Basic Information

Faculty

• 医学部

Professional Memberships

• From Sep. 2005, To Present

  日本鉄バイオサイエンス学会
• 日本癌学会
• 日本分子生物学会
• 日本生化学会

Academic Degree

• Doctor of Medical Science (equivalent to Ph. D)(Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, Graduate School of Medicine, Internal Medicine, 研究指導認定退学
• Kyoto University, Graduate School of Medicine, Internal Medicine, 修了

Academic Resume (Undergraduate School/Majors)

• Kyoto University, Faculty of Medicine, 卒業
• Kyoto University, 医学部医学進学課程, 修了

Research History

• From Oct. 2022, To Present

  Kyoto University, Provost/Executive Vice-President
• From Oct. 2018, To Sep. 2022

  Kyoto University, Graduate School of Medicine, Dean
• From Apr. 2012, To Present

  Graduate School of Medicine, Kyoto University, Professor
• From Apr. 2008, To Mar. 2012

  大阪大学大学院・生命機能研究科/医学系研究科, 教授
• From Jul. 2001, To Mar. 2008

  Graduate School of Medicine, Osaka City University, Professor
• From 1999, To 2001

  京都大学大学院・生命科学研究科 助教授
• From 1997, To 1999

  京都大学大学院・医学研究科 助教授
• From 1996, To 1997

  京都大学大学院・医学研究科 助手
• From 1993, To 1996

  National Institutes of Health
• From 1992, To 1993

  Kyoto University, Faculty of Medicine

Profile

• Profile

  1985年京都大学医学部卒業。臨床研修を経て92年京都大学大学院医学研究科博士課程内科系専攻修了。同年、同免疫研究施設助手。93年米国NIH研究員。96年京都大学助手。97年同助教授。2001年より大阪市立大学大学院医学研究科教授。2008年より大阪大学大学院生命機能研究科/医学系研究科教授。2012年より現職。2018-2022年京都大学医学研究科長・医学部長、2022年から京都大学理事・副学長。ユビキチン修飾系と鉄代謝・動態制御機構の研究を推進する。ユビキチンでは、ユビキチンシグナリング、ユビキチンによる炎症制御機構、NF-κB活性化機構、直鎖状ユビキチン鎖形成異常による自己炎症性疾患、自己免疫疾患の発症機構。鉄代謝・動態では細胞の鉄調節機構、鉄貯蔵タンパク質フェリチンの運命決定機構、フェロトーシス、フェロトーシスを制御するセレン代謝調節、鉄と老化・老化関連疾患の研究に従事しています。生物学のみならず化学、臨床医など多様なバックグラウンドを持った人たちと、原子間相互作用から個体まで広い視野か先入観を持つことなくサイエンスを見つめて研究を進めたいと考えており、種々の分野からの若い人たちの参加を待ち望んでいます。

Language of Instruction

• English

ID,URL

• J-Global ID

  200901077008313637

• Researcher number

  60252459

• External link

  http://www.med.kyoto-u.ac.jp/en/organization-staff/research/doctoral_course/r-004/

Website(s) (URL(s))

• https://www.mcp-kyoto-u.jp

researchmap URL

• https://researchmap.jp/Kazuhiro_Iwai

Research

Research Topics, Overview of the research

• Research Topics

  ubiquitin conjugation system
  Involvement of the ubiquitin system in the pathogenesis of inflammatory diseases and cancer
  Roles of the ubiquitin system played in NF-kappaB activation and cell death protection
  Iron metabolism

• Overview of the research

  The ubiquitin system was identified as a part of energy dependent degradation system. However, it is regarded as one of the most sophisticated reversible post-translational modification systems that regulates protein functions in various ways. Ubiquitin modifies proteins as ubiquitin chains in most cases. We have identified a brand-new linear ubiquitin chains and found that the linear chains regulate signaling (NF-kB activation and suppression of cell death). Also, abnormal generation of the linear chains underlies disease including autoinflammatory diseases, autoimmune disease and cancer. We also working on cellular iron metabolism and it is involvement in ferroptosis.

Research Interests

• cellular senescence
• cellular iron homeostasis
• selenium metabolism
• ubiquitin signaling
• linear ubiquitination
• autoinflammatory diseases
• autoimmune diseases
• ferroptosis
• iron metabolism
• NF-kB
• ubiquitin

Research Areas

• Life sciences, Pathobiochemistry
• Life sciences, Medical biochemistry
• Life sciences, Cell biology
• Life sciences, Functional biochemistry

Papers

• Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function

  Yusuke Toda; Hiroaki Fujita; Koshiki Mino; Takuto Koyama; Seiji Matsuoka; Toshie Kaizuka; Mari Agawa; Shigeyuki Matsumoto; Akiko Idei; Momoko Nishikori; Yasushi Okuno; Hiroyuki Osada; Minoru Yoshida; Akifumi Takaori-Kondo; Kazuhiro Iwai

  Cell Death & Disease, 11 Nov. 2024

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• Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice

  Kazuhiro Iwai

  Clinical & Experimental Immunology, 28 Jun. 2008

  
• In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone

  Kazuhiro Iwai

  Clinical & Experimental Immunology, 28 Jun. 2008

  
• The protein degradation system involved in the regulation of iron metabolism

  Iwai, K.

  Gan to kagaku ryoho. Cancer & chemotherapy, 2008

  
• Regulation of iron metabolism and its involvement in diseases

  Iwai, K.

  Rinsho byori. The Japanese journal of clinical pathology, 2008

  
• Various functions and toxicity of iron

  Sakata, S.; Iwai, K.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007

  
• Roles of the ubiquitin system in stress responses

  Iwai, K.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1999

  
• Clinical significance of anti-PCNA autoantibody assay

  Kumagai, S.; Iwai, K.

  Nippon rinsho. Japanese journal of clinical medicine, 1990

  
• Heterogeneity in terms of interleukin 4-dependent regulation of Fce receptor/CD23 expression on chronic B-lymphocytic leukemia cells

  Ishida, H.; Kumagai, S.; Iwai, K.; Takahashi, T.; Kawabe, T.; Yodoi, J.; Arai, N.; Namiuchi, S.; Konaka, Y.; Imura, H.

  Immunology Letters, 1989

  
• Crucial role of linear ubiquitin chain assembly complex–mediated inhibition of programmed cell death in tlr4-mediated b cell responses and b1b cell development

  Yoshiteru Sasaki; Kazuhiro Iwai

  Journal of Immunology, 15 May 2018

  
• Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

  Hirotsugu Oda; Kalpana Manthiram; Pallavi Pimpale Chavan/Pallavi Pimple/Pallavi Pimpale; Eva Rieser; Önay Veli; Öykü Kaya; Charles Rauch; Shuichiro Nakabo; Hye Sun Kuehn; Mariël Swart; Yanli Wang; Nisa Ilgım Çelik; Anne Molitor; Vahid Ziaee; Nasim Movahedi; Mohammad Shahrooei; Nima Parvaneh; Nasrin Alipour-olyei; Raphael Carapito; Qin Xu; Silvia Preite; David Beck; Jae Jin Chae; Michele Nehrebecky; Amanda K. Ombrello; Patrycja Hoffmann; Tina Romeo; Natalie Deuitch; Brynja Matthíasardóttir; James C Mullikin; Hirsh Komarow; Jennifer Stoddard; Julie Niemela; Kerry Dobbs; Colin L. Sweeney; Holly Anderton; Kate Lawlor; Hiroyuki; Dan Yang; Manfred Boehm; Jeremy Davis; Pamela Mudd; Davide Randazzo; Wanxia Li Tsai; Massimo Gadina; Mariana Kaplan; Junya Toguchida; Christian T. Mayer; Sergio D. Rosenzweig; Luigi Notarangelo; Kazuhiro Iwai

  Nature Immunology, May 2024

  
• HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection

  Victoria L Hartley; Arwa M Qaqish; Matthew J Wood; Brian T Studnicka; Kazuhiro Iwai; Ta-Chiang Liu; Donna A MacDuff

  The Journal of Immunology, 15 Dec. 2023

  
• PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.

  Hiroaki Fujita; Yu-Ki Tanaka; Seiryo Ogata; Noriyuki Suzuki; Sota Kuno; Uladzimir Barayeu; Takaaki Akaike; Yasumitsu Ogra; Kazuhiro Iwai

  Nature structural & molecular biology, 12 Jun. 2024

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• Myofiber-type-dependent 'boulder' or 'multitudinous pebble' formations across distinct amylopectinoses.

  Sharmistha Mitra; Baozhi Chen; John M Shelton; Silvia Nitschke; Jun Wu; Lindsay Covington; Mathew Dear; Tori Lynn; Mayank Verma; Felix Nitschke; Yasuhiro Fuseya; Kazuhiro Iwai; Bret M Evers; Berge A Minassian

  Acta neuropathologica, 27 Feb. 2024

  
• Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling

  Yasuhiro Fuseya; Keiichiro Kadoba; Xiaoxi Liu; Hiroyuki Suetsugu; Takeshi Iwasaki; Koichiro Ohmura; Takayuki Sumida; Yuta Kochi; Akio Morinobu; Chikashi Terao; Kazuhiro Iwai

  JCI Insight, 08 Feb. 2024

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• A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.

  Yukiko Takeda; Masahiro Ueki; Junpei Matsuhiro; Erik Walinda; Takayuki Tanaka; Masafumi Yamada; Hiroaki Fujita; Shunichiro Takezaki; Ichiro Kobayashi; Sakura Tamaki; Sanae Nagata; Noriko Miyake; Naomichi Matsumoto; Mitsujiro Osawa; Takahiro Yasumi; Toshio Heike; Fumiaki Ohtake; Megumu K Saito; Junya Toguchida; Junko Takita; Tadashi Ariga; Kazuhiro Iwai

  The Journal of experimental medicine, 03 Jun. 2024

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• HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes.

  Kentaro Akagi; Shiro Baba; Hiroaki Fujita; Yasuhiro Fuseya; Daisuke Yoshinaga; Hirohito Kubota; Eitaro Kume; Fumiaki Fukumura; Koichi Matsuda; Takayuki Tanaka; Takuya Hirata; Megumu K Saito; Kazuhiro Iwai; Junko Takita

  Scientific reports, 17 Apr. 2024

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• Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity

  Erik Walinda; Kenji Sugase; Naoki Ishii; Masahiro Shirakawa; Kazuhiro Iwai; Daichi Morimoto

  Journal of Biological Chemistry, Aug. 2023

  
• Oxygen modulates iron homeostasis by switching iron-sensing of NCOA4

  Sota Kuno; Kazuhiro Iwai

  Journal of Biological Chemistry, Apr. 2023

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• Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion

  Katsuhiro Sasaki; Yoshie Hayamizu; Ryuji Murakami; Masakazu Toi; Kazuhiro Iwai

  FEBS Letters, 15 Apr. 2023

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• Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5

  Keito Hiragi; Akira Nishide; Kenji Takagi; Kazuhiro Iwai; Minsoo Kim; Tsunehiro Mizushima

  The Journal of Biochemistry, 04 Jan. 2023

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• Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation.

  Yusuke Sakamoto; Katsuhiro Sasaki; Mayuki Omatsu; Kensuke Hamada; Yuki Nakanishi; Yoshiro Itatani; Kenji Kawada; Kazutaka Obama; Hiroshi Seno; Kazuhiro Iwai

  The Journal of pathology, 01 Dec. 2022

  
• Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia.

  Koji Jimbo; Ayuna Hattori; Shuhei Koide; Takahiro Ito; Katsuhiro Sasaki; Kazuhiro Iwai; Yasuhito Nannya; Atsushi Iwama; Arinobu Tojo; Takaaki Konuma

  Leukemia, 09 Nov. 2022

  
• Role of linear ubiquitination in inflammatory responses and tissue homeostasis

  Katsuhiro Sasaki; Kazuhiro Iwai

  International Immunology, 23 Sep. 2022

  
• 3P104 Spectroscopic Characterization of Heme Coordination Structure in Iron Regulatory Protein 2 (IRP2)

  Endo R.; Ishikawa H.; Uchida T.; Kobayashi K.; Kitagawa T.; Iwai K.; Ishimori K.

  Seibutsu Butsuri, 2005

  
• 3P081 Heme Binding in Iron Response Regulator (Irr) and its Regulation Mechanism

  Nakagaki M.; Uchida T.; Kobayashi K.; Ishikawa H.; Kitagawa H.; Iwai K.; O'Brian Mark; Ishimori K.

  Seibutsu Butsuri, 2005

  
• アレルギーやガンに関わるNF-κBの新しい活性化機構の発見 : 新規ユビキチン修飾, 直鎖状ポリユビキチン化によるNF-κB活性化

  岩井 一宏; 坂田 真一; 中川 朋子; 徳永 文稔

  化学と生物, 01 Sep. 2009

  
• Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase

  Yasuhiro Fuseya; Kazuhiro Iwai

  Cells, Oct. 2021, Peer-reviewed

  
• 2P062 Heme Binding Affinity of Iron Response Regulator (Irr) and its Regulation Mechanism

  Nakagaki M.; Bamba A.; Ishikawa H.; Iwai K.; O'Brian Mark; Morishima I.; Is K.

