Basic Information

Faculty

• 農学部

Professional Memberships

• 日本農薬学会
• 日本生化学会
• 日本農芸化学会
• Pesticide Science Society of Japan
• The Japanese Biochemical Society
• Japan Society for Bioscience, Biotechnology, and Agrochemistry

Academic Degree

• 農学修士(京都大学)
• 農学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院農学研究科修士課程農芸化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 岡山大学, 農学部農芸化学科, 卒業

Profile

• Profile

  昭和５７年３月　岡山大学農学部 農芸化学科卒業、昭和５９年３月　京都大学大学院農学研究科 農芸化学専攻修士課程修了、昭和６１年３月　京都大学大学院農学研究科 農芸化学専攻後期博士課程中退、昭和６１年４月　京都大学 助手（農学部）、平成　６年４月　京都大学 助教授（農学部）、平成２０年５月　京都大学 教授（農学部）。

Language of Instruction

• English

ID,URL

• J-Global ID

  200901056262877020

researchmap URL

• https://researchmap.jp/read0013050

Research

Research Topics, Overview of the research

• Research Topics

  Chemical biological studies on mitochondrial respiratory enzymes and transporters

• Overview of the research

  プロトン輸送性 NADH-ユビキノン酸化還元酵素（複合体－Ｉ）は、ミトコンドリア呼吸鎖の初発酵素であり、NADH から放出される２電子によってユビキノンを還元し、これと共役して４個のプロトンをポンプする。哺乳類ミトコンドリアの複合体－Ｉは、45個の異なるサブユニットから構成される巨大な酵素複合体であるために、呼吸鎖酵素中で最も研究の進展が遅れている酵素である。阻害剤の有機合成と作用機構研究を基盤として、複合体-Ｉ研究を進展させることを目指している。
  
  また、種々のエネルギー変換生体膜におけるユビキノンやカルジオリピンの生理機能の解明を目指した生物有機化学研究も展開している。

Research Interests

• カルジオリピン
• ユビキノン
• ミトコンドリア
• 呼吸鎖酵素
• 生物有機化学
• Caldiolipin
• Structure-Activity relation
• Ubiquinone
• Respiratory Inhibitor
• Respiratory Enzyme
• bioenergetics
• inhibitor of respiratory enzymes
• complex I

Research Areas

• Life sciences, Bioorganic chemistry

Papers

• Pinpoint introduction of functional molecular probe into the NqrB subunit of Na+-translocating NADH-ubiquinone oxidoreductase from Vibrio cholerae

  Saya Miyachi; Hinako Tanaka; Moe Ishikawa; Danielle Mcfee; Wataru Aoki; Masatoshi Murai; Blanca Barquera; Hideto Miyoshi; Takahiro Masuya

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Mar. 2025

  
• Mitochondrial respiratory complex I can be inhibited via bypassing the ubiquinone-accessing tunnel

  Ryohei Otani; Takahiro Masuya; Hideto Miyoshi; Masatoshi Murai

  FEBS Letters, Jun. 2024, Peer-reviewed

  
• Identification of proteins involved in intracellular ubiquinone trafficking in Saccharomyces cerevisiae using artificial ubiquinone probe

  Mirai Mizutani; Seina Kuroda; Masahide Oku; Wataru Aoki; Takahiro Masuya; Hideto Miyoshi; Masatoshi Murai

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Jun. 2024

  
• Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones

  Ryo Ikunishi; Ryohei Otani; Takahiro Masuya; Kyoko Shinzawa-Itoh; Tomoo Shiba; Masatoshi Murai; Hideto Miyoshi

  Journal of Biological Chemistry, Jun. 2023

  Access this paper :

  
• Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I)

  Atsuhito Tsuji; Takahiro Masuya; Norihito Arichi; Shinsuke Inuki; Masatoshi Murai; Hideto Miyoshi; Hiroaki Ohno

  ACS Medicinal Chemistry Letters, 24 Jan. 2023

  Access this paper :

  
• Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae

  Jun-ichi Kishikawa; Moe Ishikawa; Takahiro Masuya; Masatoshi Murai; Yuki Kitazumi; Nicole L. Butler; Takayuki Kato; Blanca Barquera; Hideto Miyoshi

  Nature Communications, Dec. 2022

  Access this paper :

  
• 2P305 Probing proton channel in cytochrome bd-type ubiquinol oxidase by site-directed mutagenesis(41. Proton and ion pumping,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

  Mogi Tatsushi; Miyoshi Hideto

  Seibutsu Butsuri, 2006

  
• 新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定

  山下 哲生; 稲岡 健ダニエル; 志波 智生; 大橋 拓未; 岩田 想; 矢木 隆雄; 小坂 博昭; 三芳 秀人; 原田 繁春; 北 潔; 平野 勝也

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I

  Shinpei Uno; Takahiro Masuya; Oleksii Zdorevskyi; Ryou Ikunishi; Kyoko Shinzawa-Itoh; Jonathan Lasham; Vivek Sharma; Masatoshi Murai; Hideto Miyoshi

  Journal of Biological Chemistry, May 2022

  Access this paper :

  
• Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

  Daniel N. Grba; James N. Blaza; Hannah R. Bridges; Ahmed-Noor A. Agip; Zhan Yin; Masatoshi Murai; Hideto Miyoshi; Judy Hirst

  Journal of Biological Chemistry, Mar. 2022

  
• The side chain of ubiquinone plays a critical role in Na+ translocation by the NADH-ubiquinone oxidoreductase (Na+-NQR) from Vibrio cholerae

  Moe Ishikawa; Takahiro Masuya; Seina Kuroda; Shinpei Uno; Nicole L. Butler; Sara Foreman; Masatoshi Murai; Blanca Barquera; Hideto Miyoshi

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Mar. 2022

  
• Comprehensive understanding of multiple actions of anticancer drug tamoxifen in isolated mitochondria

  Yufu Unten; Masatoshi Murai; Tomoki Koshitaka; Kotaro Kitao; Osamu Shirai; Takahiro Masuya; Hideto Miyoshi

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Dec. 2021

  
• Natural tetramic acids elicit multiple inhibitory actions against mitochondrial machineries presiding over oxidative phosphorylation

  Yufu Unten; Masatoshi Murai; Katsuyuki Sakai; Yukihiro Asami; Takenori Yamamoto; Takahiro Masuya; Hideto Miyoshi

  Bioscience, Biotechnology, and Biochemistry, 08 Oct. 2021

  Access this paper :

  
• Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria.

  Katsuyuki Sakai; Yufu Unten; Aoi Kimishima; Kenichi Nonaka; Takumi Chinen; Kazunari Sakai; Takeo Usui; Kazuro Shiomi; Masato Iwatsuki; Masatoshi Murai; Hideto Miyoshi; Yukihiro Asami; Satoshi Ōmura

  Journal of industrial microbiology & biotechnology, 03 Aug. 2021

  
• Specific chemical modification explores dynamic structure of the NqrB subunit in Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae

  Moe Ishikawa; Takahiro Masuya; Hinako Tanaka; Wataru Aoki; Noam Hantman; Nicole L. Butler; Masatoshi Murai; Blanca Barquera; Hideto Miyoshi

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Aug. 2021

  
• Pinpoint Dual Chemical Cross-Linking Explores the Structural Dynamics of the Ubiquinone Reaction Site in Mitochondrial Complex I

  Takahiro Masuya; Shinpei Uno; Masatoshi Murai; Hideto Miyoshi

  Biochemistry, 16 Mar. 2021

  
• Inhibitors of a Na+-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function

  Takahiro Masuya; Yuki Sano; Hinako Tanaka; Nicole L Butler; Takeshi Ito; Tatsuhiko Tosaki; Joel E. Morgan; Masatoshi Murai; Blanca Barquera; Hideto Miyoshi

  Journal of Biological Chemistry, 20 Jul. 2020, Peer-reviewed

  
• Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.

  Kento Tsukada; Shono Shinki; Akiho Kaneko; Kazuma Murakami; Kazuhiro Irie; Masatoshi Murai; Hideto Miyoshi; Shingo Dan; Kumi Kawaji; Hironori Hayashi; Eiichi N Kodama; Aki Hori; Emil Salim; Takayuki Kuraishi; Naoya Hirata; Yasunari Kanda; Teigo Asai

  Nature communications, 14 Apr. 2020, Peer-reviewed

  Access this paper :

  
• IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism

  Tsuji A; Akao T; Masuya T; Murai M; Miyoshi H

  The Journal of Biological Chemistry, Apr. 2020, Peer-reviewed

  Access this paper :

  
• Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I

  Uno S; Masuya T; Shinzawa-Itoh K; Lasham J; Haapanen O; Shiba T; Inaoka K D; Sharma V; Murai M; Miyoshi H

  J. Biol. Chem., 2020, Peer-reviewed

  
• Photoaffinity labeling of respiratory complex I in bovine heart submitochondrial particles by photoreactive [125I]amilorides

  Murai M; Miyoshi H

  Bio-protocol, Sep. 2019, Peer-reviewed, Invited

  
• Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae.

  Katsuyuki Sakai; Yufu Unten; Masato Iwatsuki; Hirotaka Matsuo; Wataru Fukasawa; Tomoyasu Hirose; Takumi Chinen; Kenichi Nonaka; Takuji Nakashima; Toshiaki Sunazuka; Takeo Usui; Masatoshi Murai; Hideto Miyoshi; Yukihiro Asami; Satoshi Ōmura; Kazuro Shiomi

  The Journal of antibiotics, Sep. 2019, Peer-reviewed

  
• Antibiotic Korormicin A Kills Bacteria by Producing Reactive Oxygen Species.

  Maynard A; Butler NL; Ito T; da Silva AJ; Murai M; Chen T; Koffas MAG; Miyoshi H; Barquera B

  Journal of bacteriology, Jun. 2019, Peer-reviewed

  
• Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I.

  Banba A; Tsuji A; Kimura H; Murai M; Miyoshi H

  The Journal of biological chemistry, Apr. 2019, Peer-reviewed

  
• Pentenediol-Type Compounds Specifically Bind to Voltage-Dependent Anion Channel 1 in Saccharomyces cerevisiae Mitochondria.

  Unten Y; Murai M; Yamamoto T; Watanabe A; Ichimaru N; Aburaya S; Aoki W; Shinohara Y; Miyoshi H

  Biochemistry, Feb. 2019, Peer-reviewed

  
• Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches.

  Uno S; Kimura H; Murai M; Miyoshi H

  The Journal of biological chemistry, Jan. 2019, Peer-reviewed

  
• Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

  Tetsuo Yamashita; Daniel Ken Inaoka; Tomoo Shiba; Takumi Oohashi; So Iwata; Takao Yagi; Hiroaki Kosaka; Hideto Miyoshi; Shigeharu Harada; Kiyoshi Kita; Katsuya Hirano

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

  Access this paper :

  
• Epoxycyclohexenedione-Type Compounds Make Up a New Class of Inhibitors of the Bovine Mitochondrial ADP/ATP Carrier

  Ayaki Aoyama; Masatoshi Murai; Naoya Ichimaru; Shunsuke Aburaya; Wataru Aoki; Hideto Miyoshi

  Biochemistry, 13 Feb. 2018, Peer-reviewed

  
• Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

  Yoshihiro Watanabe; Yukihiro Asami; Satomi Narusawa; Shohei Hashimoto; Masato Iwatsuki; Kenichi Nonaka; Yasuo Shinohara; Takahiro Shiotsuki; Naoya Ichimaru; Hideto Miyoshi; Satoshi Omura; Kazuro Shiomi

  Journal of Antibiotics, 01 Jan. 2018, Peer-reviewed

  
• Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes

  Masato Abe; Yoshiki Sawada; Shinpei Uno; Shuhei Chigasaki; Masahide Oku; Yasuyoshi Sakai; Hideto Miyoshi

  BIOCHEMISTRY, Nov. 2017, Peer-reviewed

  
• Pinpoint Chemical Modification of the Quinone-Access Channel of Mitochondrial Complex I via a Two-Step Conjugation Reaction

  Takahiro Masuya; Masatoshi Murai; Takeshi Ito; Shunsuke Aburaya; Wataru Aoki; Hideto Miyoshi

  BIOCHEMISTRY, Aug. 2017, Peer-reviewed

  
• Tissue-specific expression and silencing phenotypes of mitochondrial phosphate carrier paralogues in several insect species

  R. Sugahara; A. Jouraku; T. Nakakura; M. Minaba; T. Yamamoto; Y. Shinohara; H. Miyoshi; T. Shiotsuki

  INSECT MOLECULAR BIOLOGY, Jun. 2017, Peer-reviewed

  
• Identification of the binding sites for ubiquinone and inhibitors in the Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling

  Takeshi Ito; Masatoshi Murai; Satoshi Ninokura; Yuki Kitazumi; Katherine G. Mezic; Brady F. Cress; Mattheos A. G. Koffas; Joel E. Morgan; Blanca Barquera; Hideto Miyoshi

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2017, Peer-reviewed

  
• Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

  Yoshihiro Watanabe; Takuya Suga; Satomi Narusawa; Masato Iwatsuki; Kenichi Nonaka; Takuji Nakashima; Yasuo Shinohara; Takahiro Shiotsuki; Naoya Ichimaru; Hideto Miyoshi; Yukihiro Asami; Satoshi Omura; Kazuro Shiomi

  JOURNAL OF ANTIBIOTICS, Apr. 2017, Peer-reviewed

  
• Characterization of the ubiquinone-binding protein Coq10 using a synthetic ubiquinone probe (in Japanese)

  Murai M; Miyoshi H

  Japanese Journal of Pesticide Science, Feb. 2017, Peer-reviewed, Invited

  
• Action mechanism of the inhibitors of mitochondrial respiratory complex I based on structure-activity relationship (SAR) studies (in Japanese)

  Miyoshi H; Murai M

  Japanese Journal of Pesticide Science, Feb. 2017, Peer-reviewed, Invited

  
• The morphogenesis-related NDR kinase pathway of Colletotrichum orbiculare is required for translating plant surface signals into infection-related morphogenesis and pathogenesis

  Sayo Kodama; Junya Ishizuka; Ito Miyashita; Takaaki Ishii; Takumi Nishiuchi; Hideto Miyoshi; Yasuyuki Kubo

  PLOS PATHOGENS, Feb. 2017, Peer-reviewed

  
• Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning

  Ryohei Yamagoshi; Takenori Yamamoto; Mitsuru Hashimoto; Ryohei Sugahara; Takahiro Shiotsuki; Hideto Miyoshi; Hiroshi Terada; Yasuo Shinohara

  MITOCHONDRION, Jan. 2017, Peer-reviewed

  
• Synthetic Ubiquinones Specifically Bind to Mitochondrial Voltage-Dependent Anion Channel 1 (VDAC1) in Saccharomyces cerevisiae Mitochondria

  Masatoshi Murai; Ayaka Okuda; Takenori Yamamoto; Yasuo Shinohara; Hideto Miyoshi

  BIOCHEMISTRY, Jan. 2017, Peer-reviewed

  
• Characterization of the reaction of decoupling ubiquinone with bovine mitochondrial respiratory complex I

  Takahiro Masuya; Kenji Okuda; Masatoshi Murai; Hideto Miyoshi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2016, Peer-reviewed

  
• Current topics on inhibitors of respiratory complex I

  Masatoshi Murai; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 2016, Peer-reviewed

  
• Current topics on inhibitors of respiratory complex I.

