Basic Information

Affiliated programs (koza)

• Graduate School of Agriculture, 応用生命科学専攻 生体分子機能講座, 教授

Professional Memberships

• Japan Society for Bioscience, Biotechnology, and Agrochemistry
• The Japanese Biochemical Society
• The Society for Biotechnology, Japan
• The Molecular Biology Society of Japan
• The Japanese Society for Extremophiles
• Japan Trace Nutrients Research Society
• Japanese Society of Enzyme Engineering
• The Vitamin Society of Japan
• Japan Society for Biomedical Research on Trace Elements
• The Kinki Chemical Society Japan
• American Society for Microbiology
• International Society for Extremophiles

Academic Degree

• 工学修士(京都大学)
• 博士（工学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部工業化学科, 卒業

Research History

• From Mar. 2012, To Present

  Kyoto University, Institute for Chemical Research, Professor
• From Apr. 2007, To Feb. 2012

  Kyoto University, Institute for Chemical Research, Associate Professor
• From Oct. 2003, To Mar. 2007

  Kyoto University, Institute for Chemical Research, Associate Professor
• From Dec. 1991, To Sep. 2003

  Kyoto University, Institute for Chemical Research, Instructor
• From Oct. 1996, To Oct. 1998

  University of California, Berkeley, Research Scholar

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-7777-1378

• J-Global ID

  200901065950694958

• Researcher number

  70243087

Website(s) (URL(s))

• https://www.scl.kyoto-u.ac.jp/~mmsicr/mmstojp/Top.html
• http://www.jimu.uji.kyoto-u.ac.jp/open-campus/2020/researcher/CR029.php

researchmap URL

• https://researchmap.jp/read0012425

Research

Research Topics, Overview of the research

• Research Topics

  Investigation and application of molecular basis for expression of microbial functions

• Overview of the research

  Molecular mechanisms underlying biological phenomena in microorganisms are studied using various biochemical approaches. Particular emphasis is placed on the following subjects: analysis of the molecular basis for the adaptation of microorganisms to extreme environments; searching for new microbial enzymes that catalyze unique reactions and analysis of their structures and functions; analysis of the mechanisms of biosynthesis and metabolism of lipid molecules that compose biological membranes and their physiological functions; and analysis of the function of extracellular membrane vesicles and the mechanism of their biogenesis. Based on the findings obtained through these studies, applied microbiological research is also being conducted.

Research Interests

• Molecular Microbial Science
• Applied Microbiology
• Applied Biochemistry

Research Areas

• Life sciences, Applied microbiology
• Life sciences, Applied biochemistry
• Manufacturing technology (mechanical, electrical/electronic, chemical engineering), Applied biofunctional and bioprocess engineering
• Life sciences, Functional biochemistry

Papers

• Compounding deep sea physical impacts on marine microbial motility

  Kelli K. Mullane; Masayoshi Nishiyama; Tatsuo Kurihara; Douglas H. Bartlett

  Frontiers in Marine Science, 23 May 2023

  
• Capsular polysaccharide-mediated protein loading onto extracellular membrane vesicles of a fish intestinal bacterium,Shewanella vesiculosaHM13

  Kouhei Kamasaka; Jun Kawamoto; Taiku Tsudzuki; Yuying Liu; Tomoya Imai; Takuya Ogawa; Tatsuo Kurihara

  bioRxiv, 26 Apr. 2023

  
• Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains

  Kenichi Kawano; Kouhei Kamasaka; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Katsumi Matsuzaki

  Biophysical Chemistry, May 2023

  
• Division of the role and physiological impact of multiple lysophosphatidic acid acyltransferase paralogs

  Takuya Ogawa; Misaki Kuboshima; Nittikarn Suwanawat; Jun Kawamoto; Tatsuo Kurihara

  BMC Microbiology, 06 Oct. 2022, Peer-reviewed, Last author, Corresponding author

  
• Polysaccharide corona: The acetyl-rich envelope wraps the extracellular membrane vesicles and the cells of Shewanella vesiculosa providing adhesiveness

  Angela Casillo; Rossella Di Guida; Domenico Cavasso; Antonietta Stellavato; Diksha Rai; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Tatsuo Kurihara; Chiara Schiraldi; Suvarn Kulkarni; Luigi Paduano; Maria Michela Corsaro

  Carbohydrate Polymers, Aug. 2022, Peer-reviewed

  
• Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation

  Rossella Di Guida; Angela Casillo; Antonietta Stellavato; Soichiro Kawai; Takuya Ogawa; Celeste Di Meo; Jun Kawamoto; Tatsuo Kurihara; Chiara Schiraldi; Maria Michela Corsaro

  Carbohydrate Polymers, Feb. 2022, Peer-reviewed

  
• Membrane Vesicles Produced by Shewanella vesiculosa HM13 as a Prospective Platform for Secretory Production of Heterologous Proteins at Low Temperatures

  Jun Kawamoto; Tatsuo Kurihara

  Methods in Molecular Biology, 2022, Peer-reviewed, Invited, Last author, Corresponding author

  
• Complete Lipooligosaccharide Structure from Pseudoalteromonas nigrifaciens Sq02-Rifr and Study of Its Immunomodulatory Activity

  Rossella Di Guida; Angela Casillo; Antonietta Stellavato; Celeste Di Meo; Soichiro Kawai; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Chiara Schiraldi; Maria Michela Corsaro

  Marine Drugs, 19 Nov. 2021, Peer-reviewed

  
• Initial step of selenite reduction via thioredoxin for bacterial selenoprotein biosynthesis

  Atsuki Shimizu; Ryuta Tobe; Riku Aono; Masao Inoue; Satoru Hagita; Kaito Kiriyama; Yosuke Toyotake; Takuya Ogawa; Tatsuo Kurihara; Kei Goto; N. Tejo Prakash; Hisaaki Mihara

  International Journal of Molecular Sciences, 02 Oct. 2021, Peer-reviewed

  
• Mechanism of protein loading onto extracellular membrane vesicles discovered in a novel bacterial strain

  Tatsuo Kurihara

  Seikagaku, Apr. 2021, Invited, Lead author, Last author, Corresponding author

  
• Identification of a Putative Sensor Protein Involved in Regulation of Vesicle Production by a Hypervesiculating Bacterium, Shewanella vesiculosa HM13

  Fumiaki Yokoyama; Tomoya Imai; Wataru Aoki; Mitsuyoshi Ueda; Jun Kawamoto; Tatsuo Kurihara

  Frontiers in Microbiology, 18 Feb. 2021, Peer-reviewed, Last author, Corresponding author

  
• Elucidation of the mechanism of selective protein transport to bacterial extracellular membrane vesicles and its application to the construction of extracellular protein production platform

  Tatsuo Kurihara

  IFO Research Communications, 2021, Lead author, Last author, Corresponding author

  
• Design of the N-terminus Substituted Curvature-sensing Peptides that Exhibit Highly Sensitive Detection Ability of Bacterial Extracellular Vesicles

  Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Chemical and Pharmaceutical Bulletin, 2021, Peer-reviewed

  
• Characterization of a novel class of glyoxylate reductase belonging to the β-hydroxyacid dehydrogenase family in Acetobacter aceti

  Jakkaphan Kumsab; Ryuta Tobe; Tatsuo Kurihara; Yuu Hirose; Taketo Omori; Hisaaki Mihara

  Bioscience, Biotechnology, and Biochemistry, 01 Nov. 2020, Peer-reviewed

  
• Lysophosphatidic acid acyltransferase from the thermophilic bacterium Thermus thermophilus HB8 displays substrate promiscuity

  Takuya Ogawa; Nittikarn Suwanawat; Yosuke Toyotake; Bunta Watanabe; Jun Kawamoto; Tatsuo Kurihara

  Bioscience, Biotechnology, and Biochemistry, 01 Sep. 2020, Peer-reviewed, Last author, Corresponding author

  
• Development of a Simple and Rapid Method for In Situ Vesicle Detection in Cultured Media

  Kenichi Kawano; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Journal of Molecular Biology, Sep. 2020, Peer-reviewed

  
• Effects of a pyroglutamyl pentapeptide isolated from fermented barley extract on atopic dermatitis-like skin lesions in hairless mouse

  Naruyuki Maruoka; Bunta Watanabe; Daigo Ando; Masahiro Miyashita; Tatsuo Kurihara; Hideki Hokazono

  Bioscience, Biotechnology, and Biochemistry, 02 Aug. 2020, Peer-reviewed

  
• Role of acyl-CoA dehydrogenases from Shewanella livingstonensis Ac10 in docosahexaenoic acid conversion

  Yustina Yusuf; Takuya Ogawa; Jun Kawamoto; Tatsuo Kurihara

  Biochemical and Biophysical Research Communications, Jul. 2020, Peer-reviewed, Last author, Corresponding author

  
• Bioconversion From Docosahexaenoic Acid to Eicosapentaenoic Acid in the Marine Bacterium Shewanella livingstonensis Ac10

  Takuya Ogawa; Kazuki Hirose; Yustina Yusuf; Jun Kawamoto; Tatsuo Kurihara

  Frontiers in Microbiology, 26 May 2020, Peer-reviewed, Last author, Corresponding author

  
• A Novel Lysophosphatidic Acid Acyltransferase of Escherichia coli Produces Membrane Phospholipids with a cis-vaccenoyl Group and Is Related to Flagellar Formation

  Yosuke Toyotake; Masayoshi Nishiyama; Fumiaki Yokoyama; Takuya Ogawa; Jun Kawamoto; Tatsuo Kurihara

  Biomolecules, 11 May 2020, Peer-reviewed, Last author, Corresponding author

  
• Genetic characterization and functional implications of the gene cluster for selective protein transport to extracellular membrane vesicles of Shewanella vesiculosa HM13

  Kouhei Kamasaka; Jun Kawamoto; Chen Chen; Fumiaki Yokoyama; Tomoya Imai; Takuya Ogawa; Tatsuo Kurihara

  Biochemical and Biophysical Research Communications, May 2020, Peer-reviewed, Last author, Corresponding author

  
• Detailed Structural Characterization of the Lipooligosaccharide from the Extracellular Membrane Vesicles of Shewanella vesiculosa HM13

  Rossella Di Guida; Angela Casillo; Fumiaki Yokoyama; Jun Kawamoto; Tatsuo Kurihara; Maria Michela Corsaro

  Marine Drugs, 27 Apr. 2020, Peer-reviewed

  
• Isolation of a Novel Bacterial Strain Capable of Producing Abundant Extracellular Membrane Vesicles Carrying a Single Major Cargo Protein and Analysis of Its Transport Mechanism

  Chen Chen; Jun Kawamoto; Soichiro Kawai; Akihiro Tame; Chiaki Kato; Tomoya Imai; Tatsuo Kurihara

  Frontiers in Microbiology, 14 Jan. 2020, Peer-reviewed, Last author, Corresponding author

  
• Development of a regulatable low-temperature protein expression system using the psychrotrophic bacterium, Shewanella livingstonensis Ac10, as the host

  Soichiro Kawai; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara

  Bioscience, Biotechnology, and Biochemistry, 02 Nov. 2019, Peer-reviewed, Last author, Corresponding author

  
• Corrigendum to “A novel 1-acyl-sn-glycerol-3-phosphate O-acyltransferase homolog for the synthesis of membrane phospholipids with a branched-chain fatty acyl group in Shewanella livingstonensis Ac10”

  Yosuke Toyotake; Hyun-Nam Cho; Jun Kawamoto; Tatsuo Kurihara

  Biochemical and Biophysical Research Communications, Feb. 2019, Last author, Corresponding author

  
• Structural elucidation of a novel lipooligosaccharide from the cold-adapted bacterium OMVs producer Shewanella sp. HM13

  A. Casillo; R. Di Guida; S. Carillo; C. Chen; K. Kamasaka; J. Kawamoto; T. Kurihara; M. M. Corsaro

  Marine Drugs, Jan. 2019, Peer-reviewed

  
• Synthesis of omega-3 long-chain polyunsaturated fatty acid-rich triacylglycerols in an endemic goby, Gymnogobius isaza, from Lake Biwa, Japan

  T. Suito; K. Nagao; M. Hatano; K. Kohashi; A. Tanabe; H. Ozaki; J. Kawamoto; T. Kurihara; T. Mioka; K. Tanaka; Y. Hara; M. Umeda

  Journal of Biochemistry, Aug. 2018, Peer-reviewed

  
• Purification and characterization of 1-acyl-sn-glycerol-3-phosphate acyltransferase with a substrate preference for polyunsaturated fatty acyl donors from the eicosapentaenoic acid-producing bacterium Shewanella livingstonensis Ac10

  T. Ogawa; A. Tanaka; J. Kawamoto; T. Kurihara

  Journal of Biochemistry, Jul. 2018, Peer-reviewed, Last author, Corresponding author

  
• A novel 1-acyl-sn-glycerol-3-phosphate O-acyltransferase homolog for the synthesis of membrane phospholipids with a branched-chain fatty acyl group in Shewanella livingstonensis Ac10

  Yosuke Toyotake; Hyun-Nam Cho; Jun Kawamoto; Tatsuo Kurihara

  Biochemical and Biophysical Research Communications, 07 Jun. 2018, Peer-reviewed, Last author, Corresponding author

  
• Dimer-monomer equilibrium of human HSP27 is influenced by the in-cell macromolecular crowding environment and is controlled by fatty acids and heat

  Satoshi B. Sato; Miwa Sugiura; Tatsuo Kurihara

  Biochimica et Biophysica Acta - Proteins and Proteomics, 01 May 2018, Peer-reviewed, Last author

  
• 細菌におけるω3長鎖高度不飽和脂肪酸の生合成と生理機能

  栗原 達夫; 川本 純; 小川 拓哉

  ビタミン, Sep. 2017, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Selective fluorescence detection method for selenide and selenol using monochlorobimane

  Takeshi Imai; Tatsuo Kurihara; Nobuyoshi Esaki; Hisaaki Mihara

  ANALYTICAL BIOCHEMISTRY, Sep. 2017, Peer-reviewed

  
• Synthesis and Functional Assessment of a Novel Fatty Acid Probe, omega-Ethynyl Eicosapentaenoic Acid Analog, to Analyze the in Vivo Behavior of Eicosapentaenoic Acid

  Tomohisa Tokunaga; Bunta Watanabe; Sho Sato; Jun Kawamoto; Tatsuo Kurihara

  BIOCONJUGATE CHEMISTRY, Aug. 2017, Peer-reviewed, Last author, Corresponding author

  
• Proteomic insights of psychrophiles

  Jun Kawamoto; Tatsuo Kurihara; Nobuyoshi Esaki

  Psychrophiles: From Biodiversity to Biotechnology: Second Edition, 01 Jul. 2017, Peer-reviewed

  
• Characterization of extracellular membrane vesicles of an Antarctic bacterium, Shewanella livingstonensis Ac10, and their enhanced production by alteration of phospholipid composition

  Fumiaki Yokoyama; Jun Kawamoto; Tomoya Imai; Tatsuo Kurihara

  EXTREMOPHILES, Jul. 2017, Peer-reviewed, Last author, Corresponding author

  
• Diversity of Bacterial Membrane Phospholipids : Their Biosynthesis and Functions

  栗原 達夫

  膜, 2017, Invited, Lead author, Last author, Corresponding author

  
• A phosphoporin homolog plays a critical role in the dissimilatory iron-respiration linked to iron (III) reduction by a cold-adapted bacterium, Shewanella livingstonensis Ac10

  Y. Ohke; S. Maruyama; J. Tarui; Y. Wang; J. Kawamoto; T. Kurihara

  Trace Nutrients Research, Dec. 2016, Peer-reviewed, Last author, Corresponding author

  
• Regulatory mechanism of membrane protein production in an EPA-producing bacterium, Shewanella livingstonensis Ac10

  M. Sugiura; J. Park; J. Kawamoto; N. Esaki; T. Kurihara

  Trace Nutrients Research, Dec. 2016, Peer-reviewed, Last author, Corresponding author

  
• Development of a versatile method for targeted gene deletion and insertion by using the pyrF gene in the psychrotrophic bacterium, Shewanella livingstonensis Ac10

  Tomokazu Ito; Chunjie Gong; Jun Kawamoto; Tatsuo Kurihara

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Dec. 2016, Peer-reviewed, Last author, Corresponding author

  
• 低温菌の低温環境への適応メカニズム

  川本 純; 栗原 達夫

  生物工学, Aug. 2015, Peer-reviewed, Invited, Last author

  
• Alkyl hydroperoxide reductase enhances the growth of Leuconostoc mesenteroides lactic acid bacteria at low temperatures

  Seitaro Goto; Jun Kawamoto; Satoshi B. Sato; Takashi Iki; Itaru Watanabe; Kazuyuki Kudo; Nobuyoshi Esaki; Tatsuo Kurihara

  AMB EXPRESS, Feb. 2015, Peer-reviewed, Last author, Corresponding author

  
• Nar is the dominant dissimilatory nitrate reductase under high pressure conditions in the deep-sea denitrifier Pseudomonas sp MT-1

  Yuji Oikawa; Yui Sinmura; Hikari Ishizaka; Ryota Midorikawa; Jun Kawamoto; Tatsuo Kurihara; Chiaki Kato; Koki Horikoshi; Hideyuki Tamegai

  JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2015, Peer-reviewed

  
• Glutathione contributes to the efflux of selenium from hepatoma cells

  Takeshi Imai; Tatsuo Kurihara; Nobuyoshi Esaki; Hisaaki Mihara

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2014, Peer-reviewed

  
• Characterization of a thermostable 2,4-diaminopentanoate dehydrogenase from Fervidobacterium nodosum Rt17-B1

  Sadanobu Fukuyama; Hisaald Mihara; Ryoma Miyake; Makoto Ueda; Nobuyoshi Esaki; Tatsuo Kurihara

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, May 2014, Peer-reviewed, Last author, Corresponding author

  
• Global Identification of Genes Affecting Iron-Sulfur Cluster Biogenesis and Iron Homeostasis

  Ryota Hidese; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF BACTERIOLOGY, Mar. 2014, Peer-reviewed

  
• Reciprocal Modulation of Surface Expression of Annexin A2 in a Human Umbilical Vein Endothelial Cell-Derived Cell Line by Eicosapentaenoic Acid and Docosahexaenoic Acid

  Jungha Park; Takayuki Yamaura; Jun Kawamoto; Tatsuo Kurihara; Satoshi B. Sato

  PLOS ONE, Jan. 2014, Peer-reviewed

  
• Chemical approach to analyze the physiological function of phospholipids with polyunsaturated fatty acyl chain

  Tatsuo Kurihara; Jun Kawamoto

  Yakugaku Zasshi, 2014, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Binding modes of DL-2-haloacid dehalogenase revealed by crystallography, modeling and isotope effects studies

  Agata Siwek; Rie Omi; Ken Hirotsu; Keiji Jitsumori; Nobuyoshi Esaki; Tatsuo Kurihara; Piotr Paneth

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Dec. 2013, Peer-reviewed

  
• Regulation of Cytochrome c- and Quinol Oxidases, and Piezotolerance of Their Activities in the Deep-Sea Piezophile Shewanella violacea DSS12 in Response to Growth Conditions

  Yoshie Ohke; Ayaka Sakoda; Chiaki Kato; Yoshihiro Sambongi; Jun Kawamoto; Tatsuo Kurihara; Hideyuki Tamegai

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2013, Peer-reviewed

  
• 細菌細胞膜の新しいマイクロドメイン

  栗原達夫; 川本純

  化学と生物, Jun. 2013, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453

  Satoshi B. Sato; Jungha Park; Jun Kawamoto; Sho Sato; Tatsuo Kurihara

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Feb. 2013, Peer-reviewed, Last author

  
• 地球環境と微生物

  栗原達夫

  海洋化学研究, 2013, Invited, Lead author, Last author, Corresponding author

  
• Physiological Roles of Phospholipids Containing Polyunsaturated Fatty Acids in Bacteria

  KAWAMOTO Jun; KURIHARA Tatsuo

  Oleoscience, 2013, Invited, Last author, Corresponding author

  
• Functional Analysis of an Eicosapentaenoic Acid Biosynthesis Protein Orf2 from a Psychrotrophic Bacterium, Shewanella livingstonensis Ac10

  Gong, C; Kawamoto, J; Esaki, N; Kurihara, T

  Trace Nutrients Research, Dec. 2012, Peer-reviewed, Last author, Corresponding author

  
• Characterization of 1-Acyl-sn-Glycerol-3-Phosphate Acyltransferase from a Polyunsaturated Fatty Acid-Producing Bacterium, Shewanella livingstonensis Ac10

  Cho, H.-N; Kasai, W; Kawamoto, J; Esaki, N; Kurihara, T

  Trace Nutrients Research, Dec. 2012, Peer-reviewed, Last author, Corresponding author

  
• Pseudomonas putida PydR, a RutR-like transcriptional regulator, represses the dihydropyrimidine dehydrogenase gene in the pyrimidine reductive catabolic pathway

  Ryota Hidese; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF BIOCHEMISTRY, Oct. 2012, Peer-reviewed

  
• Eicosapentaenoic acid facilitates the folding of an outer membrane protein of the psychrotrophic bacterium, Shewanella livingstonensis Ac10

  Xian-Zhu Dai; Jun Kawamoto; Satoshi B. Sato; Nobuyoshi Esaki; Tatsuo Kurihara

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, Peer-reviewed, Last author, Corresponding author