  Seibutsu Butsuri, 2004

  
• 2P063 Spectroscopic Characterization of Heme Binding and Coordination Structure in Iron Regulatory Protein 2(IRP2)

  Endo R.; Ishikawa H.; Iwai K.; Morishima I.; Ishimori K.

  Seibutsu Butsuri, 2004

  
• Functional difference between IRE-recongnation and IRE-binding sites in IRPs

  Watanabe K.; Ishikawa H.; Iwai K.; Ishimori K.; Morishima I.

  Seibutsu Butsuri, 2001

  
• Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis.

  Sota Kuno; Hiroaki Fujita; Yu-Ki Tanaka; Yasumitsu Ogra; Kazuhiro Iwai

  EMBO reports, 04 May 2022

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• ABIN1 is a signal-induced autophagy receptor that attenuates NF-κB activation by recognizing linear ubiquitin chains.

  Yutaka Shinkawa; Koshi Imami; Yasuhiro Fuseya; Katsuhiro Sasaki; Koichiro Ohmura; Yasushi Ishihama; Akio Morinobu; Kazuhiro Iwai

  FEBS letters, 25 Feb. 2022

  
• Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures.

  Erik Walinda; Daichi Morimoto; Tomoki Sorada; Kazuhiro Iwai; Kenji Sugase

  Protein expression and purification, Nov. 2021

  
• Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.

  Yukiko Yoshida; Makoto Asahina; Arisa Murakami; Junko Kawawaki; Meari Yoshida; Reiko Fujinawa; Kazuhiro Iwai; Ryuichi Tozawa; Noriyuki Matsuda; Keiji Tanaka; Tadashi Suzuki

  Proceedings of the National Academy of Sciences of the United States of America, 06 Jul. 2021

  
• Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility

  Daichi Morimoto; Erik Walinda; Shingo Takashima; Mayu Nishizawa; Kazuhiro Iwai; Masahiro Shirakawa; Kenji Sugase

  BIOCHEMISTRY, Mar. 2021

  
• Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death

  Kazuhiro Iwai

  The FEBS Journal, 16 Feb. 2021

  
• The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.

  Yasuhiro Fuseya; Hiroaki Fujita; Minsoo Kim; Fumiaki Ohtake; Akira Nishide; Katsuhiro Sasaki; Yasushi Saeki; Keiji Tanaka; Ryosuke Takahashi; Kazuhiro Iwai

  Nature cell biology, Jun. 2020, Peer-reviewed

  
• LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic stress.

  Tomoyasu Jo; Momoko Nishikori; Yasunori Kogure; Hiroshi Arima; Katsuhiro Sasaki; Yoshiteru Sasaki; Tomoko Nakagawa; Fumie Iwai; Shuji Momose; Aki Shiraishi; Hiroshi Kiyonari; Noritaka Kagaya; Tetsuo Onuki; Kazuo Shin-Ya; Minoru Yoshida; Keisuke Kataoka; Seishi Ogawa; Kazuhiro Iwai; Akifumi Takaori-Kondo

  Blood, 23 Apr. 2020, Peer-reviewed

  
• Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

  Patricia L. Brazee; Luisa Morales-Nebreda; Natalia D. Magnani; Joe G.N. Garcia; Alexander V. Misharin; Karen M. Ridge; G.R. Scott Budinger; Kazuhiro Iwai; Laura A. Dada; Jacob I. Sznajder

  Journal of Clinical Investigation, 27 Jan. 2020, Peer-reviewed

  
• Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance

  Yudai Nishitani; Hirotaka Okutani; Yukiko Takeda; Takeshi Uchida; Kazuhiro Iwai; Koichiro Ishimori

  Journal of Inorganic Biochemistry, Sep. 2019, Peer-reviewed

  
• Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.

  Katsuhiro Sasaki; Ai Himeno; Tomoko Nakagawa; Yoshiteru Sasaki; Hiroshi Kiyonari; Kazuhiro Iwai

  Nature communications, 28 Aug. 2019, Peer-reviewed

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• Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCF^FBXL5 ubiquitin ligase

  Iwai, K.

  Free Radical Biology and Medicine, Mar. 2019, Peer-reviewed, Invited

  
• LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

  Kazuhiro Iwai

  Nature Communications, Dec. 2019, Peer-reviewed

  
• NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin

  Naoki Ishii; Erik Walinda; Naoto Iwakawa; Daichi Morimoto; Kazuhiro Iwai; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR Assignments, Apr. 2019, Peer-reviewed

  
• HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection

  Kazuhiro Iwai

  Journal of Virology, 12 Sep. 2018, Peer-reviewed

  
• Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins

  Mariko Ogura; Ryosuke Endo; Haruto Ishikawa; Yukiko Takeda; Takeshi Uchida; Kazuhiro Iwai; Kazuo Kobayashi; Koichiro Ishimori

  Journal of Inorganic Biochemistry, 01 May 2018, Peer-reviewed

  
• Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

  Hiroaki Fujita; Akira Tokunaga; Satoshi Shimizu; Amanda L. Whiting; Francisco Aguilar-Alonso; Kenji Takagi; Erik Walinda; Yoshiteru Sasaki; Taketo Shimokawa; Tsunehiro Mizushima; Izuru Ohki; Mariko Ariyoshi; Hidehito Tochio; Federico Bernal; Masahiro Shirakawa; Kazuhiro Iwai

  Cell Reports, 24 Apr. 2018, Peer-reviewed

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• Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development.

  Sasaki, Y; Iwai, K

  J. Immunol., Apr. 2018, Peer-reviewed

  
• Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

  Seiji Kaji; Takakuni Maki; Hisanori Kinoshita; Norihito Uemura; Takashi Ayaki; Yasuhiro Kawamoto; Takahiro Furuta; Makoto Urushitani; Masato Hasegawa; Yusuke Kinoshita; Yuichi Ono; Xiaobo Mao; Tran H. Quach; Kazuhiro Iwai; Valina L. Dawson; Ted M. Dawson; Ryosuke Takahashi

  Stem Cell Reports, 13 Feb. 2018, Peer-reviewed

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• SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth

  Hironari Tamiya; Hyungsoo Kim; Oleksiy Klymenko; Heejung Kim; Yongmei Feng; Tongwu Zhang; Ji Yun Han; Ayako Murao; Scott J. Snipas; Lucia Jilaveanu; Kevin Brown; Harriet Kluger; Hao Zhang; Kazuhiro Iwai; Zeev A. Ronai

  Journal of Clinical Investigation, 02 Jan. 2018, Peer-reviewed

  
• SCFFBXO27による損傷リソソームから細胞質へ露出した糖蛋白質のユビキチン化はリソファジーの引き金となる

  吉田 雪子; 安田 さや香; 藤田 敏治; 濱崎 万穂; 村上 有沙; 川脇 純子; 岩井 一宏; 佐伯 泰; 吉森 保; 松田 憲之; 田中 啓二

  生命科学系学会合同年次大会, Dec. 2017

  
• HIF and HOIL-1L-mediated PKC zeta degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury

  Natalia D. Magnani; Laura A. Dada; Markus A. Queisser; Patricia L. Brazee; Lynn C. Welch; Kishore R. Anekalla; Guofei Zhou; Olga Vagin; Alexander V. Misharin; G. R. Scott Budinger; Kazuhiro Iwai; Aaron J. Ciechanover; Jacob I. Sznajder

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2017, Peer-reviewed

  
• Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy

  Yukiko Yoshida; Sayaka Yasuda; Toshiharu Fujita; Maho Hamasaki; Arisa Murakami; Junko Kawawaki; Kazuhiro Iwai; Yasushi Saeki; Tamotsu Yoshimori; Noriyuki Matsuda; Keiji Tanaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2017, Peer-reviewed

  
• HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63-and Met1-Linked Hybrid Polyubiquitin Chains

  Yuri Shibata; Fuminori Tokunaga; Eiji Goto; Ginga Komatsu; Jin Gohda; Yasushi Saeki; Keiji Tanaka; Hirotaka Takahashi; Tatsuya Sawasaki; Satoshi Inoue; Hiroyuki Oshiumi; Tsukasa Seya; Hiroyasu Nakano; Yuetsu Tanaka; Kazuhiro Iwai; Jun-ichiro Inoue

  PLOS PATHOGENS, Jan. 2017, Peer-reviewed

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• Survival of mature T cells depends on signaling through HOIP

  Kazumi Okamura; Akiko Kitamura; Yoshiteru Sasaki; Doo Hyun Chung; Shoji Kagami; Kazuhiro Iwai; Koji Yasutomo

  SCIENTIFIC REPORTS, Oct. 2016, Peer-reviewed

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• Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles

  Emi Yamano; Masahiro Sugimoto; Akiyoshi Hirayama; Satoshi Kume; Masanori Yamato; Guanghua Jin; Seiki Tajima; Nobuhito Goda; Kazuhiro Iwai; Sanae Fukuda; Kouzi Yamaguti; Hirohiko Kuratsune; Tomoyoshi Soga; Yasuyoshi Watanabe; Yosky Kataoka

  SCIENTIFIC REPORTS, Oct. 2016, Peer-reviewed

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• Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

  Seshiru Nakazawa; Daisuke Oikawa; Ryohei Ishii; Takashi Ayaki; Hirotaka Takahashi; Hiroyuki Takeda; Ryuichiro Ishitani; Kiyoko Kamei; Izumi Takeyoshi; Hideshi Kawakami; Kazuhiro Iwai; Izuho Hatada; Tatsuya Sawasaki; Hidefumi Ito; Osamu Nureki; Fuminori Tokunaga

  NATURE COMMUNICATIONS, Aug. 2016, Peer-reviewed

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• Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein

  Kazuo Kobayashi; Megumi Nakagaki; Haruto Ishikawa; Kazuhiro Iwai; Mark R. O'Brian; Koichiro Ishimori

  BIOCHEMISTRY, Jul. 2016, Peer-reviewed

  
• Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection

  Satoshi Shimizu; Hiroaki Fujita; Yoshiteru Sasaki; Tatsuaki Tsuruyama; Kazuhiko Fukuda; Kazuhiro Iwai

  MOLECULAR AND CELLULAR BIOLOGY, May 2016, Peer-reviewed

  
• Roles of the NF-kappa B Pathway in B-Lymphocyte Biology

  Yoshiteru Sasaki; Kazuhiro Iwai

  B CELL RECEPTOR SIGNALING, 2016, Peer-reviewed, Invited

  
• Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex

  Daisuke Morita; Yukie Yamamoto; Tatsuaki Mizutani; Takeshi Ishikawa; Juri Suzuki; Tatsuhiko Igarashi; Naoki Mori; Takashi Shiina; Hidetoshi Inoko; Hiroaki Fujita; Kazuhiro Iwai; Yoshimasa Tanaka; Bunzo Mikami; Masahiko Sugita

  NATURE COMMUNICATIONS, Jan. 2016, Peer-reviewed

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• Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator

  Chihiro Kitatsuji; Kozue Izumi; Shusuke Nambu; Masaki Kurogochi; Takeshi Uchida; Shin-Ichiro Nishimura; Kazuhiro Iwai; Mark R. O'Brian; Masao Ikeda-Saito; Koichiro Ishimori

  SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed

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• Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

  James Bowman; Mary A. Rodgers; Mude Shi; Rina Amatya; Bruce Hostager; Kazuhiro Iwai; Shou-Jiang Gao; Jae U. Jung

  MBIO, Nov. 2015, Peer-reviewed

  
• The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3

  Taichi Kumanomidou; Kazuya Nishio; Kenji Takagi; Tomomi Nakagawa; Atsuo Suzuki; Takashi Yamane; Fuminori Tokunaga; Kazuhiro Iwai; Arisa Murakami; Yukiko Yoshida; Keiji Tanaka; Tsunehiro Mizushima

  PLOS ONE, Oct. 2015, Peer-reviewed

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• CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis

  Yongge Zhao; Chi A. Ma; Liming Wu; Kazuhiro Iwai; Jonathan D. Ashwell; Eugene M. Oltz; Dean W. Ballard; Ashish Jain

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2015, Peer-reviewed

  
• Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.