  Murai M; Miyoshi H

  Biochimica et biophysica acta, Jul. 2016, Peer-reviewed

  
• Mechanism for Remodeling of the Acyl Chain Composition of Cardiolipin Catalyzed by Saccharomyces cerevisiae Tafazzin

  Masato Abe; Yui Hasegawa; Masahide Oku; Yoshiki Sawada; Eriko Tanaka; Yasuyoshi Sakai; Hideto Miyoshi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2016, Peer-reviewed

  
• Specific Methylation of Asp160 (49 kDa subunit) Located inside the Quinone Binding Cavity of Bovine Mitochondrial Complex I

  Masatoshi Murai; Hiroyuki Inaoka; Takahiro Masuya; Shunsuke Aburaya; Wataru Aoki; Hideto Miyoshi

  BIOCHEMISTRY, Jun. 2016, Peer-reviewed

  
• 微生物二次代謝産物からのミトコンドリア標的にした農薬リード化合物の探索

  渡邊 善洋; 須賀 拓弥; 成沢 里美; 岩月 正人; 中島 琢自; 野中 健一; 塩月 孝博; 篠原 康雄; 一丸 直哉; 浅見 行弘; 三芳 秀人; 大村 智; 塩見 和朗

  日本薬学会年会要旨集, Mar. 2016, Peer-reviewed

  
• Characterization of two adenine nucleotide translocase paralogues in the stink bug, Plautia stali

  Sugahara Ryohei; Minaba Masaomi; Jouraku Akiya; Kotaki Toyomi; Yamamoto Takenori; Shinohara Yasuo; Miyoshi Hideto; Shiotsuki Takahiro

  Journal of Pesticide Science, 2016

  
• Reduction of Synthetic Ubiquinone QT Catalyzed by Bovine Mitochondria! Complex I Is Decoupled from Proton Translocation

  Kenji Okuda; Masatoshi Murai; Shunsuke Aburaya; Wataru Aoki; Hideto Miyoshi

  BIOCHEMISTRY, Jan. 2016, Peer-reviewed

  
• Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae

  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Omura; Kazuro Shiomi

  JOURNAL OF ANTIBIOTICS, Oct. 2015, Peer-reviewed

  
• Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I

  Masatoshi Murai; Sayako Habu; Sonomi Murakami; Takeshi Ito; Hideto Miyoshi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2015, Peer-reviewed

  
• Identification of the Binding Position of Amilorides in the Quinone Binding Pocket of Mitochondrial Complex I

  Takeshi Ito; Masatoshi Murai; Hironobu Morisaka; Hideto Miyoshi

  BIOCHEMISTRY, Jun. 2015, Peer-reviewed

  
• Amilorides Bind to the Quinone Binding Pocket of Bovine Mitochondrial Complex I

  Masatoshi Murai; Sonomi Murakami; Takeshi Ito; Hideto Miyoshi

  BIOCHEMISTRY, May 2015, Peer-reviewed

  
• Syntheses of photoreactive cardiolipins for a photoaffinity labeling study

  Masato Abe; Masaaki Nakano; Ayumi Kosaka; Hideto Miyoshi

  TETRAHEDRON LETTERS, Apr. 2015, Peer-reviewed

  
• Two Adenine Nucleotide Translocase Paralogues Involved in Cell Proliferation and Spermatogenesis in the Silkworm Bombyx mori

  Ryohei Sugahara; Akiya Jouraku; Takayo Nakakura; Takahiro Kusakabe; Takenori Yamamoto; Yasuo Shinohara; Hideto Miyoshi; Takahiro Shiotsuki

  PLOS ONE, Mar. 2015, Peer-reviewed

  
• Conserved Amino Acid Residues of the NuoD Segment Important for Structure and Function of Escherichia coli NDH-1 (Complex I)

  Prem Kumar Sinha; Norma Castro-Guerrero; Gaurav Patki; Motoaki Sato; Jesus Torres-Bacete; Subhash Sinha; Hideto Miyoshi; Akemi Matsuno-Yagi; Takao Yagi

  BIOCHEMISTRY, Jan. 2015, Peer-reviewed

  
• Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system

  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Yoshihiro Watanabe; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Omura; Kazuro Shiomi

  JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2015, Peer-reviewed

  
• Pinpoint Chemical Modification of Asp160 in the 49 kDa Subunit of Bovine Mitochondrial Complex I via a Combination of Ligand-Directed Tosyl Chemistry and Click Chemistry

  Takahiro Masuya; Masatoshi Mural; Hironobu Morisaka; Hideto Miyoshi

  BIOCHEMISTRY, Dec. 2014, Peer-reviewed

  
• Chemical modifications of respiratory complex I for structural and functional studies

  Masatoshi Murai; Hideto Miyoshi

  JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, Aug. 2014, Peer-reviewed

  
• Identification of the Binding Site of the Quinone-Head Group in Mitochondrial Coq10 by Photoaffinity Labeling

  Masatoshi Murai; Kohei Matsunobu; Sawako Kudo; Kentaro Ifuku; Makoto Kawamukai; Hideto Miyoshi

  BIOCHEMISTRY, Jun. 2014, Peer-reviewed

  
• Site-Specific Chemical Labeling of Mitochondrial Respiratory Complex I through Ligand-Directed Tosylate Chemistry

  Takahiro Masuya; Masatoshi Murai; Kentaro Ifuku; Hironobu Morisaka; Hideto Miyoshi

  BIOCHEMISTRY, Apr. 2014, Peer-reviewed

  
• Critical role of a methyl group on the gamma-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I

  Naoto Kojima; Masato Abe; Yuki Suga; Kazufumi Ohtsuki; Tetsuaki Tanaka; Hiroki Iwasaki; Masayuki Yamashita; Hideto Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2013, Peer-reviewed

  
• Antimycin A-like molecules inhibit cyclic electron transport around photosystem I in ruptured chloroplasts

  Yoshichika Taira; Yuki Okegawa; Kazuhiko Sugimoto; Masato Abe; Hideto Miyoshi; Toshiharu Shikanai

  FEBS OPEN BIO, 2013, Peer-reviewed

  
• Fenpyroximate Binds to the Interface between PSST and 49 kDa Subunits in Mitochondrial NADH-Ubiquinone Oxidoreductase

  Yusuke Shiraishi; Masatoshi Murai; Naoto Sakiyama; Kentaro Ifuku; Hideto Miyoshi

  BIOCHEMISTRY, Mar. 2012, Peer-reviewed

  
• Current topics of the inhibitors of mitochondrial Complex I

  Hideto Miyoshi

  A Structural Perspective on Respiratory Complex I: Structure and Function of NADH: Ubiquinone Oxidoreductase, 01 Jan. 2012, Peer-reviewed

  
• Localization of Ubiquinone-8 in the Na+-pumping NADH: Quinone Oxidoreductase from Vibrio cholerae

  Marco S. Casutt; Ruslan Nedielkov; Severin Wendelspiess; Sara Vossler; Uwe Gerken; Masatoshi Murai; Hideto Miyoshi; Heiko M. Moeller; Julia Steuber

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2011, Peer-reviewed

  
• Molecular Mechanisms for the Induction of Peroxidase Activity of the Cytochrome c-Cardiolipin Complex

  Masato Abe; Ryota Niibayashi; Shinya Koubori; Ikuko Moriyama; Hideto Miyoshi

  BIOCHEMISTRY, Oct. 2011, Peer-reviewed

  
• Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase

  S. Nakanishi; M. Abe; S. Yamamoto; M. Murai; H. Miyoshi

  Biochimica et Biophysica Acta - Bioenergetics, Sep. 2011, Peer-reviewed

  
• Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase

  Sayo Nakanishi; Masato Abe; Shuhei Yamamoto; Masatoshi Murai; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Sep. 2011, Peer-reviewed

  
• Exploring Interactions between the 49 kDa and ND1 Subunits in Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) by Photoaffinity Labeling

  Masatoshi Murai; Yuko Mashimo; Judy Hirst; Hideto Miyoshi

  BIOCHEMISTRY, Aug. 2011, Peer-reviewed

  
• Synthesis and characterization of photoaffinity probe of acetogenin, a strong inhibitor of mitochondrial complex I

  Shuhei Yamamoto; Masato Abe; Sayo Nakanishi; Masatoshi Murai; Hideto Miyoshi

  TETRAHEDRON LETTERS, Jun. 2011, Peer-reviewed

  
• Reaction Mechanism of Single Subunit NADH-Ubiquinone Oxidoreductase (Ndi1) from Saccharomyces cerevisiae EVIDENCE FOR A TERNARY COMPLEX MECHANISM

  Yu Yang; Tetsuo Yamashita; Eiko Nakamaru-Ogiso; Takeshi Hashimoto; Masatoshi Murai; Junsuke Igarashi; Hideto Miyoshi; Nozomu Mori; Akemi Matsuno-Yagi; Takao Yagi; Hiroaki Kosaka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2011, Peer-reviewed

  
• New insight into mechanism of ROS suppression in single subunit NADH-ibiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae

  YAMASHITA TETSUO; Yu Yang; Eiko Nakamaru-Ogiso; HASHIMOTO Takeshi; Masatoshi Murai; IGARASHI Junsuke; Hideto Miyoshi; Akemi Matsuno-Yagi; Takao Yagi; KOSAKA Hiroaki

  The Journal of Physiological Sciences, Mar. 2011, Peer-reviewed

  
• Synthesis of Annonaceous Acetogenins and Their Inhibitory Action with Mitochondrial Complex I

  Yasunao Hattori; Hiroyuki Konno; Hideto Miyoshi; Hidefumi Makabe

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Feb. 2011, Peer-reviewed

  
• Exploring the Binding Site of Delta lac-Acetogenin in Bovine Heart Mitochondrial NADH-Ubiquinone Oxidoreductase

  Nobuyuki Kakutani; Masatoshi Murai; Naoto Sakiyama; Hideto Miyoshi

  BIOCHEMISTRY, Jun. 2010, Peer-reviewed

  
• Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain

  Andrew M. James; Helena M. Cocheme; Masatoshi Murai; Hideto Miyoshi; Michael P. Murphy

  FEBS JOURNAL, May 2010, Peer-reviewed

  
• Concise procedure for the synthesis of cardiolipins having different fatty acid combinations

  Masato Abe; Shigeki Kitsuda; Shunji Ohyama; Shinya Koubori; Masatoshi Murai; Hideto Miyoshi

  TETRAHEDRON LETTERS, Apr. 2010, Peer-reviewed

  
• Characterization of the Ubiquinone Binding Site in the Alternative NADH-Quinone Oxidoreductase of Saccharomyces cerevisiae by Photoaffinity Labeling

  Masatoshi Murai; Tetsuo Yamashita; Mai Senoh; Yuko Mashimo; Michihiko Kataoka; Hiroaki Kosaka; Akemi Matsuno-Yagi; Takao Yagi; Hideto Miyoshi

  BIOCHEMISTRY, Apr. 2010, Peer-reviewed

  
• Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II

  Madhavi P. Paranagama; Kimitoshi Sakamoto; Hisako Amino; Mutsumi Awano; Hideto Miyoshi; Kiyoshi Kita

  MITOCHONDRION, Mar. 2010, Peer-reviewed

  
• Exploring the binding site of acetogenin in the ND1 subunit of bovine mitochondrial complex I

  K. Sekiguchi; M. Murai; H. Miyoshi

  Biochimica et Biophysica Acta - Bioenergetics, Sep. 2009, Peer-reviewed

  
• Exploring the binding site of acetogenin in the ND1 subunit of bovine mitochondrial complex I

  Koji Sekiguchi; Masatoshi Murai; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Sep. 2009, Peer-reviewed

  
• Accumulation of hydroxycinnamic acid amides induced by pathogen infection and identification of agmatine coumaroyltransferase in Arabidopsis thaliana

  Atsushi Muroi; Atsushi Ishihara; Chihiro Tanaka; Akihiro Ishizuka; Junji Takabayashi; Hideto Miyoshi; Takaaki Nishioka

  PLANTA, Aug. 2009, Peer-reviewed

  
• Biochemical and Spectroscopic Properties of Cyanide-Insensitive Quinol Oxidase from Gluconobacter oxydans

  Tatsushi Mogi; Yoshitaka Ano; Tomoko Nakatsuka; Hirohide Toyama; Atsushi Muroi; Hideto Miyoshi; Catharina T. Migita; Hideaki Ui; Kazuro Shiomi; Satoshi Omura; Kiyoshi Kita; Kazunobu Matsushita

  JOURNAL OF BIOCHEMISTRY, Aug. 2009, Peer-reviewed

  
• Properties of Cytochrome bd Plastoquinol Oxidase from the Cyanobacterium Synechocystis sp PCC 6803

  Tatsushi Mogi; Hideto Miyoshi

  JOURNAL OF BIOCHEMISTRY, Mar. 2009, Peer-reviewed

  
• Characterization of the Inhibitor Binding Site in Mitochondrial NADH-Ubiquinone Oxidoreductase by Photoaffinity Labeling Using a Quinazoline-Type Inhibitor

  Masatoshi Murai; Koji Sekiguchi; Takaaki Nishioka; Hideto Miyoshi

  BIOCHEMISTRY, Feb. 2009, Peer-reviewed

  
• Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases

  T. Mogi; H. Ui; K. Shiomi; S. Omura; H. Miyoshi; K. Kita

  Biochimica et Biophysica Acta - Bioenergetics, Feb. 2009, Peer-reviewed

  
• Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii

  Kenji Kawahara; Tatsushi Mogi; Takeshi Q. Tanaka; Masayuki Hata; Hideto Miyoshi; Kiyoshi Kita

  JOURNAL OF BIOCHEMISTRY, Feb. 2009, Peer-reviewed

  
• Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II)

  Tatsushi Mogi; Kazunobu Matsushita; Yoshiro Murase; Kenji Kawahara; Hideto Miyoshi; Hideaki Ui; Kazuro Shiomi; Satoshi Omura; Kiyoshi Kita

  FEMS MICROBIOLOGY LETTERS, Feb. 2009, Peer-reviewed

  
• Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases

  T. Mogi; H. Ui; K. Shiomi; S. Omura; H. Miyoshi; K. Kita

  Biochim. Biophys. Acta – Bioenerg., Feb. 2009, Peer-reviewed

  
• Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I)

  Naoya Ichimaru; Masatoshi Murai; Nobuyuki Kakutani; Junko Kako; Atsushi Ishihara; Yoshiaki Nakagawa; Takaaki Nishioka; Takao Yagi; Hideto Miyoshi

  BIOCHEMISTRY, Oct. 2008, Peer-reviewed

  
• A Tightly Bound Quinone Functions in the Ubiquinone Reaction Sites of Quinoprotein Alcohol Dehydrogenase of an Acetic Acid Bacterium, Gluconobacter suboxydans

  Kazunobu Matsushita; Yoshiki Kobayashi; Mitsuhiro Mizuguchi; Hirohide Toyama; Osao Adachi; Kimitoshi Sakamoto; Hideto Miyoshi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2008, Peer-reviewed

  
• Identification of receptors of main sex-pheromone components of three Lepidopteran species

  Hidefumi Mitsuno; Takeshi Sakurai; Masatoshi Murai; Tetsuya Yasuda; Soichi Kugimiya; Rika Ozawa; Haruhiko Toyohara; Junji Takabayashi; Hideto Miyoshi; Takaaki Nishioka

  EUROPEAN JOURNAL OF NEUROSCIENCE, Sep. 2008, Peer-reviewed

  
• Current topics of organic and biological chemistry of annonaceous acetogenins and their synthetic mimics

  Hidefumi Makabe; Hiroyuki Konno; Hideto Miyoshi

  Current Drug Discovery Technologies, Sep. 2008, Peer-reviewed

  
• Synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex I

  Shin-ichi Furuhata; Yasunao Hattori; Motonori Okajima; Hiroyuki Konno; Masato Abe; Hideto Miyoshi; Tetsuhisa Goto; Hidefumi Makabe

  TETRAHEDRON, Aug. 2008, Peer-reviewed

  
• Dynamic function of the spacer region of acetogenins in the inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I)

  Masato Abe; Akina Kubo; Shuhei Yamamoto; Yoshinori Hatoh; Masatoshi Murai; Yasunao Hattori; Hidefumi Makabe; Takaaki Nishioka; Hideto Miyoshi

  BIOCHEMISTRY, Jun. 2008, Peer-reviewed

  
• Synthesis of pyranicin and its inhibitory action with bovine heart mitochondrial complex I

  Yasunao Hattori; Shin-ichi Furuhata; Motonori Okajima; Hiroyuki Konno; Masato Abe; Hideto Miyoshi; Tetsuhisa Goto; Hidefumi Makabe

  ORGANIC LETTERS, Mar. 2008, Peer-reviewed

  
• Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis

  Jun Matsumoto; Kimitoshi Sakamoto; Noriko Shinjyo; Yasutoshi Kido; Nao Yamamoto; Kinpei Yagi; Hideto Miyoshi; Nariaki Nonaka; Ken Katakura; Kiyoshi Kita; Yuzaburo Oku

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 2008, Peer-reviewed

  
• Crucial structural factors and mode of action of polyene Amides as inhibitors for mitochondrial NADH-Ubiquinone oxidoreductase (Complex I)

  Takehiko Yoshida; Masatoshi Murai; Masato Abe; Naoya Ichimaru; Toshiyuki Harada; Takaaki Nishioka; Hideto Miyoshi

  BIOCHEMISTRY, Sep. 2007, Peer-reviewed

  
• Synthesis and Inhibitory Action of Novel Acetogenin Mimics Δlac-Acetogenins: A New Class of Inhibitors of Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex-I)

  Hideto Miyoshi; Naoya Ichimaru; Masatoshi Murai

  Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety, 31 May 2007, Peer-reviewed

  
• The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I

  Masatoshi Murai; Atsushi Ishihara; Takaaki Nishioka; Takao Yagi; Hideto Miyoshi

  BIOCHEMISTRY, May 2007, Peer-reviewed

  
• Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I

  Yasunao Hattori; Hiroyuki Konno; Masato Abe; Hideto Miyoshi; Tetsuhisa Goto; Hidefumi Makabe

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2007, Peer-reviewed

  
• Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae

  Tetsuo Yamashita; Eiko Nakamaru-Ogiso; Hideto Miyoshi; Akemi Matsuno-Yagi; Takao Yagi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2007, Peer-reviewed

  
• Glutamate 107 in subunit I of the cytochrome bd quinol oxidase from Escherichia coli is protonated and near the heme d/heme b(595) binuclear center

  Ke Yang; Jie Zhang; Ahmet S. Vakkasoglu; Ruth Hielscher; Jeffrey P. Osborne; James Hemp; Hideto Miyoshi; Petra Hellwig; Robert B. Gennis

  BIOCHEMISTRY, Mar. 2007, Peer-reviewed

  
• Effect of stereochemistry of Delta lac-acetogenins on the inhibition of mitochondrial complex I (NADH-ubiquinone oxidoreductase)

  Naoya Ichimaru; Naoko Yoshinaga; Takaaki Nishioka; Hideto Miyoshi

  TETRAHEDRON, Jan. 2007, Peer-reviewed

  
• Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp FKI-1083

  Hideaki Ui; Kazuro Shiomi; Hideaki Suzuki; Hiroko Hatano; Hiromi Morimoto; Yuichi Yamaguchi; Rokuro Masuma; Toshiaki Sunazuka; Hiroyuki Shimamura; Kimitoshi Sakamoto; Kiyoshi Kita; Hideto Miyoshi; Hiroshi Tomoda; Satoshi Omura

  JOURNAL OF ANTIBIOTICS, Dec. 2006, Peer-reviewed

  
• Glutamates 99 and 107 in transmembrane helix III of subunit I of cytochrome bd are critical for binding of the heme b(595)-d binuclear center and enzyme activity

  Tatsushi Mogi; Sachiko Endou; Satoru Akimoto; Mayumi Morimoto-Tadokoro; Hideto Miyoshi

  BIOCHEMISTRY, Dec. 2006, Peer-reviewed

  
• Synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin and their inhibitory action with bovine heart mitochondrial complex I

  Yasunao Hattori; Yuka Kimura; Aki Moroda; Hiroyuki Konno; Masato Abe; Hideto Miyoshi; Tetsuhisa Goto; Hidefumi Makabe

