想; 岩田想; 加藤博章; 加藤博章; 吾郷日出夫; 山本雅貴; 中津亨; 中津亨

  日本薬学会年会要旨集(CD-ROM), Mar. 2016

  
• Serial Femtosecond Crystallography of ABC Transporter

  Oyama, R; Pan, D; Nakatsu, T; Sato, T; Yamaguchi, T; Kodan, A; Ueda, K; Iwata. S; Kato, H

  6th Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases (ABC2016), Mar. 2016

  
• Crystallographic study of the ABC transporter CmABCB1 covalently bound to substrate derivatives

  Matsuoka, K; Hirokane, R; Kodan, A; Yamaguchi, T; Nakatsu, T; Ueda, K; Kato, H

  6th Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases (ABC2016), Mar. 2016

  
• To Our Dear Readers: Greetings from the Chairman of the ELCAS Journal Editorial Committee

  加藤 博章

  ELCAS Journal, Mar. 2016

  Access this misc :

  
• Structural pharmacology for receptors and transporters

  Shimizua, T.; Kato, H.

  Yakugaku Zasshi, 2016

  
• 真核生物由来ABC輸送体の分子機構

  小段篤史; 植田和光; 加藤博章

  日本生化学会大会(Web), 2016

  
• Altering stability of a transmembrane protein, MsbA by structural comparison with its thermophilic homolog

  K. Lu; T. Yamaguchi; T. Nakatsu; H. Kato

  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem2015), Dec. 2015

  
• シリアル結晶学における重原子誘導体を用いた位相決定

  山下恵太郎; 潘東青; 長谷川和也; 菅原道泰; 村井智洋; 小段篤史; 溝端栄一; 鈴木守; 鈴木守; 桝田哲哉; 桝田哲哉; 平田邦生; 加藤博章; 加藤博章; 吾郷日出夫; 熊坂崇; 山本雅貴; 中津亨; 中津亨

  日本結晶学会年会講演要旨集, 17 Oct. 2015

  
• NMR解析を目指したABCトランスポーターの大腸菌高密度培養による安定同位体標識系の確立

  小田健人; 山口知宏; 宮ノ入洋平; 中津 亨; 甲斐荘正恒; 加藤博章

  日本薬学会近畿支部総会・大会, Oct. 2015

  
• フルクトシルペプチドオキシダーゼの界面活性剤耐性向上

  鉞陽介; 一柳敦; 中津亨; 加藤博章; 五味恵子

  日本生物工学会大会講演要旨集, 25 Sep. 2015

  
• プロテアーゼを必要としないHbA1c測定法の開発

  一柳敦; 鉞陽介; 渡辺文太; 中津亨; 加藤博章; 五味恵子

  日本生物工学会大会講演要旨集, 25 Sep. 2015

  
• ヒトMDR1の基質取り込みゲート機構の解析

  末永健人; 井上修一; 木村泰久; 木岡紀幸; 加藤博章; 植田和光

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• フルクトシルペプチドオキシダーゼによるN^α‐(1‐deoxy‐D‐fructos‐1‐yl)‐L‐valyl‐L‐histidine酸化反応の構造基盤

  一柳敦; 渡辺文太; 五味恵子; 中津亨; 加藤博章

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• ヒトMDR1の内向き構造安定化機構の検討

  津山智美; 木村泰久; 木岡紀幸; 加藤博章; 植田和光

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• 超好熱菌Pyrococcus horikoshii由来ABCトランスポーターの発現精製および機能解析

  佐藤友美; 佐藤友美; 三歸大知; 中津亨; 加藤博章

  日本生化学会大会(Web), 2015

  
• X線自由電子レーザーを用いたタンパク質X線結晶構造解析

  HAN TOSEI; NAKATSU TOORU; NAKATSU TOORU; YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; OGAWA KAZUHIRO; MATSUSHIMA KAZUKI; YAMASHITA KEITARO; JOUCHI YASUMASA; TONO KENSUKE; YABASHI MAKINA; SUZUKI MAMORU; SUZUKI MAMORU; NANGO ERIKO; IWATA SO; IWATA SO; KATO HIROAKI; KATO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• Trp変異導入によるABC多剤排出トランスポーターと基質の相互作用解析

  OTSUKA TETSUO; YAMAGUCHI TOMOHIRO; NAKATSU TOORU; NAKATSU TOORU; KATO HIROAKI; KATO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• ペルオキシソーム形成におけるタンパク質輸送シグナル認識の構造基盤

  KATO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2015, Invited

  
• 2P-029 Development of protease-free HbA1c measurement method

  Ichiyanagi Atsushi; Masakari Yosuke; Watanabe Bunta; Nakatsu Toru; Kato Hiroaki; Gomi Keiko

  日本生物工学会大会講演要旨集, 2015

  
• 2P-033 Enhancement of detargent resitance of fructosyl peptide oxidase

  Masakari Yosuke; Ichiyanagi Atsushi; Nakatsu Toru; Kato Hiroaki; Gomi Keiko

  日本生物工学会大会講演要旨集, 2015

  
• ABC多剤排出トランスポーターの立体構造の特徴

  山口知宏; 小段篤史; 中津亨; 植田和光; 加藤博章

  第87回日本生化学会大会, 15 Oct. 2014

  
• 測定温度の違いがもたらすタンパク質X線結晶構造への影響

  村井智洋; 潘東青; 小段篤史; 山下恵太郎; 上野剛; 加藤博章; 中津亨

  11 Oct. 2014

  
• Lysの13C-ジメチル化によるABC多剤排出トランスポーターのNMR解析

  宇都宮裕人; 山口知宏; 宮ノ入洋平; 武田光広; 中津亨; 甲斐荘正恒; 加藤博章

  第64回日本薬学会近畿支部総会・大会, Oct. 2014

  
• SACLAによるABCトランスポーターおよびホタル・ルシフェラーゼのX線結晶構造解析

  PAN DONGQING; NAKATSU TOORU; YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; OGAWA KAZUHIRO; MATSUSHIMA KAZUKI; JOUCHI YASUMASA; TONO KENSUKE; YABASHI MAKINA; SUZUKI MAMORU; NANGO ERIKO; IWATA SO; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 26 May 2014

  
• 耐熱性向上型フルクトシルペプチドオキシダーゼの開発

  MASAKARI YOSUKE; ICHIYANAGI ATSUSHI; NAKATSU TOORU; KATO HIROAKI; GOMI KEIKO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• HbA1c由来糖化ヘキサペプチドに作用するフルクトシルペプチドオキシダーゼの開発

  ICHIYANAGI ATSUSHI; MASAKARI YOSUKE; WATANABE BUNTA; NAKATSU TOORU; KATO HIROAKI; GOMI KEIKO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• 精製タンパク質を用いたヒトABCタンパク質の機能解析

  KIMURA YASUHISA; HIRAYAMA HIROSHI; INOUE SHUICHI; TSUYAMA TOMOMI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• ヒトMDR1の輸送基質導入ゲートの解析

  INOUE SHUICHI; KIMURA YASUHISA; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• Crystal structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Sakiyama; Christopher J. Hipolito; Akane Fujioka; Ryo Hirokane; Yasuhisa Kimura; Hiroaki Suga; Kazumitsu Ueda; Hiroaki Kato

  ABC2014, 5th FEBS Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Mar. 2014

  
• Structure-based functional aspects of the ABC multidrug transporter, CmABCB1 from a thermophilic eukaryote

  Tomohiro Yamaguchi; Atsushi Kodan; Toru Nakatsu; Keita Sakiyama; Christopher J. Hipolito; Akane Fujioka; Ryo Hirokane; Yasuhisa Kimura; Hiroaki Suga; Kazumitsu Ueda; Hiroaki Kato

  ABC2014, 5th FEBS Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Mar. 2014

  
• Expression and Purification of a GRAS Domain of Rice GRAS Protein, SLR1, Suitable for Structural Analysis

  Tomomi Sato; Yohei Miyanoiri; Mitsuhiro Takeda; Rie Mitani; Ko Hirano; Masatsune Kainosho; Makoto Matsuoka; Hiroaki Kato; Miyako Ueguchi-Tanaka

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Identification of hydrophobic amino acids involved in substrate recognition of human MDR1

  Tomomi Tsuyama; Yasuhisa Kimura; Noriyuki Kioka; Hiraoki Kato; Kaztumitsu Ueda

  第37回日本分子生物学会, 2014

  
• SACLAによるABCトランスポーターおよびホタル・ルシフェラーゼのX線結晶構造解析(第2報)

  HAN TOSEI; NAKATSU TOORU; YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; OGAWA KAZUHIRO; MATSUSHIMA KAZUKI; YAMASHITA KEITARO; JOUCHI YASUMASA; TONO KENSUKE; YABASHI MAKINA; SUZUKI MAMORU; NANGO ERIKO; IWATA SO; KATO HIROAKI

  日本結晶学会年会講演要旨集, 2014

  
• ATP Binding Cassetteトランスポーターの構造薬理学

  KATO HIROAKI

  日本結晶学会年会講演要旨集, 2014

  
• ABC多剤排出トランスポーターにおける基質取込の立体構造基盤

  YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• ABCトランスポーターのATP加水分解基礎活性の調節部位の探索

  MASHIKO SHO; YAMAGUCHI TOMOHIRO; NAKATSU TOORU; KATO HIROAKI

  生体膜と薬物の相互作用シンポジウム講演要旨集, 21 Nov. 2013

  
• 創薬ターゲット蛋白質の迅速構造解析法の開発~SACLAにおけるシリアルフェムト秒X線結晶構造解析~

  NANGO ERIKO; SUZUKI MAMORU; TANAKA RIE; TONO KENSUKE; JOUCHI YASUMASA; KAMESHIMA TAKASHI; PARK JAEHYUN; SONG CHANGYONG; HATSUI TAKAKI; YABASHI MAKINA; HAN TOSEI; KODAN ATSUSHI; YAMAGUCHI TOMOHIRO; NAKATSU TOORU; KATO HIROAKI; TANAKA YOSHIKI; SUNO CHIYO; IHARA KENTARO; TOYOTA YOSUKE; SHIMAMURA TATSURO; MIZOHATA EIICHI; KITAGO YU; TAKAGI JUN'ICHI; ISHITANI RYUICHIRO; NUREKI OSAMU; GALLAT FRANCOIS-XAVIER; YAMADA YUSUKE; MATSUGAKI NAOHIRO; YUMOTO FUMIAKI; CHAVAS LEONARD M. G; IWATA SO

  日本結晶学会年会講演要旨集, 12 Oct. 2013

  
• 1P037 Roles of two coupling helices between transmembrane and cytosolic domains in ABC transporter(01B. Protein:Structure & Function,Poster)

  Yamaguchi Tomohiro; Jinushi Ryohei; Masuko Sho; Nakatsu Toru; Kato Hiroaki

  Seibutsu Butsuri, Oct. 2013

  
• Improvement of Substrate Specificity of Fructosyl Peptide Oxidase by Structure-Based Mutagenesis

  Ichiyanagi, A; Watanabe, B; Hirokawa, K; Masakari, Y; Gomi, K; Nakatsu, T; Kato, H; Kajiyama, N

  Enzyme Engineering XXII, Toyama, Japan, Sep. 2013

  
• ジスルフィド結合導入によるフルクトシルペプチドオキシダーゼの耐熱性向上

  MASAKARI YOSUKE; ICHIYANAGI ATSUSHI; GOMI KEIKO; NAKATSU TOORU; KATO HIROAKI; KAJIYAMA NAOKI

  日本生物工学会大会講演要旨集, 25 Aug. 2013

  
• 1P-074 Enhancement of thermostability of fructosyl peptide oxidase by introducing disulfide bond

  Masakari Yosuke; Ichiyanagi Atsushi; Gomi Keiko; Nakatsu Toru; Kato Hiroaki; Kajiyama Naoki

  日本生物工学会大会講演要旨集, 25 Aug. 2013

  
• ジベレリンシグナル伝達メカニズムに関与するタンパク質の構造・機能解析

  SATO YUMI; MIYANOIRI YOHEI; TAKEDA MITSUHIRO; MITANI RIE; HIRANO KO; TAKEHARA SAYAKA; NOMOTO MIKA; TADA YASUOMI; KAINOSHO MASATSUNE; MATSUOKA MAKOTO; KATO HIROAKI; UEKUCHI(TANAKA) MIYAKO