  Katsuhiro Sasaki; Kazuhiro Iwai

  Immunological reviews, Jul. 2015, Peer-reviewed, Invited

  
• Potential biomarkers of fatigue identified by plasma metabolome analysis in rats

  Satoshi Kume; Masanori Yamato; Yasuhisa Tamura; Guanghua Jin; Masayuki Nakano; Yukiharu Miyashige; Asami Eguchi; Yoshiyuki Ogata; Nobuhito Goda; Kazuhiro Iwai; Emi Yamano; Yasuyoshi Watanabe; Tomoyoshi Soga; Yosky Kataoka

  PLoS ONE, 20 Mar. 2015, Peer-reviewed

  
• Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

  Hiroki Sakamoto; Shinichiro Egashira; Nae Saito; Takayoshi Kirisako; Simon Miller; Yoshiteru Sasaki; Tadahiko Matsumoto; Manabu Shimonishi; Toru Komatsu; Takuya Terai; Tasuku Ueno; Kenjiro Hanaoka; Hirotatsu Kojima; Takayoshi Okabe; Soichi Wakatsuki; Kazuhiro Iwai; Tetsuo Nagano

  ACS chemical biology, 20 Mar. 2015, Peer-reviewed

  
• Possible involvement of iron-induced oxidative insults in neurodegeneration

  Takeshi Asano; Masato Koike; Shin-ichi Sakata; Yukiko Takeda; Tomoko Nakagawa; Taku Hatano; Satoshi Ohashi; Manabu Funayama; Kenji Yoshimi; Masato Asanuma; Shinya Toyokuni; Hideki Mochizuki; Yasuo Uchiyama; Nobutaka Hattori; Kazuhiro Iwai

  NEUROSCIENCE LETTERS, Feb. 2015, Peer-reviewed

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• LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

  Yasuka Matsunaga; Yusuke Nakatsu; Toshiaki Fukushima; Hirofumi Okubo; Misaki Iwashita; Hideyuki Sakoda; Midori Fujishiro; Takeshi Yamamotoya; Akifumi Kushiyama; Shin-ichiro Takahashi; Yoshihiro Tsuchiya; Hideaki Kamata; Fuminori Tokunaga; Kazuhiro Iwai; Tomoichiro Asano

  MEDIATORS OF INFLAMMATION, 2015, Peer-reviewed

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• Immunoblot Analysis of Linear Polyubiquitination of NEMO

  Sasaki, Y.; Fujita, H.; Nakai, M.; Iwai, K.

  Methods in Molecular Biology, 2015, Peer-reviewed

  
• Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

  Donna A. MacDuff; Tiffany A. Reese; Jacqueline M. Kimmey; Leslie A. Weiss; Christina Song; Xin Zhang; Amal Kambal; Erning Duan; Javier A. Carrero; Bertrand Boisson; Emmanuel Laplantine; Alain Israel; Capucine Picard; Marco Colonna; Brian T. Edelson; L. David Sibley; Christina L. Stallings; Jean-Laurent Casanova; Kazuhiro Iwai; Herbert W. Virgin

  ELIFE, Jan. 2015, Peer-reviewed

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• The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

  Daichi Morimoto; Erik Walinda; Harumi Fukada; Yu-Shin Sou; Shun Kageyama; Masaru Hoshino; Takashi Fujii; Hikaru Tsuchiya; Yasushi Saeki; Kyohei Arita; Mariko Ariyoshi; Hidehito Tochio; Kazuhiro Iwai; Keiichi Namba; Masaaki Komatsu; Keiji Tanaka; Masahiro Shirakawa

  Nature Communications, Jan. 2015, Peer-reviewed

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• Ubiquitin Chain Elongation: An Intriguing Strategy

  Kazuhiro Iwai; Keiji Tanaka

  MOLECULAR CELL, Oct. 2014, Invited

  
• HOIL-1L Functions as the PKC zeta Ubiquitin Ligase to Promote Lung Tumor Growth

  Markus A. Queisser; Laura A. Dada; Nimrod Deiss-Yehiely; Martin Angulo; Guofei Zhou; Fotini M. Kouri; Lawrence M. Knab; Jing Liu; Alexander H. Stegh; Malcolm M. DeCamp; G. R. Scott Budinger; Navdeep S. Chandel; Aaron Ciechanover; Kazuhiro Lwai; Jacob I. Sznajder

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Sep. 2014, Peer-reviewed

  
• Linear ubiquitin chains: NF-kappa B signalling, cell death and beyond

  Kazuhiro Iwai; Hiroaki Fujita; Yoshiteru Sasaki

  NATURE REVIEWS MOLECULAR CELL BIOLOGY, Aug. 2014, Peer-reviewed, Invited

  
• The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

  Mary A. Rodgers; James W. Bowman; Hiroaki Fujita; Nicole Orazio; Mude Shi; Qiming Liang; Rina Amatya; Thomas J. Kelly; Kazuhiro Iwai; Jenny Ting; Jae U. Jung

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2014, Peer-reviewed

  
• Mechanism Underlying I kappa B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex

  Hiroaki Fujita; Simin Rahighi; Mariko Akita; Ryuichi Kato; Yoshiteru Sasaki; Soichi Wakatsuki; Kazuhiro Iwai

  MOLECULAR AND CELLULAR BIOLOGY, Apr. 2014, Peer-reviewed

  
• IFN-gamma or IFN-alpha Ameliorates Chronic Proliferative Dermatitis by Inducing Expression of Linear Ubiquitin Chain Assembly Complex

  Hironari Tamiya; Mika Terao; Tsuyoshi Takiuchi; Masaki Nakahara; Yoshiteru Sasaki; Ichiro Katayama; Hideki Yoshikawa; Kazuhiro Iwai

  JOURNAL OF IMMUNOLOGY, Apr. 2014, Peer-reviewed

  
• Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

  Yibin Yang; Roland Schmitz; Joseph Mitala; Amanda Whiting; Wenming Xiao; Michele Ceribelli; George W. Wright; Hong Zhao; Yandan Yang; Weihong Xu; Andreas Rosenwald; German Ott; Randy D. Gascoyne; Joseph M. Connors; Lisa M. Rimsza; Elias Campo; Elaine S. Jaffe; Jan Delabie; Erlend B. Smeland; Rita M. Braziel; Raymond R. Tubbs; James R. Cook; Dennis D. Weisenburger; Wing C. Chan; Adrian Wiestner; Michael J. Kruhlak; Kazuhiro Iwai; Federico Bernal; Louis M. Staudt

  CANCER DISCOVERY, Apr. 2014, Peer-reviewed

  
• Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

  Tsuyoshi Takiuchi; Tomoko Nakagawa; Hironari Tamiya; Hiroaki Fujita; Yoshiteru Sasaki; Yasushi Saeki; Hiroyuki Takeda; Tatsuya Sawasaki; Alexander Buchberger; Tadashi Kimura; Kazuhiro Iwai

  GENES TO CELLS, Mar. 2014, Peer-reviewed

  
• Diverse roles of the ubiquitin system in NF-kappa B activation

  Kazuhiro Iwai

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Jan. 2014, Peer-reviewed

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• Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

  Naonobu Fujita; Eiji Morita; Takashi Itoh; Atsushi Tanaka; Megumi Nakaoka; Yuki Osada; Tetsuo Umemoto; Tatsuya Saitoh; Hitoshi Nakatogawa; Shouhei Kobayashi; Tokuko Haraguchi; Jun-Lin Guan; Kazuhiro Iwai; Fuminori Tokunaga; Kazunobu Saito; Koutaro Ishibashi; Shizuo Akira; Mitsunori Fukuda; Takeshi Noda; Tamotsu Yoshimori

  JOURNAL OF CELL BIOLOGY, Oct. 2013, Peer-reviewed

  
• Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells

  Yoshiteru Sasaki; Soichi Sano; Masaki Nakahara; Shigeo Murata; Kohei Kometani; Yuichi Aiba; Shinji Sakamoto; Yoshihiro Watanabe; Keiji Tanaka; Tomohiro Kurosaki; Kazuhiro Iwai

  EMBO Journal, 11 Sep. 2013, Peer-reviewed

  
• IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway

  Mineaki Seki; Yukiko Takeda; Kazuhiro Iwai; Kiyoji Tanaka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2013, Peer-reviewed

  
• Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed I kappa B Kinase Activation

  Ken Blackwell; Laiqun Zhang; Lauren M. Workman; Adrian T. Ting; Kazuhiro Iwai; Hasem Habelhah

  MOLECULAR AND CELLULAR BIOLOGY, May 2013, Peer-reviewed

  
• Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters Is an Initial Event in Iron-Dependent Gene Suppression

  Ryo Ueta; Naoko Fujiwara; Kazuhiro Iwai; Yuko Yamaguchi-Iwai

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2012, Peer-reviewed

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• Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappa B regulation

  Fuminori Tokunaga; Hiroshi Nishimasu; Ryuichiro Ishitani; Eiji Goto; Takuya Noguchi; Kazuhiro Mio; Kiyoko Kamei; Averil Ma; Kazuhiro Iwai; Osamu Nureki

  EMBO JOURNAL, Oct. 2012, Peer-reviewed

  
• Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.

  Yoshinori Uekusa; Syunsuke Mimura; Hiroaki Sasakawa; Eiji Kurimoto; Eri Sakata; Serve Olivier; Hirokazu Yagi; Fuminori Tokunaga; Kazuhiro Iwai; Koichi Kato

  Biomolecular NMR assignments, Oct. 2012, Peer-reviewed

  
• Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex

  S. Mehdi Belgnaoui; Suzanne Paz; Sara Samuel; Marie-Line Goulet; Qiang Sun; Marjolein Kikkert; Kazuhiro Iwai; Ivan Dikic; John Hiscott; Rongtuan Lin

  CELL HOST & MICROBE, Aug. 2012, Peer-reviewed

  
• Linear ubiquitination: A novel NF-kappa B regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex

  Fuminori Tokunaga; Kazuhiro Iwai

  ENDOCRINE JOURNAL, Aug. 2012, Peer-reviewed

  
• LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

  Fuminori Tokunaga; Kazuhiro Iwai

  MICROBES AND INFECTION, Jul. 2012, Peer-reviewed

  
• Diverse ubiquitin signaling in NF-kappa B activation

  Kazuhiro Iwai

  TRENDS IN CELL BIOLOGY, Jul. 2012, Peer-reviewed

  
• Analysis of Nuclear Factor-kappa B (NF-kappa B) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-kappa B

  Tobias Kensche; Fuminori Tokunaga; Fumiyo Ikeda; Eiji Goto; Kazuhiro Iwai; Ivan Dikic

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2012, Peer-reviewed

  
• A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.

  Hirokazu Yagi; Kazuhiro Ishimoto; Takeshi Hiromoto; Hiroaki Fujita; Tsunehiro Mizushima; Yoshinori Uekusa; Maho Yagi-Utsumi; Eiji Kurimoto; Masanori Noda; Susumu Uchiyama; Fuminori Tokunaga; Kazuhiro Iwai; Koichi Kato

  EMBO reports, 01 May 2012, Peer-reviewed

  
• Generation and physiological roles of linear ubiquitin chains

  Henning Walczak; Kazuhiro Iwai; Ivan Dikic

  BMC BIOLOGY, Mar. 2012, Peer-reviewed

  
• Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells

  Masato Tomonaga; Nobuyuki Hashimoto; Fuminori Tokunaga; Megumi Onishi; Akira Myoui; Hideki Yoshikawa; Kazuhiro Iwai

  INTERNATIONAL JOURNAL OF ONCOLOGY, Feb. 2012, Peer-reviewed

  
• Synthesis and analysis of linear ubiquitin chains.

  Iwai, K.