  CHEMISTRY-AN ASIAN JOURNAL, Dec. 2006, Peer-reviewed

  
• Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550

  Hideaki Ui; Kazuro Shiomi; Hideaki Suzuki; Hiroko Hatano; Hiromi Morimoto; Yuichi Yamaguchi; Rokuro Masuma; Kimitoshi Sakamoto; Kiyoshi Kita; Hideto Miyoshi; Hiroshi Tomoda; Haruo Tanaka; Satoshi Omura

  JOURNAL OF ANTIBIOTICS, Sep. 2006, Peer-reviewed

  
• Mode of inhibitory action of Delta lac-acetogenins, a new class of inhibitors of bovine heart mitochondrial complex I

  Masatoshi Murai; Naoya Ichimaru; Masato Abe; Takaaki Nishioka; Hideto Miyoshi

  BIOCHEMISTRY, Aug. 2006, Peer-reviewed

  
• Function of the alkyl side chains of Delta lac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase)

  N Ichimaru; M Abe; M Murai; M Senoh; T Nishioka; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2006, Peer-reviewed

  
• Probing the ubiquinol-binding site in cytochrome bd by site-directed mutagenesis

  T Mogi; S Akimoto; S Endou; T Watanabe-Nakayama; E Mizuochi-Asai; H Miyoshi

  BIOCHEMISTRY, Jun. 2006, Peer-reviewed

  
• Light control of mitochondrial complex I activity by a photoresponsive inhibitor

  D Fujita; M Murai; T Nishioka; H Miyoshi

  BIOCHEMISTRY, May 2006, Peer-reviewed

  
• Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I

  H Makabe; Y Kimura; M Higuchi; H Konno; M Murai; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY, May 2006, Peer-reviewed

  
• Kinetic mechanism of quinol oxidation by cytochrome bd studied with ubiquinone-2 analogs

  Y Matsumoto; E Muneyuki; D Fujita; K Sakamoto; H Miyoshi; M Yoshida; T Mogi

  JOURNAL OF BIOCHEMISTRY, Apr. 2006, Peer-reviewed

  
• Synthesis of photolabile Delta lac-acetogenin for lphotoaffinity labeling of mitochondrial complex I

  M Murai; N Ichimaru; M Abe; T Nishioka; H Miyoshi

  JOURNAL OF PESTICIDE SCIENCE, 2006, Peer-reviewed

  
• Mass spectrometric analysis of the ubiquinol-binding site in cytochrome bd from Escherichia coli

  Y Matsumoto; M Murai; D Fujita; K Sakamoto; H Miyoshi; M Yoshida; T Mogi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2006, Peer-reviewed

  
• Dynamic function of the alkyl spacer of acetogenins in their inhibitory action with mitochondrial complex I (NADH-ubiquinone oxidoreductase)

  M Abe; M Murai; N Ichimaru; A Kenmochi; T Yoshida; A Kubo; Y Kimura; A Moroda; H Makabe; T Nishioka; H Miyoshi

  BIOCHEMISTRY, Nov. 2005, Peer-reviewed

  
• Synthesis of non-THF analogs of acetogenin toward simplified mimics

  D Fujita; N Ichimaru; M Abe; M Murai; T Hamada; T Nishioka; H Miyoshi

  TETRAHEDRON LETTERS, Aug. 2005, Peer-reviewed

  
• Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin

  H Makabe; M Higuchi; H Konno; M Murai; H Miyoshi

  TETRAHEDRON LETTERS, Jul. 2005, Peer-reviewed

  
• Characterization of the membrane domain subunit NuoJ (ND6) of the NADH-quinone oxidoreductase from Escherichia coli by chromosomal DNA manipulation

  MC Kao; S Di Bernardo; E Nakamaru-Ogiso; H Miyoshi; A Matsuno-Yagi; T Yagi

  BIOCHEMISTRY, Mar. 2005, Peer-reviewed

  
• A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I

  K Shiomi; H Ui; H Suzuki; H Hatano; T Nagamitsu; D Takano; H Miyadera; T Yamashita; K Kita; H Miyoshi; A Harder; H Tomoda; S Omura

  JOURNAL OF ANTIBIOTICS, Jan. 2005, Peer-reviewed

  
• Inhibitors of mitochondrial respiratory enzymes

  H Miyoshi

  JOURNAL OF PESTICIDE SCIENCE, 2005, Peer-reviewed

  
• Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I

  N Ichimaru; M Murai; M Abe; T Hamada; Y Yamada; S Makino; T Nishioka; H Makabe; A Makino; T Kobayashi; H Miyoshi

  BIOCHEMISTRY, Jan. 2005, Peer-reviewed

  
• A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I

  K Shiomi; H Ui; H Suzuki; H Hatano; T Nagamitsu; D Takano; H Miyadera; T Yamashita; K Kita; H Miyoshi; A Harder; H Tomoda; S Omura

  JOURNAL OF ANTIBIOTICS, Jan. 2005, Peer-reviewed

  
• Total synthesis of cis-solamin and its inhibitory action with bovine heart mitochondrial complex I

  H Makabe; Y Hattori; Y Kimura; H Konno; M Abe; H Miyoshi; A Tanaka; T Oritani

  TETRAHEDRON, Nov. 2004, Peer-reviewed

  
• Direct evidence for the interaction of stigmatellin with a protonated acidic group in the bc(1) complex from Saccharomyces cerevisiae as monitored by FTIR difference spectroscopy and C-13 specific labeling

  M Ritter; H Palsdottir; M Abe; W Mantele; C Hunte; H Miyoshi; P Hellwig

  BIOCHEMISTRY, Jul. 2004, Peer-reviewed

  
• Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I

  T Hamada; N Ichimaru; M Abe; D Fujita; A Kenmochi; T Nishioka; K Zwicker; U Brandt; H Miyoshi

  BIOCHEMISTRY, Mar. 2004, Peer-reviewed

  
• Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum

  T. Yamashita; T. Ino; H. Miyoshi; K. Sakamoto; A. Osanai; E. Nakamaru-Ogiso; K. Kita

  Biochimica et Biophysica Acta - Bioenergetics, Feb. 2004, Peer-reviewed

  
• Essential structural features of acetogenins: role of hydroxy groups adjacent to the bis-THF rings

  M Abe; A Kenmochi; N Ichimaru; T Hamada; T Nishioka; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 2004, Peer-reviewed

  
• Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue

  H Konno; N Hiura; H Makabe; M Abe; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 2004, Peer-reviewed

  
• Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum

  T Yamashita; T Ino; H Miyoshi; K Sakamoto; A Osanai; E Nakamaru-Ogiso; K Kita

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Feb. 2004, Peer-reviewed

  
• DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation

  K Inaba; YH Takahashi; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2004, Peer-reviewed

  
• Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue

  H Konno; N Hiura; H Makabe; M Abe; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 2004, Peer-reviewed

  
• Synthesis of two possible diastereomers of reticulatain-1

  H Makabe; A Miyawaki; R Takahashi; Y Hattori; H Konno; M Abe; H Miyoshi

  TETRAHEDRON LETTERS, Jan. 2004, Peer-reviewed

  
• Occurrence of a bound ubiquinone and its function in Escherichia coli membrane-bound quinoprotein glucose dehydrogenase

  MD Elias; S Nakamura; CT Migita; H Miyoshi; H Toyama; K Matsushita; O Adachi; M Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2004, Peer-reviewed

  
• Erratum: DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation (Journal of Biological Chemistry (2004) 279 (6761-6768))

  K. Inaba; Y.-H. Takahashi; N. Fujieda; K. Kano; H. Miyoshi; K. Ito

  Journal of Biological Chemistry, 2004, Peer-reviewed

  
• Synthesis of C-13-labeled ubiquinone-acetogenin hybrid inhibitors of mitochondrial complex I

  N Ichimaru; M Abe; A Kenmochi; T Hamada; T Nishioka; H Miyoshi

  JOURNAL OF PESTICIDE SCIENCE, 2004, Peer-reviewed

  
• Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor

  T. Ino; T. Nishioka; H. Miyoshi

  Biochimica et Biophysica Acta - Bioenergetics, Aug. 2003, Peer-reviewed

  
• Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor

  T Ino; T Nishioka; H Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Aug. 2003, Peer-reviewed

  
• Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I

  H Yabunaka; M Abe; A Kenmochi; T Hamada; T Nishioka; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2003, Peer-reviewed

  
• Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm

  A Adachi; N Shinjyo; D Fujita; H Miyoshi; H Amino; Y Watanabe; K Kita

  FEBS LETTERS, May 2003, Peer-reviewed

  
• Asymmetric binding of the high-affinity Q(H)(center dot-) ubisemiquinone in quinol oxidase (bo(3)) from Escherichia coli studied by multifrequency electron paramagnetic resonance spectroscopy

  S Grimaldi; T Ostermann; N Weiden; T Mogi; H Miyoshi; B Ludwig; H Michel; TF Prisner; F MacMillan

  BIOCHEMISTRY, May 2003, Peer-reviewed

  
• Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria

  H Amino; A Osanai; H Miyadera; N Shinjyo; E Tomitsuka; H Taka; R Mineki; K Murayama; S Takamiya; T Aoki; H Miyoshi; K Sakamoto; S Kojima; K Kita

  MOLECULAR AND BIOCHEMICAL PARASITOLOGY, May 2003, Peer-reviewed

  
• Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm

  A Adachi; N Shinjyo; D Fujita; H Miyoshi; H Amino; Y Watanabe; K Kita

  FEBS LETTERS, May 2003, Peer-reviewed

  
• Complex II from phototrophic purple bacterium Rhodoferax fermentans displays rhodoquinol-fumarate reductase activity

  H Miyadera; A Hiraishi; H Miyoshi; K Sakamoto; R Mineki; K Murayama; KVP Nagashima; K Matsuura; S Kojima; K Kita

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Apr. 2003, Peer-reviewed

  
• Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)

  Hiroko Miyadera; Kazuro Shiomi; Hideaki Ui; Yuichi Yamaguchi; Rokuro Masuma; Hiroshi Tomoda; Hideto Miyoshi; Arihiro Osanai; Kiyoshi Kita; Satoshi Omura

  Proceedings of the National Academy of Sciences of the United States of America, 21 Jan. 2003, Peer-reviewed

  
• Architecture of succinate dehydrogenase and reactive oxygen species generation

  Yankovskaya, V; R Horsefield; S Tornroth; C Luna-Chavez; H Miyoshi; C Leger; B Byrne; G Cecchini; S Iwata

  SCIENCE, Jan. 2003, Peer-reviewed

  
• The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I

  E Nakamaru-Ogiso; K Sakamoto; A Matsuno-Yagi; H Miyoshi; T Yagi

  BIOCHEMISTRY, Jan. 2003, Peer-reviewed

  
• Hybrid ubiquinone: Novel inhibitor of mitochondrial complex I

  H. Yabunaka; A. Kenmochi; Y. Nakatogawa; K. Sakamoto; H. Miyoshi

  Biochimica et Biophysica Acta - Bioenergetics, Dec. 2002, Peer-reviewed

  
• Hybrid ubiquinone: novel inhibitor of mitochondrial complex I

  H Yabunaka; A Kenmochi; Y Nakatogawa; K Sakamoto; H Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Dec. 2002, Peer-reviewed

  
• Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I

  T Motoyama; H Yabunaka; H Miyoshi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2002, Peer-reviewed

  
• Regulation of the mitochondrial permeability transition pore by ubiquinone analogs. A progress report

  L Walter; H Miyoshi; Leverve, X; P Bernardi; E Fontaine

  FREE RADICAL RESEARCH, Apr. 2002, Peer-reviewed

  
• Quinones in long-lived clk-1 mutants of Caenorhabditis elegans

  H Miyadera; K Kano; H Miyoshi; N Ishii; S Hekimi; K Kita

  FEBS LETTERS, Feb. 2002, Peer-reviewed

  
• Quinones in long-lived clk-1 mutants of Caenorhabditis elegans

  H Miyadera; K Kano; H Miyoshi; N Ishii; S Hekimi; K Kita

  FEBS LETTERS, Feb. 2002, Peer-reviewed

  
• Synthesis and electron-transfer activity of azido ubiquinone-2

  K Sakamoto; K Nomura; H Miyoshi

  JOURNAL OF PESTICIDE SCIENCE, 2002, Peer-reviewed

  
• The biochemical mode of action of the novel selective fungicide cyazofamid: Specific inhibition of mitochondrial complex III in Phythium spinosum

  S Mitani; S Araki; Y Takii; T Ohshima; N Matsuo; H Miyoshi

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Oct. 2001, Peer-reviewed

  
• Probing the ubiquinone reduction site in bovine mitochondrial complex I using a series of synthetic ubiquinones and inhibitors

  H Miyoshi

  JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, Jun. 2001, Peer-reviewed

  
• Parasite mitochondria as a target for chemotherapy

  K Kita; H Miyadera; F Saruta; H Miyoshi

  JOURNAL OF HEALTH SCIENCE, Jun. 2001, Peer-reviewed

  
• An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria

  Satoshi Omura; Hiroko Miyadera; Hideaki Ui; Kazuro Shiomi; Yuuichi Yamaguchi; Rokuro Masuma; Tohru Nagamitsu; Daisuke Takano; Toshiaki Sunazuka; Achim Harder; Heinz Kölbl; Michio Namikoshi; Hideto Miyoshi; Kimitoshi Sakamoto; Kiyoshi Kita

  Proceedings of the National Academy of Sciences of the United States of America, 02 Jan. 2001

  
• Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I

  M Takada; K Kuwabara; H Nakato; A Tanaka; H Iwamura; H Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Nov. 2000, Peer-reviewed

  
• Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics

  K Kuwabara; M Takada; J Iwata; K Tatsumoto; K Sakamoto; H Iwamura; H Miyoshi

  EUROPEAN JOURNAL OF BIOCHEMISTRY, May 2000, Peer-reviewed

  
• Vibrational modes of ubiquinone in cytochrome bo(3) from Escherichia coli identified by Fourier transform infrared difference spectroscopy and specific C-13 labeling

  P Hellwig; T Mogi; FL Tomson; RB Gennis; J Iwata; H Miyoshi; W Mantele

  BIOCHEMISTRY, Nov. 1999, Peer-reviewed

  
• Origin of selective inhibition of mitochondrial complex I by pyridinium-type inhibitor MP-24

  J Iwata; H Miyoshi; H Iwamura

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Oct. 1999, Peer-reviewed

  
• Role of a bound ubiquinone on reactions of the Escherichia coli cytochrome bo with ubiquinol and dioxygen

  T Mogi; M Sato-Watanabe; H Miyoshi; Y Orii

  FEBS LETTERS, Aug. 1999, Peer-reviewed

  
• UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp 517-02 V. Inhibition mechanism of bovine heart mitochondrial cytochrome bc(1) by the novel antibiotic UK-2A

  K Machida; H Takimoto; H Miyoshi; M Taniguchi

  JOURNAL OF ANTIBIOTICS, Aug. 1999, Peer-reviewed

  
• Role of a bound ubiquinone on reactions of the Escherichia coli cytochrome bo with ubiquinol and dioxygen

  T Mogi; M Sato-Watanabe; H Miyoshi; Y Orii

  FEBS LETTERS, Aug. 1999, Peer-reviewed

  
• Topographical characterization of the ubiquinone reduction site of glucose dehydrogenase in Escherichia coli using depth-dependent fluorescent inhibitors

  H Miyoshi; Y Niitome; K Matsushita; M Yamada; H Iwamura

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, May 1999, Peer-reviewed

  
• Characterization of the ubiquinol oxidation sites in cytochromes bo and bd from Escherichia coli using aurachin C analogues

  H Miyoshi; K Takegami; K Sakamoto; T Mogi; H Iwamura

  JOURNAL OF BIOCHEMISTRY, Jan. 1999, Peer-reviewed

  
• The quinohemoprotein alcohol dehydrogenase of Gluconobacter suboxydans has ubiquinol oxidation activity at a site different from the ubiquinone reduction site

  K Matsushita; T Yakushi; H Toyama; O Adachi; H Miyoshi; E Tagami; K Sakamoto

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jan. 1999, Peer-reviewed

  
• Role of the isoprenyl tail of ubiquinone in reaction with respiratory enzymes: Studies with bovine heart mitochondrial complex I and Escherichia coli bo-type ubiquinol oxidase

  K Sakamoto; H Miyoshi; M Ohshima; K Kuwabara; K Kano; T Akagi; T Mogi; H Iwamura

  BIOCHEMISTRY, Oct. 1998, Peer-reviewed

  
• Isolation and characterizations of quinone analogue-resistant mutants of bo-type ubiquinol oxidase from Escherichia coli

  M Sato-Watanabe; T Mogi; K Sakamoto; H Miyoshi; Y Anraku

  BIOCHEMISTRY, Sep. 1998, Peer-reviewed

  
• Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I

  H Miyoshi; M Ohshima; H Shimada; T Akagi; H Iwamura; JL McLaughlin

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 1998, Peer-reviewed

  
• Specificity of pyridinium inhibitors of the ubiquinone reduction sites in mitochondrial complex I

  H Miyoshi; J Iwata; K Sakamoto; H Furukawa; M Takada; H Iwamura; T Watanabe; Y Kodama

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1998, Peer-reviewed

  
• Structure-activity relationships of some complex I inhibitors

  H Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, May 1998, Peer-reviewed

  
• Characterization of the ubiquinone reduction site of mitochondrial complex I using bulky synthetic ubiquinones

  M Ohshima; H Miyoshi; K Sakamoto; K Takegami; J Iwata; K Kuwabara; H Iwamura; T Yagi

  BIOCHEMISTRY, May 1998, Peer-reviewed

  
• Characterization and functional role of the Q(H) site of bo-type ubiquinol oxidase from Escherichia coli