  日本植物細胞分子生物学会大会・シンポジウム講演要旨集, 20 Aug. 2013

  
• 好熱性真核生物のABC多剤排出トランスポーターのX線結晶構造解析

  HIROKANE RYO; KODAN ATSUSHI; NAKATSU TOORU; YAMAGUCHI TOMOHIRO; UEDA KAZUMITSU; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 31 May 2013

  
• 糖尿病診断に適したFructosyl peptide oxidaseの開発

  ICHIYANAGI ATSUSHI; MASAKARI YOSUKE; WATANABE BUNTA; HIROKAWA KOZO; GOMI KEIKO; NAKATSU TOORU; KATO HIROAKI

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• ジベレリン生合成酵素の構造解析への試み

  TAKEHARA SAYAKA; MORINAKA YOICHI; KATO HIROAKI; MATSUOKA MAKOTO; UEGUCHI(TANAKA) MIYAKO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• X-Ray crystallography of an ABC multi-drug transporter from a thermophilic eukaryote

  T. Yamaguchi; H. Kato

  Symposium on Hydration and ATP Energy 2013, Mar. 2013

  
• ヒトMDR1の第4,第10膜貫通ヘリックスの基質導入ゲートとしての機能の解析

  INOUE SHUICHI; KIMURA YASUHISA; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• 単粒子解析によるATP感受性カリウムチャネルのサブユニット構造決定

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; KATO HIROAKI; MITSUOKA KAORU; UEDA KAZUMITSU

  日本生化学会大会(Web), 2013

  
• ヒトMDR1の基質結合部位に存在する芳香族アミノ酸の解析

  TSUYAMA TOMOMI; KIMURA YASUHISA; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• 好熱性紅藻由来ABCトランスポーターの輸送基質特異性の検討

  YAMAGUCHI TOMOHIRO; KIMURA YASUHISA; KODAN ATSUSHI; IKEGUCHI KEIJI; WATANABE BUNTA; HIRATAKE JUN; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  生体膜と薬物の相互作用シンポジウム講演要旨集, 15 Nov. 2012

  
• Fructosyl peptide oxidaseとN^ε‐(1‐deoxy‐D‐fructos‐1‐yl)‐L‐lysineアナログ複合体のX線結晶構造解析

  ICHIYANAGI ATSUSHI; WATANABE BUNTA; HIROKAWA KOZO; GOMI KEIKO; NAKATSU TOORU; KATO HIROAKI; KAJIYAMA NAOKI

  日本生物工学会大会講演要旨集, 25 Sep. 2012

  
• 3Cp08 Crystal structure of fructosyl peptide oxidase in complex with N^ε-(1-deoxy-D-fructos-1-yl)-L-lysine analog

  Ichiyanagi Atsushi; Watanabe Bunta; Hirokawa Kozo; Gomi Keiko; Nakatsu Toru; Kato Hiroaki; Kajiyama Naoki

  日本生物工学会大会講演要旨集, 25 Sep. 2012

  
• トランスポーターにおけるATP駆動力共役メカニズムの立体構造基盤

  山口知宏; 小段篤史; 中津亨; 藤岡あかね; 植田和光; 加藤博章

  公開シンポジウム「ゆらぎと水―生命のエネルギーと機能の分子機構を探る」, Sep. 2012

  
• 結晶構造に基づく多剤排出型ABCトランスポーターメカニズムの解明

  FUJIOKA AKANE; YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  次世代を担う若手ファーマ・バイオフォーラム講演要旨集, Sep. 2012

  
• 分子動力学シミュレーションによるABCトランスポーターMsbAにおけるカップリング・ヘリックス変異の構造的影響

  FURUTA TADAOMI; YAMAGUCHI TOMOHIRO; KATO HIROAKI; SAKURAI MINORU

  日本蛋白質科学会年会プログラム・要旨集, 31 May 2012

  
• 多剤排出型ABCトランスポーターのX線結晶構造解析

  KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• Coniochaeta sp.NISL9330由来Fructosyl peptide oxidaseの基質特異性の改変

  ICHIYANAGI ATSUSHI; GOMI KEIKO; NAKATSU TOORU; KATO HIROAKI

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• ヒト培養細胞を用いた哺乳類膜タンパク質大量生産系―K_ATPチャネル複合体の精製―

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; KIOKA NORIYUKI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• X-ray crystallographic analysis of an exporter-type ABC transporter

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Sakiyama; Akane Fujioka; Kazumitsu Ueda; Hiroaki Kato

  ABC2012, the 4th FEBS Special Meeting “ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease” Hotel Grauer Bär (Innsbruck, Austria), Mar. 2012

  
• Single particle analysis of KATP channel complex

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  日本顕微鏡学会 第６８回研究会, 2012

  
• ABCトランスポーターにおけるATP駆動メカニズムの立体構造基盤

  KATO HIROAKI

  日本生体エネルギー研究会討論会講演要旨集, 2012

  
• 好熱性真核生物由来の多剤排出型ABCトランスポーターのX線結晶構造解析

  KATO HIROAKI

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• ATP感受性カリウムチャネル複合体の精製と単粒子解析によるサブユニット構造決定

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• ペルオキシソーム局在化シグナルPTS2とPex7,Pex21の三者複合体の結晶構造

  PAN DONGQING; NAKATSU TOORU; KATO HIROAKI

  日本生化学会大会(Web), 2012

  
• メタノール資化性酵母Pichia pastoris由来Pex3‐Pex19pの結晶構造

  HIRAI HIDENORI; FUKUSHIMA(EGAWA) KYOKO; NAKATSU TOORU; KATO HIROAKI

  日本生化学会大会(Web), 2012

  
• ホタル由来ルシフェラーゼのオキシルシフェリンアナログ複合体の高分解能X線結晶構造解析

  TERAKADO KANAKO; PANCHE NAUMOV; GOMI KEIKO; KAJIYAMA NAOKI; KATO HIROAKI; NAKATSU TOORU

  日本生化学会大会(Web), 2012

  
• 小胞体膜上に局在するABCD4(P70R)の存在様式と機能

  UESUGI TAISUKE; AKAIKE SOHO; KASHIWAYAMA YASUNORI; MORITA MASASHI; KATO HIROAKI; IMANAKA TSUNEO

  生体膜と薬物の相互作用シンポジウム講演要旨集, 24 Nov. 2011

  
• Coniochaeta sp.NISL9330由来Fructosyl peptide oxidaseのX線結晶構造解析

  ICHIYANAGI ATSUSHI; HIROKAWA KOZO; GOMI KEIKO; NAKATSU TOORU; KATO HIROAKI; KAJIYAMA NAOKI

  日本生物工学会大会講演要旨集, 25 Aug. 2011

  
• 2Dp09 Crystal structure of fructosyl peptide oxidase from Coniochaeta sp. NISL9330

  Ichiyanagi Atsushi; Hirokawa Kozo; Gomi Keiko; Nakatsu Toru; Kato Hiroaki; Kajiyama Naoki

  日本生物工学会大会講演要旨集, 25 Aug. 2011

  
• 好熱性紅藻由来の基質排出型ABCトランスポーターの基質特異性の解析

  YAMAGUCHI TOMOHIRO; SAKIYAMA KEITA; SATO TOMOMI; KODAN ATSUSHI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 27 May 2011

  
• メタノール資化性酵母Pichia pastoris由来Pex3‐Pex19pの結晶構造

  HIRAI HIDENORI; FUKUSHIMA(EGAWA) KYOKO; NAKATSU TOORU; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 27 May 2011

  
• 好熱性真核生物由来の多剤排出ABCトランスポーターの機能解析

  YAMAGUCHI TOMOHIRO; SAKIYAMA KEITA; JINUSHI RYOHEI; SATO YUMI; KODAN ATSUSHI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• K_ATPチャネル複合体の精製および単粒子構造解析

  KANNO RYO; KIMURA YASUHISA; MATSUO MICHINORI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• ゲンジボタルルシフェラーゼの発光色決定メカニズムの解明

  TERAKADO KANAKO; YOSHIMUNE RYOSUKE; GOMI KEIKO; KAJIYAMA NAOKI; IKEUCHI HIDEYUKI; HIRATAKE JUN; KATO HIROAKI; NAKATSU TOORU

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• 新規ABCトランスポーター阻害剤の開発研究

  IKEGUCHI KEIJI; SAKIYAMA KEITA; WATANABE BUNTA; YAMAGUCHI TOMOHIRO; NAKATSU TOORU; KATO HIROAKI; HIRATAKE JUN

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• ヒト培養細胞を用いた哺乳類膜タンパク質大量発現系の構築―K_ATPチャネル複合体の精製―

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; KIOKA NORIYUKI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本生体エネルギー研究会討論会講演要旨集, 2011

  
• ヒト培養細胞による哺乳類膜タンパク質の大量発現系構築

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; KIOKA NORIYUKI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 2011

  
• ライソゾーム病(ファブリ病含む)に関する調査研究 II.病態解析 ペルオキシソーム膜形成の分子機構とその障害による病態

  IMANAKA TSUNEO; KASHIWAYAMA YASUNORI; MORITA MASASHI; KATO HIROAKI

  ライソゾーム病(ファブリ病含む)に関する調査研究 平成22年度総括・分担研究年度終了報告書, 2011

  
• ゲンジボタルルシフェラーゼの発光色制御メカニズムの解明

  TERAKADO KANAKO; YOSHIMUNE YOSHIHIRO; GOMI KEIKO; KAJIYAMA NAOKI; IKEUCHI HIDEYUKI; HIRATAKE JUN; KATO HIROAKI; NAKATSU TOORU

  日本結晶学会年会講演要旨集, 2011

  
• ゲンジボタルルシフェラーゼの発光色制御メカニズムの解明

  TERAKADO KANAKO; YOSHIMUNE YOSHIHIRO; GOMI KEIKO; KAJIYAMA NAOKI; IKEUCHI HIDEYUKI; HIRATAKE JUN; KATO HIROAKI; NAKATSU TOORU

  日本結晶学会年会講演要旨集, 2011

  
• 好熱性紅藻由来ABCトランスポーターの多剤排出活性の特徴

  YAMAGUCHI TOMOHIRO; SAKIYAMA KEITA; IKEGUCHI KEIJI; JINUSHI RYOHEI; SATO YUMI; WATANABE BUNTA; KODAN ATSUSHI; NAKATSU TOORU; HIRATAKE JUN; UEDA KAZUMITSU; KATO HIROAKI

  生体膜と薬物の相互作用シンポジウム講演要旨集, 29 Nov. 2010

  
• ペルオキシソーム膜タンパク質の運搬受容体相互作用の構造生物学

  KATO HIROAKI

  生体膜と薬物の相互作用シンポジウム講演要旨集, Nov. 2010, Invited

  
• ジベレリン受容体による構造認識とその分子進化

  KATO HIROAKI

  日本農芸化学会関西支部講演会講演要旨集, 02 Oct. 2010

  
• 昆虫細胞を用いたジベレリンシグナル伝達に関わるタンパク質の発現精製系の構築

  SATO TOMOMI; NAOE YOICHI; SAKIYAMA KEITA; NAKATSU TOORU; KAMIGUCHI(TANAKA) MIYAKO; MATSUOKA MAKOTO; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 15 May 2010

  
• 構造解析品質の膜蛋白質調製のための大量培養系

  KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 15 May 2010

  
• Y257A変異導入によるゲンジボタルルシフェラーゼの発光メカニズムの解明

  TERAKADO KANAKO; YOSHIMUNE RYOSUKE; GOMI KEIKO; KAJIYAMA NAOKI; IKEUCHI HIDEYUKI; HIRATAKE JUN; KATO HIROAKI; NAKATSU TOORU

  日本蛋白質科学会年会プログラム・要旨集, 15 May 2010

  
• 好熱性紅藻Cyanidioschyzon merolae由来のABCトランスポーターの発現,精製,及び機能解析

  SAKIYAMA KEITA; YAMAGUCHI TOMOHIRO; KODAN ATSUSHI; NAKATSU TOORU; SATO YUMI; UEDA KAZUMITSU; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 15 May 2010