  Methods in molecular biology (Clifton, N.J.), 2012, Peer-reviewed

  
• Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

  Yusuke Sato; Hiroaki Fujita; Azusa Yoshikawa; Masami Yamashita; Atsushi Yamagata; Stephen E. Kaiser; Kazuhiro Iwai; Shuya Fukai

  Proceedings of the National Academy of Sciences of the United States of America, 20 Dec. 2011, Peer-reviewed

  
• LUBAC regulates NF-kappa B activation upon genotoxic stress by promoting linear ubiquitination of NEMO

  Jixiao Niu; Yuling Shi; Kazuhiro Iwai; Zhao-Hui Wu

  EMBO JOURNAL, Sep. 2011, Peer-reviewed

  
• The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo

  Toshiro Moroishi; Masaaki Nishiyama; Yukiko Takeda; Kazuhiro Iwai; Keiichi I. Nakayama

  CELL METABOLISM, Sep. 2011, Peer-reviewed

  
• Linear polyubiquitin chains A new modifier involved in NF kappa B activation and chronic inflammation including dermatitis

  Kazuhiro Iwai

  CELL CYCLE, Sep. 2011, Peer-reviewed

  
• A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction

  Masaki Takatsuka; Mayuko Osada-Oka; Eisuke F. Satoh; Kengo Kitadokoro; Yukiko Nishiuchi; Mamiko Niki; Masayasu Inoue; Kazuhiro Iwai; Tetsuo Arakawa; Yoshihiro Shimoji; Hisashi Ogura; Kazuo Kobayashi; Anura Rambukkana; Sohkichi Matsumoto

  PLOS ONE, Jun. 2011, Peer-reviewed

  
• Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

  Takeshi Asano; Masaaki Komatsu; Yuko Yamaguchi-Iwai; Fuyuki Ishikawa; Noboru Mizushima; Kazuhiro Iwai

  MOLECULAR AND CELLULAR BIOLOGY, May 2011, Peer-reviewed

  
• SHARPIN is a component of the NF-kappa B-activating linear ubiquitin chain assembly complex

  Fuminori Tokunaga; Tomoko Nakagawa; Masaki Nakahara; Yasushi Saeki; Masami Taniguchi; Shin-ichi Sakata; Keiji Tanaka; Hiroyasu Nakano; Kazuhiro Iwai

  NATURE, Mar. 2011, Peer-reviewed

  
• SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappa B activity and apoptosis

  Fumiyo Ikeda; Yonathan Lissanu Deribe; Sigrid S. Skanland; Benjamin Stieglitz; Caroline Grabbe; Mirita Franz-Wachtel; Sjoerd J. L. van Wijk; Panchali Goswami; Vanja Nagy; Janos Terzic; Fuminori Tokunaga; Ariadne Androulidaki; Tomoko Nakagawa; Manolis Pasparakis; Kazuhiro Iwai; John P. Sundberg; Liliana Schaefer; Katrin Rittinger; Boris Macek; Ivan Dikic

  NATURE, Mar. 2011, Peer-reviewed

  
• Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif

  Haruto Ishikawa; Megumi Nakagaki; Ai Bamba; Takeshi Uchida; Hiroshi Hori; Mark R. O'Brian; Kazuhiro Iwai; Koichiro Ishimori

  BIOCHEMISTRY, Feb. 2011, Peer-reviewed

  
• Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

  Kyung-Soo Inn; Michaela U. Gack; Fuminori Tokunaga; Mude Shi; Lai-Yee Wong; Kazuhiro Iwai; Jae U. Jung

  MOLECULAR CELL, Feb. 2011, Peer-reviewed

  
• RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway

  Kana Shimada; Makio Saeki; Hiroshi Egusa; Sho Fukuyasu; Yoshiaki Yura; Kazuhiro Iwai; Yoshinori Kamisaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2011, Peer-reviewed

  
• The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1

  Hanako Morikawa; Minsoo Kim; Hitomi Mimuro; Claire Punginelli; Tomohiro Koyama; Shinya Nagai; Atsushi Miyawaki; Kazuhiro Iwai; Chihiro Sasakawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2010, Peer-reviewed

  
• Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex

  Taichi Kumanomidou; Tomomi Nakagawa; Tsunehiro Mizushima; Atsuo Suzuki; Fuminori Tokunaga; Kazuhiro Iwai; Yukiko Yoshida; Keiji Tanaka; Takashi Yamane

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jan. 2010, Peer-reviewed

  
• Functions of linear ubiquitin chains in the NF-κB pathway: Linear polyubiquitin in NF-κB signaling

  Kazuhiro Iwai

  Sub-Cellular Biochemistry, 2010, Peer-reviewed

  
• Linear polyubiquitination: a new regulator of NF-kappa B activation

  Kazuhiro Iwai; Fuminori Tokunaga

  EMBO REPORTS, Jul. 2009, Peer-reviewed

  
• Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation

  Tokunaga, F.; Iwai, K.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Apr. 2009, Peer-reviewed

  
• Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation

  Kiyo-aki Ishii; Toshio Fumoto; Kazuhiro Iwai; Sunao Takeshita; Masako Ito; Nobuyuki Shimohata; Hiroyuki Aburatani; Shigeru Taketani; Christopher J. Lelliott; Antonio Vidal-Puig; Kyoji Ikeda

  NATURE MEDICINE, Mar. 2009, Peer-reviewed

  
• Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation

  Fuminori Tokunaga; Shin-ichi Sakata; Yasushi Saeki; Yoshinori Satomi; Takayoshi Kirisako; Kiyoko Kamei; Tomoko Nakagawa; Michiko Kato; Shigeo Murata; Shoji Yamaoka; Masahiro Yamamoto; Shizuo Akira; Toshifumi Takao; Keiji Tanaka; Kazuhiro Iwai

  NATURE CELL BIOLOGY, Feb. 2009, Peer-reviewed

  
• MDM2 is a novel E3 ligase for HIV-1 Vif

  Taisuke Izumi; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hiroaki Higashitsuji; Katsuhiko Itoh; Katsuhiro Io; Masashi Matsui; Kazuhiro Iwai; Hiroshi Kondoh; Toshihiro Sato; Mitsunori Tomonaga; Satoru Ikeda; Hirofumi Akari; Yoshio Koyanagi; Jun Fujita; Takashi Uchiyama

  RETROVIROLOGY, Jan. 2009, Peer-reviewed

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• Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (vol 455, pg 358, 2008)

  Yusuke Sato; Azusa Yoshikawa; Atsushi Yamagata; Hisatoshi Mimura; Masami Yamashita; Kayoko Ookata; Osamu Nureki; Kazuhiro Iwai; Masayuki Komada; Shuya Fukai

  NATURE, Nov. 2008, Peer-reviewed

  
• Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

  Yusuke Sato; Azusa Yoshikawa; Atsushi Yamagata; Hisatoshi Mimura; Masami Yamashita; Kayoko Ookata; Osamu Nureki; Kazuhiro Iwai; Masayuki Komada; Shuya Fukai

  NATURE, Sep. 2008, Peer-reviewed

  
• The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination

  Yasuhiro Miyauchi; Michiko Kato; Fuminori Tokunaga; Kazuhiro Iwai

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2008, Peer-reviewed

  
• Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein

  Guofei Zhou; Laura A. Dada; Navdeep S. Chandel; Kazuhiro Iwai; Emilia Lecuona; Aaron Ciechanover; Jacob I. Sznajder

  FASEB JOURNAL, May 2008, Peer-reviewed

  
• Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508

  Daisuke Morito; Kazuyoshi Hirao; Yukako Oda; Nobuko Hosokawa; Fuminori Tokunaga; Douglas M. Cyr; Keiji Tanaka; Kazuhiro Iwai; Kazuhiro Nagata

  MOLECULAR BIOLOGY OF THE CELL, Apr. 2008, Peer-reviewed

  
• Fbx8 makes Arf6 refractory to function via ubiquitination

  Hajime Yano; Itaru Kobayashi; Yasuhito Onodera; Frederic Luton; Michel Franco; Yuichi Mazaki; Shigeru Hashimoto; Kazuhiro Iwai; Ze'ev Ronai; Hisataka Sabe

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2008, Peer-reviewed

  
• Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target

  Nitzan Shabek; Kazuhiro Iwai; Aaron Ciechanover

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2007, Peer-reviewed

  
• Cerebral vascular accumulation of dutch-type A beta 42, but not wild-type A beta 42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type

  Kazuchika Nishitsuji; Takami Tomiyama; Kenichi Ishibashi; Fuyuki Kametani; Kazuharu Ozawa; Ryota Okada; Marion L. Maat-Schieman; Raymund A. C. Roos; Kazuhiro Iwai; Hiroshi Mori

  JOURNAL OF NEUROSCIENCE RESEARCH, Oct. 2007, Peer-reviewed

  
• Heme induces ubiquitination and degradation of the transcription factor bach1

  Yukari Zenke-Kawasaki; Yoshihiro Dohi; Yasutake Katoh; Tsuyoshi Ikura; Masae Ikura; Toshimasa Asahara; Furninori Tokunaga; Kazuhiro Iwai; Kazuhiko Igarashi

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 2007, Peer-reviewed

  
• Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae

  Ryo Ueta; Naoko Fujiwara; Kazuhiro Iwai; Yuko Yamaguchi-Iwai

  MOLECULAR BIOLOGY OF THE CELL, Aug. 2007, Peer-reviewed

  
• A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation

  Yukiko Yoshida; Arisa Murakami; Kazuhiro Iwai; Keiji Tanaka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2007, Peer-reviewed

  
• Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity

  Eri Sakata; Yoshiki Yamaguchi; Yasuhiro Miyauchi; Kazuhiro Iwai; Tomoki Chiba; Yasushi Saeki; Noriyuki Matsuda; Keiji Tanaka; Koichi Kato

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Feb. 2007, Peer-reviewed

  
• Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex

  Munehiro Nakamura; Fuminori Tokunaga; Shin-ichi Sakata; Kazuhiro Iwai

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2006, Peer-reviewed

  
• Chemoenzymatic ubiquitination of artificial substrates

  Olga N. Burchak; Michel Jaquinod; Claire Cottin; Laurent Mugherli; Kazuhiro Iwai; Francois Chatelain; Maxim Y. Balakirev

  CHEMBIOCHEM, Nov. 2006, Peer-reviewed

  
• A ubiquitin ligase complex assembles linear polyubiquitin chains

  Takayoshi Kirisako; Kiyoko Kamei; Shigeo Murata; Michiko Kato; Hiromi Fukumoto; Masato Kanie; Soichi Sano; Fuminori Tokunaga; Keiji Tanaka; Kazuhiro Iwai

  EMBO JOURNAL, Oct. 2006, Peer-reviewed

  
• The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

  J Bayle; S Lopez; K Iwai; P Dubreuil; P De Sepulveda

  FEBS LETTERS, May 2006, Peer-reviewed

  
• Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex

  K Shirakawa; A Takaori-Kondo; M Kobayashi; M Tomonaga; T Izumi; K Fukunaga; A Sasada; A Abudu; Y Miyauchi; H Akari; K Iwai; T Uchiyama

  VIROLOGY, Jan. 2006, Peer-reviewed

  
• Studies of the ubiquitin proteasome system.

  Lorick, K.L.; Yang, Y.; Jensen, J.P.; Iwai, K.; Weissman, A.M.

  Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], 2006, Peer-reviewed

  
• Mechanism underlying ubiquitination of iron regulatory protein 2 (IRP2)

  Iwai, K.; Ishikawa, H.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 2006, Peer-reviewed

  
• Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2

  H Ishikawa; M Kato; H Hori; K Ishimori; T Kirisako; F Tokunaga; K Iwai

  MOLECULAR CELL, Jul. 2005, Peer-reviewed

  
• Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex

  Y Megumi; Y Miyauchi; H Sakurai; H Nobeyama; K Lorick; E Nakamura; T Chiba; K Tanaka; AM Weissman; T Kirisako; O Ogawa; K Iwai

  GENES TO CELLS, Jul. 2005, Peer-reviewed

  
• Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function

  M Kobayashi; A Takaori-Kondo; Y Miyauchi; K Iwai; T Uchiyama

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2005, Peer-reviewed

  
• Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates

  Y Yoshida; E Adachi; K Fukiya; K Iwai; K Tanaka

  EMBO REPORTS, Mar. 2005, Peer-reviewed

  
• Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1

  K Iwai; H Ishikawa; T Kirisako

  UBIQUITIN AND PROTEIN DEGRADATION, PART A, 2005, Peer-reviewed

  
• Recent advance in the understanding of iron metabolism and its role on host defense

  Kyoko Hishikawa; Kazuhiro Iwai

  Japanese Journal of Clinical Immunology, 2005, Peer-reviewed

  
• Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (vol 9, pg 865, 2004)

  T Tenno; K Fujiwara; H Tochio; K Iwai; EH Morita; H Hayashi; S Murata; H Hiroaki; M Sato; K Tanaka; M Shirakawa

  GENES TO CELLS, Nov. 2004, Peer-reviewed

  
• Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains

  T Tenno; K Fujiwara; H Tochio; K Iwai; EH Morita; H Hayashi; S Murata; H Hiroaki; M Sato; K Tanaka; M Shirakawa

  GENES TO CELLS, Oct. 2004, Peer-reviewed

  
• Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer

  H Nobeyama; T Sumi; F Misugi; E Okamoto; K Hattori; Y Matsumoto; T Yasui; K Honda; K Iwai; O Ishiko

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Jul. 2004, Peer-reviewed

  
• The ubiquitin system: From basic mechanisms to the patient bed

  A Ciechanover; K Iwai

  IUBMB LIFE, Apr. 2004, Peer-reviewed

  
• Structural basis of sugar-recognizing ubiquitin ligase

  T Mizushima; T Hirao; Y Yoshida; SJ Lee; T Chiba; K Iwai; Y Yamaguchi; K Kato; T Tsukihara; K Tanaka

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Apr. 2004, Peer-reviewed

  
• Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

  EG Meyron-Holtz; MC Ghosh; K Iwai; T LaVaute; Brazzolotto, X; UV Berger; W Land; H Ollivierre-Wilson; A Grinberg; P Love; TA Rouault

