Basic Information

Concurrent Affiliation

• Graduate School of Advanced Integrated Studies in Human Survivability (GSAIS), 総合生存学専攻, 協力教員

Academic Degree

• 医学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 金沢大学, 医学部医学科, 卒業

High School

• High School

  徳島県立城南高等学校

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201401000731122588

researchmap URL

• https://researchmap.jp/7000008408

Research

Research Topics, Overview of the research

• Research Topics

  Drug development for currently incurable diseases, such as neurodegenerative disorders, incurable eye diseases, cancers, obesity-related diseases, cancers, etc.

• Overview of the research

  I believe that we could develop novel therapeutics effective for currently incurable diseases, e.g. neurodegenerative disorders, incurable eye diseases, cancers, obesity-related diseases, cancers, etc., from a view of why currently incurable diseases are incurable, but not a view of why currently incurable diseases occur.

Research Areas

• Life sciences, Pathobiochemistry

Papers

• ウサギ網膜色素変性症モデルにおけるVCP阻害剤の神経保護効果の検討

  村岡 勇貴; 池田 華子; 中野 紀子; 板谷 正紀; 近藤 峰生; 寺崎 浩子; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Mar. 2012

  
• VCP阻害剤によるマウス網膜神経節細胞傷害モデルにおける神経保護効果の検討

  中野 紀子; 池田 華子; 村岡 勇貴; 板谷 正紀; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Mar. 2012

  
• 網膜虚血再灌流におけるvalosin-containing protein modifierの神経保護効果の検討

  畑 匡侑; 池田 華子; 飯田 悠人; 吉川 宗光; 長谷川 智子; 村岡 勇貴; 垣塚 彰; 吉村 長久

  眼科臨床紀要, Oct. 2015

  
• 正常眼圧緑内障モデルマウスにおける分岐鎖アミノ酸の神経節細胞保護効果の検討

  長谷川 智子; 池田 華子; 村岡 勇貴; 垣塚 彰; 吉村 長久

  日本緑内障学会抄録集, Sep. 2015

  
• VCP modulatorのCCR2欠損マウスにおけるドルーゼン抑制の機序

  飯田 悠人; 池田 華子; 吉川 宗光; 畑 匡侑; 長谷川 智子; 村岡 勇貴; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Mar. 2015

  
• VCP阻害剤によるCCR2欠損マウスのドルーゼン抑制効果の検討

  村岡 勇貴; 池田 華子; 中野 紀子; 長谷川 智子; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Mar. 2013

  
• VCP阻害剤によるグラスト欠損マウスにおける神経保護効果の検討

  中野 紀子; 池田 華子; 村岡 勇貴; 板谷 正紀; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Mar. 2013

  
• VCP阻害剤によるDBA/2J緑内障モデルマウスにおける神経保護効果の検討

  池田 華子; 中野 紀子; 村岡 勇貴; 板谷 正紀; 垣塚 彰; 吉村 長久

  日本眼科学会雑誌, Jan. 2013

  
• KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats

  Sachiko Iwai; Hanako O. Ikeda; Hisashi Mera; Kohei Nishitani; Motoo Saito; Akitaka Tsujikawa; Akira Kakizuka

  Scientific Reports, Dec. 2021

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• 前立腺特異的かつ強力な遺伝子発現法の開発とその前立腺癌遺伝子治療への応用

  清川 岳彦; 筧 善行; 吉田 修; 成宮 周; 垣塚 彰

  日本泌尿器科学会雑誌, 1998

  
• VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells.

  Promise Ogor; Tomoki Yoshida; Masaaki Koike; Akira Kakizuka

  Genes to cells : devoted to molecular & cellular mechanisms, 25 May 2021

  
• Author Correction: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.

  Motoo Saito; Kohei Nishitani; Hanako O Ikeda; Shigeo Yoshida; Sachiko Iwai; Xiang Ji; Akihiro Nakahata; Akira Ito; Shinichiro Nakamura; Shinichi Kuriyama; Hiroyuki Yoshitomi; Koichi Murata; Tomoki Aoyama; Hiromu Ito; Hiroshi Kuroki; Akira Kakizuka; Shuichi Matsuda

  Scientific reports, 29 Mar. 2021

  
• 急性網膜神経節細胞障害モデルを用いたVCP ATPase阻害剤の神経保護メカニズム

  日下 真実; 長谷川 智子; 池田 華子; 岩井 祥子; 飯田 慶; 垣塚 彰; 辻川 明孝

  日本眼科学会雑誌, Mar. 2021

  
• Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

  Tomoko Hasegawa; Hanako O Ikeda; Sachiko Iwai; Norio Sasaoka; Akira Kakizuka; Akitaka Tsujikawa

  Scientific reports, 10 Dec. 2020

  
• A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.

  Motoo Saito; Kohei Nishitani; Hanako O Ikeda; Shigeo Yoshida; Sachiko Iwai; Xiang Ji; Akihiro Nakahata; Akira Ito; Shinichiro Nakamura; Shinichi Kuriyama; Hiroyuki Yoshitomi; Koichi Murata; Tomoki Aoyama; Hiromu Ito; Hiroshi Kuroki; Akira Kakizuka; Shuichi Matsuda

  Scientific reports, 27 Nov. 2020

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• Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis.

  Hiromi Imamura; Shuichiro Sakamoto; Tomoki Yoshida; Yusuke Matsui; Silvia Penuela; Dale W Laird; Shin Mizukami; Kazuya Kikuchi; Akira Kakizuka

  eLife, 14 Oct. 2020

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• 新規VCP ATPase阻害剤であるKUS121は小胞体ストレス応答抑制を介した軟骨細胞死抑制作用により関節軟骨保護作用を有する

  斉藤 元央; 西谷 江平; 池田 華子; 伊藤 宣; 岩井 祥子; 季 翔; 村田 浩一; 青山 朋樹; 黒木 裕士; 垣塚 彰; 松田 秀一

  日本整形外科学会雑誌, Sep. 2020

  
• Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.

  Tomoko Hasegawa; Hanako Ohashi Ikeda; Norimoto Gotoh; Kei Iida; Sachiko Iwai; Noriko Nakano; Akira Kakizuka; Akitaka Tsujikawa

  Scientific reports, 06 Mar. 2020, Peer-reviewed

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• Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial.

  Hanako Ohashi Ikeda; Yuki Muraoka; Masayuki Hata; Eriko Sumi; Takafumi Ikeda; Takayuki Nakagawa; Hiroyasu Abe; Harue Tada; Satoshi Morita; Akira Kakizuka; Nagahisa Yoshimura; Akitaka Tsujikawa

  PloS one, 2020, Peer-reviewed

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• OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells.

  Tomoki Yoshida; Hitomi Nakajima; Sena Takahashi; Akira Kakizuka; Hiromi Imamura

  ACS sensors, 27 Dec. 2019, Peer-reviewed

  
• PPARα-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory

  Soaad Alfaqaan; Tomoki Yoshida; Hiromi Imamura; Chihiro Tsukano; Yoshiji Takemoto; Akira Kakizuka

  Scientific Reports, 01 Dec. 2019, Peer-reviewed

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• Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells

  Yi Hsun Tan; Toshiyuki Shudo; Tomoki Yoshida; Yuma Sugiyama; Jia Ying Si; Chihiro Tsukano; Yoshiji Takemoto; Akira Kakizuka

  Genes to Cells, 01 Nov. 2019, Peer-reviewed

  
• Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E₂ synthesis in the brain and their behavioral relevance.

  Nie X; Kitaoka S; Shinohara M; Kakizuka A; Narumiya S; Furuyashiki T

  Scientific reports, Nov. 2019, Peer-reviewed

  
• Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.

  Ide Y; Horie T; Saito N; Watanabe S; Otani C; Miyasaka Y; Kuwabara Y; Nishino T; Nakao T; Nishiga M; Nishi H; Nakashima Y; Nakazeki F; Koyama S; Kimura M; Tsuji S; Rodriguez RR; Xu S; Yamasaki T; Watanabe T; Yamamoto M; Yanagita M; Kimura T; Kakizuka A; Ono K

  JACC. Basic to translational science, Oct. 2019, Peer-reviewed

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• KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion.

  Hisanori Kinoshita; Takakuni Maki; Ken Yasuda; Natsue Kishida; Norio Sasaoka; Yasushi Takagi; Akira Kakizuka; Ryosuke Takahashi

  Scientific reports, 08 Aug. 2019, Peer-reviewed

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• Emodin, as a mitochondrial uncoupler, induces strong decreases in ATP levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.

  Sugiyama Y; Shudo T; Hosokawa S; Watanabe A; Nakano M; Kakizuka A

  Genes to cells : devoted to molecular & cellular mechanisms, Jun. 2019, Peer-reviewed

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• A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation

  Norio Sasaoka; Hiromi Imamura; Akira Kakizuka

  iScience, Dec. 2018, Peer-reviewed

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• The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.

  Nie X; Kitaoka S; Tanaka K; Segi-Nishida E; Imoto Y; Ogawa A; Nakano F; Tomohiro A; Nakayama K; Taniguchi M; Mimori-Kiyosue Y; Kakizuka A; Narumiya S; Furuyashiki T

  Neuron, 08 Aug. 2018, Peer-reviewed

  
• Corrigendum to "Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma" [Heliyon 4(2) (March 2018) e00544].

  Tomoko Hasegawa; Hanako Ohashi Ikeda; Sachiko Iwai; Yuki Muraoka; Tatsuaki Tsuruyama; Keiko Okamoto-Furuta; Haruyasu Kohda; Akira Kakizuka; Nagahisa Yoshimura

  Heliyon, Aug. 2018, Peer-reviewed

  
• In vivo targeted single-nucleotide editing in zebrafish.

  Tanaka S; Yoshioka S; Nishida K; Hosokawa H; Kakizuka A; Maegawa S

  Scientific reports, 30 Jul. 2018, Peer-reviewed

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• KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration.

  Yuki Muraoka; Yuto Iida; Hanako O Ikeda; Sachiko Iwai; Masayuki Hata; Takeshi Iwata; Mao Nakayama; Nobuhiro Shimozawa; Yuko Katakai; Akira Kakizuka; Nagahisa Yoshimura; Akitaka Tsujikawa

  Heliyon, May 2018, Peer-reviewed

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• Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma.

  Tomoko Hasegawa; Hanako Ohashi Ikeda; Sachiko Iwai; Yuki Muraoka; Tatsuaki Tsuruyama; Keiko Okamoto-Furuta; Haruyasu Kohda; Akira Kakizuka; Nagahisa Yoshimura

  Heliyon, Feb. 2018, Peer-reviewed

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• Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation.

  Masaki Matsubara; Hajime Kanda; Hiromi Imamura; Mayumi Inoue; Michio Noguchi; Kiminori Hosoda; Akira Kakizuka; Kazuwa Nakao

  Scientific reports, 17 Jan. 2018, Peer-reviewed

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• A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

  Yumi Konagaya; Kenta Terai; Yusuke Hirao; Kanako Takakura; Masamichi Imajo; Yuji Kamioka; Norio Sasaoka; Akira Kakizuka; Kenta Sumiyama; Tomoichiro Asano; Michiyuki Matsuda

  CELL REPORTS, Nov. 2017, Peer-reviewed

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• ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

  Masaki Nakano; Hiromi Imamura; Norio Sasaoka; Masamichi Yamamoto; Norihito Uemura; Toshiyuki Shudo; Tomohiro Fuchigami; Ryosuke Takahashi; Akira Kakizuka

  EBIOMEDICINE, Aug. 2017, Peer-reviewed

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• KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress

  Masayuki Hata; Hanako O. Ikeda; Chinami Kikkawa; Sachiko Iwai; Yuki Muraoka; Tomoko Hasegawa; Akira Kakizuka; Nagahisa Yoshimura

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells

  Tomoki Yoshida; Akira Kakizuka; Hiromi Imamura

  SCIENTIFIC REPORTS, Dec. 2016, Peer-reviewed

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• Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration

  Tomoko Hasegawa; Yuki Muraoka; Hanako Ohashi Ikeda; Tatsuaki Tsuruyama; Mineo Kondo; Hiroko Terasaki; Akira Kakizuka; Nagahisa Yoshimura

  Scientific Reports, Aug. 2016, Peer-reviewed

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• Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics

  Masae Ikura; Kanji Furuya; Atsuhiko Fukuto; Ryo Matsuda; Jun Adachi; Tomonari Matsuda; Akira Kakizuka; Tsuyoshi Ikura

  MOLECULAR AND CELLULAR BIOLOGY, May 2016, Peer-reviewed

  
• Neuroprotective effects of VCP modulators in mouse models of glaucoma

  Noriko Nakano; Hanako Ohashi Ikeda; Tomoko Hasegawa; Yuki Muraoka; Sachiko Iwai; Tatsuaki Tsuruyama; Masaki Nakano; Tomohiro Fuchigami; Toshiyuki Shudo; Akira Kakizuka; Nagahisa Yoshimura

  Heliyon, 01 Apr. 2016, Peer-reviewed

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• Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

  Shun Matsuda; Jun Adachi; Masaru Ihara; Nobuhiro Tanuma; Hiroshi Shima; Akira Kakizuka; Masae Ikura; Tsuyoshi Ikura; Tomonari Matsuda

  NUCLEIC ACIDS RESEARCH, Jan. 2016, Peer-reviewed

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• Identification of a New Type of Covalent PPAR gamma Agonist using a Ligand-Linking Strategy

  Anna Ohtera; Yusaku Miyamae; Kotaro Yoshida; Kazuhiro Maejima; Toru Akita; Akira Kakizuka; Kazuhiro Irie; Seiji Masuda; Taiho Kambe; Masaya Nagao

  ACS CHEMICAL BIOLOGY, Dec. 2015, Peer-reviewed

  
• Suppression of Drusen-like Deposits by a Novel VCP modulator in CCR2 Deficient Mice

  Yuki Muraoka; Hanako Ohashi Ikeda; Yuto Iida; Masayuki Hata; Tomoko Hasegawa; Munemitsu Yoshikawa; Akira Kakizuka; Nagahisa Yoshimura

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Jun. 2015, Peer-reviewed

  
• VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast

  Yohei Ohnuma; Takahiro Takata; Junko Kawawaki; Kunihiko Yasuda; Keiji Tanaka; Yoko Kimura; Akira Kakizuka

  FEBS LETTERS, Feb. 2015, Peer-reviewed

  
• VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders

  Kakizuka A; Nakao K; Minato N; Uemoto S

  2015, Peer-reviewed

  
• Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging

  Hideyuki Yaginuma; Shinnosuke Kawai; Kazuhito V. Tabata; Keisuke Tomiyama; Akira Kakizuka; Tamiki Komatsuzaki; Hiroyuki Noji; Hiromi Imamura

  SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed

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• Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa

  Hanako Ohashi Ikeda; Norio Sasaoka; Masaaki Koike; Noriko Nakano; Yuki Muraoka; Yoshinobu Toda; Tomohiro Fuchigami; Toshiyuki Shudo; Ayana Iwata; Seiji Hori; Nagahisa Yoshimura; Akira Kakizuka

  SCIENTIFIC REPORTS, Aug. 2014, Peer-reviewed

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• Neuroprotective effect of KUS121, a VCP modulator, on a rat model of ischemia and reperfusion-induced retinal degeneration.