  M Sato-Watanabe; T Mogi; H Miyoshi; Y Anraku

  BIOCHEMISTRY, Apr. 1998, Peer-reviewed

  
• Respiratory inhibition of acaricide AKD-2023 and its deacetyl metabolite

  Y Koura; S Kinoshita; K Takasuka; S Koura; N Osaki; S Matsumoto; H Miyoshi

  JOURNAL OF PESTICIDE SCIENCE, 1998, Peer-reviewed

  
• Cooperation of two quinone-binding sites in the oxidation of substrates by cytochrome bo

  M Sato-Watanabe; T Mogi; H Miyoshi; Y Anraku

  OXYGEN HOMEOSTASIS AND ITS DYNAMICS, 1998, Peer-reviewed

  
• Specific interaction of cytokinins and their analogs with rotenone-sensitive internal NADH dehydrogenase in potato tuber mitochondria

  M Sue; H Miyoshi; H Iwamura

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 1997, Peer-reviewed

  
• Probing the ubiquinone reduction site of mitochondrial complex I using novel cationic inhibitors

  H Miyoshi; M Inoue; S Okamoto; M Ohshima; K Sakamoto; H Iwamura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1997, Peer-reviewed

  
• Probing substrate binding site of the Escherichia coli quinol oxidases using synthetic ubiquinol analogues

  K Sakamoto; H Miyoshi; K Takegami; T Mogi; Y Anraku; H Iwamura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1996, Peer-reviewed

  
• Structural factors of rotenone required for inhibition of various NADH-ubiquinone oxidoreductases

  H Ueno; H Miyoshi; M Inoue; Y Niidome; H Iwamura

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Sep. 1996, Peer-reviewed

  
• Inhibitor probes of the quinone binding sites of mammalian complex II and Escherichia coli fumarate reductase

  Yankovskaya, V; SO Sablin; RR Ramsay; TP Singer; BAC Ackrell; G Cecchini; H Miyoshi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1996, Peer-reviewed

  
• Direct interaction between mitochondrial succinate-ubiquinone and ubiquinol-cytochrome c oxidoreductases probed by sensitivity to quinone-related inhibitors

  A Yamashita; H Miyoshi; T Hatano; H Iwamura

  JOURNAL OF BIOCHEMISTRY, Aug. 1996, Peer-reviewed

  
• Comparison of the structural features of ubiquinone reduction sites between glucose dehydrogenase in Escherichia coli and bovine heart mitochondrial complex I

  K Sakamoto; H Miyoshi; K Matsushita; M Nakagawa; J Ikeda; M Ohshima; O Adachi; T Akagi; H Iwamura

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Apr. 1996, Peer-reviewed

  
• Uncoupling mechanism of glycoside antibiotic aculeximycin in isolated rat-liver mitochondria

  H Miyoshi; M Tamaki; H Murata; T Ikemoto; T Shibuya; K Harada; M Suzuki; H Iwamura

  JOURNAL OF BIOCHEMISTRY, Feb. 1996, Peer-reviewed

  
• Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases

  T Satoh; H Miyoshi; K Sakamoto; H Iwamura

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jan. 1996, Peer-reviewed

  
• Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase

  CH Lim; H Ueno; H Miyoshi; H Miyagawa; H Iwamura; T Ueno

  JOURNAL OF PESTICIDE SCIENCE, 1996, Peer-reviewed

  
• STABILIZATION OF A SEMIQUINONE RADICAL AT THE HIGH-AFFINITY QUINONE-BINDING SITE (Q(H)) OF THE ESCHERICHIA-COLI BO-TYPE UBIQUINOL OXIDASE

  M SATOWATANABE; S ITOH; T MOGI; K MATSUURA; H MIYOSHI; Y ANRAKU

  FEBS LETTERS, Oct. 1995, Peer-reviewed

  
• A MODEL OF ANTIMYCIN-A BINDING BASED ON STRUCTURE-ACTIVITY STUDIES OF SYNTHETIC ANTIMYCIN-A ANALOGS

  H MIYOSHI; N TOKUTAKE; Y IMAEDA; T AKAGI; H IWAMURA

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Apr. 1995, Peer-reviewed

  
• IDENTIFICATION OF A NOVEL QUINONE-BINDING SITE IN THE CYTOCHROME BO COMPLEX FROM ESCHERICHIA-COLI

  M SATOWATANABE; T MOGI; T OGURA; T KITAGAWA; H MIYOSHI; H IWAMURA; Y ANRAKU

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1994, Peer-reviewed

  
• STRUCTURE-FUNCTION STUDIES ON THE UBIQUINOL OXIDATION SITE OF THE CYTOCHROME BO COMPLEX FROM ESCHERICHIA-COLI USING P-BENZOQUINONES AND SUBSTITUTED PHENOLS

  M SATOWATANABE; T MOGI; H MIYOSHI; H IWAMURA; K MATSUSHITA; O ADACHI; Y ANRAKU

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1994, Peer-reviewed

  
• COMPARISON OF THE INHIBITORY-ACTION OF NATURAL ROTENONE AND ITS STEREOISOMERS WITH VARIOUS NADH-UBIQUINONE REDUCTASES

  H UENO; H MIYOSHI; K EBISUI; H IWAMURA

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Oct. 1994, Peer-reviewed

  
• STRUCTURAL FACTORS OF ANTIMYCIN-A MOLECULE REQUIRED FOR INHIBITORY-ACTION

  N TOKUTAKE; H MIYOSHI; T SATOH; T HATANO; H IWAMURA

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, May 1994, Peer-reviewed

  
• ANALYSIS OF REVERTANTS FROM RESPIRATORY DEFICIENT MUTANTS WITHIN THE CENTER-N OF CYTOCHROME-B IN SACCHAROMYCES-CEREVISIAE

  JY COPPEE; N TOKUTAKE; D MARC; JP DIRAGO; H MIYOSHI; AM COLSON

  FEBS LETTERS, Feb. 1994, Peer-reviewed

  
• Analyses of the Acid Dissociation Constants of Multisubstituted Diarylamines Measured in Solvents and Micellar System.

  Guo Ze-jian; Miyoshi Hideto; Fujita Toshio

  Bull. Chem. Soc. Jpn., 1994

  
• Quantitative analysis of the antimicrobial activity and membrane-perturbation potency of antifouling para-substituted alkylphenols

  Hideo Etoh; Nobuyoshi Ban; Junko Fujiyoshi; Nobuko Murayama; Kimio Sugiyama; Naoharu Watanabe; Kanzo Sakata; Kazuo Ina; Hideto Miyoshi; Hajime Iwamura

  Bioscience, Biotechnology and Biochemistry, 1994, Peer-reviewed

  
• COMPARISON OF THE STRUCTURES OF THE QUINONE-BINDING SITES IN BEEF-HEART MITOCHONDRIA

  AK TAN; RR RAMSAY; TP SINGER; H MIYOSHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1993, Peer-reviewed

  
• Quantitative analysis of electron transport inhibition of rat-liver mitochondrial cytochrome bc1 complex by nitrophenols

  Hideto Miyoshi; Isao Saitoh; Hajime Iwamura

  BBA - Bioenergetics, 10 Jun. 1993, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS OF ELECTRON-TRANSPORT INHIBITION OF RAT-LIVER MITOCHONDRIAL CYTOCHROME-BC1 COMPLEX BY NITROPHENOLS

  H MIYOSHI; SAITOH, I; H IWAMURA

  BIOCHIMICA ET BIOPHYSICA ACTA, Jun. 1993, Peer-reviewed

  
• Inhibition of electron transport of rat-liver mitochondria by synthesized antimycin A analogs

  Nobuya Tokutake; Hideto Miyoshi; Hitoshi Nakazato; Hajime Iwamura

  BBA - Bioenergetics, 06 May 1993, Peer-reviewed

  
• INHIBITION OF ELECTRON-TRANSPORT OF RAT-LIVER MITOCHONDRIA BY SYNTHESIZED ANTIMYCIN-A ANALOGS

  N TOKUTAKE; H MIYOSHI; H NAKAZATO; H IWAMURA

  BIOCHIMICA ET BIOPHYSICA ACTA, May 1993, Peer-reviewed

  
• ACIDITY AND DYNAMIC STRUCTURE OF THE POTENT UNCOUPLER SF6847 (2,6-DI-T-BUTYL-4-(2,2-DICYANOVINYL)PHENOL) AND ITS DERIVATIVES

  H MIYOSHI; Z GUO; T FUJITA; H IWAMURA

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jan. 1993, Peer-reviewed

  
• UNCOUPLING ACTION OF ANTIBIOTIC SPORAVIRIDINS WITH RAT-LIVER MITOCHONDRIA

  H MIYOSHI; M TAMAKI; K HARADA; H MURATA; M SUZUKI; H IWAMURA

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 1992, Peer-reviewed

  
• COMPARISON OF STRUCTURE OF QUINONE REDOX SITE IN THE MITOCHONDRIAL CYTOCHROME-BC1 COMPLEX AND PHOTOSYSTEM-II (QB SITE)

  SAITOH, I; H MIYOSHI; R SHIMIZU; H IWAMURA

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Oct. 1992, Peer-reviewed

  
• EFFECTS OF PHENOLIC RESPIRATION INHIBITORS ON CYTOCHROME-BC1 COMPLEX OF RAT-LIVER MITOCHONDRIA

  N TOKUTAKE; H MIYOSHI; H IWAMURA

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 1992, Peer-reviewed

  
• INHIBITION OF ELECTRON-TRANSPORT OF RAT-LIVER MITOCHONDRIA BY UNNATURAL (-)-ANTIMYCIN-A3

  H MIYOSHI; H KONDO; T ORITANI; SAITOH, I; H IWAMURA

  FEBS LETTERS, Nov. 1991, Peer-reviewed

  
• Quantitative analysis with physicochemical substituent and molecular parameters of uncoupling activity of substituted diarylamines

  Ze-jian Guo; Hideto Miyoshi; Terumasa Komyoji; Takahiro Haga; Toshio Fujita

  BBA - Bioenergetics, 02 Aug. 1991, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS WITH PHYSICOCHEMICAL SUBSTITUENT AND MOLECULAR-PARAMETERS OF UNCOUPLING ACTIVITY OF SUBSTITUTED DIARYLAMINES

  ZJ GUO; H MIYOSHI; T KOMYOJI; T HAGA; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Aug. 1991, Peer-reviewed

  
• Electron transport inhibition of the cytochrome bc1 complex of rat-liver mitochondria by phenolic uncouplers

  Nobuya Tokutake; Hideto Miyoshi; Toshio Fujita

  BBA - Bioenergetics, 06 May 1991, Peer-reviewed

  
• CORRELATION OF THE ACID DISSOCIATION-CONSTANTS OF SOME MULTISUBSTITUTED DIPHENYLPYRIDYLAMINES AND PHENYLPYRIDYLAMINES

  ZJ GUO; H MIYOSHI; K NAGATANI; T KOMYOJI; T HAGA; T FUJITA

  JOURNAL OF ORGANIC CHEMISTRY, May 1991, Peer-reviewed

  
• ELECTRON-TRANSPORT INHIBITION OF THE CYTOCHROME-BC1 COMPLEX OF RAT-LIVER MITOCHONDRIA BY PHENOLIC UNCOUPLERS

  N TOKUTAKE; H MIYOSHI; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, May 1991, Peer-reviewed

  
• Uncoupling activity of a newly developed fungicide, fluazinam [3-chloro-N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-2-pyridinamine]

  Ze-jian Guo; Hideto Miyoshi; Terumasa Komyoji; Takahiro Haga; Toshio Fujita

  BBA - Bioenergetics, 03 Jan. 1991, Peer-reviewed

  
• UNCOUPLING ACTIVITY OF A NEWLY DEVELOPED FUNGICIDE, FLUAZINAM [3-CHLORO-N-(3-CHLORO-2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)-5-TRIFLUOROMETHYL-2-PYRIDINAMINE]

  ZJ GUO; H MIYOSHI; T KOMYOJI; T HAGA; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Jan. 1991, Peer-reviewed

  
• Quantitative analysis of uncoupling activity of substituted phenols with a physicochemical substituent and molecular parameters

  Hideto Miyoshi; Hideki Tsujishita; Nobuya Tokutake; Toshio Fujita

  BBA - Bioenergetics, 15 Mar. 1990, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS OF UNCOUPLING ACTIVITY OF SUBSTITUTED PHENOLS WITH A PHYSICOCHEMICAL SUBSTITUENT AND MOLECULAR-PARAMETERS

  H MIYOSHI; H TSUJISHITA; N TOKUTAKE; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Mar. 1990, Peer-reviewed

  
• Quantitative analyses of the uncoupling activity of substituted phenols with mitochondria from flight muscles of house flies

  Hideto Miyoshi; Toshio Fujita

  BBA - Bioenergetics, 05 Oct. 1988, Peer-reviewed

  
• QUANTITATIVE-ANALYSES OF THE UNCOUPLING ACTIVITY OF SUBSTITUTED PHENOLS WITH MITOCHONDRIA FROM FLIGHT MUSCLES OF HOUSE-FLIES

  H MIYOSHI; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Oct. 1988, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS OF PARTITION BEHAVIOR OF SUBSTITUTED PHENOLS FROM AQUEOUS PHASE INTO LIPOSOMES MADE OF LECITHIN AND VARIOUS LIPIDS

  H MIYOSHI; H MAEDA; N TOKUTAKE; T FUJITA

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Dec. 1987, Peer-reviewed

  
• Quantitative analyses of uncoupling activity of SF6847 (2,6-di-t-butyl-4-(2,2-dicyanovinyl)phenol) and its analogs with spinach chloroplasts

  Hideto Miyoshi; Toshio Fujita

  BBA - Bioenergetics, 19 Nov. 1987, Peer-reviewed

  
• QUANTITATIVE-ANALYSES OF UNCOUPLING ACTIVITY OF SF6847 (2,6-DI-T-BUTYL-4-(2,2-DICYANOVINYL)PHENOL) AND ITS ANALOGS WITH SPINACH-CHLOROPLASTS

  H MIYOSHI; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Nov. 1987, Peer-reviewed

  
• Quantitative relationship between protonophoric and uncoupling activities of analogs of SF6847 (2,6-di-t-butyl-4-(2′,2′-dicyanovinyl)phenol)

  Hideto Miyoshi; Takaaki Nishioka; Toshio Fujita

  BBA - Bioenergetics, 06 May 1987, Peer-reviewed

  
• QUANTITATIVE RELATIONSHIP BETWEEN PROTONOPHORIC AND UNCOUPLING ACTIVITIES OF ANALOGS OF SF6847 (2,6-DI-TERT-BUTYL-4-(2',2'-DICYANOVINYL)PHENOL)

  H MIYOSHI; T NISHIOKA; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, May 1987, Peer-reviewed

  
• Quantitative relationship between protonophoric and uncoupling activities of substituted phenols

  Hideto Miyoshi; Takaaki Nishioka; Toshio Fujita

  BBA - Bioenergetics, 15 Apr. 1987, Peer-reviewed

  
• QUANTITATIVE RELATIONSHIP BETWEEN PROTONOPHORIC AND UNCOUPLING ACTIVITIES OF SUBSTITUTED PHENOLS

  H MIYOSHI; T NISHIOKA; T FUJITA

  BIOCHIMICA ET BIOPHYSICA ACTA, Apr. 1987, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS OF EFFECTS OF SUBSTITUTED PHENOLS ON MEMBRANE-CHARACTERISTICS OF LECITHIN LIPOSOMES

  H MIYOSHI; T NISHIOKA; T FUJITA

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Apr. 1986, Peer-reviewed

  

Misc.