  
• Occurrence of a Bacterial Membrane Microdomain at the Cell Division Site Enriched in Phospholipids with Polyunsaturated Hydrocarbon Chains

  Sho Sato; Jun Kawamoto; Satoshi B. Sato; Bunta Watanabe; Jun Hiratake; Nobuyoshi Esaki; Tatsuo Kurihara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2012, Peer-reviewed, Last author, Corresponding author

  
• Substrate Specificity of Fluoroacetate Dehalogenase: An Insight from Crystallographic Analysis, Fluorescence Spectroscopy, and Theoretical Computations

  Tomonori Nakayama; Takashi Kamachi; Keiji Jitsumori; Rie Omi; Ken Hirotsu; Nobuyoshi Esaki; Tatsuo Kurihara; Kazunari Yoshizawa

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2012, Peer-reviewed

  
• Identification of cold-inducible inner membrane proteins of the psychrotrophic bacterium, Shewanella livingstonensis Ac10, by proteomic analysis

  Jungha Park; Jun Kawamoto; Nobuyoshi Esaki; Tatsuo Kurihara

  EXTREMOPHILES, Mar. 2012, Peer-reviewed, Last author, Corresponding author

  
• Eicosapentaenoic acid plays a role in stabilizing dynamic membrane structure in the deep-sea piezophile Shewanella violacea: A study employing high-pressure time-resolved fluorescence anisotropy measurement

  Keiko Usui; Toshiki Hiraki; Jun Kawamoto; Tatsuo Kurihara; Yuichi Nogi; Chiaki Kato; Fumiyoshi Abe

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Mar. 2012, Peer-reviewed

  
• Function of FADH2-dependent 2-haloacrylate hydratase from a 2-chloroacrylate-utilizing bacterium, Burkholderia sp. WS

  VASUDEVAN Anoop; FUJITA Michiyo; KURATA Atsushi; KURATA Atsushi; KAWAMOTO Jun; ESAKI Nobuyoshi; KURIHARA Tatsuo

  Trace Nutr Res, 22 Dec. 2011, Peer-reviewed, Last author, Corresponding author

  
• Identification of novel mammalian phospholipids containing threonine, aspartate, and glutamate as the base moiety

  Taketo Omori; Ai Honda; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Nov. 2011, Peer-reviewed

  
• Thermal Stability of Cytochrome c(5) of Pressure-Sensitive Shewanella livingstonensis

  Misa Masanari; Satoshi Wakai; Hideyuki Tamegai; Tatsuo Kurihara; Chiaki Kato; Yoshihiro Sambongi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 2011, Peer-reviewed

  
• Mammalian Selenocysteine Lyase Is Involved in Selenoprotein Biosynthesis

  Suguru Kurokawa; Masanori Takehashi; Hiromitsu Tanaka; Hisaaki Mihara; Tatsuo Kurihara; Seigo Tanaka; Kristina Hill; Raymond Burk; Nobuyoshi Esaki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Aug. 2011, Peer-reviewed

  
• Favourable effects of eicosapentaenoic acid on the late step of the cell division in a piezophilic bacterium, Shewanella violacea DSS12, at high- hydrostatic pressures

  Jun Kawamoto; Takako Sato; Kaoru Nakasone; Chiaki Kato; Hisaaki Mihara; Nobuyoshi Esaki; Tatsuo Kurihara

  ENVIRONMENTAL MICROBIOLOGY, Aug. 2011, Peer-reviewed

  
• Physiological function of polyunsaturated fatty acid-contanining phospholipids in cold-adapted microorganisms

  KAWAMOTO Jun; KURIHARA Tatsuo

  Bioscience & industry, 01 Jul. 2011

  
• Piezotolerance of the Respiratory Terminal Oxidase Activity of the Piezophilic Shewanella violacea DSS12 as Compared with Non-Piezophilic Shewanella Species

  Hideyuki Tamegai; Yuuya Ota; Minami Haga; Hiroki Fujimori; Chiaki Kato; Yuichi Nogi; Jun Kawamoto; Tatsuo Kurihara; Yoshihiro Sambongi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2011, Peer-reviewed

  
• A Mechanistic Analysis of Enzymatic Degradation of Organohalogen Compounds

  Tatsuo Kurihara

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2011, Peer-reviewed

  
• Escherichia coli Dihydropyrimidine Dehydrogenase Is a Novel NAD-Dependent Heterotetramer Essential for the Production of 5,6-Dihydrouracil

  Ryota Hidese; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF BACTERIOLOGY, Feb. 2011, Peer-reviewed

  
• Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line

  Satoshi B. Sato; Sho Sato; Jun Kawamoto; Tatsuo Kurihara

  PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Jan. 2011, Peer-reviewed

  
• In vitro Refolding of an OmpA Homolog, a Major Cold-Inducible Outer Membrane Protein, from a Psychrotrophic Bacterium, Shewanella livingstonensis Ac10

  Dai, X.-Z; Kawamoto, J; Esaki, N; Kurihara, T

  Journal of Japanese Society for Extremophiles, 10, 90-96, 2011, Peer-reviewed, Last author, Corresponding author

  
• The Distribution of Phosphatidyl-D-serine in the Rat

  Taketo Omori; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 2010, Peer-reviewed

  
• 2-Haloacrylate Hydratase, a New Class of Flavoenzyme That Catalyzes the Addition of Water to the Substrate for Dehalogenation

  Amr M. Mowafy; Tatsuo Kurihara; Atsushi Kurata; Tadashi Uemura; Nobuyoshi Esaki

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Sep. 2010, Peer-reviewed

  
• Specific transfer of selenium in selenoprotein biosynthesis

  Tobe R; Mihara H; Kurihara T; Esaki N

  Biomed. Res. Trace Elements,, Sep. 2010

  
• Crystallization and preliminary X-ray analysis of L-azetidine-2-carboxylate hydrolase from Pseudomonas sp strain A2C

  Mayuko Toyoda; Keiji Jitsumori; Bunzo Mikami; Lawrence P. Wackett; Tatsuo Kurihara; Nobuyoshi Esaki

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jun. 2010, Peer-reviewed

  
• Reaction Mechanism and Molecular Basis for Selenium/Sulfur Discrimination of Selenocysteine Lyase

  Rie Omi; Suguru Kurokawa; Hisaaki Mihara; Hideyuki Hayashi; Masaru Goto; Ikuko Miyahara; Tatsuo Kurihara; Ken Hirotsu; Nobuyoshi Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2010, Peer-reviewed

  
• Biosynthesis and function of long-chain polyunsaturated fatty acids in cold-adapted bacteria

  栗原達夫; 川本純; 江崎信芳

  Protein, nucleic acid and enzyme, 01 Jan. 2010

  
• IscS Functions as a Primary Sulfur-donating Enzyme by Interacting Specifically with MoeB and MoaD in the Biosynthesis of Molybdopterin in Escherichia coli

  Wanjiao Zhang; Alexander Urban; Hisaaki Mihara; Silke Leimkuehler; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2010, Peer-reviewed

  
• 17.セレノシステインリアーゼの機能(第418回研究協議会研究発表要旨,ビタミンB研究委員会)

  黒川 優; 三原 久明; 栗原 達夫; 江崎 信芳

  ビタミン, 2010

  
• 2-Haloacrylate hydratase is a bifunctional enzyme with NADH-dependent FAD reductase activity

  Mowafy AM; Kurihara T; Esaki N

  微量栄養素研究, 2010, Peer-reviewed

  
• Biosynthesis and function of long-chain polyunsaturated fatty acids in cold-adapted bacteria

  T. Kurihara; J. Kawamoto; N. Esaki

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2010, Peer-reviewed

  
• Possible Role of Red Blood Cells in Selenocysteine Metabolism

  IMAI Takeshi; MIHARA Hisaaki; KURIHARA Tatsuo; ESAKI Nobuyoshi

  Trace Nutr Res, 20 Dec. 2009, Peer-reviewed

  
• Roles of K151 and D180 in L-2-Haloacid Dehalogenase from Pseudomonas sp YL: Analysis by Molecular Dynamics and Ab Initio Fragment Molecular Orbital Calculations

  Takashi Nakamura; Azusa Yamaguchi; Hirotaka Kondo; Hirofumi Watanabe; Tatsuo Kurihara; Nobuyoshi Esaki; Shuichi Hirono; Shigenori Tanaka

  JOURNAL OF COMPUTATIONAL CHEMISTRY, Dec. 2009, Peer-reviewed

  
• Selenocysteine Is Selectively Taken Up by Red Blood Cells

  Takeshi Imai; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Dec. 2009, Peer-reviewed

  
• 好冷性細菌の低温適応に関わるタンパク質とリン脂質

  栗原達夫; 川本純; 江崎信芳

  生化学, Dec. 2009, Invited

  
• Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombe

  Masaru Goto; Takae Yamauchi; Nobuo Kamiya; Ikuko Miyahara; Tohru Yoshimura; Hisaaki Mihara; Tatsuo Kurihara; Ken Hirotsu; Nobuyoshi Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2009, Peer-reviewed

  
• 低温細菌における高度不飽和脂肪酸含有リン脂質の機能

  栗原達夫

  生化学, Aug. 2009

  
• 低温下で機能する酵素

  栗原達夫; 江崎信芳

  化学工学 = Chemical engineering, 05 Jul. 2009

  
• Occurrence of phosphatidyl-D-serine in the rat cerebrum

  Taketo Omori; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2009, Peer-reviewed

  
• Identification of Proteins Interacting with Selenocysteine Lyase

  Ryuta Tobe; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2009, Peer-reviewed

  
• Production of a chiral organohalogen compound by using a novel enzyme catalyzing asymmetric reduction

  KURIHARA Tatsuo

  Bioscience & industry, 01 Apr. 2009

  
• X-Ray Crystallographic and Mutational Studies of Fluoroacetate Dehalogenase from Burkholderia sp Strain FA1

  Keiji Jitsumori; Rie Omi; Tatsuo Kurihara; Atsushi Kurata; Hisaaki Mihara; Ikuko Miyahara; Ken Hirotsu; Nobuyoshi Esaki

  JOURNAL OF BACTERIOLOGY, Apr. 2009, Peer-reviewed

  
• Serine Racemase with Catalytically Active Lysinoalanyl Residue

  Takae Yamauchi; Masaru Goto; Hui-Yuan Wu; Takuma Uo; Tohru Yoshimura; Hisaaki Mihara; Tatsuo Kurihara; Ikuko Miyahara; Ken Hirotsu; Nobuyoshi Esaki

  JOURNAL OF BIOCHEMISTRY, Apr. 2009, Peer-reviewed

  
• Eicosapentaenoic Acid Plays a Beneficial Role in Membrane Organization and Cell Division of a Cold-Adapted Bacterium, Shewanella livingstonensis Ac10

  Jun Kawamoto; Tatsuo Kurihara; Kentaro Yamamoto; Makiko Nagayasu; Yasushi Tani; Hisaaki Mihara; Masashi Hosokawa; Takeshi Baba; Satoshi B. Sato; Nobuyoshi Esaki

  JOURNAL OF BACTERIOLOGY, Jan. 2009, Peer-reviewed

  
• The Catalytic Mechanism of Fluoroacetate Dehalogenase: A Computational Exploration of Biological Dehalogenation

  Takashi Kamachi; Tomonori Nakayama; Osamu Shitamichi; Keiji Jitsumori; Tatsuo Kurihara; Nobuyoshi Esaki; Kazunari Yoshizawa

  CHEMISTRY-A EUROPEAN JOURNAL, 2009, Peer-reviewed

  
• Proteins and phospholipids involved in cold-adaptation of psychrotrophic bacteria

  Tatsuo Kurihara; Jun Kawamoto; Nobuyoshi Esaki

  Seikagaku, 2009, Peer-reviewed

  
• Cold adaptation of eicosapentaenoic acid-less mutant of Shewanella livingstonensis Ac10 involving uptake and remodeling of synthetic phospholipids containing various polyunsaturated fatty acids

  Sho Sato; Tatsuo Kurihara; Jun Kawamoto; Masashi Hosokawa; Satoshi B. Sato; Nobuyoshi Esaki

  EXTREMOPHILES, Nov. 2008, Peer-reviewed

  
• The iscS gene deficiency affects the expression of pyrimidine metabolism genes

  Hisaaki Mihara; Ryota Hidese; Masahiro Yamane; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2008, Peer-reviewed

  
• Enzymology of Amino Acid Production

  Nobuyoshi Esaki; Shigeru Nakamori; Tatsuo Kurihara; Setsuo Furuyoshi; Kenji Soda

  Biotechnology: Second, Completely Revised Edition, 07 May 2008, Peer-reviewed

  
• Isomerizations

  Nobuyoshi Esaki; T. Kurihara; K. Soda

  Enzyme Catalysis in Organic Synthesis: Second Edition, 15 Apr. 2008, Peer-reviewed

  
• Thioredoxin Reductase 1 Is Important for Selenoprotein Biosynthesis in HeLa Cells

  Kurokawa S; Mihara H; Yokoyama I; Mochizuki M; Yodoi J; Tamura T; Kurihara T; Esaki N

  Biomedical research on trace elements, 01 Apr. 2008, Peer-reviewed

  
• Functional analysis of two homologous mouse selenophosphate synthetases.

  Abe K; Ebata I; Kazuoka T; Mihara H; Kurihara. T; Esaki N

  Biomedical Research on Trace Elements, 01 Apr. 2008, Peer-reviewed

  
• Production of (S)-2-chloropropionate by asymmetric reduction of 2-chloroacrylate with 2-haloacrylate reductase coupled with glucose dehydrogenase

  Atsushi Kurata; Michiyo Fujita; Amr M. Mowafy; Harumi Kamachi; Tatsuo Kurihara; Nobuyoshi Esaki

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Apr. 2008, Peer-reviewed

  
• 8.新規ピリミジンデヒドロゲナーゼ(第413回研究協議会研究発表要旨,ビタミンB研究委員会)

  江崎 信芳; 秀瀬 涼太; 三原 久明; 栗原 達夫

  ビタミン, 2008

  
• 1.大腸菌のシステインデスルフラーゼCsdAの機能(第410回研究協議会研究発表要旨,ビタミンB研究委員会)

  江崎 信芳; 張 万皎; 三原 久明; 栗原 達夫

  ビタミン, 2008

  
• Role of cysteine desulfurase IscS in the biosynthesis of molybdopterin

  Zhang Wanjiao; Mihara Hisaaki; Kurihara Tatsuo; Esaki Nobuyoshi

  VITAMINS, 2008

  
• Bacterial hydrolytic dehalogenases and related enzymes: Occurrences, reaction mechanisms, and applications

  Tatsuo Kurihara; Nobuyoshi Esaki

  CHEMICAL RECORD, 2008, Peer-reviewed

  
• Proteomic studies of psychrophilic microorganisms

  Tatsuo Kurihara; Nobuyoshi Esaki

  Psychrophiles: From Biodiversity to Biotechnology, 2008, Peer-reviewed

  
• Proteomic studies of an Antarctic cold-adapted bacterium, Shewanella livingstonensis Ac10, for global identification of cold-inducible proteins

  Jun Kawamoto; Tatsuo Kurihara; Masanari Kitagawa; Ikunoshin Kato; Nobuyoshi Esaki

  EXTREMOPHILES, Nov. 2007, Peer-reviewed

  
• Purification of branched-chain amino acid aminotransferase from Helicobacter pylori NCTC11637

  M. Saito; K. Nishimura; S. Wakabayashi; T. Kurihara; Y. Nagata

  AMINO ACIDS, Sep. 2007, Peer-reviewed

  
• Construction of a low-temperature protein expression system using a cold-adapted bacterium, Shewanella sp strain Ac10, as the host

  Ryoma Miyake; Jun Kawamoto; Yun-Lin Wei; Masanari Kitagawa; Ikunoshin Kato; Tatsuo Kurihara; Nobuyoshi Esaki

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Aug. 2007, Peer-reviewed

  
• Expression, purification and preliminary X-ray characterization of DL-2-haloacid dehalogenase from Methylobacterium sp CPA1

  Rie Omi; Keiji Jitsumori; Takahiro Yamauchi; Susumu Ichiyama; Tatsuo Kurihara; Nobuyoshi Esaki; Nobuo Kamiya; Ken Hirotsu; Ikuko Miyahara

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Jul. 2007, Peer-reviewed

  
• Expression, purification and preliminary X-ray characterization of DL-2-haloacid dehalogenase from Methylobacterium sp. CPA1

  Rie Omi; Keiji Jitsumori; Takahiro Yamauchi; Susumu Ichiyama; Tatsuo Kurihara; Nobuyoshi Esaki; Nobuo Kamiya; Ken Hirotsu; Ikuko Miyahara

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 15 Jun. 2007, Peer-reviewed

  
• Alanine racemase from Helicobacter pylori NCTC 11637: Purification, characterization and gene cloning

  Makoto Saito; Katsushi Nishimura; Yuichiro Hasegawa; Tomomitsu Shinohara; Sadao Wakabayashi; Tatsuo Kurihara; Morio Ishizuka; Yoko Nagata

  LIFE SCIENCES, Jan. 2007, Peer-reviewed

  
• Selenoprotein Biosynthesis and Selenium-Specific Enzymes

  MIHARA Hisaaki; KUROKAWA Suguru; OMI Rie; KURIHARA Tatsuo; HIROTSU Ken; ESAKI Nobuyoshi

  Biomed Res Trace Elem, 31 Dec. 2006, Peer-reviewed

  
• Enzymatic synthesis of L-pipecolic acid by Delta(1)-piperideine-2-carboxylate reductase from Pseudomonas putida

  Hisashi Muramatsu; Hisaaki Mihara; Mari Yasuda; Makoto Ueda; Tatsuo Kurihara; Nobuyoshi Esaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 2006, Peer-reviewed

  
• Mechanism of the reaction catalyzed by DL-2-haloacid dehalogenase as determined from kinetic isotope effects

  E Papajak; RA Kwiecien; J Rudzinski; D Sicinska; R Kaminski; L Szatkowski; T Kurihara; N Esaki; P Paneth

  BIOCHEMISTRY, May 2006, Peer-reviewed

  
• 6.含硫tRNA生合成酵素(第405回研究協議会研究発表要旨,ビタミンB研究委員会)

  江崎 信芳; 三原 久明; 郭 美善; 村上 佳子; 栗原 達夫

  ビタミン, 2006

  
• 低温でタンパク質を作る新技術

  栗原達夫; 江崎信芳

  化学と生物 , 44, 41370, 2006

  
• New technique to produce proteins at low temperatures.

  Kurihara T; Esaki N

  Kagaku to Seibutsu, 44, 4-6, 2006

  
• RNAi-mediated knock down of mammalian selenocysteine lyase

  Kurokawa S; Mihara H; Takehashi M; Tanaka S; Kurihara T; Esaki N

  Biomedical research on trace elements, 31 Dec. 2005, Peer-reviewed

  
• Protein Interaction between Selenophosphate Synthetase and IscS

  ABE Katsumasa; EBATA Ichiro; KAZUOKA Takayuki; MIHARA Hisaaki; KURIHARA Tatsuo; ESAKI Nobuyoshi

  Biomed Res Trace Elem, 31 Dec. 2005, Peer-reviewed

  
• Crystal structures of Delta(1)-piperideine-2-carboxylate/Delta(1)-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases - Conformational change, substrate recognition, and stereochemistry of the reaction

  M Goto; H Muramatsu; H Mihara; T Kurihara; N Esaki; R Omi; Miyahara, I; K Hirotsu

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2005, Peer-reviewed

  
• A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins

  H Muramatsu; H Mihara; M Goto; Miyahara, I; K Hirotsu; T Kurihara; N Esaki

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Jun. 2005, Peer-reviewed

  
• 2-Haloacrylate reductase, a novel enzyme of the medium chain dehydrogenase/reductase superfamily that catalyzes the reduction of a carbon-carbon double bond of unsaturated organohalogen compounds

  A Kurata; T Kurihara; H Kamachi; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2005, Peer-reviewed

  
• N-methyl-L-amino acid dehydrogenase from Pseudomonas putida - A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily

  H Mihara; H Muramatsu; R Kakutani; M Yasuda; M Ueda; T Kurihara; N Esaki

  FEBS JOURNAL, Mar. 2005, Peer-reviewed

  
• The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent Delta(1)-piperideine-2-carboxylate/Delta(1)-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline

  H Muramatsu; H Mihara; R Kakutani; M Yasuda; M Ueda; T Kurihara; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2005, Peer-reviewed

  
• Expression analysis of mammalian selenocysteine lyase

  KUROKAWA S; MIHARA H; KURIHARA T; ESAKI N

  Biomed Res Trace Elem, 01 Oct. 2004, Peer-reviewed

  
• Enzymatic synthesis of N-methyl-L-phenylalanine by a novel enzyme, N-methyl-L-amino acid dehydrogenase, from Pseudomonas putida

  H Muramatsu; H Mihara; R Kakutani; M Yasuda; M Ueda; T Kurihara; N Esaki

  TETRAHEDRON-ASYMMETRY, Sep. 2004, Peer-reviewed

  
• Asymmetric reduction of 2-chloroacrylic acid to (S)-2-chloropropionic acid by a novel reductase from Burkholderia sp WS

  A Kurata; T Kurihara; H Kamachi; N Esaki

  TETRAHEDRON-ASYMMETRY, Sep. 2004, Peer-reviewed

  
• Reactivity of asparagine residue at the active site of the D105N mutant of fluoroacetate dehalogenase from Moraxella sp. B.

