Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医科学専攻 呼吸器再生医学, 教授
• Graduate School of Medicine, 医学専攻 呼吸器再生医学, 教授

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Apr. 2024, To Present

  日本呼吸器学会, 将来計画委員会, 委員
• From Apr. 2024, To Present

  Japanese Respiratory Society, 学術部会統合委員会, 委員
• From Feb. 2024, To Present

  日本呼吸器学会, 代議員
• From May 2023, To Present

  日本呼吸器学会, 細胞・分子生物学学術部会, 副部会長
• From Dec. 2020, To Mar. 2024

  日本呼吸器学会, COVID-19 診療 expert opinion ワーキング委員会, 委員
• From Jul. 2022, To Present

  Kyoto University, Department of Clinical Application, Center for iPS Cell Research and Application, 教授
• From Apr. 2017, To Jun. 2022

  Kyoto University, 大学院医学研究科 呼吸器疾患創薬講座・呼吸器内科学, 特定准教授
• From Mar. 2015, To Mar. 2017

  Kyoto University, 医学部附属病院 呼吸器内科, 特定助教
• From Sep. 2014, To Feb. 2015

  Kyoto University, 医学部附属病院 呼吸器内科, 医員
• From Oct. 2008, To Mar. 2009

  国立病院機構 南京都病院, 呼吸器内科
• From Apr. 2004, To Sep. 2008

  聖路加国際病院, 内科・呼吸器内科, 初期研修医・後期研修医

ID,URL

• J-Global ID

  201501056066723128

researchmap URL

• https://researchmap.jp/7000011372

Research

Research Topics, Overview of the research

• Research Topics

  My visions are the innovation for unmet medical needs in pulmonology and the translational research from bench sides to bed sides, growing good physician and researchers.

• Overview of the research

  Human cell-based disease modeling has been expected to provide the tools for finding novel therapeutic targets or agents. However, there have been limitations of obtaining a sufficient amount of patients’ lung specimens. In this era of stem cell technologies, pluripotent stem cells could be the alternative resource for bona fide human cells and we have worked on establishing the robust methods of generating functional lung cells from human induced pluripotent stem cells (hiPSCs). Both airway and alveolar cells could be efficiently induced from hiPSCs, respectively. We then started to apply these induction methods to refractory lung disease modelings for novel drug discovery and studies for lung regeneration.

Research Interests

• 幹細胞、細胞生物学、発生学、呼吸器、気道、肺胞

Research Areas

• Life sciences, Experimental pathology
• Life sciences, Respiratory medicine

Papers

• Influence of Educational Films on Antiviral Prescription for COVID-19: Insights from Web-Based Survey in Japan

  Kosaku Komiya; Akihiko Hagiwara; Yuichiro Shindo; Kazufumi Takamatsu; Naoki Nishimura; Yukako Takechi; Eiki Ichihara; Takahiro Takazono; Shinyu Izumi; Shimpei Gotoh; Seiichiro Sakao; Takehiro Izumo; Kazuko Yamamoto; Kazuhiro Yatera; Hiroshi Kakeya; Yoko Shibata; Keisuke Tomii; Hironori Sagara; Yuka Sasaki; Toyohiro Hirai; Akihito Yokoyama; Hiroshi Mukae; Takashi Ogura

  Antibiotics, 07 Mar. 2025, Peer-reviewed

  
• Micro-physiological system of human lung: The current status and application to drug discovery.

  Naoyuki Sone; Shimpei Gotoh

  Drug metabolism and pharmacokinetics, Feb. 2025, Peer-reviewed, Invited, Last author, Corresponding author

  
• [Development of human iPS cell-derived alveolar and airway models using micropatterning plate for SARS-CoV-2 research].

  Rina Hashimoto; Atsushi Masui; Shimpei Gotoh; Kazuo Takayama

  Uirusu, 2024

  
• Generation and isolation of alveolar type II cells from human pluripotent stem cells

  Gotoh, S.; Mishima, M.

  Respiration and Circulation, 2015

  
• [Two cases of invasive pulmonary aspergillosis mimicking pneumonia in lung cancer patients].

  Horinouchi, H.; Yamao, S.; Gotoh, S.; Jinta, T.; Nishimura, N.; Suzuki, K.; Chohnabayashi, N.

  Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2009

  
• A 3000-year-old founder variant in the DRC1 gene causes primary ciliary dyskinesia in Japan and Korea.

  Ryotaro Hashizume; Yifei Xu; Makoto Ikejiri; Shimpei Gotoh; Kazuhiko Takeuchi

  Journal of human genetics, 16 Aug. 2024

  
• Corrigendum: ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells.

  Ryo Niwa; Kouji Sakai; Mandy Siu Yu Lung; Tomoko Matsumoto; Ryuta Mikawa; Shotaro Maehana; Masato Suzuki; Yuki Yamamoto; Thomas L Maurissen; Ai Hirabayashi; Takeshi Noda; Makoto Kubo; Shimpei Gotoh; Knut Woltjen

  Frontiers in cell and developmental biology, 2024, Corresponding author

  
• Two Pediatric Cases of Primary Ciliary Dyskinesia Caused by Loss-of-Function Variants in Oral-Facial-Digital Syndrome Gene, OFD1.

  Yifei Xu; Yuki Tsurinaga; Tsubasa Matsumoto; Ryuji Muta; Taichi Yano; Hiroshi Sakaida; Sawako Masuda; Koki Ueda; Guofei Feng; Shimpei Gotoh; Satoru Ogawa; Makoto Ikejiri; Kaname Nakatani; Mizuho Nagao; Masaki Tanabe; Kazuhiko Takeuchi

  Case reports in genetics, 2024

  
• Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.

  Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh

  Stem cell reports, 09 Apr. 2024, Last author, Corresponding author

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• Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells.

  Yuko Ohnishi; Atsushi Masui; Takahiro Suezawa; Ryuta Mikawa; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Stem cell reports, 09 Apr. 2024, Last author, Corresponding author

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• Practical guide for the diagnosis and management of primary ciliary dyskinesia.

  Kazuhiko Takeuchi; Miki Abo; Hiroshi Date; Shimpei Gotoh; Atsushi Kamijo; Takeshi Kaneko; Naoto Keicho; Satoru Kodama; Goro Koinuma; Mitsuko Kondo; Sawako Masuda; Eri Mori; Kozo Morimoto; Mizuho Nagao; Atsuko Nakano; Kaname Nakatani; Naoya Nishida; Tomoki Nishikido; Hirotatsu Ohara; Yosuke Okinaka; Hiroshi Sakaida; Koji Shiraishi; Isao Suzaki; Ichiro Tojima; Yasuhiro Tsunemi; Keigo Kainuma; Nobuo Ota; Sachio Takeno; Shigeharu Fujieda

  Auris, nasus, larynx, 26 Mar. 2024

  
• Past and Future of Alveolar Organoids for Lung Regenerative Medicine.

  Ryuta Mikawa; Shimpei Gotoh

  Stem cells (Dayton, Ohio), 25 Mar. 2024, Last author, Corresponding author

  
• Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

  Gen Shiratsuchi; Satoshi Konishi; Tomoki Yano; Yuichi Yanagihashi; Shogo Nakayama; Tatsuya Katsuno; Hiroka Kashihara; Hiroo Tanaka; Kazuto Tsukita; Koya Suzuki; Elisa Herawati; Hitomi Watanabe; Toyohiro Hirai; Takeshi Yagi; Gen Kondoh; Shimpei Gotoh; Atsushi Tamura; Sachiko Tsukita

  EMBO Reports, 05 Feb. 2024

  
• ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells

  Ryo Niwa; Kouji Sakai; Mandy Siu Yu Lung; Tomoko Matsumoto; Ryuta Mikawa; Shotaro Maehana; Masato Suzuki; Yuki Yamamoto; Thomas L. Maurissen; Ai Hirabayashi; Takeshi Noda; Makoto Kubo; Shimpei Gotoh; Knut Woltjen

  Frontiers in Cell and Developmental Biology, 08 Dec. 2023, Peer-reviewed, Corresponding author