  EMBO JOURNAL, Jan. 2004, Peer-reviewed

  
• Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains

  Y Yoshida; F Tokunaga; T Chiba; K Iwai; K Tanaka; T Tai

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2003, Peer-reviewed

  
• An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins

  K Iwai

  JOURNAL OF BIOCHEMISTRY, Aug. 2003, Peer-reviewed

  
• Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

  D Ishida; K Kometani; HL Yang; K Kakugawa; K Masuda; K Iwai; M Suzuki; S Itohara; T Nakahata; H Hiai; H Kawamoto; M Hattori; N Minato

  CANCER CELL, Jul. 2003, Peer-reviewed

  
• Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

  K Yamanaka; H Ishikawa; Y Megumi; F Tokunaga; M Kanie; TA Rouault; Morishima, I; N Minato; K Ishimori; K Iwai

  NATURE CELL BIOLOGY, Apr. 2003, Peer-reviewed

  
• Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2

  M Ashizuka; T Fukuda; T Nakamura; K Shirasuna; K Iwai; H Izumi; K Kohno; M Kuwano; T Uchiumi

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2002, Peer-reviewed

  
• E3 ubiquitin ligase that recognizes sugar chains

  Yukiko Yoshida; Tomoki Chiba; Fuminori Tokunaga; Hiroshi Kawasaki; Kazuhiro Iwai; Toshiaki Suzuki; Yukishige Ito; Koji Matsuoka; Minoru Yoshida; Keiji Tanaka; Tadashi Tai

  Nature, 25 Jul. 2002, Peer-reviewed

  
• The NEDD8 pathway is essential for SCF beta-TrCp-mediated ubiquitination and processing of the NF-kappa B precursor p105

  RE Amir; K Iwai; A Ciechanover

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed

  
• A RING finger protein praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Needin family protein, Dlxin-1

  A Sasaki; Y Masuda; K Iwai; K Ikeda; K Watanabe

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed

  
• The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C

  H Okuda; K Saitoh; S Hirai; K Iwai; Y Takaki; M Baba; N Minato; S Ohno; T Shuin

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2001, Peer-reviewed

  
• NEDD8 recruits E2-ubiquitin to SCF E3 ligase

  T Kawakami; T Chiba; T Suzuki; K Iwai; K Yamanaka; N Minato; H Suzuki; N Shimbara; Y Hidaka; F Osaka; M Omata; K Tanaka

  EMBO JOURNAL, Aug. 2001, Peer-reviewed

  
• Mechanisms of ubiquitin-mediated, limited processing of the NF-kappa B1 precursor protein p105

  A Ciechanover; H Gonen; B Bercovich; S Cohen; Fajerman, I; A Israel; F Mercurio; C Kahana; AL Schwartz; K Iwai; A Orian

  BIOCHIMIE, Mar. 2001, Peer-reviewed

  
• Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

  T LaVaute; S Smith; S Cooperman; K Iwai; W Land; E Meyron-Holtz; SK Drake; G Miller; M Abu-Asab; M Tsokos; R Switzer; A Grinberg; P Love; N Tresser; TA Rouault

  NATURE GENETICS, Feb. 2001, Peer-reviewed

  
• Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

  T Kamura; S Sato; K Iwai; M Czyzyk-Krzeska; RC Conaway; JW Conaway

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2000, Peer-reviewed

  
• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  H Shimura; N Hattori; S Kubo; Y Mizuno; S Asakawa; S Minoshima; N Shimizu; K Iwai; T Chiba; K Tanaka; T Suzuki

  NATURE GENETICS, Jul. 2000, Peer-reviewed

  
• SCF beta-TrcP ubiquitin ligase-mediated processing of NF-kappa B p105 requires phosphorylation of its C-terminus by I kappa B kinase

  A Orian; H Gonen; B Bercovich; Fajerman, I; E Eytan; A Israel; F Mercurio; K Iwai; AL Schwartz; A Ciechanover

  EMBO JOURNAL, Jun. 2000, Peer-reviewed

  
• Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system

  E Sadot; Simcha, I; K Iwai; A Ciechanover; B Geiger; A Ben-Ze'ev

  ONCOGENE, Apr. 2000, Peer-reviewed

  
• Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

  G Levkowitz; H Waterman; SA Ettenberg; M Katz; AY Tsygankov; Alroy, I; S Lavi; K Iwai; Y Reiss; A Ciechanover; S Lipkowitz; Y Yarden

  MOLECULAR CELL, Dec. 1999, Peer-reviewed

  
• Stabilization of iron regulatory protein 2, IRP2, by aluminum

  Koji Yamanaka; Nagahiro Minato; Kazuhiro Iwai

  FEBS Letters, 26 Nov. 1999, Peer-reviewed

  
• Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of I kappa B alpha

  H Gonen; B Bercovich; A Orian; A Carrano; C Takizawa; K Yamanaka; M Pagano; K Iwai; A Ciechanover

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1999, Peer-reviewed

  
• 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer

  E Nakamura; M Sato; HL Yang; F Miyagawa; M Harasaki; K Tomita; S Matsuoka; A Noma; K Iwai; N Minato

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1999, Peer-reviewed

  
• Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product

  H Kurachi; Y Wada; N Tsukamoto; M Maeda; H Kubota; M Hattori; K Iwai; N Minato

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1997, Peer-reviewed

  
• Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human

  Y Wada; H Kubota; M Maeda; M Taniwaki; M Hattori; S Imamura; K Iwai; N Minato

  GENOMICS, Jan. 1997, Peer-reviewed

  
• Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase

  HY Kim; T LaVaute; K Iwai; RD Klausner; TA Rouault

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1996, Peer-reviewed

  
• Differences in the RNA binding sites of iron regulatory proteins and potential target diversity

  J Butt; HY Kim; JP Basilion; S Cohen; K Iwai; CC Philpott; S Altschul; RD Klausner; TA Rouault

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1996, Peer-reviewed

  
• REQUIREMENTS FOR IRON-REGULATED DEGRADATION OF THE RNA-BINDING PROTEIN, IRON REGULATORY PROTEIN-2

  K IWAI; RD KLAUSNER; TA ROUAULT

  EMBO JOURNAL, Nov. 1995, Peer-reviewed

  
• EXPRESSION OF A CONSTITUTIVE MUTANT OF IRON REGULATORY PROTEIN-1 ABOLISHES IRON HOMEOSTASIS IN MAMMALIAN-CELLS

  PA DERUSSO; CC PHILPOTT; K IWAI; HS MOSTOWSKI; RD KLAUSNER; TA ROUAULT

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1995, Peer-reviewed

  
• MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION

  M HATTORI; N TSUKAMOTO; MSA NUREKAMAL; B RUBINFELD; K IWAI; H KUBOTA; H MARUTA; N MINATO

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 1995, Peer-reviewed

  
• MOLECULAR CHARACTERIZATION OF A 2ND IRON-RESPONSIVE ELEMENT-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 - STRUCTURE, FUNCTION, AND POSTTRANSLATIONAL REGULATION

  F SAMANIEGO; J CHIN; K IWAI; TA ROUAULT; RD KLAUSNER

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1994, Peer-reviewed

  
• INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS

  H KUBOTA; M SATO; Y OGAWA; K IWAI; M HATTORI; T YOSHIDA; N MINATO

  INTERNATIONAL IMMUNOLOGY, Sep. 1994, Peer-reviewed

  
• Involvement of IL-7 in the development of γδ T cells in the thymus

  M. Tomana; S. Ideyama; K. Iwai; J. I. Gyotoku; W. T.V. Germeraad; S. Muramatsu; Y. Katsura

  Thymus, 1993, Peer-reviewed

  
• INVITRO INDUCTION OF IGG ANTI-DNA ANTIBODY FROM HIGH-DENSITY B-CELLS OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS BY AN HLA DR-RESTRICTED T-CELL CLONE

  M MURAKAMI; S KUMAGAI; M SUGITA; K IWAI; H IMURA

  CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Nov. 1992, Peer-reviewed

  
• A MURINE THYMIC STROMAL CELL-LINE WHICH MAY SUPPORT THE DIFFERENTIATION OF CD4-8- THYMOCYTES INTO CD4+8- ALPHA-BETA-T-CELL RECEPTOR POSITIVE T-CELLS

  Y WATANABE; O MAZDA; Y AIBA; K IWAI; J GYOTOKU; S IDEYAMA; J MIYAZAKI; Y KATSURA

  CELLULAR IMMUNOLOGY, Jul. 1992, Peer-reviewed

  
• QUALITATIVE DIFFERENCE OF ANTI-DNA ANTIBODY-PRODUCING CELL PRECURSORS IN THE PREIMMUNE B-CELL REPERTOIRE BETWEEN NORMAL AND LUPUS-PRONE MICE

  K IWAI; T TSUBATA; Y KATSURA; S KUMAGAI; H IMURA

  CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Oct. 1991, Peer-reviewed

  
• HLA-DQ-SPECIFIC AUTOREACTIVE T-CELL CLONE WITH HELPER AND CYTOTOXIC FUNCTIONS

  M SUGITA; S KUMAGAI; H UMEHARA; K IWAI; K SORACHI; H IMURA

  IMMUNOLOGY LETTERS, Dec. 1990, Peer-reviewed

  
• POSSIBLE DIFFERENT MECHANISMS OF B-CELL ACTIVATION IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS - OPPOSITE EXPRESSION OF LOW-AFFINITY RECEPTORS FOR IGE (CD23) ON THEIR PERIPHERAL B-CELLS

  S KUMAGAI; H ISHIDA; K IWAI; T TSUBATA; H UMEHARA; S OZAKI; T SUGINOSHITA; S ARAYA; H IMURA

  CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Dec. 1989, Peer-reviewed

  

Misc.

• Primary hemochromatosis as a disease provoked by hepcidin deficiency?

  Kazuhiro Iwai; Kyoko Hishikawa

  Nippon rinsho. Japanese journal of clinical medicine, 2006

  
• 直鎖型ユビキチンリガーゼLUBACの安定化機構の構造基盤研究

  徳永暉; 藤田宏明; WALINDA Erik; 大木出; 有吉眞理子; 杤尾豪人; 岩井一宏; 白川昌宏

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• 多彩な自己炎症性疾患を紐解く Linear ubiquitin assembly complexとOTULINによる炎症と細胞死の制御 OTULIN-related autoinflammatory syndrome患者の解析を通して

  植木 将弘; 松廣 淳平; 竹崎 俊一郎; 藤田 宏明; 三宅 紀子; 戸澤 雄介; 山田 雅文; 小林 一郎; 松本 直通; 有賀 正; 岩井 一宏; 真部 淳

  日本小児リウマチ学会総会・学術集会プログラム・抄録集, Oct. 2019

  
• ヘムを制御分子とする細胞内鉄濃度制御機構の構造化学的解明

  小倉麻梨子; 齋尾智英; 内田毅; 田中秀明; 田中秀明; 栗栖源嗣; 栗栖源嗣; 岩井一宏; 石森浩一郎

  日本蛋白質科学会年会プログラム・要旨集, 2017

  
• マウス骨肉腫肺転移モデルにおける新規ユビキチンリガーゼLUBACの機能解析

  友永 真人; 橋本 伸之; 徳永 文徳; 竹中 聡; 名井 陽; 岩井 一宏; 吉川 秀樹

  日本整形外科学会雑誌, Aug. 2011

  
• LM8マウス骨肉腫肺転移モデルにおける新規ユビキチンリガーゼlinear ubiquitin chain-assembly complex(LUBAC)の機能解析

  友永 真人; 橋本 伸之; 徳永 文徳; 名井 陽; 竹中 聡; 岩井 一宏; 吉川 秀樹

  日本整形外科学会雑誌, Jun. 2011

  
• マウス骨肉腫肺転移における新規NF-κB活性化経路(LUBAC)の役割

  友永 真人; 橋本 伸之; 徳永 文稔; 竹中 聡; 玉井 宣行; 名井 陽; 岩井 一宏; 吉川 秀樹

  日本整形外科学会雑誌, Aug. 2010

  
• Deficiency of the E3 Ligase Hoip Impairs Adult Hematopoiesis and Myeloid Leukemia

  Koji Jimbo; Shuhei Koide; Takahiro Ito; Arinobu Tojo; Katsuhiro Sasaki; Kazuhiro Iwai; Atsushi Iwama; Yasuhito Nannya; Takaaki Konuma

  BLOOD, Nov. 2021

  
• Ubiquitin system-mediated NF-κB signal regulation: identification of a novel linear polyubiquitination-dependent NF-κB regulation system

  徳永 文稔; 岩井 一宏

  Cell technology, 2010

  
• Inevitable roles of mitochondria in the regulation of cellular iron metabolism

  岩井 一宏; 武田 有紀子

  日本医師会雑誌, May 2010

  
• Linear polyubiquitin chain regulates immune response and inflammation

  藤田 宏明; 岩井 一宏

  医学のあゆみ, 10 Nov. 2012

  
• Linear ubiquitination mediates inflammatory and immune responses

  清水 覚司; 岩井 一宏

  医学のあゆみ, 20 Feb. 2016

  
• Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOIL1

  Donna Alexandra MacDuff; Tiffany A. Reese; Megan T. Baldridge; Jacqueline M. Kimmey; Leslie A. Weiss; Christina Song; Timothy J. Nice; Javier Carrero; Marco Colonna; Brian T. Edelson; David Sibley; Christina L. Stallings; Jean-Laurent Casanova; Kazuhiro Iwai; Skip Virgin