  Susumu Ichiyama; Tatsuo Kurihara; Yoshifumi Kogure; Susumu Tsunasawa; Haruhiko Kawasaki; Nobuyoshi Esaki

  Biochimica et biophysica acta, 08 Apr. 2004

  
• Reactivity of asparagine residue at the active site of the D105N mutant of fluoroacetate dehalogenase from Moraxella sp B

  S Ichiyama; T Kurihara; Y Kogure; S Tsunasawa; H Kawasaki; N Esaki

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Apr. 2004, Peer-reviewed

  
• Bioconversion of organohalogen compounds with microbial enzymes: Mechanistic analysis of the enzyme reactions and their application

  Tatsuo Kurihara

  Nippon Nogeikagaku Kaishi, 2004

  
• Effects of Selenium Deficiency on the Expression of Selenoprotein mRNAs in Mouse Brain

  Kuwana E; Kurokawa S; Mihara H; Kurihara T; Yoshimura T; Esaki N

  Biomedical research on trace elements, 30 Dec. 2003, Peer-reviewed

  
• A novel esterase from a psychrotrophic bacterium, Acinetobacter sp strain no. 6, that belongs to the amidase signature family

  YL Wei; T Kurihara; T Suzuki; N Esaki

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Sep. 2003, Peer-reviewed

  
• Purification, characterization, and gene cloning of a novel fluoroacetate dehalogenase from Burkholderia sp FA1

  T Kurihara; T Yamauchi; S Ichiyama; H Takahata; N Esaki

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Sep. 2003, Peer-reviewed

  
• Mass spectrometric analysis of the reactions catalyzed by L-2-haloacid dehalogenase mutants and implications for the roles of the catalytic amino acid residues

  YF Li; T Kurihara; S Ichiyama; M Miyagi; S Tsunasawa; N Esaki

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Sep. 2003, Peer-reviewed

  
• A new DL-2-haloacid dehalogenase acting on 2-haloacid amides: purification, characterization, and mechanism

  C Park; T Kurihara; T Yoshimura; K Soda; N Esaki

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Sep. 2003, Peer-reviewed

  
• Cloning, heterologous expression, renaturation, and characterization of a cold-adapted esterase with unique primary structure from a psychrotroph Pseudomonas sp strain B11-1

  T Suzuki; T Nakayama; DW Choo; Y Hirano; T Kurihara; T Nishino; N Esaki

  PROTEIN EXPRESSION AND PURIFICATION, Aug. 2003, Peer-reviewed

  
• Assembly of iron-sulfur clusters mediated by cysteine desulfurases, IscS, CsdB and CSD, from Escherichia coli

  Tatsuo Kurihara; Hisaaki Mihara; Shin Ichiro Kato; Tohru Yoshimura; Nobuyoshi Esaki

  Biochimica et Biophysica Acta - Proteins and Proteomics, Apr. 2003, Peer-reviewed

  
• Enhanced selenium tolerance and accumulation in transgenic Arabidopsis expressing a mouse selenocysteine lyase

  M Pilon; JD Owen; GF Garifullina; T Kurihara; H Mihara; N Esaki; EAH Pilon-Smits

  PLANT PHYSIOLOGY, Mar. 2003, Peer-reviewed

  
• Erratum: Characterization of a NifS-like chloroplast protein from arabidopsis. Implications for its role in sulfur and selenium metabolism (Plant Physiology (2002) 130 (1309-1318))

  E. A.H. Pilon-Smits; G. F. Garifullina; S. Abdel-Ghany; S. I. Kato; H. Mihara; K. L. Hale; J. L. Burkhead; N. Esaki; T. Kurihara; M. Pilon

  Plant Physiology, 01 Jan. 2003, Peer-reviewed

  
• Characterization of a NifS-like chloroplast protein from arabidopsis. Implications for its role in sulfur and selenium metabolism

  Elizabeth A.H. Pilon-Smits; Gulnara F. Garifullina; Salah Abdel-Ghany; Shin Ichiro Kato; Hisaaki Mihara; Kerry L. Hale; Jason L. Burkhead; Nobuyoshi Esaki; Tatsuo Kurihara; Marinus Pilon

  Plant Physiology, 01 Nov. 2002, Peer-reviewed

  
• Primary structure and catalytic properties of a cold-active esterase from a psychrotroph, Acinetobacter sp strain no. 6. isolated from Siberian soil

  T Suzuki; T Nakayama; T Kurihara; T Nishino; N Esaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2002, Peer-reviewed

  
• Network of protein-protein interactions among iron-sulfur cluster assembly proteins in Escherichia coli

  Umechiyo Tokumoto; Shinobu Nomura; Yoshiko Minami; Hisaaki Mihara; Shin Ichiro Kato; Tatsuo Kurihara; Nobuyoshi Esaki; Hiroshi Kanazawa; Hiroshi Matsubara; Yasuhiro Takahashi

  Journal of Biochemistry, May 2002, Peer-reviewed

  
• Catalysis-linked inactivation of fluoroacetate dehalogenase by ammonia: A novel approach to probe the active-site environment

  S Ichiyama; T Kurihara; M Miyagi; A Galkin; S Tsunasawa; H Kawasaki; N Esaki

  JOURNAL OF BIOCHEMISTRY, May 2002, Peer-reviewed

  
• A cold-active esterase with a substrate preference for vinyl esters from a psychrotroph, Acinetobacter sp strain no. 6: gene cloning, purification, and characterization

  T Suzuki; T Nakayama; T Kurihara; T Nishino; N Esaki

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Feb. 2002, Peer-reviewed

  
• Structure of external aldimine of Escherichia coli CsdB, an IscS/NifS homolog: Implications for its specificity toward selenocysteine

  Hisaaki Mihara; Tomomi Fujii; Shin ichiro Kato; Tatsuo Kurihara; Yasuo Hata; Nobuyoshi Esaki

  Journal of Biochemistry, 2002, Peer-reviewed

  
• セレン代謝におけるNifSホモログの役割

  三原 久明; 加藤 伸一郎; Gerard M. Lacourciere; Thressa C. Stadtman; 栗原 達夫; 徳本 梅千代; 高橋 康弘; 江崎 信芳

  微量栄養素研究 , 19, 15-18, 2002, Peer-reviewed

  
• Role of Cysteine Desulfurase in the Biosynthesis of Formate Dehydrogenase H Containing Mo, Molybdopterin, Selenocysteine, and Fe4S4 Cluster.

  MIHARA H; KATO S; KURIHARA T; YOSHIMURA T; ESAKI N; LACOURCIERE G M; STADTMAN T C

  Biomed Res Trace Elem, 30 Dec. 2001, Peer-reviewed

  
• Chlorine kinetic isotope effect on the fluoroacetate dehalogenase reaction

  A Lewandowicz; D Sicinska; J Rudzinski; S Ichiyama; T Kurihara; N Esaki; P Paneth

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2001, Peer-reviewed

  
• Cold-active lipolytic activity of psychrotrophic Acinetobacter sp strain no. 6

  T Suzuki; T Nakayama; T Kurihara; T Nishino; N Esaki

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Aug. 2001, Peer-reviewed

  
• Development of Mass Spectrometry and Its Application to Analysis of Enzyme Reaction Mechanism

  KURIHARA Tatsuo; ESAKI Nobuyoshi

  KAGAKU TO SEIBUTSU, 25 Mar. 2001

  
• Screening and identification of a protein interacting with IscU

  Kato S; Mihara H; Kurihara T; Yoshimura T; Esaki N

  Proceedings Symposium on Trace Nutrients Research, 2001, Peer-reviewed

  
• Development of mass spectrometry and its application to analysis of enzyme reaction mechanism.

  Kurihara T; Esaki N

  Kagaku to Seibutsu, 39, 165-170, 2001

  
• Novel catalytic mechanism of nucleophilic substitution by asparagine residue involving cyanoalanine intermediate revealed by mass spectrometric monitoring of an enzyme reaction

  S Ichiyama; T Kurihara; YF Li; Y Kogure; S Tsunasawa; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2000, Peer-reviewed

  
• Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae

  Y Shimoni; T Kurihara; M Ravazzola; M Amherdt; L Orci; R Schekman

  JOURNAL OF CELL BIOLOGY, Nov. 2000, Peer-reviewed

  
• Biogenesis of iron-sulfur clusters

  KURIHARA Tatsuo; ESAKI Nobuyoshi

  生化学, 25 Oct. 2000

  
• Biogenesis of iron-sulfur clusters

  T Kurihara; N Esaki

  SEIKAGAKU, Oct. 2000, Peer-reviewed

  
• Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms

  T Kurihara; N Esaki; K Soda

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Sep. 2000, Peer-reviewed

  
• Escherichia coli NifS-like proteins provide selenium in the pathway for the biosynthesis of selenophosphate

  GM Lacourciere; H Mihara; T Kurihara; N Esaki; TC Stadtman

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2000, Peer-reviewed

  
• Kinetic and mutational studies of three NifS homologs from Escherichia coli: Mechanistic difference between L-cysteine desulfurase and L-selenocysteine lyase reaction

  H Mihara; T Kurihara; T Yoshimura; N Esaki

  JOURNAL OF BIOCHEMISTRY, Apr. 2000, Peer-reviewed

  
• cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase - Candidate for selenium delivery protein in selenoprotein synthesis

  H Mihara; T Kurihara; T Watanabe; T Yoshimura; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2000, Peer-reviewed

  
• Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae

  T Kurihara; S Hamamoto; RE Gimeno; CA Kaiser; R Schekman; T Yoshihisa

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2000, Peer-reviewed

  
• Structure of a NifS homologue: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase

  T Fujii; M Maeda; H Mihara; T Kurihara; N Esaki; Y Hata

  BIOCHEMISTRY, Feb. 2000, Peer-reviewed

  
• Gene cloning, purification, and characterization of two cyanobacterial NifS homologs driving iron-sulfur cluster formation

  Shin Ichiro Kato; Hisaaki Mihara; Tatsuo Kurihara; Tohru Yoshimura; Nobuyoshi Esaki

  Bioscience, Biotechnology and Biochemistry, 2000, Peer-reviewed

  
• 元素状硫黄と元素状セレンのバイオジェネシスを司るNifS相同タンパク質:鉄-硫黄クラスター形成能の解明

  加藤 伸一郎; 三原 久明; 栗原 達夫; 吉村 徹; 江崎 信芳

  微量栄養素研究, 2000, Peer-reviewed

  
• DL-2-haloacid dehalogenase from Pseudomonas sp 113 is a new class of dehalogenase catalyzing hydrolytic dehalogenation not involving enzyme-substrate ester intermediate

  Nardi-Dei, V; T Kurihara; C Park; M Miyagi; S Tsunasawa; K Soda; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1999, Peer-reviewed

  
• A nifS-like gene, csdB, encodes an Escherichia coli counterpart of mammalian selenocysteine lyase - Gene cloning, purification, characterization and preliminary x-ray crystallographic studies

  H Mihara; M Maeda; T Fujii; T Kurihara; Y Hata; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1999, Peer-reviewed

  
• Role of lysine 39 of alanine racemase from Bacillus stearothermophilus that binds pyridoxal 5 '-phosphate - Chemical rescue studies of Lys(39)-> Ala mutant

  A Watababe; Y Kurokawa; T Yoshimura; T Kurihara; K Soda; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1999, Peer-reviewed

  
• Cold-active serine alkaline protease from the psychrotrophic bacterium Shewanella strain Ac10: Gene cloning and enzyme purification and characterization

  L Kulakova; A Galkin; T Kurihara; T Yoshimura; N Esaki

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Feb. 1999, Peer-reviewed

  
• 鉄硫黄クラスター研究の新展開 −電子伝達だけではない、鉄硫黄クラスターの機能−

  栗原 達夫

  生物工学会誌, 77, 247, 1999, Peer-reviewed

  
• セレノシステインリアーゼ活性を持つ大腸菌 NifSホモログの構造と機能

  江崎 信芳; 三原 久明; 栗原 達夫; 吉村 徹; 左右田 健次

  微量栄養素研究 , 16, 13-16, 1999, Peer-reviewed

  
• Lipase from an Alaskan Psychrotroph, Pseudomonas sp. B11-1: Gene cloning, protein characterization and homology modelling

  Andrey Galkin; Dong-Won Choo; Takeshi Suzuki; Tatsuo Kurihara; Tohru Yoshimura; Nobuyoshi Esaki

  Nippon Nogeikagaku Kaishi, 1999, Peer-reviewed

  
• Reaction mechanism of fluoroacetate dehalogenase from Moraxella sp. B

  JQ Liu; T Kurihara; S Ichiyama; M Miyagi; S Tsunasawa; H Kawasaki; K Soda; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1998, Peer-reviewed

  
• X-ray structure of a reaction intermediate of L-2-haloacid dehalogenase with L-2-chloropropionamide

  YF Li; Y Hata; T Fujii; T Kurihara; N Esaki

  JOURNAL OF BIOCHEMISTRY, Jul. 1998, Peer-reviewed

  
• Crystal structures of reaction intermediates of L-2-haloacid dehalogenase and implications for the reaction mechanism

  YF Li; Y Hata; T Fujii; T Hisano; M Nishihara; T Kurihara; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1998, Peer-reviewed

  
• Purification, characterization, and mechanism of a flavin mononucleotide-dependent 2-nitropropane dioxygenase from Neurospora crassa

  N Gorlatova; M Tchorzewski; T Kurihara; K Soda; N Esaki

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 1998, Peer-reviewed

  
• A cold-adapted lipase of an Alaskan psychrotroph, Pseudomonas sp. strain B11-1: Gene cloning and enzyme purification and characterization

  DW Choo; T Kurihara; T Suzuki; K Soda; N Esaki

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Feb. 1998, Peer-reviewed

  
• L-2-ハロ酸デハロゲナーゼの反応複合体解析

  畑 安雄; 李 永福; 藤井 知実; 栗原 達夫; 江崎 信芳

  日本結晶学会誌, 1998

  
• 大腸菌由来NIFS相同酵素の結晶構造

  藤井 知実; 前田 匡毅; 三原 久明; 栗原 達夫; 江崎 信芳; 畑 安雄

  日本結晶学会誌, 1998

  
• Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities - Gene cloning, purification, and characterization of a novel pyridoxal enzyme

  H Mihara; T Kurihara; T Yoshimura; K Soda; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1997, Peer-reviewed

  
• Bacterial DL-2-haloacid dehalogenase from Pseudomonas sp. strain 113: Gene cloning and structural comparison with D- and L-2-haloacid dehalogenases

  NardiDei, V; T Kurihara; C Park; N Esaki; K Soda

  JOURNAL OF BACTERIOLOGY, Jul. 1997, Peer-reviewed

  
• 2-halo acid dehalogenases

  K Soda; N Esaki; T Kurihara

  FASEB JOURNAL, Jul. 1997, Peer-reviewed

  
• Paracatalytic inactivation of L-2-haloacid dehalogenase from Pseudomonas sp. YL by hydroxylamine - Evidence for the formation of an ester intermediate

  JQ Liu; T Kurihara; M Miyagi; S Tsunasawa; M Nishihara; N Esaki; K Soda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1997, Peer-reviewed

  
• 大腸菌由来システインスルフィン酸デスルフィナーゼIIの結晶構造解析

  藤井 知実; 前田 匡毅; 三原 久明; 栗原 達夫; 江崎 信芳; 畑 安雄

  日本結晶学会誌, 1997

  
• L-2-ハロ酸デハロゲナーゼの反応機構解析―エステル中間体の構造

  畑 安雄; 李 永福; 藤井 知実; 栗原 達夫; 江崎 信芳

  日本結晶学会誌, 1997

  
• Bacterial 2-haloacid dehalogenases: Structures and catalytic properties

  K Soda; T Kurihara; JQ Liu; NardiDei, V; C Park; M Miyagi; S Tsunasawa; N Esaki

  PURE AND APPLIED CHEMISTRY, Nov. 1996, Peer-reviewed

  
• Crystal structure of L-2-haloacid dehalogenase from Pseudomonas sp YL - An alpha/beta hydrolase structure that is different from the alpha/beta hydrolase fold

  T Hisano; Y Hata; T Fujii; JQ Liu; T Kurihara; N Esaki; K Soda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1996, Peer-reviewed

  
• Crystallization and preliminary X-ray crystallographic studies of L-2-haloacid dehalogenase from Pseudomonas sp. YL

  T Hisano; Y Hata; T Fujii; JQ Liu; T Kurihara; N Esaki; K Soda

  PROTEINS-STRUCTURE FUNCTION AND GENETICS, Apr. 1996, Peer-reviewed

  
• L-2-ハロ酸デハロゲナーゼの活性発現時の構造変化

  久野 玉雄; 畑 安雄; 藤井 知実; 西原 光洋; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本結晶学会誌, 1996

  
• ハロゲン化脂肪族化合物の酵素的分解の仕組み

  栗原 達夫

  バイオサイエンスとインダストリー, 54, 506-507, 1996

  
• Nitroalkane-oxidizing Enzymes (proceedings)

  Kurihara T; Gorlatova N; Tchorzewski M; Esaki N; Soda K

  Flavins and Flavoproteins 1996, , 251-260, 1996, Peer-reviewed

  
• OVEREXPRESSION AND FEASIBLE PURIFICATION OF THERMOSTABLE L-2-HALO ACID DEHALOGENASE OF PSEUDOMONAS SP YL

  JQ LIU; T KURIHARA; NARDIDEI, V; T OKAMURA; N ESAKI; K SODA

  BIODEGRADATION, Sep. 1995, Peer-reviewed

  
• REACTION-MECHANISM OF L-2-HALOACID DEHALOGENASE OF PSEUDOMONAS SP. YL - IDENTIFICATION OF ASP(10) AS THE ACTIVE-SITE NUCLEOPHILE BY O-18 INCORPORATION EXPERIMENTS

  JQ LIU; T KURIHARA; M MIYAGI; N ESAKI; K SODA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1995, Peer-reviewed

  
• COMPREHENSIVE SITE-DIRECTED MUTAGENESIS OF L-2-HALO ACID DEHALOGENASE TO PROBE CATALYTIC AMINO-ACID-RESIDUES

  T KURIHARA; JQ LIU; NARDIDEI, V; H KOSHIKAWA; N ESAKI; K SODA

  JOURNAL OF BIOCHEMISTRY, Jun. 1995, Peer-reviewed

  
• L-2-ハロ酸デハロゲナーゼの結晶構造

  久野 玉雄; 畑 安雄; 藤井 知実; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本結晶学会誌, 1995

  
• 3-KETOACYL COA THIOLASES OF A YEAST, CANDIDA-TROPICALIS - PROPERTIES AND FUNCTIONS

  A TANAKA; T KURIHARA; N KANAYAMA; H ATOMI; M UEDA

  ENZYME ENGINEERING XII, 1995, Peer-reviewed

  
• UNIQUE PRIMARY STRUCTURE OF 2-NITROPROPANE DIOXYGENASE FROM HANSENULA-MRAKII

  M TCHORZEWSKI; T KURIHARA; N ESAKI; K SODA

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Dec. 1994, Peer-reviewed

  
• Overexpression and Rapid Purification of L-2-Halo Acid Dehalogenase of Pseudomonas putida No. 109.