  Hata Masayuki; Ikeda Hanako Ohashi; Yoshikawa Munemitsu; Hasegawa Tomoko; Nakano Noriko; Muraoka Yuki; Kakizuka Akira; Yoshimura Nagahisa

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Apr. 2014, Peer-reviewed

  
• Suppression of Drusen-like Deposits by a Novel VCP modulator in CCR2 Deficient Mice

  Muraoka Yuki; Ikeda Hanako Ohashi; Nakano Noriko; Hasegawa Tomoko; Hata Masayuki; Yoshikawa Munemitsu; Kakizuka Akira; Yoshimura Nagahisa

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Apr. 2014, Peer-reviewed

  
• Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca(2+) influx and subsequent Ca(2+) oscillations.

  Tanaka Takashi; Nagashima Kazuaki; Inagaki Nobuya; Kioka Hidetaka; Takashima Seiji; Fukuoka Hajime; Noji Hiroyuki; Kakizuka Akira; Imamura Hiromi

  The Journal of biological chemistry, 24 Jan. 2014

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• Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+ Influx and Subsequent Ca2+ Oscillations

  Takashi Tanaka; Kazuaki Nagashima; Nobuya Inagaki; Hidetaka Kioka; Seiji Takashima; Hajime Fukuoka; Hiroyuki Noji; Akira Kakizuka; Hiromi Imamura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2014, Peer-reviewed

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• Long-Term Oral Administration of Hop Flower Extracts Mitigates Alzheimer Phenotypes in Mice

  Norio Sasaoka; Megumi Sakamoto; Shoko Kanemori; Michiru Kan; Chihiro Tsukano; Yoshiji Takemoto; Akira Kakizuka

  PLOS ONE, Jan. 2014, Peer-reviewed

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• タンパク質の品質管理と神経変性

  木村洋子; 垣塚 彰

  Annual Review神経, 2014

  
• ホップ抽出液のアルツハイマー病発症抑制効果

  笹岡紀男; 垣塚 彰

  2014

  
• Mdm20 Stimulates PolyQ Aggregation via Inhibiting Autophagy Through Akt-Ser473 Phosphorylation

  Kunihiko Yasuda; Kyoji Ohyama; Kazuko Onga; Akira Kakizuka; Nozomu Mori

  PLOS ONE, Dec. 2013, Peer-reviewed

  
• Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system

  Yoko Kimura; Junpei Fukushi; Seiji Hori; Noriyuki Matsuda; Kei Okatsu; Yukie Kakiyama; Junko Kawawaki; Akira Kakizuka; Keiji Tanaka

  GENES TO CELLS, Dec. 2013, Peer-reviewed

  
• Prostaglandin E Receptor EP1 Forms a Complex with Dopamine D1 Receptor and Directs D1-Induced cAMP Production to Adenylyl Cyclase 7 through Mobilizing G(beta gamma) Subunits in Human Embryonic Kidney 293T Cells

  Aliza T. Ehrlich; Tomoyuki Furuyashiki; Shiho Kitaoka; Akira Kakizuka; Shuh Narumiya

  MOLECULAR PHARMACOLOGY, Sep. 2013, Peer-reviewed

  
• In Vivo Fluorescent Adenosine 5'-Triphosphate (ATP) Imaging of Drosophila melanogaster and Caenorhabditis elegans by Using a Genetically Encoded Fluorescent ATP Biosensor Optimized for Low Temperatures

  Taiichi Tsuyama; Jun-ichi Kishikawa; Yong-Woon Han; Yoshie Harada; Asako Tsubouchi; Hiroyuki Noji; Akira Kakizuka; Ken Yokoyama; Tadashi Uemura; Hiromi Imamura

  ANALYTICAL CHEMISTRY, Aug. 2013, Peer-reviewed

  
• Neuroprotective effect of VCP inhibitors on mice models of glaucoma

  Ikeda Hanako; Nakano Noriko; Muraoka Yuki; Hangai Masanori; Kakizuka Akira; Yoshimura Nagahisa

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Jun. 2013, Peer-reviewed

  
• A Novel Valosin-Containing Protein Inhibitor Suppresses Photoreceptor Degeneration in a Rabbit Model of Retinitis Pigmentosa

  Muraoka Yuki; Ikeda Hanako; Nakano Noriko; Hasegawa Tomoko; Kakizuka Akira; Yoshimura Nagahisa

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Jun. 2013, Peer-reviewed

  
• VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels

  Katsuhiro Murakami; Yuzuru Ichinohe; Masaaki Koike; Norio Sasaoka; Shun-ichiro Iemura; Tohru Natsume; Akira Kakizuka

  PLOS ONE, Feb. 2013, Peer-reviewed

  
• 神経変性疾患と細胞死

  垣塚 彰

  医学の歩み, 2013

  
• In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells

  Hidetoshi Sakurai; Yasuko Sakaguchi; Emi Shoji; Tokiko Nishino; Izumi Maki; Hiroshi Sakai; Kazunori Hanaoka; Akira Kakizuka; Atsuko Sehara-Fujisawa

  PLOS ONE, Oct. 2012, Peer-reviewed

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• Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs

  Takahiro Takata; Yoko Kimura; Yohei Ohnuma; Junko Kawawaki; Yukie Kakiyama; Keiji Tanaka; Akira Kakizuka

  JOURNAL OF STRUCTURAL BIOLOGY, Aug. 2012, Peer-reviewed

  
• Real-Time Imaging of Rabbit Retina with Retinal Degeneration by Using Spectral-Domain Optical Coherence Tomography

  Yuki Muraoka; Hanako Ohashi Ikeda; Noriko Nakano; Masanori Hangai; Yoshinobu Toda; Keiko Okamoto-Furuta; Haruyasu Kohda; Mineo Kondo; Hiroko Terasaki; Akira Kakizuka; Nagahisa Yoshimura

  PLOS ONE, Apr. 2012, Peer-reviewed

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• Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: Implications for co-operative versus non-co-operative actions of Mdm20 and Nat5

  Kyoji Ohyama; Kunihiko Yasuda; Kazuko Onga; Akira Kakizuka; Nozomu Mori

  GENE EXPRESSION PATTERNS, Jan. 2012, Peer-reviewed

  
• Longitudinal and Simultaneous Imaging of Retinal Ganglion Cells and Inner Retinal Layers in a Mouse Model of Glaucoma Induced by N-Methyl-D-Aspartate

  Noriko Nakano; Hanako Ohashi Ikeda; Masanori Hangai; Yuki Muraoka; Yoshinobu Toda; Akira Kakizuka; Nagahisa Yoshimura

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Nov. 2011, Peer-reviewed

  
• Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain

  Yukio Takeshita; Ryutaro Fujinaga; Keiji Kokubu; Md. Nabiul Islam; Mir Rubayet Jahan; Akie Yanai; Akira Kakizuka; Koh Shinoda

  NEUROREPORT, Mar. 2011, Peer-reviewed

  
• Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells

  Keiko Muguruma; Ayaka Nishiyama; Yuichi Ono; Hiroyuki Miyawaki; Eri Mizuhara; Seiji Hori; Akira Kakizuka; Kunihiko Obata; Yuchio Yanagawa; Tomoo Hirano; Yoshiki Sasai

  NATURE NEUROSCIENCE, Oct. 2010, Peer-reviewed

  
• Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia

  Atsushi Manno; Masakatsu Noguchi; Junpei Fukushi; Yasuhiro Motohashi; Akira Kakizuka

  GENES TO CELLS, Aug. 2010, Peer-reviewed

  
• Valosin-containing Protein (VCP) in Novel Feedback Machinery between Abnormal Protein Accumulation and Transcriptional Suppression

  Masaaki Koike; Junpei Fukushi; Yuzuru Ichinohe; Naoki Higashimae; Masahiko Fujishiro; Chiyomi Sasaki; Masahiro Yamaguchi; Toshiki Uchihara; Saburo Yagishita; Hiroshi Ohizumi; Seiji Hori; Akira Kakizuka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2010, Peer-reviewed

  
• Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress

  Akihiko Okamoto; Masaaki Koike; Kunihiko Yasuda; Akira Kakizuka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2010, Peer-reviewed

  
• Glucosamine induces autophagy via an mTOR-independent pathway

  Tomoya Shintani; Fumiyoshi Yamazaki; Toshihiko Katoh; Midori Umekawa; Yoshiharu Matahira; Seiji Hori; Akira Kakizuka; Kazuhide Totani; Kenji Yamamoto; Hisashi Ashida

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2010, Peer-reviewed

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• VCP, involved in aggregate formation and clearance of abnormal proteins in neurodegenerative disorders

  垣塚 彰

  生体の科学, Nov. 2009

  
• Listeria monocytogenes ActA-mediated escape from autophagic recognition

  Yuko Yoshikawa; Michinaga Ogawa; Torsten Hain; Mitsutaka Yoshida; Makoto Fukumatsu; Minsoo Kim; Hitomi Mimuro; Ichiro Nakagawa; Toru Yanagawa; Tetsuro Ishii; Akira Kakizuka; Elizabeth Sztul; Trinad Chakraborty; Chihiro Sasakawa

  NATURE CELL BIOLOGY, Oct. 2009, Peer-reviewed

  
• An Inhibitor of a Deubiquitinating Enzyme Regulates Ubiquitin Homeostasis

  Yoko Kimura; Hideki Yashiroda; Tai Kudo; Sumiko Koitabashi; Shigeo Murata; Akira Kakizuka; Keiji Tanaka

  CELL, May 2009, Peer-reviewed

  
• p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation

  Chiho Mori-Konya; Naruyoshi Kato; Ryota Maeda; Kunihiko Yasuda; Naoki Higashimae; Masakatsu Noguchi; Masaaki Koike; Yoko Kimura; Hiroshi Ohizumi; Seiji Hori; Akira Kakizuka

  GENES TO CELLS, Apr. 2009, Peer-reviewed

  
• 神経変性疾患とVCP

  垣塚 彰

  Clinical Neuroscience 中外医学社 27:964-965, 2009

  
• Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor.

  Rei Nomura; Yoshikazu Suzuki; Akira Kakizuka; Hisato Jingami

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2008, Peer-reviewed

  
• Roles of VCP in human neurodegenerative disorders

  Akira Kakizuka

  BIOCHEMICAL SOCIETY TRANSACTIONS, Feb. 2008, Peer-reviewed

  
• Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates

  Taeko Kobayashi; Atsushi Manno; Akira Kakizuka

  GENES TO CELLS, Jul. 2007, Peer-reviewed

  
• [Protein modifications in neurodegenerative disorders].

  Kakizuka A; Koike M

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jun. 2007, Peer-reviewed

  
• 神経変性疾患に関わる蛋白質の種々の修飾

  垣塚 彰; 小池雅昭

  蛋白質・核酸・酵素 52:768-773, 2007

  
• [Neurodegenerative disorder and the nucleus].

  Kakizuka A

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Nov. 2006, Peer-reviewed

  
• In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia

  H Matsushita; PP Scaglioni; M Bhaumik; EM Rego; LF Cai; SM Majid; H Miyachi; A Kakizuka; WH Miller; PP Pandolfi

  JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2006, Peer-reviewed

  
• Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-x(L)

  AH Chou; TH Yeh; YL Kuo; YC Kao; MJ Jou; CY Hsu; Tsai, SR; A Kakizuka; HL Wang

  NEUROBIOLOGY OF DISEASE, Feb. 2006, Peer-reviewed

  
• Dominant-negative effect of mutant valosin-containing protein in aggresome formation

  MI Kitami; T Kitami; M Nagahama; M Tagaya; S Hori; A Kakizuka; Y Mizuno; N Hattori

  FEBS LETTERS, Jan. 2006, Peer-reviewed

  
• ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in walker a motif

  M Noguchi; T Takata; Y Kimura; A Manno; K Murakami; M Koike; H Ohizumi; S Hori; A Kakizuka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2005, Peer-reviewed

  
• Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha

  YA Wang; K Shen; Y Ishida; YL Wang; A Kakizuka; SC Brooks

  MOLECULAR CARCINOGENESIS, Dec. 2005, Peer-reviewed

  
• alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor

  T Shiraki; N Kamiya; S Shiki; TS Kodama; A Kakizuka; H Jingami

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2005, Peer-reviewed

  
• Retinoid signaling competence and RAR beta-mediated gene regulation in the developing mammalian telencephalon

  WL Liao; HF Wang; HC Tsai; P Chambon; M Wagner; AK Kakizuka; FC Liu

  DEVELOPMENTAL DYNAMICS, Apr. 2005, Peer-reviewed

  
• Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders

  S Ishigaki; N Hishikawa; J Niwa; S Iemura; T Natsume; S Hori; A Kakizuka; K Tanaka; G Sobue

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2004, Peer-reviewed

  
• A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration

  D Goti; SM Katzen; J Mez; N Kurtis; J Kiluk; L Ben-Haiem; NA Jenkins; NG Copeland; A Kakizuka; AH Sharp; CA Ross; PR Mouton; Colomer, V

  JOURNAL OF NEUROSCIENCE, Nov. 2004, Peer-reviewed

  
• Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RAR alpha chimeric gene

  A Sato; M Imaizumi; Y Hoshi; T Rikiishi; K Fujii; M Kizaki; H Kagechika; A Kakizuka; Y Hayashi; K Iinuma

  LEUKEMIA RESEARCH, Sep. 2004, Peer-reviewed

  
• The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions

  Y Kimura; S Koitabashi; A Kakizuka; T Fujita

  GENES TO CELLS, Aug. 2004, Peer-reviewed

  
• Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

  H Maeda; S Hori; H Ohizumi; T Segawa; Y Kakehi; O Ogawa; A Kakizuka

  CELL DEATH AND DIFFERENTIATION, Jul. 2004, Peer-reviewed

  
• [Neurodegenerative disorders as protein misfolding diseases and organelle diseases].

  Kakizuka A; Mori M

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, May 2004, Peer-reviewed

  
• [Therapeutic targets in polyglutamine diseases].