  FASEB JOURNAL, Apr. 2017

  
• Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与

  中澤 世識; 及川 大輔; 石井 亮平; 綾木 孝; 高橋 宏隆; 竹田 浩之; 石谷 隆一郎; 亀井 希代子; 竹吉 泉; 川上 秀史; 岩井 一宏; 畑田 出穂; 澤崎 達也; 伊東 秀文; 濡木 理; 徳永 文稔

  大阪市医学会雑誌, Dec. 2016

  
• ユビキチンシステムが切り開く新たな生命現象 LUBACアクセサリー分子SHARPINとHOIL-1Lがプログラム細胞死抑制において果たす機能的差異の解析

  清水 覚司; 藤田 宏明; 岩井 一宏

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異

  藤田 宏明; 清水 覚司; 徳永 暉; Walinda Erik; 高木 賢治; 水島 恒裕; 栃尾 豪人; 岩井 一宏

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Function of linear polyubiquitin chain in the activation of canonical NF-κB pathway

  佐々木 義輝; 岩井 一宏

  医学のあゆみ, 06 Oct. 2012

  
• 直鎖状ポリユビキチン鎖形成を担うE3リガーゼ複合体における非典型的なUBA-UBL相互作用

  矢木宏和; 石本和大; 廣本武史; 藤田宏明; 水島恒裕; 水島恒裕; 植草義徳; 矢木真穂; 栗本英治; 栗本英治; 野田勝紀; 内山進; 徳永文稔; 徳永文稔; 岩井一宏; 岩井一宏; 加藤晃一; 加藤晃一

  日本蛋白質科学会年会プログラム・要旨集, 2012

  
• Linear polyubiquitin chains: Discovery, function and future direction

  Kazuhiro Iwai

  Seikagaku, 2012

  
• A20の直鎖状ポリユビキチン鎖特異的結合を介したNF‐kappaB制御

  徳永文稔; 西増弘志; 石谷隆一郎; 後藤栄治; 野口拓也; 岩井一宏; 濡木理

  日本生化学会大会(Web), 2012

  
• LUBAC Regulates NF-kappa B Activation upon Genotoxic Stress by Promoting Linear Ubiquitination of NEMO

  Zhaohui Wu; Jixiao Niu; Yuling Shi; Kazuhiro Iwai

  FASEB JOURNAL, Apr. 2011

  
• 細胞質の鉄貯蔵たんぱく質フェリチンに貯蔵された鉄の運命

  浅野 剛史; 小松 雅明; 水島 昇; 岩井 一宏

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• Establishment of a new mice model of Parkinson's disease exhibiting decreased locomotive activity

  Shinichi Sakata; Nobutaka Hattori; Kazuhiro Iwai

  NEUROSCIENCE RESEARCH, 2010

  
• Mechanism underlying iron metabolism: Involvement of mitochondria in cellular iron sensing

  Kazuhiro Iwai; Ryo Ueta

  SEIKAGAKU, Nov. 2007

  
• Trivial change of iron metabolism can cause or deteriorate neurodegenerative symptoms

  Shin-ichi Sakata; Tomoko Nakagawa; Satoshi Ohashi; Taku Hatano; Kenji Yoshimi; Nobutaka Hattori; Kazuhiro Iwai

  NEUROSCIENCE RESEARCH, 2007

  
• ユビキチンと代謝応答 鉄代謝制御因子IRP2のユビキチン化機構の解析から明らかになったこと (ユビキチン-プロテアソーム系とオートファジー--作動機構と病態生理) -- (ユビキチン系の生理と病態)

  岩井 一宏; 石川 春人

  蛋白質核酸酵素, Aug. 2006

  
• 小胞体膜貫通型ユビキチンリガーゼ gp78 のE4 活性による変異型CFTR のユビキチン化

  森戸大介; 平尾和義; 細川暢子; 徳永文稔; 田中啓二; 岩井一宏; 永田和宏

  第1 回臨床ストレス応答学会大会，京都市，2006.11.22 －23, 2006, Peer-reviewed

  
• The functional analysis of novel ubiquitin-ligases: SCFFBG4 and SCFFBG5

  Koichi Miyashita; Fuminori Tokunaga; Yukiko Yoshida; Kazuhiro Iwai

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• A novel RING type ligase complex assembles a new type of polyubiquitin chain

  Takayoshi Kirisako; Shilzeo Murata; Keiji Tanaka; Fuminori Tokunaga; Kazuhiro Iwai

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• N型糖鎖を認識するユビキチンリガーゼ

  吉田 雪子; 川崎 博史; 岩井 一宏; 千葉 智樹; 鈴木 俊顕; 松岡 浩司; 田中 啓二; 田井 直

  生化学, Aug. 2001

  
• Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

  Kazuhiro Iwai; Koji Yamanaka; Takumi Kamura; Nagahiro Minato; Ronald C. Conaway; Joan W. Conaway; Richard D. Klausner; Arnim Pause

  Proceedings of the National Academy of Sciences of the United States of America, 26 Oct. 1999, Peer-reviewed

  
• Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

  Kazuhiro Iwai; Steven K. Drake; Nancy B. Wehr; Allan M. Weissman; Timothy LaVaute; Nagahiro Minato; Richard D. Klausner; Rodney L. Levine; Tracey A. Rouault

  Proceedings of the National Academy of Sciences of the United States of America, 28 Apr. 1998, Peer-reviewed

  

Presentations

• Linear ubiquitination an emerging regulator of inflammatory diseases and oncogenesis

  Kazuhiro Iwai

  NCI CCR Cancer Innovation Laboratory Seminar series, 22 Sep. 2023, Invited

  
• Regulation and function of LUBAC-mediated linear ubiquitination in immunity

  Kazuhiro Iwai

  The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “ from Neo-Biology to Targeted Protein Degradation”, 03 Dec. 2022, Invited

  
• Unexpected regulation and function of LUBAC-mediated linear ubiquitination in immunity

  Kazuhiro Iwai

  The first OIST-Kyoto;University Join;Workshop “Challenges in;Biomedical Complexities”, 02 Nov. 2022, Invited

  
• Unexpected functions of HOIL-1L E3: regulation of LUBAC, glycogen metabolism and beyond

  Kazuhiro Iwai

  EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”, 12 Sep. 2022, Invited

  
• Mechanisms underlying the formation and destabilization of the LUBAC ligase complex.

  Iwai, K; Fujita, H

  Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases”, Apr. 2018, Invited

  
• Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis

  IWAI Kazuhiro

  2017 International protein metabolism and disease conference, Jul. 2017, Invited

  
• Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death.

  Shimizu, S; Fujita, H; Sasaki, Y; Iwai, K

  EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases, Sep. 2015

  
• Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.

  IWAI Kazuhiro

  International Symposium on Ubiquitin and Diseases., Jun. 2015, Invited

  
• Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.

  IWAI Kazuhiro

  1st SPS International Symposium Xiamen University, Jun. 2015, Invited

  
• Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin

  Sakamoto, H; Egashira, S; Okabe, T; Nagano, T; Iwai, K

  Cold Spring Harbor Laboratory meeting “The Ubiquitin Family”, Apr. 2015

  
• Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.

  IWAI Kazuhiro

  1st International Symposium for New Aspects of the Ubiquitin Research, Nov. 2014, Invited

  
• Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons.

  Tamiya, H; Iwai, K

  The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein”, Oct. 2014

  
• Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling.

  IWAI Kazuhiro

  2014 International Conference on Protein Metabolism & Diseases, Jul. 2014, Invited

  
• Molecular mechanism and regulation of linear chain-mediated NF-B activation.

  Fujita, H; Takiuchi, T; Iwai, K

  Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”, Jun. 2014, Invited

  
• Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation.

  IWAI Kazuhiro

  THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development, Jun. 2014, Invited

  
• Increased redox-active iron induces mitochondrial damage that recruits Parkin.

  IWAI Kazuhiro

  The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment”, Mar. 2014, Invited

  
• Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells.

  Sasaki, Y; Fujita, H; Iwai, K

  The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”, Oct. 2013

  
• Linear polyubiquitination: a new regulator of NF-kappaB activation.

  IWAI Kazuhiro

  The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis”, Jul. 2013, Invited

  
• Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.

  IWAI Kazuhiro

  The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“, Nov. 2012, Invited

  
• Linear polyubiquitination: A crucial regulator of NF-kappaB signalling

  Fujita, H; Sasaki, Y; Nakahara; M. Iwai

  ZOMESVII conference, Sep. 2012, Invited

  
• Mechanism underlying generation of linear polyubiquitin chains.

  IWAI Kazuhiro

  4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012, Jul. 2012, Invited

  
• Linear polyubiquitination: a regulator of NF-kappaB activation.

  IWAI Kazuhiro

  FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation”, Jun. 2012, Invited

  
• Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.

  Iwai, K; Fujita, H; Nakahara, M; Sano, S; Tokunaga. F

  Keystone Symposium “NF-B signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling”, Mar. 2012, Invited

  
• Linear polyubiquitination : A new regulator of NF-kappaB activation.

  IWAI Kazuhiro

  The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology, Sep. 2011, Invited

  
• Linear polyubiquitination: a new regulator of NF-kappaB signaling.

  IWAI Kazuhiro

  Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN”, Nov. 2010, Invited

  
• Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae.

  Ueta, R; Iwai, K

  JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis, Jul. 2010, Invited

  
• Linear polyubiquitination: a new regulator of NF-kappaB signaling.

  IWAI Kazuhiro

  FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation”, Jun. 2010, Invited

  
• Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling.

  IWAI Kazuhiro

  “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation., Mar. 2010, Invited

  
• Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling.

  Iwai, K; Sakata, S.-I; Nakagawa, T; Tokunaga, F

  Keystone Symposium “NF-kappaB in Inflammation and Disease”, Jan. 2010

  
• Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling.

  Iwai, K; Tokunaga, F

  The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation”, Sep. 2009, Invited

  
• Involvement of linear polyubiquitination of NEMO in NF-kappaB activation.

  Tokunaga, F; Sakata, S.-I; Nakagawa, T; Iwai, K

  Cold Spring Harbor Laboratory meeting “The Ubiquitin Family”, Apr. 2009

  
• Physiological Function of Linear Polyubiquitin Chain.

  IWAI Kazuhiro

  Keystone Symposium “The Many Faces of Ubiquitin”, Jan. 2009, Invited

  
• Prevention of TNF-alpha induced apoptosis by linear polyubiquitination.

  IWAI Kazuhiro

  Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?”, Dec. 2008, Invited

  
• The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination.

  Miyauchi, Y; Kato, M; Tokunaga, F; Iwai, K

  ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis, Nov. 2008, Invited

  
• Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue.

  Iwai, K; Ueta, R; Shimohata, N; Sakata, S.-I; Kataoka, Y; Imaoka, S; Watanabe Y

  The International Conference on Fatigue Science, Sep. 2008, Invited

  
• Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism.

  IWAI Kazuhiro

  3nd International Workshop on Cell Regulations in Division and Arrest under Stress, Apr. 2008, Invited

  
• Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae.

  IWAI Kazuhiro

  Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function, Nov. 2007, Invited

  
• Linear ubiquitination of NEMO triggers NF-kappaB activation.

  Tokunaga, F; Sakata, S.-I; Kirisako, T; Nakagawa, T; Murata; S. Tanaka, K; Iwai, K

  The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation”, Sep. 2007

  
• Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role.

  Kirisako, T; Tokunaga, F; Nakamura, M; Iwai, K

  The Fourth NIBB-EMBL Symposium, Dec. 2006, Invited

  
• Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2

  IWAI Kazuhiro

  Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan, Nov. 2006, Invited

  
• Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2.

  Iwai; K. Kirisako, T; Tokunaga, F

  The 20th IUBMB, Jun. 2006, Invited

  
• Mechanism underlying oxidation-induced ubiquitylation.

  IWAI Kazuhiro

  The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases”, May 2004, Invited

  
• Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2.

  IWAI Kazuhiro

  3rd General Meeting of the International Proteolytic Society., Nov. 2003, Invited

  
• Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2

  Iwai, K; Yamanaka, K; Ishikawa, H; Rouault, T.A; Ishimori, K

  World Congress on Iron Metabolism, May 2003

  
• Identification of the ubiquitin-protein ligase that recognized oxidized IRP2.

  Yamanaka, K; Ishikawa, H; Megumi, Y; Tokunaga, F; Kanie M; Iwai, K

  Cold Spring Harbor Laboratory Symposium “Ubiquitin family”, Apr. 2003

  
• Identification of an ubiquitin-protein ligase recognizing oxidized proteins.