  LIU J‐Q; KURIHARA T; NARDI‐DEI V; ESAKI N; SODA K

  Bull Inst Chem Res Kyoto Univ, Nov. 1994, Peer-reviewed

  
• 2 KINDS OF 2-HALO ACID DEHALOGENASES FROM PSEUDOMONAS SP YL INDUCED BY 2-CHLOROACRYLATE AND 2-CHLOROPROPIONATE

  AKMQ HASAN; H TAKADA; H KOSHIKAWA; JQ LIU; T KURIHARA; N ESAKI; K SODA

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 1994, Peer-reviewed

  
• COMPARATIVE-STUDIES OF GENES ENCODING THERMOSTABLE L-2-HALO ACID DEHALOGENASE FROM PSEUDOMONAS SP STRAIN-YL, OTHER DEHALOGENASES, AND 2 RELATED HYPOTHETICAL PROTEINS FROM ESCHERICHIA-COLI

  NARDIDEI, V; T KURIHARA; T OKAMURA; JQ LIU; H KOSHIKAWA; H OZAKI; Y TERASHIMA; N ESAKI; K SODA

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Sep. 1994, Peer-reviewed

  
• RECONSIDERATION OF THE ESSENTIAL ROLE OF A HISTIDINE RESIDUE OF L-2-HALO ACID DEHALOGENASE

  JQ LIU; T KURIHARA; N ESAKI; K SODA

  JOURNAL OF BIOCHEMISTRY, Aug. 1994, Peer-reviewed

  
• PURIFICATION AND CHARACTERIZATION OF THERMOSTABLE AND NONTHERMOSTABLE 2-HALOACID DEHALOGENASES WITH DIFFERENT STEREOSPECIFICITIES FROM PSEUDOMONAS SP STRAIN YL

  JQ LIU; T KURIHARA; AKMQ HASAN; NARDIDEI, V; H KOSHIKAWA; N ESAKI; K SODA

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jul. 1994, Peer-reviewed

  
• FUNGAL THERMOSTABLE ALPHA-DIALKYLAMINO ACID AMINOTRANSFERASE - OCCURRENCE, PURIFICATION AND CHARACTERIZATION

  N ESAKI; M WATANABE; T KURIHARA; K SODA

  ARCHIVES OF MICROBIOLOGY, Feb. 1994, Peer-reviewed

  
• A 340-nm chromophore of nitroalkane oxidase from Fusarium oxysporum

  T Kurihara; N Esaki; K Soda; N Ohishi

  FLAVINS AND FLAVOPROTEINS 1993, 1994, Peer-reviewed

  
• Genomic DNA structure of a unique flavoprotein, 2-nitropropane dioxygenase from Hansenula mrakii

  M Tchorzewski; T Kurihara; N Esaki; K Soda

  FLAVINS AND FLAVOPROTEINS 1993, 1994, Peer-reviewed

  
• 有機ハロゲン化合物を分解する酵素 −デハロゲナーゼの構造と反応機構−

  栗原 達夫

  化学と生物 , 32, 695-697, 1994, Peer-reviewed

  
• Molecular evolution of yeast thiolase isozymes

  Naoki Kanayama; Mitsuyoshi Ueda; Haruyuki Atomi; Tatsuo Kurihara; Atsuo Tanaka

  Journal of Fermentation and Bioengineering, 1994, Peer-reviewed

  
• COMPARISON OF MOLECULAR-STRUCTURES AND REGULATION OF BIOSYNTHESIS OF UNIQUE THIOLASE ISOZYMES LOCALIZED ONLY IN PEROXISOMES OF N-ALKANE-UTILIZABLE YEAST, CANDIDA-TROPICALIS

  N KANAYAMA; M UEDA; H ATOMI; T KURIHARA; J KONDO; Y TERANISHI; A TANAKA

  JOURNAL OF FERMENTATION AND BIOENGINEERING, 1994, Peer-reviewed

  
• ハロ酸デハロゲナーゼの結晶学的研究

  久野 玉雄; 畑 安雄; 藤井 知実; 劉 吉泉; Nardi-Dei Vincenzo; 越川 博元; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本結晶学会誌, 1993

  
• PEROXISOMAL ACETOACETYL-COA THIOLASE OF AN N-ALKANE-UTILIZING YEAST, CANDIDA-TROPICALIS

  T KURIHARA; M UEDA; N KANAYAMA; J KONDO; Y TERANISHI; A TANAKA

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Dec. 1992, Peer-reviewed

  
• PHYSIOLOGICAL ROLES OF ACETOACETYL-COA THIOLASE IN N-ALKANE-UTILIZABLE YEAST, CANDIDA-TROPICALIS - POSSIBLE CONTRIBUTION TO ALKANE DEGRADATION AND STEROL BIOSYNTHESIS

  T KURIHARA; M UEDA; N KAMASAWA; M OSUMI; A TANAKA

  JOURNAL OF BIOCHEMISTRY, Dec. 1992, Peer-reviewed

  
• IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF THIOLASES, BETA-OXIDATION ENZYMES OF AN N-ALKANE-UTILIZABLE YEAST, CANDIDA-TROPICALIS

  N KAMASAWA; N NAITO; T KURIHARA; Y KAMADA; M UEDA; A TANAKA; M OSUMI

  CELL STRUCTURE AND FUNCTION, Jun. 1992, Peer-reviewed

  
• BETA-OXIDATION OF BUTYRATE, THE SHORT-CHAIN-LENGTH FATTY-ACID, OCCURS IN PEROXISOMES IN THE YEAST CANDIDA-TROPICALIS

  T KURIHARA; M UEDA; H OKADA; N KAMASAWA; N NAITO; M OSUMI; A TANAKA

  JOURNAL OF BIOCHEMISTRY, Jun. 1992, Peer-reviewed

  
• LOCALIZATION OF CANDIDA-TROPICALIS PEROXISOMAL ISOCITRATE LYASE HIGHLY EXPRESSED IN PEROXISOME-PROLIFERATED SACCHAROMYCES-CEREVISIAE

  Y KAMADA; M UEDA; H ATOMI; K ODA; T KURIHARA; N NAITO; R UKITA; N KAMASAWA; M OSUMI; A TANAKA

  JOURNAL OF FERMENTATION AND BIOENGINEERING, 1992, Peer-reviewed

  
• GENES ENCODING PEROXISOMAL ENZYMES ARE NOT NECESSARILY ASSIGNED ON THE SAME CHROMOSOME OF AN NORMAL-ALKANE-UTILIZABLE YEAST CANDIDA-TROPICALIS

  Y FUKUDA; H ATOMI; T KURIHARA; M HIKIDA; M UEDA; A TANAKA

  FEBS LETTERS, Jul. 1991, Peer-reviewed

  
• PEROXISOMAL ACETOACETYL-COA THIOLASE AND 3-KETOACYL-COA THIOLASE FROM AN NORMAL-ALKANE-UTILIZING YEAST, CANDIDA-TROPICALIS - PURIFICATION AND CHARACTERIZATION

  T KURIHARA; M UEDA; A TANAKA

  JOURNAL OF BIOCHEMISTRY, Sep. 1989, Peer-reviewed

  
• Occurrence and possible roles of acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase in peroxisomes of an n-alkane-grown yeast, Candida tropicalis

  T. Kurihara; M. Ueda; A. Tanaka

  FEBS Letters, 29 Feb. 1988, Peer-reviewed

  

Misc.

• 低温菌Shewanella livingstonensis Ac10の細胞分裂関連タンパク質の機能解析

  永久由利絵; 青柳美穂; 川本純; 江崎信芳; 栗原達夫

  京都大学低温物質科学研究センター誌, 2013

  
• 低温菌Shewanella livingstonensis Ac10の細胞分裂に関与するABCトランスポーターの解析

  青柳美穂; 川本純; 栗原達夫; 江崎信芳

  日本農芸化学会大会講演要旨集, 2011

  
• 低温菌Shewanella livingstonensis Ac10の細胞分裂におけるEPA含有リン脂質の生理機能

  青柳美穂; 川本純; 栗原達夫; 江崎信芳

  生化学, 2010

  
• 深海底泥由来単離株51-CSのメンブランベシクルの特性解明

  福井瑞季; 倉田淳志; 三好柚紀; 山崎思乃; 今井友也; 栗原達夫; 上垣浩一

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 発酵食品に関する微生物のメンブランベシクルの特性の解明

  倉田淳志; 清原昇悟; 宮崎綾乃; 三好柚紀; 山崎思乃; 今井友也; 栗原達夫; 上垣浩一

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 相模湾由来単離株51-CSのメンブランベシクルの特性の解析

  福井瑞季; 倉田淳志; 三好柚紀; 山崎思乃; 今井友也; 栗原達夫; 上垣浩一

  日本生物工学会大会講演要旨集, 2019

  
• 低温菌Shewanella livingstonensis Ac10におけるドコサヘキサエン酸からエイコサペンタエン酸への変換機構の解析

  廣瀬 和樹; 小川 拓哉; 川本 純; 栗原 達夫

  極限環境生物学会第19会例会, Dec. 2018

  
• 大腸菌のリン脂質生合成に関与する新規アシル基転移酵素の同定と機能解析

  栗原達夫

  第454回ビタミンB研究協議会, Oct. 2018

  
• PURIFICATION AND CHARACTERIZATION OF 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE THAT PRODUCES EICOSAPENTAENOIC ACID-CONTAINING PHOSPHOLIPIDS

  小川 拓哉; 田中 麻子; 川本 純; 栗原 達夫

  Extremophiles 2018, 16 Sep. 2018

  
• Extracellular membrane vesicles of Shewanella sp. HM13: Analysis of their cargo loading mechanism

  T. Kurihara

  12th International Congress of Extremophiles, Sep. 2018

  
• 低温菌Pseudoalteromonas sp. Sq02株を用いたタンパク質低温生産システムの開発

  河合総一郎; Aken Puti Wanguyun; 川本 純; 小川拓哉; 栗原達夫

  日本生化学会第65回近畿支部例会, 26 May 2018

  
• 低温菌 Shewanella sp. HM13 におけるベシクル分泌関連タンパク質の探索

  横山 文秋; 川本 純; 陳 晨; 今井 友也; 栗原 達夫

  日本農芸化学会 2018 年度大会, 16 Mar. 2018

  
• 低温菌 Shewanella sp. HM13の膜小胞輸送による選択的タンパク質分泌に関与する遺伝子の探索

  釜阪 紘平; Chen CHEN; 横山 文秋; 川本 純; 今井 友也; 小川 拓哉; 栗原 達夫

  日本農芸化学会 2018 年度大会, 16 Mar. 2018

  
• 低温菌における機能性多価不飽和脂肪酸の細胞内局在の可視化

  川本純; 徳永智久; 渡辺文太; 小川拓哉; 栗原達夫

  日本農芸化学会2018年度大会，名古屋, 16 Mar. 2018

  
• 好熱菌Thermus thermophilus由来リゾホスファチジン酸アシル基転移酵素の基質特異性の解析

  小川拓哉; SUWANAWAT Nittikarn; 豊竹洋佑; 渡辺文太; 川本純; 栗原達夫

  日本農芸化学会2018年度大会，名古屋, 16 Mar. 2018

  
• EPA 生産菌Shewanella livingstonensis Ac10 のリゾホスファチジン酸アシル基転移酵素の精製と 特性評価

  小川 拓哉; 田中 麻子; 川本 純; 栗原 達夫

  特殊環境微生物セミナー 2017, Oct. 2017

  
• Biosynthesis of phospholipids containing eicosapentaenoic acid and development of a molecular probe to analyze its in vivo function

  T. Kurihara

  Japan-Italy Bilateral Symposium, Oct. 2017, Invited

  
• エイコサペンタエン酸含有リン脂質の生合成を担う細菌アシル基転移酵素の精製と特性解析

  栗原達夫

  第450回ビタミンB研究協議会, Oct. 2017

  
• EPA アナログを用いたクリックケミストリーによる EPA の生理機能解析

  川本 純; 徳永智久; 渡辺文太; 栗原達夫

  日本脂質生化学会, 15 Jun. 2017

  
• エイコサペンタエン酸をリン脂質に導入するアシル基転移酵素の特性

  栗原達夫

  第34回 日本微量栄養素学会学術集会, Jun. 2017

  
• 細菌型リゾホスファチジン酸アシル基転移酵素の精製とキャラクタリゼーション

  小川 拓哉; 田中麻子; Nittikarn Suwanawat; 川本純; 栗原達夫

  第64回日本生化学会近畿支部例会, May 2017

  
• 細菌におけるエイコサペンタエン酸の生理機能

  栗原達夫; 川本純; 渡辺文太; 小川拓哉

  日本農芸化学会2017年度大会，京都, 20 Mar. 2017

  
• Interaction between proteins involved in the biosynthesis of EPA-containing phospholipids in a psychrotrophic bacterium, Shewanella livingstonensis Ac10

  Chen Tsai-Min; Ryutaro OGURA; Takuya OGAWA; Jun KAWAMOTO; Tatsuo KURIHARA

  日本農芸化学会 2017 年度大会, 17 Mar. 2017

  
• 低温性 Shewanella 属細菌由来リゾホスファチジン酸アシル基転移酵素 PlsC の機能解析

  田中麻子; 小川 拓哉; 川本 純; 栗原 達夫

  日本農芸化学会 2017 年度大会, 17 Mar. 2017

  
• Analysis of a protein secretion mechanism via the membrane vesicle production of a cold-adapted bacterium, Shewanella sp. HM13

  Chen Chen; Soichiro KAWAI; Jun Kawamoto; Tomoya Imai; Tatsuo kurihara

  日本農芸化学会 2017 年度大会, 17 Mar. 2017

  
• 低温菌 Shewanella livingstonensis Ac10 の鉄呼吸における Phosphoporin ホモログの生理機能

  川本 純; 大毛淑恵; 丸山沙織; 樽井惇; 王玉; 川本純; 栗原達夫

  第17回極限環境生物学会 2016年度年会, 25 Nov. 2016

  
• 低温菌 Shewanella livingstonensis Ac10 による菌体外膜小胞の生産とエイコサペンタエン酸生産能の欠損が膜小胞分泌におよぼす影響

  横山文秋; 今井友也; 川本 純; 小川拓哉; 栗原達夫

  第89回日本生化学会大会, 25 Sep. 2016

  
• Molecular Characterization of Eicosapentaenoic Acid-Containing Membrane Vesicles Produced by a Psychrotrophic Bacterium, Shewanella livistonensis Ac10

  Yokoyama Fumiaki; Jun Kawamoto; Tomoya Imai; Takuya Ogawa; Tatsuo Kurihara

  Extremophiles 2016 11th International Congress on Extremophiles, 12 Sep. 2016

  
• Substrate Specificity and Subcellular Localization of Multiple Lysophosphatidic Acid Acyltransferases from a Psychrotrophic Bacterium, Shewanella livingstonensis Ac10

  Toyotake Yosuke; Hyun-Nam Cho; Jun Kawamoto; Nobuyoshi Esaki; Tatsuo Kurihara

  Extremophiles 2016 11th International Congress on Extremophiles, 12 Sep. 2016

  
• Analysis of Protein Secretion System of a Membrane-vesicle Producing Cold-adapted Bacterium, Shewanella sp. HM13

  Chen Chen; Jun Kawamoto; Tomoya Imai; Tatsuo Kurihara

  Extremophiles 2016 11th International Congress on Extremophiles, 12 Sep. 2016

  
• Physiological function of polyunsaturated fatty acids in microbial cold- and high-pressure adaptation

  Jun Kawamoto; Tatsuo Kurihara

  5th International Workshop on Deep-Sea Microbiology, 10 Sep. 2016

  
• 真正細菌型1-アシルグリセロール-3-リン酸アシル基転移酵素PlsCの精製と酵素学的特性解析

  小川 拓哉; 田中麻子; 川本純; 栗原達夫

  第89回日本生化学会大会, Sep. 2016

  
• Purification and enzymatic characterization of bacterial 1-acyl-sn-glycerol-3-phosphate acyltransferase PlsC

  小川 拓哉; 田中麻子; 川本純; 栗原達夫

  The Fifth International Conference on Cofactors & Active Enzyme Molecule 2016, Sep. 2016

  
• 低温環境に生育する細菌の生存戦略

  川本 純; 栗原 達夫

  第９回リピッドカンファレンス, Sep. 2016

  
• Application of ω-Ethynyl Analog of Eicosapentaenoic Acid to Studies on Cold-Adaptation Mechanism of Shewanella livingstonensis Ac10

  Tokunaga, T; Watanabe, B; Kawamoto, J; Kurihara, T

  Extremophiles 2016, Kyoto, Japan, Sep. 2016

  
• EPA 産生細菌 Shewanella livingstonensis Ac10 における膜タンパク質の生産制御機構の解析

  杉浦美和; 浅井 梓; 水谷彩乃; 川本 純; 栗原達夫

  第33回日本微量栄養素学会, 25 Jun. 2016

  
• ω-エチニル型エイコサぺンタエン酸の機能評価と生理機能解析への応用

  徳永智久; 熊谷文仁; 渡辺文太; 川本純; 栗原達夫

  第58回日本脂質生化学会，秋田, 10 Jun. 2016

  
• エイコサペンタエン酸の生理機能解析に有用なプローブ分子の開発

  栗原達夫

  第444回ビタミンB研究協議会, 富山, Jun. 2016

  
• 低温菌 Shewanella livingstonensis Ac10 の菌体外膜小胞の特性とエイコサペンタエン酸が小胞形成に与える影響の解析

  横山文秋; 今井友也; 川本 純; 小川拓哉; 栗原達夫

  第63回 日本生化学会 近畿支部例会, 21 May 2016

  
• Characterization of a new cold-adapted Shewanella sp. to develop a system for secretory production of proteins.

  Chen Chen; Soichiro KAWAI; Jun Kawamoto; Tomoya Imai; Tatsuo kurihara

  日本農芸化学会 2016 年度大会, 30 Mar. 2016

  
• 低温適応性乳酸菌を宿主とした新規ベクターの構築

  二宮健匡; 後藤清太郎; 川本 純; 工藤和幸; 栗原達夫

  日本農芸化学会 2016 年度大会, 29 Mar. 2016

  
• Shewanella livingstonensis Ac10における多価不飽和脂肪酸プローブの機能評価

  徳永智久; 渡辺文太; 川本純; 栗原達夫

  日本農芸化学会2016年度大会，札幌, 28 Mar. 2016

  
• 低温菌 Shewanella livingstonensis Ac10 の菌体外膜小胞の解析

  横山 文秋; 川本 純; 今井 友也; 小川 拓哉; 栗原 達夫

  日本農芸化学会2016年度大会, Mar. 2016

  
• ω 末端修飾型多価不飽和脂肪酸プローブの開発と生理機能解析への応用

  徳永智久; 渡辺文太; 川本 純; 栗原達夫

  BMB2015, 02 Dec. 2015

  
• Visualization of subcellular localization of endogenous eicosapentaenoic acid in Shewanella livingstonensis Ac10 by using an anti-EPA monoclonal antibody

  CHO Hyun-Nam; 川本 純; 栗原達夫

  BMB2015, 02 Dec. 2015

  
• Mammalian Selenocysteine Lyase Is Involved in Selenoprotein Biosynthesis (vol 57, pg 298, 2011)

  Suguru Kurokawa; Masanori Takehashi; Hiromitsu Tanaka; Hisaaki Mihara; Tatsuo Kurihara; Seigo Tanaka; Kristina Hill; Raymond Burk; Nobuyoshi Esaki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Dec. 2015

  
• Screening of cold-adapted strains to develop the efficient protein-production and secretion system at low temperatures

  Chen Chen; Soichiro KAWAI; Jun Kawamoto; Tomoya Imai; Tatsuo kurihara

  第16回極限環境生物学会 2015年度年会, 08 Nov. 2015

  
• 生体膜マイクロドメインの形成を担うリン脂質生合成酵素の機能と局在性

  栗原達夫

  第41回日本応用酵素協会研究発表会, 大阪, Nov. 2015

  
• Shewanella livingstonensis Ac10におけるEPA含有リン脂質およびその生合成酵素の細胞内局在性

  栗原達夫

  第442回ビタミンB研究協議会, 京都, Oct. 2015

  
• ω-エチニル型エイコサペンタエン酸の開発と低温菌における生理機能解析への応用

  徳永智久; 渡辺文太; 川本 純; 栗原達夫

  リピッドカンファレンス, 16 Sep. 2015

  
• 低温菌 Shewanera livingstonensis Ac10 由来新規アシル鎖転移酵素 の基質特異性と細胞内局在性の解析

  豊竹洋佑; 川本 純; 栗原達夫

  リピッドカンファレンス, 16 Sep. 2015

  
• ω-エチニル型エイコサペンタエン酸の合成法の確立と EPA 生産性細菌における生理機能解析

  徳永智久; 渡辺文太; 川本 純; 栗原達夫

  特殊環境微生物セミナー2015, 08 Sep. 2015

  
• 低温菌 Shewanella livingstonensis Ac10 由来リゾリン脂質アシル基転移酵素が示す細胞内での基質特異性と局在性について

  豊竹洋佑; 川本 純; 栗原達夫

  特殊環境微生物セミナー2015, 08 Sep. 2015

  
• Distinct roles of 1-acylglycerol-3-phosphate O-acyltransferase isozymes in membrane phospholipid biogenesis in Shewanella livingstonensis Ac10

  T. Kurihara

  18th Japanese-German Workshop on Enzyme Technology, Sep. 2015, Invited

  
• Nar is the dominant dissimilatory nitrate reductase under high pressure conditions in the deep-sea denitrifier Pseudomonas sp. MT-1 (vol 61, pg 10, 2015)

  Yuji Oikawa; Yui Sinmura; Hikari Ishizaka; Ryota Midorikawa; Jun Kawamoto; Tatsuo Kurihara; Chiaki Kato; Koki Horikoshi; Hideyuki Tamegai

  JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Aug. 2015

  
• Subcellular localization of a key enzyme responsible for biosynthesis of EPA-containing phospholipids in an Antarctic bacterium

  CHO Hyun-Nam; 川本 純; 栗原達夫

  第57回脂質生化学会, 28 May 2015, Peer-reviewed

  
• 細菌の生体膜に見いだされたエイコサペンタエン酸含有マイクロドメイン-南極に住む微生物の生存戦略

  川本 純; 栗原達夫

  第57回脂質生化学会, 28 May 2015, Peer-reviewed, Invited

  
• Shewanella livingstonensis Ac10 における細胞膜リン脂質多様性に関与する PlsC4 の基質特異性の解析

  豊竹洋佑; 趙 賢南; 川本 純; 栗原達夫

  第62回 日本生化学会 近畿支部例会, 16 May 2015, Peer-reviewed

  
• エイコサペンタエン酸の新規生理機能解析に応用できる w- 末端修飾型脂肪酸アナログ体の効率的な合成法の確立

  徳永智久; 渡辺文太; 川本 純; 栗原達夫

  第62回 日本生化学会 近畿支部例会, 16 May 2015, Peer-reviewed

  
• 膜タンパク質の高次構造形成と翻訳後修飾における高度不飽和脂肪酸の機能解析

  栗原達夫

  長瀬科学技術振興財団研究成果発表会, 大阪, Apr. 2015

  
• 低温菌 Shewanella livinstonensis Ac10 における細胞分裂タンパク質の細胞内局在におけるエイコサペンタエン酸の役割

  岩野友里子; 川本 純; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• 低温適応性 Shewanella 属細菌におけるカルジオリピン生産性の解析