• ミトコンドリア複合体-Iによる合成ユビキノンQTの還元はプロトン輸送と共役しない

  奥田健司; 村井正俊; 油屋駿介; 青木航; 三芳秀人

  日本農芸化学会大会講演要旨集(Web), 2016

  
• トシル化学によるミトコンドリア複合体-Iのユビキノン結合部位の特異的メチル化

  稲岡宏幸; 村井正俊; 桝谷貴洋; 油屋駿介; 青木航; 三芳秀人

  日本農芸化学会大会講演要旨集(Web), 2016

  
• サイトカイニンおよび類縁体の植物ミトコンドリア複合体I阻害活性 : 有機化学・天然物化学

  須恵 雅之; 三芳 秀人; 岩村 俶

  日本農藝化學會誌, 05 Mar. 1996

  
• 植物ミトコンドリアNADHデヒドロゲナーゼめ新規阻害剤とその特性 : 有機化学・天然物化学

  朱 長進; 須恵 雅之; 三芳 秀人; 岩村 俶

  日本農藝化學會誌, 05 Mar. 1996

  
• 合成ロテノン類縁体を用いたミトコンドリアNADH-ユビキノン酸化還元酵素(複合体I)の機能解明 : 物理化学・分析化学

  植野 英樹; 三芳 秀人; 井上 誠; 岩村 俶

  日本農藝化學會誌, 05 Jul. 1995

  
• 種々のNADH-ユビキノン酸化還元酵素(NDH)に対する合成カプサイシン類の阻害効果 : 物理化学・分析化学

  坂元 君年; 三芳 秀人; 佐藤 卓士; 岩村 俶

  日本農藝化學會誌, 05 Jul. 1995

  
• A110 ロテノンおよびその立体異性体のミトコンドリア複合体 : I 活性の阻害機構

  三芳 秀人; 植野 英樹; 岩村 俶

  講演要旨集, 01 May 1994

  
• 競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位

  山下哲生; 稲岡健ダニエル; 志波智生; 三芳秀人; 原田繁春; 北潔; 平野勝也

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2018

  
• 新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定

  山下哲生; 稲岡健ダニエル; 稲岡健ダニエル; 志波智生; 大橋拓未; 岩田想; 岩田想; 岩田想; 岩田想; 矢木隆雄; 小坂博昭; 三芳秀人; 原田繁春; 北潔; 北潔; 平野勝也

  日本生化学会大会(Web), 2018

  
• A125 呼吸阻害剤 Antimycin A の構造活性相関

  徳竹 伸哉; 佐藤 卓士; 三芳 秀人; 岩村 俶

  講演要旨集, 01 Mar. 1993

  
• A124 塩基性配糖体抗生物質 Aculeximycin の脱共役機構(第 2 報)

  三芳 秀人; 玉木 元人; 岩村 俶; 池本 孝哉; 渋谷 敏朗; 原田 健一; 村田 英明; 鈴木 真言

  講演要旨集, 01 Mar. 1993

  
• 82. Effects of tryptophan decarboxylase inhibition on defense responses of rice

  Nakao Takahito; Ishihara Atsushi; Tanaka Chihiro; Miyoshi Hideto; Wakasa Kyo; Miyagawa Hisashi

  植物化学調節学会研究発表記録集, 06 Oct. 2009

  
• 光反応性ホスファチジルコリンを用いた脂質抱合型apoA-Iの標識手法の確立

  藤本和希; 木村泰久; 安部真人; 三芳秀人; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2018

  
• 合成リゾカルジオリピン類縁体のトランスアシラーゼtafazzinに対する阻害効果

  安部真人; 千ヶ崎修平; 奥公秀; 阪井康能; 三芳秀人

  脂質生化学研究, 2019

  
• ミトコンドリア膜リン脂質カルジオリピンのリモデリング機構

  安部真人; 澤田良樹; 奥公秀; 阪井康能; 三芳秀人

  脂質生化学研究, 15 May 2018

  
• 酵母tafazzinによるカルジオリピンのリモデリング反応の基質特異性

  安部真人; 澤田良樹; 宇野晋平; 千ヶ崎修平; 奥公秀; 阪井康能; 三芳秀人

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2018

  
• リン脂質ホスファチジルコリンの脱メチル化類縁体の合成研究

  安部真人; 辻諄人; 三芳秀人

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2018

  
• ミトコンドリア膜表在性リモデリング酵素タファジンにおけるエーテル型PCの基質認識

  安部真人; 千ヶ崎修平; 奥公秀; 阪井能義; 三芳秀人

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2018

  
• 薬剤感受性出芽酵母を用いたミトコンドリアを標的とする新規農薬リード化合物decatamariic acidの取得

  渡邊善洋; 須賀拓弥; 成沢里美; 横川怜美; 岩月正人; 岩月正人; 野中健一; 野中健一; 中島琢自; 中島琢自; 篠原康雄; 塩月孝博; 一丸直哉; 三芳秀人; 浅見行弘; 浅見行弘; 大村智; 塩見和朗; 塩見和朗

  日本農芸化学会大会講演要旨集(Web), 2017

  
• カルジオリピン含有リポソームを用いた酵母由来tafazzinの基質特異性の解明

  安部真人; 長谷川結以; 奥公秀; 澤田良樹; 田中絵里子; 阪井康能; 三芳秀人

  生体膜と薬物の相互作用シンポジウム講演要旨集, 17 Nov. 2016

  
• Saccharomyces cerevisiae由来tafazzinによるカルジオリピンのトランスアシル化反応の基質特異性

  安部真人; 長谷川結以; 奥公秀; 澤田良樹; 田中絵里子; 阪井康能; 三芳秀人

  日本生化学会大会(Web), Sep. 2016

  
• 出芽酵母tafazzinによるカルジオリピンのリモデリング機構に関する研究

  長谷川裕以; 安部真人; 奥公秀; 阪井康能; 三芳秀人

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2016

  
• ミトコンドリア複合体‐I阻害剤としてのアミロライド類の作用機構研究

  MURAI MASATOSHI; MURAKAMI SONOMI; ITO TAKESHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 18 Mar. 2015

  
• ミトコンドリア複合体‐Iのピンポイント化学修飾

  MASUYA TAKAHIRO; MURAI MASATOSHI; MORISAKA HIRONOBU; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 18 Mar. 2015

  
• ウリ類炭疽病菌におけるMORシグナル伝達経路は胞子表面エステラーゼにより生成されたクチンモノマー認識を介した付着器形成に関与する

  KODAMA SAYO; SAKAGUCHI AYUMU; ISHIZUKA JUN'YA; ISHIZUKA JUN'YA; MIYASHITA ISSHI; NISHIUCHI TAKUMI; ISHII TAKAAKI; MIYOSHI HIDETO; KUBO YASUYUKI

  日本植物病理学会大会プログラム・講演要旨予稿集, 10 Mar. 2015

  
• 昆虫のミトコンドリア膜ADP/ATP輸送体の遺伝子と機能の特性

  SUGAHARA RYOHEI; JORAKU AKIYA; SHINOHARA YASUO; MIYOSHI HIDETO; SHIOTSUKI TAKAHIRO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• ミトコンドリア複合体‐Iにおけるアセトゲニンの結合部位の同定

  HIRANO KEITARO; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• 出芽酵母ミトコンドリアVDACにおけるユビキノン結合部位の同定

  OKUDA AYAKA; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• アミロライド類縁体のミトコンドリア複合体‐Iにおける結合部位の同定

  ITO TAKESHI; MURAI MASATOSHI; MORISAKA HIRONOBU; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• 新規eptaibol化合物であるFKI‐6324Aは害虫AAC遺伝子組換え酵母の増殖を抑制する

  SUGA TAKUYA; ASAMI YUKIHIRO; HASHIMOTO SHOHEI; IWATSUKI MASATO; NONAKA KEN'ICHI; NAKASHIMA TAKUJI; WATANABE YOSHIHIRO; MATSUMOTO ATSUKO; SUGAWARA RYOHEI; SHIOTSUKI TAKAHIRO; YAMAMOTO TAKENORI; SHINOHARA YASUO; ICHIMARU NAOYA; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• ミトコンドリア複合体‐Iのピンポイント化学修飾

  MASUYA TAKAHIRO; MURAI MASATOSHI; MORISAKA HIRONOBU; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• リン脂質カルジオリピンのシトクロムcに対する結合部位の同定

  ABE MASATO; TANABE YUKIE; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• コレラ菌ナトリウム輸送型NADH‐ユビキノン酸化還元酵素(Na⁺‐NQR)におけるユビキノン結合部位の同定

  NINOKURA SATOSHI; MURAI MASATOSHI; BARQUERA BLANCA; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• 昆虫ミトコンドリアのADP/ATP carrierの酵母における機能的発現

  HARADA KAZUKI; INOTANI YUKI; SUGAWARA RYOHEI; SHIOTSUKI TAKAHIRO; MIYOSHI HIDETO; HASHIMOTO MITSURU; MAJIMA EIJI; TERADA HIROSHI; YAMAMOTO TAKENORI; SHINOHARA YASUO

  日本薬学会年会要旨集(CD-ROM), 2015

  
• ミトコンドリア複合体‐Iのピンポイント化学修飾

  MASUYA TAKAHIRO; MURAI MASATOSHI; MORISAKA HIRONOBU; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 11 Dec. 2014

  
• ミトコンドリア複合体‐Iのメカニズム解明に向けた特異的化学修飾

  MIYOSHI HIDETO; MASUTANI TAKAHIRO; MURAI MASATOSHI

  生体膜と薬物の相互作用シンポジウム講演要旨集, 20 Nov. 2014

  
• コエンザイムQ結合タンパク質Coq10の解析

  KAWAMUKAI MAKOTO; SAI TOSHITADA; KAINO TOMOHIRO; MURAI MASATOSHI; MIYOSHI HIDETO

  イソプレノイド研究会例会講演要旨集, 12 Sep. 2014

  
• カルジオリピン‐シトクロムc複合体のペルオキシダーゼ誘導の分子機構

  MIKI YUKO; ABE MASATO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 13 Mar. 2014

  
• ミトコンドリア複合体‐Iの位置特異的化学修飾

  MASUYA TAKAHIRO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 13 Mar. 2014

  
• ミトコンドリア複合体‐I阻害剤としてのアミロライド類縁体の合成と作用機構の解明

  MURAKAMI SONOMI; ITO TAKESHI; HABU SAYAKO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 13 Mar. 2014

  
• ミトコンドリアADP/ATP輸送体を生物種選択的に阻害する化合物の探索

  MIYOSHI HIDETO; SHIOTSUKI TAKAHIRO; SHINOHARA YASUO; SHIOMI KAZURO

  日本農薬学会大会講演要旨集, 13 Mar. 2014

  
• リン脂質カルジオリピンのシトクロムcへの結合部位の同定

  KOSAKA AYUMI; TANABE YUKIE; ABE MASATO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 13 Mar. 2014

  
• カイコにおけるATP/ADP輸送蛋白質(Ant)遺伝子のクローニングと機能解析

  SUGAHARA RYOHEI; JORAKU AKIYA; SHINOHARA YASUO; MIYOSHI HIDETO; SHIOTSUKI TAKAHIRO

  日本蚕糸学会大会・蚕糸・昆虫機能学術講演会講演要旨集, 09 Mar. 2014

  
• ミトコンドリアNADH‐ユビキノン酸化還元酵素(複合体‐I)の部位特異的化学修飾

  MASUYA TAKAHIRO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• シトクロムc‐カルジオリピン複合体のペルオキシダーゼ活性誘導の分子機構

  MIKI YUKO; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• キナゾリンのミトコンドリアADP/ATP輸送体における結合部位の同定

  ASANO SHU; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• ユビキノン結合性タンパク質Coq10におけるキノン結合部位の同定

  MATSUNOBU KOHEI; MURAI MASATOSHI; KAWAMUKAI MAKOTO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• 病害虫ミトコンドリアに作用する天然物リガンドの探索

  ASAMI YUKIHIRO; MORI MIHOKO; SUGA TAKUYA; IWATSUKI MASATO; NAKASHIMA TAKUJI; HASHIMOTO SHOHEI; NONAKA KEN'ICHI; MATSUMOTO ATSUKO; YUGE HIDETAKA; MASUMA ROKURO; TAKAHASHI YOKO; SUGAHARA RYOHEI; SHIOTSUKI TAKAHIRO; YAMAMOTO TAKENORI; SHINOHARA YASUO; ICHIMARU NAOYA; MURAI MASATOSHI; MIYOSHI HIDETO; OMURA SATOSHI; SHIOMI KAZURO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• リン脂質カルジオリピンのシトクロムcに対する結合部位の同定

  KOSAKA AYUMI; TANABE YUKIE; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• C35位を改変したバンレイシ科アセトゲニン誘導体のヒトがん細胞増殖抑制活性

  HIRATA SHOYA; KOJIMA NAOTO; SATOMI JUN'ICHIRO; KANO MASAFUMI; OTSUKI KAZUFUMI; TANAKA TETSUAKI; YAMORI TAKAO; ABE MASATO; MIYOSHI HIDETO; IWASAKI HIROKI; YAMASHITA MASAYUKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 合成ユビキノンプローブを用いたミトコンドリアタンパク質Coq10の解析

  MURAI MASATOSHI; MATSUNOBU KOHEI; KAWAMUKAI MAKOTO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 18 Dec. 2013

  
• ユビキノンプローブの合成とユビキノン結合性タンパク質Coq10の解析

  MURAI MASATOSHI; MATSUNOBU KOHEI; KUDO SAWAKO; KAWAMUKAI MAKOTO; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 05 Sep. 2013

  
• キナゾリン型阻害剤を用いたミトコンドリアNADH‐ユビキノン酸化還元酵素(複合体‐I)のドメイン間相互作用の解明

  MURAI MASATOSHI; MASHIMO YUKO; HIRST JUDY; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 14 Mar. 2013

  
• ユビキノンプローブの合成とユビキノン結合性タンパク質Coq10の解析

  MATSUNOBU KOHEI; MURAI MASATOSHI; KUDO SAWAKO; KAWAMUKAI MAKOTO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• ミトコンドリア複合体‐Iに作用する光反応性フェンピロキシメートの結合部位の同定

  MURAI MASATOSHI; SHIRAISHI YUSUKE; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• ミトコンドリア複合体‐I阻害剤としてのアミロライド類縁体の合成と作用機構

  HABU SAYAKO; MURAKAMI SONOMI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• ミトコンドリア複合体‐Iに作用するキナゾリン型阻害剤の結合部位の同定

  ASANO SHU; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• カルジオリピン‐シトクロムc複合体形成の分子機構解明

  ABE MASATO; NAKANO MASAAKI; KOSAKA AYUMI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• C35‐フッ素化solaminの合成とミトコンドリア複合体I阻害活性

  KANO MASABUMI; KOJIMA NAOTO; SUGA TOMOKI; OTSUKI KAZUFUMI; TANAKA TETSUAKI; ABE MASATO; MIYOSHI HIDETO; IWASAKI HIROKI; YAMASHITA MASAYUKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 酵母ミトコンドリアにおける昆虫のADP/ATP carrierの機能的発現

  HARADA KAZUKI; INOTANI YUKI; SUGAWARA RYOHEI; SHIOTSUKI TAKAHIRO; MIYOSHI HIDETO; HASHIMOTO MITSURU; TERADA HIROSHI; YAMAMOTO TAKENORI; SHINOHARA YASUO

  日本生化学会大会(Web), 2013

  
• Characterization of the inhibitor-binding site in mitochondrial NADH-Ubiquinone oxidoreductase (complex I) using fenpyroximate analogues

  M. Murai; Y. Shiraishi; N. Sakiyama; H. Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Oct. 2012

  
• ミトコンドリア複合体‐Iの阻害剤結合部位の同定(2):結合部位の概観

  MURAI MASATOSHI; SHIRAISHI YUSUKE; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 14 Mar. 2012

  
• ミトコンドリア複合体‐Iの阻害剤結合部位の同定(1):フェンピロキシメートの結合部位

  SHIRAISHI YUSUKE; MURAI MASATOSHI; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 14 Mar. 2012

  
• 光反応性アセトゲニンの合成と作用機構研究

  ABE MASATO; NAKANISHI SAYO; YAMAMOTO SHUHEI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 14 Mar. 2012

  
• ミトコンドリア複合体‐Iにおけるアセトゲニン結合部位の同定

  NAKANISHI SAYO; ABE MASATO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• シトクロムc‐カルジオリピン複合体のペルオキシダーゼ活性発現の分子機構

  NIIBAYASHI RYOTA; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• ユビキノンプローブの創製と出芽酵母におけるユビキノン結合性タンパク質のスクリーニング

  KUDO SAWAKO; MURAI MASATOSHI; YAZAKI KAZUFUMI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• ミトコンドリア複合体‐Iの阻害剤結合部位の同定

  MURAI MASATOSHI; SHIRAISHI YUSUKE; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2012

  
• シトクロムc‐カルジオリピン複合体形成によるペルオキシダーゼ活性誘導の分子機構

  ABE MASATO; NAKANO MASAAKI; MIYOSHI HIDETO

  日本生化学会大会(Web), 2012

  
• ミトコンドリア電子伝達酵素複合体‐Iに作用する阻害剤の作用機構

  MIYOSHI HIDETO

  構造活性相関シンポジウム講演要旨集, 17 Nov. 2011

  
• 機能性ユビキノンプローブの合成と結合タンパク質の同定

  DOI SAYAKO; MURAI MASATOSHI; YOKOYAMA MINORU; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 01 Oct. 2011

  
• 新規な光合成サイクリック電子伝達阻害剤の探索

  TAIRA SUMITAKA; OKEKAWA TOMOKI; SUGIMOTO KAZUHIKO; ABE MASATO; MIYOSHI HIDETO; SHIKAUCHI TOSHIHARU

  日本植物生理学会年会要旨集, 11 Mar. 2011

  
• カルジオリピン類の合成によるシトクロムcとの分子間相互作用の解析

  SHIMBAYASHI RYOTA; KOBORI SHIN'YA; MORIYAMA IKUKO; ABE MASATO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• ミトコンドリア複合体‐Iにおけるアセトゲニンの結合部位の同定

  NAKANISHI SAYO; ABE MASATO; YAMAMOTO SHUHEI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• 光親和性ユビキノンプローブの合成と標的タンパク質の解析

  HABU SAYAKO; YOKOYAMA MINORU; MURAI MASATOSHI; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• ミトコンドリア複合体‐Iに作用する光反応性フェンピロキシメートの結合部位の同定

  MURAI MASATOSHI; SAKIYAMA NAOTO; SHIRAISHI YUSUKE; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• ミトコンドリア複合体‐Iに作用する光反応性フェンピロキシメートの結合部位の同定(I)

  MURAI MASATOSHI; SAKIYAMA NAOTO; SHIRAISHI YUSUKE; ABE MASATO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 25 Feb. 2011

  
• ミトコンドリア複合体‐Iに作用する光反応性フェンピロキシメートの結合部位の同定(II)

  SAKIYAMA NAOTO; MURAI MASATOSHI; SHIRAISHI YUSUKE; ABE MASATO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 25 Feb. 2011

  
• 光反応性アセトゲニンの合成と作用機構研究

  ABE MASATO; NAKANISHI SAYO; YAMAMOTO SHUHEI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 25 Feb. 2011

  
• 機能性ユビキノンプローブの合成とユビキノン結合性タンパク質の探索

  YOKOYAMA MINORU; HABU SAYAKO; MURAI MASATOSHI; ABE MASATO; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 2011

  
• キナゾリン型阻害剤を用いたミトコンドリアNADH‐ユビキノン酸化還元酵素(複合体‐I)のドメイン間相互作用の解明

  MURAI MASATOSHI; MASHIMO YUKO; HIRST JUDY; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2011

  
• ミトコンドリア複合体‐Iに作用する光反応性フェンピロキシメートの結合部位の同定

  SHIRAISHI YUSUKE; MURAI MASATOSHI; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2011

