Basic Information

Faculty

• 理学部

Professional Memberships

• 日本薬学会
• 有機合成化学協会
• アメリカ化学会(American Chemical Society)
• 日本化学会

Academic Degree

• ＰＨ．Ｄ（ＣＨＥＭＩＳＴＲＹ）(ハワイ大学)

Academic Resume (Graduate Schools)

• ハワイ大学, 大学院博士課程化学科, 単位修得

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部, 卒業

Language of Instruction

• English

ID,URL

• J-Global ID

  200901002203619805

researchmap URL

• https://researchmap.jp/read0011285

Research

Research Topics, Overview of the research

• Research Topics

  Development of Organocatalytic Chemistry

• Overview of the research

  The environmentally-benign organocatalysis has recently emerged as a field of research providing practical alternative or complementary technologies to the more traditional transition metal catalyzed systems. Accordingly, Maruoka has rationally designed various environmentally-benign chiral organocatalysts, and some of them are found to be quite useful in a practical manner for the development of environmentally-benign asymmetric organic transformations. For example, Nagase Co. Ltd. utilizes Simplified Maruoka Catalyst® for the large-scale production (up to several hundred kilograms) of artificial amino acids for preparing pharmaceutically important starting materials and intermediates.

Research Interests

• 合成化学
• Synthetic Chemistry

Research Areas

• Nanotechnology/Materials, Synthetic organic chemistry
• Life sciences, Bioorganic chemistry
• Nanotechnology/Materials, Structural/physical organic chemistry

Papers

• The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(iii) reagents

  Sakamoto Ryu; Hirama Naomichi; Maruoka Keiji

  ORGANIC & BIOMOLECULAR CHEMISTRY, 14 Aug. 2018, Peer-reviewed

  
• BF3-Catalyzed Synthesis of Cyclic Carbamates from Boc-Protected Aminals and Alkynes

  Kano Taichi; Yasumoto Kento; Maruoka Keiji

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Aug. 2018, Peer-reviewed

  
• Synthesis of 1-Aminoindenes through Aza-Prins-Type Cyclization

  Bai Jian-Fei; Yasumoto Kento; Kano Taichi; Maruoka Keiji

  CHEMISTRY-A EUROPEAN JOURNAL, 20 Jul. 2018, Peer-reviewed

  
• Enantioselective Alkylation of N-Arylhydrazones Derived from -Keto Esters and Isatin Derivatives through Asymmetric Phase-Transfer Catalysis

  Kang Qi-Kai; Selvakumar Sermadurai; Arumugam Natarajan; Almansour Abdulrahman I; Kumar Raju Suresh; Maruoka Keiji

  CHEMISTRY-AN ASIAN JOURNAL, 16 Jul. 2018, Peer-reviewed

  
• Phase-transfer-catalysed asymmetric synthesis of 2,2-disubstituted 1,4-benzoxazin-3-ones

  Pawliczek Martin; Shimazaki Yuto; Kimura Hidenori; Oberg Kevin M; Zakpur Saman; Hashimoto Takuya; Maruoka Keiji

  CHEMICAL COMMUNICATIONS, 28 Jun. 2018, Peer-reviewed

  
• Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization

  Takuya Hashimoto; Yuto Shimazaki; Yamato Omatsu; Keiji Maruoka

  Angewandte Chemie - International Edition, 11 Jun. 2018, Peer-reviewed

  
• Transition-Metal-Free Direct C−H Silylation of Electron-Deficient Heteroarenes with Hydrosilanes via a Radical Mechanism

  Ryu Sakamoto; Bich-Ngoc Nguyen; Keiji Maruoka

  Asian Journal of Organic Chemistry, 01 Jun. 2018, Peer-reviewed

  
• Catalyst-controlled diastereoselectivity reversal in the formation of dihydropyrans

  Taichi Kano; Hiroki Maruyama; Chihiro Homma; Keiji Maruoka

  Chemical Communications, 11 Apr. 2018, Peer-reviewed

  
• A Synthetic Route to Sodium α-Aminoalkanesulfinates and Their Application in the Generation of α-Aminoalkyl Radicals for Radical Addition Reactions

  Ryu Sakamoto; Tomomi Yoshii; Hiroyuki Takada; Keiji Maruoka

  Organic Letters, 06 Apr. 2018, Peer-reviewed

  
• Copper-Catalyzed C(sp)-C(sp3) Coupling of Terminal Alkynes with Alkylsilyl Peroxides via a Radical Mechanism

  Ryu Sakamoto; Terumasa Kato; Shunya Sakurai; Keiji Maruoka

  Organic Letters, 02 Mar. 2018, Peer-reviewed

  
• Alkylative kinetic resolution of vicinal diols under phase-transfer conditions: A chiral ammonium borinate catalysis

  Martin Pawliczek; Takuya Hashimoto; Keiji Maruoka

  Chemical Science, 2018, Peer-reviewed

  
• Asymmetric Synthesis of Less Accessible α-Tertiary Amines from Alkynyl Z-Ketimines

  Taichi Kano; Yusuke Aota; Keiji Maruoka

  Angewandte Chemie - International Edition, 18 Dec. 2017, Peer-reviewed

  
• Synthesis of Chiral Tritylpyrrolidine Derivatives and Their Application to Asymmetric Benzoyloxylation

  Mio Shimogaki; Hiroki Maruyama; Shingo Tsuji; Chihiro Homma; Taichi Kano; Keiji Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, Dec. 2017, Peer-reviewed

  
• Hypervalent Iodine Mediated Chemoselective Iodination of Alkynes

  Yan Liu; Daya Huang; Ju Huang; Keiji Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, Nov. 2017, Peer-reviewed

  
• The Direct C-H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands

  Ryu Sakamoto; Hirotaka Kashiwagi; Keiji Maruoka

  ORGANIC LETTERS, Oct. 2017, Peer-reviewed

  
• Hypervalent iodine(III) catalyzed radical hydroacylation of chiral alkylidenemalonates with aliphatic aldehydes under photolysis

  Sermadurai Selvakumar; Qi-Kai Kang; Natarajan Arumugam; Abdulrahman I. Almansour; Raju Suresh Kumar; Keiji Maruoka

  TETRAHEDRON, Oct. 2017, Peer-reviewed

  
• Practical Synthesis of both Enantiomeric Amino Acid, Mannich, and Aldol Derivatives by Asymmetric Organocatalysis

  Yan Liu; Natarajan Arumugam; Abdulrahman I. Almansour; Raju Suresh Kumar; Keiji Maruoka

  CHEMICAL RECORD, Oct. 2017, Peer-reviewed

  
• Practical Synthesis of Two Different Pseudoenantiomeric Organocatalysts with cis-Cyclohexanediamine Structure from a Common Chiral Source

  Hyo-Jun Lee; Shin A. Moteki; Natarajan Arumugam; Abdulrahman I. Almansour; Raju Suresh Kumar; Yan Liu; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Sep. 2017, Peer-reviewed

  
• Catalyst-Controlled, Enantioselective, and Diastereodivergent Conjugate Addition of Aldehydes to Electron-Deficient Olefins

  S. B. Jennifer Kan; Hiroki Maruyama; Matsujiro Akakura; Taichi Kano; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Aug. 2017, Peer-reviewed

  
• SERS detection and analysis of a single DNA oligomer using a single gold nanoparticle dimer

  Katsunari Maruoka; Koji Sugano; Yoshitada Isono

  TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, 26 Jul. 2017, Peer-reviewed