  
• Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

  Motoyasu Hosokawa; Ryuta Mikawa; Atsuko Hagiwara; Yukiko Okuno; Tomonari Awaya; Yuki Yamamoto; Senye Takahashi; Haruka Yamaki; Mitsujiro Osawa; Yasuhiro Setoguchi; Megumu K. Saito; Shinji Abe; Toyohiro Hirai; Shimpei Gotoh; Masatoshi Hagiwara

  iScience, Aug. 2023, Peer-reviewed, Corresponding author

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• Contemporary and emerging technologies for research in children's rare and interstitial lung disease

  Rongbo Li; Naoyuki Sone; Shimpei Gotoh; Xin Sun; James S. Hagood

  Pediatric Pulmonology, 19 May 2023, Peer-reviewed

  
• Replicative capacity of SARS-CoV-2 omicron variants BA.5 and BQ.1.1 at elevated temperatures

  Yukiko Muramoto; Senye Takahashi; Peter J Halfmann; Shimpei Gotoh; Takeshi Noda; Yoshihiro Kawaoka

  The Lancet Microbe, Apr. 2023, Peer-reviewed

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• iPSC-derived mesenchymal cells that support alveolar organoid development

  Koji Tamai; Kouji Sakai; Haruka Yamaki; Keita Moriguchi; Koichi Igura; Shotaro Maehana; Takahiro Suezawa; Kazuaki Takehara; Masatoshi Hagiwara; Toyohiro Hirai; Shimpei Gotoh

  Cell Reports Methods, Oct. 2022, Last author, Corresponding author

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• A Novel Homozygous Variant in GAS2L2 in Two Sisters with Primary Ciliary Dyskinesia.

  Guofei Feng; Yifei Xu; Shun Saso; Hajime Sasano; Shigeto Kondoh; Hidetoshi Itani; Shimpei Gotoh; Mizuho Nagao; Makoto Ikejiri; Masaki Tanabe; Kazuhiko Takeuchi

  Internal medicine (Tokyo, Japan), 2022, Peer-reviewed

  
• Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis.

  Yifei Xu; Guofei Feng; Taichi Yano; Sawako Masuda; Mizuho Nagao; Shimpei Gotoh; Makoto Ikejiri; Masaki Tanabe; Kazuhiko Takeuchi

  Journal of human genetics, 02 Mar. 2023, Peer-reviewed

  
• 難治性疾患克服を目指した次世代の治療ターゲット研究 ヒトiPS細胞を用いた呼吸器上皮細胞への分化誘導技術と細胞ファイバ技術を融合した新たな培養メソッドで切り開く肺再生研究の未来

  池尾 聡; 山本 佑樹; 池田 和弘; 曽根 尚之; 興梠 陽平; 平井 豊博; 後藤 慎平

  日本呼吸器学会誌, Apr. 2022, Last author, Corresponding author

  
• 【間質性肺疾患の研究と診療UPDATE】ヒトiPS細胞由来肺胞オルガノイド技術を基盤とした間質性肺炎への橋渡し研究

  三河 隆太; 後藤 慎平

  医学のあゆみ, Oct. 2022, Last author, Corresponding author

  
• A pediatric case of primary ciliary dyskinesia caused by novel copy number variation in PIH1D3

  Yifei Xu; Satoru Ogawa; Yuichi Adachi; Naoyuki Sone; Shimpei Gotoh; Makoto Ikejiri; Kaname Nakatani; Kazuhiko Takeuchi

  Auris Nasus Larynx, Oct. 2022, Peer-reviewed

  
• Analysis of the clinical features of Japanese patients with primary ciliary dyskinesia

  Kazuki Chiyonobu; Yifei Xu; Guofei Feng; Shun Saso; Satoru Ogawa; Makoto Ikejiri; Miki Abo; Mitsuko Kondo; Shimpei Gotoh; Hisami Kubo; Koa Hosoki; Mizuho Nagao; Takao Fujisawa; Kaname Nakatani; Kazuhiko Takeuchi

  Auris Nasus Larynx, Apr. 2022, Peer-reviewed

  
• Perspectives of future lung toxicology studies using human pluripotent stem cells

  Atsushi Masui; Toyohiro Hirai; Shimpei Gotoh

  Archives of Toxicology, Feb. 2022, Peer-reviewed, Invited, Last author, Corresponding author

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• The importance of central airway dilatation in patients with bronchiolitis obliterans.

  Mariko Kogo; Hisako Matsumoto; Naoya Tanabe; Toyofumi F Chen-Yoshikawa; Naoki Nakajima; Akihiko Yoshizawa; Tsuyoshi Oguma; Susumu Sato; Natsuko Nomura; Chie Morimoto; Hironobu Sunadome; Shimpei Gotoh; Akihiro Ohsumi; Hiroshi Date; Toyohiro Hirai

  ERJ open research, Oct. 2021, Peer-reviewed

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• Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

  Takahiro Suezawa; Shuhei Kanagaki; Keita Moriguchi; Atsushi Masui; Kazuhisa Nakao; Masayasu Toyomoto; Koji Tamai; Ryuta Mikawa; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Stem Cell Reports, Nov. 2021, Peer-reviewed, Last author, Corresponding author

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• Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs

  Takahiro Suezawa; Shuhei Kanagaki; Yohei Korogi; Kazuhisa Nakao; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Respiratory Research, Nov. 2021, Peer-reviewed, Last author, Corresponding author

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• Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology

  Naoyuki Sone; Satoshi Konishi; Koichi Igura; Koji Tamai; Satoshi Ikeo; Yohei Korogi; Shuhei Kanagaki; Toshinori Namba; Yuki Yamamoto; Yifei Xu; Kazuhiko Takeuchi; Yuichi Adachi; Toyofumi F. Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Sachiko Tsukita; Toyohiro Hirai; Yu-suke Torisawa; Shimpei Gotoh

  Science Translational Medicine, 07 Jul. 2021, Peer-reviewed, Last author, Corresponding author

  
• Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo

  Satoshi Ikeo; Yuki Yamamoto; Kazuhiro Ikeda; Naoyuki Sone; Yohei Korogi; Lucia Tomiyama; Hisako Matsumoto; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Biomaterials, Jul. 2021, Peer-reviewed, Last author, Corresponding author

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• Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells.

  Shuhei Kanagaki; Takahiro Suezawa; Keita Moriguchi; Kazuhisa Nakao; Masayasu Toyomoto; Yuki Yamamoto; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  American journal of respiratory cell and molecular biology, 25 Jan. 2021, Peer-reviewed, Last author, Corresponding author

  
• A pediatric case of productive cough caused by novel variants in DNAH9.

  Kazuhiko Takeuchi; Yifei Xu; Satoru Ogawa; Makoto Ikejiri; Kaname Nakatani; Shimpei Gotoh; Satoko Usui; Sawako Masuda; Mizuho Nagao; Takao Fujisawa

  Human genome variation, 15 Jan. 2021, Peer-reviewed

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• MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.

  Xin Yin; Laura Riva; Yuan Pu; Laura Martin-Sancho; Jun Kanamune; Yuki Yamamoto; Kouji Sakai; Shimpei Gotoh; Lisa Miorin; Paul D De Jesus; Chih-Cheng Yang; Kristina M Herbert; Sunnie Yoh; Judd F Hultquist; Adolfo García-Sastre; Sumit K Chanda

  Cell reports, 12 Jan. 2021, Peer-reviewed

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• Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.

  Shuhei Kanagaki; Satoshi Ikeo; Takahiro Suezawa; Yuki Yamamoto; Masahide Seki; Toyohiro Hirai; Masatoshi Hagiwara; Yutaka Suzuki; Shimpei Gotoh

  Stem cells (Dayton, Ohio), Nov. 2020, Peer-reviewed, Last author, Corresponding author

  
• A method of generating alveolar organoids using human pluripotent stem cells

  Yuki Yamamoto; Yohei Korogi; Toyohiro Hirai; Shimpei Gotoh

  Methods in Cell Biology, 17 Mar. 2020, Peer-reviewed, Invited, Last author, Corresponding author

  
• Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population.