  Hori S; Kakizuka A

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, May 2004, Peer-reviewed

  
• Molecular clearance of ataxin-3 is regulated by a mammalian E4

  M Matsumoto; M Yada; S Hatakeyama; H Ishimoto; T Tanimura; S Tsuji; A Kakizuka; M Kitagawa; KI Nakayama

  EMBO JOURNAL, Feb. 2004, Peer-reviewed

  
• Polyglutamine diseases and molecular chaperones

  Y Kimura; A Kakizuka

  IUBMB LIFE, Jun. 2003, Peer-reviewed

  
• Vacuole-creating protein in neurodegenerative diseases in humans

  Y Mizuno; S Hori; A Kakizuka; K Okamoto

  NEUROSCIENCE LETTERS, Jun. 2003, Peer-reviewed

  
• Molecular analyses of Machado-Joseph disease

  T Kobayashi; A Kakizuka

  CYTOGENETIC AND GENOME RESEARCH, 2003, Peer-reviewed

  
• Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells

  T Kobayashi; K Tanaka; K Inoue; A Kakizuka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed

  
• A challenge for revealing common molecular mechanisms underlying neurodegenerative disorders

  Akira Kakizuka

  Clinical Neurology, 01 Nov. 2002, Peer-reviewed

  
• Circumvention of chaperone requirement for aggregate formation of a short polyglutamine tract by the co-expression of a long polyglutamine tract

  Y Kimura; S Koitabashi; A Kakizuka; T Fujita

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

  H Nishitoh; A Matsuzawa; K Tobiume; K Saegusa; K Takeda; K Inoue; S Hori; A Kakizuka; H Ichijo

  GENES & DEVELOPMENT, Jun. 2002, Peer-reviewed

  
• Unequal crossing-over in unique PABP2 mutations in Japanese patients - A possible cause of Oculopharyngeal muscular dystrophy

  M Nakamoto; S Nakano; S Kawashima; M Ihara; Y Nishimura; A Shinde; A Kakizuka

  ARCHIVES OF NEUROLOGY, Mar. 2002, Peer-reviewed

  
• Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration

  H Higashiyama; F Hirose; M Yamaguchi; YH Inoue; N Fujikake; A Matsukage; A Kakizuka

  CELL DEATH AND DIFFERENTIATION, Mar. 2002, Peer-reviewed

  
• 亜砒酸とL-Buthionine-SulfoximineによるH2O2スカベンジャーの阻害 癌選択的に細胞死を誘導する新規併用化学療法のアンドロゲン非依存性前立腺癌治療への試み

  前田 浩; 清川 岳彦; 筧 善行; 大泉 宏; 堀 清次; 垣塚 彰; 小川 修

  日本泌尿器科学会雑誌, Feb. 2002

  
• VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration

  M Hirabayashi; K Inoue; K Tanaka; K Nakadate; Y Ohsawa; Y Kamei; AH Popiel; A Sinohara; A Iwamatsu; Y Kimura; Y Uchiyama; S Hori; A Kakizuka

  CELL DEATH AND DIFFERENTIATION, Oct. 2001, Peer-reviewed

  
• Initial process of polyglutamine aggregate formation in vivo

  Y Kimura; S Koitabashi; A Kakizuka; T Fujita

  GENES TO CELLS, Oct. 2001, Peer-reviewed

  
• Isolation of neuronal cells with high processing activity for the Machado-Joseph disease protein

  Y Yamamoto; H Hasegawa; K Tanaka; A Kakizuka

  CELL DEATH AND DIFFERENTIATION, Aug. 2001, Peer-reviewed

  
• Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer

  H Maeda; S Hori; H Nishitoh; H Ichijo; O Ogawa; Y Kakehi; A Kakizuka

  CANCER RESEARCH, Jul. 2001, Peer-reviewed

  
• Rapid detection of candidate metastatic foci in the orthotopic inoculation model of androgen-sensitive prostate cancer cells introduced with green fluorescent protein

  H Maeda; T Segawa; T Kamoto; H Yoshida; A Kakizuka; O Ogawa; Y Kakehi

  PROSTATE, Dec. 2000, Peer-reviewed

  
• Approaches from genetical analyses on human diseases: neurodegenerative diseases

  A. Kakizuka

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Peer-reviewed

  
• Erratum: Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies (Genes to Cells 4:12)

  Yasuda S; Inoue K; Hirabayashi M; Higashiyama H; Yamamoto Y; Fuyushiro H; Komure O; Tanaka F; Sobue G; Tsuchiya K; Hamada K; Sasaki H; Takeda K; Ichijo H; Kakizuka A

  Genes to Cells, 2000, Peer-reviewed

  
• Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

  S Yasuda; K Inoue; M Hirabayashi; H Higashiyama; Y Yamamoto; H Fuyuhiro; O Komure; F Tanaka; G Sobue; K Tsuchiya; K Hamada; H Sasaki; K Takeda; H Ichijo; A Kakizuka

  GENES TO CELLS, Dec. 1999, Peer-reviewed

  
• Caspase-8 is required for cell death induced by expanded polyglutamine repeats

  Sanchez, I; CJ Xu; P Juo; A Kakizaka; J Blenis; JY Yuan

  NEURON, Mar. 1999, Peer-reviewed

  
• Recent progress in the research field on triplet repeat diseases

  Akira Kakizuka

  Clinical Neurology, Dec. 1998, Peer-reviewed

  
• Protein precipitation: a common etiology in neurodegenerative disorders?

  A Kakizuka

  TRENDS IN GENETICS, Oct. 1998, Peer-reviewed

  
• Mutations in the E-domain of RAR alpha portion of the PML/RAR alpha chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia

  M Imaizumi; H Suzuki; M Yoshinari; A Sato; T Saito; A Sugawara; S Tsuchiya; Y Hatae; T Fujimoto; A Kakizuka; T Konno; K Iinuma

  BLOOD, Jul. 1998, Peer-reviewed

  
• Fas and mutant estrogen receptor chimeric gene: A novel suicide vector for tamoxifen-inducible apoptosis

  H Kodaira; A Kume; Y Ogasawara; M Urabe; K Kitano; A Kakizuka; K Ozawa

  JAPANESE JOURNAL OF CANCER RESEARCH, Jul. 1998, Peer-reviewed

  
• Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts

  M Kokubun; A Kume; M Urabe; H Mano; M Okubo; R Kasukawa; A Kakizuka; K Ozawa

  GENE THERAPY, Jul. 1998, Peer-reviewed

  
• Prostate-specific amplification of expanded polyglutamine expression: A novel approach for cancer gene therapy

  T Segawa; H Takebayashi; Y Kakehi; O Yoshida; S Narumiya; A Kakizuka

  CANCER RESEARCH, Jun. 1998, Peer-reviewed

  
• Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

  CL Wellington; LM Ellerby; AS Hackam; RL Margolis; MA Trifiro; R Singaraja; K McCutcheon; GS Salvesen; SS Propp; M Bromm; KJ Rowland; TQ Zhang; D Rasper; S Roy; N Thornberry; L Pinsky; A Kakizuka; CA Ross; DW Nicholson; DE Bredesen; MR Hayden

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1998, Peer-reviewed

  
• Structure of the retinoic acid receptor and its functional analysis using a mutated receptor

  A. Kakizuka

  Nippon rinsho. Japanese journal of clinical medicine, 1998, Peer-reviewed

  
• A CAG/CTG expansion in the normal population

  M Nakamoto; H Takebayashi; Y Kawaguchi; S Narumiya; M Taniwaki; Y Nakamura; Y Ishikawa; Akiguchi, I; J Kimura; A Kakizuka

  NATURE GENETICS, Dec. 1997, Peer-reviewed

  
• Characterization of the mouse prostaglandin F receptor gene: a transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary

  K Hasumoto; Y Sugimoto; M Gotoh; E Segi; A Yamasaki; M Yamaguchi; H Honda; H Hirai; M Negishi; A Kaizuka; A Ichikawa

  GENES TO CELLS, Sep. 1997, Peer-reviewed

  
• Degenerative ataxias: Genetics, pathogenesis and animal models

  A Kakizuka

  CURRENT OPINION IN NEUROLOGY, Aug. 1997, Peer-reviewed

  
• Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines

  Y Kawaguchi; H Takebayashi; A Kakizuka; S Arii; M Kato; M Imamura

  CANCER LETTERS, Jun. 1997, Peer-reviewed

  
• p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

  N Watanabe; P Madaule; T Reid; T Ishizaki; G Watanabe; A Kakizuka; Y Saito; K Nakao; BM Jockusch; S Narumiya

  EMBO JOURNAL, Jun. 1997, Peer-reviewed

  
• Analyses of dominant mutations and their phenotypes: Unraveling of physiological functions of retinoid and identification of the responsible gene for Machado-Joseph disease

  A Kakizuka

  SEIKAGAKU, Feb. 1997, Peer-reviewed

  
• Degenerative ataxias : pathogenesis, genetics, and disease models

  垣塚 彰

  Current opinion in neurology,10/,285-290, 1997, Peer-reviewed

  
• Cloning, functional expression and tissue distribution of rabbit alpha(1d)-adrenoceptor

  F Suzuki; S Miyamoto; M Takita; M Oshita; Y Watanabe; A Kakizuka; S Narumiya; T Taniguchi; Muramatsu, I

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jan. 1997, Peer-reviewed

  
• Association of expression of mRNA encoding the PGF(2 alpha) receptor with luteal cell apoptosis in ovaries of pseudopregnant mice

  K Hasumoto; Y Sugimoto; A Yamasaki; K Morimoto; A Kakizuka; M Negishi; A Ichikawa

  JOURNAL OF REPRODUCTION AND FERTILITY, Jan. 1997, Peer-reviewed

  
• Use of transgenic mice to eliminate retinoic acid receptor function in specific tissues

  M Saitou; T Tanaka; A Kakizuka

  VITAMINS AND COENZYMES, PT L, 1997, Peer-reviewed

  
• Hormone-induced apoptosis by Fas-nuclear receptor fusion proteins: Novel biological tools for controlling apoptosis in vivo

  H Takebayashi; H Oida; K Fujisawa; M Yamaguchi; T Hikida; M Fukumoto; S Narumiya; A Kakizuka

  CANCER RESEARCH, Sep. 1996, Peer-reviewed

  
• Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

  H Ikeda; M Yamaguchi; S Sugai; Y Aze; S Narumiya; A Kakizuka

  NATURE GENETICS, Jun. 1996, Peer-reviewed

  
• Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

  H Ikeda; M Yamaguchi; S Sugai; Y Aze; S Narumiya; A Kakizuka

  NATURE GENETICS, Jun. 1996, Peer-reviewed

  
• Unravelling of physiological functions of retinoids using a dominant-negative retinoic acid receptor

  A Kakizuka; M Saitou

  JOURNAL OF BIOSCIENCES, May 1996, Peer-reviewed

  
• The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

  T Ishizaki; M Maekawa; K Fujisawa; K Okawa; A Iwamatsu; A Fujita; N Watanabe; Y Saito; A Kakizuka; N Morii; S Narumiya

  EMBO JOURNAL, Apr. 1996, Peer-reviewed

  
• Two thromboxane A(2) receptor isoforms in human platelets - Opposite coupling to adenylyl cyclase with different sensitivity to Arg(60) to Leu mutation

  T Hirata; F Ushikubi; A Kakizuka; M Okuma; S Narumiya

  JOURNAL OF CLINICAL INVESTIGATION, Feb. 1996, Peer-reviewed

  
• Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

  G Watanabe; Y Saito; P Madaule; T Ishizaki; K Fujisawa; N Morii; H Mukai; Y Ono; A Kakizuka; S Narumiya

  SCIENCE, Feb. 1996, Peer-reviewed

  
• Isolation of the gene responsible for Machado-Joseph disease

  A. Kakizuka

  Japanese Journal of Human Genetics, 1996, Peer-reviewed

  
• Is retinoic acid essential for the development?

  A. Kakizuka

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1996, Peer-reviewed

  
• Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2

  Minoru Okuma; Takako Hirata; Fumitaka Ushikubi; Akira Kakizuka; Shu Narumiya

  Polish Journal of Pharmacology, 1996, Peer-reviewed

  
• Gene hunting for Machado Joseph disease

  A. Kakizuka

  Brain and Nerve, 1996, Peer-reviewed

  
• ACTIVIN AND ITS RECEPTORS DURING GASTRULATION AND THE LATER PHASES OF MESODERM DEVELOPMENT IN THE CHICK-EMBRYO

  CD STERN; RT YU; A KAKIZUKA; CR KINTNER; LS MATHEWS; WW VALE; RM EVANS; K UMESONO

  DEVELOPMENTAL BIOLOGY, Nov. 1995, Peer-reviewed

  
• DEGRADATION OF C-FOS BY THE 26S PROTEASOME IS ACCELERATED BY C-JUN AND MULTIPLE PROTEIN-KINASES

  C TSURUMI; N ISHIDA; T TAMURA; A KAKIZUKA; E NISHIDA; E OKUMURA; T KISHIMOTO; M INAGAKI; K OKAZAKI; N SAGATA; A ICHIHARA; K TANAKA

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 1995, Peer-reviewed

  
• MOLECULAR-FEATURES OF THE CAG REPEATS AND CLINICAL MANIFESTATION OF MACHADO-JOSEPH DISEASE

  H MARUYAMA; S NAKAMURA; Z MATSUYAMA; T SAKAI; M DOYU; G SOBUE; M SETO; M TSUJIHATA; T OHI; T NISHIO; N SUNOHARA; R TAKAHASHI; M HAYASHI; NISHINO, I; T OHTAKE; T ODA; M NISHIMURA; T SAIDA; H MATSUMOTO; M BABA; Y KAWAGUCHI; A KAKIZUKA; H KAWAKAMI

  HUMAN MOLECULAR GENETICS, May 1995, Peer-reviewed

  
• INHIBITION OF SKIN DEVELOPMENT BY TARGETED EXPRESSION OF A DOMINANT-NEGATIVE RETINOLE ACID RECEPTOR

  M SAITOU; S SUGAI; T TANAKA; K SHIMOUCHI; E FUCHS; S NARUMIYA; A KAKIZUKA

  NATURE, Mar. 1995, Peer-reviewed

  
• Unique features of the CAG repeats in Machado–Joseph disease

  Hideshi Kawakami; Hirofumi Maruyama; Shigenobu Nakamura; Yoshiya Kawaguchi; Akira Kakizuka; Manabu Doyu; Gen Sobue

  Nature Genetics, 1995, Peer-reviewed

  
• CAG EXPANSIONS IN A NOVEL GENE FOR MACHADO-JOSEPH DISEASE AT CHROMOSOME-14Q32.1

  A KAKIZUKA; Y KAWAGUCHI; T OKAMOTO; S NARUMIYA

  JOURNAL OF NEUROCHEMISTRY, 1995, Peer-reviewed

  
• CAG EXPANSIONS IN A NOVEL GENE FOR MACHADO-JOSEPH DISEASE AT CHROMOSOME 14Q32.1

  Y KAWAGUCHI; T OKAMOTO; M TANIWAKI; M AIZAWA; M INOUE; S KATAYAMA; H KAWAKAMI; S NAKAMURA; M NISHIMURA; AKIGUCHI, I; J KIMURA; S NARUMIYA; A KAKIZUKA

  NATURE GENETICS, Nov. 1994, Peer-reviewed

  
• TRANSCRIPTIONAL REGULATION OF HUMAN TRANSGLUTAMINASE1 GENE BY SIGNALING SYSTEMS OF PROTEIN-KINASE-C, RAR/RXR AND JUN/FOS IN KERATINOCYTES

  K YAMADA; K YAMANISHI; A KAKIZUKA; Y KIBE; H DOI; H YASUNO

  BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, Oct. 1994, Peer-reviewed

  
• ARG(60) TO LEU MUTATION OF THE HUMAN THROMBOXANE A(2) RECEPTOR IN A DOMINANTLY INHERITED BLEEDING DISORDER

  T HIRATA; A KAKIZUKA; F USHIKUBI; FUSE, I; M OKUMA; S NARUMIYA

  JOURNAL OF CLINICAL INVESTIGATION, Oct. 1994, Peer-reviewed

  
• ALTERATION OF A SINGLE AMINO-ACID RESIDUE IN RETINOIC ACID RECEPTOR CAUSES DOMINANT-NEGATIVE PHENOTYPE

  M SAITOU; S NARUMIYA; A KAKIZUKA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1994, Peer-reviewed

  
• CDNA CLONING OF A MOUSE PROSTACYCLIN RECEPTOR - MULTIPLE SIGNALING PATHWAYS AND EXPRESSION IN THYMIC MEDULLA

  T NAMBA; H OIDA; Y SUGIMOTO; A KAKIZUKA; M NEGISHI; A ICHIKAWA; S NARUMIYA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1994, Peer-reviewed