  
• Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines

  Ryu Sakamoto; Shunya Sakurai; Keiji Maruoka

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2017, Peer-reviewed

  
• In situ generation of N-Boc-protected alkenyl imines: controlling the E/Z geometry of alkenyl moieties in the Mukaiyama-Mannich reaction

  Jian-Fei Bai; Hajime Sasagawa; Taiga Yurino; Taichi Kano; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, Jul. 2017, Peer-reviewed

  
• In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

  Taichi Kano; Chihiro Homma; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, Jun. 2017, Peer-reviewed

  
• Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides

  Ryu Sakamoto; Shunya Sakurai; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, Jun. 2017, Peer-reviewed

  
• Phase-transfer catalyzed asymmetric synthesis of alpha,beta-unsaturated gamma,gamma-disubstituted gamma-lactams

  Alexander Arlt; Hideaki Toyama; Koji Takada; Takuya Hashimoto; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, May 2017, Peer-reviewed

  
• Chiral Tertiary Sulfonium Salts as Effective Catalysts for Asymmetric Base-Free Neutral Phase-Transfer Reactions

  Shiyao Liu; Keiji Maruoka; Seiji Shirakawa

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Apr. 2017, Peer-reviewed

  
• Synthesis of the Right-Side Structure of Type B Physalins

  Masaki Morita; Shuntaro Kojima; Megumi Ohkubo; Hiroyuki Koshino; Daisuke Hashizume; Go Hirai; Keiji Maruoka; Mikiko Sodeoka

  ISRAEL JOURNAL OF CHEMISTRY, Apr. 2017, Peer-reviewed

  
• A New Strategy for Organocatalyzed Asymmetric Synthesis of BINOL Derivatives

  Seiji Shirakawa; Keiji Maruoka

  CHEM, Mar. 2017, Peer-reviewed

  
• Hydrogen-bonding catalysis of sulfonium salts

  Shiho Kaneko; Yusuke Kumatabara; Shoichi Shimizu; Keiji Maruoka; Seiji Shirakawa

  CHEMICAL COMMUNICATIONS, Jan. 2017, Peer-reviewed

  
• Chiral amine-catalyzed asymmetric conjugate addition of aldehydes to α-phenylselenoenones as formal: Z -allylating agents

  Taichi Kano; Hiroki Maruyama; Chihiro Homma; Keiji Maruoka

  Chemical Communications, 2017, Peer-reviewed

  
• The design of environmentally-benign, high-performance organocatalysts for asymmetric catalysis

  Ryu Sakamoto; Keiji Maruoka

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2017, Peer-reviewed

  
• [2+2] Photocycloadditions between the Carbon-Nitrogen Double Bonds of Imines and Carbon-Carbon Double Bonds

  Ryu Sakamoto; Tsubasa Inada; Shunya Sakurai; Keiji Maruoka

  ORGANIC LETTERS, Dec. 2016, Peer-reviewed

  
• Aryl Ketone Catalyzed Radical Allylation of C(sp(3))-H Bonds under Photoirradiation

  Shin Kamijo; Kaori Kamijo; Kiyotaka Maruoka; Toshihiro Murafuji

  ORGANIC LETTERS, Dec. 2016, Peer-reviewed

  
• Rate Acceleration of Solid-Liquid Phase-Transfer Catalysis by Rotor-Stator Homogenizer

  Taichi Kano; Yusuke Aota; Keiji Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Sep. 2016, Peer-reviewed

  
• Hydrogen-Bonding Catalysis of Tetraalkylammonium Salts in an Aza-Diels-Alder Reaction

  Yusuke Kumatabara; Shiho Kaneko; Satoshi Nakata; Seiji Shirakawa; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Aug. 2016, Peer-reviewed

  
• Catalytic asymmetric synthesis of axially chiral 2-amino-1,1 '-biaryl compounds by phase-transfer-catalyzed kinetic resolution and desymmetrization

  Seiji Shirakawa; Xiangfei Wu; Shiyao Liu; Keiji Maruoka

  TETRAHEDRON, Aug. 2016, Peer-reviewed

  
• A Bulky Thiyl-Radical Catalyst for the [3+2] Cyclization of N-Tosyl Vinylaziridines and Alkenes

  Takuya Hashimoto; Kohei Takino; Kazuki Hato; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2016, Peer-reviewed

  
• N-Boc-aminals as easily accessible precursors for less accessible N-Boc-imines: facile synthesis of optically active propargylamine derivatives using Mannich-type reactions

  Taiga Yurino; Yusuke Aota; Daisuke Asakawa; Taichi Kano; Keiji Maruoka

  TETRAHEDRON, Jun. 2016, Peer-reviewed

  
• Diastereoselective Radical Hydroacylation of Alkylidenemalonates with Aliphatic Aldehydes Initiated by Photolysis of Hypervalent Iodine(III) Reagents

  Sermadurai Selvakumar; Ryu Sakamoto; Keiji Maruoka

  CHEMISTRY-A EUROPEAN JOURNAL, May 2016, Peer-reviewed

  
• A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization

  Yu Kawamata; Takuya Hashimoto; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2016, Peer-reviewed

  
• Synthesis of N-Boc-Propargylic and Allylic Amines by Reaction of Organomagnesium Reagents with N-Boc-Aminals and Their Oxidation to N-Boc-Ketimines

  Taichi Kano; Ryohei Kobayashi; Keiji Maruoka

  ORGANIC LETTERS, Jan. 2016, Peer-reviewed

  
• Efficient photolytic C-H bond functionalization of alkylbenzene with hypervalent iodine(III) reagent

  Ryu Sakamoto; Tsubasa Inada; Sermadurai Selvakumar; Shin A. Moteki; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• Efficient generation of perfluoroalkyl radicals from sodium perfluoroalkanesulfinates and a hypervalent iodine(III) reagent: mild, metal-free synthesis of perfluoroalkylated organic molecules

  Ryu Sakamoto; Hirotaka Kashiwagi; Sermadurai Selvakumar; Shin A. Moteki; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, Peer-reviewed

  
• Design of bifunctional quaternary phosphonium salt catalysts for CO2 fixation reaction with epoxides under mild conditions

  Shiyao Liu; Naoki Suematsu; Keiji Maruoka; Seiji Shirakawa

  GREEN CHEMISTRY, 2016, Peer-reviewed

  
• Effect of aging at room temperature on hydrogen embrittlement behavior of Ni-Ti superelastic alloy immersed in acidic fluoride solution

  Ogawa Toshio; Oda Tetsuro; Maruoka Kuniaki; Sakai Jun'ichi

  INTERNATIONAL JOURNAL OF MECHANICAL AND MATERIALS ENGINEERING, Dec. 2015, Peer-reviewed

  
• Boronic Acid-Catalyzed, Highly Enantioselective Aza-Michael Additions of Hydroxamic Acid to Quinone Imine Ketals

  Takuya Hashimoto; Alberto Osuna Galvez; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2015, Peer-reviewed

  
• Tetraalkylammonium Salts as Hydrogen-Bonding Catalysts

  Seiji Shirakawa; Shiyao Liu; Shiho Kaneko; Yusuke Kumatabara; Airi Fukuda; Yumi Omagari; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Dec. 2015, Peer-reviewed

  
• Positive Effect of Water in Asymmetric Direct Aldol Reactions with Primary Amine Organocatalyst: Experimental and Computational Studies

  Shin A. Moteki; Hiroki Maruyama; Keiji Nakayama; Hai-Bei Li; Galina Petrova; Satoshi Maeda; Keiji Morokuma; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Oct. 2015, Peer-reviewed