  IWAI Kazuhiro

  The 3rd International Symposium on Autophagy, Sep. 2002, Invited

  
• Isolation of the candidate of E3, which recognizes oxidized IRP2

  Iwai, K; Minato, N; Yamanaka, K

  FASEB summer research conference ”Ubiquitin and intracellular protein degradation”, Jun. 2001

  
• Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex

  IWAI Kazuhiro

  The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation", May 2000, Invited

  
• Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins.

  IWAI Kazuhiro

  The 6th CGGH symposium, May 1999, Invited

  
• Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway.

  Iwai, K; Drake, S.K; Wehr, N; Klausner, R.D; Weissman, A.M; Levine, R.L; Rouault, T.A

  FASEB summer reserch conference ”Ubiquitin and protein degradation”, Jun. 1997

  
• Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system.

  Iwai, K; Rouault, T.A; Klausner R.D

  FASEB summer research conference”Ubiquitin and protein degradation”, Jun. 1995

  

Industrial Property Rights

• 特表217972, UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF

  IWAI Kazuhiro

  
• 特許8,56,094 B2, UBIQUITIN LIGASE AND USE THEREOF

  IWAI Kazuhiro

  
• 特許5234865, 特願2009-184878, 新規なユビキチンリガーゼおよびその利用

  岩井 一宏

  
• 特願2007-151307, 破骨細胞制御剤とそのスクリーニング方法

  池田 恭治; 石井 晴朗; 岩井 一宏; 伊東 昌子

  

Awards

• 01 Nov. 2015

  The Japan Medical Association, Medical Award of The Japan Medical Association
• 09 Nov. 2017

  Mochida Memorial Foundation for Medical and Pharmaceutical Research, Academic Award of the Mochida Memorial Foundation
• 12 Nov. 2019

  Takeda Science Foundation, Takeda Medical Prize
• 11 Mar. 2020

  The Uehara Memorial Foundation, Uehara Prize
• 21 Jun. 2021

  Japan Academy, Japan Academy Prize

External funds: Kakenhi

• Functional regulation of ubiquitin chains using chemo-technologies

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  IWAI KAZUHIRO

  From 29 Jun. 2018, To 31 Mar. 2023, Project Closed

  ユビキチン;ケミカルツール;直鎖状ユビキチン鎖;ユビキチンシグナル;がん;自己免疫疾患;ステープルペプチド;炎症シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18H05499/
• New frontier for ubiquitin biology driven by chemo-technologies

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Tokyo Metropolitan Institute of Medical Science

  Yasushi SAEKI

  From 29 Jun. 2018, To 31 Mar. 2023, Project Closed

  ユビキチン;ケミカルバイオロジー;翻訳後修飾;タンパク質分解;標的タンパク質分解誘導剤;タンパク質化学合成;シグナル伝達;ステープルペプチド

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18H05497/
• Extensive analyses of the LUBAC ubiquitin ligase

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazuhiro Iwai

  From 31 May 2017, To 31 Mar. 2022, Project Closed

  ユビキチン;炎症制御;B細胞リンパ腫;LUBACリガーゼ;感染制御;グリコーゲン代謝異常;ミオパチー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H06174/
• ユビキチンネオバイオロジー：拡大するタンパク質制御システム

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  岩井 一宏

  From 01 Apr. 2017, To 31 Mar. 2018, Project Closed

  生体分子;ユビキチン;タンパク質;翻訳後修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-WRAPUP-17H06078/
• 直鎖状ユビキチン鎖による生体制御機構の解析

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  岩井 一宏

  From 01 Apr. 2017, To 31 Mar. 2018, Discontinued

  ユビキチン;炎症制御;Bリンパ腫;細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01534/
• Clarifying the pathogenesis of ABC-DLBCL in a mouse model

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Momoko Nishikori

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  悪性リンパ腫;マウスモデル;Ｂ細胞リンパ腫;MyD88;HOIP;NF-kappaB

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09474/
• Development of small molecules inhibiting linear ubiquitin-medaited NF-kappaB actviation

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  wai Kazuhiro

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  ユビキチン;NF-kappaB;LUBAC;直鎖状ユビキチン鎖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670154/
• Patho-physiological function of the ubiquitin ligase that generates linear ubiquitin chains (LUBAC)

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Kazuhiro IWAI

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  ユビキチン;慢性炎症;NF-kappaB;細胞死;生体分子医学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25253019/
• Multidisciplinary research on autophagy: from molecular mechanisms to disease states

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The University of Tokyo

  Noboru Mizushima

  From 28 Jun. 2013, To 31 Mar. 2018, Project Closed

  オートファジー;細胞内分解;リソソーム;蛋白質;細胞・組織;生理学;遺伝子;脳神経疾患;神経変性疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25111001/
• New aspect of the ubiquitin system : its enormous roles in protein regulation

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  From 28 Jun. 2012, To 31 Mar. 2017

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-3402/
• Development of regulators of the LUBAC ubiquitin ligase that modulate NF-kappaB activation

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Kazuhiro IWAI

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  細胞内シグナル伝達;シグナル伝達;直鎖状ポリユビキチン鎖;慢性皮膚炎;NF-kappaB;直鎖状ポリユビキチン鎖生成阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659136/
• Generation and function of linear ubiquitin chains

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Kazuhiro IWAI

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  直鎖状ユビキチン鎖;ユビキチン;NF-kappaB;Bリンパ球;B細胞リンパ腫;アスペルギルス;生体分子;直鎖状ポリユビキチン鎖;直鎖状ポリユビキチン鎖阻害剤;B細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24112002/
• New aspect of the ubiquitin system : its enormous roles in protein regulation

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Kazuhiro IWAI

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  領域内研究者交流;情報交換;若手支援;国際化推進;研究技法共有;生体分子;ユビキチン;タンパク質;翻訳後修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-24112001/
• Novel activation pathway of NF-kB via LUBAC in patient with rheumatoid arthritis

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Tetsuya TOMITA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  arthritis;inflammation;NF kappa B;LUBAC;関節リウマチ;NF-kB

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591685/
• Analysis of pathophysiology of LUBAC mediated NF-kappaB activation

  Grant-in-Aid for Scientific Research (A)

  Kyoto University;Osaka University

  Kazuhiro IWAI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  細胞内シグナル伝達;直鎖状ポリユビキチン鎖;LUBAC;NF-kappaB;ユビキチン;アレルギー;免疫異常;NF-κB;皮膚炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22249008/
• Relationship between inflammation and novel NF-κB activation pathway which is regulated by ubiquitin system

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Fuminori TOKUNAGA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  分子腫瘍学;蛋白質;酵素;細胞・組織;炎症;ユビキチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390097/
• PUBドメイン含有ユビキチンリガーゼの品質管理における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  徳永 文稔

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  タンバク質;酵素の調節;細胞内タンパク質分解;タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20059031/
• Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for

  Grant-in-Aid for Scientific Research (B)

  Juntendo University

  Nobutaka HATTORI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  パーキンソン病;遺伝性パーキンソン病;共通機構;新規原因遺伝子;劣性遺伝性パーキンソン病;ミトコンドリア機能;PINK1;Parkin;DJ-1;autophagy-lysosomal path&;ATP132;ユビキチン化;常染色体劣性晩発性パーキンソン病;連鎖解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390244/
• Proteolysis in the Regulation of Biological Processes

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  Noboru MIZUSHIMA

  From 01 Apr. 2006, To 31 Mar. 2012, Project Closed

  タンパク質分解;ユビキチン;オートファジー;カルパイン;プロテアーゼ;プロテオリシス;細胞内情報伝達;細胞構造・機能;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18076008/
• Mechanism underlying selective substrate recognition by the ubiquitin system

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University;Osaka City University

  Kazuhiro IWAI

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  タンパク質;分解;ユビキチン;蛋白質;ストレス;癌;生体分子;タンパク質分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18076004/
• 鉄イオンによる転写制御機構の分子基盤

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  岩井 裕子

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  転写制御;鉄代謝;鉄-硫黄クラスター;核外移行;出芽酵母

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18055016/
• Involvement of ubiquitin system on the hepatitis B virus X protein (HBx)-mediated transactivation activity

  Grant-in-Aid for Scientific Research (C)

  Osaka City University

  Fuminori TOKUNAGA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ウイルス;癌;酵素;細胞・組織;蛋白質, protein;enzyme;virus;transcription

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590274/
• 鉄イオンによる転写制御の分子基盤

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  岩井 裕子

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  転写制御;鉄代謝;出芽酵母;鉄-硫黄クラスター;核外移行

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17054019/
• 新規RING型ユビキチンリガーゼ複合体のタンパク質品質管理における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka City University

  徳永 文稔

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  酵素;細胞・組織;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17028048/
• Roles of mitochondria in iron metabolism

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yuko IWAI

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  ミトコンドリア;鉄代謝;鉄-硫黄クラスター;ノックアウト;出芽酵母;鉄-硫黄ラスター;DT40;鉄;鉄ー硫黄クラスター;トリBリンパ細胞, mitochondria;iron metabolism;iron-sulfur cluster;knock-out;Saccharomyces cerevisiae

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16370061/
• Effects of HOIL-1 ubiquitin ligase complex on the physiological function of hepatitis B virus X protein

  Grant-in-Aid for Scientific Research (C)

  Osaka City University

  Fuminori TOKUNAGA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  ユビキチン;B型肝炎ウイルス;肝細胞癌;トランス活性化;B型肝炎ウィルス, ubiquitin;hepatitis B virus;NF-κB;transactivation;henatocarcinoma

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590279/
• 酸化修飾認識ユビキチンリガーゼ(HOIL-1)のタンパク質品質管理における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka City University

  徳永 文稔

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  酵素;細胞・組織;ストレス;蛋白質;ユビキチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15032250/
• Physiology and pathology of the ubiquitin-mediated quality control system

  Grant-in-Aid for Creative Scientific Research

  Osaka City University

  Kazuhiro IWAI

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  蛋白質;生体分子;ストレス;癌;脳神経疾患, protein;biological molecules;stress;cancer;neurodegenerative diseases

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14GS0322/
• 酸化タンパクを識別するユビキチンリガーゼHOIL―1の機能解析

  Grant-in-Aid for Scientific Research (B)

  Osaka City University

  岩井 一宏

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  蛋白質;生体分子;ストレス;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14380307/
• ユビキチンワールド:新しい生体反応制御システム

  Grant-in-Aid for Scientific Research (C)

  Hokkaido University

  横沢 英良

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ユビキチン;細胞周期;ストレス応答;ユビキチン様蛋白質;脱ユビキチン化;プロテアソーム;ユビキチンワールド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12898019/
• がん抑制遺伝子産物pVHLユビキチンリガーゼ欠損による発がん機構

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  岩井 一宏

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  VHL;腎細胞癌;ユビキチン修飾;HIF-1;プロテアソーム;選択的蛋白分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12213065/
• 酸化変化を認識するユビキチンシステムの神経変性疾患の封入体形成への関与

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  岩井 一宏

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  酸化ストレス;ユビキチン修飾;鉄イオン代謝異常;神経変性疾患;IRP2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12210082/
• pVHLリガーゼによる環境応答

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka City University;Kyoto University

  岩井 一宏

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  ストレス;環境;ユビキチン修飾;VHL;選択的蛋白分解;pVHLリガーゼ;腎細胞癌;PKCλ;IRP2;ユビキチン;酸化修飾;HIF-1;プロテアソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12146202/
• Identification of a ubiquitin-ligase which recognizes oxidized proteins.