  
• ヒト培養細胞発現系を用いたKATPチャネル複合体の精製および機能評価

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• ホタルルシフェラーゼの発光色決定メカニズムの解明

  YOSHIMUNE YOSHIHIRO; TERAKADO KANAKO; KATO HIROAKI; NAKATSU TOORU

  日本結晶学会年会講演要旨集, 2010

  
• 構造解析を目指した高難度組換え蛋白質生産の最前線

  高木淳一; 加藤博章

  第10 回日本蛋白質科学会年会ワー クショップ（2010 年6 月18 日 北海道）, 2010, Peer-reviewed

  
• Functional role of the two intracellular helices, IH1 and IH2, in Escherichia coli ABC transporter MsbA

  JINUSHI Ryohei; YAMAGUCHI Tomohiro; SATO Tomomi; NAKATSU Toru; KATO Hiroaki

  第31回生体膜と薬物の相互作用シンポジウム講演要旨集, Nov. 2009

  
• Isolation and biochemical characterization of an ABC transporter from a thermophilic red alga, Cyanidioschyzon merolae

  YAMAGUCHI Tomohiro; SAKIYAMA Keita; KODAN Atsushi; NAKATSU Toru; UEDA Kazumitsu; KATO Hiroaki

  第31回生体膜と薬物の相互作用シンポジウム講演要旨集, Nov. 2009

  
• ヒト由来ペルオキシソーム膜タンパク質輸送因子Pex3PとPex19Pの構造基盤

  SATO YASUHIKO; SHIBATA HIROYUKI; NAKATSU TOORU; NAKANO HIROAKI; KASHIWAYAMA YASUNORI; IMANAKA TSUNEO; KATO HIROAKI

  生化学, 25 Sep. 2009

  
• C末端の二本のαヘリックスの欠失による大腸菌由来ABCトランスポーターMsbA結晶の改良

  TERAKADO KANAKO; KODAN ATSUSHI; NAKANO HIROAKI; KIMURA YASUHISA; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  生化学, 25 Sep. 2009

  
• ヒト培養細胞を用いたATP感受性カリウムチャネルの大量発現・精製手法の開発

  KIMURA YASUHISA; HIRAYAMA HIROSHI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 25 Sep. 2009

  
• メタノール資化性酵母Pichia pastorisを用いたABCタンパク質の大量生産

  KODAN ATSUSHI; SAKIYAMA KEITA; YAMAGUCHI TOMOHIRO; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  生化学, 25 Sep. 2009

  
• 植物の生長制御に関わるシグナル受容因子の構造と機能

  MATSUOKA MAKOTO; SHIMADA ASAKO; UEGUCHI(TANAKA) MIYAKO; NAKATSU TOORU; NAKAJIMA MASATOSHI; NAOE YOICHI; KATO HIROAKI

  生化学, 25 Sep. 2009

  
• メタノール資化性酵母Pichia pastoris由来Pex3‐Pex19p相互作用の解析

  HIRAI HIDENORI; EGAWA KYOKO; SHIBATA HIROYUKI; NAKATSU TOORU; KATO HIROAKI

  生化学, 25 Sep. 2009

  
• ターゲットタンパク研究プログラムの紹介 1.生産部門 真核生物由来膜蛋白質の結晶化支援法の開発 GFP融合技術を用いた結晶化能判定系と酵母による蛋白質生産系

  KATO HIROAKI; YAMASHITA ATSUKO; EGAWA KYOKO; SAKIYAMA KEITA

  蛋白質 核酸 酵素, 10 Sep. 2009

  
• ジベレリン受容体の立体構造に基づく分子進化と基質認識機構の解明

  SHIMADA ASAKO; KAMIGUCHI(TANAKA) MIYAKO; NAKATSU TOORU; NAKAJIMA MASATOSHI; NAOE YOICHI; OMIYA HIROKO; KATO HIROAKI; MATSUOKA MAKOTO

  日本蛋白質科学会年会プログラム・要旨集, 24 Apr. 2009

  
• ジベレリン受容体の立体構造を基にした分子進化と基質特異性の解析

  SHIMADA ASAKO; KAMIGUCHI(TANAKA) MIYAKO; NAKATSU TOORU; NAKAJIMA MASATOSHI; NAOE YOICHI; OMIYA HIROKO; KATO HIROAKI; MATSUOKA MAKOTO

  日本植物生理学会年会要旨集, 16 Mar. 2009

  
• ヒト培養細胞を用いたATP感受性カリウムチャネル複合体の大量生産,高純度精製

  KIMURA YASUHISA; HIRAYAMA YUJI; MATSUO MICHINORI; KIOKA NORIYUKI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• ルシフェリン再生酵素のX線結晶構造解析

  OKUDA TOMOHIKO; GOMI KEIKO; KAJIYAMA NAOKI; KATO HIROAKI; NAKATSU TOORU

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 多剤排出トランスポーターP糖タンパク質のリンカー領域の薬物輸送における役割

  SATO TOMOMI; KODAN ATSUSHI; KIMURA YASUHISA; UEDA KAZUMITSU; NAKATSU TOORU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• ヒト由来BMALI:CLOCKのbHLHドメインの精製および結晶化

  SAKAI ERIKO; TAKUMI TOORU; KATO HIROAKI; NAKATSU TOORU

  日本薬学会年会要旨集, 05 Mar. 2009

  
• Mechanism of efficient firefly bioluminescence via adiabatic transition state and seam of sloped conical intersection

  Lung Wa Chung; Shigehiko Hayashi; Toru Nakatsu; Hiroaki Kato; Keiji Morokuma

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  
• ヒト由来ペルオキシソーム膜タンパク質輸送に関与するPex3p‐Pex19p断片複合体のX線結晶構造解析

  SHIBATA HIROYUKI; SATO YASUHIKO; NAKATSU TOORU; NAKANO HIROAKI; KASHIWAYAMA YASUNORI; IMANAKA TSUNEO; KATO HIROAKI

  日本結晶学会年会講演要旨集, 2009

  
• 3S5-4 Development of innovative methods to support membrane protein crystallization(3S5 Development of Protein Production and Structural Analysis technologies in the Targeted Proteins Research Program,The 46th Annual Meeting of the Biophysical Society of

  Kato Hiroaki

  Biophysics, 25 Oct. 2008

  
• ヒト培養細胞を用いたヒトABCタンパク質大量発現・精製手法の構築

  KIMURA YASUHISA; HIRAYAMA YUJI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会関西支部講演会講演要旨集, 10 Sep. 2008

  
• ペルオキシソーム膜タンパク質輸送に関与するPex3pとPex19pの相互作用様式

  SATO YASUHIKO; SHIBATA HIROYUKI; NAKANO HIROAKI; MATSUZONO YUJI; KASHIYAMA YASUNORI; KOBAYASHI YUJI; FUJIKI YUKIO; IMANAKA TSUNEO; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 23 May 2008

  
• T‐20(Fuzeon)耐性HIV‐1変異株における6‐ヘリカルバンドル構造のX線構造解析

  WATABE TSUYOSHI; OISHI SHIN'YA; NISHIKAWA HIROKI; WATANABE KENTARO; NAKANO HIROAKI; NAKATSU TOORU; ONO HIROAKI; KATO HIROAKI; KODAMA EIICHI; MATSUOKA MASAO; FUJII NOBUTAKA

  日本化学会講演予稿集, 12 Mar. 2008

  
• 構造解析に適した真核生物由来のABCトランスポーターのスクリーニング

  SAKIYAMA KEITA; KIMURA YASUHISA; KODAN ATSUSHI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2008

  
• 結晶化に適した好熱菌由来ABCトランスポーターのスクリーニング

  SATO TOMOMI; NAKATSU TOORU; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2008

  
• ヒト培養細胞を用いたヒトABCトランスポーターの大量発現系の構築および精製条件スクリーニング手法の開発

  KIMURA YASUHISA; HIRAYAMA YUJI; ASAMI NARUMI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 2008

  
• BIOFLO310を用いた大腸菌高密度培養による膜タンパク質の効率的生産系

  KODAN ATSUSHI; TERAKADO KANAKO; SUEGAMI SHINJI; KUBO TAKESHI; UEDA KAZUMITSU; NISHIKAWA SHIGEMICHI; KATO HIROAKI

  生化学, 2008

  
• S14I2 Luciferin-Luciferase interaction and Control of firefly's luminescent color(Protein-Ligand Interactions)

  Kato Hiroaki

  Biophysics, 20 Nov. 2007

  
• 多剤排出トランスポーターP糖タンパク質におけるリンカー領域の役割

  SATO TOMOMI; KODAN ATSUSHI; KIMURA YASUHISA; NAKATSU TOORU; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 07 May 2007

  
• 結晶化を目指したペルオキシソーム膜タンパク質22のメタノール資化性酵母Pichia pastorisによる大量生産

  EGAWA KYOKO; SHIBATA HIROYUKI; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 07 May 2007

  
• 酵素の立体構造から見たモノグルコシダーゼからジグリコシダーゼへの分子進化

  SAINO HIROMICHI; MIZUTANI SHOJI; HIRATAKE JUN; SHIMIZU TETSUYA; KATO HIROAKI; SAKATA KANZO

  日本植物生理学会年会要旨集, 15 Mar. 2007

  
• メタノール資化性酵母Pichia pastorisを用いたラットペルオキシソーム膜タンパク質22の発現系の構築

  EGAWA KYOKO; SHIBATA HIROYUKI; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2007

  
• チャ樹由来β‐プリメペロシダーゼの二糖認識機構の解明

  SAINO HIROMICHI; MIZUTANI MASAHARU; HIRATAKE JUN; SHIMIZU TETSUYA; KATO HIROAKI; SAKATA KANZO

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• ホタルの発光は、どうして黄緑色なのか?

  加藤 博章; 中津 亨

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Mar. 2007

  
• Structural basis for evolution of diglycosidases from monoglucosidases in plants

  Hiromichi Saino; Masaharu Mizutani; Jun Hiratake; Tetzuya Shimizu; Hiroaki Kato; Kanzo Sakata

  PLANT AND CELL PHYSIOLOGY, 2007

  
• 難分解性プロリルペプチドを開裂する好熱性Aneurinibacillus属細菌AM‐1株由来アミノペプチダーゼのX線結晶構造解析

  AKIOKA MAKOTO; NAKANO HIROAKI; TSUJIMOTO YOSHIYUKI; MATSUI HIROSHI; KATO HIROAKI; WATANABE KUNIHIKO

  日本農芸化学会関西支部講演会講演要旨集, 2007

  
• X線結晶構造解析によるリンゴ銀葉病菌由来エンドポリガラクツロナーゼIの基質認識機構解明

  SHIMIZU TETSUYA; NAKATSU TOORU; SHIMIZU NOBUTAKA; MIYAIRI KAZUO; OKUNO TOMOAKI; YAMAMOTO MASAKI; KATO HIROAKI

  日本結晶学会年会講演要旨集, 2007

  
• 好熱菌Geobacillus collagenovorans MO‐1株由来Pz‐ペプチダーゼAのX線結晶構造解析―阻害剤結合モデルに基づくコラーゲン特異的繰り返し配列認識機構の解明―

  KAWASAKI AKIO; NAKANO HIROAKI; TSUJIMOTO YOSHIYUKI; MATSUI HIROSHI; KATO HIROAKI; WATANABE KUNIHIKO

  日本農芸化学会関西支部講演会講演要旨集, 2007

  
• ホタル発光色制御メカニズムの立体構造基盤

  KATO HIROAKI

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 19 Sep. 2006

  
• ペルオキシソーム膜タンパク質輸送に関与するPex3pの単離精製及びPex19pとの結合様式の解析

  SATO YASUHIKO; SHIBATA HIROYUKI; NAKANO HIROAKI; IMANAKA TSUNEO; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 31 Mar. 2006

  
• Stereum purpureum由来エンドポリガラクツロナーゼの超高分解能(0.62Å)X線結晶構造解析

  SHIMIZU TETSUYA; NAKATSU TOORU; SHIMIZU NOBUTAKA; SHIBATA HIROYUKI; MIYAIRI KAZUO; OKUNO TOSHIKATSU; YAMAMOTO MASAKI; KATO HIROAKI