  
• Cloning and expression of a cDNA for mouse prostaglandin F receptor

  Yukihiko Sugimoto; Ken-Yuh Hasumoto; Tsunehisa Namba; Atsushi Irie; Masato Katsuyama; Manabu Negishi; Akira Kakizuka; Shuh Narumiya; Atsushi Ichikawa

  Journal of Biological Chemistry, 14 Jan. 1994, Peer-reviewed

  
• A NOVEL MACROMOLECULAR STRUCTURE IS A TARGET OF THE PROMYELOCYTE-RETINOIC ACID RECEPTOR ONCOPROTEIN

  JA DYCK; GG MAUL; WH MILLER; JD CHEN; A KAKIZUKA; RM EVANS

  CELL, Jan. 1994, Peer-reviewed

  
• CHARACTERIZATION AND CHROMOSOMAL MAPPING OF THE HUMAN THROMBOXANE-A(2) RECEPTOR GENE

  RM NUSING; M HIRATA; A KAKIZUKA; T EKI; K OZAWA; S NARUMIYA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1993, Peer-reviewed

  
• ALTERNATIVE SPLICING OF C-TERMINAL TAIL OF PROSTAGLANDIN-E RECEPTOR SUBTYPE-EP3 DETERMINES G-PROTEIN SPECIFICITY

  T NAMBA; Y SUGIMOTO; M NEGISHI; A IRIE; F USHIKUBI; A KAKIZUKA; S ITO; A ICHIKAWA; S NARUMIYA

  NATURE, Sep. 1993, Peer-reviewed

  
• UNEXPECTED HETEROGENEITY OF PML/RAR-ALPHA FUSED MESSENGER-RNA DETECTED BY NESTED POLYMERASE CHAIN-REACTION IN ACUTE PROMYELOCYTIC LEUKEMIA

  A MATSUOKA; K MIYAMURA; N EMI; T TAHARA; M TANIMOTO; T NAOE; R OHNO; A KAKIZUKA; RM EVANS; H SAITO

  LEUKEMIA, Aug. 1993, Peer-reviewed

  
• RETINOID RECEPTORS

  DJ MANGELSDORF; SA KLIEWER; A KAKIZUKA; K UMESONO; RM EVANS

  RECENT PROGRESS IN HORMONE RESEARCH, VOL 48, 1993, Peer-reviewed

  
• Different C-terminal tails produced by alternative aplicing in isoforms of prostaglandin E receptor EP3 subtype determine G protein specificity. (共著)

  垣塚 彰

  Nature,365/,166, 1993, Peer-reviewed

  
• PML-RAR, A FUSION PROTEIN IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA

  A KAKIZUKA; RM EVANS

  CANCER CHEMOTHERAPY: CHALLENGES FOR THE FUTURE, VOL 8, 1993, Peer-reviewed

  
• HOT PAPERS - MOLECULAR-BIOLOGY - CHROMOSOMAL TRANSLOCATION T(15 17) IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA FUSES RAR-ALPHA WITH A NOVEL PUTATIVE TRANSCRIPTION FACTOR, PML BY KAKIZUKA,A., MILLER,W.H., UMESONO,K., WARRELL,R.P., ETAL

  A KAKIZUKA

  SCIENTIST, Oct. 1992, Peer-reviewed

  
• A MOUSE CDC25 HOMOLOG IS DIFFERENTIALLY AND DEVELOPMENTALLY EXPRESSED

  A KAKIZUKA; B SEBASTIAN; U BORGMEYER; HERMANSBORGMEYER, I; J BOLADO; T HUNTER; MF HOEKSTRA; RM EVANS

  GENES & DEVELOPMENT, Apr. 1992, Peer-reviewed

  
• I-KAPPA-B-GAMMA, A 70 KD PROTEIN IDENTICAL TO THE C-TERMINAL HALF OF P110 NF-KAPPA-B - A NEW MEMBER OF THE I-KAPPA-B FAMILY

  J INOUE; LD KERR; A KAKIZUKA; IM VERMA

  CELL, Mar. 1992, Peer-reviewed

  
• CHARACTERIZATION OF 3 RXR GENES THAT MEDIATE THE ACTION OF 9-CIS RETINOIC ACID

  DJ MANGELSDORF; U BORGMEYER; RA HEYMAN; JY ZHOU; ES ONG; AE ORO; A KAKIZUKA; RM EVANS

  GENES & DEVELOPMENT, Mar. 1992, Peer-reviewed

  
• CHROMOSOMAL TRANSLOCATION T(15-17) IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA FUSES RAR-ALPHA WITH A NOVEL PUTATIVE TRANSCRIPTION FACTOR, PML

  A KAKIZUKA; WH MILLER; K UMESONO; RP WARRELL; FRANKEL, SR; VVVS MURTY; E DMITROVSKY; RM EVANS

  CELL, Aug. 1991, Peer-reviewed

  
• EXAMINATION OF HTLV-I INTEGRATION IN THE SKIN-LESIONS OF VARIOUS TYPES OF ADULT T-CELL LEUKEMIA (ATL) - INDEPENDENCE OF CUTANEOUS-TYPE ATL CONFIRMED BY SOUTHERN BLOT ANALYSIS

  N DOSAKA; T TANAKA; Y MIYACHI; S IMAMURA; A KAKIZUKA

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Feb. 1991, Peer-reviewed

  
• Characterization of the lymphoproliferative diseases in the skin by DNA analysis

  N. Nakajima; T. Tanaka; Y. Miyachi; S. Imamura; A. Kakizuka

  Journal of Dermatology, 1991, Peer-reviewed

  
• Molecular characterization of mammalian tachykinin receptors and a possible epithelial potassium channel

  Shigetada Nakanishi; Hiroaki Ohkubo; Akira Kakizuka; Yoshifumi Yokota; Ryuichi Shigemoto; Yoshiki Sasai; Toru Takumi

  Recent Progress in Hormone Research, 1991, Peer-reviewed

  
• PROTEASOMES ARE ESSENTIAL FOR YEAST PROLIFERATION - CDNA CLONING AND GENE DISRUPTION OF 2 MAJOR SUBUNITS

  T FUJIWARA; K TANAKA; E ORINO; T YOSHIMURA; A KUMATORI; T TAMURA; CH CHUNG; T NAKAI; K YAMAGUCHI; S SHIN; A KAKIZUKA; S NAKANISHI; A ICHIHARA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1990, Peer-reviewed

  
• A SET OF U1 SNRNA-COMPLEMENTARY SEQUENCES INVOLVED IN GOVERNING ALTERNATIVE RNA SPLICING OF THE KININOGEN GENES

  A KAKIZUKA; T INGI; T MURAI; S NAKANISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1990, Peer-reviewed

  
• MOLECULAR-CLONING OF CDNA FOR PROTEASOMES FROM RAT-LIVER - PRIMARY STRUCTURE OF COMPONENT-C3 WITH A POSSIBLE TYROSINE PHOSPHORYLATION SITE

  K TANAKA; T FUJIWARA; A KUMATORI; S SHIN; T YOSHIMURA; A ICHIHARA; F TOKUNAGA; R ARUGA; S IWANAGA; A KAKIZUKA; S NAKANISHI

  BIOCHEMISTRY, Apr. 1990, Peer-reviewed

  
• MOLECULAR CHARACTERIZATION OF A FUNCTIONAL CDNA FOR RAT SUBSTANCE-P RECEPTOR

  Y YOKOTA; Y SASAI; K TANAKA; T FUJIWARA; K TSUCHIDA; R SHIGEMOTO; A KAKIZUKA; H OHKUBO; S NAKANISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1989, Peer-reviewed

  
• MOLECULAR-CLONING OF CDNA FOR PROTEASOMES (MULTICATALYTIC PROTEINASE COMPLEXES) FROM RAT-LIVER - PRIMARY STRUCTURE OF THE LARGEST COMPONENT (C2)

  T FUJIWARA; K TANAKA; A KUMATORI; S SHIN; T YOSHIMURA; A ICHIHARA; F TOKUNAGA; R ARUGA; S IWANAGA; A KAKIZUKA; S NAKANISHI

  BIOCHEMISTRY, Sep. 1989, Peer-reviewed

  
• MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF HUMAN GENOMIC DNA ENCODING A NOVEL MEMBRANE-PROTEIN WHICH EXHIBITS A SLOWLY ACTIVATING POTASSIUM CHANNEL ACTIVITY

  T MURAI; A KAKIZUKA; T TAKUMI; H OHKUBO; S NAKANISHI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 1989, Peer-reviewed

  
• Control of kininogen gene expression.

  S. Nakanishi; N. Kitamura; H. Ohkubo; A. Kakizuka; R. Kageyama; Y. Masu; K. Nakayama

  Advances in experimental medicine and biology, 1989, Peer-reviewed

  
• LOCALIZATION OF DNA-SEQUENCES GOVERNING ALTERNATIVE MESSENGER-RNA PRODUCTION OF RAT KININOGEN GENES

  A KAKIZUKA; N KITAMURA; S NAKANISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1988, Peer-reviewed

  
• OXIDATIVE AND REDUCTIVE REACTIONS OF SULFHEMOGLOBIN WITH VARIOUS REAGENTS CORRELATED WITH CHANGES IN QUATERNARY STRUCTURE OF THE PROTEIN

  A TOMODA; A KAKIZUKA; Y YONEYAMA

  BIOCHEMICAL JOURNAL, 1984, Peer-reviewed

  

Misc.

• 共有結合性リガンドの開発を指向したPPARγ活性化機構の解析

  大寺杏奈; 宮前友策; 吉田光多郎; 秋田徹; 前嶋一宏; 垣塚彰; 増田誠司; 神戸大朋; 永尾雅哉

  日本生化学会大会(Web), 2014

  
• 【骨形成の新機能を探る-Reverse Geneticsで解明する骨代謝】 ドミナントネガティブ型レチノイン酸受容体によって誘導された骨格異常

  垣塚 彰; 山口 正洋

  実験医学, Feb. 1998

  
• ポリグルタミン病における創薬標的 (細胞における 蛋白質の一生--生成・成熟・輸送・管理・分解・病態) -- (病態・フォールディング病)

  堀 清次; 垣塚 彰

  蛋白質核酸酵素, May 2004

  
• Triggering neuronal cell death by the in situ activation of SEK1 on nuclear polyglutamine aggregation

  YASUDA Shingo; INOUE Kiyoshi; HIRABAYASHI Miho; KAKIZUKA Akira

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• 孤発型パーキンソン病(PD)におけるValosin containing protein(VCP)の検討(続報)(平成15年度順天堂大学老人性疾患病態・治療研究センター研究発表会抄録)

  飯島 真喜子; 北見 聡章; 服部 信孝; 水野 美邦; 垣塚 彰

  順天堂医学, 22 Dec. 2004

  
• 孤発型パーキンソン病(PD)におけるValosin containing protein(VCP)の検討(続報)(平成16年度順天堂大学老人性疾患病態・治療研究センター研究発表会抄録)

  飯島 真喜子; 北見 聡章; 服部 信孝; 水野 美邦; 垣塚 彰

  順天堂医学, 30 Jun. 2005

  
• MPTPパーキンソン病モデルにおけるATP制御薬の発症緩和効果

  中野将希; 今村博臣; 笹岡紀男; 山本正道; 上村紀仁; 首藤敏之; 渕上智弘; 高橋良輔; 垣塚彰

  日本生体エネルギー研究会討論会講演要旨集, 05 Dec. 2017

  
• Imaging of intracellular ATP level revealed pannexin1-mediated programmed ATP decrease in apoptosis

  H. Imamura; S. Sakamoto; T. Yoshida; A. Kakizuka

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Jul. 2017

  
• ATP制御薬による細胞内ATP維持はMPTPパーキンソン病モデルにおいて発症を緩和する

  中野将希; 今村博臣; 笹岡紀男; 山本正道; 上村紀仁; 首藤敏之; 首藤敏之; 渕上智弘; 高橋良輔; 垣塚彰

  日本生化学会大会(Web), 2017

  
• VCPモジュレータを用いた難治眼疾患に対する新規治療法開発

  池田 華子; 垣塚 彰; 吉村 長久

  臨床薬理の進歩, Jun. 2016

  
• 網膜変性治療薬としての分岐鎖アミノ酸の効果の検討

  長谷川 智子; 池田 華子; 村岡 勇貴; 岩井 祥子; 垣塚 彰; 吉村 長久

  眼科臨床紀要, Jun. 2016

  
• VCPモジュレータによる眼難治疾患の新規神経保護治療

  池田 華子; 中野 紀子; 村岡 勇貴; 長谷川 智子; 畑 匡侑; 飯田 悠人; 岩井 祥子; 垣塚 彰; 吉村 長久

  眼科臨床紀要, Jun. 2016

  
• ピルビン酸キナーゼとピルビン酸デヒドロゲナーゼ複合体によるアセチルCoAの地産地消モデル

  松田俊; 足立淳; 井原賢; 田沼延公; 島礼; 垣塚彰; 井倉正枝; 井倉毅; 松田知成

  日本生化学会大会(Web), Dec. 2015

  
• リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製

  宮前友策; 大寺杏奈; 吉田光多郎; 前嶋一宏; 秋田徹; 垣塚彰; 入江一浩; 増田誠司; 神戸大朋; 永尾雅哉

  日本ケミカルバイオロジー学会第10回年会, Jun. 2015, Peer-reviewed

  
• 一細胞計測で見えてきたバクテリア細胞内ATP濃度の多様性

  柳沼秀幸; 柳沼秀幸; 柳沼秀幸; 河合信之輔; 河合信之輔; 田端和仁; 冨山佳祐; 垣塚彰; 小松崎民樹; 岡田康志; 野地博行; 野地博行; 今村博臣; 今村博臣

  日本細胞生物学会大会要旨集, Jun. 2015

  
• リガンド結合ポケットの特性に基づく新規共有結合性PPARγアゴニストの創製

  宮前友策; 大寺杏奈; 吉田光多郎; 秋田徹; 前嶋一宏; 垣塚彰; 入江一浩; 増田誠司; 神戸大朋; 永尾雅哉

  日本農芸化学会2015年度大会, Mar. 2015

  
• Protective effect of B101, a mixture of nutrients, in a retinal degeneration mouse model

  Hasegawa T; Hanako O Ikeda; Ohhashi H; Hata M; Muraoka Y; Kakizuka A; Yoshimura N

  Asia ARVO 2015, Feb. 2015, Peer-reviewed

  
• 定量的ATPイメージングから明らかになった集団内における単一大腸菌細胞内ATP濃度の多様性

  柳沼秀幸; 河合信之輔; 田端和仁; 冨山佳祐; 垣塚彰; 小松崎民樹; 野地博行; 今村博臣

  日本生体エネルギー研究会討論会講演要旨集, 11 Dec. 2014

  
• 細胞外ATPダイナミクスの解明に向けた蛍光ATPバイオセンサーQUEENの反応高速化と光安定化

  岩切竜太; 垣塚彰; 今村博臣

  日本生体エネルギー研究会第40回討論会（ポスター）, Dec. 2014, Peer-reviewed

  
• ATP制御による加齢関連疾患克服への挑戦

  垣塚 彰

  日本抗加齢医学会, Dec. 2014, Invited

  
• Cooperative activation of PPARγ by combination of irreversible antagonist and partial agonists: implication for novel activation mechanism based on covalent modification

  Yusaku Miyamae; Anna Ohtera; Kotaro Yoshida; Tohru Akita; Kazuhiro Maejima; Akira Kakizuka; Kazuhiro Irie; Seiji Masuda; Taiho Kambe; Masaya Nagao

  International Chemical Biology Society 3rd annual meeting, Nov. 2014, Peer-reviewed

  
• 網膜虚血再灌流ラットモデルにおけるvalosin-containing protein modifierの神経保護効果の検討

  畑匡侑; 池田華子; 飯田悠人; 吉川宗光; 長谷川智子; 村岡勇貴; 垣塚彰; 吉村長久

  第53回日本網膜硝子体学会総会, Nov. 2014, Peer-reviewed

  
• 共有結合性リガンドの開発を目指した新規PPARγ活性化機構の解明

  宮前友策; 大寺杏奈; 吉田光多郎; 秋田徹; 前嶋一宏; 垣塚彰; 増田誠司; 神戸大朋; 永尾雅哉

  第56回天然有機化合物討論会, Oct. 2014, Peer-reviewed

  
• 定量ATPイメージングによる単一細胞内ATP濃度の多様性の測定

  柳沼秀幸; 河合信之輔; 田端和仁; 冨山佳祐; 垣塚彰; 小松崎民樹; 岡田康志; 野地博行; 今村博臣

  第52回日本生物物理学会年会（口頭）, Sep. 2014, Peer-reviewed

  
• VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders.