  Kazuhiko Takeuchi,; Yifei Xu; Kitano Masako; Kazuki Chiyonobu; Miki Abo; Koji Ikegami; Satoru Ogawa; Makoto Ikejiri; Mitsuko Kondo; Shimpei Gotoh; Mizuho Nagao; Takao Fujisawa; Kaname Nakatani

  Molecular genetics & genomic medicine, 20 Jan. 2020, Peer-reviewed

  
• ヘルマンスキー・パドラック症候群2型患者由来iPS細胞を用いて2型肺胞上皮細胞の機能異常を再現する

  興梠 陽平; 後藤 慎平; 池尾 聡; 山本 佑樹; 曽根 尚之; 玉井 浩二; 浅香 勲; 堀田 秋津; 平井 豊博

  日本肺サーファクタント・界面医学会雑誌, Oct. 2019

  
• Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.

  Satoshi Konishi; Tomoki Yano; Hiroo Tanaka; Tomoaki Mizuno; Hatsuho Kanoh; Kazuto Tsukita; Toshinori Namba; Atsushi Tamura; Shigenobu Yonemura; Shimpei Gotoh; Hisako Matsumoto; Toyohiro Hirai; Sachiko Tsukita

  Life science alliance, Aug. 2019, Peer-reviewed

  
• Erratum: In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids (Stem Cell Reports (2019) 12(3) (431–440), (S2213671119300165), (10.1016/j.stemcr.2019.01.014))

  Korogi, Y.; Gotoh, S.; Ikeo, S.; Yamamoto, Y.; Sone, N.; Tamai, K.; Konishi, S.; Nagasaki, T.; Matsumoto, H.; Ito, I.; Chen-Yoshikawa, T.F.; Date, H.; Hagiwara, M.; Asaka, I.; Hotta, A.; Mishima, M.; Hirai, T.

  Stem Cell Reports, 09 Jul. 2019, Peer-reviewed, Corresponding author

  
• ヒトiPS細胞由来肺胞オルガノドを用いたHermansky-Pudlak症候群2型の疾患モデリング

  興梠 陽平; 後藤 慎平; 池尾 聡; 山本 佑樹; 曽根 尚之; 玉井 浩二; 小西 聡史; 長崎 忠雄; 松本 久子; 伊藤 功朗; 陳 豊史; 伊達 洋至; 萩原 正敏; 浅香 勲; 堀田 秋津; 三嶋 理晃; 平井 豊博

  組織培養研究, Jun. 2019, Peer-reviewed

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 05 Mar. 2019, Peer-reviewed, Corresponding author

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• Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea

  Okuyama, H.; Ohnishi, H.; Nakamura, R.; Yamashita, M.; Kishimoto, Y.; Tateya, I.; Suehiro, A.; Gotoh, S.; Takezawa, T.; Nakamura, T.; Omori, K.

  Journal of Tissue Engineering and Regenerative Medicine, 26 Feb. 2019, Peer-reviewed

  
• 【呼吸器領域の治療における展望と問題点】基礎医学とのダイアローグ ヒトiPS細胞による肺の再生医療

  池尾 聡; 後藤 慎平

  THE LUNG-perspectives, Nov. 2018, Last author, Corresponding author

  
• iPS細胞由来の増殖可能な肺胞上皮II型細胞を含むヒトの発生中肺胞モデル(A Model of Human Developing Alveoli Involving Expandable Alveolar Epithelial Type II cells Derived from iPS Cells)

  Yamamoto Yuki; Gotoh Shimpei; Korogi Yohei; Seki Masahide; Konishi Satoshi; Ikeo Satoshi; Sone Naoyuki; Nagasaki Tadao; Matsumoto Hisako; Muro Shigeo; Ito Isao; Hirai Toyohiro; Kohno Takashi; Suzuki Yutaka; Mishima Michiaki

  日本呼吸器学会誌, Mar. 2018, Corresponding author

  
• オルガノイド形成下におけるヒトiPS細胞由来肺胞幹細胞の長期培養とその細胞不均一性

  山本 佑樹; 後藤 慎平; 興梠 陽平; 関 真秀; 小西 聡史; 池尾 聡; 曽根 尚之; 長崎 忠雄; 松本 久子; 室 繁郎; 伊藤 功朗; 平井 豊博; 河野 隆志; 鈴木 穣; 三嶋 理晃

  生命科学系学会合同年次大会, Dec. 2017, Corresponding author

  
• Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

  Yuki Yamamoto; Shimpei Gotoh; Yohei Korogi; Masahide Seki; Satoshi Konishi; Satoshi Ikeo; Naoyuki Sone; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Isao Ito; Toyohiro Hirai; Takashi Kohno; Yutaka Suzuki; Michiaki Mishima

  NATURE METHODS, Nov. 2017, Peer-reviewed, Corresponding author

  
• iPS細胞と呼吸器上皮細胞

  興梠 陽平; 後藤 慎平

  呼吸器内科, Jul. 2017, Last author, Corresponding author

  
• ヒトiPS細胞から機能的な気道線毛上皮細胞への分化誘導

  Satoshi Konishi; Shimpei Gotoh; Kazuhiro Tateishi; Yuki Yamamoto; Yohei Korogi; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Isao Ito; Sachiko Tsukita; Michiaki Mishima

  日本呼吸器学会誌, Mar. 2016, Corresponding author

  
• Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

  Satoshi Konishi; Shimpei Gotoh; Kazuhiro Tateishi; Yuki Yamamoto; Yohei Korogi; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Isao Ito; Sachiko Tsukita; Michiaki Mishima

  STEM CELL REPORTS, Jan. 2016, Peer-reviewed, Corresponding author

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• ヒトiPS細胞から気道線毛上皮細胞への分化誘導

  小西 聡史; 後藤 慎平; 立石 和博; 山本 佑樹; 興梠 陽平; 長崎 忠雄; 松本 久子; 室 繁郎; 平井 豊博; 伊藤 功朗; 月田 早智子; 三嶋 理晃

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Corresponding author

  
• ヒト多能性幹細胞から呼吸器上皮細胞への分化誘導

  後藤 慎平; 小西 聡史; 山本 佑樹; 興梠 陽平; 長崎 忠雄; 松本 久子; 室 繁郎; 平井 豊博; 伊藤 功朗; 三嶋 理晃

  日本細胞生物学会大会講演要旨集, Jun. 2015, Corresponding author

  
• Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

  Shimpei Gotoh; Isao Ito; Tadao Nagasaki; Yuki Yamamoto; Satoshi Konishi; Yohei Korogi; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Michinori Funato; Shin-Ichi Mae; Taro Toyoda; Aiko Sato-Otsubo; Seishi Ogawa; Kenji Osafune; Michiaki Mishima

  STEM CELL REPORTS, Sep. 2014, Peer-reviewed, Lead author, Corresponding author

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• Infection 57 Years after Plombage

  Shimpei Gotoh; Naohiko Chohnabayash

  NEW ENGLAND JOURNAL OF MEDICINE, Jun. 2009, Peer-reviewed, Lead author, Corresponding author

  
• Adrenal function in patients with community-acquired pneumonia

  S. Gotoh; N. Nishimura; O. Takahashi; H. Shiratsukar; H. Horinouchi; H. Ono; N. Uchiyama; N. Chohnabayashi

  EUROPEAN RESPIRATORY JOURNAL, Jun. 2008, Peer-reviewed, Lead author, Corresponding author

  
• Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

  T Nitta; M Hata; S Gotoh; Y Seo; H Sasaki; N Hashimoto; M Furuse; S Tsukita

  JOURNAL OF CELL BIOLOGY, May 2003, Peer-reviewed

  
• Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments

  Y Kiuchi-Saishin; S Gotoh; M Furuse; A Takasuga; Y Tano; S Tsukita

  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Apr. 2002, Peer-reviewed

  

Misc.