  日本蛋白質科学会年会プログラム・要旨集, 31 Mar. 2006

  
• 好熱性Aneurinibacillus属細菌AM‐1株が生産するアミノペプチダーゼの結晶化とX線構造解析

  AKIOKA MAKOTO; NAKANO HIROAKI; KATO HIROAKI; TSUJIMOTO YOSHIYUKI; MATSUI HIROSHI; WATABE KUNIHIKO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• Stereum purpureum由来エンドポリガラクツロナーゼIにおけるAsn92結合糖鎖の熱安定性への関与

  SHINTANI TOMOYUKI; SHIMIZU TETSUYA; NAKATSU TOORU; KATO HIROAKI; YOSHIDA TAKASHI; OKUNO TOMOAKI; MIYAIRI KAZUO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• 植物由来ジグリコシダーゼのX線結晶構造解析

  SAINO HIROMICHI; MIZUTANI MASAHARU; HIRATAKE JUN; SHIMIZU TETSUYA; KATO HIROAKI; SAKATA KANZO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• コラーゲン分解性好熱性細菌Geobacillus collagenovorans MO‐1株が生産するPz‐ペプチダーゼA,Bの速度パラメータ決定と結晶化

  KAWASAKI AKIO; SUGIHARA YUSUKE; NAKANO HIROAKI; KATO HIROAKI; TSUJIMOTO YOSHIYUKI; MATSUI HIROSHI; WATABE KUNIHIKO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• コラーゲン分解性好熱菌 Geobacillus collagenovorans MO‐1株が生産する2つのPz‐ペプチダーゼに関する研究―速度パラメータ,阻害剤,結晶化の検討

  KAWASAKI AKIO; NAKANO HIROAKI; KATO HIROAKI; TSUJIMOTO YOSHIYUKI; MATSUI YUTAKA; WATANABE KUNIHIKO

  日本農芸化学会関西支部講演会講演要旨集, 2006

  
• エンドポリガラクツロナーゼ反応機構解明を目指した硫黄置換オリゴガラクツロン酸の設計と合成

  YAMAMOTO KAZUNORI; WATANABE NAOKI; ARAYA TOMOYUKI; HASHIMOTO MASARU; MIYAIRI KAZUO; OKUNO TOSHIKATSU; OKAZAKI ISAO; SAITO MINORU; SHIMIZU TETSUYA; KATO HIROAKI

  天然有機化合物討論会講演要旨集, 15 Sep. 2005

  
• P-3 Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid

  Yamamoto Kazunori; Watanabe Naoki; Araya Tomoyuki; Hashimoto Masaru; Miyairi Kazuo; Okuno Toshikatsu; Okazaki Isao; Saito Minoru; Shimizu Tetsuya; Kato Hiroaki

  天然有機化合物討論会講演要旨集, 15 Sep. 2005

  
• Stereum purpureum由来エンドポリガラクツロナーゼIの熱安定性に対するAsn92に結合したGlcNAcの重要性

  SHINTANI TOMOYUKI; SHIMIZU TETSUYA; NAKATSU TOORU; KATO HIROAKI; YOSHIDA TAKASHI; OKUNO TOMOAKI; MIYAIRI KAZUO

  J Appl Glycosci, 20 Jul. 2005

  
• Fructosyl‐amino acid oxidase from Corynebacterium sp.2‐4‐1のX線結晶構造解析

  YAMAGUCHI YOKO; NAKATSU TOORU; SHIMIZU TETSUYA; SAKAGAMI RYOICHI; KAJIYAMA NAOKI; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• ペルオキシソーム膜タンパク質輸送に関与するPex19p,Pex3pの単離精製及び機能解析

  SATO YASUHIKO; SHIBATA HIROYUKI; NAKANO HIROAKI; IMANAKA TSUNEO; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• stereum purpureum由来エンドポリガラクツロナーゼI遺伝子の発現とその組み換え酵素の性質

  SHINTANI TOMOYUKI; YAMADA YUKI; MIYAIRI KAZUO; OKUNO TOMOAKI; SHIMIZU TETSUYA; SHIBATA HIROYUKI; KATO HIROAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• 創薬資源としての天然物研究の新展開をめざして 生物時計タンパク質の立体構造と機能

  KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• 抗SARS‐CoVペプチドの創製と阻害様式についての考察

  NISHIKAWA YUKI; OTAKA AKIRA; SASAKI YOSHIKAZU; KATO TERUKAZU; NAKANO HIROAKI; YAMAMOTO NORIO; TAMAMURA HIROKAZU; KATO HIROAKI; YAMAMOTO NAOKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• 昆虫細胞Sf+を用いたヒトP糖タンパク質の大量精製

  TERAKADO KANAKO; KODAN ATSUSHI; SATO TOMOMI; SHIBATA HIROYUKI; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• β‐プリメベロシルアミジン誘導体をリガンドにしたアフィニティーカラムによるβ‐プリメベロシダーゼの精製と結晶化

  SAINO HIROMICHI; MIZUTANI MASAHARU; HIRATAKE JUN; SHIMIZU TETSUYA; KATO HIROAKI; SAKATA KANZO

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• 高等植物由来の光化学系II PsbPタンパク質の構造機能相関

  SHIMAMOTO TADASHI; IFUKU KENTARO; NAKATSU TOORU; KATO HIROAKI; SATO FUMIHIKO

  日本植物生理学会年会要旨集, Mar. 2005

  
• Structure-function relationship of PsbP protein of photosystem II from higher plants

  R Simamoto; K Ifuku; T Nakatsu; H Kato; F Sato

  PLANT AND CELL PHYSIOLOGY, 2005

  
• Smaller and finer-ultra high resolution analysis and microcrystal analysis.

  KATO HIROAKI

  構造生物学(10)講演要旨集 これからの構造生物学における新ツール 理研シンポジウム 平成17年, 2005

  
• Studies on the reaction mechanism of enzymes by kinetic crystallography

  KATO HIROAKI

  スーパーコンピューターラボラトリー 平成16年度 研究成果報告書, 2005

  
• 原子分解能X線結晶構造解析と中性子線結晶構造解析による水素原子の可視化

  KATO HIROAKI

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2004

  
• 抗SARS活性ペプチドの創製研究

  NISHIKAWA HIROKI; OTAKA AKIRA; SASAKI YOSHIKAZU; KATO TERUKAZU; NAKANO HIROAKI; YAMAMOTO NORIO; TAMAMURA HIROKAZU; KATO HIROAKI; YAMAMOTO NAOKI

  メディシナルケミストリーシンポジウム・日本薬学会医薬化学部会年会講演要旨集, 24 Nov. 2004

  
• ペルオキシソーム膜形成因子Pex19pのNMR解析

  SASAKAWA HIROAKI; YAMAGUCHI YOSHIKI; SHIBATA HIROYUKI; KATO HIROAKI; KATO KOICHI

  NMR討論会講演要旨集, 10 Nov. 2004

  
• 3SB02 Enzyme reaction mechanism analyzed by atomic resolution crystallography

  Kato H

  Biophysics, 10 Nov. 2004

  
• 1P025 Role of KaiA functional domains in circadian rhythms of cyanobacteria as revealed by crystal structure

  Uzumaki T; Fujita M; Nakatsu T; Hayashi F; Shibata H; Itoh N; Kato H; Ishiura M

  Biophysics, 10 Nov. 2004

  
• ペルオキシソーム膜ABCタンパク質PMP70の局在化機構―シャペロン様タンパク質Pex19pの役割―

  KASHIWAYAMA YOSHINORI; ASAHINA KOTATA; SHIBATA HIROYUKI; KATO HIROAKI; MORITA MASASHI; IMANAKA TSUNEO

  生体膜と薬物の相互作用シンポジウム講演要旨集, 01 Nov. 2004

  
• 藍色細菌の時計タンパク質KaiAの構造と機能 機能ドメイン,X線結晶構造解析及び構造―機能相関の解明

  UZUMAKI TATSUYA; NAKATSU TOORU; KATO HIROAKI; ISHIURA MASAHIRO

  SPring-8利用者情報, 30 Sep. 2004

  
• Dynamic light scattering

  KATO HIROAKI

  蛋白質 核酸 酵素, 10 Aug. 2004

  
• 反応を制御する表在性蛋白質:配置と機能―X線構造解析が示す構造―

  IFUKU KENTARO; NAKATSU TOORU; KATO HIROAKI; SATO FUMIHIKO

  日本植物生理学会年会要旨集, 20 Mar. 2004

  
• γ‐グルタミルシステイン合成酵素遷移状態アナログ複合体のX線結晶構造解析

  HIBI TAKAO; NII HIROSHI; NAKATSU TOORU; HIRATAKE JUN; KATO HIROAKI; ODA JUN'ICHI

  日本農芸化学会大会講演要旨集, 05 Mar. 2004

  
• Extrinsic proteins regulating oxygen-evolving reaction: Arrangement and function - X-ray crystallographic structure analysis

  K Ifuku; T Nakatsu; H Kato; F Sato

  PLANT AND CELL PHYSIOLOGY, 2004

  
• Key chemical substances in unsolved biological phenomena. X-ray crystal structure analysis of intermediate analog complex of Luciola cruciata luciferase reaction.

  KATO HIROAKI; NAKATSU TOORU

  未解明生物現象を司る鍵化学物質 平成11-14年度 No.11175101, 2004

  
• リンゴ銀葉病菌が産生するエンドポリガラクツロナーゼIの中性子結晶構造解析と機能解析

  SATO MAMORU; SHIMIZU TETSUYA; NAKATSU TOORU; KURIHARA KAZUO; NIIMURA NOBUO; MIYAIRI KAZUO; OKUNO TOMOAKI; KATO HIROAKI

  日本中性子科学会年会講演概要集, 2004

  
• タンパク質の構造解析と医薬品開発への応用

  KATO HIROAKI

  関西界面科学セミナー講演要旨集, 31 Jul. 2003

  
• トウモロコシピルビン酸リン酸ジキナーゼのX線結晶構造解析 2

  NAKANISHI AMI; NAKATSU TOORU; MATSUOKA MAKOTO; SAKATA KANZO; KATO HIROAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• ペルオキシソーム膜タンパク質局在化機構の解析―Pex19pの機能性部位の探索

  SHIBATA HIROYUKI; KASHIYAMA YOSHINORI; MORITA MASASHI; IMANAKA TSUNEO; KATO HIROAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• ゲンジボタル由来ルシフェラーゼの発光色決定機構

  KOBASHI NOBUYUKI; NAKAZU TOORU; ICHIYAMA SUSUMU; HIRATAKE JUN; KATO HIROAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• γ‐グルタミルシステイン合成酵素遷移状態アナログ複合体の結晶化と構造解析

  NII HIROSHI; HIBI TAKAO; HIRATAKE JUN; NAKATSU TOORU; KATO HIROAKI; ODA JUN'ICHI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• PMP70のペルオキシソーム膜局在化機構におけるPex19pの役割

  KASHIYAMA YASUNORI; MORITA MASASHI; SHIBATA HIROYUKI; KATO HIROAKI; IMANAKA TSUNEO

  日本薬学会年会要旨集, 05 Mar. 2003

  
• 大腸菌B株由来γ‐グルタミルシステイン合成酵素のX線結晶構造解析

  HIBI TAKAO; NAKATSU TOORU; KATO HIROAKI; ODA JUN'ICHI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• Crystal structure of the extrinsic 23-kDa protein in the oxygen-evolving complex of photosystem II