  
• Molecular Mechanism for Induction of Peroxidase Activity of Cytochrome c-Cardiolipin Complex

  ABE MASATO; NIIBAYASHI RYOTA; KOBORI SHIN'YA; MORIYAMA IKUKO; MIYOSHI HIDETO

  生化学, 2011

  
• 酵母Type II NADH脱水素酵素(NDH‐2)において活性酸素の生成が負に制御される分子機構の解析

  YAMASHITA TETSUO; YANG YU; OGISO(NAKAMARU) EIKO; HASHIMOTO TAKESHI; MURAI MASATOSHI; MIYOSHI HIDETO; IGARASHI JUNSUKE; YAGI(MATSUNO) AKEMI; YAGI TAKAO; KOSAKA HIROAKI

  日本生体エネルギー研究会討論会講演要旨集, 2011

  
• 酵母シングルサブユニット・NADH‐キノン酸化還元酵素(Ndi1)の反応機構:活性酸素の生成抑制機構の解析

  YAMASHITA TETSUO; YANG YU; NAKAMARU EIKO; HASHIMOTO TAKESHI; MURAI MASATOSHI; IGARASHI JUNSUKE; MIYOSHI HIDETO; YAGI AKEMI; YAGI TAKAO; KOSAKA HIROAKI

  生化学, 2011

  
• シトクロムc‐カルジオリピン複合体のペルオキシダーゼ活性発現の分子機構

  NIIBAYASHI RYOTA; ABE MASATO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2011

  
• 呼吸鎖酵素最後の秘境 複合体‐I(NADH‐ユビキノン酸化還元酵素)の構造と機能

  MURAI MASATOSHI; MIYOSHI HIDETO

  化学, 01 Jan. 2011

  
• 光反応性アセトゲニンの合成と作用機構研究

  NAKANISHI SAYO; YAMAMOTO SHUHEI; ABE MASATO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 02 Oct. 2010

  
• モノテトラヒドロフラン型バンレイシ科アセトゲニンの系統的な合成とテトラヒドロピラン環を有するアセトゲニンの合成研究

  MAKABE HIDEFUMI; HATTORI YASUNAO; OASA MAYU; SHIMAMOTO YASUHIRO; KONNO HIROYUKI; ABE MASATO; MIYOSHI HIDETO

  天然有機化合物討論会講演要旨集, 01 Sep. 2010

  
• Synthesis of cardiolipin analogues bearing a biophysical probe at any position of the four acyl chains

  Masato Abe; Shunya Koubori; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 2010

  
• Characterization of the binding site of Delta lac-acetogenin in bovine mitochondrial complex I by photoaffinity labeling

  Masatoshi Murai; Nobuyuki Kakutani; Naoto Sakiyama; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 2010

  
• ミトコンドリア複合体‐I阻害剤Δlac‐アセトゲニンの結合部位の同定

  MURAI MASATOSHI; KAKUTANI NOBUYUKI; SAKIYAMA NAOTO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 21 Apr. 2010

  
• 光反応性アセトゲニンの合成と作用機構研究

  ABE MASATO; YAMAMOTO SHUHEI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 21 Apr. 2010

  
• シロイヌナズナの病原菌感染応答におけるヒドロキシ桂皮酸アミド生合成に関する研究

  MUROI ATSUSHI; ISHIHARA ATSUSHI; TANAKA CHIHIRO; ISHIZUKA AKIHIRO; TAKABAYASHI JUNJI; MIYOSHI HIDETO; NISHIOKA TAKAAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• 広汎なカルジオリピン類の有機合成と生理活性評価

  ABE MASATO; OYAMA SHUNJI; KOBORI SHIN'YA; MORIYAMA IKUKO; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• ミトコンドリア複合体‐I阻害剤Δlac‐アセトゲニンの結合部位の同定

  MURAI MASATOSHI; SUMIYA SHINJI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• ミトコンドリア複合体‐I阻害剤Δlac‐アセトゲニンの結合部位の同定

  SUMIYA SHINJI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 2010

  
• 酵母の非プロトン輸送性NADH‐ユビキノン酸化還元酵素(Ndi1)のユビキノン結合部位の解明

  MASHIMO YUKO; MURAI MASATOSHI; YAMASHITA TETSUO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2010

  
• カルジオリピンの合成に基づくシトクロムc‐カルジオリピン複合体形成の分子機構解明

  ABE MASATO; NIIBAYASHI RYOTA; KOBORI SHIN'YA; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2010

  
• ミトコンドリア複合体‐I阻害剤Δlac‐アセトゲニンの結合部位の解明

  MURAI MASATOSHI; KAKUTANI NOBUYUKI; SAKIYAMA NAOTO; ABE MASATO; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2010

  
• トリプトファンデカルボキシラーゼ阻害がイネの抵抗反応に及ぼす影響

  NAKAO TAKAHITO; ISHIHARA ATSUSHI; TANAKA CHIHIRO; MIYOSHI HIDETO; WAKASA KYO; MIYAGAWA HISASHI

  植物の生長調節, 06 Oct. 2009

  
• トリプトファンデカルボキシラーゼ阻害剤の開発とイネの抵抗反応に及ぼす効果

  NAKAO TAKAHITO; ISHIHARA TOORU; MIYAGAWA HISASHI; MIYOSHI HIDETO; WAKASA AKIRA

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• ミトコンドリア複合体‐Iに作用する光反応性アセトゲニンの合成と結合部位の解析

  MURAI MASATOSHI; SEKIGUCHI KOJI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• 光親和性標識法によるミトコンドリア複合体‐I阻害剤キナゾリンの結合部位の解析

  SEKIGUCHI KOJI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• トリプトファンデカルボキシラーゼ阻害剤がイネの感染応答に及ぼす影響

  ISHIHARA ATSUSHI; NAKAO TAKAHITO; TANAKA CHIHIRO; MIYAGAWA HISASHI; MIYOSHI HIDETO; WAKASA KYO

  日本農薬学会大会講演要旨集, 27 Feb. 2009

  
• 光親和性標識法によるミトコンドリア複合体‐I阻害剤キナゾリンの結合部位の解析

  SEKIGUCHI KOJI; MURAI MASATOSHI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 27 Feb. 2009

  
• ミトコンドリア複合体‐Iに作用するアセトゲニンの結合部位の解析

  MURAI MASATOSHI; SEKIGUCHI KOJI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 27 Feb. 2009

  
• パラジウム触媒による環化反応を用いたpyranicinとspectamine Aの合成研究

  MORI YOSHIHIRO; HATTORI YASUNAO; FURUHATA SHIN'ICHI; KONNO HIROYUKI; ABE MASATO; MIYOSHI HIDETO; MAKABE HIDEFUMI

  天然有機化合物討論会講演要旨集, 01 Sep. 2008

  
• Identification of the inhibitor binding SITE(S) in bovine complex-i by photoaffinity labeling

  Masatoshi Murai; Naoya Ichimaru; Takao Yagi; Hideto Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 2008

  
• ミトコンドリア複合体‐I阻害剤の結合部位解明―光親和性標識実験によるアプローチ―

  MURAI MASATOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 11 Mar. 2008

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類の作用機構研究 bis‐THF体とmono‐THF体の比較から

  ABE MASATO; YAMAMOTO SHUHEI; MAKABE HIDEFUMI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 11 Mar. 2008

  
• ミトコンドリア複合体‐Iの新規阻害剤Δlac‐アセトゲニンの合成と作用機構研究

  ICHIMARU NAOYA; MURAI MASATOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 11 Mar. 2008

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類のスペーサー部の機能

  ABE MASATO; YAMAMOTO SHUHEI; NISHIOKA TAKAAKI; MAKABE HIDEFUMI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2008

  
• 光親和性標識法を用いたミトコンドリア複合体‐I阻害剤の結合部位の解析

  MURAI MASATOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2008

  
• Pyranicinの合成とミトコンドリアcomplex Iの阻害活性

  FURUHATA SHIN'ICHI; HATTORI YASUNAO; KONNO HIROYUKI; ABE MASATO; MIYOSHI HIDETO; GOTO TETSUHISA; MAKABE HIDEFUMI

  日本農芸化学会大会講演要旨集, 05 Mar. 2008

  
• 新規Δlac‐アセトゲニンの合成と構造活性相関研究

  ICHIMARU NAOYA; KAKO JUNKO; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• 光親和性標識法によるΔlac‐アセトゲニンの結合部位同定

  MURAI MASATOSHI; ICHIMARU NAOYA; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• ミトコンドリア複合体―I阻害剤アセトゲニン類のスペーサー部の機能

  ABE MASATO; HATO YOSHIMICHI; MAKABE HIDEFUMI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• 新規抗多包条虫薬の標的としての嫌気的ミトコンドリア呼吸鎖

  MATSUMOTO JEN; SAKAMOTO KIMITOSHI; SHINJO NORIKO; KIDO YASUTOSHI; YAMAMOTO NAO; KITA KIYOSHI; MIYOSHI HIDETO; YAGI KIMPEI; NONAKA NARIAKI; KATAKURA KEN; OKU YUSABURO

  日本寄生虫学会大会プログラム・抄録集, 23 Feb. 2007

  
• Synthesis of (17S, 18S)- and (17R, 18R)-tonkinelin and their inhibitory action with bovine heart mitochondorial complex I.

  Hattori, Y; Konno, H; Abe, M; Miyoshi, H; Goto, T; Makabe, H

  Bioorg. Med. Chem., 2007

  
• 抗寄生虫薬の標的となる嫌気的呼吸鎖電子伝達系

  SAKAMOTO KIMITOSHI; MATSUMOTO JUN; YAGI KIMPEI; KATAKURA KEN; MIYOSHI HIDETO; HARADA SHIGEHARU; KITA KIYOSHI

  日本生体エネルギー研究会討論会講演要旨集, 2007

  
• 呼吸酵素を標的とする新規抗菌剤の開発に向けた天然抗生物質のスクリーニング

  MOGI TATSUSHI; UI HIDEAKI; SHIOMI KAZUO; OMURA SATOSHI; MIYOSHI HIDETO; KITA KIYOSHI

  日本生体エネルギー研究会討論会講演要旨集, 2007

  
• 酵母シングルサブユニット・NADH‐キノン酸化還元酵素(Ndi1)のキノン還元部位の解析

  YAMASHITA TETSUO; YANG YU; OGISO(NAKAMARU) EIKO; MIYOSHI HIDETO; MATSUNO(YAGI) AKEMI; YAGI TAKAO; KOSAKA HIROAKI

  生化学, 2007

  
• ミトコンドリア複合体‐Iの新規阻害剤Δlac‐アセトゲニンの作用機構

  ICHIMARU NAOYA; MURAI MASATOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2007

  
• ミトコンドリア複合体‐Iにおける阻害剤結合部位の解明

  MURAI MASATOSHI; ICHIMARU NAOYA; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本生体エネルギー研究会討論会講演要旨集, 2007

  
• 酵母シングルサブユニット・NADH‐キノン酸化還元酵素(Ndi1)のキノン還元部位の解析

  YAMASHITA TETSUO; YANG Y; OGISO(NAKAMARU) EIKO; MIYOSHI HIDETO; YAGI(MATSUNO) AKEMI; YAGI TAKAO; KOSAKA HIROAKI

  日本生体エネルギー研究会討論会講演要旨集, 2007

  
• 新規アセトゲニンmimics(Δlac‐アセトゲニン)の合成と作用機構研究

  ICHIMARU NAOYA; SENOO MAI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 10 Mar. 2006

  
• ミトコンドリア複合体‐I阻害剤アセトゲニンの阻害機構研究:スペーサー部の機能

  ABE MASATO; KUBO AKINA; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 10 Mar. 2006

  
• Δ‐lacアセトゲニンの複合体‐Iに対する作用機構研究

  MURAI MASATOSHI; ICHIMARU NAOYA; ABE MASAHITO; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• 新規アセトゲニンmimics(Δlac‐アセトゲニン)の合成と作用機構研究

  ICHIMARU NAOYA; MURAI MASATOSHI; ABE MASAHITO; SENO MAI; MAKABE HIDEFUMI; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類の阻害機構研究:スペーサー部の機能

  ABE MASAHITO; MURAI MASATOSHI; ICHIMARU NAOYA; YOSHIDA TAKEHIKO; KUBO AKINA; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• Probing the ubiquinol-binding site in cytochrome bd by site-directed mutagenesis

  T. Mogi; S. Akimoto; S. Endo; T. Watanabe-Nakayama; H. Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2006

  
• ミトコンドリア複合体‐Iの新規阻害剤Δlac‐アセトゲニンの開発

  MURAI MASATOSHI; ICHIMARU NAOYA; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 2006

  
• バンレイシ科アセトゲニンrollicosin,murisolinの合成研究

  HATTORI YASUNAO; KIMURA YUKA; MORODA AKI; HIGUCHI MASAHARU; KONNO HIROYUKI; MURAI MASATOSHI; MIYOSHI HIDETO; MAKABE HIDEFUMI

  天然有機化合物討論会講演要旨集, 15 Sep. 2005

  
• ミトコンドリア呼吸鎖酵素の阻害剤に関する研究

  MIYOSHI HIDETO

  J Pestic Sci, 20 May 2005

  
• Synthesis of delta-lac non-adjacent bis-THF acetogenins and inhibition of mitochondrial complex I

  KONNO HIROYUKI; NOSAKA KAZUTO; AKAJI KEN'ICHI; MAKABE HIDEFUMI; MIYOSHI HIDETO

  日本化学会講演予稿集, 11 Mar. 2005

  
• ミトコンドリア呼吸鎖酵素の阻害剤に関する研究

  MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 10 Mar. 2005

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類のTHF環部の構造修飾

  FUJITA DAISUKE; ICHIMARU NAOYA; ABE MASATO; HAMADA TSUYOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• Δlac‐アセトゲニン類の合成と作用機構研究

  ICHIMARU NAOYA; MURAI MASATOSHI; ABE MASATO; HAMADA TSUYOSHI; MAKINO SAE; MAKABE HIDEFUMI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類の必須構造因子:スペーサー部の機能

  ABE MASATO; HAMADA TSUYOSHI; ICHIMARU NAOYA; YOSHIDA TAKEHIKO; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• 非直結型Bis‐THFアセトゲニンBullatanocinアナログの合成とミトコンドリアComplexの阻害活性評価

  IMANO HIROYUKI; NOSAKA KAZUHITO; AKAJI KEN'ICHI; FUJII NOBUTAKA; MIYOSHI HIDEHITO; MAKABE HIDEFUMI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• ミトコンドリア複合体‐I阻害剤アセトゲニンの阻害機構研究:スペーサー部の機能

  ABE MASATO; MURAI MASATOSHI; ICHIMARU NAOYA; YOSHIDA TAKEHIKO; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会関西支部講演会講演要旨集, 2005

  
• 新規アセトゲニンmimics(Δlac‐アセトゲニン)の合成と作用機構研究

  ICHIMARU NAOYA; MURAI MASATOSHI; ABE MASATO; HAMADA TAKESHI; MAKINO SAE; MAKABE HIDEFUMI; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会関西支部講演会講演要旨集, 2005

  
• モノテトラヒドロフラン型アセトゲニンアナログの合成とミトコンドリア活性

  KONNO HIROYUKI; FUJII NOBUTAKA; MAKABE HIDEFUMI; KIMURA YUKA; MIYOSHI HIDETO; ABE MASATO

  反応と合成の進歩シンポジウム講演要旨集, 24 Sep. 2004

  
• DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation (vol 279, pg 6761, 2004)

  K Inaba; YH Takahashi; N Fujieda; K Kano; H Miyoshi; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2004

  
• ミトコンドリア複合体‐I 阻害剤アセトゲニン類の必須構造因子:THF環部の機能

  ABE MASATO; KENMOCHI ATSUSHI; ICHIMARU NAOYA; HAMADA TSUYOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2004

  
• ラクトン環を持たない新規アセトゲニン類の合成と作用機構研究

  ICHIMARU NAOYA; HAMADA TSUYOSHI; ABE MASATO; NISHIOKA TAKAAKI; BRANDT U; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2004

  
• Synthesis and inhibitory action of novel acetogenin mimics with bovine mitochondrial complex I

  H Miyoshi; T Hamada; N Ichimaru; M Abe; D Fujita; A Kenmochi; T Nishioka; K Zwicker; U Brandt

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2004

  
• Properties of NAD(P)H dehydrogenases isolated from bell pepper chromoplasts

  T Mogi; E Mizuochi; M Yamada; M Yoshida; D Fujita; H Miyoshi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2004

  
• Synthesis and Mitochondrial Complex I Inhibitoin of Mono- and Non-THF Acetogneins.