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazuhiro IWAI

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  酸化変化;ユビキチン修飾;鉄イオン代謝;IRP2;プロテアソーム;選択的蛋白分解, Oxidative modificatin;ubiquitination;iron metabolism;IRP2;proteasome;selective proteolysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680630/
• 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  岩井 一宏

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  酸化変化;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11144220/
• 細胞内鉄濃度を制御する転写因子の鉄センシング機構と転写活性化機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  岩井 裕子

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  出芽酵母;細胞内鉄濃度;転写因子;代謝;鉄取り込み;バンド・シフト法;鉄センシング機構;核移行

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11116217/
• 低分子G蛋白シグナル系を介した造血系細胞分化制御機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kyoto University

  服部 雅一

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  SPA-1;Rap1;cell adhesion;C3G;32D;integrin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10181211/
• 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  岩井 一宏

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  酸化変化;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10163220/
• Molecular mechanisms of lymphocyte proliferation during the development

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nagahiro MINATO

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  低分子G蛋白;Rap1;Ras;細胞骨格;シグナル伝達;抗原レセプター;免疫応答;GTPase活性化蛋白(GAP);アナ-ジ-;バキュロウイルス;低分子量G蛋白;クローン増巾;GTPase活性化蛋白, Small GTPases;Rap 1;Ras;Cytaskleton;Signal transduction;Antigen receptors;Immune response;GTPase activating protain(GAP)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470093/
• 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  岩井 一宏

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  酸化的修飾;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09267218/
• Molecular mechanisms for cell cycle control in the immune system

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Nagahiro MINATO

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  リンパ球;低分子量G蛋白;Rap1;GTPase活性化蛋白;細胞周期;バキュロウイルス;細胞増殖;染色体マッピング;低分子G蛋白;G蛋白活性化蛋白;がん遺伝子;がん抑制遺伝子;シグナル伝達;サイトカイン;リンパ球活性化;細胞分裂;細胞同期;核内蛋白;ロイシンジッパー, lymphocutes;small G protein;Rap1;GTPase activating protein;cell cycle;baculovirus;proliferation;chusmosomal mapping

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457084/
• Integrated analyses of LUBAC-mediated linear ubiquitination

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Kyoto University

  岩井 一宏

  From 27 Apr. 2022, To 31 Mar. 2027, Granted

  炎症シグナル;直鎖状ユビキチン鎖;自己免疫疾患;癌慢性炎症;細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04988/
• Involvement of linear ubiquitination in regulation of cancer and immunity

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 48:Biomedical structure and function and related fields

  Kyoto University

  岩井 一宏

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  炎症シグナル;直鎖状ユビキチン鎖;自己免疫疾患;癌慢性炎症;細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00444/

External funds: others

• 地域医療支援センター運営事業（京都大学ブランチ事業） (2022年度分)

  京都府, 地域医療介護総合確保基金

  From 01 Apr. 2022, To 31 Mar. 2023

  代表

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology I

  E006, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Physiology

  B008, Fall, Faculty of Medicine, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology II

  E007, Fall, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology

  B007, Fall, Faculty of Medicine, 3.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Physiology

  L052, Fall, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Physiology

  B008, Fall, Faculty of Medicine, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology

  L051, Fall, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology

  B007, Fall, Faculty of Medicine, 3.5
• From Apr. 2013, To Mar. 2014

  Physiology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Physiology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Physiology I

  Fall, 医学研究科
• From Apr. 2014, To Mar. 2015

  Physiology II

  Fall, 医学研究科
• From Apr. 2014, To Mar. 2015

  Physiology

  Fall, 医学研究科
• From Apr. 2015, To Mar. 2016

  Physiology

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Physiology II

  Fall, 医学研究科
• From Apr. 2015, To Mar. 2016

  Physiology I

  Fall, 医学研究科
• From Apr. 2015, To Mar. 2016

  Physiology

  Fall, 医学研究科
• From Apr. 2015, To Mar. 2016

  Physiology

  Fall, 工学研究科
• From Apr. 2016, To Mar. 2017

  Physiology

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Physiology II

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Physiology I

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Physiology

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Physiology

  Fall, 工学研究科
• From Apr. 2018, To Mar. 2019

  Physiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Physiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Physiology II

  Spring, 医学部（人間健康科学科）
• From Apr. 2018, To Mar. 2019

  Physiology II

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Physiology I

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Physiology

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  Physiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Physiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Physiology II

  Spring, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Physiology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Physiology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Physiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Physiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Physiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Physiology II

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Physiology I

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Physiology

  Fall, 医学研究科

Administration

School management (title, position)

• From 01 Apr. 2024

  大学評価委員会 委員
• From 01 Apr. 2024

  技術支援企画委員会 委員長
• From 01 Oct. 2022, To 30 Sep. 2024

  企画委員会 委員長
• From 01 Oct. 2022, To 30 Sep. 2024

  役員会
• From 01 Oct. 2022, To 30 Sep. 2024

  理事
• From 11 Oct. 2022

  国際卓越研究大学構想検討委員会 委員長
• From 01 Oct. 2022, To 30 Sep. 2024

  戦略調整会議 議長
• From 01 Oct. 2021, To 30 Sep. 2022

  産官学連携本部運営協議会 委員
• From 01 Oct. 2021, To 30 Sep. 2022

  研究公正推進委員会 委員
• From 01 Feb. 2022, To 30 Jun. 2022

  戦略調整会議研究戦略・人材育成検討委員会 委員
• From 01 Apr. 2022, To 30 Sep. 2022

  学生総合支援機構運営委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  京都大学スーパーグローバルコース実施運営協議会 委員
• From 01 Apr. 2013, To 31 Mar. 2015

  学生生活委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2015

  奨学金返還免除候補者選考委員会 委員
• From 01 Oct. 2016, To 30 Sep. 2018

  企画委員会 委員
• From 01 May 2015, To 30 Apr. 2017

  国際高等教育院 企画評価専門委員会 生物学部会 委員
• From 01 Oct. 2017, To 31 Mar. 2019

  教育研究評議会 評議員
• From 01 Oct. 2018, To 30 Sep. 2020

  医学研究科 研究科長
• From 01 Oct. 2018, To 30 Sep. 2020

  医学部 学部長
• From 01 Oct. 2018, To 30 Sep. 2020

  医学教育・国際化推進センター長
• From 01 Oct. 2018, To 30 Sep. 2020

  企画委員会 委員
• From 24 Jul. 2018, To 30 Sep. 2020

  企画委員会 若手重点戦略定員専門委員会 委員
• From 01 Oct. 2018, To 31 Mar. 2021

  京都大学情報環境整備委員会 委員
• From 01 Oct. 2018

  全学情報セキュリティ委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  国際高等教育院 教養・共通教育協議会 協議員
• From 01 Oct. 2018, To 30 Sep. 2020

  国際高等教育院 大学院共通・横断教育基盤協議会 協議員
• From 01 Oct. 2018, To 31 Mar. 2020

  京都大学スーパーグローバルコース実施運営協議会 委員
• From 01 Oct. 2018, To 31 Mar. 2020

  大学院横断教育プログラム推進センター運営協議会 協議員
• From 01 Oct. 2018, To 30 Sep. 2020

  入学試験委員会 委員
• From 01 Apr. 2019, To 30 Sep. 2020

  競争的資金等の不正防止計画推進室 室員
• From 01 Apr. 2019, To 30 Sep. 2020

  研究公正推進委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  研究公正委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  京都大学利益相反マネジメント委員会 委員
• From 01 Oct. 2018, To 09 Sep. 2019

  産学共同実用化促進事業実施委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  産官学連携本部運営協議会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  環境安全保健委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  教育研究評議会 評議員
• From 01 Oct. 2018, To 30 Sep. 2020

  部局長会議
• From 01 Oct. 2018, To 30 Sep. 2020

  研究科長部会
• From 01 Oct. 2018, To 30 Sep. 2020

  基金運営委員会 委員
• From 01 Oct. 2018, To 31 Mar. 2019

  教員活動評価委員会 委員
• 核燃料物質専門委員会
• 原子力研究整備委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  情報環境整備委員会
• From 01 Oct. 2018, To 30 Sep. 2020

  創立百二十五周年記念事業委員会幹事会
• From 01 Oct. 2018, To 31 Mar. 2020

  京都大学学術研究支援室運営委員会 委員
• From 01 Oct. 2018, To 31 Mar. 2020

  京都大学研究者情報整備委員会
• From 01 Oct. 2018, To 30 Jun. 2020

  環境安全保健機構運営協議会協議員
• From 06 Feb. 2019

  全学教員部教員選考会議(環境安全保健機構)構成員
• From 01 Oct. 2018, To 30 Sep. 2020

  スーパーグローバルコース実施運営協議会 協議員
• From 01 Oct. 2018, To 30 Sep. 2020

  大学院横断教育プログラム推進センター運営協議会 協議員
• From 01 Apr. 2020, To 30 Sep. 2020

  京都大学研究者情報整備委員会 委員
• From 01 Oct. 2018, To 31 Mar. 2022

  京都大学利益相反マネジメント委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  京都大学研究者情報整備委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2021

  国際高等教育院 教養・共通教育協議会 協議員
• From 01 Oct. 2020, To 30 Sep. 2021

  国際高等教育院 大学院共通・横断教育協議会 協議員
• From 01 Oct. 2020, To 30 Sep. 2022

  企画委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2021

  全学情報セキュリティ委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2021

  医学研究科 研究科長
• From 01 Oct. 2020, To 30 Sep. 2021

  医学部 学部長
• From 01 Oct. 2020, To 30 Sep. 2022

  医学教育・国際化推進センター センター長
• From 01 Oct. 2020, To 30 Sep. 2021

  スーパーグローバルコース企画運営幹事会 協議員
• From 01 Oct. 2020, To 30 Sep. 2021

  入学試験委員会 委員
• From 01 Oct. 2018

  原子力研究整備委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2021

  研究公正推進委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2022

  競争的資金等の不正防止計画推進室 室員
• From 01 Oct. 2020, To 30 Sep. 2021

  産官学連携本部運営協議会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  基金運営委員会 委員
• From 01 Apr. 2021, To 30 Sep. 2021

  環境安全保健委員会 委員
• From 01 Apr. 2021, To 30 Sep. 2022

  京都大学経営協議会
• From 01 Oct. 2020, To 30 Sep. 2021

  教育研究評議会 評議員
• From 01 Oct. 2020, To 30 Sep. 2021

  部局長会議
• From 01 Oct. 2020, To 30 Sep. 2021

  研究科長部会
• From 01 Apr. 2021, To 30 Sep. 2021

  人事審査委員会 委員

Faculty management (title, position)

• From 01 Oct. 2022, To 30 Sep. 2024

  関係病院人事連絡委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科・医学部将来計画検討委員会委員
• From 01 Oct. 2012, To 30 Sep. 2020

  人事連絡委員会
• From 01 Oct. 2017, To 31 Mar. 2019

  副研究科長
• From 01 Sep. 2013, To 31 Mar. 2015

  医学図書館図書連絡委員
• From 01 Oct. 2017, To 30 Sep. 2020

  医学研究科・医学部将来計画検討委員会
• From 01 Apr. 2013, To 30 Sep. 2020

  医学研究科等防犯カメラ設置運用委員会
• To 31 Mar. 2018

  医学研究科運営委員会
• From 01 Oct. 2016, To 30 Sep. 2018

  管理体制委員会
• From 01 Apr. 2013, To 10 Jun. 2015

  基礎系副専攻長
• From 01 Apr. 2017

  M.D./Ph.D.コース運営委員会
• From 01 Apr. 2015, To 30 Sep. 2018

  大倉辰三郎・喜美奨学金 選考小委員会
• From 01 Oct. 2018, To 30 Sep. 2020

  動物実験施設管理委員会
• From 01 Apr. 2018, To 30 Sep. 2020

  学務委員会
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（創薬医学）
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（免疫ゲノム医学）
• From 24 Sep. 2015

  教員人事活性化委員会
• From 01 Apr. 2016, To 31 Mar. 2018

  再生医科学研究所運営委員会
• From 01 Oct. 2017, To 31 Mar. 2019

  病院長・評議員
• 医学研究科・医学部財務委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  ウイルス・再生医科学研究所・再生医学・再生医療の先端融合的共同研究拠点運営委員会
• From 01 Apr. 2018, To 31 Mar. 2019

  医学図書館図書連絡委員
• From 01 Oct. 2018, To 30 Sep. 2021

  医学研究科長・医学部長
• From 01 Oct. 2018, To 30 Sep. 2020

  附属医学教育・国際化推進センター
• 医学教育・国際化推進センター運営委員会
• From 01 Oct. 2017, To 30 Sep. 2020

  医学図書館図書運営委員
• 放射線障害防止委員会
• From 01 Oct. 2018, To 30 Sep. 2021

  学術情報システム・情報セキュリティ委員会
• IFOM－KU 国際共同ラボ 運営委員会
• From 01 Oct. 2018, To 30 Sep. 2020

  京都大学医薬系総合研究棟管理運営委員会
• To 30 Sep. 2021

  京都大学分子生物実験研究棟管理運営委員会
• From 01 Oct. 2018, To 30 Sep. 2020

  京都大学白眉センター運営委員会
• From 01 Dec. 2018, To 30 Jun. 2020

  京都大学白眉センター伯楽会議委員
• From 01 Oct. 2018, To 30 Sep. 2020

  大学院総合生存学館教授会(思修館協議会)
• From 01 Feb. 2018, To 31 Mar. 2020

  ウイルス・再生医科学研究所諮問会議委員
• From 01 Apr. 2021, To 30 Sep. 2021

  白眉センター伯楽会議委員
• From 01 Oct. 2020, To 30 Sep. 2022

  情報環境機構　協議会　委員
• From 01 Oct. 2020, To 30 Sep. 2021

  柳井基金運営委員会委員

Academic, Social Contribution

Committee Memberships

• From Nov. 2019, To Present

  理事, 日本生化学会
• From 2013, To Present

  理事, 日本鉄バイオサイエンス学会