• 閉塞性細気管支炎における気管支拡張の意義について

  古郷 摩利子; 松本 久子; 田辺 直也; 芳川 豊史; 中島 直樹; 吉澤 明彦; 小熊 毅; 佐藤 晋; 野村 奈都子; 森本 千絵; 砂留 広伸; 後藤 慎平; 大角 明宏; 伊達 洋至; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 難治性疾患克服を目指した次世代の治療ターゲット研究 ヒトiPS細胞を用いた呼吸器上皮細胞への分化誘導技術と細胞ファイバ技術を融合した新たな培養メソッドで切り開く肺再生研究の未来

  池尾 聡; 山本 佑樹; 池田 和弘; 曽根 尚之; 興梠 陽平; 平井 豊博; 後藤 慎平

  日本呼吸器学会誌, Apr. 2022

  
• Reconstruction of human lung cell community using iPS cells

  後藤慎平; 後藤慎平

  日本再生医療学会総会(Web), 2022

  
• Development of airway chip with controlled multicellular planar cell polarity for application to airway disease modeling

  曽根尚之; 後藤慎平; 後藤慎平

  医学のあゆみ, 2022

  
• 肺のバイオエンジニアリング/オルガノイド研究 ヒトiPS細胞を用いた疾患モデル開発

  後藤 慎平

  日本呼吸器学会誌, Apr. 2021

  
• ヒト多能性幹細胞から分化誘導した気道・肺胞オルガノイドの応用

  後藤慎平

  日本再生医療学会総会(Web), 2021

  
• Human iPS cell-based lung disease modeling

  後藤慎平; 後藤慎平

  日本呼吸器学会誌(Web), 2021

  
• Clinical Impact and Features of Airway Dilation in Bronchiolitis Obliterans

  古郷摩利子; 松本久子; 田辺直也; 芳川豊史; 中島直樹; 吉澤明彦; 小熊毅; 佐藤晋; 野村奈都子; 森本千絵; 砂留広伸; 後藤慎平; 大角明宏; 伊達洋至; 平井豊博

  日本呼吸器学会誌(Web), 2021

  
• 【間質性肺炎診療の今・未来】間質性肺疾患研究の最前線 iPS細胞を用いた間質性肺炎研究

  玉井 浩二; 後藤 慎平

  Pharma Medica, Mar. 2020

  
• 【シングルセルゲノミクス 組織の機能、病態が1細胞レベルで見えてきた!】(第2章)シングルセル解析によるバイオロジー 発生・臓器・オルガノイド シングルセルRNA-seqを用いた肺線維症の解析 データベースを用いた具体的な解析方法の紹介

  金墻 周平; 後藤 慎平

  実験医学, Dec. 2019

  
• 呼吸器の修復・再生機序を探る iPS細胞を用いた難治性肺疾患の病態解明

  後藤 慎平

  日本呼吸器学会誌, Mar. 2019

  
• 呼吸器におけるiPS細胞研究

  後藤 慎平

  日本呼吸器学会誌, Mar. 2019

  
• 呼吸器生命科学研究を俯瞰する 薬学・発生生物学・再生医学の融合による疾患治療への応用 ヒトiPS細胞を用いた呼吸器疾患の病態解明

  後藤 慎平

  日本薬学会年会要旨集, Mar. 2019

  
• ヒト多能性幹細胞から呼吸器上皮細胞への分化誘導法の確立

  後藤慎平

  日本医学会総会総会会誌, 2019

  
• 次世代に繋げるCOPDの新知見 COPD治療を目指したヒトiPS細胞の技術

  後藤 慎平

  日本呼吸器学会誌, Mar. 2018

  
• iPS細胞を用いた肺胞オルガノイド長期培養系の確立とその応用

  山本佑樹; 後藤慎平; 後藤慎平; 興梠陽平; 関真秀; 小西聡史; 池尾聡; 曽根尚之; 長崎忠雄; 松本久子; 室繁郎; 伊藤功朗; 平井豊博; 河野隆志; 鈴木穣; 三嶋理晃

  日本再生医療学会総会(Web), 2018

  
• ヒト多能性幹細胞からⅡ型肺胞上皮細胞への分化促進と単離

  後藤 慎平; 三嶋 理晃

  呼吸と循環, Jul. 2015

  
• Generation of Airway Epithelial Cells from Human Induced Pluripotent Stem Cells

  小西 聡史; 後藤 慎平

  呼吸と循環, Aug. 2016

  
• ヒトiPS細胞から気道繊毛上皮前駆細胞への効率の良い分化誘導法の確立

  KONISHI SATOSHI; GOTOH SHIMPEI; YAMAMOTO YUKI; KOROGI YOHEI; NAGASAKI TADAO; MATSUMOTO HISAKO; MURO SHIGEO; HIRAI TOYOHIRO; ITO ISAO; ITO ISAO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2015

  
• 遺伝性呼吸器疾患の疾患特異的iPS細胞樹立

  GOTOH SHIMPEI; ITO ISAO; ITO ISAO; KOROGI YOHEI; YAMAMOTO YUKI; KONISHI SATOSHI; NAGASAKI TADAO; MATSUMOTO HISAKO; SATO ATSUYASU; MURO SHIGEO; HIRAI TOYOHIRO; OSAFUNE KENJI; ASAKA ISAO; SEYAMA KUNIAKI; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2015

  
• ヒトiPS細胞から2型肺胞上皮細胞への分化誘導効率の改善

  YAMAMOTO YUKI; GOTOH SHIMPEI; KOROGI YOHEI; KONISHI SATOSHI; NAGASAKI TADAO; MATSUMOTO HISAKO; MURO SHIGEO; HIRAI TOYOHIRO; ITO ISAO; ITO ISAO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2015

  
• ヒトiPS細胞から肺胞上皮細胞への分化誘導

  後藤慎平; 伊藤功朗; 長崎忠雄; 舩戸道徳; 豊田太郎; 前伸一; 小西聡史; 山本佑樹; 長船健二; 三嶋理晃

  日本呼吸器学会誌, 10 Mar. 2013

  

Presentations

• ヒトiPS細胞を用いた呼吸器再生研究の現状

  後藤慎平

  第1回気道病態研究会, 12 Mar. 2015, Invited

  
• Implementing pluripotent stem cells for human lung disease modeling

  Shimpei Gotoh

  16th US-Japan Symposium on Drug Delivery Systems, 17 Dec. 2024, Invited

  
• 呼吸器の再生医療 ～幹細胞で実現していく肺の再生・疾患モデル～

  ライブセッション in 再生医療 ④, 13 Dec. 2024, Invited

  
• Applications of human pluripotent stem cells to lung disease models

  Shimpei Gotoh

  2nd KU-CMU Joint Symposium, 19 Nov. 2024, Invited

  
• Regenerative medicine for lung diseases

  Shimpei Gotoh

  APSR2024 : Cell and Molecular Biology (2) Updated Molecular Mechanisms on Development of Lung Diseases, 09 Nov. 2024, Invited

  
• Microphysiological system (MPS)を用いたSARS-CoV-2感染モデルの構築と宿主反応の再現

  藤本和也; Sachin Yadev; 亀田良一; 出口清香; 武長徹; 高橋千絵; 村本裕紀子; 三河隆太; 高山和雄; 後藤慎平; 野田岳志; 横川隆司

  第2回新型コロナウイルス研究集会

  
• Modeling of spontaneous pulmonary fibrosis via cellular senescence in type 2 alveolar epithelial cells derived from human iPSCs

  Yusuke Tsutsui; Shimpei Gotoh

  International Society for Stem Cell Research (ISSCR) 2024 Annual Meeting, 10 Jul. 2024

  
• Applications of human pluripotent stem cells to lung regenerative medicine

  Shimpei Gotoh

  Séminaire à l‘Université de Lyon 1, 09 Jul. 2024, Invited

  
• Human iPSC-derived lung epithelial cells in micro-patterned culture distinguish SARS-CoV-2 variant strains

  Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh

  American Thoracic Society 2024, 19 May 2024

  
• Disease modeling of pulmonary alveolar microlithiasis using human induced pluripotent stem cells

  Akira Yamagata; Atsuhi Saito; Satoshi Hamada; Takashi Kawaguchi; Shu Hisata; Akira Niwa; Hirofumi Chiba; Megumu Saito; Koichi Hagiwara; Toyohiro Hirai; Shimpei Gotoh

  American Thoracic Society 2024, 19 May 2024

  
• Screening of multiple signaling pathways converting alveolar type 2 to type 1 cells using human induced pluripotent stem cells

  Yuko Ohnishi; Atsushi Masui; Takahiro Suezawa; Ryuta Mikawa; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  American Thoracic Society 2024, 19 May 2024