  浅井梓; 杉浦美和; 川本 純; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• 変敗食品より単離された低温適応性乳酸菌の固体表面への接着性の解析

  二宮健匡; 後藤清太郎; 川本 純; 工藤和幸; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• Shewanella livingstonensis Ac10 由来新規アシルトランスフェラーゼ PlsC4 は特定の分枝鎖飽和脂肪酸を細胞膜リン脂質に導入する

  豊竹洋佑; 趙 賢南; 川本 純; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• Eicosapentaenoic acid-containing membraene domain involved in cell divion of a cold-adapted bacterium

  KAWAMOTO Jun; KURIHARA Tatsuo

  Biophysical Society 2015, 28 Mar. 2015, Peer-reviewed

  
• 低温適応細菌 Shewanella livingstonensis Ac10 の外膜タンパク質の構造形成解析

  杉浦美和; 浅井 梓; 水谷彩乃; 川本 純; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 のエイコサペンタエン酸生合成酵素の細胞分裂部位への局在性と複合体形成の解析

  小倉隆太郎; 趙 賢南; 川本 純; 栗原達夫

  日本農芸化学会 2015 年度大会, 28 Mar. 2015, Peer-reviewed

  
• ω末端修飾型高度不飽和脂肪酸アナログの合成

  徳永智久; 渡辺文太; 川本純; 栗原達夫

  日本農芸化学会2014年度大会，岡山, 28 Mar. 2015

  
• Shewanella livingstonensis Ac10 におけるリン脂質への飽和脂肪酸導入を担うアシルトランスフェラーゼ

  栗原達夫

  第439回ビタミンB研究協議会, 東京, Feb. 2015

  
• 低温菌 Shewanella livingstonensis Ac10 の金属呼吸に関与する外膜輸送タンハ_ク質の解析

  丸山沙織; 川本 純; 栗原達夫

  第１５回極限環境生物学会, 02 Nov. 2014, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 の飽和脂肪酸含有リン脂質生合成に関与する新規アシルトランスフェラーゼの解析

  豊竹洋佑; 趙 賢南; 川本 純; 栗原達夫

  第 87 回日本生化学会大会, 02 Nov. 2014, Peer-reviewed

  
• Membrane microdomain enriched in eicosapentaenoic acid-containing phospholipids in Shewanella livingstonensis Ac10

  T. Kurihara

  Japan-Italy Joint Symposium, Nov. 2014, Invited

  
• 細菌におけるエイコサペンタエン酸含有リン脂質生合成酵素群の細胞内局在性と機能

  栗原達夫

  第438回ビタミンB研究協議会, 大阪, Nov. 2014

  
• 高度不飽和脂肪酸を含む細菌細胞膜マイクロドメインの形成に関与する酵素群の局在性

  栗原達夫

  第40回日本応用酵素協会研究発表会, 大阪, Nov. 2014

  
• 低温菌 Shewanella livingstonensis Ac10 の細胞分裂サイトへのエイコサペンタエン酸生合成酵素の局在

  小倉隆太郎; 川本 純; 栗原達夫

  第 87 回日本生化学会大会, 18 Oct. 2014, Peer-reviewed

  
• The role of the N-terminal domain of 1-acyl-sn-glycerol-3-phosphate acyltransferase of Shewanella livingstonensis Ac10 in its subcellular localization

  趙 賢南; 川本 純; 栗原達夫

  第 87 回日本生化学会大会, 18 Oct. 2014, Peer-reviewed

  
• クリックケミストリーによる血管内皮細胞における不飽和脂肪酸修飾タンパク質の同定

  川本 純; 山浦貴之; 佐藤 智; 栗原達夫

  第 87 回日本生化学会大会, 18 Oct. 2014, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 のリン脂質生合成に関与する 新規アシルトランスフェラーセ_の基質特異性の解析

  豊竹洋佑; 趙賢南; 川本 純; 栗原達夫

  特殊環境微生物セミナー2014, 18 Oct. 2014, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 におけるエイコサペンタエン酸含有マイクロドメインの形成

  川本 純; 趙賢南; 小倉隆太郎; 岩野友里子; 栗原達夫

  特殊環境微生物セミナー2014, 01 Oct. 2014, Peer-reviewed

  
• 細菌のエイコサペンタエン酸含有リン脂質生合成を担うアシル鎖転移酵素の機能解析

  CHO Hyun-Nam; KAWAMOTO Jun; KURIHARA Tatsuo

  リピッド合同カンファレンス, 18 Sep. 2014, Peer-reviewed

  
• Subcellular localization of 1-acyl-sn-glycerol-3-phosphate acyltransferase responsible for synthesis of EPA-containing phospholipids, is required for cell division of Shewanella livingstonensis Ac10

  CHO Hyun-Nam; KAWAMOTO Jun; KURIHARA Tatsuo

  第 61回日本生化学会近畿支部例会, 17 May 2014, Peer-reviewed

  
• Physiological functions of a polyunsaturated fatty acid, eicosapentaenoic acid

  栗原 達夫; 川本 純

  医学のあゆみ, 29 Mar. 2014

  
• ω-エチニル型脂肪酸を用いた血管内皮細胞における不飽和脂肪酸修飾タンパク質の同定法開発

  山浦貴之; 佐藤 智; 川本 純; 栗原達夫

  日本農芸化学会 2014 年度大会, 29 Mar. 2014, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 の低温誘導性外膜タンパク質の機能解析

  浅井梓; 川本 純; 栗原達夫

  日本農芸化学会 2014 年度大会, 29 Mar. 2014, Peer-reviewed

  
• エイコサペンタエン酸による低温菌 Shewanella livingstonensis Ac10 の細胞分裂タンパク質の制御

  岩野友里子; 川本 純; 栗原達夫

  日本農芸化学会 2014 年度大会, 29 Mar. 2014, Peer-reviewed

  
• ω-エチニル型エイコサペンタエン酸の合成法の確立

  徳永智久; 渡辺文太; 川本純; 栗原達夫

  日本農芸化学会2014年度大会，東京, 29 Mar. 2014

  
• Eicosapentaenoic Acid-containing Phospholipids Change the Conformation of an Outer Membrane Protein from an Antarctic Cold-adapted Bacterium, Shewanella livingstonensis Ac10

  Sugiura, M; KAWAMOTO Jun; KURIHARA Tatsuo

  ICRIS 2014, 10 Mar. 2014, Peer-reviewed

  
• Subcellular localization and physiological function of 1-acyl-sn-glycerol-3-phosphate acyltransferase of an EPA-producing bacterium, Shewanella livingstonensis Ac10

  CHO Hyun-Nam; KAWAMOTO Jun; KURIHARA Tatsuo

  ICRIS 2014, 10 Mar. 2014, Peer-reviewed

  
• エイコサペンタエン酸含有リン脂質の生合成を担う細菌アシルトランスフェラーゼ PlsC

  栗原達夫

  第435回ビタミンB研究協議会, 大阪, Feb. 2014

  
• Selenocysteine lyase: Delivering selenium in biosynthetic pathway

  H. Mihara; T. Kurihara; N. Esaki

  Selenium in the Environment and Human Health - Proceedings of the 3rd International Conference on Selenium in the Environment and Human Health, 2014, Peer-reviewed

  
• 低温菌の環境適応を担う細胞膜脂質

  栗原達夫; 川本純

  第29回日本微生物生態学会大会, 25 Nov. 2013, Peer-reviewed

  
• Roles of eicosapentaenoic acid-containing phospholipids in bacterial cell membrane

  KURIHARA Tatsuo

  EMBO|EMBL Symposium New Approaches and Concepts in Microbiology, Oct. 2013, Peer-reviewed

  
• 細菌の細胞分裂と膜タンパク質生合成における高度不飽和脂肪酸含有リン脂質の機能

  栗原達夫; 川本純

  第86回日本生化学会大会, 13 Sep. 2013, Peer-reviewed

  
• 極地由来好冷性微生物を宿主とした新しいタンパク質低温生産システムの開発

  栗原達夫

  Inst Ferment Osaka Res Commun, 25 Dec. 2012

  
• Shewanella livingstonensis Ac10 におけるエイコサペンタエン酸の機能

  栗原達夫

  特殊環境微生物セミナー, 横浜, 22 Nov. 2012

  
• 細菌における高度不飽和脂肪酸含有リン脂質の生合成と機能

  栗原達夫

  第38回日本応用酵素協会研究発表会, 大阪, 19 Nov. 2012

  
• 細菌細胞膜における高度不飽和脂肪酸含有リン脂質の局在性

  栗原達夫

  第430回ビタミンB研究協議会, 京都, 17 Nov. 2012

  
• 希少金属資源回収と有害金属除去に資する微生物の開発

  栗原 達夫; 川本 純; Takefumi Hattori

  平成22-23年度研究成果報告書，京都大学生存基盤科学研究ユニット, Mar. 2012

  
• 細菌における高度不飽和脂肪酸の生理機能

  栗原達夫

  第427回ビタミンB研究協議会, 京都, 04 Feb. 2012

  
• 高度不飽和脂肪酸生産菌Shewanella livingstonnensis Ac10の1-acyl-sn-glycerol-3-phosphate acyltransferase (PlsC)、機能解析

  趙 賢南; 笠井 渉; 川本 純; 栗原 達夫; 江崎 信芳

  日本生化学会第82回大会 ,京都, 23 Sep. 2011, Peer-reviewed

  
• Carboxyl Terminal Amino Acid Residues Involved in the Stability of an Outer Membrane Protein from a Psychrotrophic Bacterium

  代 先祝; 川本 純; 佐藤 智; 栗原 達夫; 江崎 信芳

  日本生化学会第82回大会 ,京都, 23 Sep. 2011, Peer-reviewed

  
• A flavoenzyme from Burkholderia sp. WS that is involved in metabolism of 2-chloroacrylic acid

  Anoop Vasudevan; 藤田倫代; 倉田淳志; 川本純; 栗原達夫; 江崎信芳

  日本生化学会第82回大会 ,京都, 23 Sep. 2011, Peer-reviewed

  
• Characterization of the eicosapentaenoic acid biosynthesis proteins from Shewanella livingstonensis Ac10

  宮 春傑; 川本 純; 栗原 達夫; 江崎 信芳; 川本 純; 栗原 達夫; 江崎 信芳

  日本生化学会第82回大会 ,京都, 23 Sep. 2011, Peer-reviewed

  
• 外膜ポーリンタンパク質の構造形成における高度不飽和脂肪酸含有リン脂質の機能

  川本 純; 代 先祝; 佐藤 智; 栗原達夫

  日本生化学会近畿支部例会 ,大阪, 21 May 2011, Peer-reviewed

  
• 高度不飽和脂肪酸含有リン脂質の生合成と機能

  栗原達夫; 川本純; 江崎信芳

  日本農芸化学会大会講演要旨集, 05 Mar. 2011, Peer-reviewed

  
• 架橋性リン脂質プローブを用いたEPA含有リン脂質標的タンパク質の探索

  佐藤翔; 栗原達夫; 中瀬生彦; 東佑翼; 二木史郎; 渡辺文太; 平竹潤; 友廣岳則; 畑中保丸; 川本純; 江崎信芳

  日本農芸化学会2011年度大会，京都, Mar. 2011

  
• FADH2依存性水付加酵素2-ハロアクリル酸ヒドラターゼの反応機構解析

  栗原達夫

  第422回ビタミンB研究協議会, 京都, 27 Nov. 2010

  
• 好圧性および非好圧性 Shewanella 属細菌の高圧下における呼吸鎖末端酸化酵素活性

  為我井 秀行; 太田裕也; 羽賀みなみ; 藤森裕基; 加藤千明; 能木裕一; 川本純; 栗原達夫; 三本木至

  極限環境生物学会第11回大会 ,京都, 16 Nov. 2010, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 の 低温誘導性外膜タンパク質の膜挿入と フォールディングにおけるエイコサペンタエン酸の役割

  代 先祝; 川本 純; 佐藤 智; 栗原 達夫; 江崎 信芳

  極限環境生物学会第11回大会 ,京都, 15 Nov. 2010, Peer-reviewed

  
• 蛍光標識エーテル型リン脂質を用いた EPA 含有リン脂質のダイナミクス解析

  佐藤翔; 栗原 達夫; 佐藤 智; 川本 純; 江崎 信芳

  極限環境生物学会第11回大会 ,京都, 15 Nov. 2010, Peer-reviewed

  
• Construction of protein expression system by using cold-adapted bacteria as the host

  Kurihara, T

  MicroPerm Workshop, Potsdam, Germany, 08 Nov. 2010, Peer-reviewed

  
• 2-クロロアクリル酸の酵素的分解機構の解析

  栗原達夫

  第62回日本生物工学会大会, 宮崎, 29 Oct. 2010

  
• ポーリンタンパク質のフォールディングにおける高度不飽和脂肪酸含有リン脂質の生理機能

  川本 純; 代 先祝; 栗原達夫; 佐藤 智; 江崎信芳

  日本生物工学会 ,宮崎, 28 Oct. 2010, Peer-reviewed

  
• 耐冷性乳酸菌の低温適応機構の解析

  後藤 清太郎; 川本 純; 栗原 達夫; 壱岐 隆; 渡辺 至; 江崎 信芳

  日本生物工学会 ,宮崎, 28 Oct. 2010, Peer-reviewed

  
• FADH₂依存的な水付加反応を触媒する2-ハロアクリル酸ヒドラターゼの特性

  栗原達夫

  酵素・補酵素研究会, 北九州, 10 Sep. 2010

  
• 低温菌 Shewanella livingstonensis Ac10 の低温誘導性膜タンパク質の網羅的解析

  朴 貞河; 川本 純; 栗原 達夫; 江崎 信芳

  特殊環境微生物セミナー ,京都, 16 Jul. 2010, Peer-reviewed

  
• 合成分子プローブを用いた EPA 含有リン脂質の動的挙動の解析

  佐藤翔; 栗原 達夫; 佐藤 智; 川本 純; 江崎 信芳

  特殊環境微生物セミナー ,京都, 16 Jul. 2010, Peer-reviewed

  
• Exploring of novel physiological roles of PUFA-containing phospholipids with a cold-adapted bacterium.

  Jun KAWAMOTO; Tatsuo KURIHARA; Nobuyoshi ESAKI

  The 27th Naito Conference Membrane Dynamics and Lipid Biology [I] ,札幌, 29 Jun. 2010, Peer-reviewed

  
• エイコサペンタエン酸含有リン脂質の動態解析に用いる分子プローブの合成

  佐藤 翔; 栗原 達夫; 川本 純; 江崎 信芳

  日本農芸化学会 ,東京, 30 Mar. 2010, Peer-reviewed

  
• 耐冷性乳酸菌の低温増殖性に関わるタンパク質の探索

  後藤 清太郎; 川本 純; 栗原 達夫; 壱岐 隆; 渡辺 至; 江崎 信芳

  日本農芸化学会 ,東京, 29 Mar. 2010, Peer-reviewed

  
• Physiological role of eicosapentaenoic acid-containing phospholipids in the folding of a cold-inducible outer membrane protein

  DAI Xian-Zhu; KAWAMOTO Jun; SATO Satoshi; KURIHARA Tatsuo; ESAKI Nobuyoshi

  日本農芸化学会 ,東京, 29 Mar. 2010, Peer-reviewed

  
• 2P-1155 Analysis of the cold-adaptation mechanism of cold-tolerant lactic acid bacteria

  GOTO Seitaro; KAWAMOTO Jun; KURIHARA Tatsuo; IKI Takashi; WATANABE Itaru; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2010

  
• 2-クロロアクリル酸への水付加反応を触媒する新規 FAD 酵素

  栗原達夫

  第418回ビタミンB研究協議会, 京都, 28 Nov. 2009

  
• 低温誘導性ポーリンのフォールディングにおけるエイコサペンタエン酸含有リン脂質の生理的役割

  川本 純; 代 先祝; 佐藤智; 栗原達夫; 江崎信芳

  極限環境日生物学会第10回大会 ,東京, 28 Oct. 2009, Peer-reviewed

  
• Pseudomonas sp. Ak26 におけるヘモリシン共制御タンパク質ホモログ分泌機構の解析

  桃川雄介; 小山 大; 川本 純; 栗原 達夫; 江崎 信芳

  日本生化学会第82回大会 ,神戸, 23 Oct. 2009, Peer-reviewed

  
• エイコサペンタエン酸含有エーテル型リン脂質の合成

  佐藤翔; 栗原達夫; 岡崎雅明; 川本 純; 小澤文幸; 江崎信芳

  日本生化学会第82回大会 ,神戸, 22 Oct. 2009, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10におけるリン脂質 de novo 合成経路の解析

  笠井渉; 川本 純; 栗原 達夫; 江崎 信芳

  日本生化学会第82回大会 ,神戸, 22 Oct. 2009, Peer-reviewed

  
• 有機ハロゲン化合物代謝関連酵素の開発と応用

  栗原達夫

  第５回 広島大学・海洋科学技術センター・近畿大学 合同セミナー , 東広島, 09 Oct. 2009

  
• Cold-adaptation mechanism of an Antarctic psychrotrophic bacterium, Shewanella livingstonensis Ac10

  Kurihara, T

  Xth SCAR International Biology Symposium, 札幌, 27 Aug. 2009, Peer-reviewed

  
• Eicosapentaenoic acid plays an important role in assembly of cell division machinery of an Antarctic sea bacterium, Shewanella livingstonensis Ac10

  川本 純; 栗原 達夫; 江崎 信芳

  SCAR international symposium ,札幌, 26 Jul. 2009, Peer-reviewed

  
• 炭素-炭素二重結合への水付加反応を触媒する新規フラビン酵素

  栗原達夫

  第61回日本ビタミン学会大会, 亀岡, 31 May 2009

  
• エイシリカコロイドを用いたグラム陰性細菌 Shewanella livingstonensis Ac10 の膜分離

  朴 貞河; 川本 純; 池ノ内 順一; 栗原 達夫; 江崎 信芳

  日本農芸化学会 ,福岡, 29 Mar. 2009, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 のエイコサペンタエン酸と細胞分裂装置との関連について

  川本 純; 栗原 達夫; 三原 久明; 江崎 信芳

  日本農芸化学会 ,福岡, 29 Mar. 2009, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 のエイコサペンタエン酸生合成調節に関わる遺伝子 orf4 及び orfR の機能解析

  古賀 敬太郎; 川本 純; 栗原 達夫; 江崎 信芳

  日本農芸化学会 ,福岡, 29 Mar. 2009, Peer-reviewed

  
• 2-クロロアクリル酸への水付加による脱ハロゲン反応を触媒する新奇フラビン酵素

  栗原達夫

  日本農芸化学会大会, 福岡, 29 Mar. 2009

  
• 3S8a01 Discovery of novel enzymes catalyzing conversion of organohalogen compounds and their application

  KURIHARA Tatsuo; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2009

  
• Functions of phospholipids containing polyunsaturated fatty acids in cold-adapted bacteria

  T. Kurihara

  Seikagaku, 2009

  
• 2Fp15 Metabolism of 2-chloroacrylate in Burkholderia sp. WS

  KURIHARA Tatsuo; FUJITA Michiyo; MOWAFY Amr M.; KURATA Aatsushi; ESAKI Nobuyoshi

  第60回日本生物工学会大会, 東北学院大学土樋キャンパス, 28 Aug. 2008

  
• 海洋性低温菌 Shewanella livingstonensis Ac10 における高度不飽和脂肪酸の機能

  栗原達夫

  第11回マリンバイオテクノロジー学会大会, 京都大学吉田キャンパス, 25 May 2008

  
• OII-11 哺乳類Selenocysteine Lyaseの組織における生理的機能解析(男性生殖器,一般口演,「出島」游學-形態通詞の未来展開-,第49回日本組織細胞化学会総会・学術集会)

  黒川 優; 竹橋 正則; オルソン ゲイリー; ウィンフレイ バージニア; ヒル クリスティーナ; バーク レイモンド; 田中 静吾; 栗原 達夫; 江崎 信芳

  日本組織細胞化学会総会プログラムおよび抄録集, 2008

  
• Investigation of the roles of cysteine desulfurases in the molybdopterin synthesis in Escherichia coli

  Zhang Wanjiao; Mihara Hisaaki; Kurihara Tatsuo

  Proceedings Symposium on Trace Nutrients Research, 2008

  
• Enzyme useful for asymmetric synthesis of N-alkyl amino acids and cyclic imino acids

  村松 久司; 三原 久明; 栗原 達夫; 江﨑 信芳

  Fine chemicals, 2008

  
• Physiological role of phospholipids containing eicosapentaenoic acid in cold adaptation of an Antarctic psychrotrophic bacterium, Shewanella livingstonensis Ac10

  Kurihara, T

  Gordon Research Conferences (Lipids, Molecular & Cellular Biology Of), Waterville Valley, NH, USA, 24 Jul. 2007, Peer-reviewed

  
• 哺乳類細胞におけるセレンタンパク質生合成に関わる因子の同定と解析

  横山いずみ; 畑千嘉子; 黒川優; 三原久明; 嶋田崇史; 池川雅哉; 川本純; 栗原達夫; 江崎信芳

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• 3I10-1 Modulation of outer membrane permeability of a psychrotrophic bacterium, Shewanella livingstonensis Ac10