  Hiroyuki Konno; Naoki Hiura; Yasuhiro Okuno; Hidefumi Makabe; Yasunao Hattori; Hideto Miyoshi; Masato Abe; Nobutaka Fujii

  Proceeding of the 6th Japan/Australia Symposium on Drug Design and Development, 2004

  
• 大腸菌呼吸鎖酵素シトクロムbo₃の阻害剤オーラシンCの構造展開

  SATO KIICHI; MOGI TATSUYUKI; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会関西支部講演会講演要旨集, 04 Oct. 2003

  
• 蛍光阻害剤キナゾリンを用いたミトコンドリア複合体‐Iにおける阻害剤結合部位の解明

  KENMOCHI ATSUSHI; I TAKASHI; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会関西支部講演会講演要旨集, 04 Oct. 2003

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類の必須構造因子:THF環部の機能

  ABE MASATO; KENMOCHI ATSUSHI; ICHIMARU NAOYA; HAMADA TAKESHI; NISHIOKA TAKAAKI; MIYOSHI HIDEHITO

  日本農芸化学会関西支部講演会講演要旨集, 04 Oct. 2003

  
• ブタ回虫Ascaris suumの成虫型ミトコンドリア複合体Iのロドキノン還元部位の解析

  YAMASHITA TETSUO; MIYADERA HIROKO; OSANAI ARIHIRO; SHINJO NORIKO; INO TAKAYOSHI; MIYOSHI HIDETO; KITA KIYOSHI

  日本寄生虫学会大会プログラム・抄録集, 28 Mar. 2003

  
• ¹³C標識stigmatellinの合成とFTIR分光法によるミトコンドリア複合体‐IIIの動態研究

  MIYOSHI HIDETO; ABE MASATO; HELLWING P

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• ミトコンドリア複合体‐I阻害剤アセトゲニン類の必須構造因子の同定

  ABE MASATO; KENMOCHI ATSUSHI; YABUNAKA HIROMI; HAMADA TSUYOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• ハイブリッド・ユビキノン類のミトコンドリア呼吸鎖酵素系における挙動

  KENMOCHI ATSUSHI; YABUNAKA HIROMI; NAKATOGAWA YASUSHI; SAKAMOTO KIMITOSHI; NISHIOKA TAKAAKI; MIYOSHI HIDETO

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• 高等植物色素体由来のNAD(P)H脱水素酵素の酵素化学的性質

  YAMADA MITSUNORI; MIZUOCHI ERI; MIYOSHI HIDEHITO; YOSHIDA MASASUKE; MOGI TATSUYUKI

  日本生物物理学会年会講演予稿集, Nov. 2002

  
• ブタ回虫Ascaris suumの成虫型NAHD‐キノン還元酵素(複合体I)の阻害剤を用いたキノン還元部位の解析

  YAMASHITA TETSUO; MIYADERA HIROKO; I TAKAYOSHI; MIYOSHI HIDEHITO; KITA KIYOSHI

  生化学, 25 Aug. 2002

  
• 酢酸菌のキノヘモプロテイン・アルコール脱水素酵素における結合型ユビキノンとユビキノン反応部位

  MIZUGUCHI MITSUHIRO; KOBAYASHI YOSHINORI; MIGITA TAIKO; SOTOYAMA HIROHIDE; ADACHI KAZUKI; MATSUSHITA KAZUNOBU; SAKAMOTO KIMITOSHI; MIYOSHI HIDEHITO

  生化学, 25 Aug. 2002

  
• 大腸菌巨大化細胞を用いた呼吸鎖のプロトンポンプの解析

  KURODA TERUO; KAWASAKI HISASHI; MOGI HARUYUKI; MIYOSHI HIDEHITO; TSUCHIYA TOMOFUSA; YABE ISAMU

  生化学, 25 Aug. 2002

  
• 大腸菌巨大化細胞を用いた呼吸鎖のプロトンポンプ活性の解析

  KURODA TERUO; KAWASAKI HISASHI; MOGI TATSUSHI; MIYOSHI HIDEHITO; TSUCHIYA TOMOFUSA; YABE ISAMU

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• Caenorhabditis elegans clk‐1長寿変異株におけるユビキノン生合成系の変動

  MIYADERA HIROKO; HIRAISHI AKIRA; KO HIKARU; MURAYAMA KIMIE; MIYOSHI HIDEHITO; SAKAMOTO KIMITOSHI; ISHII NAOAKI; LEVAVASSEUR F; KITA KIYOSHI

  日本ミトコンドリア研究会年会要旨集, 31 Jan. 2002

  
• Isolation, structure, and biological activity of a new NADH-fumarate reductase inhibitor, nafuredin, produced by Aspergillus niger.

  SHIOMI KAZURO; UI HIDEAKI; YAMAGUCHI YUICHI; MASUMA ROKURO; NAMIKOSHI MICHIO; KITA KIYOSHI; MIYOSHI HIDETO; HARDER A; OMURA SATOSHI

  天然有機化合物討論会講演要旨集, 01 Sep. 2001

  
• 酢酸菌のキノヘモプロテインアルコール脱水素酵素におけるユビキノン反応部位のアジドキノン標識法による同定

  MIZUGUCHI MITSUHIRO; TOYAMA HIROHIDE; ADACHI OSAO; MATSUSHITA KAZUNOBU; SAKAMOTO KIMITOSHI; MIYOSHI HIDEHITO

  生化学, 25 Aug. 2001

  
• 新規抗寄生虫物質nafuredinとその作用点

  UI HIDEAKI; MIYADERA HIROKO; YAMAGUCHI YUICHI; SHIOMI KAZURO; NAMIKOSHI MICHIO; MIYOSHI HIDETO; HARDER A; KITA KIYOSHI; OMURA SATOSHI

  微生物シンポジウム講演要旨集, 24 Aug. 2001

  
• P105W4-6 Novel anthelmintic compound nafuredin has selective inhibition to electron transport complex I of helminth mitochondria

  MIYADERA Hiroko; UI Hideaki; SHIOMI Kazuro; YAMAGUCHI Yuichi; MASUMA Rokuro; IWAI Yuzuru; MIYOSHI Hideto; HARDER Achim; KOELBL Heinz; OMURA Satoshi; KITA Kiyoshi

  Medical entomology and zoology, 04 Apr. 2001

  
• Altered Quinone Biosynthesis in the Long-lived clk-1 Mutants of Caenorhabditis elegans

  Hiroko Miyadera; Hisako Amino; Akira Hiraishi; Hikari Taka; Kimie Murayama; Hideto Miyoshill; Kimitoshi Sakamoto; Naoaki Ishii; Siegfried Hekimi; Kiyoshi Kita

  Journal of Biological Chemistry, 16 Mar. 2001

  
• 線虫長寿命変異株clk‐1におけるキノン組成の解析

  MIYADERA HIROKO; TAKA HIKARI; MURAYAMA KIMIE; MIYOSHI HIDETO; ISHII NAOAKI; HEKIMI J; KITA KIYOSHI

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2000

  
• 回虫ミトコンドリア複合体Iの選択的阻害剤nafuredinとその阻害機構

  MIYADERA HIROKO; UI HIDEAKI; SHIOMI KAZUAKI; IWAI YUZURU; OMURA SATOSHI; HARDER A; KOELBL H; MIYOSHI HIDETO; KITA KIYOSHI

  生化学, 25 Aug. 2000

  
• 酢酸菌のキノヘモプロテインアルコール脱水素酵素におけるユビキノン反応部位の解析

  MIZUGUCHI MITSUHIRO; TOYAMA HIROHIDE; ADACHI KAZUO; MATSUSHITA KAZUNOBU; SAKAMOTO KIMITOSHI; MIYOSHI HIDETO

  生化学, 25 Aug. 2000

  
• 巨大化大腸菌を用いた呼吸鎖のプロトンポンプ活性の解析

  KURODA TERUO; KAWASAKI HISASHI; SAMUKAWA TAKETO; MOTEGI TATSUSHI; MIYOSHI HIDETO; TSUCHIYA TOMOFUSA; YABE ISAMU

  生化学, 25 Aug. 2000

  
• ミトコンドリア複合体‐I阻害剤Acetogenin類の構造活性相関研究

  MIYOSHI HIDEHITO; KUWABARA KAORU; TAKADA MOTOYUKI; IWATA JUN; TATSUMOTO KARIN; SAKAMOTO KIMITOSHI; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, 27 Mar. 2000

  
• 新規殺虫剤IKF‐916の作用機構

  MITANI SHIGERU; ARAKI SATOSHI; TAKII YASUKO; OSHIMA TAKESHI; MURAI SHIGEO; MATSUO NORIFUSA; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, 27 Mar. 2000

  
• ミトコンドリア複合体‐Iに作用するピリジニウム型阻害剤の作用機構

  IWATA JUN; MIYOSHI HIDETO; SAKAMOTO KIMITOSHI; IWAMURA HITOSHI

  日本農薬学会大会講演要旨集, 01 Mar. 1999

  
• 呼吸鎖電子伝達系キノン・コネクションの生物有機化学的研究

  MIYOSHI HIDETO

  日本農芸化学会関西支部講演会講演要旨集, 06 Feb. 1999

  
• Structural and functional properties of ubiquinone redox sites in respiratory enzymes

  H Miyoshi

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, Dec. 1998

  
• 嫌気環境への適応に伴う呼吸鎮電子伝達系複合体II(コハク酸脱水素酵素)の分子進化

  MIYADERA HIROKO; HIRAISHI AKIRA; MIYOSHI HIDETO; SAKAMOTO KIMITOSHI; MATSUURA KATSUMI; KOJIMA SOMEI; KITA KIYOSHI

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• Research on the effect of flower bud inductive materials on mitochondrion energy metabolic system.

  MIYOSHI HIDETO

  松らい科学技術振興財団研究報告集, 01 Mar. 1998

  
• Specific interaction of cytokinins and their analogs with rotenone-sensitive internal NADH dehydrogenase in potato tuber mitochondria.

  M Sue; H Miyoshi; H Iwamura

  PLANT PHYSIOLOGY, Jul. 1997

  
• Studies on Nonel Salicylanilide Fungicides. (II): Fungicidal Spectrum and Activity against Tomato Late Blight.

  SAGAYAMA KAZUMI; KOMURA TOMOZO; YAMAGUCHI KUNIO; YASUDOMI NORIO; TAKAGI YASUSHI; MIYOSHI HIDETO; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, Mar. 1997

  
• Study on electron-transfer mechanism in mitochondrial complex-I using specific inhibitors and synthetic ubiquinones.

  MIYOSHI HIDETO; OSHIMA MICHIYO; INOUE MAKOTO; SAKAMOTO KIMITOSHI; IWATA ATSUSHI; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, Mar. 1997

  
• Studies on Novel Salicylanilide Fungicides. (I): Synthesis and Activity.

  MANABE KAN; ENDO YOSHINORI; ENDO YASUHIRO; SAGAYAMA KAZUMI; YAMAGUCHI KUNIO; TAKAGI YASUSHI; MIYOSHI HIDETO; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, Mar. 1997

  
• Mode of Action of AKD-2023 in Mitochondorial Electron Transport.

  KOURA YOKO; KINOSHITA SACHIKO; MATSUMOTO SHOGO; MIYOSHI HIDETO

  日本農薬学会大会講演要旨集, Mar. 1997

  
• 大腸菌チトクロムbo型ユビキノール酸化酵素のQ_H部位の生化学的解析

  SATO MARIKO; MOGI TATSUYUKI; MIYOSHI HIDETO; ANRAKU YASUHIRO

  生体エネルギー研究会討論会講演要旨集, 1997

  
• Cytochrome bc1 complex inhibition mechanism of the synthetic antimycin ( comparison with natural antimycin ).

  TAGAMI ETSUKO; MITSUYOSHI HIDETO; IWAMURA HAJIME

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1996

  
• Analysis of ubiquinol oxidation site of Escherichia coli cytochrome bo type terminal oxidase.

  SATO MARIKO; MOGI TATSUSHI; MIYOSHI HIDETO; ANRAKU YASUHIRO

  日本分子生物学会年会プログラム・講演要旨集, Jul. 1996

  
• 合成ユビキノン類縁体を用いた酢酸菌アルコール脱水素酵素の機能解明 : 有機化学・天然物化学

  田上 悦子; 坂元 君年; 三芳 秀人; 岩村 俶; 松下 一信; 薬師 寿治; 足立 収生

  日本農藝化學會誌, 05 Mar. 1996

  
• 大腸菌グルコース脱水素酵素のユビキノン結合部位の解析 : 酵素

  谷口 摩里子; 前山 道子; 印部 久代; 松下 一信; 山田 守; 足立 収生; 坂元 君年; 三芳 秀人

  日本農藝化學會誌, 05 Mar. 1996

  
• Synthesis of MPP+ analogues and mode of action study.

  INOUE MAKOTO; MIYOSHI HIDETO; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, Mar. 1996

  
• 合成ユビキノール類縁体を用いた大腸菌末端酸化酵素の基質酸化部位の解析

  MIYOSHI HIDEHITO; SAKAMOTO KIMITOSHI; IWAMURA HAJIME; SATO MARIKO; MOGI TATSUSHI; ANRAKU YASUHIRO

  生体エネルギー研究会討論会講演要旨集, 1996

  
• Inhibition of plant mitochondrial complex I by cytokinins and their analogues.

  SUE MASAYUKI; MIYOSHI HIDETO; IWAMURA HAJIME

  植物化学調節学会研究発表記録集, 1996

  
• Synthesis of short chain ubiquinone analogue and evaluation of electron transporting activity.

  SAKAMOTO KIMITOSHI; MIYOSHI HIDETO; IWAMURA HAJIME

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1995

  
• Inhibitors and Respiratory Electron-Transport Mechanism.

  MIYOSHI HIDETO

  化学と生物, Mar. 1995

  
• Inhibitory mechanism for mitochondrial respiratory chain of phytotoxins produced by phytopathogen Bipolaris bicolor.

  UENO HIDEKI; YAMASHITA ATSUKO; MIYOSHI HIDETO; IWAMURA HAJIME; MIYAKAWA HISASHI; UENO TAMIO; LIM C H

  日本農薬学会大会講演要旨集, Mar. 1995

  
• Study on Electron-Transfer Mechanism of Mitochondrial Complex I.

  UENO HIDEKI; INOUE MAKOTO; MIYOSHI HIDETO; IWAMURA HAJIME

  日本農薬学会大会講演要旨集, Mar. 1995

  
• New inhibitor to plant mitochondrion electron transfer chain.

  SUE MASAYUKI; MIYOSHI HIDETO; IWAMURA KIYOSHI

  植物化学調節学会研究発表記録集, 1995

  
• COMPARISON OF THE INHIBITORY-ACTION OF NATURAL ROTENONE AND ITS STEREOISOMERS WITH VARIOUS NADH-UBIQUINONE REDUCTASES

  H UENO; H MIYOSHI; K EBISUI; H IWAMURA

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Oct. 1994

  
• 電子伝達阻害剤Capsaicinの作用機構

  佐藤卓士; 三芳秀人; 岩村あつし

  日本農芸化学会誌, Mar. 1994

  
• ミトコンドリア電子伝達複合体間の直接的相互作用

  山下敦子; 三芳秀人; 岩村あつし

  日本農芸化学会誌, Mar. 1994

  
• フロログルシノール誘導体による光合成機能の調節

  猿田智勇; 前島晃; 米山弘一; 近内誠登; 三芳秀人; 阿部知子; 吉田茂男

  日本農芸化学会誌, Mar. 1994

  
• 合成ロテノン類縁体を用いたミトコンドリアNADH‐ユビキノン酸化還元酵素の機能解明

  植野英樹; 三芳秀人; 岩村あつし

  日本農芸化学会誌, Mar. 1994

  
• Functional Role of the High Affinity-quinone Binding Site of the Cytochrome bo Complex.

  SATO MARIKO; MOGI TATSUSHI; ITO SHIGERU; MATSUURA KATSUMI; MIYOSHI HIDETO; IWAMURA HAJIME; ANRAKU YASUHIRO

  生体エネルギー研究会討論会講演要旨集, 1994

  
• Possibility and the problems of the agricultural chemicals development targeting respiratory system.

  MIYOSHI HIDETO

  農薬, Oct. 1993

  
• アンチマイシンA類縁体のシトクロムbc1複合体阻害活性の解析

  徳竹伸哉; 三芳秀人; 佐藤卓士; 岩村はじめ

  日本農芸化学会関西支部講演会講演要旨集, Oct. 1993

  
• Ubiquinol Binding Sites of the Cytochrome bo Complex in Escherichia coli.

  WATANABE MARIKO; MOGI TATSUSHI; ANRAKU YASUHIRO; MIYOSHI HIDETO; IWAMURA HAJIME

  生体エネルギー研究会討論会講演要旨集, 1993

  
• Molecular Structure of the Reaction Center and Proton Translocation Mechanism in Redox-coupled Proton Pump.

  MOGI TATSUSHI; YOSHIKAWA SHIN'YA; HORI HIROSHI; UNO KIMIYUKI; OGURA TAKASHI; NISHIMURA YOSHIFUMI; MIYOSHI HIDETO; ISHIZUKA MORIO; OGURA KYOZO

  生体エネルギー研究会討論会講演要旨集, 1993

  
• Structural Factors of Antimycin A Molecule Required for Inhibitory Action.

  MIYOSHI HIDETO; TOKUTAKE NOBUYA; IWAMURA HAJIME

  生体エネルギー研究会討論会講演要旨集, 1993

  
• EVALUATION OF UNCOUPLING ACTIVITIES OF PHENOL DERIVATIVES BY USING A LIPID MEMBRANE-COATED QUARTZ CRYSTAL MICROBALANCE

  H EBATO; Y OKAHATA; T FUJITA; H MIYOSHI

  NIPPON KAGAKU KAISHI, 1993

  
• Mode of Action of Uncoupler and Mechanism of Oxidative Phosphorylation.

  MIYOSHI HIDETO

  生物物理, Apr. 1992

  
• Correlation Analysis for Acid Dissociation Constants of Multi-substituted Diphenyl- and Phenylpyridylamines.

  KAKUTAKU KEN; MIYOSHI HIDETO; FUJITA TOSHIO; KOMYOJI TERUMASA; HAGA TAKAHIRO

  情報化学討論会・構造活性相関シンポジウム講演要旨集, Nov. 1990

  
• Correlation between uncoupling activities of phenol-derivative uncouplers and partition coefficients into lipid matrix.

  EHATO HIROSHI; OKAHATA YOSHIO; FUJITA TOSHIO; MIYOSHI HIDETO

  高分子学会予稿集, Oct. 1990

  
• Action mechanism of uncoupling agents.

  MIYOSHI HIDETO; FUJITA TOSHIO

  化学, Oct. 1989

  
• Quantitative analysis of partition coefficient of substituted phenols in loposome/water system.