  Akira Kakizuka

  7th Asian Aging Core for Longevity conference in Jeju, Sep. 2014, Peer-reviewed, Invited

  
• ATP制御による難治性疾患の新規治療戦略

  垣塚 彰

  第23回日本Cell Death学会学術集会, Jul. 2014, Peer-reviewed, Invited

  
• Neuroprotective effects of a VCP modulator on rat models of ischemia and reperfusion-induced retinal degeneration.

  Hata M; Ikeda-Ohhashi H; Hasegawa T; Nakano N; Muraoka Y; Kakizuka A; Yoshimura N

  ARVO2014, May 2014, Peer-reviewed

  
• Neuroprotective effect of a valosin-containing-protein ATPase inhibitor on late-stage retinal degeneration in a mouse model.

  Hasegawa T; Hanako O. Ikeda-Ohhashi H; Muraoka Y; KakizukaA; Yoshimura N

  World Ophthalmology Congress, Apr. 2014, Peer-reviewed

  
• PPARγアンタゴニスト変換活性物質による脂肪蓄積抑制機構の解析

  大寺杏奈; 宮前友策; 大泉宏; 垣塚彰; 増田誠司; 神戸大朋; 永尾雅哉

  日本農芸化学会2014年度大会, Mar. 2014

  
• 2SAP-04 Heterogeneity in ATP Concentrations in a Single Bacterial Cell Population Revealed by Quantitative Single-cell Imaging(Scenario of functions from minority and number fluctuations,Symposium,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Yaginuma Hideyuki; Kawai Shinnosuke; Tabata Kazuhito; Tomiyama Keisuke; Kakizuka Akira; Komatsuzaki Tamiki; Okada Yasushi; Noji Hiroyuki; Imamura Hiromi

  Seibutsu Butsuri, 2014

  
• Novel VCP modulators for the treatment of incurable eye diseases

  Akira Kakizuka

  BioJapan 2013, Oct. 2013, Peer-reviewed, Invited

  
• 蛍光ATPバイオセンサーを用いたインスリン分泌細胞内ATPのダイナミクスの計測

  田中喬; 長嶋一昭; 稲垣暢也; 野地博行; 垣塚彰; 今村博臣

  第86回日本生化学会大会（ポスター）, Sep. 2013, Peer-reviewed

  
• Novel VCP modulators mitigate major pathologies in mouse models of glaucoma and retinitis pigmentosa by their neuroprotective effects.

  Akira Kakizuka

  EMBO workshop “AAA+ proteins, Sep. 2013, Peer-reviewed, Invited

  
• 新規創薬標的としての細胞内主要ATPase、VCP

  垣塚 彰

  第86回日本生化学会大会, Sep. 2013, Peer-reviewed, Invited

  
• 新規神経保護創薬標的としての細胞内主要ATPase、VCP

  垣塚 彰

  第22回日本Cell Death学会学術集会, Jul. 2013, Peer-reviewed, Invited

  
• Imaging of intracellular ATP dynamics in single apoptotic cells.

  Shu-ichiro Sakamoto; Akira Kakizuka; Hiromi Imamura

  The 11th International Student Seminar, 06 Mar. 2013, Peer-reviewed

  
• Regulation of autophagosome formation by Golgi dyanamics via CDC2-p37/p47/VCP axis

  Yuko Ito; Masaaki Koike; Akira Kakizuka

  The 11th International Student Seminar（ポスター発表）, 05 Mar. 2013, Peer-reviewed

  
• VCP阻害剤による網膜神経保護効果のメカニズム

  IKEDA HANAKO; NAKANO NORIKO; MURAOKA YUKI; HASEGAWA TOMOKO; KAKIZUKA AKIRA; YOSHIMURA NAGAHISA

  日本眼科学会雑誌, 04 Mar. 2013

  
• バクテリア細胞内ATP濃度の一細胞計測

  柳沼秀幸; 柳沼秀幸; 河合信之輔; 田端和仁; 田端和仁; 冨山佳祐; 垣塚彰; 小松崎民樹; 今村博臣; 野地博行; 野地博行

  日本生化学会大会(Web), 2013

  
• アルツハイマー病予防薬の探索と薬理学的評価

  SASAOKA NORIO; SAKAMOTO MEGUMI; KANEMORI SHOKO; TSUKANO CHIHIRO; TAKEMOTO YOSHIJI; KAKIZUKA AKIRA

  日本Cell Death学会学術集会プログラム抄録集, 2013, Peer-reviewed

  
• アポトーシスにおける細胞内ATPの挙動の解析

  坂本修一朗; 野地博行; 垣塚彰; 今村博臣

  日本生体エネルギー研究会（ポスター発表）, 22 Dec. 2012, Peer-reviewed

  
• 蛍光ATPバイオセンサーを用いたインスリン分泌細胞内ATPのダイナミクスの計測

  田中喬; 長嶋一昭; 稲垣暢也; 野地博行; 垣塚彰; 今村博臣

  日本生体エネルギー研究会（ポスター発表）, 22 Dec. 2012, Peer-reviewed

  
• Fluorescent ATP biosensor optimized for imaging of cells from non-vertebrate model organisms

  Hiromi Imamura; Taiichi Tsuyama; Tadashi Uemura; Akira Kakizuka

  International Symposia "New Frontiers of Metabolism Research in Biomedical Sciences", 28 Sep. 2012, Peer-reviewed

  
• Genetically-encoded ATP biosensor for low temperatures

  Hiromi Imamura; Taiichi Tsuyama; Jun-ichi Kishikawa; Hiroyuki Noji; Akira Kakizuka; Ken Yokoyama; Tadashi Uemura

  European Bioenergetic Conference 2012（ポスター発表）, 19 Sep. 2012, Peer-reviewed

  
• Neuroprotective effects of VCP inhibitors on DBA/2J mice, a mouse model of glaucoma

  Hanako Ikeda; Noriko Nakano; Yuki Muraoka; Masanori Hangai; Akira Kakizuka; Nagahisa Yoshimura

  第23回日本緑内障学会, Sep. 2012, Peer-reviewed

  
• 緑内障モデルマウスにおけるVCP阻害剤による神経保護効果の検討

  池田華子; 中野紀子; 村岡勇貴; 吉村長久; 垣塚彰

  第７回日本ケミカルバイオロジー学会年会, 08 Jun. 2012, Peer-reviewed

  
• アルツハイマー病予防薬の探索と薬理学的効果

  笹岡紀男; 坂本めぐみ; 兼森祥子; 大泉宏; 垣塚彰

  第７回日本ケミカルバイオロジー学会年会, 08 Jun. 2012, Peer-reviewed

  
• VCP阻害剤による網膜色素変性モデルマウスにおける神経保護効果の検討

  池田華子; 中野紀子; 村岡勇貴; 板谷正紀; 垣塚彰; 吉村長久

  第116回日本眼科学会総会, 05 Apr. 2012, Peer-reviewed

  
• Simultaneous ATP and Ca2+ imaging of a single insulin-secreting islet cell.

  Takashi Tanaka; Kazuaki Nagashima; Nobuya Inagaki; Hiroyuki Noji; Akira Kakizuka; Hiromi Imamura

  The 10th International Student Seminar, 05 Mar. 2012, Peer-reviewed

  
• Identification of plant extracts with anti-Alzheimer’s disease activities.

  Norio Sasaoka; Megumi Sakamoto; Shoko Kanemori; Akira Kakizuka

  The 10th NTU-Japan International mini- symposium on Molecular and Cell biology & promotion of Academic Exchange and Collaborations for NTU-Japan, 08 Jan. 2012, Peer-reviewed

  
• VCP阻害剤によるDBA/2J緑内障モデルマウスにおける神経保護効果の検討

  IKEDA HANAKO; NAKANO NORIKO; MURAOKA YUKI; HANGAI MASANORI; KAKIZUKA AKIRA; YOSHIMURA NAGAHISA

  日本緑内障学会抄録集, 2012

  
• Pannexin 1は細胞内ATPレベルを制御することでアポトーシスの進行に重要な役割を果たす

  坂本修一朗; 野地博行; 垣塚彰; 今村博臣

  第37回日本生体エネルギー研究会シンポジウム（ポスター発表）, 21 Dec. 2011, Peer-reviewed

  
• ATPバイオセンサー(GO-ATeam)を用いた膵島β細胞のライブイメージング

  田中喬; 長嶋一昭; 稲垣暢也; 野地博行; 垣塚彰; 今村博臣

  第７回日本ケミカルバイオロジー学会年会（ポスター発表）, 21 Dec. 2011, Peer-reviewed

  
• Roles of ADAM10/kuzbanian in vasculogenesis of \nzebrafish.

  Tomosawa Anna; Atsuo Iida; Akira Kakizuka; Atsuko Sehara

  第34 回日本分子生物学会年会（2011.12.13 神奈川）, 13 Dec. 2011, Peer-reviewed

  
• Development for novel drugs for Alzheimer disease and glaucoma.

  Akira Kakizuka

  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会（ポスター発表）, 05 Oct. 2011, Peer-reviewed

  
• 飢餓条件下におけるVCPタンパク質の機能解析

  小池雅昭; 今村博臣; 垣塚彰

  第84回日本生化学会大会, 24 Sep. 2011, Peer-reviewed

  
• ポリグルタミン発現に伴うリノール酸含有リン脂質の低下

  福士順平; 一戸勇弦; 加藤悠; 垣塚彰

  第84回日本生化学会大会, 23 Sep. 2011, Peer-reviewed

  
• 今村博臣、中野雅裕、永井健治、野地博行、垣塚彰

  ミトコンドリアATP濃度は細胞質AT; 濃度とは半独立に制御されている

  第84回日本生化学会大会, 22 Sep. 2011, Peer-reviewed

  
• Involvement of MAGl1 and c-fos in schizophrenia like behavioral abnormality.

  Sachi Tsujikawa; Keizo Takao; Tsuyoshi Miyakawa; Haruaki Ninomiya; Tomoh Masaki; Akira Kakizuka

  第84回日本生化学会大会（22日口頭、23日ポスター発表）, Sep. 2011, Peer-reviewed

  
• HRA、OCT 同時撮影によるGLAST 欠損マウス網膜神経節細胞障害の経時変化

  中野紀子; 池田華子; 村岡勇貴; 板谷正紀; 垣塚彰; 吉村長久

  第115回日本眼科学会総会, 13 May 2011, Peer-reviewed

  
• Deficiency of sensory motor gating in MAGI-1 knockout mice

  Sachi Tsujikawa; Keizo Takao; Kazuo Nakanishi; Tsuyoshi Miyakawa; Akira Kakizuka; Haruaki Ninomiya; Tomoh Masaki; Hiroshi Hosokawa

  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会, 28 Mar. 2011, Peer-reviewed

  
• MAGI-1 modulates anxiety-like behavior in mice

  Sachi Tsujikawa; Yukio Taniguchi; Keizo Takao; Tsuyoshi Miyakawa; Shingo Maegawa; Shigeo Kobayashi; Haruaki Ninomiya; Tomoh Masaki; Akira Kakizuka; Hiroshi Hosokawa

  BMB2010, 07 Dec. 2010, Peer-reviewed

  
• キチン加水分解物より見出したオートファジー誘導物質

  芦田久; 新谷知也; 山崎文義; 加藤紀彦; 梅川碧里; 又平芳春; 垣塚彰; 戸谷一英; 山本憲二

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• アミノ糖によるオートファジー誘導の解析

  新谷知也; 山崎文義; 加藤紀彦; 梅川碧里; 又平芳春; 垣塚 彰; 戸谷一英; 山本憲二; 芦田 久

  日本農芸化学会関西支部第463回 講演会, 06 Feb. 2010, Peer-reviewed

  
• 異常タンパク質の蓄積によるVCPの翻訳後修飾とその機能

  小池雅昭

  第9回細胞死研究会, 19 Jan. 2010, Peer-reviewed

  
• ポリグルタミン発現に伴うリン脂質組成の変化

  福士順平

  第9回細胞死研究会, 19 Jan. 2010, Peer-reviewed

  
• MAGI‐1は不安様行動を調節する

  辻川幸; 谷口幸雄; 高雄啓三; 宮川剛; 前川真吾; 小林茂夫; 二宮治明; 眞崎知生; 垣塚彰; 細川浩

  生化学, 2010

  
• A comprehensive study \non expression patterns of zebrafish ADAM genes（ゼブラフィッシュADAM 遺伝子の包括的発現解析），

  Kazuya Sakaguchi; Tomomi Sato; Atsuo Iida; Naoki Irie; Akira Kakizuka; Atsuko Sehara

  ），43 rd anual Meeting for the Japanese Society of Developmentai Biokigists Jointly Sponsored by the Asia-Pacific Developmental Biology Network（第43 回日本発生生物学会年会）（2010.6.21 京都）, 2010, Peer-reviewed

  
• Meltrinβ（ADAM19）の心臓発生における役割（Rolesof Meltrin-beta （ADAM19）in heart development）

  荒井宏行; 佐藤文規; 垣塚彰; 瀬原淳子

  BMB2010（第33 回日本分子生物学会年会，第83 回日本生化学会大会 合同大会）（2010.12.8．兵庫）, 2010, Peer-reviewed

  
• ショウジョウバエRNAi系統を用いた新規ポリグルタミン病関連遺伝子のスクリーニング ：Screening of genes associating with polyglutamine diseases by drosophila melanogaster RNAi line

  一戸勇弦; 福士順平

  第82回日本生化学会大会, 24 Oct. 2009, Peer-reviewed

  
• IBMPFD・神経変性疾患の発症機構におけるVCP/p97とコファクターの役割：Involvement of VCP/p97 and co-factors in the pathogenesis of IBMPFD and neurodegenerative diseases

  萬野 篤; 野口昌克; 福士順平; 本橋康弘; 村上克洋; 東前直樹; 垣塚 彰

  第82回日本生化学会大会, 24 Oct. 2009, Peer-reviewed

  
• ポリグルタミン発現に伴うリン脂質組成の変化：Alteration of phospholipid composition associated with polyglutamine expression

  福士順平; 一戸勇弦; 佐上 聖; 垣塚 彰

  第82回日本生化学会大会, 24 Oct. 2009, Peer-reviewed

  
• 神経変性疾患に関わるVCPの翻訳後修飾とその機能：Modifications of VCP via Abnormal Protein Accumulation lead to Neuronal Cell Atrophy and Neurodegeneration

  小池雅昭; 一戸勇弦; 福士順平; 佐々木千代美; 垣塚 彰

  第82回日本生化学会大会, 24 Oct. 2009, Peer-reviewed

  
• 細胞周期におけるVCP/p97のリン酸化の役割の解析：Roles of VCP phosphorylation in cell cycle progression

  加藤成芳; 村上克洋; 紺谷千穂; 堀 清次; 垣塚 彰

  第82回日本生化学会大会, 23 Oct. 2009, Peer-reviewed

  
• 酵母のGPl10温度感受性変異株で見られる出芽阻害とDNA過剰複製 ：Budding defect and DNA over-replication in a yeast GPl10 temperature-sensitive mutant

  大沼洋平; 高田尚寛; 安田邦彦; 垣塚 彰

  第82回日本生化学会大会, 23 Oct. 2009, Peer-reviewed

  
• p97/VCPのATPase活性に作用する新規翻訳後修飾の同定：Identification of novel post-translational modifications which affect the ATPase activity of p97/VCP

  紺谷千穂; 加藤成芳; 前田良太; 小池雅昭; 安田邦彦; 野口昌克; 東前直樹; 木村洋子; 大泉 宏; 堀 清次; 垣塚 彰

  第82回日本生化学会大会, 22 Oct. 2009, Peer-reviewed

  
• ヒト子宮頸癌及び食道癌におけるVCP co-factor p47の発現上昇による浸潤能の獲得：Overexpression of p47, a VCP co-factor, in potential acquisition of invasion activities in human esophageal and cervical cancer

  一戸勇弦; 東前直樹; 大泉 宏; 垣塚 彰

  BMB2008, 11 Nov. 2008, Peer-reviewed

  
• 小胞体ストレスに対する新規応答機構：Inhibition of rRNA synthesis in response to ER stress.