  
• ヒトiPS細胞を用いた化合物スクリーニングによる I型肺胞上皮細胞の分化制御因子の探索

  大西裕子; 増井淳; 末澤隆浩; 三河隆太; 平井豊博; 萩原正敏; 後藤慎平

  第64回日本呼吸器学会学術講演会, 05 Apr. 2024

  
• マイクロパターン培養法によるヒトiPS細胞由来呼吸器上皮細胞の分化誘導とSARS-CoV-2感染症モデルへの応用

  増井淳; 橋本里菜; 松村康史; 山本拓也; 長尾美紀; 野田岳志; 高山和雄; 後藤慎平

  第23回日本再生医療学会総会, 21 Mar. 2024

  
• Applications of iPS cells to lung regenerative medicine

  Shimpei Gotoh

  KANSAI DAY / KYOTO DAY, 08 Oct. 2024

  
• 多能性幹細胞のヒト呼吸器発生・ 疾患モデルへの応用

  後藤慎平

  第５回「医学と数理」研究会, 29 Sep. 2024, Invited

  
• 呼吸器の再生医療 ～幹細胞で実現していく肺の再生・疾患モデル～

  後藤慎平

  ライブセッション in 再生医療 ①, 27 Sep. 2024, Invited

  
• iPS細胞を用いた呼吸器臨床応用を目指して

  後藤慎平

  Toyama Respiratory Science and Next Innovation研究会, 20 Sep. 2024, Invited

  
• Disease modeling of intractable lung diseases using iPSCs

  Shimpei Gotoh

  KSSCR 2024 Summer Conference, 29 Aug. 2024, Invited

  
• iPS細胞が可能にする病気の仕組みの解明

  後藤慎平

  すごいぞiPS細胞！〜脳・肺・RNAの研究者は語りたい〜, 28 Jul. 2024

  
• ヒト化呼吸器疾患モデルの構築

  後藤慎平

  第11回天王山免疫カンファレンス, 26 Jul. 2024, Invited

  
• iPS細胞を用いたヒト由来呼吸器組織の再現を目指して

  後藤慎平

  第51回日本毒性学会学術年会 次世代研究セミナー：生体組織を体外で再現する ー 機能の理解とその応用に向けて ー, 04 Jul. 2024, Invited

  
• Lung regenerative medicine toward overcoming pulmonary diseases

  Shimpei Gotoh

  2024年度 大学院教育コース「再生医療・臓器再建医学コース」, 14 Jun. 2024

  
• Applications of lung alveolar organoids derived from human pluripotent stem cells to disease modeling and screening

  Shimpei Gotoh

  The 21st Stem Cell Research Symposium, 24 May 2024, Invited

  
• The Future of Lung Regenerative Medicine: Stem Cell to Organ

  後藤慎平

  第64回日本呼吸器学会学術講演会 会長特別企画, 06 Apr. 2024, Invited

  
• New Directions of Human Lung Organoid Research

  後藤慎平

  Emerging Talent Symposium, 05 Apr. 2024, Invited

  
• iPS細胞を利用した呼吸器オルガノイドの疾患モデル

  後藤慎平

  第5回がん三次元培養研究会, 28 Feb. 2024, Invited

  
• iPS細胞で見えてきた呼吸器の難病・再生医療の未来

  後藤慎平

  令和5年度NHO近畿中央呼吸器センター学術講演会, 16 Feb. 2024, Invited

  
• iPS細胞で立ち向かう呼吸器の難病

  後藤慎平

  京都大学丸ノ内セミナー, 02 Feb. 2024

  
• Organoid and Clinical Key Pathogenesis in the Lung-Fibrosis

  Shimpei Gotoh

  KSSCR 2024 Winter Conference, 04 Jan. 2024, Invited

  
• 難治性呼吸器疾患の克服に向けたiPS細胞の応用

  後藤慎平

  公開シンポジウム 形質発現制御から形態形成機構学、さらに未来へつなぐ, 11 Dec. 2023, Invited

  
• Implementation of iPS cells for lung disease modeling

  Shimpei Gotoh

  PneumoScience Research Lab Seminar at Leiden University, 05 Dec. 2023, Invited

  
• Screening of chemical inducers of alveolar type 1 epithelial cells using human pluripotent stem cells

  Yuko Ohnishi; Atsushi Masui; Ryuta Mikawa; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  CiRA 2023 International Symposium, 30 Nov. 2023

  
• Human iPSC-derived alveolar and airway cells can distinguish SARS-CoV-2 variants

  Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh

  CiRA 2023 International Symposium, 30 Nov. 2023

  
• 化合物スクリーニングを用いた呼吸器疾患研究

  後藤慎平

  京都大学BINDS合同シンポジウム オープンイノベーションから創薬へ ～2023～, 25 Oct. 2023, Invited

  
• iPS細胞による気道疾患モデルの開発と診断・治療への応用

  後藤慎平

  第62回日本鼻科学会総会・学術講演会, 29 Sep. 2023, Invited

  
• iPS細胞を用いた呼吸器疾患モデルのニューパラダイム

  後藤慎平

  日本組織培養学会 第95回大会, 31 Aug. 2023, Invited

  
• iPS細胞を用いた肺胞オルガノイドの開発と疾患モデリング

  後藤慎平

  日本リウマチ学会近畿支部学術集会, 26 Aug. 2023, Invited

  
• iPS細胞を用いて難治性呼吸器疾患の治療を目指す

  後藤慎平

  順天堂大学医学部 若手研究者コミュニティー 研究会, 07 Aug. 2023, Invited

  
• iPS細胞を用いた呼吸器研究の実用化に向けて

  後藤慎平

  第16回iPS細胞産学合同研究会, 03 Jul. 2023, Invited

  
• Identification of factors converting alveolar type 2 to type 1 cells using human iPS cells

  Yuko Ohnishi; Atsushi Masui; Shimpei Gotoh

  International Society for Stem Cell Research Annual Meeting

  
• ヒトiPS細胞由来 呼吸器上皮細胞を用いたSARS-CoV-2 変異株評価系の構築

  増井淳; 橋本里菜; 高山和雄; 後藤槙平

  第1回新型コロナウイルス研究集会, 09 Jun. 2023

  
• 基礎研究の現状と展望

  後藤慎平

  第63回日本呼吸器学会学術講演会 会長特別企画「希少肺疾患・難病の未来に向けた取り組み」, 30 Apr. 2023, Invited

  
• 肺オルガノイド研究の新たな展開

  後藤慎平

  第63回日本呼吸器学会学術講演会 教育講演, 29 Apr. 2023, Invited

  
• Generation and application of iPSC-derived mesenchymal cell-dependent alveolar organoids

  Tamai K; Sakai K; Yamaki H; Moriguchi K; Igura K; Maehana S; Suezawa T; Takehara K; Hagiwara M; Hirai T; Gotoh S

  2023 RIKEN BDR-CuSTOM Joint Organoid Symposium, 15 Feb. 2023

  
• 肺胞オルガノイドを分化誘導可能なヒトiPS細胞由来間葉細胞の開発と感染症モデルへの応用

  玉井浩二; 酒井宏治; 山城春華; 森口啓太; 伊倉宏一; 前花祥太郎; 末澤隆浩; 竹原一明; 萩原正敏; 平井豊博; 後藤慎平

  第45回日本分子生物学会年会, 30 Nov. 2022

  
• 呼吸器臨床への橋渡しを目指して

  後藤 慎平

  第13回令和私塾, 08 Nov. 2022, Invited

  
• 難治性呼吸器疾患の克服に向けて

  後藤 慎平

  医学研究支援センター10周年記念セミナー（第10回）, 26 Oct. 2022, Invited

  
• From in vitro to in vivo generation of human lung models using iPS cells

  Shimpei Gotoh

  第６回ヒト化マウス国際ワークショップ, 12 Oct. 2022, Invited

  
• ACE2 knockout hinders SARS-CoV-2 propagation in iPSC-derived airway and alveolar epithelial cells

  Niwa R; Sakai K; Lung M; Matsumoto T; Mikawa R; Takahashi S; Yamamoto Y; Kanamune J; Moteki Y; Oceguera-Yanez J; Maurissen T; Maehana S; Takehara K; Gotoh S; Woltjen K

  日本ゲノム編集学会第7回大会, 08 Jun. 2022

  
• DERIVATION OF LUNG DISTAL TIP MESENCHYMAL CELLS FROM HUMAN PLURIPOTENT STEM CELLS

  Tamai K; Sakai K; Haruka Yamaki; Moriguchi K; Igura K; Maehana S; Suezawa T; Takehara K; Hagiawara M; Hirai Y; Gotoh S