  KAWAMOTO Jun; KURIHARA Tatsuo; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2007

  
• Cold-adaptation Mechanism of a Psychrotrophic Bacterium, Shewanella livingstonensis Ac10, and Its Applications

  Kurihara, T

  Extremophiles 2006, Brest, France, 20 Sep. 2006, Peer-reviewed

  
• 低温菌 Shewanella livingstonensis Ac10 の低温適応に関与するタンパク質の同定と機能解析

  栗原達夫

  第6回日本蛋白質科学会年会, 京都, 24 Apr. 2006

  
• 低温でタンパク質をつくる新技術 : 低温菌を宿主とした次世代タンパク質生産システムの開発

  栗原 達夫; 江崎 信芳

  化学と生物, 01 Jan. 2006

  
• 2H09-1 Identification of Genes Involved in Cold-Adaptation of a Psychrotrophic Racterium,Shewanella livingstonensis Ac 10, by Transposon Mutagenesis

  INOMOTO Yasushi; KURISU Takayuki; MIYAKE Ryoma; KURIHARA Tatsuo; KITAGAWA Masanari; KATO Ikunoshin; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2006

  
• 2H09-3 Functional analysis of two FtsZ proteins involved in the morphological changes of a psychrotrophic bacterium, Shewanella livingstonensis Ac 10, depending on cultivation temperatures

  KAWAMOTO Jun; GOTO Syuichi; MIYAKE Ryoma; KURIHARA Tatsuo; KITAGAWA Masanari; KATO Ikunoshin; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2006

  
• 2H09-2 Identification of a cold-inducible gene of Shewanella livingstonensis Ac 10 by using a promoter-probe vector and analysis of its role in cold adaptation

  MIYAKE Ryoma; KURIHARA Tatsuo; KITAGAWA Masanari; KATO Ikunoshin; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2006

  
• 哺乳類におけるセレノシステイン挿入配列結合因子の同定と解析

  横山いずみ; 畑千嘉子; 黒川優; 三原久明; 池川雅哉; 嶋田崇史; 栗原達夫; 江崎信芳

  日本農芸化学会関西支部講演会講演要旨集, 2006

  
• 2-III-27 シュードモナスのリジン分解経路におけるミッシング酵素の同定と解析(一般研究発表,日本ビタミン学会 第58回大会研究発表要旨)

  三原 久明; 大崎 元晴; 桧作 好之; 山西 芳裕; 五斗 進; 金久 實; 栗原 達夫; 江崎 信芳

  ビタミン, 2006

  
• 低温菌Shewanella sp. Ac10におけるエイコサペンタエン酸の生合成調節と機能

  栗原達夫

  日本Archaea研究会第18回講演会・極限環境微生物学会第6回シンポジウム合同大会, 京都大学桂キャンパス, 16 Jul. 2005

  
• 2-B-12 光学活性なN-アルキルアミノ酸および環状イミノ酸の合成に有用な酵素(第57回大会一般研究発表)(第57回大会研究発表要旨)

  三原 久明; 村松 久司; 角谷 亮; 安田 磨理; 上田 誠; 栗原 達夫; 江崎 信芳

  ビタミン, 25 Apr. 2005

  
• ゲノム情報に基づいたリジン分解系タンパク質ネットワークの再構築

  大崎元晴; 村松久司; 山西芳裕; 桧作好之; 三原久明; 五斗進; 金久実; 栗原達夫; 江崎信芳

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• The 77^ Annual Meeting of the Japanese Biochemical Society

  ANO Yoshitaka; SAKAI Yasuyoshi; YOKOI Yuka; SATO Ryuichiro; KURIHARA Tatsuo

  Bioscience & industry, 01 Jan. 2005

  
• 1A13-3 Expression of heterologous proteins from a psychrophile by using a psychrotroph as the host.

  MIYAKE Ryoma; KAWAMOTO Jun; KURIHARA Tatsuo; KITAGAWA Masanari; KATO Ikunoshin; ESAKI Nobuyoshi

  日本生物工学会大会講演要旨集, 2005

  
• 有機ハロゲン化合物の酵素的分解機構 (環境をめぐる視点(2))

  栗原 達夫; 江崎 信芳

  環境保全, 2004

  
• Construction of Protein Overproduction System Using a Coldadapted Microorganism as a Host

  Kurihara Tatsuo; Wei Yun lin; Hayashi Misa; Esaki Nobuyoshi

  日本生物工学会大会, 熊本大学, 16 Sep. 2003

  
• 2-クロロアクリル酸不斉還元酵素の構造と機能

  栗原達夫

  日本生化学会近畿支部例会, 大阪, 31 May 2003

  
• Enhanced selenium tolerance and accumulation in transgenic arabidopsis expressing a mouse selenocysteine lyase. (vol 131, pg 1250, 2003)

  M Pilon; JD Owen; GF Garifullina; T Kurihara; H Mihara; N Esaki; EAH Pilon-Smits

  PLANT PHYSIOLOGY, May 2003

  
• マウスのセレノシステインリアーゼによる植物のセレン耐性増強

  栗原達夫

  日本農芸化学会大会, 藤沢, 01 Apr. 2003

  
• Characterization of a NifS-like chloroplast protein from Arabidopsis. Implications for its role in sulfur and selenium metabolism (vol 130, pg 1309, 2002)

  EAH Pilon-Smits; GF Garifullina; S Abdel-Ghany; SI Kato; H Mihara; KL Hale; JL Burkhead; N Esaki; T Kurihara; M Pilon

  PLANT PHYSIOLOGY, Jan. 2003

  
• 606 Identification of novel enzymes catalyzing asymmetric reduction of 2-chloroacrylic acid

  Kurihara Tatsuo; Kurata Atsushi; Kamachi Harumi; Esaki Nobuyoshi

  日本生物工学会大会, 大阪, 28 Oct. 2002

  
• 炭素炭素二重結合の不斉還元を触媒する新規酵素の開発

  栗原達夫

  日本農芸化学会関西支部大会, 奈良, 06 Oct. 2002

  
• The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H

  Hisaaki Mihara; Shin Ichiro Kato; Gerard M. Lacourciere; Thressa C. Stadtman; Robert A.J.D. Kennedy; Tatsuo Kurihara; Umechiyo Tokumoto; Yasuhiro Takahashi; Nobuyoshi Esaki

  Proceedings of the National Academy of Sciences of the United States of America, 14 May 2002, Peer-reviewed

  
• Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: Implications for the mechanism of iron-sulfur cluster assembly

  Shin Ichiro Kato; Hisaaki Mihara; Tatsuo Kurihara; Yasuhiro Takahashi; Umechiyo Tokumoto; Tohru Yoshimura; Nobuyoshi Esaki

  Proceedings of the National Academy of Sciences of the United States of America, Apr. 2002, Peer-reviewed

  
• Probing Active-site Environment of Fluoroacetate Dehalogenase by Catalisis-Linked Inactiveation with Ammonia / Functional characterization of Alanine racemase from Schizosaccharomyces pombe (MOLECULAR BIOFUNCTION - Molecular Microbial Science)

  ESAKI Nobuyoshi; YOSHIMURA Tohru; KURIHARA Tatsuo; MIHARA Hisaaki

  ICR annual report, Mar. 2002

  
• How Do Dehalogenases Cleave Carbon-Halogen Bonds ? An Approach by Mass Spectrometry.

  Kurihara, T

  International Winter School on Bioorganic Chemistry, Hirschegg, Austria, 20 Feb. 2002

  
• 低温菌 Acinetobacter sp. DWC6 を用いた脂質変換系の開発

  栗原達夫

  日本生物工学会大会, 甲府, 28 Sep. 2001

  
• 質量分析法による２ハロ酸デハロゲナーゼの反応機構解析

  栗原達夫

  蛋白質科学会年会, 大阪, 03 Jun. 2001

  
• 質量分析法による酵素触媒機構の研究

  栗原 達夫; 江崎 信芳

  日本農芸化学会誌, 05 Mar. 2001

  
• Novel Mechanism of Enzymatic Hydrolysis Involving Cyanoalanine Intermediate Revealed by Mass Spectrometric Monitoring of an Enzyme Reaction (MOLECULAR BIOFUNCTION-Molecular Microbial Science)

  Esaki Nobuyoshi; Kurihara Tatsuo; Li Yong-Fu; Ichiyama Susumu

  ICR annual report, Mar. 2001

  
• Bioconversion of lipids at low temperatures by psychrotrophic Acinetobacter sp. strain No.6

  Kurihara Tatsuo; Suzuki Takeshi; Wei Yun-lin; Esaki Nobuyoshi

  日本生物工学会大会講演要旨集, 2001

  
• Enzymatic Discrimination between Selenium and Sulfur: Mechanistic and Structural Difference between Selenocysteine Lyase and Cysteine Desulfurase

  Kurihara, T

  7th International Symposium on Selenium in Biology and Medicine, Venezia, Italy, 01 Oct. 2000, Peer-reviewed

  
• Mechanisms of Enzymatic Hydrolysis of Organohalogen Compounds

  Kurihara, T

  Fifth International Symposium on Environmental Biotechnology, 京都, 12 Jul. 2000, Peer-reviewed

  
• 1-II-4 大腸菌新奇NifSホモログ、CSDの触媒特性

  江崎 信芳; 三原 久明; 栗原 達夫; 吉村 徹; 左右田 健次

  ビタミン, 25 Apr. 2000

  
• Reaction Mechanism of DL-2-Haloacid Dehalogenase from Pseudomonas sp. 113: Hydrolytic Dehalogenation Not Involving Enzyme-Substrate Ester Intermediate (MOLECULAR BIOFUNCTION-Molecular Microbial Science)

  Esaki Nobuyoshi; Kurihara Tatsuo; Soda Kenji; Nardi-Dei Vincenzo; Park Chung

  ICR annual report, Mar. 2000

  
• Role of the Conserved Cysteine Residue of Three NifS Homologs from Escherichia coli Functioning as Cysteine Desulfurase and Selenocysteine Lyase

  Kurihara, T

  10th International Symposium on Vitamin B6 & Carbonyl Catalysis, Santa Fe, New Mexico, USA, 03 Nov. 1999, Peer-reviewed

  
• 質量分析法を利用したハロ酸デハロゲナーゼ反応機構の解析

  栗原達夫

  日本農芸化学会中部支部・関西支部合同大会, 岐阜, 02 Oct. 1999

  
• Role of lysine 39 of alanine racemase for Bacillus stearothermophilus that binds pyridoxal 5 '-phosphate. Chemical rescue studies of Lys(39) -> Ala mutant. (vol 274, pg 4189, 1999)

  A Watanabe; Y Kurokawa; T Yoshimura; T Kurihara; K Soda; N Esaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1999

  
• 小胞体からの COPII 小胞出芽における Sec24p ホモログ Lst1p の機能：細胞膜局在性 ATPase (Pma1p) の小胞への取り込み

  栗原達夫

  日本農芸化学会大会, 福岡, 01 Apr. 1999

  
• 3. ビタミンB_6酵素, システインデスルフラーゼの構造と機能

  江崎 信芳; 三原 久明; 栗原 達夫; 吉村 徹; 左右田 健次

  ビタミン, 25 Jun. 1998

  
• Cysteine Sulfinate Desulfinase, a NIFS-like Protein of Escherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities: Gene Cloning, Purification and Characterization of a Novel Pyridoxal Enzyme

  Esaki Nobuyoshi; Kurihara Tatsuo; Yoshimura Tohru; Soda Kenji; Mihara Hisaaki

  ICR annual report, Mar. 1998

  
• Pseudomonas sp. YLのL-2-ハロ酸デハロゲナーゼの触媒反応機構

  西原 光洋; 劉 吉泉; 栗原 達夫; 宮城 大; 綱澤 進; 畑 安雄; 江崎 信芳; 左右田 健次

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• アラスカ産Pseudomonas属低温菌が生産するリパーゼの構造と性質

  秋 東圓; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Escherichia coli JM109のシステインデスルフラーゼの発現系の構築と諸性質

  三原 久明; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本分子生物学会年会プログラム・講演要旨集, Aug. 1996

  
• Pseudomonas sp. 113のDL-2- : ハロ酸デハロゲナーゼの反応機構 : タンパク質工学

  朴 清; Nardi-Dei Vincenzo; 栗原 達夫; 宮城 大; 綱澤 進; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Mar. 1996

  
• Reaction machanism of L-2-haloacid dehalogenase from Pseudomonas sp. YL

  西原 光洋; 劉吉 泉; 栗原 達夫; 宮城 大; 綱澤 進; 畑 安雄; 江崎 信芳; 左右田 健次

  Journal of the Agricultural Chemical Society of Japan, 05 Mar. 1996

  
• フルオロ酢酸デハロゲナーゼの触媒反応におけるHis272の機能 : タンパク質工学

  栗原 達夫; 劉 吉泉; 市山 進; 宮城 大; 綱澤 進; 川崎 東彦; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Mar. 1996

  
• フルオロ酢酸デハロゲナーゼの触媒反応におけるAsp105の機能 : タンパク質工学

  劉 吉泉; 市山 進; 栗原 達夫; 宮城 大; 綱澤 進; 川崎 東彦; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Mar. 1996

  
• Acinetobacter属低温菌が生産するリパーゼの反応特性 : 酵素

  鈴木 剛司; 秋 東圓; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Mar. 1996

  
• Pseudomonas属低温菌が生産するリパーゼの一次構造 : 酵素

  秋 東圓; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Mar. 1996

  
• Identification of Asp 10 as the Active Site Nucleophile of L-2-Haloacid Dehalogenase of Pseudomonas sp. YL (BIOFUNCTIONAL MOLECULES - Molecular Microbial Science)

  Soda Kenji; Esaki Nobuyoshi; Kurihara Tatsuo; Liu Ji-Quan

  ICR annual report, Mar. 1996

  
• CRYSTAL STRUCTURE OF L-2-HALOACID DEHALOGENASE FROM Pseudomonas sp YL AT 2.5 angstrom RESOLUTION

  Y. Hata; T. Hisano; T. Fujii; J. -Q. Liu; T. Kurihara; N. Esaki; K. Soda

  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996

  
• Neurospora crassaの2-ニトロプロパンジオキシゲナーゼの精製と諸性質の検討 : 酵素,食品

  Gorlatova Natalia; Tchorzewski Marck; 栗原 達夫; 江崎 信芳; 杉山 卓; 浅田 浩二; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• 好熱菌Bacillus steorothemophilusのアラニンラセマーゼにおける活性中心リジン残基の役割 : 酵素

  黒川 洋一; 吉村 徹; 外山 博英; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• L-2-ハロ酸デハロゲナーゼの分解能2.5Åの結晶構造 : タンパク質工学

  久野 玉雄; 畑 安雄; 藤井 知実; 栗原 達夫; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• 部位特異的変異実験によるL-2-ハロ酸デハロゲナーゼの機能性アミノ酸残基の探索 : タンパク質工学

  栗原 達夫; 劉 吉泉; Nardi-Dei Vincenzo; 越川 博元; 畑 安雄; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• ^<18>O取り込み実験によるL-2-ハロ酸デハロゲナーゼの反応機樽の解析 : タンパク質工学

  江崎 信芳; 劉 吉泉; 栗原 達夫; 宮城 大; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• L-2-ハロ酸デハロゲナーゼの活性中心Asp10のヒドロキシルアミンによる修飾 : タンパク質工学

  劉 吉泉; 栗原 達夫; 宮城 大; 江崎 信芳; 左右田 健次

  日本農藝化學會誌, 05 Jul. 1995

  
• 1-III-13 酵母Hansenula mrakiiが生産するFAD酵素2-ニトロプロパンジオキシゲナーゼの遺伝子構造解析 : 第46回大会研究発表要旨

  江崎 信芳; M. Tchorzewski; 栗原 達夫; 左右田 健次

  ビタミン, 25 Apr. 1994

  
• Chemical modification of haloacetate dehalogenase from Moraxella sp. strain B

  Koshikawa Hiromoto; Liu Ji-Quan; Nardi-Dei V.; Kurihara Tatsuo; Esaki Nobuyoshi; Soda Kenji

  日本生物工学会大会講演要旨集, 1993

  
• Screening of Bacterial Lipases with High Activity at Low Temperature, and Their Enzymatic Properties

  Kamei Masugu; Esaki Nobuyoshi; Kurihara Tatsuo; Katsura Shin-ichi; Soda Kenji

  日本生物工学会大会講演要旨集, 1992

  
• 低温菌 Shewanella livingstonensis Ac10 における EPA 生合成酵素の局在性と相互作用解析

  小倉隆太郎; 川本 純; 栗原達夫

  第１５回極限環境生物学会, Peer-reviewed

  

Presentations

• Shewanella vesiculosa HM13 の細胞外膜小胞生産関連遺伝子の生理機能解析

  井上 宙夢; 河野 健一; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会関西支部第525回講演会, 27 May 2023

  
• 細菌の細胞外多糖が関与する細胞外膜小胞形成機構

  都築 大空; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  第69回日本生化学会近畿支部例会, 27 May 2023

  
• 細菌の細胞外膜小胞を認識する曲率認識ペプチドの結合特性の解析

  阪本 大輝; 井上 宙夢; 河野 健一; 今井 友也; 川本 純; 小川 拓哉; 倉田 淳志; 栗原 達夫

  日本農芸化学会2023年度大会, 16 Mar. 2023

  
• 低温菌 Shewanella livingstonensis Ac10 におけるβ酸化酵素を介したドコサヘキサエン酸から エイコサペンタエン酸への変換機構の解析

  正木 翼加; 小川 拓哉; 川本 純; 栗原 達夫

  日本農芸化学会2023年度大会, 15 Mar. 2023

  
• Shewanella vesiculosa HM13 由来細胞外膜小胞表層タンパク質の生理機能解析

  釜阪 紘平; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2023年度大会, 15 Mar. 2023

  
• Shewanella vesiculosa HM13 の細胞外膜小胞の積荷タンパク質輸送に関与する表層多糖合成酵素ホモログの解析

  都築 大空; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2023年度大会, 15 Mar. 2023

  
• 曲率認識ペプチドを用いた Shewanella vesiculosa HM13 の膜小胞生産関連遺伝子の網羅的探索と機能推定

  井上 宙夢; 河野 健一; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2023年度大会, 15 Mar. 2023

  
• 曲率認識ペプチドを用いた細菌細胞外膜小胞生産関連遺伝子のゲノム網羅的探索と機能推定

  井上 宙夢; 河野 健一; 川本 純; 小川 拓哉; 栗原 達夫

  極限環境生物学会2022年度（第23回）年会, 13 Nov. 2022

  
• 細胞外膜小胞への積荷タンパク質輸送に関与する表層糖鎖合成酵素ホモログの機能

  都築 大空; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  第95回日本生化学会大会, 11 Nov. 2022

  
• Multi-omic analysis to assess the physiological changes in Escherichia coli caused by the lack of a novel lysophosphatidic acid acyltransferase (YihG)

  Nittikarn Suwanawat; Takuya Ogawa; Jun Kawamoto; Tatsuo Kurihara

  第95回日本生化学会大会, 09 Nov. 2022

  
• 細菌細胞表層の科学：膜リン脂質・膜小胞研究の新展開

  栗原 達夫

  大隅基礎科学創成財団 微生物コンソーシアム定例会, 17 Oct. 2022, Invited

  
• 細菌の膜生化学：膜リン脂質・膜小胞研究の新展開

  栗原 達夫; 川本 純; 小川 拓哉

  第34回植物脂質シンポジウム, 20 Sep. 2022, Invited

  
• Shewanella vesiculosa HM13 の細胞外膜小胞の形成とフラン脂肪酸合成との関連

  小川 拓哉; 中野 咲梨; 横山 文秋; 川本 純; 栗原 達夫

  第68回日本生化学会近畿支部例会, 28 May 2022

  
• 曲率認識ペプチドを用いたハイスループットスクリーニングによる細菌細胞外膜小胞形成関連遺伝子の探索

  井上 宙夢; 河野 健一; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2022年度大会, 18 Mar. 2022

  
• Identification and characterization of genes related to extracellular membrane vesicle production of Shewallena vesiculosa HM13

  Zhu Mengshan; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2022年度大会, 18 Mar. 2022

  
• Shewanella vesiculosa HM13 の細胞外膜小胞の積荷タンパク質の機能発現に関与する表層糖鎖生合成系遺伝子群の機能解析

  都築 大空; 釡阪 紘平; 劉 愈穎; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2022年度大会, 18 Mar. 2022

  
• Shewanella vesiculosa HM13 由来細胞外膜小胞の主要積荷タンパク質の生理的役割

  釡阪 紘平; 林 杏亮; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2022年度大会, 18 Mar. 2022

  
• 細菌の細胞外膜小胞へのタンパク質輸送に関与する遺伝子クラスター

  栗原 達夫

  第466回ビタミンB研究協議会, 05 Mar. 2022

  
• Mechanism of protein loading onto membrane vesicles of Shewanella vesiculosa HM13

  Tatsuo Kurihara

  EMBO Workshop on Bacterial Membrane Vesicles: Biogenesis, functions and medical applications, 24 Nov. 2021, Invited