  岡本暁彦; 安田邦彦; 垣塚 彰

  BMB2008, 11 Nov. 2008, Peer-reviewed

  
• VCPはペルオキシソームマトリックスタンパク質の輸送と分解に関与する：VCP is involved in peroxisomal matrix protein import and degradation.

  村上克洋; 垣塚 彰

  BMB2008, 11 Nov. 2008, Peer-reviewed

  
• Analysis of the epitope of an ER-residing VCP.

  Mariko Hamaguchi; Atsushi Manno; Akira Kkaizuka

  The 6th international student Seminar, 05 Mar. 2008, Peer-reviewed

  
• Involvement of VCP/p97 and co-factors in the formation of abnormal protein aggregates.

  Atsushi Manno; Masakatsu Noguchi; Junpei Fukushi; Yasuhiro Motohashi; Katsuhiro Murakami; Akira Kakizuka

  The 6th international student Seminar, 05 Mar. 2008, Peer-reviewed

  
• Modificaions of VCP via abnormal protein accumulation lead to neuronal cell atrophy and neurodegeneration.

  Masaaki Koike; Naoki Higashimae; Masahiko Fujishiro; Junpei Fukushi; Akira Kkaizuka

  7th international conference on AAA proteins, 09 Sep. 2007, Peer-reviewed

  
• 凝集体形成におけるVCPの役割

  萬野 篤

  「魅力ある大学院教育」イニシアティブ 「生命科学キャリアディベロップメント」 学術集会 生体応答システムとしての細胞死, 05 Feb. 2007, Peer-reviewed

  
• Dominant-negative effect of mutant valosin-containing protein in aggresome formation

  M. Kitami; T. Kitami; M. Nagahama; M. Tagaya; S. Hori; A. Kakizuka; Y. Mizuno; N. Hattori

  MOVEMENT DISORDERS, 2006

  
• 凝集タンパク質の分解過程におけるVCP/p97 の関与

  小林妙子; 萬野篤; 垣塚彰

  第78 回日本生化学会大会、神戸、2005., 2005, Peer-reviewed

  
• Examination of valosin containing protein (VCP) in Parkinson's disease (PD)

  M Iijima; T Kitami; S Hori; A Kakizuka; N Hattori; Y Mizuno

  MOVEMENT DISORDERS, 2004

  
• PPAR gamma coactivator 1 beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

  Y Kamei; H Ohizumi; Y Fujitani; T Nemoto; T Tanaka; N Takahashi; T Kawada; M Miyoshi; O Ezaki; A Kakizuka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2003, Peer-reviewed

  
• パーキンソン病(PD)におけるValosin containing protein(VCP)の検討(平成14年度順天堂大学 老人性疾患病態・治療研究センター研究発表会)

  飯島 真喜子; 高梨 雅史; 北見 聡章; 服部 信孝; 水野 美邦; 柴 佳保理; 堀 清次; 垣塚 彰

  順天堂医学, 30 Sep. 2003

  
• Impaired responsiveness to all-trans retinoic acid in cellular or molecular level of UF-1, a human acute promyelocytic leukemia cell line established from a patient who acquired ATRA-resistance

  M Imaizumi; A Sato; Y Hoshi; K Fujii; T Rikiishi; S Chikaoka; A Kakizuka; K Iinuma; Y Hayashi

  EXPERIMENTAL HEMATOLOGY, Jun. 2002

  
• Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells

  M Yamaguchi; M Nakamoto; H Honda; T Nakagawa; H Fujita; T Nakamura; H Hirai; S Narumiya; A Kakizuka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 1998, Peer-reviewed

  
• Tissue-specific amplification of the expression: A novel approach for cancer gene therapy.

  T Segawa; Y Kakehi; O Yoshida; S Narumiya; A Kakizuka

  JOURNAL OF UROLOGY, May 1998

  
• ポリグルタミンによる小脳変性マウスの作製

  山口 正洋; 池田 華子; 須貝 智司; 阿瀬 善也; 宮成 周; 垣塚 彰

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• 遺伝性神経変性疾患にみられる異常に伸長したポリグルタミンは培養細胞にアポトーシスによる細胞死を誘導する

  池田 華子; 山口 正洋; 成宮 周; 垣塚 彰

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Transgenic expression of PML/RAR alpha impairs myelopoiesis

  E Early; MAS Moore; A Kakizuka; K NasonBurchenal; P Martin; RM Evans; E Dmitrovsky

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 1996, Peer-reviewed

  
• Apoptosis-mediated regulation of granulocyte colony-stimulating factor production by genetically modified fibroblasts.

  M Kokubun; Y Ogasawara; M Urabe; K Ito; H Mano; A Kakizuka; K Ozawa

  BLOOD, Nov. 1995

  
• IDENTIFICATION OF 2 ISOFORMS OF HUMAN THROMBOXANE A2 RECEPTOR IN PLATELETS

  T HIRATA; A KAKIZUKA; F USHIKUBI; S NARUMIYA; M OKUMA

  THROMBOSIS AND HAEMOSTASIS, Jun. 1995

  
• DOMINANT-NEGATIVE RETINOIC ACID RECEPTOR (RAR) TRANSGENIC MICE REVEALED A DIRECT EVIDENCE FOR THE FUNCTION OF RAR IN THE DEVELOPMENT OF FETUS SKIN

  T TANAKA; S SUGAI; K SHIMOUCHI; M SAITO; A KAKIZUKA; S NARUMIYA; E FUCHS; S IMAMURA

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1995

  
• THE RELATIONSHIP BETWEEN TRINUCLEOTIDE REPEAT (CAG) LENGTH AND CLINICAL-FEATURE IN MACHADO-JOSEPH-DISEASE

  H KAWAKAMI; H MARUYAMA; Z MATSUYAMA; Y KAWAGUCHI; A KAKIZUKA; S NAKAMURA; T SAKAI; M DOYU; G SOBUE; M SETO; M TSUJIHATA; T OHI; K NISHIO; R TAKAHASHI; M HAYASHI; NISHINO, I; T OOTAKE; T ODA; K NISHIMURA; T SAIDA; S CHIBA; M BABA

  JOURNAL OF CELLULAR BIOCHEMISTRY, Apr. 1995

  
• CAG EXPANSIONS IN A NOVEL GENE FROM MACHADO-JOSEPH-DISEASE AT HUMAN CHROMOSOME-14Q32.1

  A KAKIZUKA; Y KAWAGUCHI; T OKAMOTO; S NARUMIYA

  JOURNAL OF CELLULAR BIOCHEMISTRY, Apr. 1995

  
• Development of Hormone-Induced Apoptosis and Its Application to Cancer Therapy.

  HIKIDA TAKATOSHI; TAKEBAYASHI HIROHIDE; FUKUMOTO MANABU; NARUMIYA SHU; KAKIZUKA AKIRA

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1994

  
• MOLECULAR CHARACTERIZATION OF A MOUSE PROSTAGLANDIN-D RECEPTOR AND FUNCTIONAL EXPRESSION OF THE CLONED GENE

  M HIRATA; A KAKIZUKA; M AIZAWA; F USHIKUBI; S NARUMIYA

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 1994, Peer-reviewed

  
• CDC25M2 ACTIVATION OF CYCLIN-DEPENDENT KINASES BY DEPHOSPHORYLATION OF THREONINE-14 AND TYROSINE-15

  B SEBASTIAN; A KAKIZUKA; T HUNTER

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1993, Peer-reviewed

  
• PML-RAR, A FUSION PROTEIN IN ACUTE PROMYELOCYTIC LEUKEMIA

  A KAKIZUKA; RM EVANS

  JOURNAL OF CELLULAR BIOCHEMISTRY, Jan. 1993

  
• REVERSE TRANSCRIPTION POLYMERASE CHAIN-REACTION FOR THE REARRANGED RETINOIC ACID RECEPTOR-ALPHA CLARIFIES DIAGNOSIS AND DETECTS MINIMAL RESIDUAL DISEASE IN ACUTE PROMYELOCYTIC LEUKEMIA

  WH MILLER; A KAKIZUKA; FRANKEL, SR; RP WARRELL; A DEBLASIO; K LEVINE; RM EVANS; E DMITROVSKY

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1992, Peer-reviewed

  

Presentations

• 加齢に伴う難治性疾患の克服に向けた挑戦

  垣塚 彰

  高等研プロジェクト「老いを考える」研究会, 23 Jan. 2015, Invited

  
• Challenges for currently incurable disorders.

  Akira Kakizuka

  The Liaison Laboratory regular seminar/ HIGO Program cutting-edge research seminar., 21 Jan. 2015, Invited

  
• インスリン抵抗性を改善する新規薬剤の開発

  垣塚 彰

  厚生労働科学研究 平成26年度研究成果発表会（研究者向け）, 20 Jan. 2015, Invited

  
• 医薬品の神経毒性

  垣塚 彰

  東京大学薬学部特別講義, 28 Oct. 2014, Invited

  
• 難病への挑戦

  垣塚 彰

  京都大学春秋講義（一般向け）, 13 Sep. 2014, Invited

  
• 新規創薬標的としての細胞内主要ATPase, VCP

  垣塚 彰

  金沢大学ニューロサイエンスセミナー, 11 Sep. 2014, Invited

  
• VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders

  Akira Kakizuka

  Innovative Medicine: Basic Research and Drug Development. (The Uehara Memorial Foundation Symposium 2014, 15 Jun. 2014, Invited

  
• 神経細胞が死ぬ病気はなぜおこるの？

  垣塚 彰

  膳所高等学校・京都大学公開講義, 23 May 2014, Invited

  
• 医薬品の神経毒性

  垣塚 彰

  東京大学薬学部特別講義, 22 Oct. 2013, Invited

  
• 新規神経保護創薬標的としての細胞内主要ATPase, VCP

  垣塚 彰

  厚労省調査研究班ワークショップ「病態に根ざしたALSの新規治療法開発」, 27 Sep. 2013, Invited

  
• 新規創薬標的としての細胞主要ATPase, VCP

  垣塚 彰

  金沢大学ニューロサイエンスセミナー, 05 Sep. 2013, Invited

  
• 癌ってどういうもの？

  垣塚 彰

  膳所高等学校・京都大学公開講義, 14 Jun. 2013, Invited

  
• 新規創薬標的としての細胞内主要ATPase, VCP

  垣塚 彰

  上原記念生命科学財団特定研究「確信的医療を創生する医学研究」シンポジウム, 14 Jun. 2013, Invited

  
• 新規の作用機序による緑内障および網膜色素変性症治療薬

  イノベーションフェア関西, 06 Dec. 2012

  
• 細胞内主要ATPase VCPの生理・病態における役割とその新規制御薬の開発

  奈良県立医大大学院セミナー, 30 Nov. 2012, 奈良県立医大

  
• 医薬品の神経毒性

  垣塚 彰

  東京大学薬学部特別講義, 06 Nov. 2012, Invited

  
• 神経変性疾患発症におけるVCP蛋白質の役割

  垣塚 彰

  金沢大学ニューロサイエンスセミナー, 30 Oct. 2012, Invited

  
• 細胞内主要ATPase VCPの役割とその新規制御薬の開発

  糖尿病研究センターセミナー/転写代謝セミナー, 19 Oct. 2012, 国立国際医療研究センター

  
• 新規神経保護薬の開発とその緑内障動物モデルに対する応用

  第23回日本緑内障学会, 28 Sep. 2012, 日本緑内障学会

  
• 緑内障および網膜色素変性症マウスモデルに対して有効性を示した新規VCP阻害剤の開発

  京都大学新技術説明会, 24 Aug. 2012, 京都大学

  
• 神経細胞が死ぬ病気はなぜおこるの？

  垣塚 彰

  膳所高等学校・京都大学公開講義, 22 Jun. 2012, Invited

  
• Roles of VCP in neurodegenerative disorders.

  The 10th NTU-Japan International mini- symposium on Molecular and Cell biology & promotion of Academic Exchange and Collaborations for NTU-Japan., 08 Jan. 2012, Kyoto University, Taiwan National University

  
• Roles of VCP in human neurodegenerative disorders.

  Kyoto University day in Nanjing., 02 Dec. 2011, Kyoto University, Nanjing University

  
• Roles of VCP in polyglutamine diseases.

  Asian Aging Core for Longevity (AACL)-Nagasaki Symposium Asian Aging 2011: Japan-Korea Joint Conference on Brain Aging and Neurodegeneration (Molecular Perspectives and Regional Bridging)., 21 Nov. 2011

  
• Roles of VCP in abnormal phospholipid metabolisms in polyglutamine disease models.