  International Society for Stem Cell Research Annual Meeting, Jun. 2022

  
• ヒトiPS 細胞を用いた呼吸器上皮細胞への分化誘導技術と細胞ファイバ技術を融合した新たな培養メソッドで切り開く肺再生研究の未来

  池尾聡; 山本佑樹; 池田和弘; 曽根尚之; 興梠陽平; 平井豊博; 後藤慎平

  第61回日本呼吸器学会学術講演会, 22 Apr. 2022

  
• Disease modeling of primary ciliary dyskinesia using human iPS cells

  後藤慎平

  第127回日本解剖学会総会・全国学術集会(Web開催) シンポジウム ユビキタス化する繊毛研究 の可能性：ヒト疾患の病態生理解明からその先へ, 19 Mar. 2022, Invited

  
• iPS細胞を用いて肺を再構築する

  後藤 慎平

  令和３年度AMED再生・細胞医療・遺伝子治療公開シンポジウム, 01 Feb. 2022

  
• iPS細胞からの肺胞上皮細胞再生

  後藤 慎平

  日本肺サーファクタント・界面医学会57回学術研究会, 15 Jan. 2022, Invited

  
• The iPS cells for emulating human lung in vitro

  Shimpei Gotoh

  Virtual workshop by NIH-NHLBI, 16 Dec. 2021, Invited

  
• The iPS cells for human lung diseases, now and the future

  Shimpei Gotoh

  Virtual mini symposium on Cilia and Gene Therapy, Brunel University, 15 Nov. 2021, Invited

  
• 病態 変異株は重症化するのか？

  第61回日本呼吸器学会学術講演会 緊急特別プログラム 「COVID-19診療における現場の疑問点を考察する ～呼吸器学会FAQ広場に寄せられた質問を中心に」～, 23 Apr. 2021

  
• ヒトiPS細胞を用いた疾患モデル開発

  第61回日本呼吸器学会学術講演会 シンポジウム「肺のバイオエンジニアリング/オルガノイド研究」, 23 Apr. 2021, Invited

  
• iPS細胞を用いた疾患モデリング

  第5回肺トランスレーショナルメディシン研究会 『II型肺胞上皮細胞の分化と機能』, 23 Mar. 2021, Invited

  
• ヒト多能性幹細胞から分化誘導した気道・肺胞オルガノイドの応用

  第20回日本再生医療学会総会 シンポジウム15 再生医療におけるオルガノイド・発生学研究の新展開, 12 Mar. 2021

  
• New findings of human iPS cell-derived airway and alveolar epithelial cells

  Marsico Seminar Series (Webinar), The University of North Carolina at Chapel Hill

  11 Dec. 2020, Invited

  
• Applications of human pluripotent stem cells to lung research

  後藤慎平

  理化学研究所IMSセミナー (Web開催), 30 Oct. 2020, Invited

  
• 分子生物学的視点からみたCOVID-19肺炎の病態 —重症化のメカニズム—

  後藤慎平

  第60回日本呼吸器学会学術講演会 緊急企画「新型コロナ感染症について」, 20 Sep. 2020

  
• Human iPS cell-derived alveolar type I cells defined by single cell RNA-seq

  後藤慎平

  第60回日本呼吸器学会学術講演会 シンポジウム「呼吸器疾患の克服に向けて」, 20 Sep. 2020, Invited

  
• ヒトiPS 細胞から作る肺細胞はどう役立つか？現状と今後の展望について

  後藤慎平

  Web-Scientific Exchange Meeting in Sapporo, 02 Sep. 2020, Invited

  
• 難治性呼吸器疾患の克服を目指したiPS細胞の利活用

  後藤慎平

  第69回浜松呼吸器セミナー, 03 Feb. 2020, Invited

  
• Combination of iPS cells and airway-on-a-chip for disease modeling of primary ciliary dyskinesia.

  Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Yamamoto Y, Hirai T, Torisawa Y, Gotoh S.

  CiRA 2019 International Symposium, Nov. 2019

  
• Applications of iPS cells to pulmonology

  Shimpei Gotoh

  第72回日本胸部外科学会 定期学術集会,, 31 Oct. 2019, Invited

  
• Elucidating the secrets of human lung by using iPS cells

  Shimpei Gotoh

  第15回再生医療・臓器再建医学コース リトリート, 19 Oct. 2019, Invited

  
• ヒトiPS細胞から見えてきた呼吸器研究の新展開

  後藤慎平

  奈良県立医科大学 特別講演会, 25 Sep. 2019, Invited

  
• Ciliated iPS cells in vitro "PCD modeling by using human iPS cells"

  Shimpei Gotoh

  PCD on the Move 2019!, 21 Aug. 2019, Invited

  
• iPS細胞を呼吸器にどう役立てるか

  後藤慎平

  第6回東京Asthma & COPD研究会, 02 Aug. 2019, Invited

  
• iPS細胞を用いた肺オルガノイドからの呼吸器疾患モデリング

  後藤慎平

  千里ライフサイエンスセミナーN2, 24 Jul. 2019, Invited

  
• Derivation of functional alveolar & airway cells & their applications to disease modeling

  Shimpei Gotoh

  Columbia Center for Human Development seminar series, 19 Jul. 2019, Invited

  
• Applications of hiPSCs to Airway and Alveolar Disease Modeling

  Shimpei Gotoh

  Stem Cells, Cell Therapies, and Bioengineering In Lung Biology and Diseases Conference, 16 Jul. 2019, Invited

  
• Assessment of bipotency of expanded human induced pluripotent stem cell-derived nkx2.1+ lung progenitor cells to be differentiate into both airway and alveolar epithelial cells.

  Ikeo S, Gotoh S, Korogi Y, Sone S, Tamai K, Konishi S, Yamamoto Y, Hirai T.

  International Society for Stem Cell Research 16th Annual Meeting, Jun. 2019

  
• Applications of functional lung epithelial cells derived from human pluripotent stem cells.

  Shimpei Gotoh

  American Thoracic Society symposium (ATS2019), 19 May 2019, Invited

  
• Recapitulating functional lung cells by using human iPS cells

  Shimpei Gotoh

  第59回日本呼吸器学会学術講演会, 13 Apr. 2019

  
• iPS細胞を用いた難治性肺疾患の病態解明

  後藤 慎平

  第59回日本呼吸器学会学術講演会, 13 Apr. 2019

  
• 呼吸器におけるiPS細胞研究

  後藤 慎平

  第59回日本呼吸器学会学術講演会 教育講演, 12 Apr. 2019, Invited

  
• ヒトiPS細胞を用いた原発性繊毛機能不全症の疾患モデリング

  曽根 尚之; 後藤 慎平; 小西 聡史; 玉井 浩二; 池尾 聡; 興梠 陽平; 伊倉 宏一; 平井 豊博

  第38回気道分泌研究会, 06 Apr. 2019

  
• ヒトiPS細胞を用いた呼吸器疾患の病態解明

  後藤 慎平

  第139回日本薬学会年会, 21 Mar. 2019, Invited

  
• Characterization of human alveolar cells derived from HPS2 patient-derived ips cells

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Isao Asaka; Akitsu Hotta; Toyohiro Hirai

  Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference, 19 Feb. 2019

  
• Generation and applications of human iPS cell-derived lung epithelial cells.

  Shimpei Gotoh

  23rd Congress of the Asian Pacific Society of Respirology, 30 Nov. 2018, Invited

  
• Application of human iPS cell technologies for lung research.

  Shimpei Gotoh

  第54回日本肺サーファクタント・界面医学会, 27 Oct. 2018, Invited

  
• Recapitulating Alveolar Epithelial Type 2 Cell Dysfunction in Hermansky-Pudlak Syndrome Type 2 Patient-derived Induced Pluripotent Stem Cells

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Isao Asaka; Akitsu Hotta; Toyohiro Hirai

  日本肺サーファクタント・界面医学会 第54回学術研究会, 27 Oct. 2018

  
• Transplantation study of human alveolar stem cells derived from iPS cells.

  Yamamoto Y; Gotoh S; Ikeo S; Korogi Y; Sone N; Tamai K; Konishi S; Hirai T

  TERMIS World Congress, Kyoto stem cells derived from iPS cells., 07 Sep. 2018

  
• Disease modeling of primary ciliary dyskinesia using human induced pluripotent stem cells.