  
• Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions (vol 115, pg 5366, 2015)

  Takuya Hashimoto; Keiji Maruoka

  CHEMICAL REVIEWS, Sep. 2015, Peer-reviewed

  
• Mechanism of Metal-Free C-H Activation of Branched Aldehydes and Acylation of Alkenes Using Hypervalent Iodine Compound: A Theoretical Study

  Julong Jiang; Romain Ramozzi; Shin Moteki; Asuka Usui; Keiji Maruoka; Keiji Morokuma

  JOURNAL OF ORGANIC CHEMISTRY, Sep. 2015, Peer-reviewed

  
• Versatile In Situ Generated N-Boc-Imines: Application to Phase-Transfer-Catalyzed Asymmetric Mannich-Type Reactions

  Taichi Kano; Ryohei Kobayashi; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2015, Peer-reviewed

  
• Regio- and Stereoselective Conjugate Addition of Aldehydes to beta-Tosyl Enones under the Catalysis of a Binaphthyl-Modified Chiral Amine

  Taichi Kano; Hisashi Sugimoto; Hiroki Maruyama; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2015, Peer-reviewed

  
• Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

  Takuya Hashimoto; Keiji Maruoka

  CHEMICAL REVIEWS, Jun. 2015, Peer-reviewed

  
• Catalytic Asymmetric Diels-Alder Reaction of Quinone Imine Ketals: A Site-Divergent Approach

  Takuya Hashimoto; Hiroki Nakatsu; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Apr. 2015, Peer-reviewed

  
• Phase-Transfer-Catalyzed Asymmetric SNAr Reaction of alpha-Amino Acid Derivatives with Arene Chromium Complexes

  Seiji Shirakawa; Kenichiro Yamamoto; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jan. 2015, Peer-reviewed

  
• Regioselectivity switch in chiral amine-catalysed asymmetric addition of aldehydes to reactive enals

  Taichi Kano; Hiroki Maruyama; Ryu Sakamoto; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• Phase-transfer-catalyzed asymmetric desymmetrizations of cyclopentanones

  Seiji Shirakawa; Takashi Tokuda; S. B. Jennifer Kan; Keiji Maruoka

  ORGANIC CHEMISTRY FRONTIERS, 2015, Peer-reviewed

  
• Bronsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines

  Taichi Kano; Yusuke Aota; Daisuke Asakawa; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• Metal-Free C-H Bond Activation of Branched Aldehydes with a Hypervalent Iodine(III) Catalyst under Visible-Light Photolysis: Successful Trapping with Electron-Deficient Olefins

  Shin A. Moteki; Asuka Usui; Sermadurai Selvakumar; Tiexin Zhang; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Oct. 2014, Peer-reviewed

  
• Effect of Bronsted acid co-catalyst in asymmetric conjugate addition of 3-aryloxindoles to maleimide under base-free phase-transfer conditions

  Seiji Shirakawa; Hiroki Makino; Tomofumi Yoshidome; Keiji Maruoka

  TETRAHEDRON, Oct. 2014, Peer-reviewed

  
• A Practical Approach for the Oxidation of Unactivated C-sp3-H Bonds with o-Nitro(diacetoxyiodo)benzene as an Efficient Hypervalent Iodine(III)-Based Oxidizing Agent

  Shin A. Moteki; Sermadurai Selvakumar; Tiexin Zhang; Asuka Usui; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Sep. 2014, Peer-reviewed

  
• An organic thiyl radical catalyst for enantioselective cyclization

  Takuya Hashimoto; Yu Kawamata; Keiji Maruoka

  NATURE CHEMISTRY, Aug. 2014, Peer-reviewed

  
• Design and synthesis of a biphenyl-based chiral amino sulfonamide with high catalytic performance in Mannich reactions

  Taichi Kano; Hiroki Maruyama; Koichiro Akiyama; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2014, Peer-reviewed

  
• Asymmetric phase-transfer reactions under base-free neutral conditions

  Seiji Shirakawa; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2014, Peer-reviewed

  
• A Base-Free Neutral Phase-Transfer Reaction System

  Seiji Shirakawa; Lijia Wang; Rongjun He; Satoru Arimitsu; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Jun. 2014, Peer-reviewed

  
• Catalytic Asymmetric Synthesis of 3,3 '-Diaryloxindoles as Triarylmethanes with a Chiral All-Carbon Quaternary Center: Phase-Transfer-Catalyzed SNAr Reaction

  Seiji Shirakawa; Kenta Koga; Takashi Tokuda; Kenichiro Yamamoto; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jun. 2014, Peer-reviewed

  
• Synthesis of 3-Mono-Substituted Binaphthyl-Based Secondary Amine Catalysts via Monobromination of an Axially Chiral Dicarboxylic Acid Derivative

  Taichi Kano; Momotaro Takeda; Ryu Sakamoto; Keiji Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, May 2014, Peer-reviewed

  
• Asymmetric Phase-Transfer Catalysis with Homo- and Heterochiral Quaternary Ammonium Salts: A Theoretical Study

  Galina P. Petrova; Hai-Bei Li; Keiji Maruoka; Keiji Morokuma

  JOURNAL OF PHYSICAL CHEMISTRY B, May 2014, Peer-reviewed

  
• Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions

  Fei Deng; Shin A. Moteki; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Apr. 2014, Peer-reviewed

  
• Phase- Transfer- Catalyzed Asymmetric a- Arylation of a- Amino Acid Derivatives

  Seiji Shirakawa; Kenichiro Yamamoto; Takashi Tokuda; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Apr. 2014, Peer-reviewed

  
• Practical Approach for Asymmetric Hydroxyamination of Aldehydes with in Situ Generated Nitrosocarbonyl Compounds: Application to One-Pot Synthesis of Chiral Allylamines

  Taichi Kano; Fumitaka Shirozu; Keiji Maruoka

  ORGANIC LETTERS, Mar. 2014, Peer-reviewed

  
• Amine-Catalyzed Asymmetric Cross-Aldol Reactions Using Heterofunctionalized Acetaldehydes as Nucleophiles

  Taichi Kano; Ryu Sakamoto; Keiji Maruoka

  ORGANIC LETTERS, Feb. 2014, Peer-reviewed

  
• Chiral Bronsted acid-catalyzed enantioselective addition of indoles to ketimines

  Taichi Kano; Ryosuke Takechi; Ryohei Kobayashi; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, Feb. 2014, Peer-reviewed

  
• Efficient asymmetric synthesis of spiro-2(3H)-furanones via phase-transfer-catalyzed alkynylation

  Xiangfei Wu; Seiji Shirakawa; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, Peer-reviewed

  
• Catalytic enantioselective intramolecular cyclization of N-aryl diazoamides using a titanium-BINOLate complex

  Takuya Hashimoto; Kumiko Yamamoto; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Remote chirality control based on the organocatalytic asymmetric Mannich reaction of alpha-thio acetaldehydes

  Taichi Kano; Ryu Sakamoto; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Kinetic Resolution of Axially Chiral 2-Amino-1,1 '-Biaryls by Phase-Transfer-Catalyzed N-Allylation

  Seiji Shirakawa; Xiangfei Wu; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Dec. 2013, Peer-reviewed

  
• Metal-Free Enantioselective Hydroxyamination of Aldehydes with Nitrosocarbonyl Compounds Catalyzed by an Axially Chiral Amine

  Taichi Kano; Fumitaka Shirozu; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2013, Peer-reviewed