  MIYOSHI HIDETO; TOKUTAKE NOBUYA; FUJITA TOSHIO

  情報化学討論会・構造活性相関シンポジウム講演要旨集, Nov. 1988

  

Awards

• 1998

  日本農芸化学会, 日本農芸化学会奨励賞Award for The Encouragement of Young Scientists (The Japan Society for Bioscience, Biotechnology and Agrochemistry, 1998)
• 2005

  日本農薬学会, 日本農薬学会業績賞Society Awards on Prominent Achievement (Pesticide Science Society of Japan, 2005)

External funds: Kakenhi

• Construct of the platform for developing antibiotics targeting Vibrio cholera NADH-ubiquinone oxidoreductase

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38040:Bioorganic chemistry-related

  Kyoto University

  三芳 秀人

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  呼吸鎖酵素;コレラ菌;コロルミシン;ユビキノン;抗菌剤;コレラ菌呼吸鎖酵素;NADH脱水素酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02130/
• Studies on the anaerobic metabolic switching control mechanisms for algal biomass development

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38030:Applied biochemistry-related

  Osaka Metropolitan University;Osaka Prefecture University

  Daisaku Ohta

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  脂質代謝;微細藻類;電子伝達経路;キノン類;藻類バイオマス;脂質合成;オルガネラ電子伝達;酸化還元レベル;還元的TCA回路;電子伝達;ミトコンドリア;嫌気的代謝;脂質生合成;ユーグレナ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K05844/
• Production of chemicals that suppress generation of ROS from mitochondrial respiratory chain.

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  HIDETO MIYOSHI

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  ミトコンドリア;活性酸素;ユビキノン;complex I;酸化ストレス;生体エネルギー;複合体 I;化学修飾;ミトコンドリア呼吸鎖酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22278/
• Elucidation of inhibitor-resistance mechanism of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholera

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38040:Bioorganic chemistry-related

  Kyoto University

  HIDETO MIYOSHI

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  呼吸鎖酵素;Na+-NQR;コレラ菌;抗菌剤;コロルミシン;NADH脱水素酵素;ユビキノン;生体エネルギー;Na+-輸送性NADH-キノン酸化還元酵素;薬剤耐性;NADH-キノン酸化還元酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02147/
• Analysis of lipid transfer mechanism and organelle interactions required for multifunction of lipids

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Wada Hajime

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  脂質;脂質輸送タンパク質;ホスファチジルコリン;コンタクトサイト;シロイヌナズナ;ゼニゴケ;葉緑体;小胞体;合成脂質プローブ分子;脂質輸送メカニズム;植物;生理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03692/
• Conversion of mitochondrial respiratory complex I to a light-driven proton pump by chemical modification

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hideto Miyoshi

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  生物制御化学;ミトコンドリア呼吸鎖酵素;複合体-I;タンパク質化学修飾;ミトコンドリア;化学修飾;ミトコンドリア呼吸鎖;光スイッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14914/
• Site-specific modification of respiratory complex I for single molecule analysis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hideto Miyoshi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  生物制御化学;呼吸鎖複合体-I;化学修飾;ユビキノン;ミトコンドリア呼吸鎖;トシル化学;複合体-I;ミトコンドリア;呼吸鎖;呼吸鎖酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26292060/
• Probing the intercellular traffic mechanism of ubiquinone using synthetic molecular probes

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Masatoshi MURAI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  ユビキノン;ミトコンドリア;光親和性標識;Click Chemistry;複合体-I;出芽酵母

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23780116/
• Study on the function of ND1 subunit, a key subunit of respiratory complex I

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hideto MIYOSHI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  細胞機能調節物質;ミトコンドリア呼吸鎖酵素;複合体-I;アセトゲニン;光親和性標識;トシルケミストリー;ミトコンドリア;阻害剤;呼吸鎖複合体-I;ND1サブユニット;呼吸鎖阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380064/
• Development of conductive quinone-modified Au-electrode enabling super-sensitive detection of the activities of mitochondrial respiratory enzymes

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hideto MIYOSHI

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  ミトコンドリア;呼吸鎖酵素;ユビキノン;修飾電極;修飾金電極;ミトコンドリア呼吸鎖酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658039/
• Synthetic study of novel antitumor agents

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Tetsuaki TANAKA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  抗がん剤;有機合成化学;生物活性物質;構造活性相関;構造活性相関研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390021/
• Exploring the function of membrane domain of mitochondrial complex-I on the basis of synthesis of inhibitor probes

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hideto MIYOSHI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  細胞機能調節物質;ミトコンドリア;複合体-I;光親和性標識;阻害剤;アセトゲニン;ND1サブユニット;呼吸鎖酵素;ペプチド化学;生体エネルギー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380068/
• ミトコンドリア複合体-I活性の光制御をめざした光応答性阻害剤の合成開発

  Grant-in-Aid for Exploratory Research

  Kyoto University

  三芳 秀人

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  ミトコンドリア;複合体-I;アセトゲニン;光制御;呼吸鎖酵素;呼吸鎖酵素阻害剤;光スイッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18658048/
• Study on respiratory enzyme complex I based on the organic synthesis of acetogenin analogues

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hideto MIYOSHI

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ミトコンドリア;呼吸鎖酵素阻害剤;アセトゲニン;複合体-I;呼吸鎖阻害剤, mitochondria;respiratory inhibitor;acetogenin;complex I

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17380073/
• 低酸素適応における寄生虫ミトコンドリア特異的呼吸酵素群の生理機能

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  北 潔

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  Ascaris suum;NADH-フマル酸還元系;ミトコンドリア;複合体I;複合体II;結晶化;立体構造解析;酸素適応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17209013/
• 呼吸鎖酵素のピンポイント電子移動観測を実現する導電性阻害剤修飾電極の開発

  Grant-in-Aid for Exploratory Research

  Kyoto University

  三芳 秀人

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  呼吸鎖酵素;阻害剤;修飾電極;電子移動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16658052/
• Synthesis of functional probes toward elucidation of the function of respiratory enzymes of Caenorhabditis elegans.

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Hideto MIYOSHI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  呼吸鎖阻害剤;呼吸鎖酵素;ミトコンドリア;アセトゲニン;構造活性相関, Respiratory Inhibitor;Respiratory Enzymes;Mitochondria

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15380083/
• Molecular organization and physiological functions of the respiratory chain specific for mitochondria from Plasmodium

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  Kiyoshi KITA

  From 01 Apr. 2002, To 31 Mar. 2006, Project Closed

  マラリア;ミトコンドリア;アピコプラスト;細胞分画;パーコール;トリパノソーマ;シアン耐性酸化酵素;アスコフラノン;GFP;構造活性相関;呼吸鎖;複合体II;薬剤開発;低酸素適応;コハク酸脱水素酵素, Malaria;Mitochondria;apicoplast;cell fractionation;percoll;Trypanosome;cyanide-resistant oxidase;asucofuranone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14021014/
• Physiological function of respiratory enzymes specific for parasite mitochondria in the adaptation to low oxygen tension

  Grant-in-Aid for Scientific Research (S)

  The University of Tokyo

  Kiyoshi KITA

  From 01 Apr. 2001, To 31 Mar. 2005, Project Closed

  ミトコンドリア;複合体II;NADH-フマル酸還元系;回虫;寄生虫;結晶解析;低酸素適応;ユビキノン生合成;NADH-フアル酸還元系;HIF-1;呼吸鎖;フマル酸還元酵素;ロドキノン, mitochondria;complex II;NADH-fumarate reductase;Ascaris suum;parasite;crystal structure analysis;adaptation to low oxygen tension;biosynthesis of ubiquinone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13854011/
• マラリア原虫ミトコンドリア特異的呼吸酵素群の分子構築と生理機能

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  The University of Tokyo

  北 潔

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  マラリア;ミトコンドリア;呼吸鎖;複合体II;薬剤開発;低酸素適応;コハク酸脱水酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13226015/
• Molecular Mechanism and Structural Basis of Ubiquinone-Redox Reaction in Bacterial Respiratory Chains

  Grant-in-Aid for Scientific Research (B)

  Yamaguchi University

  Kazunobu MATSUSHITA

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  アジドキノン;光親和性標識;ユビキノン;大腸菌グルコース脱水素酵素;酢酸菌アルコール脱水素酵素;バクテリア呼吸鎖;光親和性標識法;大腸菌チトクロムbo;呼吸鎖, Azidoquinone;Photo-affinity labeling;Ubiquinone;Escherichia coli Glucose dehydrogenase;Alcohol Dehydrogenase of acetic acid bacteria;Bacterial respiratory chain

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12460045/
• Study on ubiquinol reaction site of cytochrome bo in Escherichia coli.

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Hideto MIYOSHI

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  大腸菌末端酸化酵素;呼吸鎖酵素;ユビキノン;構造活性相関;オーラシン;呼吸鎖阻害剤, E.coli terminal oxidese;Respiratory enzymes;Ubiquinone;Structure-activity relation;Aurachin;Respiratory inhibitors

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11660108/
• 呼吸鎖金属酵素における共鳴ラマン測定のための^<13>C-標識ユビキノン類の有機合成

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  三芳 秀人

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ミトコンドリア;呼吸鎖電子伝達;生体エネルギー;ユビキノン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10129213/
• Structure and Function of Quinoprotein Dehydrogenase

  Grant-in-Aid for Scientific Research (B).

  Yamaguchi University

  Kazunobu MATSUSHITA

  From 01 Apr. 1997, To 31 Mar. 2000, Project Closed

  ピロロキノリンキノン;キノプロテイン脱水素酵素;グルコース脱水素酵素;アルコール脱水素酵素;X線構造解析;Pseudomonas putida;大腸菌;酢酸菌, Pyrroloquinoline quinone;Quinoprotein dehydrogenase;Glucose dehydrogenase;Alcohol Dehydrogenase;X ray crystallography;Pseudomonas putida;Escherichia coli;Acetic acid bacteria

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044228/
• Probing the ubiquinol oxidatiousite of Eschenchia col ubiquinol oxidases.

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Hideto MIYOSHI

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  呼吸鎖;ユビキノン;末端酸化酵素;構造活性相関, Respiratory chaiu;Ubiquinone;Terminal oxidase;Structure activity relation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08660136/
• DEVELOPMENT OF TERMINAL OXIDASE-SPECIFIC BACTERIOCIDES AND BIOCHEMICAL ANALYSIS OF THE SUBSTRATE OXIDATION MECHANISM

  Grant-in-Aid for Scientific Research (A)

  THE UNIVERSITY OF TOKYO

  Tatsushi MOGI

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  抗菌剤;末端酸化酵素;キノール酸化酵素;キノンアナログ;大腸菌;基質酸化部位;置換フェノール;反応機構;基質酸化機構;耐性変異;置換フェノール類;ユビキノン;活性評価システム;カプサイシン, Anti-bacteriocide;Terminal oxidase;Quinol oxidase;Quinone analogue;Escherichia coli;Substrate oxidation site;Substituted phenol;Reaction mechanism

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558221/
• Study on structure of cytochrome b using antimycin A-resistant mutants.

  Grant-in-Aid for General Scientific Research (C)

  KYOTO UNIVERSITY

  Hideto MIYOSHI

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  ミトコンドリア;ミトクロムbc_1;アンチマイシンA;シトクロムbc,;アンチマイシン;シトクロムb, mitochondria;cytochrome bcl;antimycin A

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06660132/
• Development of new classes of flower inducing compounds and their mechanism of action.

  Grant-in-Aid for General Scientific Research (B)

  KYOTO UNIVERSITY

  Hajime IWAMURA

  From 01 Apr. 1993, To 31 Mar. 1995, Project Closed

  花成誘導;アスパラガス;アサガオ;シトクロームP-450;カ-バメート;アミノオキシム;ポリアミン;アモノオキシム;P-450;カーバメー化合物, Flower induction;Asparagus;Morning glory;Cytochrome P-450;Carbamates;Aminooximes;Polyamines

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05453166/

External funds: others

• ミトコンドリア蛋白の構造種差に基づくアグロケミカルシーズ創生

  生研センター　イノベーション創出基礎的研究推進事業

  From 10 Aug. 2012, To 31 Mar. 2017

  三芳秀人

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Applied Life Sciences I

  CA01, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Chemistry of Biological Activity

  CA19, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Biofunction Chemistry Seminar

  CF09, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Biofunction Chemistry Seminar

  CF09, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Biofunction Chemistry

  CG09, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Biofunction Chemistry

  CG09, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Applied Life Sciences

  5801, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Bioorganic Chemistry II

  5630, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Applied Life Sciences I

  CA01, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Chemistry of Biological Activity

  CA19, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Biofunction Chemistry Seminar2

  CB36, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Biofunction Chemistry Seminar1

  CB35, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Biofunction Chemistry2

  CC36, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Biofunction Chemistry1

  CC35, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Bioorganic Chemistry II

  5630, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Biofunction Chemistry2

  CC36, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Biofunction Chemistry1

  CC35, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Biofunction Chemistry Seminar2

  CB36, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Applied Life Sciences I

  CA01, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Biofunction Chemistry Seminar1

  CB35, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Bioorganic Chemistry II

  5630, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Chemistry of Biological Activity

  CA19, Spring, Graduate School of Agriculture, 1
• From Apr. 2011, To Mar. 2012

  応用生命科学入門IV

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  生物有機化学II

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2011, To Mar. 2012

  生物機能制御化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  生物機能制御化学専攻演習

  農学研究科
• From Apr. 2012, To Mar. 2013

  Scientific English

  Spring, 農学部
• From Apr. 2012, To Mar. 2013

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Seminar in Applied Life Science I

  Spring, 農学部
• From Apr. 2013, To Mar. 2014

  Seminar in Applied Life Science II

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2013, To Mar. 2014

  Chemistry of Biological Activity

  Fall, 農学研究科
• From Apr. 2013, To Mar. 2014

  Biofunction Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course of Biofunction Chemistry

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Biofunction Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course of Biofunction Chemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Basic Organic Chemistry A

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Biofunction Chemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Biofunction Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2015, To Mar. 2016

  Fundamental Study on Agrochemicals

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Biofunction Chemistry

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Biofunction Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Biofunction Chemistry

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Biofunction Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences I

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Outline of Physiological Chemistry

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Applied Life Sciences I

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Applied Life Science IV

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2020, To Mar. 2021

  Scientific English

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Applied Life Sciences I

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Applied Life Sciences I

  Fall, 農学研究科
• From Apr. 2020, To Mar. 2021

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Applied Life Sciences I

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Bioorganic Chemistry II

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Experimental Course of Biofunction Chemistry1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course of Biofunction Chemistry2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Biofunction Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Biofunction Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Chemistry of Biological Activity

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Thesis

  Year-long, 農学部

Participation in PhD Defense

• 昆虫キチン合成酵素の新規阻害剤の設計および結合様式のin silico解析

  MORI KOTARO, Graduate School of Agriculture, Sub-chief Examiner

  25 Mar. 2024
• Studies on the structure and function of Na+-pumping NADH-quinone oxidoreductase from Vibrio cholerae

  FUKUDA MOE, Graduate School of Agriculture, Chief Examiner

  25 Mar. 2024
• ヒキガエル由来防御用毒性ステロイド bufadienolide 類を蓄積するヘビ・ヤマカガシの化学生態学的研究

  INOUE TAKATO, Graduate School of Agriculture, Sub-chief Examiner

  25 Mar. 2024
• ヒト脂質輸送体ABCA1のコレステロール認識機構に関する生化学研究

  SAKATA KAZUKI, Graduate School of Agriculture, Sub-chief Examiner

  25 Mar. 2024
• リンゴ果実における昆虫の食害に対する化学的防御応答の解明

  OHATA YUTO, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2023
• Development of Direct Electron Transfer-Type Cascade System by Alcohol and Aldehyde Dehydrogenases

  ADACHI TAIKI, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2023
• Characterization of bioactive peptides without disulfide bridges from the venom of Lycosa poonaensis species inhabiting the Egyptian environment

  Alhussin Mohamed Abdelhakeem Megaly, Graduate School of Agriculture, Sub-chief Examiner

  26 Sep. 2022
• 化学物質の分子サイズや代謝分解性に着目した生物濃縮性評価手法に関する研究

  MIYATA CHIYOKO, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2022
• Mode of action studies on pentenediols and tamoxifen with mitochondria

  UNTEN YUFU, Graduate School of Agriculture, Chief Examiner

  23 Mar. 2022
• Studies on the reaction mechanism of ubiquinone in respiratory complex I

  UNO SHINPEI, Graduate School of Agriculture, Chief Examiner

  23 Mar. 2022
• ABC蛋白質のATP共役機構と新規生理的役割に関する研究

  FUTAMATA RYOTA, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2022

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  教職教育委員会教職科目連絡小委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2024

  入学試験委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2025

  教職教育委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2024

  教職教育委員会教職科目連絡小委員会 委員
• From 01 Apr. 2009, To 31 Mar. 2011

  教職教育委員会 委員
• From 01 Apr. 2009, To 31 Mar. 2011

  身体障害学生相談室管理運営委員会 委員
• From 01 Apr. 2009, To 31 Mar. 2011

  教職科目連絡小委員会 委員
• From 01 Apr. 2009, To 31 Mar. 2013

  高等教育研究開発推進機構基礎教育専門委員会・化学部会 委員
• From 05 Jun. 2015, To 04 Jun. 2017

  入学者選抜方法研究委員会教科・科目部会（化学） 委員
• From 01 Apr. 2020, To 31 Mar. 2022

  農芸化学系 学系長

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  研究科教務委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2019

  研究科教務委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2019

  将来構想検討委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2021

  研究科教務委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2023

  将来構想検討委員会　委員
• From 01 Apr. 2021, To 31 Mar. 2022

  応用生命科学科長
• From 01 Apr. 2021, To 31 Mar. 2022

  評価委員会　委員