  K Ifuku; T Nakatsu; H Kato; F Sato

  PLANT AND CELL PHYSIOLOGY, 2003

  
• ペルオキシソーム膜ABCタンパク質PMP70の局在化におけるPex19pの役割

  KASHIWAYAMA YASUNORI; ASAHINA KOTA; SHIBATA HIROYUKI; KATO HIROAKI; MORITA MASASHI; IMANAKA TSUNEO

  生体膜と薬物の相互作用シンポジウム講演要旨集, 07 Nov. 2002

  
• Role of Pex19p in the targeting of PMP70 to peroxisome

  Y Kashiwayama; M Morita; H Shibata; H Kato; T Imanaka

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2002

  
• X線結晶構造解析によるホタルルシフェラーゼの発光反応機構および発光色決定機構の解明

  NAKATSU TOORU; ICHIYAMA SUSUMU; ADRIAN S; HIRATAKE JUN; SAKATA KANZO; KATO HIROAKI

  生化学, 25 Aug. 2002

  
• PMP70のペルオキシソーム局在化におけるPex19pの役割

  KASHIWAYAMA YOSHINORI; MORITA MASASHI; SHIBATA HIROYUKI; KATO HIROAKI; IMANAKA TSUNEO

  生化学, 25 Aug. 2002

  
• エンドポリガラクツロナーゼ/ガラクツロン酸複合体の超高分解能X線結晶構造解析

  SHIMIZU TETSUYA; NAKATSU TOORU; MIYAIRI KAZUO; OKUNO TOMOAKI; KATO HIROAKI

  生化学, 25 Aug. 2002

  
• 超高分解能X線結晶構造解析に基づくエンドポリガラクツロナーゼの作用機構

  SHIMIZU TETSUYA; NAKATSU TOORU; MIYAIRI KAZUO; OKUNO TOSHIKATSU; KATO HIROAKI

  日本糖質学会年会要旨集, 25 Jul. 2002

  
• γ-グルタミルシステイン合成酵素遷移状態アナログ複合体の結晶化

  仁位 寛; 日び隆雄; 平竹 潤; 中津 亨; 加藤博章; 小田順一

  第２回日本蛋白質科学会年会 ,名古屋, 14 Jun. 2002

  
• リボソーム再生因子(RRF)の立体構造解析と活性発現機構

  NAKANO HIROAKI; UCHIYAMA SUSUMU; YOSHIDA TAKUYA; KATO HIROAKI; OKUBO TADAYASU; YAMAGATA YURIKO; KOBAYASHI YUJI

  日本薬学会年会要旨集, 05 Mar. 2002

  
• トウモロコシ由来ピルビン酸リン酸ジキナーゼのX線結晶構造解析

  NAKANISHI AMI; NAKATSU TOORU; MATSUOKA MAKOTO; SAKATA KANZO; KATO HIROAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 光化学系2酸素発生系23‐kDaタンパク質に関する生化学的解析と結晶化

  IFUKU KENTARO; NAKATSU TOORU; YAMAMOTO YUMIKO; KATO HIROAKI; SATO FUMIHIKO

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• PSD‐Zip45におけるHomer1ファミリー保存領域のX線結晶構造解析

  IRIE KATSUMASA; NAKATSU TOORU; MITSUOKA KAORU; MIYAZAWA ATSUO; SOBUE KENJI; HIROAKI YOKO; DOI TOMOKO; FUJIYOSHI YOSHINORI; KATO HIROAKI

  日本生物物理学会年会講演予稿集, Oct. 2001

  
• Crystal structure of PSD-Zip45 conserved region of the Homer 1 family

  Irie K; Nakatsu T; Mitsuoka K; Miyazawa A; Sobue K; Hiroaki Y; Doi T; Fujiyoshi Y; Kato H

  Biophysics, 10 Sep. 2001

  
• 酵素反応をX線結晶構造解析で捉えるには

  KATO HIROAKI

  生化学, 25 Aug. 2001

  
• 蛋白質間相互作用における脂質修飾の役割 カルモジュリン‐ミリスチル化蛋白質複合体の結晶構造解析と相互作用解析

  MATSUBARA MAMORU; NAKATSU TOORU; YAMAUCHI EMIKO; KATO HIROAKI; TANIGUCHI TOSHIAKI

  生化学, 25 Aug. 2001

  
• カルモジュリン‐MARCKSペプチド複合体の結晶構造解析

  YAMAUCHI EMIKO; NAKATSU TOORU; MATSUBARA MAMORU; KATO HIROAKI; TANIGUCHI TOSHIAKI

  生化学, 25 Aug. 2001

  
• Time-resolved X-ray crystallography by Laue diffraction.

  KATO HIROAKI

  蛋白質 核酸 酵素, 10 Aug. 2001

  
• ラウエ法を用いた時分割X線結晶構造解析 (新世紀における蛋白質科学の進展) -- (第1部 蛋白質研究方法の進展)

  加藤 博章

  蛋白質核酸酵素, Aug. 2001

  
• 光化学系2酸素発生系23kDaタンパク質のN末端アミノ酸配列とイオン保持能

  IFUKU KENTARO; NAKATSU TOORU; KATO HIROAKI; SATO FUMIHIKO

  日本植物生理学会年会要旨集, 21 Mar. 2001

  
• トウモロコシ由来ピルビン酸リン酸ジキナーゼの結晶学的研究

  NAKANISHI TSUGIZANE; NAKATSU TOORU; MATSUMOTO TAKASHI; SAKATA KANZO; MATSUOKA MAKOTO; KATO HIROAKI

  日本農芸化学会誌, 05 Mar. 2001

  
• ヒトMDR1の昆虫細胞での大量発現,精製及びATP加水分解活性の測定

  KIMURA YASUHISA; MORINAGA MANABU; MATSUO MICHINORI; MATSUMOTO TAKASHI; KATO HIROAKI; KIOKA NORIYUKI; AMACHI TERUO; UEDA KAZUMITSU

  日本農芸化学会誌, 05 Mar. 2001

  
• リンゴ銀葉病菌の生産するエンドポリガラクツロナーゼIのX線結晶構造解析 (第二報)

  SHIMIZU TETSUYA; NAKATSU TOORU; YAMAMOTO MASAKI; KUMASAKA TAKASHI; MIYAIRI KAZUO; OKUNO TOMONOBU; KATO HIROAKI

  日本農芸化学会誌, 05 Mar. 2001

  
• Stractural Biology Topics 速度論的結晶学 酵素の触媒作用にともなう構造変化の解析

  KATO HIROAKI

  構造生物学, 2001

  
• 2000年の化学 アミラーゼの反応中間体がX線結晶解析で捕らえられた!

  KATO HIROAKI

  化学, 01 Mar. 2000

  
• ATP依存性酵素の動力学的X線結晶構造解析

  KATO HIROAKI

  生理学研究所年報, 01 Dec. 1999

  
• Vibrio pahahaemolyticus由来ribosome recycling factor(RRF)遺伝子のクローニングとRRFの結晶化

  NAKANO HIROAKI; YAMAICHI YOSHIHARU; KASHIMORI HIROMASA; UCHIYAMA SUSUMU; YAMAGATA YURIKO; KATO HIROAKI; HONDA TAKESHI; KOBAYASHI YUJI

  日本分子生物学会年会プログラム・講演要旨集, 22 Nov. 1999

  
• A Mechanistic Probe for Enzyme Catalysis: Intermediate and Transition-State Analogues of g-Gutamylcysteine Synthetase

  J. Hiratake; M. Inoue; H. Kato

  Biotrans ’99, the 4th European Conference on Biocatalysis and Biotransformation ,Italy, 28 Sep. 1999

  
• アスパラギン合成酵素の還移状態アナログと構造解析への応用

  HIRATAKE JUN; NAKATSU TOORU; KATO HIROAKI

  生体触媒化学シンポジウム講演要旨集, 21 Jan. 1999

  
• Structural biology and the new drug discovery. Four-dimensional structure analysis of the enzyme.

  KATO HIROAKI

  ファルマシア, Jan. 1999

  
• 酵素の四次元構造解析

  加藤 博章

  ファルマシア, 1999

  
• ゲンジボタルルシフェラーゼ MgATP複合体の結晶構造

  NAKATSU TOORU; HIROKAWA KOZO; KAJIYAMA NAOKI; NAKANO EIICHI; KATO HIROAKI

  日本結晶学会年会講演要旨集, Nov. 1998

  
• 酵素反応に伴う四次元構造の解析

  KATO HIROAKI

  日本生物物理学会年会講演予稿集, 07 Sep. 1998

  
• トロピノン還元酵素のX線結晶構造解析 立体特異的反応を行うための構造要因の解明

  YAMASHITA ATSUKO; NAKAJIMA KEIJI; KATO HIROAKI; AKAMA HIROYUKI; NAKATSU TOORU; WAKATSUKI SOICHI; TOMIZAKI TAKASHI; HASHIMOTO TAKASHI; ODA JUN'ICHI

  タンパク質構造討論会講演要旨集, Sep. 1998

  
• 大腸菌由来アスパラギン合成酵素のＸ線結晶構造解析（その３） 酵素：遷移状態アナログ複合体結晶の構造解析

  中津 亨; 小泉三輝; 平竹 潤; 加藤博章; 小田順一

  日本農芸化学会１９９８年度大会 ,名古屋, 01 Apr. 1998

  
• X-ray Crystallographic Analyses of Two Reductases Catalyzing Opposite Stereospecific Reactions.

  NAKAJIMA KEIJI; YAMASHITA ATSUKO; AKAMA HIROYUKI; KATO HIROAKI; HASHIMOTO TAKASHI; ODA JUN'ICHI; YAMADA YASUYUKI

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1997

  
• X-ray Crystallographic Analyses of Two Reductases Catalyzing Opposite Stereospecific Reactions.

  NAKAJIMA KEIJI; YAMASHITA ATSUKO; AKAMA HIROYUKI; KATO HIROAKI; HASHIMOTO TAKASHI; ODA JUN'ICHI; YAMADA YASUYUKI

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1997

  
• Four-dimensional structure of enzyme: Watching enzyme at work by time-resolved X-ray crystallography.

  KATO HIROAKI; ODA JUN'ICHI

  バイオサイエンスとインダストリー, Jul. 1997

  
• γ-グルタミルシステイン合成酵素の遷移状態アナログ阻害剤（２）：側鎖置換 sulfoximine 誘導体の合成と阻害活性

  入江隆行; 徳竹伸哉; 平竹 潤; 加藤 真; 加藤博章; 小田順一

  日本農芸化学会１９９７年度大会 ,東京, 02 Apr. 1997

  
• アスパラギン合成酵素の遷移状態アナログ阻害剤の合成

  小泉三輝; 平竹 潤; 田ノ上信太郎; 中津 亨; 加藤博章; 小田順一

  日本農芸化学会１９９７年度大会 ,東京, 02 Apr. 1997

  
• Synthesis and Characterization of Specific Inhibitors of .GAMMA.-Glutamylcysteine Synthetase.

  HIRATAKE JUN; TOKUTAKE NOBUYA; IRIE TAKAYUKI; KATO MAKOTO; KATO HIROAKI; ODA JUN'ICHI

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, Dec. 1996

  
• DSC Study on the Thermal Unfolding of Glutathione Synthetase from Escherichia coli B.

  FUKADA HARUMI; TAKAHASHI KATSUTADA; KATO HIROAKI; ODA JUN'ICHI

  熱測定, Oct. 1996

  
• Change of cysteine residue of .GAMMA.-glutamylcysteine synthetase for the purpose of crystallization.

  HISADA HIROMOTO; KATO HIROAKI; KIMURA HIKARU; ODA JUN'ICHI

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1996

  
• Irreversible interference of .GAMMA.-glutamylcysteine synthetase by glutamic acid and .GAMMA. - hydroxamic acid.

  KATO MAKOTO; HIRATAKE JUN; KATO HIROAKI; ODA JUN'ICHI

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1996

  
• Transition-state analogue inhibitor of .GAMMA.-glutamylcysteine synthetase. Stereoselective synthesis and inhibitory activity.

  TOKUTAKE NOBUYA; IRIE TAKAYUKI; HIRATAKE JUN; KATO MAKOTO; KATO HIROAKI; ODA JUN'ICHI; OKAME YUMIKO; KOMAI KOICHIRO

  生体機能関連化学シンポジウム講演要旨集, Sep. 1996

  
• Dynamic crystal protein analysis by time sharing Laue method. 3. Application of Laue method to transition-state analog phosphorylation of glutathione synthetase. ( Ministry of Education S )

  KATO HIROAKI; AOYAGI SHU; HIRATAKE JUN; ODA JUN'ICHI

  News Letter 放射光による蛋白質結晶構造のミリ秒オーダーのダイナミックスの研究, Sep. 1996

  
• Substrate Recognition and Reaction Mechanism on Asparagine Synthetase from E. coli K-12.

  NAKATSU TOORU; KATO HIROAKI; ODA JUN'ICHI

  タンパク質構造討論会講演要旨集, Aug. 1996

  
• タバコオスモチン様タンパク質の立体構造

  小岩 尚志; 加藤 博章; 中津 亨; 小田 順一; 山田 康之; 佐藤 文彦

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Space structure of tobacco osmotin-like protein.