  
• Phase-Transfer-Catalyzed Asymmetric Synthesis of Axially Chiral Anilides

  Kun Liu; Xiangfei Wu; S. B. Jennifer Kan; Seiji Shirakawa; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Dec. 2013, Peer-reviewed

  
• In situ assembled boronate ester assisted chiral carboxylic acid catalyzed asymmetric trans-aziridinations

  Takuya Hashimoto; Alberto Osuna Gálvez; Keiji Maruoka

  Journal of the American Chemical Society, 27 Nov. 2013, Peer-reviewed

  
• Chiral Organotin Hydride Catalyzed Enantioselective Radical Cyclization of Aldehydes

  Seiji Shirakawa; Asuka Usui; S. B. Jennifer Kan; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Nov. 2013, Peer-reviewed

  
• Development of Synthetic Transformations by Control of Acid-Catalyzed Reactions of Diazocarbonyl Compounds

  Takuya Hashimoto; Keiji Maruoka

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Nov. 2013, Peer-reviewed

  
• Axially Chiral Dicarboxylic Acid Catalyzed Activation of Quinone Imine Ketals: Enantioselective Arylation of Enecarbamates

  Takuya Hashimoto; Hiroki Nakatsu; Yuka Takiguchi; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2013, Peer-reviewed

  
• Organocatalytic Asymmetric Synthesis of Propargylamines with Two Adjacent Stereocenters: Mannich-Type Reactions of In Situ Generated C-Alkynyl Imines with beta-Keto Esters

  Taichi Kano; Taiga Yurino; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Oct. 2013, Peer-reviewed

  
• Site-Selective Oxidation of Unactivated C-sp3-H Bonds with Hypervalent Iodine(III) Reagents

  Shin A. Moteki; Asuka Usui; Tiexin Zhang; Cesar R. Solorio Alvarado; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Aug. 2013, Peer-reviewed

  
• Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kappa B Activation

  Masaaki Ozawa; Masaki Morita; Go Hirai; Satoru Tamura; Masao Kawai; Ayako Tsuchiya; Kana Oonuma; Keiji Maruoka; Mikiko Sodeoka

  ACS MEDICINAL CHEMISTRY LETTERS, Aug. 2013, Peer-reviewed

  
• Catalytic Asymmetric Three-Component 1,3-Dipolar Cycloaddition of Aldehydes, Hydrazides, and Alkynes

  Takuya Hashimoto; Yuka Takiguchi; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2013, Peer-reviewed

  
• Design of Chiral Bifunctional Quaternary Phosphonium Bromide Catalysts Possessing an Amide Moiety

  Seiji Shirakawa; Takashi Tokuda; Atsuyuki Kasai; Keiji Maruoka

  ORGANIC LETTERS, Jul. 2013, Peer-reviewed

  
• Production at the Curie Level of No-Carrier-Added 6-F-18-Fluoro-L-Dopa

  Lionel C. Libert; Xavier Franci; Alain R. Plenevaux; Takashi Ooi; Keiji Maruoka; Andre J. Luxen; Christian F. Lemaire

  JOURNAL OF NUCLEAR MEDICINE, Jul. 2013, Peer-reviewed

  
• Development of Axially Chiral Dicarboxylic Acid Catalyzed Asymmetric Transformations

  Takuya Hashimoto; Keiji Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, May 2013, Peer-reviewed

  
• Construction of a Chiral Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 2-Arylcyclohexanones under Phase-Transfer Conditions

  Taichi Kano; Yumi Hayashi; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2013, Peer-reviewed

  
• Recent developments in asymmetric phase-transfer reactions

  Seiji Shirakawa; Keiji Maruoka

  Angewandte Chemie - International Edition, 15 Apr. 2013, Peer-reviewed

  
• Efficient approach for the design of effective chiral quaternary phosphonium salts in asymmetric conjugate additions

  Seiji Shirakawa; Atsuyuki Kasai; Takashi Tokuda; Keiji Maruoka

  Chemical Science, 02 Apr. 2013, Peer-reviewed

  
• Phase-transfer-catalyzed asymmetric conjugate cyanation of alkylidenemalonates with KCN in the presence of a Brønsted acid additive

  Yan Liu; Seiji Shirakawa; Keiji Maruoka

  Organic Letters, 15 Mar. 2013, Peer-reviewed

  
• Phase-transfer-catalysed asymmetric synthesis of tetrasubstituted allenes

  Takuya Hashimoto; Kazuki Sakata; Fumiko Tamakuni; Mark J. Dutton; Keiji Maruoka

  NATURE CHEMISTRY, Mar. 2013, Peer-reviewed

  
• Phase-transfer-catalysed asymmetric synthesis of tetrasubstituted allenes

  Takuya Hashimoto; Kazuki Sakata; Fumiko Tamakuni; Mark J. Dutton; Keiji Maruoka

  NATURE CHEMISTRY, Mar. 2013, Peer-reviewed

  
• Reactions Triggered by Lewis Acidic Organoaluminum Species

  Yuki Naganawa; Keiji Maruoka

  MODERN ORGANOALUMINUM REAGENTS: PREPARATION, STRUCTURE, REACTIVITY AND USE, 2013, Peer-reviewed

  
• Enantioselective alkylation of 2-[(4-Chlorobenzyliden)amino]propanoic acid tert-butyl ester: Synthesis of (R)-2-amino-2-methyl-3-phenylpropanoic acid tert-butyl ester

  Seiji Shirakawa; Kenichiro Yamamoto; Kun Liu; Keiji Maruoka

  Organic Syntheses, 2013, Peer-reviewed

  
• Enantioselective alkylation of N-(Diphenylmethylene)glycinate tert-butyl ester: Synthesis of (R)-2-(Benzhydrylidenamino)-3-phenylpropanoic acid tert-butyl ester

  Seiji Shirakawa; Kenichiro Yamamoto; Kun Liu; Keiji Maruoka

  Organic Syntheses, 2013, Peer-reviewed

  
• Unusual anti-selective asymmetric conjugate addition of aldehydes to nitroalkenes catalyzed by a biphenyl-based chiral secondary amine

  Taichi Kano; Hisashi Sugimoto; Osamu Tokuda; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• Acid-Catalyzed In Situ Generation of Less Accessible or Unprecedented N-Boc Imines from N-Boc Aminals

  Taichi Kano; Taiga Yurino; Daisuke Asakawa; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed

  
• Reactions triggered by lewis acidic organoaluminum species

  Yuki Naganawa; Keiji Maruoka

  Topics in Organometallic Chemistry, 2013, Peer-reviewed

  
• One-pot cross double-Mannich reaction of acetaldehyde catalyzed by a binaphthyl-based amino sulfonamide

  Taichi Kano; Ryu Sakamoto; Yukako Yamaguchi; Ken-ichi Itoh; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

  Taichi Kano; Takeshi Kumano; Ryu Sakamoto; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, Peer-reviewed

  
• Unique properties of chiral biaryl-based secondary amine catalysts for asymmetric enamine catalysis

  Taichi Kano; Keiji Maruoka

  CHEMICAL SCIENCE, 2013, Peer-reviewed

  
• Catalytic Asymmetric Synthesis of 3-Substituted Proline Derivatives by Using Phase-Transfer-Catalyzed Conjugate Addition

  Yan Liu; Asuka Usui; Seiji Shirakawa; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Oct. 2012, Peer-reviewed

  
• In Situ Preparation of Chiral Bifunctional Catalysts and Their Application to Asymmetric Michael Addition Reactions