  Sone N; Gotoh S; Konishi S; Tamai K; Ikeo S; Korogi Y; Igura K; Hirai T

  International Society for Stem Cell Research 16th Annual Meeting, Jun. 2018

  
• Human lung organoids in vivo using iPS cell-derived alveolar epithelial type 2 cells.

  Yuki Yamamoto; Shimpei Gotoh; Satoshi Ikeo; Yohei Korogi; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Toyohiro Hirai

  American Thoracic Society symposium (ATS2018), 21 May 2018

  
• COPD治療を目指したヒトiPS細胞の技術

  後藤 慎平

  第58回日本呼吸器学会学術講演会 若手企画, Apr. 2018

  
• Applications of human pluripotent stem cells for lung research

  Shimpei Gotoh

  第58回日本呼吸器学会学術講演会 呼吸器領域 若手シンポジウム, Apr. 2018

  
• Induction of functional lung epithelial cells from human pluripotent stem cells

  Shimpei Gotoh

  第95回日本生理学会大会, 29 Mar. 2018, Invited

  
• シングルセル解析で⾒えてきたin vitro 分化の不均⼀性と整合性 〜呼吸器を例に〜

  後藤 慎平

  第17回再生医療学会総会, 23 Mar. 2018, Invited

  
• 新規抗CPM抗体を用いたヒトiPS細胞からの呼吸器上皮細胞の分化誘導

  池尾 聡; 後藤 慎平; 辻 貴宏; 山本 佑樹; 興梠 陽平; 小西 聡史; 曽根 尚之; 玉井 浩二; 竹田 康弘; 上村 光宏; 小笹 裕晃; 平井 豊博

  第17回日本再生医療学会総会, 22 Mar. 2018

  
• iPS細胞を用いた肺胞オルガノイド長期培養系の確立とその応用

  山本 佑樹; 後藤 慎平; 興梠 陽平; 関 真秀; 小西 聡史; 池尾 聡; 曽根 尚之; 長崎 忠雄; 松本 久子; 室 繁郎; 伊藤 功朗; 平井 豊博; 河野 隆志; 鈴木 穣; 三嶋 理晃

  第17回日本再生医療学会総会, 22 Mar. 2018

  
• ヒト多能性幹細胞由来の呼吸器上皮細胞の有用性

  後藤 慎平

  第40回日本分子生物学会年会, Dec. 2017

  
• In vitro disease modeling of alveolar phenotype caused by AP3B1 deficiency using human induced pluripotent stem cells.

  Korogi Y; Gotoh S; Yamamoto Y; Konishi S; Nagasaki T; Sone N; Ikeo S; Matsumoto H; Muro S; Ito I; Asaka I; Hotta A; Hirai T

  International Society for Stem Cell Research 15th Annual Meeting, Jun. 2017

  
• ヒトiPS細胞を用いた呼吸器研究の現状と今後の可能性

  後藤 慎平

  第36回気道分泌研究会, 08 Apr. 2017, Invited

  
• ヒトiPS細胞の呼吸器領域への応用

  後藤 慎平

  第16回日本再生医療学会総会, 08 Mar. 2017

  
• ヒトiPS細胞を用いた呼吸器研究の現状と今後の展望

  後藤 慎平

  第34回 KUMAMOTO Repiratory & Critical Care Medicine seminar, 03 Mar. 2017, Invited

  
• ヒトiPS細胞を用いた呼吸器再生研究の新展開

  後藤 慎平

  第15回京大病院iPS細胞・再生医学研究会, 19 Jan. 2017, Invited

  
• ヒト多能性幹細胞から分化した気道繊毛上皮の有用性

  後藤 慎平

  第39回 日本分子生物学会年会, Dec. 2016

  
• ヒトiPS細胞の呼吸器研究への応用

  後藤 慎平

  第29回 日本動物実験代替法学会, Nov. 2016

  
• ヒトiPS細胞を用いた呼吸器研究と今後の展望

  後藤 慎平

  愛媛医療センター臨床研究部講演会, 07 Jul. 2016, Invited

  
• Long-term culture of alveolar epithelial type 2 cells derived from human induced pluripotent stem cells.

  Yamamoto Y; Gotoh S; Korogi Y; Konishi S; Nagasaki T; Matsumoto H; Muro S; Hirai T; Ito I; Mishima M

  International Society for Stem Cell Research 14th Annual Meeting, Jun. 2016

  
• ヒトiPS細胞から呼吸器上皮細胞への分化誘導技術

  後藤 慎平

  第56回日本呼吸器学会学術講演会シンポジウム「呼吸器疾患解析・治療応用が期待されるテクノロジー」, 10 Apr. 2016, Invited

  
• Directed induction of functional multi-ciliated airway epithelial cells from human pluripotent stem cells.

  Konishi S; Gotoh S; Tateishi K; Yamamoto Y; Korogi Y; Nagasaki T; Matsumoto H; Muro S; Hirai H; Ito I; Tsukita S; Mishima M

  CiRA/ISSCR 2016 International Symposium, Mar. 2016

  
• ヒトiPS細胞を用いた呼吸器再生研究の現状と今後の課題

  後藤 慎平

  第266回 宮城県立がんセンターセミナー, 23 Oct. 2015, Invited

  
• Generation of ciliated airway epithelial cells from human induced pluripotent stem cells

  Konishi S; Gotoh S; Yamamoto Y; Korogi Y; Nagasaki T; Matsumoto H; Muro S; Hirai H; Ito I; Mishima M

  International Society for Stem Cell Research 13th Annual Meeting, Stockholm, Jun. 2015

  
• Generation of alveolar epithelial cells from human pluripotent stem cells

  Gotoh S; Ito I; Nagasaki T; Yamamoto Y; Konishi S; Korogi Y; Matsumoto H; Muro S; Hirai T; Funato M; Mae S; Toyoda T; Sato-Otsubo A; Ogawa S; Osafune K; Mishima M

  International Society for Stem Cell Research 12th Annual Meeting, Vancouver, Jun. 2014

  
• ヒトiPS細胞からⅡ型肺胞上皮細胞への分化誘導効率の改善

  後藤 慎平

  第54回 日本呼吸器学会学術講演会, 2014

  
• ヒトiPS細胞から気道繊毛上皮前駆細胞への効率の良い分化誘導法の確立

  小西聡史; 後藤慎平; 山本佑樹; 興梠陽平; 長崎忠雄; 松本久子; 室繁郎; 平井豊博; 伊藤功朗; 三嶋理晃

  第54回 日本呼吸器学会学術講演会, 2014

  
• 遺伝性呼吸器疾患の疾患特異的iPS細胞樹立

  後藤慎平; 伊藤功朗; 長崎忠雄; 舩戸道徳; 豊田太郎; 前伸一; 小西聡史; 山本佑樹; 三嶋理晃

  第53回 日本呼吸器学会学術講演会, 2014

  
• ヒトiPS細胞を用いた呼吸器再生研究

  後藤 慎平

  第7回京大病院iPS細胞・再生医学研究会, 25 Jan. 2013, Invited

  
• 市中肺炎における相対的副腎不全についての検討

  後藤慎平; 西村直樹; 高橋理; 白塚秀之; 内山伸; 上田宏隆; 蝶名林直彦

  第47回 日本呼吸器学会学術講演会, 2007

  
• タイトジャンクションストランド形成におけるPDZ含有裏打ち蛋白質の役割

  後藤慎平; 古瀬京子; 佐々木博之; 古瀬幹夫; 月田承一郎

  第25回日本分子生物学会, 2002

  

Books and Other Publications

• 肺HRCT 原著5版

  W. Richard Webb; Nestor L. Müller; David P Naidich, Joint translation, 過敏性肺炎、好酸球性肺疾患、肺高血圧症、肺血管疾患

  丸善株式会社, Apr. 2016, Not refereed

  
• HIGH RESOLUTION CT of the LUNG

  W. Richard Webb; Nestor L. Müller; David P Naidich, Joint translation, 肺気腫、肺高血圧症、肺血管疾患

  Lippincott Williams & Wilkins /Wolters Kluwer Health, Apr. 2010, Not refereed

  