  KOIWA HISASHI; KATO HIROAKI; NAKATSU TOORU; ODA JUN'ICHI; YAMADA YASUYUKI; SATO FUMIHIKO

  日本分子生物学会年会プログラム・講演要旨集, Jul. 1996

  
• Control of enzyme reaction in crystal by flash photolysis using xenon lamp. (Ministry of Education S ).

  KATO HIROAKI; AOYAGI SHU; ODA JUN'ICHI

  News Letter 放射光による蛋白質結晶構造のミリ秒オーダーのダイナミックスの研究, Jun. 1996

  
• 大腸菌由来アスパラギン合成酵素のX線結晶構造解析(その2) : タンパク質工学

  中津 亨; 加藤 博章; 小田 順一

  日本農藝化學會誌, 05 Mar. 1996

  
• グルタチオン合成酵素の時間分割X線結晶解析 : ATPによるリン酸化反応の追跡(第1報) : タンパク質工学

  青柳 周; 加藤 博章; 平竹 潤; 小田 順一

  日本農藝化學會誌, 05 Mar. 1996

  
• Crystallization of antibacterial tobacco osmotine like protein (OLP).

  KOIWA HISASHI; KATO HIROAKI; NAKATSU TOORU; NISHIOKA TAKAAKI; ODA JUN'ICHI; YAMADA YASUYUKI; SATO FUMIHIKO

  日本植物生理学会年会要旨集, Mar. 1996

  
• Molecular structure of glutathione synthetase in transition state. Enzyme : X-ray crystal structure analysis of transition-state analogue complex.

  KATO HIROAKI; HIRATAKE JUN; ODA JUN'ICHI

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1995

  
• 大腸菌由来アスパラギン合成酵素の結晶解析 : タンパク質工学

  中津 亨; 加藤 博章; 小田 順一

  日本農藝化學會誌, 05 Jul. 1995

  
• リパーゼ活性化タンパク質LipB-アミノ末端欠損型変異体によるリパーゼの活性化 : 生体高分子・脂質

  柴田 洋之; 加藤 博章; 西岡 孝明; 小田 順一

  日本農藝化學會誌, 05 Jul. 1995

  
• γ-グルタミルシステイン合成酵素の遷移状態アナログ阻害剤(1) : 反応機構に基づいた阻害剤の設計と合成 : 有機化学・天然物化学

  平竹 潤; 加藤 真; 加藤 博章; 小田 順一

  日本農藝化學會誌, 05 Jul. 1995

  
• γ-グルタミルシステイン合成酵素の遷移状態アナログ阻害剤(2) : 阻害の活性および様式 : 有機化学・天然物化学

  加藤 真; 加藤 博章; 平行 潤; 田中 琢治; 小田 順一

  日本農藝化學會誌, 05 Jul. 1995

  
• Catalytic action and molecular movement :An approach from X-ray crystalline structural analysis.

  KATO HIROAKI

  日本農芸化学会関西支部講演会講演要旨集, Jul. 1995

  
• Substrate recognition mechanism of glutathione synthetase derived from Escherichia coli. (Ministry of Education S).

  YAMAGUCHI HIROSHI; KATO HIROAKI; TANAKA TAKUJI; NISHIOKA TAKAAKI; ODA JUN'ICHI; KATSUBE YUKITERU

  News Letter 放射光による蛋白質結晶構造のミリ秒オーダーのダイナミックスの研究, Feb. 1995

  
• CRYSTALLOGRAPHIC STUDIES OF GLUTATHIONE SYNTHETASE

  H KATO

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, Dec. 1994

  
• 大腸菌由来グルタチオン合成酵素の結晶構造解析とATP関連酵素の配列,立体構造との比較

  松田敬子; 水口賢司; 加藤博章; 西岡孝明; 郷信広; 小田順一

  情報化学討論会・構造活性相関シンポジウム講演要旨集, Nov. 1994

  
• Substrate recognition of glutathione synthetase from Escherichia coli B.

  YAMAGUCHI HIROSHI; KATO HIROAKI; TANAKA TAKUJI; NISHIOKA TAKAAKI; ODA JUN'ICHI; KATSUBE YUKITERU

  日本化学会講演予稿集, Sep. 1994

  
• Structural Biology of Glutathione Synthetase from Escherichia coli B.

  HARA TAKANE; KATO HIROAKI; NISHIOKA TAKAAKI; KATSUBE YUKITERU; ODA JUN'ICHI

  タンパク質構造討論会講演要旨集, Aug. 1994

  
• Visualization of Mobile Regions in Proteins by X-Ray Crystallography.

  KATO HIROAKI; ODA JUN'ICHI

  化学と生物, Jul. 1994

  
• X-ray crystalline structural analysis of glutathione synthetase.

  KATO HIROAKI

  日本農芸化学会関西支部講演会講演要旨集, May 1994

  
• グルタチオン合成酵素―基質複合体結晶の構造解析

  山口宏; 加藤博章; 小田順一; 勝部幸輝

  日本放射光学会年会予稿集, May 1994

  
• Pseudomonas属由来のリパーゼ活性化因子LipBの発現,精製及びその性質

  柴田洋之; 吉川和宏; 加藤博章; 西岡孝明; 小田順一

  日本農芸化学会誌, Mar. 1994

  
• グルタチオン合成酵素の遷移状態アナログの合成とその阻害活性 mechanism‐based enzyme inactivation

  平竹潤; 加藤博章; 小田順一

  日本農芸化学会誌, Mar. 1994

  
• 酵素反応過程の映像化 時分割X線結晶構造解析の現状,課題,展望

  加藤博章; 西岡孝明; 小田順一

  日本農芸化学会誌, Mar. 1994

  
• グルタチオン合成酵素のX線結晶構造解析

  加藤博章

  日本農芸化学会誌, Mar. 1994

  
• グルタチオン合成酵素・ADP・グルタチオン複合体のX線結晶構造解析

  原高峰; 加藤博章; 西岡孝明; 小田順一

  日本農芸化学会誌, Mar. 1994

  
• Use of Adenosine(5')polyphospho(5')pyridoxals To Study the Subustrate-Binding Region of Glutathione Synthetase from Escherichia coli B.

  Biochemistry, 1994

  
• The visualization of enzyme reaction on atomic level.

  KATO HIROAKI; ODA JUN'ICHI

  化学, Jan. 1994

  
• グルタチオン合成酵素におけるflexible loopの機能解析 (その5)

  田中琢治; 加藤博章; 西岡孝明; 小田順一

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1993

  
• グルタチオン合成酵素におけるATPのリン酸基およびMg結合部位周辺残基の機能解析

  沢田仁; 田中琢治; 加藤博章; 西岡孝明; 小田順一

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1993

  
• アデノシンテトラホスホピリドキサールによるグルタチオン合成酵素の親和標識,及びその還元固定化複合体のX線結晶構造解析

  日び隆雄; 谷沢克行; 山口宏; 加藤博章; 西岡孝明; 福井俊郎; 勝部幸輝; 小田順一

  タンパク質構造討論会講演要旨集, Sep. 1992

  
• RECENT PROGRESS IN THE STRUCTURE OF CN-BOND LIGASES

  H KATO; J ODA

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, Dec. 1991

  
• グルタチオン合成酵素の構造と機能―ループ欠損型酵素の構造解析―

  加藤 博章; 山口 宏; 田中 琢治; 原 高峰; 西岡 孝明; 木村 光; 勝部 幸輝; 小田 順一

  日本結晶学会誌, 1991

  
• グルタチオン合成酵素のX線結晶構造解析 (II)

  山口 宏; 加藤 博章; 畑 安雄; 松浦 良樹; 西岡 孝明; 勝部 幸輝; 小田 順一; 木村 光

  日本結晶学会誌, 1989

  
• Glutathione Synthetaseの結晶化と性質(酵素-蛋白質ペプチド関連酵素, 合成関連酵素-)

  加藤 博章; 山口 宏; 竹島 一哉; 田中 信夫; 西岡 孝明; 勝部 幸輝; 小田 順一

  日本農藝化學會誌, 15 Mar. 1988

  
• グルタチオン合成酵素のX線結晶構造解析 (I)

  山口 宏; 加藤 博章; 畑 安雄; 松浦 良樹; 西岡 孝明; 勝部 幸輝; 木村 光; 小田 順一

  日本結晶学会誌, 1988

  

Presentations

• Structural basis for ABCB1 multi-drug transporter mechanism

  Hiroaki Kato

  SMC complexes: orchestrating diverse genome functions, 16 Oct. 2024, Invited

  
• Structural Biology unveils biological function based on the molecular structure –Physical chemistry of multidrug transporters driven with ATP engine–

  Hiroaki Kato

  The Physical Pharmaceutical Sciences Symposium in the 144th Annual Meeting of the Pharmaceutical Society of Japan, 28 Mar. 2024

  
• X-Ray Structures of CmABCB1 in outward- and inward-facing states reveal a conformational exchange allowing the efflux of multi drug

  KATO Hiroaki

  7th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, 06 Mar. 2018, Invited

  
• Recognition mechanism of the second peroxisomal targeting signal, PTS2 by its receptor complex Pex7p and Pex21p

  KATO Hiroaki

  Consortium of Biological Sciences 2017 (ConBio2017), 06 Dec. 2017, Invited

  
• How ATP binding cassette (ABC) transporter harnesses the energy of ATP binding and hydrolysis to multi drug export

  KATO Hiroaki

  The 55th Annual Meeting of the Biophysical Society of Japan, 19 Sep. 2017

  
• P糖タンパク質のメカニズムから薬物動態の分子構造基盤をさぐる

  加藤 博章

  フォーラム富山「創薬」第４５回研究会, 18 May 2017, Invited

  
• Recognition mechanism of the second peroxisomal targeting signal, PTS2 by its receptor complex Pex7p and Pex21p

  KATO Hiroaki

  2nd International Conference "Peroxisome Function, Function and Metabolism", 20 Jun. 2016, Invited

  
• X線結晶構造解析による生体高分子の時空間階層構造研究の可能性

  加藤 博章

  第29回日本放射光学会年会放射光科学合同シンポジウム, 09 Jan. 2016, Invited

  
• Structural basis for allosteric inhibition of P-glycoprotein homologue CmABCB1

  KATO Hiroaki

  The 3rd international symposium on chemical biology of natural products: target ID and regulation of bioactivity, 28 Oct. 2014

  
• 多剤排出型ABCトランスポーターのX線結晶構造解析

  加藤 博章

  日本薬学会第132年会, 28 Mar. 2012, Invited

  
• X-Ray Crystallography of a Multidrug Exporter-type ABC Transporter

  KATO Hiroaki

  日本農芸化学会2012年度大会, 22 Mar. 2012, Invited

  
• Crystal structure of a multidrug exporter-type ABC transporter

  KATO Hiroaki

  ABC2012 4th FEBS Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, 29 Feb. 2012, Invited

  
• Crystal Structure of a Multi Drug Exporter-type ABC Transporter

  KATO Hiroaki

  ABC2011 in Kyoto -ABC Proteins/Membrane Meso-domains/ES-iPS cells, 17 Nov. 2011, Invited

  
• Structural basis for gibberellin recognition by its receptor GID1

  KATO Hiroaki

  GCOE国際シンポジウム, 23 Nov. 2010

  
• ペルオキシソーム膜タンパク質の運搬体と受容体の相互作用メカニズム

  加藤 博章

  回折構造生物第169委員会第30回研究会, 09 Nov. 2009, Invited

  
• Color Control Mechanism of Firefly Glowing : Crystal Structure and Mechanism of Luminescent Enzyme Luciferase

  KATO Hiroaki

  第22回内藤コンファレンス, 09 Sep. 2008, Invited

  
• 酵素の四次元構造解析

  加藤 博章

  ファルマシア, 01 Jan. 1999

  
• Four-Dimensional Structure Analysis of Enzymatic Reaction

  Kato Hiroaki

  Biophysics, 07 Sep. 1998

  
• ゲンジボタルルシフェラーゼ: MgATP複合体の結晶構造

  中津 亨; 廣川 浩三; 梶山 直樹; 中野 衛一; 加藤 博章

  日本結晶学会誌, 1998

  