  Shin A. Moteki; Peter Gakio Kirira; Satoru Arimitsu; Keiji Maruoka

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Sep. 2012, Peer-reviewed

  
• Organic Chemistry: Another Ace in the Pack

  Sung Ho Kang; Keiji Maruoka; Deqing Zhang; Richard Threlfall

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Sep. 2012, Peer-reviewed

  
• Axially chiral dicarboxylic acid catalyzed asymmetric semipinacol rearrangement of cyclic beta-hydroxy-alpha-diazo esters

  Takuya Hashimoto; Shingo Isobe; Cedric K. A. Callens; Keiji Maruoka

  TETRAHEDRON, Sep. 2012, Peer-reviewed

  
• Powerful Amino Diol Catalyst for Effecting the Direct Asymmetric Conjugate Addition of Aldehydes to Acrylates

  Taichi Kano; Fumitaka Shirozu; Matsujiro Akakura; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2012, Peer-reviewed

  
• Asymmetric Phase-Transfer Catalysis

  Seiji Shirakawa; Shin A. Moteki; Keiji Maruoka

  Modern Tools for the Synthesis of Complex Bioactive Molecules, 30 Aug. 2012, Peer-reviewed

  
• The Proline-Catalyzed Mannich Reaction and the Advent of Enamine Catalysis

  Benjamin List; Sai-Hu Liao; Seiji Shirakawa; Keiji Maruoka; Liu-Zhu Gong; Wen-Jing Xiao

  Organic Chemistry - Breakthroughs and Perspectives, 23 Aug. 2012, Peer-reviewed

  
• New Neutral Reaction System with Crown Ether-KCl Complexes in Aqueous Solution

  Seiji Shirakawa; Lijia Wang; Atsuyuki Kasai; Keiji Maruoka

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2012, Peer-reviewed

  
• Kinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type Transformations

  Masaki Morita; Go Hirai; Megumi Ohkubo; Hiroyuki Koshino; Daisuke Hashizume; Keiji Maruoka; Mikiko Sodeoka

  ORGANIC LETTERS, Jul. 2012, Peer-reviewed

  
• Efficient Asymmetric Synthesis of a Bicyclic Amino Acid as a Core Structure of Telaprevir

  Seiji Shirakawa; Yan Liu; Asuka Usui; Keiji Maruoka

  CHEMCATCHEM, Jul. 2012, Peer-reviewed

  
• New chiral phase-transfer catalysts possessing a 6,6 '-bridged ring on the biphenyl unit: application to the synthesis of alpha,alpha-dialkyl-alpha-amino acids

  Yasushi Kubota; Seiji Shirakawa; Tsutomu Inoue; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2012, Peer-reviewed

  
• Stereocontrolled Synthesis of Vicinal Diamines by Organocatalytic Asymmetric Mannich Reaction of N-Protected Aminoacetaldehydes: Formal Synthesis of (-)-Agelastatin A

  Taichi Kano; Ryu Sakamoto; Matsujiro Akakura; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2012, Peer-reviewed

  
• Catalytic Asymmetric Synthesis of Axially Chiral o-lodoanilides by Phase-Transfer Catalyzed Alkylations

  Seiji Shirakawa; Kun Liu; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2012, Peer-reviewed

  
• Organocatalysis: a web collection

  Keiji Maruoka; Benjamin List; Hisashi Yamamoto; Liu-Zhu Gong

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

  
• The direct catalytic asymmetric aldol reaction of alpha-substituted nitroacetates with aqueous formaldehyde under base-free neutral phase-transfer conditions

  Seiji Shirakawa; Kensuke Ota; Shogo J. Terao; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

  
• Molecular recognition of ketomalonates by asymmetric aldol reaction of aldehydes with secondary-amine organocatalysts

  Taichi Kano; Sunhwa Song; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

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• Highly Diastereo- and Enantioselective Mannich Reactions of Synthetically Flexible Ketimines with Secondary Amine Organocatalysts

  Taichi Kano; Sunhwa Song; Yasushi Kubota; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• An Achiral-Acid-Induced Switch in the Enantioselectivity of a Chiral cis-Diamine-Based Organocatalyst for Asymmetric Aldol and Mannich Reactions

  Shin A. Moteki; Jianwei Han; Satoru Arimitsu; Matsujiro Akakura; Keiji Nakayama; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• A Catalytic Asymmetric Ugi-type Reaction With Acyclic Azomethine Imines

  Takuya Hashimoto; Hidenori Kimura; Yu Kawamata; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Designer chiral phase-transfer catalysts for green sustainable chemistry

  Keiji Maruoka

  PURE AND APPLIED CHEMISTRY, 2012, Peer-reviewed

  
• Efficient Organocatalytic Cross-Aldol Reaction between Aliphatic Aldehydes through Their Functional Differentiation

  Taichi Kano; Hisashi Sugimoto; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2011, Peer-reviewed

  
• Phase-Transfer-Catalyzed Asymmetric Synthesis of 1,1-Disubstituted Tetrahydroisoquinolines

  Seiji Shirakawa; Kun Liu; Hironobu Ito; Thanh Nguyen Le; Keiji Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Oct. 2011, Peer-reviewed

  
• Catalytic Asymmetric Synthesis of Isoxazoline-N-oxides through Conjugate Addition-Cyclization under Phase-Transfer Conditions

  Taichi Kano; Akihiro Yamamoto; Sunhwa Song; Keiji Maruoka

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Oct. 2011, Peer-reviewed

  
• Phase-transfer-catalyzed Asymmetric Alkylation with Epoxy Triflates as Alkylating Agents: Highly Stereoselective Synthesis of gamma,delta-Epoxy-alpha-amino Acids

  Satont Arimitsu; Daisuke Kato; Keiji Maruoka

  CHEMISTRY LETTERS, Oct. 2011, Peer-reviewed

  
• Generation and exploitation of acyclic azomethine imines in chiral Bronsted acid catalysis

  Takuya Hashimoto; Hidenori Kimura; Yu Kawamata; Keiji Maruoka

  NATURE CHEMISTRY, Aug. 2011, Peer-reviewed

  
• Award Address (Arthur C. Cope Scholar Awards (CSS) sponsored by The Arthur C. Cope Fund). Design of high-performance bifunctional organocatalysts for practical asymmetric synthesis

  Keiji Maruoka

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• Synthetic Application and Structural Elucidation of Axially Chiral Dicarboxylic Acid: Asymmetric Mannich-type Reaction with Diazoacetate, (Diazomethyl)phosphonate, and (Diazomethyl)sulfone

  Takuya Hashimoto; Hidenori Kimura; Hiroki Nakatsu; Keiji Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, Aug. 2011, Peer-reviewed

  
• Generation and exploitation of acyclic azomethine imines in chiral Bronsted acid catalysis

  Takuya Hashimoto; Hidenori Kimura; Yu Kawamata; Keiji Maruoka

  NATURE CHEMISTRY, Aug. 2011, Peer-reviewed

  
• Modular Synthesis of Axially Chiral 3,3 '-Disilyl Dicarboxylic Acids by Silalactones

  Takuya Hashimoto; Toshiki Takagaki; Hidenori Kimura; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Aug. 2011, Peer-reviewed

  
• Desymmetrizing Asymmetric Ring Expansion of Cyclohexanones with alpha-Diazoacetates Catalyzed by Chiral Aluminum Lewis Acid

  Takuya Hashimoto; Yuki Naganawa; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2011, Peer-reviewed

  
• Chiral Bronsted Acid-Catalyzed Asymmetric Trisubstituted Aziridine Synthesis Using alpha-Diazoacyl Oxazolidinones