  9th International conference on AAA proteins, 10 Nov. 2011, AAA proteins

  
• VCPが関わる異常蛋白質に対するストレス応答機構とATP制御機構

  第84回日本生化学会大会シンポジウム（2S2a） ストレスシグナル研究の最前線, 22 Sep. 2011, 日本生化学会

  
• 神経変性疾患およびストレス応答におけるVCPの役割

  第20回日本Cell Death学会, 30 Jul. 2011, 日本Cell Death学会

  
• 細胞内ATPの制御機構

  第13回京都大学生命科学研究科シンポジウム, 08 Jul. 2011, 京都大学生命科学研究科

  
• 癌ってどういうもの？

  垣塚 彰

  膳所高等学校・京都大学公開講義, 06 May 2011, Invited

  
• 神経変性疾患発症におけるVCP蛋白質の役割

  垣塚 彰

  第3回グローバルCOE 国内シンポジウム「神経変性疾患とがんの共通分子機構をめぐって」, 05 Nov. 2010, Invited

  
• 医薬品の神経毒性

  垣塚 彰

  東京大学薬学部特別講義, 02 Nov. 2010, Invited

  
• 神経変性疾患発症におけるVCP蛋白質の役割

  垣塚 彰

  金沢大学ニューロサイエンスセミナー, 29 Sep. 2010, Invited

  
• 神経変性疾患発症の分子機構

  垣塚 彰

  第11回京都大学生命科学研究科シンポジウム, 01 Jul. 2010

  
• 神経細胞が死ぬ病気はなぜおこるの？

  垣塚 彰

  膳所高等学校・京都大学公開講義, 07 May 2010

  
• ストレス応答におけるVCP蛋白質の役割

  第82回日本生化学会シンポジウム「ストレス応答の新機軸」, 24 Oct. 2009, 日本生化学会

  
• 神経変性疾患に共通する発症メカニズムの解明と治療戦略の構築を目指して

  京都大学眼科セミナー, 25 Jun. 2009, 京都大学医学部

  
• A novel feedback machinery between abnormal protein accumulation and transcriptional suppression

  The 5th NTU-Kyoto-U mini-symposium on molecular and cellular biology, 23 May 2009

  
• 医薬品の神経毒性

  東京大学薬学部特別講義, 04 Nov. 2008, 東京大学薬学部

  
• 異常蛋白質の蓄積がもたらすフィードバック機構

  第９回京都大学生命科学研究科シンポジウム, 26 Jun. 2008, 京都大学生命科学研究科

  
• 分子が織りなす生命の不思議—どうして病気になるの？ 運動しても肥満は防げない？ がん・神経難病、肥満・糖尿病をめぐってー

  徳島県立総合大学校まなーびあ徳島 開校記念講演, 08 Jun. 2008, 徳島県

  
• 神経細胞が死ぬ病気はなぜおこるの？

  膳所高等学校生向け公開講座, 25 Apr. 2008, 膳所高等学校・京都大学

  
• 神経変性疾患におけるVCP蛋白質の役割

  金沢大学医学部Neuroscience Seminar, 16 Nov. 2007, 金沢大学医学部

  
• 神経変性疾患に共通する発症機序の解明を目指して

  金沢大学医学部特別講義, 16 Nov. 2007, 金沢大学医学部

  
• Roles of VCP in human neurodegenerative disorders

  7th international conference on AAA proteins, 11 Sep. 2007, AAA proteins

  
• 神経変性疾患発症におけるVCP蛋白質の役割

  第８回京都大学生命科学研究科シンポジウム, 22 Jun. 2007, 京都大学生命科学研究科

  
• 癌ってどうゆうもの

  膳所高等学校・京都大学公開講義, 27 Apr. 2007, 膳所高等学校・京都大学

  

Books and Other Publications

• 細胞死Update-基礎から臨床までを俯瞰して（別冊・医学のあゆみ）「神経変性疾患と細胞死」

  垣塚 彰

  医歯薬出版株式会社, 2014, Not refereed

  
• 改訂第3版 脳神経科学イラストレイテッド ー分子・細胞から実験技術まで「ポリグルタミン病」

  垣塚 彰

  羊土社, 2013, Not refereed

  
• Identification of Plant Extracts Containing Inhibitory Activities on γ-secretase -Identification of plant extracts that prevent Alzheimer disease-

  Kakizuka A; Sasaoka N

  In Kyoto University Research Activities 2011. Vol. 1 No.2 pp24., Nov. 2011, Not refereed

  
• 分子生物学 第２版 「ヒトの分子生物学」261-273

  垣塚 彰(編集; 柳田光弘; 西田栄介; 野田 亮

  東京化学同人, 2009, Not refereed

  Find Kyoto University's collection of books :

  
• 蛋白質・核酸・酵素「神経変性疾患」キーワード：蛋白質の一生 53: 953

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  
• 蛋白質・核酸・酵素「ハンチントン病」キーワード：蛋白質の一生 53: 983

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  Find Kyoto University's collection of books :

  
• 蛋白質・核酸・酵素「ポリグルタミン病」キーワード：蛋白質の一生 53: 1002

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  Find Kyoto University's collection of books :

  
• 「MJD1蛋白質」医学書院医学大事典 pp244m

  垣塚 彰; 総編集; 伊藤 正男; 井村 裕夫; 高久 史麿

  医学書院, 2008, Not refereed

  
• 蛋白質・核酸・酵素「マシャド・ジョセフ病」キーワード：蛋白質の一生 53: 1006

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  Find Kyoto University's collection of books :

  
• 「MJD1遺伝子」医学書院医学大事典 pp244l

  垣塚 彰; 総編集; 伊藤 正男; 井村 裕夫; 高久 史麿

  医学書院, 2008, Not refereed

  
• 蛋白質・核酸・酵素「Lewy 小体」キーワード：蛋白質の一生 53:1069

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  Find Kyoto University's collection of books :

  
• 蛋白質・核酸・酵素「核内封入体」キーワード：蛋白質の一生 53: 918

  垣塚 彰(編集; 遠藤斗志也; 小椋 光; 永田和宏; 森 和俊; 田口秀樹; 吉田賢右

  共立出版, 2008, Not refereed

  Find Kyoto University's collection of books :

  
• 脳神経科学 イラストレイテッド 改訂第2版「ポリグルタミン病」312-319

  垣塚 彰; 編集; 森 寿; 真鍋俊也; 渡辺雅彦; 岡野栄之; 宮川 剛

  羊土社, 2006, Not refereed

  
• Transcriptional regulation of human transglutaminase 1 gene by signalling systems of protein kinase C, RAR/RXR and Jun/Fos in keratinocyte. (共著)

  垣塚 彰

  Biochemistry and Molecular Biology International,34/,827, 1994, Not refereed

  
• Construction of a cDNA library from embryonic tissues. (共著)

  垣塚 彰

  In Essential Developmental Biology : A practical Approach (IRL Press),/,223, 1993, Not refereed

  
• Retinoid receptors. (共著)

  垣塚 彰

  Recent Progress in Hormone Research,48/,99, 1993, Not refereed

  
• PML-RAR, a Fusion Protein in Acute Promyelocytic Leukemia. (共著)

  垣塚 彰

  Cancer Chemotherapy,8/,150, 1993, Not refereed

  

Industrial Property Rights

• PCT/JP2014/073256, レプチン抵抗性を改善する医薬組成物

  垣塚彰

  
• 特願2014-129478, アルツハイマー病予防薬

  垣塚彰; 笹岡紀男; 兼森祥子; 坂本めぐみ; 竹本佳司; 塚野千尋

  
• 特願2014-038457, 虚血性眼疾患の処置および/または予防用の医薬組成物

  垣塚彰; 池田華子

  
• 特願2013-183265, レプチン抵抗性を改善する医薬組成物

  垣塚彰

  
• 特願2011-19043, アルツハイマー病予防薬のスクリーニング法と同定物

  垣塚 彰; 笹岡紀男; 兼森祥子; 坂本めぐみ; 竹本佳司; 塚野千尋

  
• 特願2011-102330, 抗癌剤の副作用を軽減させる薬剤・方法

  河合裕子; 垣塚彰; 堀清次

  
• 特願2013-221873, 加齢黄斑変性予防・治療薬

  垣塚彰; 堀清次; 池田華子; 村岡勇貴; 吉村長久

  
• 特願2010-221873, 眼疾患処置薬

  垣塚彰; 堀清次; 池田華子; 吉村長久; 中野紀子

  
• 特願2010-172467, ナフタレン誘導体

  垣塚彰; 堀清次

  

Awards

• 01 Sep. 1995

  日本生化学会奨励賞
• 20 Nov. 2002

  ベルツ賞

External funds: Kakenhi

• Construction of a new drug discovery platform for atopic dermatitis

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  AKIRA KAKIZUKA

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  アトピー性皮膚炎;p97/VCP;治療薬;Th2型アレルギー反応;新規治療薬;かゆみ;Th2型免疫応答;KUS121;Th2型;新規治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19375/
• Elucidation of novel functions of VCP, a major ATPase in the cell

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  Akira KAKIZUKA

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  VCP;飢餓;前立腺癌;フェロトーシス;生体応答;VCP/p97;前立腺細胞;GSH;VCP・p97;前立性癌;新規機能;細胞保護;p97/VCP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03435/
• Analyses on novel functions of VCP, a major ATPase in the cell

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Akira KAKIZUKA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  VCP/p97;ATP制御;神経細胞死;飢餓;恒常性維持;パーキンソン病;心筋梗塞;脳梗塞;VCP;ATPase;栄養飢餓;ATP;恒常性維持機構;新規機能;創薬基盤;飢餓応答;細胞死;疾患治療;細菌;蛋白質;ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05151/
• Development of neuroprotective drugs

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hanako Ikeda

  From 01 Apr. 2015, To 31 Mar. 2016, Project Closed

  神経保護;眼疾患;創薬;スクリーニング;眼難治疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15633/
• プロテアゾーム阻害下におけるユビキチン化蛋白質の除去機構の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  垣塚 彰

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  ユビキチン化;細胞内不要蛋白質;新規創薬標的;神経変性疾患;新規化合物;細胞・組織;ストレス;蛋白質;オートファジー;標的蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01181/
• Development of neuroprotective treatment for incurable ocular diseases

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Nagahisa YOSHIMURA

  From 31 Oct. 2012, To 31 Mar. 2015, Project Closed

  神経保護;眼難治疾患;眼細胞生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24249082/
• Analyses of the function and regulation of VCP, a major ATPase in the cells

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Akira KAKIZUKA

  From 31 May 2011, To 31 Mar. 2014, Project Closed

  ATP;ATPase;VCP;ERストレス;細胞死;網膜色素変性症;緑内障;酵素;胞・組織;ストレス;蛋白質;阻害剤;繊維状構造物;グルコース代謝;飢餓;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23249016/
• VCPのATPase活性を阻害する物質の検索

  Grant-in-Aid for Exploratory Research

  Kyoto University

  垣塚 彰

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  VCP;AAA ATPase;活性阻害剤;腺癌;扁平上皮癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17659092/
• 異常蛋白質が引き起こす空胞形成の分子解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  堀 清次

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ポリグルタミン;VCP;p97;神経変性疾患;AAA ATPase;ミスセンス変異;IBMPFD;凝集体形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17028028/
• Mechanisms for the regulation of growth and cell death in cancer cells

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Akira KAKIZUKA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  細胞死;AAA;ATPase;アミノ酸修飾;VCP;リン酸化;アセチル化;Cdc48;脱ユビキチン化;フィードバック機構;ペウルオキシゾーム;カタラーゼ;ROS;癌の悪性化;細胞内局在;細胞周期;紡錘体極;タイムラプス解析;p47;DNA合成;細胞増殖;AAA ATPase;出芽酵母;温度感受性株

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17014043/
• Functional analyses of VCP protein in neuronal cell death

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Akira KAKIZUKA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  VCP;神経細胞死;アミノ酸修飾;酸化;蛋白質凝集体;AAA ATPase;ポリグルタミン;神経変性疾患;ミスセンス変異;IBMPFD;凝集体形成, VCP;neuronal cell death;amino acid modification;oxidation;protein aggregates;AAA ATPase;polyglutmamine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390092/
• ポリグルタミンの凝集体形成、細胞障害におけるストレス蛋白質の役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Metropolitan Organization for Medical Research

  木村 洋子

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  アミロイド;分子シャペロン;神経変性変異;ポリグルタミン;酵母プリオン;AAA superfamily蛋白質;VCP;p97;Cdc48;cross-seeding

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16015338/
• ポリグルタミンの凝集体形成、細胞障害におけるストレス蛋白質の役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Metropolitan Organization for Medical Research

  木村 洋子

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  ポリグルタミン;分子シャペロン;凝集体;酵母;AAA+ Superfamily蛋白質;神経変性変異

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15016127/
• Development of As203-besed new chemotherapy for advanced prostate cancer

  Grant-in-Aid for Scientific Research (B)

  KAGAWA UNIVERSITY(FACULTY OF MEDICINE)

  Yoshiyuki KAKEHI

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  3酸化砒素;アポトーシス;前立腺癌;腎癌;Buthionine sulfooximine;活性化酸素;三酸化ヒ素;buthionine sulfoximine, arsenic trioxide;apoptosis;prostate cancer;renal cancer;buthionine sulfoximine;reactive oxveren species

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370514/
• Molecular analyses of cell death and vacuole formation that are induced by abnormal protein accumulation

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Akira KAKIZUKA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  ポリグルタミン;空胞形成;神経細胞死;AAA ATPase;VCP;アミノ酸修飾;Lewy小体;蛋白質凝集体;ポリグルタミ;MJD;プロセシング;空胞変性;小胞体;小胞体ストレス, polyglutamine;vacuole formation;neuronal cell death;AAA ATPase;VCP;amino acid modification;Lewy body;protein aggregates

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370057/
• 異常蛋白質が引き起こす空胞形成の分子解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  堀 清次

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  ポリグルタミン;VCP;p97;AAA ATPase;フォルディング;腺ガン;出芽酵母;polyglutamine;CFTR;ER stress;ubiquitin;Lewy body;parkinson's disease;Alzheimer's disease

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037232/
• The Role of stress proteins in the aggregation and cytotoxicity of polyglutamine

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Metropolitan Organization for Medical Research

  Yoko KIMURA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ポリグルタミン;神経変性変異;分子シャペロン;アミロイド;AAAスーパーファミリー蛋白質;凝集体;Hsp104;VCP;p97;AAA+ スーパーファミリー蛋白質;神経変性疾患;コンフォーメーション;構造変換;コンフォーメーション病;酵母, polyglutamine;neurodegerative disease;molecular chaperone;amyloid;AAA superfamily protein;aggregates;Hsp104;VCP;p97

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13210155/
• がん細胞におけるアポトーシスの分子解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Osaka Bioscience Institute

  垣塚 彰

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  ポリグルタミン;神経細胞死;AAA ATPase;アミノ酸修飾;VCP;出芽酵母;腺癌;扁平上皮癌;酸化修飾;ATPase活性;温度感受性株;細胞死;Hsp70;RNAi;細胞周期;亜砒酸;前立腺ガン;p97;APL;ASK1;酸化ストレス;SEK1;スプライニングバリアント

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12215156/
• 単一遺伝子異常による神経細胞死

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tokai University

  池田 穣衛;池田 穰衛

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  神経細胞死;ポリグルタミン病;アポトーシス;NAIP;トリブレットリピートインスタビリティー;ハンチントン病;MJD;DRPLA;ポリグルタミン酸;トリプレットリピートインスタビリティー;ダイナミックミューテーション;神経変性疾患;トリプレットリピート病;小脳変性疾患;脊髄性筋萎縮症;マシャドジュセフ病;分子医学;歯状核赤核淡蒼球ルイ体萎縮症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09280105/
• THE ANALYSIS OF PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS BASED ON THE ESTABLISHMENT OF IN VITRO MOTOR NEURONAL CELL LINES