  
• 曲率認識ペプチドを用いた Shewanella vesiculosa HM13 の細胞外膜小胞生産関連遺伝子の探索

  井上 宙夢; 河野 健一; 川本 純; 小川 拓哉; 栗原 達夫

  極限環境生物学会 2021 年度(第 22 回)年会, 20 Nov. 2021

  
• 細菌細胞外膜小胞へのタンパク質輸送に関与するII型分泌装置様輸送装置の特性解析

  玉田 梨恵; 榑林 俊樹; Liu Yuying; 川本 純; 小川 拓哉; 栗原 達夫

  第94回日本生化学会大会, 03 Nov. 2021

  
• In vitro characterization of lysophosphatidic acid acyltransferase (PlsC) from Escherichia coli

  Suwanawat Nittikarn; 小川 拓哉; 川本 純; 栗原 達夫

  第94回日本生化学会大会, 03 Nov. 2021

  
• Shewanella vesiculosa HM13 由来細胞外膜小胞への新奇タンパク質輸送機構に関する研究

  釜阪 紘平; 都築 大空; 川本 純; 今井 友也; 小川 拓哉; 栗原 達夫

  日本農芸化学会関西支部第515回講演会, 05 Jun. 2021

  
• 細胞外膜小胞生産菌の積荷タンパク質輸送における表層糖鎖合成酵素の機能

  都築 大空; 釜阪 紘平; Liu Yuying; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  第67回日本生化学会近畿支部例会, 29 May 2021

  
• Shewanella vesiculosa HM13 の菌体外膜小胞への積荷タンパク質輸送機構における表層多糖の生理的役割

  釡阪 紘平; 川本 純; 小川 拓哉; 栗原 達夫

  日本農芸化学会2021年度大会, 21 Mar. 2021

  
• Increase of extracellular membrane vesicle production by deletion of genes involved in outer membrane-peptidoglycan linkage of Shewanella vesiculosa HM13

  Mengshan Zhu; Takuya Ogawa; Jun Kawamoto; Tomoya Imai; Tatsuo Kurihara

  日本農芸化学会2021年度大会, 21 Mar. 2021

  
• 膜小胞高生産性細菌 Shewanella vesiculosa HM13 における細胞外膜小胞生産の分子基盤

  栗原 達夫

  日本農芸化学会2021年度大会, 20 Mar. 2021, Invited

  
• Mechanistic analysis of protein transport to extracellular membrane vesicles of a hypervesiculating bacterial strain, Shewanella vesiculosa HM13

  Tatsuo Kurihara; Kouhei Kamasaka; Chen Chen; Fumiaki Yokoyama; Tomoya Imai; Takuya Ogawa; Jun Kawamoto

  ASEMV2020 (Annual meeting of the American Society for Exosomes and Microvesicles), 17 Nov. 2020, Invited

  
• 細菌の細胞外膜小胞へのタンパク質輸送機構

  栗原 達夫

  令和2年度日本農芸化学会東北支部シンポジウム, 07 Nov. 2020, Invited

  
• 低温菌 Shewanella vesiculosa HM13 における膜小胞生産への膜リン脂質の関与

  中野 咲梨; 小川 拓哉; 川本 純; 栗原 達夫

  第21回極限環境生物学会年会, 31 Oct. 2020

  
• 低温菌 Shewanella livingstonensis Ac10 における ω-3 系高度不飽和脂肪酸の代謝様式の解析

  小川 拓哉; Yustina Yusuf; 川本 純; 栗原 達夫

  第21回極限環境生物学会年会, 31 Oct. 2020

  
• Shewanella vesiculosa HM13 の表層糖鎖合成酵素による細胞外膜小胞構造と積荷タンパク質輸送の制御

  都築 大空; 釜阪 紘平; Liu Yuying; 今井 友也; 川本 純; 小川 拓哉; 栗原 達夫

  第21回極限環境生物学会年会, 31 Oct. 2020

  
• 細胞外膜小胞へのタンパク質輸送における Wzxフ リッパーゼホモログの機能

  釜阪 紘平; 川本 純; 小川 拓哉; 栗原 達夫

  第93回日本生化学会大会, 16 Sep. 2020

  
• Comparative analysis of lysophosphatidic acid acyltransferase homologs

  Misaki Kuboshima; Nittikarn Suwanawat; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara

  第93回日本生化学会大会, Sep. 2020

  
• DHAからEPAへの代謝変換に関与するアシルCoAデヒドロゲナーゼ

  栗原 達夫

  第460回ビタミンB研究協議会, 29 Aug. 2020

  
• 膜小胞高生産性細菌におけるタンパク質の膜小胞への輸送機構

  栗原達夫

  日本農芸化学会2020年度大会, 27 Mar. 2020, Invited

  
• 細菌のセンサータンパク質によるベシクル生産とバイオフィルム分散の誘導

  横山文秋; 今井友也; 川本純; 小川拓哉; 栗原達夫

  日本農芸化学会2020年度大会, 27 Mar. 2020

  
• 菌体外膜小胞へのタンパク質輸送における細胞表層構造制御タンパク質の機能

  釜阪紘平; 陳晨; 川本純; 小川拓哉; 栗原達夫

  日本農芸化学会2020年度大会, 27 Mar. 2020

  
• リゾホスファチジン酸アシル基転移酵素ホモログの比較解析

  久保嶋美咲; Nittikarn Suwanawat; 川本純; 小川拓哉; 栗原達夫

  日本農芸化学会2020年度大会, 27 Mar. 2020

  
• In vitro and In vivo analysis of FadH protein from Shewanella livingstonensis Ac10 involved in DHA conversion

  Yustina Yusuf; 廣瀬和樹; 川本純; 小川拓哉; 栗原達夫

  日本農芸化学会2020年度大会, 27 Mar. 2020

  
• Regulation of vesiculation and biofilm dispersion of Shewanella vesiculosa HM13 in response to extracellular environment

  Fumiaki Yokoyama; Tomoya Imai; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara

  3rd Bacterial Cell Biology Conference, Feb. 2020

  
• 低温菌 Shewanella vesiculosa HM13 のセンサータンパク質によるベシクル生産およびバイオフィルム分散の制御

  横山文秋; 今井友也; 川本純; 小川拓哉; 栗原達夫

  第20回極限環境生物学会年会, 16 Nov. 2019

  
• 細菌の細胞外膜小胞へのタンパク質積み込みにおける膜表層構造の機能

  釜阪紘平; 陳晨; 川本純; 小川拓哉; 栗原達夫

  第20回極限環境生物学会年会, 16 Nov. 2019

  
• タンパク質分泌生産に秀でた低温菌 Pseudoalteromonas nigrifaciens Sq02 を用いた低温タンパク質生産システムの開発

  河合総一郎; Aken Puti Wanguyun; 川本純; 小川拓哉; 栗原達夫

  第20回極限環境生物学会年会, 16 Nov. 2019

  
• 低温菌 Shewanella livingstonensis Ac10 におけるリゾホスファチジン酸アシル基転移酵素 PlsC5 の機能解析

  久保嶋美咲; 小川拓哉; 川本純; 栗原達夫

  第20回極限環境生物学会年会, 16 Nov. 2019

  
• Shewanella livingstonensis Ac10 の多価不飽和脂肪酸の変換における FadE の役割

  Yustina Yusuf; 廣瀬和樹; 小川拓哉; 川本純; 栗原達夫

  第20回極限環境生物学会年会, 16 Nov. 2019

  
• 細菌の菌体外膜小胞を介した選択的タンパク質分泌における細胞表層構造の役割

  釜阪紘平; Chen Chen; 小川拓哉; 川本純; 栗原達夫

  第92回日本生化学会大会, 20 Sep. 2019

  
• Polyunsaturated fatty acid conversion in Shewanella livingstonensis Ac10

  Yusina Yusuf; 廣瀬和樹; 小川拓哉; 川本純; 栗原達夫

  第92回日本生化学会大会, 18 Sep. 2019

  
• 低温菌 Pseudoalteromonas nigrifaciens Sq02 を用いた外来タンパク質低温分泌生産システムの構築と分泌機構の解明

  河合総一郎; Aken Puti Wanguyun; 川本純; 小川拓哉; 栗原達夫

  第71回日本生物工学会大会, 16 Sep. 2019

  
• 細菌におけるDHAからEPAへの代謝変換機構の解析

  栗原達夫

  第457回ビタミンB研究協議会, 30 Aug. 2019

  
• 細菌生体膜機能発現の分子基盤: 膜リン脂質・膜小胞研究の新展開

  栗原達夫

  第33回 ケミカルバイオロジー研究所セミナー／第105回 生物科学フロンティアセミナー, 07 Aug. 2019, Invited

  
• Shewanella 属細菌における新規エイコサペンタエン酸生産経路の解析

  小川拓哉; 廣瀬和樹; 川本純; 栗原達夫

  酵素・補酵素研究会2019, 04 Jul. 2019

  
• バイオフィルム分散関連タンパク質BdlAホモログの細菌ベシクル中からの同定

  横山文秋; 川本純; 小川拓哉; 今井友也; 栗原達夫

  第33回バイオフィルム学会学術集会, Jul. 2019

  
• 細菌における長鎖多価不飽和脂肪酸結合型タンパク質の探索

  川本純; 米田雄紀; 小川拓哉; 栗原達夫

  第61回日本脂質生化学会, Jul. 2019

  
• 海洋性Shewanella属細菌によるω-3系高度不飽和脂肪酸の変換経路の解明

  小川拓哉; 廣瀬和樹; 川本純; 栗原達夫

  第66回日本生化学会近畿支部例会, 25 May 2019

  
• Shewanella sp. HM13 における菌体外膜小胞を介したタンパク質分泌機構における細胞表層構造の働き

  釜阪紘平; Chen Chen、Liu Yuying; 川本純; 小川拓哉; 栗原達夫

  第66回日本生化学会近畿支部例会, 25 May 2019

  
• バイオフィルム分散に関与するセンサータンパク質のホモログを介した細菌ベシクル生産制御

  横山文秋; 川本純; 今井友也; 小川拓哉; 栗原達夫

  第66回日本生化学会近畿支部例会, 25 May 2019

  
• 細菌におけるEPA含有リン脂質の生合成・機能・細胞内分布

  栗原 達夫

  第5回 JFAS Japan/ Joy of Fatty Acids Secrets/ Society, 10 Mar. 2018, Invited

  
• 細菌生体膜研究の新展開：膜リン脂質の機能と膜小胞

  栗原 達夫

  京都府立大学生命分子化学科セミナー, 17 Nov. 2017, Invited

  
• Biosynthesis of phospholipids containing eicosapentaenoic acid and development of a molecular probe to analyze its in vivo function

  KURIHARA Tatsuo

  Japan-Italy Bilateral Symposium, 18 Oct. 2017, Invited

  
• 細菌の膜リン脂質の多様性：その生合成と機能

  栗原 達夫

  日本膜学会第39年会, 27 May 2017, Invited

  
• 細菌におけるエイコサペンタエン酸の生理機能

  栗原 達夫

  日本農芸化学会大会, 20 Mar. 2017, Invited

  
• 細菌細胞膜におけるリン脂質の分子種特異的機能と生合成酵素群の特性

  栗原 達夫

  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）, 04 Dec. 2015, Invited

  
• Distinct roles of 1-acylglycerol-3-phosphate O-acyltransferase isozymes in membrane phospholipid biogenesis in Shewanella livingstonensis Ac10

  KURIHARA Tatsuo

  18th Japanese-German Workshop on Enzyme Technology, 14 Sep. 2015, Invited

  
• エイコサペンタエン酸含有リン脂質の細菌細胞膜における機能とその生合成酵素群の特性

  栗原 達夫

  第15回日本蛋白質科学会年会, 24 Jun. 2015, Invited

  
• Membrane Microdomain Enriched in Eicosapentaenoic Acid-Containing Phospholipids in Shewanella livingstonensis Ac10

  KURIHARA Tatsuo

  Japan-Italy Joint Symposium, 05 Nov. 2014, Invited

  
• 低温菌の環境適応を担う細胞膜脂質

  栗原 達夫

  第29回日本微生物生態学会大会, 25 Nov. 2013, Invited

  
• 化学的アプローチによる高度不飽和脂肪酸含有リン脂質の生理機能解析

  日本薬学会第133年会, 29 Mar. 2013, 日本薬学会, Invited

  
• 細菌における高度不飽和脂肪酸含有リン脂質の生合成と機能

  日本農芸化学会大会, 27 Mar. 2013, 日本農芸化学会, Invited

  
• 好冷性細菌の低温適応を担う分子基盤：細胞膜における高度不飽和脂肪酸の機能

  新化学技術推進協会講演会, 29 Nov. 2012, 新化学技術推進協会, Invited

  
• 地球環境と微生物

  京都化学者クラブ講演会, 06 Oct. 2012, 近畿化学協会, Invited

  
• Function of Eicosapentaenoic Acid-Containing Phospholipids in Bacterial Cell Membrane

  Hirschegg Summer School 2012, 06 Sep. 2012, Max Planck Gesellschaft, Invited

  
• 生体膜における高度不飽和脂肪酸含有リン脂質の機能

  京都大学学際融合教育研究推進センター生理化学研究ユニット第2回シンポジウム, 13 Jun. 2012, 京都大学生理化学研究ユニット, Invited

  
• Molecular Probes to Analyze the Dynamics of Eicosapentaenoic-Acid-Containing Phospholipids and Their Interaction with Membrane Proteins

  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II], 29 Jun. 2011, 内藤記念科学振興財団

  
• 細菌細胞膜におけるリン脂質の局在化と生理機能

  京都大学微生物科学寄附研究部門主催シンポジウム, 23 Jun. 2011, 京都大学微生物科学寄附研究部門, Invited

  
• Function of Phospholipids Containing Eicosapentaenoic Acid in the Bacterial Cell Membrane

  Wageningen University and Research Centre/Kyoto University Joint Workshop, 26 Apr. 2011, 京都大学化学研究所

  
• Phospholipids involved in cold adaptation of an Antarctic psychrotrophic bacterium, Shewanella livingstonensis Ac10

  NAIST Global COE International Symposium 2009 Environmental Adaptation, 13 Nov. 2009, 奈良先端科学技術大学院大学

  
• 新規有機ハロゲン化合物変換酵素の開発と応用

  第61回日本生物工学会大会, 25 Sep. 2009, 日本生物工学会, Invited

  
• 特殊環境微生物の環境適応を担う分子基盤の解明と応用

  北海道大学講演会, 15 Dec. 2008, 北海道大学農学部, Invited

  
• A Novel Flavoenzyme Involved in Bacterial Metabolism of 2-Chloroacrylate

  4th Japan-Finland Biotechnology Symposium, 02 Oct. 2008

  
• 特殊環境微生物の環境適応機構の解析と応用

  奈良女子大学理学部化学科講演会, 10 Jul. 2008, 奈良女子大学理学部, Invited

  
• Cold-adaptation Mechanisms and Applications of an Antarctic Psychrotrophic Bacterium, Shewanella livingstonensis Ac10

  BIT's 1st Annual World Congress of ibio-2008, Hangzhou, China, 19 May 2008

  
• 低温菌の低温適応機構の解析と外来タンパク質生産への応用

  SHIMADZU BIOTECH ライフサイエンスセミナー, 20 Dec. 2006, 島津製作所, Invited

  
• 低温菌の低温適応機構の解析とタンパク質低温生産への応用

  生化学会近畿支部会シンポジウム, 13 Jul. 2006, 日本生化学会近畿支部, Invited

  
• Enzymatic conversion of organohalogen compounds: reaction mechanisms and applications

  Pacifichem 2005, 18 Dec. 2005

  
• 低温菌の低温適応機構の解析とタンパク質低温生産システムの開発

  産業技術総合研究所 RICE セミナー, 産業技術総合研究所, 10 Jun. 2005, 産業技術総合研究所, Invited

  
• 低温菌の低温適応機構の解析と応用

  分子生物学会第27回年会, 11 Dec. 2004, 日本分子生物学会, Invited

  
• 好冷微生物を用いたタンパク質高生産システムの構築

  酵素工学研究会第52回講演会, 02 Nov. 2004, 酵素工学研究会, Invited

  
• 低温菌のプロテオーム解析と応用

  ミニ国際シンポジウム：マリンゲノムの新展開「深海微生物のゲノム生物学」, 08 Oct. 2004, Invited

  
• 有機ハロゲン化合物の微生物酵素変換：精密反応解析による新しい分子論展開と応用

  日本農芸化学会関西支部講演会, 29 May 2004, 日本農芸化学会関西支部, Invited

  
• 有機ハロゲン化合物の微生物酵素変換：反応機構解析と応用

  新化学発展協会ライフサイエンス技術部会講演会, 11 Sep. 2003, 新化学発展協会, Invited

  
• Biogenesis of Sulfur-Containing Biofactors

  Colorado State University, Biology Department Seminar, 05 Sep. 2003

  
• 質量分析で探る酵素反応のメカニズム

  日本生物工学若手会, 20 Jul. 2002, 日本生物工学会, Invited

  
• Assembly of Iron-Sulfur Clusters Mediated by Pyridoxal Phosphate-Dependent Cysteine Desulfurase

  3rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins, 18 Apr. 2002

  
• Studies of Structures, Functions and Reaction Mechanisms of Enzymes Degrading Organohalogen Compounds

  Novozymes Japan Enzyme Symposium 2001, 21 Sep. 2001, Novozymes Japan

  
• 質量分析法による酵素触媒機構の研究

  日本農芸化学会大会, 25 Mar. 2001, 日本農芸化学会, Invited

  
• Cold-Active Enzymes from Cold-Adapted Microorganisms

  2000 International Chemical Congress of Pacific Basin Societies, 15 Dec. 2000

  
• 小胞体からゴルジ体への小胞輸送における新規コートタンパク質 Lst1p の機能

  酵母研究会, 25 Mar. 1999, 酵母研究会, Invited

  
• Characteristics of DL-2-Haloacid Dehalogenases

  Academy Colloquium: Mechanisms of Halogenation and Dehalogenation, 17 Sep. 1996

  
• Nitroalkane-oxidizing Enzymes

  12th International Symposium on Flavins and Flavoproteins, 04 Jul. 1996

  

Books and Other Publications

• バイオフィルム革新的制御技術

  栗原達夫, Contributor, 細菌の細胞外膜小胞へのタンパク質輸送メカニズム

  エヌ・ティー・エス, Jun. 2023

  Find Kyoto University's collection of books :

  
• 「不飽和脂肪酸から探る生体膜の機能形成」CSJ カレントレビュー 30 生命機能に迫る分子化学, 50-55

  栗原達夫

  化学同人, 2018, Not refereed

  
• "Proteomic Insights of Psychrophiles" Psychrophiles: From Biodiversity to Biotechnology Second Edition

  Kawamoto, J; Kurihara, T; Esaki, N, Joint work, 423-435

  Springer, 2017, Not refereed

  
• 「ペントースリン酸経路」、「ホスホケトラーゼ経路によるヘテロ乳酸発酵」、「Stickland 反応」応用微生物学第3版

  栗原達夫

  文永堂出版株式会社, Aug. 2016, Not refereed

  
• 「低温菌のタンパク質と脂質」CSJ カレントレビュー 17 極限環境の生体分子, 55-61

  川本純; 栗原達夫

  化学同人, 2014, Not refereed

  
• 「長鎖多価不飽和脂肪酸エイコサペンタエン酸の生理機能」医学のあゆみ, 1221-1227

  栗原達夫; 川本純

  医歯薬出版株式会社, 2014, Not refereed

  
• "Proteins Involved in Cold Adaptation" Cold-Adapted Microorganisms, 97-110

  Yoshimune, K; Kawamoto, J; Kurihara, T

  Caister Academic Press, 2013, Not refereed

  
• 「好冷性微生物の活用」極限環境微生物の産業展開, 131-136

  栗原達夫

  シーエムシー出版, 2012, Not refereed

  
• 「遺伝子工学で用いる酵素」基礎生物学テキストシリーズ１０ 遺伝子工学, 15-30

  栗原達夫

  化学同人, 2012, Not refereed

  
• 「好冷酵素の特性と利用法」酵素利用技術体系, 239-243

  栗原達夫

  エヌ・ティー・エス, 2010, Not refereed

  
• 「有機ハロゲン化合物代謝関連酵素」酵素利用技術体系, 88-92

  栗原達夫

  エヌ・ティー・エス, 2010, Not refereed

  
• 「細胞がセレンをタンパク質に取り込む機構の解析とその応用」メタルバイオテクノロジーによる環境保全と資源回収, 241-246

  栗原達夫; 三原久明; 江崎信芳

  シーエムシー出版, 2009, Not refereed

  
• "Proteomic Studies of Psychrophilic Microorganisms" Psychrophiles: from Biodiversity to Biotechnology, 333-344

  Kurihara, T; Esaki, N

  Springer, 2008, Not refereed

  
• 「プラスミドの調製」、「バクテリオファージの調製」、「mRNA の調製と cDNA ライブラリー作製」実験化学講座 第５版 ２９ バイオテクノロジーの基本技術, 93-118

  栗原達夫

  丸善, 2006, Not refereed

  
• 「好冷性酵素」酵素開発・利用の最新技術, 24-31

  栗原達夫; 江崎信芳

  シーエムシー出版, 2006, Not refereed

  
• 「化学的解析に基づく反応機構」タンパク質科学, 389-399

  栗原達夫; 江崎信芳

  化学同人, 2005, Not refereed

  
• 「脂質と生体膜」他 生化学基礎の基礎, 7-10他

  栗原達夫

  化学同人, 2002, Not refereed

  
• "Isomerizations" Enzyme Catalysis in Organic Synthesis, Second Edition 3, 1281-1332