  Takuya Hashimoto; Hiroki Nakatsu; Kumiko Yamamoto; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2011, Peer-reviewed

  
• Development of a Practical Synthetic Method for N-tert-Butoxycarbonyl alpha-Ketimino Esters

  Takuya Hashimoto; Kumiko Yamamoto; Keiji Maruoka

  CHEMISTRY LETTERS, Mar. 2011, Peer-reviewed

  
• Asymmetric Trisubstituted Aziridination of Aldimines and Ketimines using N-alpha-Diazoacyl Camphorsultams

  Takuya Hashimoto; Hiroki Nakatsu; Kumiko Yamamoto; Shogo Watanabe; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Feb. 2011, Peer-reviewed

  
• Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by Cu-I/Chiral Bronsted Acid Co-Catalyst

  Takuya Hashimoto; Masato Omote; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-beta-carbolines by phase-transfer catalyzed alkylations

  Seiji Shirakawa; Kun Liu; Hironobu Ito; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed

  
• The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst

  Taichi Kano; Fumitaka Shirozu; Koichi Tatsumi; Yasushi Kubota; Keiji Maruoka

  CHEMICAL SCIENCE, 2011, Peer-reviewed

  
• syn-Selective asymmetric cross-aldol reactions between aldehydes and glyoxylic acid derivatives catalyzed by an axially chiral amino sulfonamide

  Taichi Kano; Akira Noishiki; Ryu Sakamoto; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed

  
• Diastereo- and enantioselective conjugate addition of alpha-substituted nitroacetates to maleimides under base-free neutral phase-transfer conditions

  Seiji Shirakawa; Shogo J. Terao; Rongjun He; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed

  
• Asymmetric Neutral Amination of Nitroolefins Catalyzed by Chiral Bifunctional Ammonium Salts in Water-Rich Biphasic Solvent

  Lijia Wang; Seiji Shirakawa; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines: An Umpolung Strategy

  Takuya Hashimoto; Masato Omote; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions

  Taichi Kano; Akihiro Yamamoto; Sunhwa Song; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed

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• Design of Structurally Rigid trans-Diamine-Based Tf-Amide Organocatalysts with a Dihydroanthracene Framework for Asymmetric Conjugate Additions of Heterosubstituted Aldehydes to Vinyl Sulfones

  Shin A. Moteki; Senmiao Xu; Satoru Arimitsu; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2010, Peer-reviewed

  
• Development of Highly Selective Organic Reactions Catalyzed by Designed Amine Organocatalysts

  Taichi Kano; Keiji Maruoka

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Dec. 2010, Peer-reviewed

  
• Catalytic asymmetric synthesis of cyclic amino acids and alkaloid derivatives: application to (+)-dihydropinidine and Selfotel synthesis

  Taichi Kano; Takeshi Kumano; Ryu Sakamoto; Keiji Maruoka

  CHEMICAL SCIENCE, Oct. 2010, Peer-reviewed

  
• Highly Practical Amino Acid and Alkaloid Synthesis Using Designer Chiral Phase Transfer Catalysts as High-Performance Organocatalysts

  Keiji Maruoka

  CHEMICAL RECORD, Oct. 2010, Peer-reviewed

  
• Erratum: Catalytic enantioselective 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with α,β-unsaturated aldehydes (Journal of the American Chemical Society (2010) 132 (40764077))

  T. Hashimoto; Y. Maeda; M. Omote; H. Nakatsu; K. Maruoka

  Journal of the American Chemical Society, 25 Aug. 2010, Peer-reviewed

  
• Phase-Transfer-Catalyzed Olefin Isomerization/alpha-Alkylation of alpha-Alkynylcrotonates as a Route for 1,4-Enynes

  Takuya Hashimoto; Kazuki Sakata; Keiji Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Jul. 2010, Peer-reviewed

  
• Asymmetric Phase-Transfer Catalysis for the Production of Non-Proteinogenic α-Amino Acids

  Masaya Ikunaka; Keiji Maruoka

  Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions: Second Edition, 08 Jun. 2010, Peer-reviewed

  
• Catalytic asymmetric synthesis of cyclic alpha-alkyl-amino acid derivatives by C,N-double alkylation

  Taichi Kano; Ryu Sakamoto; Haruka Mii; Yong-Gang Wang; Keiji Maruoka

  TETRAHEDRON, Jun. 2010, Peer-reviewed

  
• Axially chiral dicarboxylic acid-catalyzed asymmetric imino aza-enamine reaction/oxidation as a Strecker reaction surrogate

  Takuya Hashimoto; Hidenori Kimura; Keiji Maruoka

  TETRAHEDRON-ASYMMETRY, May 2010, Peer-reviewed

  
• Phase-Transfer Catalyzed Asymmetric Conjugate Additions of beta-Ketoesters to Acetylenic Ketones

  Quan Lan; Xisheng Wang; Seiji Shirakawa; Keiji Maruoka

  ORGANIC PROCESS RESEARCH & DEVELOPMENT, May 2010, Peer-reviewed

  
• Stereoselective Synthesis of Trisubstituted Aziridines with N-alpha-Diazoacyl Camphorsultam

  Takuya Hashimoto; Hiroki Nakatsu; Shogo Watanabe; Keiji Maruoka

  ORGANIC LETTERS, Apr. 2010, Peer-reviewed

  
• Asymmetric Organocatalysis

  Allan J.B. Watson; David W.C. MacMillan; Yi Wang; Li Deng; Seiji Shirakawa; Keiji Maruoka

  Catalytic Asymmetric Synthesis: Third Edition, 26 Mar. 2010, Peer-reviewed

  
• Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with alpha,beta-Unsaturated Aldehydes

  Takuya Hashimoto; Yuko Maeda; Masato Omote; Hiroki Nakatsu; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2010, Peer-reviewed

  
• Enantioselective Formal Alkenylations of Imines Catalyzed by Axially Chiral Dicarboxylic Acid Using Vinylogous Aza-Enamines

  Takuya Hashimoto; Hidenori Kimura; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, Peer-reviewed

  
• Direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine: highly enantio- and diastereoselective one-pot synthesis of bromohydrins

  Taichi Kano; Fumitaka Shirozu; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2010, Peer-reviewed

  
• Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis

  Takuya Hashimoto; Kazuhiro Fukumoto; Naoyuki Abe; Kazuki Sakata; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2010, Peer-reviewed

  
• Metal-Free Direct Asymmetric Aminoxylation of Aldehydes Catalyzed by a Binaphthyl-Based Chiral Amine

  Taichi Kano; Haruka Mii; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, Peer-reviewed

  
• Desymmetrizing asymmetric ring expansion: stereoselective synthesis of 7-membered cyclic beta-keto carbonyl compounds with an alpha-hydrogen

  Takuya Hashimoto; Yuki Naganawa; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2010, Peer-reviewed

  
• Phase-Transfer-Catalyzed Asymmetric Alkylation of alpha-Benzoyloxy-beta-keto Esters: Stereoselective Construction of Congested 2,3-Dihydroxycarboxylic Acid Esters

  Takuya Hashimoto; Keigo Sasaki; Kazuhiro Fukumoto; Yuichi Murase; Naoyuki Abe; Takashi Ooi; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, 2010, Peer-reviewed

  
• Chiral bifunctional phase transfer catalysts for asymmetric fluorination of beta-keto esters

  Xisheng Wang; Quan Lan; Seiji Shirakawa; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2010, Peer-reviewed

  
• Enantioselective Base-Free Phase-Transfer Reaction in Water-Rich Solvent

  Rongjun He; Seiji Shirakawa; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2009, Peer-reviewed