  Grant-in-Aid for Scientific Research (C)

  Osaka Bioscience Institute

  Yasuto TANABE

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  筋萎縮性側索硬化症;運動ニューロン;転写因子;誘導;P19細胞;脊髄, MOTOR NEURON;AMYOTOROPHICLATERAL SCLEROSIS;TRANSCRIPTION FACTORS;INDUCTION;P19 CELLS;SPINALOORD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670156/
• Molecular analysis on nqurodegeneration

  Grant-in-Aid for Scientific Research (B)

  OSAKA BIOSCIENCE INSTITUTE(OBI)

  Akira KAKIZUKA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  ポリグルタミン;細胞死;VCP;p97;空胞;蛋白質凝集;神経変性疾患;アポトーシス;SEKI-JNK;PML body;ドロソフィラ, polyglutamine;Cell death;VCP;p97;vacuole;protein aggregate

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11470046/
• A novel gene transfer method for prostate-specific and potent expression and its utilization in gene therapy

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Yoshiyuki KAKEHI

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  前立腺癌;PSA;遺伝子治療;LNCAP細胞;アンドロゲン反応性;TSTAsystem;GFP;アデノウィルスベクター;LNCaP細胞;TSTA system;GEP;アデノウイルス, Prostate cancer;PSA;gene therapy;LNCaP cell;androgen responsiveness;TSTA system;GFP;adenovirus vector

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470337/
• アポトーシスの分子解析とその癌治療への応用

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Osaka Bioscience Institute

  垣塚 彰

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  癌治療;アポトーシス;ポリグルタミン;SEKI-JNK;PML body;ドロソフィラ;がん治療;タモキシフェン;SEKI

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10154203/
• Identification and analysis of the genes responsible for inherited neurodegenerative disorders

  Grant-in-Aid for Scientific Research (B)

  Osaka Bioscience Institute

  Akira KAKIZUKA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  神経細胞死;ポリグルタミン;Machado-Joseph病;CAGリピート;PC12;SEK1;ストレス応答;Machado-Josephe病;ERDA1;MJD;HD, neuronal cell death;polyglutamine;Machada-Joseph disease;CAG Repeat;PC12;SEK1;stress response

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470041/
• Target genes and biological role of transcription factors in animal

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  RIKEN INSTITUTE

  Shunsuke ISHII

  From 01 Apr. 1997, To 31 Mar. 2001, Project Closed

  転写調節;制御因子;標的遺伝子;変異マウス;転写仲介因子;発生;造血系;神経系;ノックアウトマウス;分化, transcriptional control;transcriptional regulator;target genes;mutant mice;transcriptional mediators;development;hematopoietic system;neuronal system

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09277103/
• ホルモン依存性プログラム細胞死の癌治療への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Osaka Bioscience Institute;Kyoto University

  垣塚 彰

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  癌;遺伝子治療;アポトーシス;前立腺癌;遺伝子発現;デスドメイン;ポリグルタミン;レチノイン酸;Fas;融合蛋白質;急性前骨髄球性白血病;エストロゲン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08267201/
• 遺伝性神経変性症の原因遺伝子の同定と解析

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  垣塚 彰

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  マシャド・ジョセフ病;CAGリピート;ポリグタミン;アポトーシス;小脳失調;プルキンエ細胞;ベータシート

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670172/
• ホルモン依存性プログラム細胞死の分子機構解析とその応用

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  垣塚 彰

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  fas;アポトーシス;プログラム細胞死;デスシグナル;エストロゲン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670168/
• An animal model for keratosis

  Grant-in-Aid for Scientific Research (A)

  KYOTO UNIVERSITY

  Toshihiro TANAKA

  From 01 Apr. 1995, To 31 Mar. 1998, Project Closed

  レチノイン酸受容体;トランスジェニックマウス;ドミナント・ネガティブ;角化症;レチノイン酸;ケラチン;表皮分化;K14プロモーター;ドミナント-ネガティブ;炎症性角化症;レチノイン酸レセプター;トランスジェニック マウス;皮膚特異的発現;ドミナント ナガティブ;レイノイン酸レセプター, Retinoic acid Receptor;Transgenic mouse;Dominant-negative;keratosis;Retinoic acid;keratin;keratinocyte differentiation;K14 promotor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557348/
• がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Hamamatsu University School of Medicine

  大野 竜三

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  レチノイン酸;分化誘導療法;急性前骨髄球性白血病;Am-80;細胞内レチノイン酸結合蛋白;ユビキチン・プロテアゾーム;トランスジェニック・マウス;レチノイドアンタゴニスト

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07274107/
• 遺伝性神経変性疾患の分子機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  垣塚 彰

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  CAG;MJD;神経細胞死;優性遺伝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07264220/
• 急性前骨髄球性白血病の発症及び寛解機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  垣塚 彰

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  APL;PML;RAR;ドミナント・ネガティブ;皮フ成型

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07258211/
• rho p21 in Neural Development and Plasticity

  Grant-in-Aid for international Scientific Research

  KYOTO UNIVERSITY

  Akira KAKIZUKA

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  rhop21;p160ROCK;細胞接着斑;インテグリン;p140mDia;アクチン重合;神経可塑性;細胞接着;rho p21;ボツリヌスC_3酵素;PKN;P160^;細胞形態変化;SH_3, rho p21;p160ROCK;focal adhesion;intergrin;p140mDia;actin polymerization;Neural plasticity;cell adhesion

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044248/
• ホルモン依存性プログラム細胞死の開発と応用

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  垣塚 彰

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  プログラム細胞死;アポトーシス;エストロジェン;レチノイン酸;fas;遺伝子治療;疾患モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670167/
• 造血器腫瘍における転座関連遺伝子の機能とその臨床応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Hiroshima University

  鎌田 七男

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  造血器腫瘍;転座関連遺伝子;FISH;AML1遺伝子;BCL2遺伝子;MLL遺伝子;GCL6遺伝子;遺伝子機能;染色体異常;PCR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06282114/
• がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Hamamatsu University School of Medicine

  大野 竜三

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  分子誘導療法;レチノイン酸;レチノイド;急性前骨髄球性白血病;レチノイン酸レセプター;PML;ポリプレン酸;ブファリン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06282109/
• 急性前骨髄球性白血病の発症及び寛解機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  垣塚 彰

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  白血病;染色体転座;PML;RAR;APL;抗核抗体;ドミナント・ネガティブ;トランスジェニック・マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06266207/
• Information Exchange on Cancer Research with North American

  Grant-in-Aid for international Scientific Research

  The University of Tokyo

  Tadashi YAMAMOTO

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  国際学術;海外派遣;癌;細胞社会学;シグナル伝達;細胞周期;薬品設計;遺伝子治療;ウイルス発癌;細胞接着;癌治療;化学発癌;情報交換;ドラッグデザイン;癌遺伝子治療;癌化学療法;細胞増殖, International Scientific Research;Cancer;Information Exchange;Signal Transduction;Cell Cycle;Cell Adhesion;Drug Design;Gene Therapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042003/
• ホルモン依存性プログラム細胞死の開発と応用

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  垣塚 彰

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  プログラム細胞死;fas抗原;脂溶性ホルモン;受容体;遺伝子療法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05670138/
• Structures and functions of the Prostanoid Receptors

  Grant-in-Aid for General Scientific Research (A)

  KYOTO UNIVERSITY

  Shuh NARUMIYA

  From 01 Apr. 1993, To 31 Mar. 1996, Project Closed

  プロスタグランジン受容体;トロンボキサン受容体;受容体リガンド結合;細胞内情報伝達;受容体アイソフォーム;受容体遺伝子;体内分布;トロンボキサン受容体異常症;プロスタノイド受容体分子進化;プロスタサイクリン受容体体内分布;トロンボキサン受容体アイソフォーム;ラット脳EP_3受容体;プロスタグランジン受容体遺伝子;プロスタグランジン;トロンボキサン;受容体;G蛋白質;情報伝達;血小板異常症;脳内分布;遺伝子;アポプトーシス;胸腺, prostaglandin;thromboxane receptor;ligand binding;signal transduction;receptor isoform;gene receptor;receptor distribution;receptor abnormality

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05404020/
• 急性前骨髄球性白血病の発症及び寛解機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  垣塚 彰

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  白血病;染色体転座;PML;RAR;APL;抗核抗体;ドミナント・ネガティブ;寛解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05273210/
• 細胞の機能分化に関わる遺伝子制御ネッドワーク-遺伝子の階層的制御システム-

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  岩渕 雅樹

  From 01 Apr. 1993, To 31 Mar. 1997, Project Closed

  基本転写因子;特異的転写調節因子;転写因子復合体;転写因子ファミリー;細胞機能制御;細胞増殖・分化;遺伝子欠損マウス;転写因子ネットワーク;機能ドメイン;細胞機能;転写活性化機構;遺伝子特異的転写因子;ノックアウト・マウス;転写調節因子;DNA非結合型因子;胚発生;HBP-1a;IRF-1,-2;細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05273102/
• 造血器腫瘍における転座関連遺伝子の機能とその臨床応用

  Grant-in-Aid for Cancer Research

  Hiroshima University

  鎌田 七男

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  造血器腫瘍;転座関連遺伝子;遺伝子機能;染色体異常;FISH;PCR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05151048/
• Building a new therapeutic platform for cancer by inducing cellular senescence

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  垣塚 彰

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  細胞老化;癌治療;化合物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18215/

External funds: others

• Molecular analysis of Neuro-degenerative diseases
• Cancer gene therapy
• Retinoid biology
• アルツハイマー病予防効果をもつ漢方薬とその有効成分の同定

  厚生労働科学研究費補助金（創薬基盤推進研究事業）

  From 2010, To 31 Mar. 2013

  垣塚彰

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Career Paths in Life Sciences

  M507, Spring, Institute for Liberal Arts and Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Career Paths in Life Sciences

  5005, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Immunology and Human Disorders

  1031, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Cancer Biology

  1022, Fall, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  1035, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Career Paths in Life Sciences

  5005, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Global Frontier in Life Science A

  1018, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Cancer Biology

  1022, Fall, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Immunology and Human Disorders

  1031, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Career Paths in Life Sciences

  M507, Spring, Institute for Liberal Arts and Sciences, 1
• From Apr. 2011, To Mar. 2012

  Perspectives on Life Science A

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Perspectives on Life Science B

  Fall, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2011, To Mar. 2012

  先端生命科学

  Year-long, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  分子細胞生物学

  Fall, 総合生存学館
• From Apr. 2014, To Mar. 2015

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  Fall, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar l

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar 2

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar 2

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Experiments in Systemic Life Sciences

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar l

  Year-long, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Career Paths in Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Career Paths in Life Sciences

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Career Paths in Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Career Paths in Life Sciences

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Career Paths in Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Basics in Medical Biology

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Career Paths in Life Sciences

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Career Paths in Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :Basics in Medical Biology

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Career Paths in Life Sciences

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Career Paths in Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科

Participation in PhD Defense

• Constitutively active signaling of MDA5 in Treg cells causes apoptosis of Treg cells and results in autoimmune diseases

  LEE SUMIN, Graduate School of Biostudies, Sub-chief Examiner

  23 Jan. 2023
• PC3 prostate cancer cells require VCP relocalization to adapt to starvation stress, via regulation of mitochondrial activity.

  OGOR PROMISE, Graduate School of Biostudies, Chief Examiner

  24 Sep. 2021

Part-time lecturer

• From 01 Oct. 2023, To 31 Mar. 2024

  東京大学
• From 01 Sep. 2022, To 31 Mar. 2023

  東京大学
• From 01 Apr. 2015, To 31 Mar. 2016

  金沢大学, 医薬保健学域
• From 01 Apr. 2015, To 31 Mar. 2016

  東京大学, 薬学部
• From 01 Apr. 2016, To 31 Mar. 2017

  金沢大学
• From 01 Apr. 2016, To 31 Mar. 2017

  東京大学
• From 01 Apr. 2017, To 31 Mar. 2018

  金沢大学
• From 26 Apr. 2017, To 31 Mar. 2018

  東京大学, 薬学部
• From 01 Apr. 2018, To 31 Mar. 2019

  金沢大学
• From 01 Apr. 2018, To 31 Mar. 2019

  東京大学, 薬学部
• From 01 Apr. 2019, To 31 Mar. 2021

  金沢大学
• From 01 Sep. 2019, To 31 Mar. 2020

  東京大学, 薬学部
• From 01 Oct. 2020, To 31 Mar. 2021

  東京大学, 薬学部
• From 01 Apr. 2021, To 31 Mar. 2022

  金沢大学
• From 01 Oct. 2021, To 31 Mar. 2022

  東京大学, 薬学部

Administration

School management (title, position)

• From 01 Apr. 2008, To 31 Mar. 2010

  発明評価委員会（メディカル・バイオ分野拠点） 委員
• From 01 Apr. 2009, To 31 Mar. 2013

  全学共通教育システム委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2017

  大学評価委員会点検・評価実行委員会 委員
• From 25 Nov. 2009, To 31 Mar. 2014

  K.U.PROFILEプロジェクト実行委員会委員
• From 01 Apr. 2017, To 30 Sep. 2018

  企画委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  研究倫理・安全推進委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  大学院生命科学研究科長
• From 01 Apr. 2017, To 31 Mar. 2018

  博士課程教育リーディングプログラム運営会議 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  教育研究評議会 評議員
• From 01 Apr. 2017, To 31 Mar. 2019

  部局長会議
• From 01 Apr. 2017, To 31 Mar. 2019

  研究科長部会
• From 01 Apr. 2017, To 31 Mar. 2019

  人事審査委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  先端科学研究基盤共用促進事業検討ワーキンググループ委員
• From 01 Apr. 2017, To 31 Mar. 2019

  国際高等教育院 大学院共通・横断教育基盤協議会 協議員
• From 01 Apr. 2017, To 31 Mar. 2019

  研究公正推進委員会 委員
• From 16 May 2017, To 31 Mar. 2018

  研究活動上の行動規範に関する検討ワーキンググループ 委員
• From 01 Apr. 2017

  補導会議　構成員
• From 01 Apr. 2017, To 31 Mar. 2019

  環境安全保健機構運営協議会　構成員
• From 01 Apr. 2017, To 31 Mar. 2021

  生命科学研究科 研究科長
• From 01 Oct. 2018, To 30 Sep. 2020

  企画委員会 委員
• From 24 Jul. 2018, To 30 Sep. 2020

  企画委員会On-site Laboratory認定専門委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  京都大学情報環境整備委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  国際高等教育院 大学院共通・横断教育基盤協議会 協議員
• From 01 Apr. 2017, To 31 Mar. 2021

  研究公正推進委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2021

  研究公正委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  研究倫理・安全推進委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  施設整備委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2021

  教育研究評議会 評議員
• From 01 Apr. 2017, To 31 Mar. 2021

  部局長会議
• From 01 Apr. 2017, To 31 Mar. 2021

  研究科長部会
• From 01 Apr. 2020, To 31 Mar. 2021

  国際高等教育院 大学院共通・横断教育基盤協議会 協議員
• From 15 May 2018, To 31 Mar. 2021

  大学院横断教育プログラム推進センター運営協議会 協議員
• From 01 Apr. 2020, To 31 Mar. 2022

  京都大学体育会 会長
• From 01 Oct. 2020, To 31 Mar. 2021

  基金運営委員会 委員