  Esaki, N; Kurihara, T; Soda, K

  Wiley, 2002, Not refereed

  
• 「遺伝子の人為的改変」微生物利用の大展開, 507-514

  栗原達夫

  エヌ・ティー・エス, 2002, Not refereed

  
• "Enzymology of Amino Acid Production" Biotechnology, 505-560

  Esaki, N; Nakamori, S; Kurihara, T; Furuyoshi, S; Soda, K

  Wiley, 1996, Not refereed

  

Industrial Property Rights

• 特開2014-050325, 特願2012-195095, 乳酸菌の低温増殖性改善方法

  後藤 清太郎; 工藤 和幸; 栗原 達夫; 川本 純

  
• 特開2005-176825, 特願2004-101560, 好冷微生物を利用したタンパク質の生産法及び環境浄化法

  江崎 信芳; 栗原 達夫

  
• 特開2005-176826, 特願2004-101569, 新規プロモーター及びその利用

  江崎 信芳; 栗原 達夫

  
• 特願2005-517459, レーザ分析装置及び方法

  清水 政二; 阪部 周二; 橋田 昌樹; 加藤 詩子; 栗原 達夫; 梅田 真郷; 江崎 信芳

  
• 特願2003-566211, α－置換－α，β－不飽和カルボニル化合物の還元酵素遺伝子

  蒲池 晴美; 江崎 信芳; 栗原 達夫

  

Works

• 植物と微生物におけるセレン代謝酸素の機能解析および環境浄化への応用

  From 2001

  
• In Vivo and in vitro analysis of selenium metabolism- a multidisciplinary approach

  From 2001

  

Awards

• 28 Mar. 2004

  Japan Bioscience, Biotechnology and Agrochemistry Society, The Japan Bioscience, Biotechnology and Agrochemistry Society Award for the Encouragement of Young Scientists
• 21 Sep. 2001

  Novozymes Japan, Novozymes Japan Enzyme Symposium Award
• 25 Apr. 2014

  Nagase Science and Technology Foundation, Nagase Foundation Award

External funds: Kakenhi

• Molecular basis for generation of the diversity of bacterial membrane phospholipid acyl chains and mechanisms underlying their physiological functions

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  栗原 達夫

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  生体膜;リン脂質;リゾホスファチジン酸アシル基転移酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02102/
• Dissection of the molecular basis of membrane vesicle biogenesis and construction of an extracellular platform for substance production by using a hyper-vesiculating bacterium

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  栗原 達夫

  From 30 Jul. 2020, To 31 Mar. 2023, Granted

  細胞外膜小胞;タンパク質輸送;タンパク質分泌;表層多糖;膜タンパク質;多糖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20570/
• Elucidation of the mechanism of extracellular membrane vesicle production with a novel bacterium that abundantly produces vesicles and their application

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  Tatsuo KURIHARA

  From 29 Jun. 2018, To 31 Mar. 2021, Project Closed

  細胞外膜小胞;タンパク質輸送;タンパク質分泌;表層糖鎖;表層糖脂質;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19178/
• Diversity of acyl groups of phospholipids in bacterial cell membranes: Its generation mechanism and physiological significance

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  生体膜;リン脂質;リゾホスファチジン酸アシル基転移酵素;高度不飽和脂肪酸;PlsC;分岐鎖脂肪酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02127/
• Exploration and development of cold-adapted microorganisms useful in low-temperature biotechnology for chemical production and environmental conservation

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  好冷性微生物;低温菌;特殊環境;バイオテクノロジー;物質生産;タンパク質生産;タンパク質分泌生産;応用微生物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04598/
• Analysis of Cold-Adaptation Mechanism of Food Spoilage Bacteria and Its Application to Food Industry

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  低温増殖性細菌;食品変敗;低温適応機構;表層タンパク質;タンパク質生産;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14732/
• Mechanism of Biogenesis of Membrane Microdomain Containing Polyunsaturated Fatty Acids in Bacteria and Its Physiological Functions

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  生体膜;高度不飽和脂肪酸;エイコサペンタエン酸;リン脂質;アシル化タンパク質;マイクロドメイン;細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04474/
• Application of eicosapentaeonic acid-containing phospholipids as a lipophilic protein chaperone

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Jun Kawamoto

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  低温菌;エイコサペンタエン酸;Outer membrane vesicle;Shewanella;リン脂質;特殊環境微生物;高度不飽和脂肪酸;長鎖多価不飽和脂肪酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26660065/
• Exploration of Cold-Adapted Microorganisms to Develop Low-Temperature Bioprocessing Systems

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  低温適応微生物;バイオプロセス;タンパク質生産;金属代謝;国際研究者交流;国際情報交換;中華人民共和国;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25303028/
• Development of Biocatalysts for Remediation of Environments Polluted with Persistent Organohalogen Compounds

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  酵素;応用微生物;有機ハロゲン化合物;デハロゲナーゼ;フルオロ酢酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24658275/
• Exploration of functional-metal nano particle-producing bacteria from extremophile environments

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun Kawamoto

  From 01 Apr. 2012, To 31 Mar. 2016, Project Closed

  金属ナノ粒子;極限環境微生物;低温菌;菌体外膜小胞;特殊環境微生物;金属呼吸;微生物機能

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24405030/
• Functional analysis and application of phospholipids containing polyunsaturated fatty acids in bacterial cell membrane

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2012, To 31 Mar. 2016, Project Closed

  細胞膜;脂質;タンパク質;高度不飽和脂肪酸;エイコサペンタエン酸;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24380047/
• Investigation of Chaperone Function of Phospholipids Containing Polyunsaturated Fatty Acids and Their Application to Overproduction of Membrane Proteins

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  微生物;生体膜;高度不飽和脂肪酸;エイコサペンタエン酸;リン脂質;膜タンパク質;フォールディング;ポーリン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658028/
• Exploration of cold-adapted microorganisms for development of new low-temperature biotechnological processes

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  特殊環境微生物;低温菌;好冷性酵素;分子育種;国際研究者交流;国際情報交換;オーストリア;メタル代謝;高度不飽和脂肪酸;ドイツ;生物・生体工学;低温適応微生物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22404021/
• Exploration of novel metal-metabolizing bacterium to develop the purification of rare metal pollution and recovery system of rare metal

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun KAWAMOTO

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  バイオテクノロジー;応用微生物;生体機能利用;微生物機能;環境浄化;金属呼吸;環境技術;微生物;金属代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21405038/
• Analysis of the molecular basis for cold adaptation of psychrotrophic bacteria

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  微生物;特殊環境;好冷微生物;低温適応;生体膜;タンパク質;脂質;生物・生体工学;高度不飽和脂肪酸;エイコサペンタエン酸;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20360372/
• Exploration of novel cold-adapted microorganisms to develop a systemfor the production of useful compounds at low temperatures

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  低温適応微生物;低温菌;好冷菌;低温物質生産;低温誘導性遺伝子;タンパク質分泌生産

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19404020/
• Structure and function of selenium-specific chemical conversion system and co-translational insertion of selenium into proteins

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobuyoshi ESAKI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  タンパク質;酵素;微量必須元素;セレン;セレンタンパク質;生合成;翻訳;必須微量元素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19370040/
• Investigation of organisms having unique selenium metabolic pathways and its application to bioremediation

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobuyoshi ESAKI

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  セレン;セレンタンパク質;セレノシステイン;必須微量元素;代謝;微生物, selenium;selenoprotein;selenocysteine;essential trace element;metabolism

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18405042/
• Exploration of Novel Cold-adapted Microorganisms That Inhabit the Polar Regions and Investigation of Their Useful Enzymes

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  低温菌;好冷菌;低温活性酵素;有用酵素;有用遺伝子;応用微生物;特殊環境, psychrotroph;psychrophile;cold-active enzyme;useful enzyme;useful gene;applied microbiology;unusual environment

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17404021/
• Dynamics of the essential trace element selenium in mammals and molecular basis for selenoprotein biosynthesis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobuyoshi ESAKI

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  セレン;セレンタンパク質;セレノシステイン;必須微量元素;酵素;翻訳;SECIS;セレノシステインリアーゼ, selenium;selenoprotein;selenocysteine;essential trace element;enzyme

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17370037/
• Conversion of Organofluorine Compounds with Microbial Enzymes : Mechanistic Analysis of the Enzyme Reactions and Their Application to Production of Useful Compounds and Bioremediation of Environments

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuo KURIHARA

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  有機ハロゲン化合物;有機フッ素化合物;脱ハロゲン;デハロゲナーゼ;フルオロ酢酸デハロゲナーゼ;還元的脱ハロゲン化酵素, organohalogen compound;organofluorine compound;dehalogenation;dehalogenase;fluoroacetate dehalogenase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17360397/
• 封入体形成を抑制する低温タンパク質生産システムの開発

  Grant-in-Aid for Exploratory Research

  Kyoto University

  栗原 達夫

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  低温菌;好冷菌;タンパク質生産;宿主ベクター系;プロモーター;ターミネーター;Shewanella

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16658044/
• Screening of novel cold-adapted microorganisms and exploitation of their useful gene resources

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  好冷微生物;好冷菌;低温菌;低温活性酵素;宿主-ベクター系;タンパク質生産;Pseudomonas;プロテアーゼ;分泌生産;TypeI分泌装置, cold-adapted microorganism;psychrophile;psychrotroph;cold-active enzyme;host-vector system;protein production

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15405045/
• Analysis of the mechanism of activation and co-translational insertion of an essential trace element, selenium, into polypeptide

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  セレン;セレノシステインリアーゼ;セレンタンパク質;フィトレメディエーション;RNAi;X線結晶構造解析;培養細胞;HeLa;脳;セレン欠乏, selenium;selenocysteine lyase;selenoprotein;phytoremediation;RNAi;x-ray crystal structural analysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15370043/
• 有機フッ素化合物のバイオコンバージョン:フッ素脱離・導入の酵素触媒機構と応用

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  栗原 達夫

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  フルオロ酢酸デハロゲナーゼ;有機フッ素化合物;脱ハロゲン;2-ハロアクリル酸レダクターゼ;有機ハロゲン化合物;不斉還元;Burkholderia;2-クロロプロピオン酸;フルオロ酢酸;2-ハロ酸;2-ハロ酸デハロゲナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14703021/
• Studies of physiological function of D-aspartate in eukaryotic cells : from yeasts to mammals

  Grant-in-Aid for Scientific Research (C)

  Nagoya University;Kyoto University

  Ryuichi MORIYAMA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  D-アミノ酸;真核細胞;ラセマーゼ;酵母;D-アミノ酸N-アセチルトランスフェラーゼ;N-アセチル-D-アミノ酸;D-アミノ酸 N-アセチルトランスフェラーゼ;分裂酵母, D-amino acid;racemase;eukaryote;yeast;D-amino acid N-acetyltransferase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14560064/
• Whole-genome sequencing of a psychrophilic bacterium, analysis of genes involved in cold adaptation, and exploitation of cold-active enzymes

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  好冷細菌;好冷菌;低温菌;Shewanella;Acinetobacter;ゲノム解析;低温適応;低温活性酵素;好冷酵素;形質転換;宿主-ベクター系;Shewanella sp.Ac10;Acinetobacter sp.strain no.6;宿主ベクター系;脂質分解酵素, psychrophilic bacteria;psychrophiles;psychrotrophs;Shewanella;Acinetobacter;genome analysis;cold adaptation;cold-active enzymes

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13556014/
• Dynamism of activated-selenium species: Structural biological analysis of mechanism of biosynthesis of selenium-containing proteins

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobuyoshi ESAKI

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  セレノシステイン;セレノシステインリアーゼ;セレン;セレンタンパク質;セレン活性分子種;部位特異的変異;X線結晶構造解析;プロパルギルグリシン, selenocysteine;selenocysteine lyase;selenium;selenoprotein;activated-selenium species

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13480192/
• ファージを用いた水系中の微量物質の回収と除去

  Grant-in-Aid for Exploratory Research

  Kyoto University

  吉村 徹

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  環境浄化;ファージディスプレイ;バイオパニング;無担体バイオパニング法;D-アミノ酸;アラニンラセマーゼ;浸透圧調整;D-アミノ酸オキシダーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12878100/
• 古細菌の蛋白質膜透過機構の解明と高度好塩古細菌を宿主とした膜蛋白質高生産系の構築

  Grant-in-Aid for Exploratory Research

  Kyoto University

  江崎 信芳

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  古細菌;高度好塩古細菌;蛋白質膜透過;SecY;SecE;膜蛋白質;Haloferax volcanii;蛋白質膜透過機構

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12876021/
• 含硫黄・含セレンバイオファクターの構造形成を司る類縁酵素群の構造・機能・役割分担

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  栗原 達夫

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  システインデスルフラーゼ;セレノシステインリアーゼ;鉄硫黄クラスター;ピリドキサールリン酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12780470/
• Isolation of novel psychrophilic microorganisms and exploitation of useful enzymes

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  好冷細菌;好冷菌;低温菌;Acinetobacter;低温活性酵素;脂質分解酵素;リパーゼ;エステラーゼ;Acinetobactor;好冷酵素;プロテアーゼ, psychrophilic bacteria;psychrochilic microorganisms;psychrotrophic microorganisms;Acinetobacter;cold-active enzymes;lipolytic enzymes;lipases;esterases

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12575019/
• 高度好塩始原菌における細胞表層蛋白質生合成機構の解明と応用

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  江崎 信芳

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  始原菌;Haloferax volcanii;細胞表層蛋白質;蛋白質膜透過機構;SecY

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12019239/
• Role of D-amino acid in adaptation of organisms to environmental change

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Tohru YOSHIMURA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  D-アミノ酸;アラニンラセマーゼ;浸透圧調整;D-アミノ酸オキシダーゼ;ラセマーゼ, D-amino acid;alanine racemase;D-aminoacid oxidase;osmolite

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11691187/
• Development of dehalogenases by molecular evolution technology : Application of production of useful materials and bioremediation of environments

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Kurihara TATSUO

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  有機ハロゲン化合物;L-2-ハロ酸デハロゲナーゼ;DL-2-ハロ酸デハロゲナーゼ;フルオロ酢酸デハロゲナーゼ;Burkholderia属細菌;立体構造モデリング;炭素-フッ素結合;ハロ酸デハロゲナーゼ;Methylobacterium属細菌;クロロプロピオン酸, organohalogen compounds;L-2-haloacid dehalogenase;DL-2-haloacid dehalogenase;fluoroacetate dehalogenase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11558084/
• Roles and specific functions of homologous enzymes involved in biogenesis of active-form sulfur and active-form selenium

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  セレノシステインリアーゼ;システインデスルフラーゼ;セレノリン酸;セレン;鉄硫黄クラスター;硫黄, selenocysteine lyase;cysteine desulfurase;selenophosphate;selenium;iron-sulfur cluster;sulfur

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11480179/
• ファージディスプレーを用いた進化分子工学による酵素機能の改変

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  江崎 信芳

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  ファージディスプレー;進化分子工学;DnaK;グルタミン酸ラセマーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11132236/
• Investigation of halophilic microorganisms in salt lakes and development of novel halogenating and dehalogenating enzymes

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  塩湖;ハロゲン代謝;ハロゲン化酵素;脱ハロゲン酵素, Salt lake;halogen metabolism;halogenating enzyme;dehalogenating enzyme

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10041167/
• Structural and functional analysis of microbial enzymes catalyzing defluorination and fluorination

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  フルオロ酢酸デハロゲナーゼ;L-2-ハロ酸デハロゲナーゼ;パラカタリティック失活反応;結晶構造解析;立体構造モデリング;脱ハロゲン;フッ素;ヒドロキシルアミン;アンモニア;2-ハロ酸デハロゲナーゼ;Asp105, fluoroacetate dehalogenase;L-2-haloacid dehalogenase;paracatalytic inactivation;crystal structural analysis;homology modeling;dehalogenation;fluorine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09460049/
• フルオロ酢酸デハロゲナーゼによる炭素-フッ素結合の切断機構

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  栗原 達夫

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  フルオロ酢酸デハロゲナーゼ;反応機構;部位特異的変異;タンデムMS;MS法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08760080/
• アラニンラセマーゼのシャペロン様機能性ドメイン

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  吉村 徹

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  アラニンラセマーゼ;断片型酵素;ドメイン;リフォルディング;高次構造形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08272213/
• ハロ酸の酵素的分解機構の解析とその環境浄化への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  江崎 信芳

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  デハロゲナーゼ;2‐ハロ酸;フルオロ酢酸;触媒機構;エステル中間体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08255224/
• 2-ハロ酸デハロゲナーゼの構造と反応機構の解析、それに基づく酵素機能の改変

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  栗原 達夫

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  加水分解的脱ハロゲン反応;デハロゲナーゼ;L-2-ハロ酸デハロゲナーゼ;DL-2-ハロ酸デハロゲナーゼ;反応機構;活性中心

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07780535/
• 酵素による立体選択的酸化と電極還元を組合せた新規キラル合成法開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  左右田 健次

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  立体選択的酸化;電極還元;D-アミノ酸オキシダーゼ;L-アミノ酸オキシダーゼ;プロリン;ピペコリン酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07215238/
• Screening of New Psychrophiles Producing Useful Enzymes

  Grant-in-Aid for international Scientific Research

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  極限環境微生物;低温菌;好冷酵素;リパーゼ;エステラーゼ;クローニング;好冷菌;ツンドラ;エステル分解;エステル合成, psychrophilic enzyme;psychrotrophic bacteria;psychrophilic bacteria;Pseudomonas;Acinetobacter;cloning;lipase;beta-ketoadipate enol lactone hydrolase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07041108/
• 分断型アラニンラセマーゼの分子構造形成における細胞内マトリツクスの相互作用

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  左右田 健次

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  アラニンラセマーゼ;ドメイン;断片型酵素;分子シャペロン;フォルディング;GroESL

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07229229/
• Biochemical and Molecular Biological Studies or Structure and Function of Glutamate Racemase

  Grant-in-Aid for General Scientific Research (C)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  グルタミン酸ラセマーゼ;遺伝子クローニング;Bacillus cereus;活性中心システイン残基;Composite active site;α,β-脱離反応;酵素自殺基質;セリンO-スルフェート;composite active site, glutamate racemase;gene cloning;Bacillus cereus;cysteine residue;composite active site;alpha, beta-elimination;suicide substrate;serine O-sulfate

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06680610/
• Application of Molecular Chaperone to Protein Engineering

  Grant-in-Aid for Developmental Scientific Research (B)

  KYOTO UNIVERSITY

  Nobuyoshi ESAKI

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  封入体;グルタミン酸ラセマーゼ;アラニンラセマーゼ;分子シャペロン;GroESL;タンパク工学, inclusion body;glutamate racemase;alanine racemase;molecular chaperone;GroESL;protein engineering

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06558097/
• Structure and Function of Enzymes Participating in Metabolism of D-Amino Acid of Bacterial Cell Walls and Development of their Specific Inhibitors

  Grant-in-Aid for General Scientific Research (B)

  KYOTO UNIVERSITY

  Kenji SODA

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  ペプチドグリカン;アラニンラセマーゼ;D-アミノ酸アミノトランスフェアーゼ;グルタミン酸ラセマーゼ;D-アミノ酸;酵素自殺基質;UDP-N-アセチルムラミル-L-アラニン;ピリドキサルリン酸;D-アミノ酸トランスアミナーゼ;セリンO-スルフェート;酵素阻害剤, D-Amino acid;Alanine Racemase;D-Amino acid aminotransferase;Glutamate racemase;Suicide substrate

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454077/
• 分断型アラニンラセマーゼの分子構造形成における細胞内マトリックスの相互作用

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  左右田 健次

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  アラニンラセマーゼ;断片型酵素;分子シャペロン;リフォルディング;GroESL

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06240231/
• 酵素による立体選択的酸化と電極還元を組合せた新規キラル合成法開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  左右田 健次

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  立体選択的酸化;電極還元;D-アミノ酸オキシダーゼ;L-アミノ酸オキシダーゼ;プロリン;ピペコリン酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06226237/
• 微生物のハロ酸デハロゲナーゼの分子生物学的研究と応用

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  栗原 達夫

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  2-ハロ酸デハロゲナーゼ;有機ハロゲン化合物;脱ハロゲン;2-クロロアクリル酸資化性菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05760069/
• Protein engineering studies of thermostable D-amino acid transaminase

  Grant-in-Aid for international Scientific Research

  Kyoto University

  Kenji SODA

  From 01 Apr. 1993, To 31 Mar. 1995, Project Closed

  好熱性細菌;耐熱性酵素;D-アミノ酸トランスアミナーゼ;ピリドキサルリン酸;X線結晶解析;ピリドキサル酵素;スクリーニング;タンパク質工学, thermophilic bacteria;thermostable enzymes;D-amino acid transaminase;pyridoxal phosphate;X-ray crystal structure analysis;pyridoxal enzymes;screening;protein engineering

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05044095/
• Enzymatic manipulation of biomembrane lipids to enhance cellular function

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  栗原 達夫

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  生体膜;リン脂質;リゾホスファチジン酸アシル基転移酵素;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17991/