  
• Al Lewis acid-catalyzed regiodivergent 1,2-rearrangement of alpha-siloxy aldehydes: scope and mechanism

  Kohsuke Ohmatsu; Takayuki Tanaka; Takashi Ooi; Keiji Maruoka

  TETRAHEDRON, Sep. 2009, Peer-reviewed

  
• Design of Sophisticated Bidentate Lewis Acids and Organocatalysts for Fine Organic Synthesis

  Keiji Maruoka

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Aug. 2009, Peer-reviewed

  
• Stereoselective Synthesis of alpha-Alkyl-beta-keto Imides via Asymmetric Redox C-C Bond Formation between alpha-Alkyl-alpha-diazocarbonyl Compounds and Aldehydes

  Takuya Hashimoto; Hisashi Miyamoto; Yuki Naganawa; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2009, Peer-reviewed

  
• Binaphthyl-Modified Quaternary Phosphonium Salts as Chiral Phase Transfer Catalysts: Application to Asymmetric Amination of beta-Keto Esters

  Rongjun He; Keiji Maruoka

  SYNTHESIS-STUTTGART, Jul. 2009, Peer-reviewed

  
• Highly efficient asymmetric amination of beta-keto esters catalyzed by chiral quaternary ammonium bromides

  Quan Lan; Xisheng Wang; Rongjun He; Changhua Ding; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2009, Peer-reviewed

  
• Catalytic asymmetric synthesis of cyclic alpha-alkyl-amino acid derivatives having a tetrasubstituted alpha-carbon

  Yong-Gang Wang; Haruka Mii; Taichi Kano; Keiji Maruoka

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2009, Peer-reviewed

  
• Stereoselective Construction of Seven-Membered Rings with an All-Carbon Quaternary Center by Direct Tiffeneau-Demjanov-type Ring Expansion

  Takuya Hashimoto; Yuki Naganawa; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2009, Peer-reviewed

  
• Organocatalytic Approach to Enantioselective One-Pot Synthesis of Pyrrolidine, Hexahydropyrrolizine, and Octahydroindolizine Core Structures

  Yong-Gang Wang; Takeshi Kumano; Taichi Kano; Keiji Maruoka

  ORGANIC LETTERS, May 2009, Peer-reviewed

  
• Rate Enhancement of Phase Transfer Catalyzed Conjugate Additions by CsCl

  Taichi Kano; Takeshi Kumano; Keiji Maruoka

  ORGANIC LETTERS, May 2009, Peer-reviewed

  
• Enantioselectivity Switch in Direct Asymmetric Aminoxylation Catalyzed by Binaphthyl-Based Chiral Secondary Amines

  Taichi Kano; Akihiro Yamamoto; Fumitaka Shirozu; Keiji Maruoka

  SYNTHESIS-STUTTGART, May 2009, Peer-reviewed

  
• Asymmetric Phase-Transfer Catalysis as a Practical Organocatalytic Method

  Keiji Maruoka

  SYNLETT, Mar. 2009, Peer-reviewed

  
• Direct Asymmetric Benzoyloxylation of Aldehydes Catalyzed by 2-Tritylpyrrolidine

  Taichi Kano; Haruka Mii; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009, Peer-reviewed

  
• Phase-Transfer-Catalyzed Enantioselective Alkylation of alpha-Benzoyloxy-beta-Keto Ester

  Takuya Hashimoto; Keigo Sasaki; Kazuhiro Fukumoto; Yuichi Murase; Takashi Ooi; Keiji Maruoka

  SYNLETT, Mar. 2009, Peer-reviewed

  
• Enantioselective Alkylation of alpha-Fluoro-beta-Keto Esters by Asymmetric Phase-Transfer Catalysis

  Changhua Ding; Keiji Maruoka

  SYNLETT, Mar. 2009, Peer-reviewed

  
• alpha-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective alpha Alkylation of alpha-Alkyl-alpha-alkynyl Esters

  Takuya Hashimoto; Kazuki Sakata; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed

  
• Catalytic enantioselective construction of all-carbon quaternary stereocenters by an organocatalytic Diels-Alder reaction of alpha-substituted alpha, beta-unsaturated aldehydes

  Taichi Kano; Youhei Tanaka; Kenta Osawa; Taiga Yurino; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed

  
• A Designer Axially Chiral Amino Sulfonamide as an Efficient Organocatalyst for Direct Asymmetric anti-Selective Mannich Reactions and syn-Selective Cross-Aldol Reactions

  Taichi Kano; Yukako Yamaguchi; Keiji Maruoka

  CHEMISTRY-A EUROPEAN JOURNAL, 2009, Peer-reviewed

  
• Phosphonium Salts as Chiral Phase-Transfer Catalysts: Asymmetric Michael and Mannich Reactions of 3-Aryloxindoles

  Rongjun He; Changhua Ding; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed

  
• Organocatalyzed direct asymmetric alpha-halogenation of carbonyl compounds

  Mitsuhiro Ueda; Taichi Kano; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, Peer-reviewed

  
• A Designer Axially Chiral Amino Sulfonamide as an Efficient Organocatalyst for Direct Asymmetric Mannich Reactions of N-Boc-Protected Imines

  Taichi Kano; Yukako Yamaguchi; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed

  
• Complete Switch of Product Selectivity in Asymmetric Direct Aldol Reaction with Two Different Chiral Organocatalysts from a Common Chiral Source

  Keiji Nakayama; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2008, Peer-reviewed

  
• Design of an Axially Chiral Dicarboxylic Acid and Its Application in Syntheses of Optically Active beta-Amino Acids and beta-Amino Phosphonic Acid Derivatives

  Takuya Hashimoto; Keiji Maruoka

  SYNTHESIS-STUTTGART, Nov. 2008, Peer-reviewed

  
• Trans-Selective Asymmetric Aziridination of Diazoacetamides and N-Boc Imines Catalyzed by Axially Chiral Dicarboxylic Acid

  Takuya Hashimoto; Nanase Uchiyama; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2008, Peer-reviewed

  
• Asymmetric Phase-Transfer Catalysis

  Xisheng Wang; Quan Lan; Keiji Maruoka

  Handbook of Asymmetric Heterogeneous Catalysis, 12 Sep. 2008, Peer-reviewed

  
• A tribute to Professor Ryoji Noyori on the occasion of his 70(th) birthday

  Joe P. Richmond; Martin Banwell; Daniel Bellus; Kilian Muniz; Koichi Narasaka; Yoshio Okamoto; Jun Okuda; Manfred Schlosser; Ichiro Shinkai; Kuniaki Tatsuta; Gerard van Koten; Xiao-Zeng You; Varinder K. Aggarwal; Takuzo Aida; Howard Alper; Chunli Bai; Kankan Bhattacharyya; Hans-Ulrich Blaser; Benoit Pugin; Felix Spindler; John M. Brown; Stephen L. Buchwald; Albert S. C. Chan; Naoto Chatani; Scott E. Denmark; Francois Diederich; Michael P. Doyle; Greg Fu; Akira Fujishima; Stephen Hanessian; Shunichi Hashimoto; Masahiko Hayashi; Tamejiro Hiyama; Peter Hofmann; Zhaomin Hou; Tsuneo Imamoto; Kunisuke Izawa; Eric Jacobsen; Tsutomu Katsuki; Sunggak Kim; Shu Kobayashi; Koichi Komatsu; Hidenori Kumobayashi; E. Peter Kuendig; Eun Lee; Walter Leitner; Steven V. Ley; Bruce Lipshutz; Lu Yixin; Keiji Maruoka; Shun-Ichi Murahashi; Shinji Murai; K. C. Nicolaou; Hisao Nishiyama; Takeshi Ohkuma; Tetsuo Ohta; Koichiro Oshima; Junzo Otera; Andreas Pfaltz; Manfred T. Reetz; Alfredo Ricci; Mitsuo Sawamoto; Michelangelo Scalone; K. Barry Sharpless; Roger Sheldon; Victor Snieckus; Mikiko Sodeoka; Makoto Tokunaga; Kiyoshi Tomioka; Yoshio Umezawa; Yasuhiro Uozumi; Chi-Huey Wong; Henry N. C. Wong; Yoshinori Yamamoto; Daoben Zhu