Books and Other Publications

• Standard Pharmacutical Sciences Series II 2, Physical Pharmacology III, Instrumental Analysis and Structure Determination

  日本薬学会, Contributor, Chapter 4 X-ray analysis

  東京化学同人, Nov. 2016

  Find Kyoto University's collection of books :

  
• Peroxisomes: Biogenesis, function, and role in human disease

  Hiroaki Kato, Contributor, Structure Biology of Peroxisomal Proteins, Peroxins

  Springer Nature Singapore, 2019

  Find Kyoto University's collection of books :

  
• Works of researchers who invent medicines

  KATO Hiroaki, Joint work, 第４章薬の標的タンパク質の構造を決める

  KAGAKUDOJIN, Mar. 2017, Not refereed

  
• ナノバイオ技術と最新創薬応用研究 (橋田 充, 佐治英郎 編)

  加藤博章; 中津亨; 山口知宏, Contributor, トランスポーターの構造生物学研究とナノバイオ創薬

  遺伝子医学MOOK, 2012, Not refereed

  
• 現代生物科学入門3構造機能生物学「時計制御構造生物学」

  加藤博章

  岩波書店, 27 Jan. 2011, Not refereed

  
• トランスポーター膜タンパク質の構造生物学的研究

  加藤, 博章; 京都大学大学院薬学研究科

  [加藤博章], May 2008, Not refereed

  
• 新しい薬をどう創るか

  加藤 博章, Contributor, 第3章 薬のターゲットタンパク質の構造を決定する

  講談社, Apr. 2007, Not refereed

  Find Kyoto University's collection of books :

  
• ABC proteins

  KATO Hiroaki, Contributor, ABC蛋白質の立体構造研究：現状と課題

  学会出版センター, 2005, Not refereed

  
• アスパラギンシンターゼ（共著）

  加藤 博章

  廣川タンパク質化学,4/ , 262-266, 2003, Not refereed

  
• 日本化学会編実験化学講座（第4版）「生物有機」第4章遺伝子操作（共著）

  加藤 博章

  丸善,27/ , 323-343, 1991, Not refereed

  

Industrial Property Rights

• 特開2012-111718, 特願2010-262291, 多環芳香族化合物

  平竹 潤; 渡辺 文太; 山口 知宏; 崎山 慶太; 中津 亨; 加藤 博章

  

Works

• 第三世代シンクロトン放射光を用いた酵素の極限状態X線結晶構造解析

  From 2001, To 2003

  
• 新たな膜輸送機構の分子基盤

  From 2003

  
• 生理活性糖鎖の構造的基盤と高次生命機能の制御

  From 2003

  
• 藍色細菌の生物時計装置の原子レベルでの解明

  From 2003

  
• 超高分解能Ｘ線構造解析に基づくエンドポリガラツクロナーゼの反応機構の解明

  From 2003

  
• ゲノム科学の知的情報基盤・研究拠点形成

  From 2003

  
• 微小タンパク質結晶Ｘ線回折装置の開発

  From 2003

  
• Molecular Basis of Novel Membrane Transport Mechanism

  From 2003

  
• Knowledge Information Infrastructure for Genome Science

  From 2003

  
• 糖鎖が構造形成におよぼす要因の解析と膜タンパク質結晶化への応用

  From 2001, To 2002

  
• ゲンジボタル・ルシフェラーゼ－反応中間体アナログ複合体のＸ線結晶構造解析

  From 2001, To 2002

  
• 「タンパク3000プロジェクトⅡタンパク質の個別的解析プログラム（翻訳後修飾と輸送）」にかかる「ペルオキシソーム挿入型膜タンパク質の輸送タンパク質装置の構造機能解明と膜タンパク質発現系構築への応用」

  From 2002

  

Awards

• 1994

  日本農芸化学会奨励賞受賞

Media Coverage

• ELCAS Journal

  Kyoto University, 京都大学高大接続事業グローバルサイエンスキャンパスELCAS, 01 Apr. 2015, Pr

  

External funds: Kakenhi

• Structural biology studies on the effect of phospholipid contents for multi-drug transporters

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  Hiroaki Kato

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  構造生物学;構造薬理学;膜タンパク質;リン脂質膜;トランスポーター;多剤耐性;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19333/
• Structural basis for alternating access mechanism of ABC multi-drug pump in lipid membrane

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43040:Biophysics-related

  Kyoto University

  Hiroaki Kato

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  トランスポーター;ATP;膜タンパク質;立体構造解析;多剤認識;多剤耐性;構造生物学;CryoEM;X線結晶解析;構造薬理学;X線解析;立体構造;ＡＴＰ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03222/
• Structural basis for discrimination between multi-drug exporters and lipid floppies

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  Hiroaki KATO

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  構造生物学;多剤耐性;トランスポーター;膜タンパク質;X結晶学;構造生物;X線結晶学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22495/
• Mechanism of contraction and backflow prevention by check valves in ABC transporter pump

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroaki Kato

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  多剤耐性;薬物動態;膜タンパク質;薬物トランスポーター;ATP;X線結晶解析;構造生物学;トランスポーター;X線結晶学;薬理学;薬剤学;多剤排出ポンプ;X線

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03664/
• Development of experimental protocols for NMR analysis of P-glycoprotein structure

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroaki Kato

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  膜タンパク質;NMR;多剤耐性;ATP;トランスポーター;構造生物学;薬理学;好熱性真核生物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15105/
• Structural physiology of regulation mechanism of transport efficiency by P-glycoprotein

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroaki Kato

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  構造生物学;受容体・膜輸送;薬理学;X線結晶学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670014/
• ABC多剤排出トランスポーターと新規特異的阻害剤の結合様式

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  加藤 博章

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  薬学;X線;分子構造;薬理学;タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26102724/
• Elucidation of Multidrug recognition mechanism of ABC transporter and development of its novel inhibitor

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Hiroaki Kato

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  生体膜;構造機能相関;受容体;X線結晶構造解析;生体膜及び受容体;ＡＢＣトランスポーター;多剤耐性;X線結晶解析;薬理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25251006/
• Molecular mechanism of ABC proteins involved in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu Ueda

  From 31 May 2013, To 31 Mar. 2018, Project Closed

  ABC蛋白質;トランスポーター;コレステロール;動脈硬化;アルツハイマー病;増殖シグナル;結晶構造解析;iPS細胞;神経細胞;1分子生物学;構造生物学;膜環境;多能性幹細胞;阻害剤;中枢神経細胞;3次元構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25221203/
• Structural basis for optimization of molecular probe using P-glycoprotein in vivo imaging

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroaki KATO

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  分子イメージング;ABCトランスポーター;X線結晶解析;P糖タンパク質;抗がん剤;Ｘ線結晶解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659018/
• トランスポーターにおけるＡＴＰ駆動力共役メカニズムの立体構造基盤

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  加藤 博章

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  ATP;ABCトランスポーター;膜タンパク質;X線結晶解析;立体構造;膜蛋白質;X線解析;結晶構造;薬物輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23118709/
• トランスポーターにおけるATP駆動力共役メカニズムの立体構造基盤

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  加藤 博章

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  生理学;膜蛋白質;X線解析;結晶構造;薬物輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21118509/
• Physiological substrates and functions of ABC proteins involved in lipid transport

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu UEDA

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  動物生化学;膜輸送タンパク質;ABC蛋白質;動脈硬化;アルツハイマー病;コレステロール;膜タンパク質;神経疾患;生活習慣病;1分子イメージング;ABCタンパク質;善玉コレステロール;ケミカルライブラリー;iPS細胞;ES細胞;1分子観察;トランスポーター;核内受容体;蛋白質相互作用;ACBタンパク質;アルツハイマー;タンパク質精製;プロテアソーム;遺伝病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20228001/
• Struchural biology of membrane protein trabsporters

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroaki KATO

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  ABCトランスポーター;P糖タンパク質;X線結晶解析;単粒子構造解析;膜タンパク質;トランスポーター;構造生物学;電子顕微鏡;多剤耐性;胆汁排出;糖尿病, ABC transporter;P-glycoprotein;X-ray crystalloqraphy;Single Particle Analysis;membrane proteins

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17380066/
• 糖鎖修飾によるタンパク質構造安定化機構の構造生物学的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  加藤 博章

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  糖鎖;タンパク質;酵素;X線結晶構造解析;X線結晶解析;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17046008/
• X線解析を目指した多剤耐性ポンプMDR1の大量発現系の構築と結晶化

  Grant-in-Aid for Exploratory Research

  Kyoto University

  加藤 博章

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  P糖タンパク質;多剤耐性;抗ガン剤;構造生物学;X線結晶学;構造薬理学;膜タンパク質;X線結晶解析;バキュロウイルス;MDR1;結晶化;昆虫細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659012/
• Molecular evolution of plant β-glucosidases deduced from clarification of substrate specificities and catalytic mechanisms of β-diglycosidases (glycosidases specific to disacchalide glycosides)

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kanzo SAKATA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  プリメベロシダーゼ;フルカチンヒドロラーゼ;ビシアニンヒドロラーゼ;ファミリー1グリコシダーゼ;X線結晶構造解析;進化系統樹解析;ジグリコシダーゼ;分子進化;β-プリメベロシダーゼ;ファミリー1 グリコシダーゼ;β-プリメベロシルアミジン;ファミリー1;アフィニティー吸着体;βプリメベロシダーゼ;カラスノエンドウ;ムシカリ;グリコシルアミジン;チャ葉, primeverosidase;furcatin hydrolase;vicianin hydrolase;Family 1 glycosyl hydrolase;X-ray crystallography;phylogenetic analysis;diglycosidase;molecular evolution

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380079/
• Molecular Basis of Novel Membrane Transport Mechanism

  Grant-in-Aid for Creative Scientific Research

  Kyoto University;Akita University

  Nobuya INAGAKI

  From 01 Apr. 2003, To 31 Mar. 2008, Project Closed

  遺伝子;蛋白質;脂質;ABC蛋白質;膜輸送;イオンチャネル, gene;protein;lipid;ABC protein;membrane transport;ion channel

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15GS0301/
• Reaction mechanism based on X-ray crystallography at atomic resolution of endopolygalacturonase

  Grant-in-Aid for Scientific Research (C)

  Hirosaki University

  Kazuo MIYAIRI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  エンドポリガラクツロナーゼ;Stereum purpureum;一般酸塩基触媒;X線結晶構造解析;原子分解能;ペクチナーゼ;一般酸・塩基触媒;原子分解能X線結晶構造解析, endopolygalacturonase;Stereum purpureum;general acid or base catalysis;X ray crystallography;atomic resolution;pectinase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15580072/
• Molecular mechanism for circadian clock molecular machinery at the stomic level

  Grant-in-Aid for Scientific Research (B)

  Nagoya University

  Masahiro ISHIURA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  生物時計;分子装置;ラン藻;時計タンパク質;時計遺伝子;シロイヌナズナ;生物発光;リアルタイムモニタリング;藍色細菌;KaiC;六量体;リン酸化;相互作用;DNAマイクロアレイ;発光レポーター遺伝子;X線結晶構造解析, Biological clock;Molecular machinery;Cyanobacteria;Clock proteins;Clock genes;Arabidopsis;Bioluminescence;Real-time monitoring

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15370004/
• Establishment of A New Group of Glycosyl Hydrolase Family 1 Specific to Disaccharide Glycosides in Plant Kingdom

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kanzo SAKATA

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  β-プリメベロシダーゼ;ジグリコシダーゼ;二糖配糖体特異的加水分解酵素;ファミリー1グリコシダーゼ;フルカチンヒドロラーゼ;ビシアニンヒドロラーゼ;グリコシルアミジン;アフィニティー吸着体;カラスノエンドウ;グリコシダーゼファミリー;フルカチン;ムシカリノキ;生体防御;二糖配糖体;二糖配糖体加水分解酵素;コンビナトリアル;基質特異性, β-primeverosidase;diglycosidase;disaccharide glycoside specific hydrolase;glycosyl hydrolase family 1;furcatin hydrolase;vicianin hydrolase;glycosylamidine;affinity adsorbent

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13460049/
• Forefront X-Ray Crystallography of Enzymes by using the third generation synchrotron radiation

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroaki KATO

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  時間割X線結晶構造解析;超高分解能X線結晶構造解析;シンクロトロン放射光;膜タンパク質;ラウエ回折;タンパク質の結晶化;構造生物学;酵素反応;時分割X線結晶構造解析, Time-resolved crystallography;Ultra-high resolution crystallography;Synchrotron radiation;Membrane protein;Laue diffraction;Protein crystallization;Structural biology;Enzyme reaction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13460046/
• 糖鎖が構造形成におよぼす要因の解析と膜タンパク質結晶化への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  加藤 博章

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  糖鎖修飾;膜タンパク質;結晶化;昆虫細胞;遺伝子発現;多剤耐性;抗癌剤;X線結晶解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13033044/
• ゲンジボタル・ルシフェラーゼ反応中間体アナログ複合体のX線結晶構造解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  加藤 博章

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ルシフェラーゼ;ルシフェリン;ホタル;生物発光;SPring-8;X線結晶構造解析;反応中間体アナログ;酵素阻害剤;オキシルシフェリン;構造生物学;ATP;酵素反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13024275/
• ゲンジボタル・ルシフェラーゼ反応中間体アナログ複合体のX線結晶構造解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Science and Engineering

  理化学研究所

  加藤 博章

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ルシフェラーゼ;ルシフェリン;ホタル;生物発光;SPring-8;X線結晶構造解析;反応中間体アナログ;酵素阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12045269/
• 膜タンパク質結晶化の支援法の開発-ABCタンパク質を中心に

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  理化学研究所

  加藤 博章

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  膜タンパク質の結晶化;ABCトランスポーター;ABCタンパク質;結晶化能;動的光散乱;X線結晶構造解析;糖鎖構造;遷移状態アナログ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11169222/
• Development of practical strategies to support protein crystallization for X-ray crystallography

  Grant-in-Aid for Scientific Research (B).