Industrial Property Rights

• 特許第6461787号, WO2014-168264, 特願2015-511329, 肺胞上皮前駆細胞の誘導方法

  長船 健二; 後藤 慎平; 伊藤 功朗; 三嶋 理晃

  
• 特許第6738572号, WO2016-143803, 特願2015-045298, 肺胞上皮細胞の分化誘導法

  後藤慎平; 山本佑樹; 小西聡史; 三嶋理晃

  
• 特許第6730709号, WO2016-148307, 特願2015-056791, 気道上皮細胞の分化誘導法

  後藤慎平; 小西聡史; 山本佑樹; 三嶋理晃

  

Awards

• 01 Dec. 2023

  ベルツ賞(2等)
• 18 Jun. 2014

  The International Society for Stem Cell Research, ISSCR 12th Annual Meeting, Travel Award
• 2015

  Faculty of Medicine, Kyoto University, Kyoto University Medical Student Support-Fund Young Investigator Award
• 2015

  NPO法人西日本呼吸器内科医療推進機構, NPO法人西日本呼吸器内科医療推進機構 研究部門奨励賞
• 2019

  Japanese Repiratory Society, 日本呼吸器学会奨励賞
• 2019

  日本医学会, 日本医学会総会奨励賞

External funds: Kakenhi

• 肺オルガノイドを用いた呼吸器病原体の革新的研究基盤の構築と病原性発現機序の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 54030:Infectious disease medicine-related

  National Institute of Infectious Diseases

  酒井 宏治

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  SARS-CoV-2;インフルエンザウイルス;iPS細胞;ACE2;TMPRSS2;肺オルガノイド;ゲノム編集

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02973/
• Identification of the gene responsible for pulmonary fibrosis, and exploration about the association between cell death and fibrosis through the disease-derived iPS cell-differentiated lung cells

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53030:Respiratory medicine-related

  Tokyo Medical and Dental University

  瀬戸口 靖弘

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  肺線維化;サーファクタント蛋白遺伝子;エクソーム解析;細胞老化;細胞死;遺伝子;iPS細胞;家族性間質性肺炎;サーファクタント;テロメア;エクソーム;iPS;線維性間質性肺炎;小胞体ストレス;網羅的エクソーム解析;サーファクタント関連遺伝子;ネクロトーシス;RNA sequence;線維性間質生肺炎;遺伝子変異;apoptosis;necroptosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03687/
• Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Teikyo University;Osaka University

  月田 早智子

  From 23 Apr. 2019, To 31 Mar. 2024, Granted

  上皮バリア;タイトジャンクション;クローディン;上皮細胞;細胞骨格;アピカル膜;アピカル骨格;クライオ電顕;TJストランド;細胞間バリア;TJ-アピカル複合体;アピカル細胞骨格;TJ-ストランド;TJ-MAPs

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H05468/
• Analysis of the pathogenesis of acute respiratory viral infections.

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42020:Veterinary medical science-related

  National Institute of Infectious Diseases

  Kouji Sakai

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  急性呼吸器ウイルス;ウイルス膜蛋白質;開裂;宿主プロテアーゼ;病原性;インフエンザウイルス;パラミクソウイルス;インフルエンザウイルス;Tmprss2;膜蛋白質の開裂;肺オルガノイド;センダイウイルス;TMPRSS2;宿主域

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02352/
• The establishment of intercellular co-ordination of ciliary movement by using human iPS cell-derived airway epithelial cells

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Satoshi Konishi

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  多繊毛協調運動;粘液繊毛クリアランス;気道疾患モデリング;ヒトiPS細胞;初代培養マウス気管上皮細胞;ライブセルイメージング;気道繊毛上皮細胞;超解像顕微鏡;平面極性コア蛋白;アピカル細胞骨格;疾患モデルiPS細胞;繊毛上皮細胞;気道上皮細胞;細胞間の繊毛協調運動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K17853/
• Generation of the methods of safety evaluation for alveolar organoid transplantation

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Shimpei Gotoh

  From 01 Apr. 2017, To 31 Mar. 2021, Project Closed

  肺;ヒトiPS細胞;移植;オルガノイド;肺胞;iPS細胞;再生医学;細胞・組織

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H05084/
• Expanding human iPS cell-derived alveolar type II cells and their application to disease modeling of hereditary pulmonary fibrosis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Shimpei Gotoh

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  再生医学;iPS細胞;呼吸器;肺線維症;II型肺胞上皮細胞;分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21114/
• Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mishima Michiaki

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  分子細胞呼吸学;iPS細胞;肺臓器再生;疾患モデリング;分子細胞呼吸器学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02537/
• iPS細胞を用いた難治性気管支拡張症の新規診断法の確立と治療法の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  後藤 慎平

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  難治性気管支拡張症;遺伝性疾患;線毛;治療モデル;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03077/
• Functional replacement of mouse lungs by human-derived lung cells

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 53:Organ-based internal medicine and related fields

  Kyoto University

  後藤 慎平

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  肺胞上皮細胞;移植;呼吸器;肺;再生;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19525/
• iPS細胞を用いた難治性気管支拡張症の新規診断法の確立と治療法の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  後藤 慎平

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  難治性気管支拡張症;遺伝性疾患;線毛;治療モデル;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24338/

External funds: others

• iPS細胞を用いたヒトII型肺胞上皮細胞の分化増殖の機序の解明と創薬への応用

  平成27年度 かなえ医薬振興財団研究助成金

  From 01 Feb. 2016, To 31 Mar. 2017

  後藤慎平
• ヒトiPS細胞を用いた肺ヒト化マウスと難治性呼吸器疾患に対する細胞治療法の開発

  平成27年度 京都大学医学部附属病院臨床研究総合センター研究助成

  From 01 Apr. 2015, To 31 Mar. 2016

  後藤慎平
• ヒトiPS細胞から気道繊毛上皮細胞を作成するキットの開発

  平成27年度 京都市 京都発革新的医療技術研究開発助成

  From 01 Jun. 2015, To 29 Feb. 2016

  後藤慎平
• ヒトiPS細胞から気道・肺胞上皮細胞への分化誘導法の改良と遺伝性肺線維症治療 薬の開発

  平成26年度 京都大学医学部附属病院臨床研究総合センター研究助成・追加支援

  From 19 Dec. 2014, To 31 Mar. 2015

  後藤慎平

Education

Participation in PhD Defense

• Synthetic circular RNA switches and circuits that control protein expression in mammalian cells

  KAMEDA SHIGETOSHI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma

  TERADA KAZUHIRO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Intermittent Ex Vivo Lung Perfusion in a Porcine　Model for Prolonged Lung Preservation

  SAKANOUE ICHIRO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids

  Yu Tian, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Development of novel layered polyglycolic acid sheet for regeneration of critical-size defect in rat trachea

  MURATA YOSHITAKE, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Local coordination of epithelial planar polarity in the maintenance and regeneration of the adult rat airway

  OYAGI SEIJI, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• A novel cell-based assay for the high-throughput screening of epithelial-mesenchymal transition inhibitors: Identification of approved and investigational drugs that inhibit epithelial-mesenchymal transition

  ISHIKAWA HIROYUKI, Graduate School of Medicine, Chief Examiner

  25 Sep. 2023
• Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes

  NOMURA NATSUKO, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

  ABE KENGO, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• Yes-associated protein 1 mediates initial cell survival during lorlatinib treatment through AKT signaling in ROS1-rearranged lung cancer

  YAMAZOE MASATOSHI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Transplantation of Induced Pluripotent Stem Cell-Derived Airway Epithelia with a Collagen Scaffold into the Nasal Cavity

  KITADA YUJI, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Nucleome programming is required for the foundation of totipotency in mammalian germline development

  NAGANO MASAHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Lung fibrogenic microenvironment in mouse reconstitutes human alveolar structure and lung tumor

  MIYATA RYO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Deletion of IKKβ in activated fibroblasts promotes tumor progression in melanoma

  ZHANG SHUANG, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023

Administration

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  人権委員会1号委員
• From 01 Apr. 2024, To 31 Mar. 2026

  安全衛生委員会5号委員
• From 01 Apr. 2024, To 31 Mar. 2026

  化学物質管理委員会委員長、1号委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科運営委員会