  RIKEN;Kyoto University

  Hiroaki KATO

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  タンパク質の結晶化;X線結晶構造解析;動的光散乱;結晶化能;遷移状態アナログ;タンパク質化学;γグラタミルシステイン合成酵素;アスパラギン合成酵素;γグルタミルシステイン合成酵素;抗菌性タンパク質, protein crystallization;dynamic light scattering;crystallizability;X-ray crystallography;transition-state analogue;protein chemistry;γ-glutamylcysteine synthetase;asparagine synthetase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10558098/
• Structural basis for bioluminescence - X-ray.structural analysis of firefly luciferase from Luciola cruciata

  Grant-in-Aid for Scientific Research (C)

  RIKEN (The Institute of Physical and Chemical Research);Kyoto University

  Hiroaki KATO

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  ルシフェラーゼ;生物発光;X線結晶構造解析;酵素反応機構;酵素反応中間体;ATP;デヒドロルシフェリン, luciferase;bioluminescence;X-ray structure analysis;crystallization

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10660082/
• ABC蛋白の機能の多様性の分子基盤

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  植田 和光

  From 01 Apr. 1998, To 31 Mar. 2003, Project Closed

  ABCタンパク質;トランスポーター;チャネル;動脈硬化;膜タンパク質;コレステロール;自己免疫疾患;生活習慣病;糖尿病;癌;遺伝病;ATP;レセプター;残耐射性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10217205/
• グルタチオンの介する生体情報機構を探るプローブ合成-生体内グルタチオンレベルを制御する特異的阻害剤の開発-

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Fukui Prefectural University

  小田 順一

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  グルタチオン;γ-グルタミルシステイン合成酵素;遷移状態アナログ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10169236/
• グルタチオンの介する生体情報機を探るプローブ合成-生体内グルタチオンレベルを製御する特異的酵素阻害剤の開発-

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  小田 順一

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  グルタチオン;γ-グルタミルシステイン合成酵素;遷移状態アナログ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09273235/
• Capturing Transit Structures by Kinetic Crystallography

  Grant-in-Aid for international Scientific Research

  KYOTO UNIVERSITY

  Jun'ichi ODA

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  時分割X線結晶構造解析;酵素;蛋白質結晶学;ケージド化合物;反応の同調;ラウエ法;時分割X線結晶解析;タンパク質結晶学, time-resolved crystallography;enzyme;protein crystallography;caged compound;synchronization of reaction;Laue diffraction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044217/
• X線結晶解析とタンパク質工学的方法によるアスパラギン合成酵素の活性中心の決定

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  加藤 博章

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  アスパラギン合成酵素;X線結晶構造解析;部位特異的変異導入;タンパク質工学;酵素反応機構;アミノアシルtRNA合成酵素;酵素反応速度論

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08660108/
• Basic Studies on the Catalytic Reaction Mechanism of Enzymeby Organic Chemical Approaches

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Jun'ichi ODA

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  有機合成化学;タンパク質工学;酵素反応機構;X線結晶構造解析;遷移状態アナログ;グルタチオン;立体特異性;分子認識;酸素反応機構, organic syntesis;protein engineering;enzymatic reaction meehanism;Xray crystallography;transition-state analogue;glutathione;stereospecificity;molecular recognition

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08456060/
• アミド結合の形成を触媒する合成酵素の構造と機能に関する研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  小田 順一

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  γ-グルタミルシステイン合成酵素;グルタチオン合成酵素;アスパラギン合成酵素;遷移状態アナログ阻害剤;X線結晶解析;立体構造

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08219227/
• 合成酵素によるATPの基質活性化機構-アスパラギン合成酵素のX線結晶解析

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  加藤 博章

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  ATP認識;アスパラギン合成酵素;X線結晶解析;グルタチオン合成酵素;アミノアシルtRNA合成酵素;酵素反応;分子進化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07660110/
• Fast crystallography of enzymatic readim in crystals

  Grant-in-Aid for international Scientific Research

  KYOTO UNIVERSITY

  Junichi ODA

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  X線結晶解析;動力学的結晶解析;タンパク質結晶学;低温X線結晶解析;グルタチオン合成酵素;結晶中での酵素反応, X-ray crystallography;Kinetic crystallography;Protein Crystallography;cryo-crystalloqraphy;glutathione synthetase;enzym reaction in crystals

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044195/
• 迅速冷却によるグルタチオン合成酵素反応中の準安定構造のX線結晶解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  加藤 博章

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  迅速冷却;グルタチオン合成酵素;酵素反応;X線結晶解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06760085/
• 遷移状態における酵素複合体の構造解析-グルタチオン合成酵素の構造変化と酵素機能の発現機構-

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  小田 順一

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  遷移状態;遷移状態アナログ;酵素機能;グルタチオン合成酵素;X線結晶解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06240230/
• Reaction Mechanisms and Mode of Action of a Catalytic Antibody and Pseudomonas Lipase

  Grant-in-Aid for General Scientific Research (B)

  KYOTO UNIVERSITY

  Junichi ODA

  From 01 Apr. 1993, To 31 Mar. 1995, Project Closed

  抗体触媒;Pseudomonas属リパーゼ;エステル加水分解;遺伝子クローニング;シャペロン様タンパク質;分子モデリング;活性アルギニン残基;可変領域;生成物阻害;触媒性残基;巻き戻しタンパク質;リパーゼ活性化, Catalytic antibody;Pseudomonas lipase;Ester hydrolysis;Gene cloning;Chaperon-like protein;Molecular modeling

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05453167/
• New Stereospecific Synthesis of Bioactive Compounds Using Lipase as Catalyst in Organic Solvent

  Grant-in-Aid for Developmental Scientific Research (B)

  KYOTO UNIVERSITY

  Junichi ODA

  From 01 Apr. 1992, To 31 Mar. 1995, Project Closed

  リパーゼ;不斉合成;エステル交換反応;不斉変換;有機溶媒;クローニング;活性化因子;大量発現;封入体;リパーゼ活性化因子;シャペロン;Catalytic triad;融合タンパク質;動的速度論的光学分割;光学活性シアノヒドリン類;固定化リパーゼ, lipase;stereospecific synthesis;organic solvent;cyanohydrin;transesterification;lipase activator

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04556014/
• 抗体触媒の精密設計と高度機能改変に関する研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  小田 順一

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  抗体触媒;生成物阻害;不斉加水分解;化学修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04205082/
• Time-Resolved Crystal Structure Analysis of Glutathione Synthetase

  Grant-in-Aid for international Scientific Research

  Osaka University

  Yukiteru KATUBE

  From 01 Apr. 1992, To 31 Mar. 1994, Project Closed

  時間分割X線構造解析;グルタチオン合成酵素;時間分割X線ラウエ法;蛋白質の動的構造;時間分割結晶構造解析;ラウエ法;放射光;フローセル;フラッシュ光反応;変異体酵素;ATP, Time Resolve X-ray Structure Analysis;Glutatuione Synthetase;Laue Method in Time Resolution;Kinetic Protein-Crystallography

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04044103/
• APPLICATION OF GLUTATHIONE SYNTHETASE ON PEPTIDE SYNTHESIS

  Grant-in-Aid for General Scientific Research (C)

  KYOTO UNIVERSITY

  Jun'ichi ODA

  From 01 Apr. 1991, To 31 Mar. 1993, Project Closed

  グルタチオン合成酵素;タンパク質工学;ペプチド合成;部位特異的変異導入;基質認識, GLUTATHIONE SYNTHETASE;PROTEIN ENGINEERING;PEPTIDE SYNTHESIS;SITE-DIRECTED MUTAGENESIS;SUBSTRATE RECOGNITION

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03660138/
• Structural basis of diversed and dynamic substrate recognition mechanism of multidrug transporter by chemical trapping

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Kyoto University

  加藤 博章

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  分子認識;輸送体;クライオ電子顕微鏡;構造生物学;構造薬理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01637/

External funds: others

• 「タンパク3000プロジェクトⅡタンパク質の個別的解析プログラム（翻訳後の修飾と輸送）」にかかる「ペルオキシソーム挿入型膜タンパク質の輸送タンパク質装置の構造機能解明と膜タンパク質発現系構築への応用」

  From 2002, To 2006
• 微小タンパク質結晶Ｘ線回折装置の開発

  科学技術振興調整費

  From 2003, To 2005
• ゲノム科学の知的情報基盤・研究拠点形成

  From 2003, To 2008

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Physical Chemistry for Drug Discovery B

  8202, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Physical Chemistry for Drug Discovery A

  8201, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Structural Biology)

  D153, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry 3 (Structural Chemistry)

  A103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry 1 (Quantum Chemistry)

  A101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry III (Structural Chemistry)

  C103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry I (Quantum Chemistry)

  C101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Science Seminar

  C110, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences II

  6006, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Physical Chemistry

  1206, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Physical Chemistry II

  1212, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Physical Chemistry I

  1211, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Physical Chemistry for Drug Discovery B

  8202, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Structural Biology)

  E805, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Structural Biology)

  D153, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Structural Biology)

  B805, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Structural Biology)

  8153, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Science Seminar

  C110, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry 3 (Structural Chemistry)

  A103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry 1 (Quantum Chemistry)

  A101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry III (Structural Chemistry)

  C103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry I (Quantum Chemistry)

  C101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Physical Chemistry

  1206, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Physical Chemistry II

  1212, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences II

  6006, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry I (Quantum Chemistry)

  C101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Physical Chemistry for Drug Discovery A

  8201, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry III (Structural Chemistry)

  C103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Physical Chemistry I

  1211, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry 1 (Quantum Chemistry)

  A101, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry 3 (Structural Chemistry)

  A103, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Structural Biology)

  B805, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Science Seminar

  C110, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Structural Biology)

  8153, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Structural Biology)

  D153, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmacognosy)

  B803, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  物理化学III（構造化学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  特別実習（構造生物薬学）

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  物理化学３（構造化学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  創薬物理化学エクササイズ２

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  特別実習[構造生物薬学]

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Analytical Chemistry and

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  物理化学４（生物物理化学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  生物物理化学

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  doctoral program

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Physical Chemistry III(Structure Chemistry)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry I(Quantum Chemistey)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Biophysical Chemistry

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Prejudice, Discrimination, and Human Rights

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Medicinal Physical Chemistry Exercise 1

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Science Seminar

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry III (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry I (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Advanced Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Science Seminar

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry III (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry I (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Science Seminar

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry III (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry I (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry 3 (Structural Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry 1 (Quantum Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Structural Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmaceutical Sciences

  Spring, 薬学研究科