  ADVANCED SYNTHESIS & CATALYSIS, Sep. 2008, Peer-reviewed

  
• Facile synthesis of structurally diverse 3,3 '-disubstituted 1,1 '-binaphthyl-2,2 '-diamines in optically pure forms

  Taichi Kano; Youhei Tanaka; Kenta Osawa; Taiga Yurino; Keiji Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, Sep. 2008, Peer-reviewed

  
• Practical asymmetric synthesis of alpha-methylserine derivatives under mild phase-transfer conditions

  Keiji Nakayama; Keiji Maruoka

  TETRAHEDRON LETTERS, Sep. 2008, Peer-reviewed

  
• Direct asymmetric aminoxylation reaction catalyzed by a binaphthyl-based chiral amino sulfonamide with high catalytic performance

  Taichi Kano; Akihiro Yamamoto; Keiji Maruoka

  TETRAHEDRON LETTERS, Sep. 2008, Peer-reviewed

  
• Practical aspects of recent asymmetric phase-transfer, catalysis

  Keiji Maruoka

  ORGANIC PROCESS RESEARCH & DEVELOPMENT, Jul. 2008, Peer-reviewed

  
• Chiral Quaternary Ammonium Fluorides for Asymmetric Synthesis

  Keiji Maruoka; Seiji Shirakawa; Takashi Ooi

  Asymmetric Phase Transfer Catalysis, 11 Jun. 2008, Peer-reviewed

  
• The Basic Principle of Phase-Transfer Catalysis and Some Mechanistic Aspects

  Takuya Hashimoto; Keiji Maruoka

  Asymmetric Phase Transfer Catalysis, 11 Jun. 2008, Peer-reviewed

  
• Binaphthyl-and Biphenyl-Modified Chiral Phase-Transfer Catalysts for Asymmetric Synthesis

  Keiji Maruoka

  Asymmetric Phase Transfer Catalysis, 11 Jun. 2008, Peer-reviewed

  
• Asymmetric Phase Transfer Catalysis

  Keiji Maruoka

  Asymmetric Phase Transfer Catalysis, 11 Jun. 2008, Peer-reviewed

  
• Asymmetric imino aza-enamine reaction catalyzed by axially chiral dicarboxylic acid: Use of arylaldehyde N,N-dialkylhydrazones as acyl anion equivalent

  Takuya Hashimoto; Maya Hirose; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2008, Peer-reviewed

  
• Direct asymmetric aminoxylation reaction catalyzed by axially chiral amino acids

  Taichi Kano; Akihiro Yamamoto; Haruka Mii; Jun Takai; Seiji Shirakawa; Keiji Maruoka

  CHEMISTRY LETTERS, Mar. 2008, Peer-reviewed

  
• Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst

  Taichi Kano; Mitsuhiro Ueda; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2008, Peer-reviewed

  
• Combinatorial approach for the design of new, simplified chiral phase-transfer catalysts with high catalytic performance for practical asymmetric synthesis of alpha-alkyl-alpha-amino acids

  Masanori Kitamura; Yuichiro Arimura; Seiji Shirakawa; Keiji Maruoka

  TETRAHEDRON LETTERS, Mar. 2008, Peer-reviewed

  
• Brønsted acid-catalyzed insertion of aryldiazoacetates to sp 2 carbon-CHO bond: Facile construction of chiral all-carbon quaternary center

  Takuya Hashimoto; Yuki Naganawa; Keiji Maruoka

  Journal of the American Chemical Society, 27 Feb. 2008, Peer-reviewed

  
• anti-Selective direct asymmetric Mannich reactions catalyzed by chiral pyrrolidine-based amino sulfonamides

  Taichi Kano; Yoshio Hato; Akihiro Yamamoto; Keiji Maruoka

  TETRAHEDRON, Feb. 2008, Peer-reviewed

  
• Preface

  K. Maruoka

  Asymmetric Phase Transfer Catalysis, 2008, Peer-reviewed

  
• Complete switch of migratory aptitude in aluminum-catalyzed 1,2-rearrangement of differently alpha,alpha-disubstituted alpha-siloxy aldehydes

  Kohsuke Ohmatsu; Takayuki Tanaka; Takashi Ooi; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, Peer-reviewed

  
• Asymmetric 1,3-dipolar cycloadditions of N-benzyl and N-diphenylmethyl nitrones and alpha,beta-unsaturated aldehydes catalyzed by bis-titanium chiral Lewis acids

  Takuya Hashimoto; Masato Omote; Yoshio Hato; Taichi Kano; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, 2008, Peer-reviewed

  
• Syntheses of manzacidins: a stage for the demonstration of synthetic methodologies

  Takuya Hashimoto; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, Peer-reviewed

  
• Combinatorial design of simplified high-performance chiral phase-transfer catalysts for practical asymmetric synthesis of alpha-alkyl- and alpha,alpha-dialkyl-alpha-amino acids

  Masanori Kitamura; Seiji Shirakawa; Yuichiro Arimura; Xisheng Wang; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, 2008, Peer-reviewed

  
• Binaphthyl-Modiried Quaternary Phosphonium Salts as Chiral Phase-Transfer Catalysts: Asymmetric Amination of beta-Keto Esters

  Rongjun He; Xisheng Wang; Takuya Hashimoto; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, Peer-reviewed

  
• Design of chiral bifunctional secondary amine catalysts for asymmetric enamine catalysis

  Taichi Kano; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2008, Peer-reviewed

  
• 6,6 '-substituent effect of BINOL in bis-titanium chiral Lewis acid catalyzed 1,3-dipolar cycloaddition of nitrones

  Takuya Hashimoto; Masato Omote; Keiji Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, Peer-reviewed

  
• Recent development and application of chiral phase-transfer catalysts

  Takuya Hashimoto; Keiji Maruoka

  CHEMICAL REVIEWS, Dec. 2007, Peer-reviewed

  
• Asymmetric 1,3-dipolar cycloadditions of nitrones and methacrolein catalyzed by chiral bis-titanium lewis acid: A dramatic effect of N-substituent on nitrone

  Takuya Hashimoto; Masato Omote; Taichi Kano; Keiji Maruoka

  ORGANIC LETTERS, Nov. 2007, Peer-reviewed

  
• Practical stereloselective synthesis of beta-branched alpha-amino acids through efficient kinetic resolution in the phase-transfer-catalyzed asymmetric alkylations

  Takashi Ooi; Daisuke Kato; Koji Inamura; Kohsuke Ohmatsu; Keiji Maruoka

  ORGANIC LETTERS, Sep. 2007, Peer-reviewed

  
• Preface

  Keiji Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Aug. 2007, Peer-reviewed

  
• Design of axially chiral dicarboxylic acid for asymmetric Mannich reaction of arylaldehyde N-Boc imines and diazo compounds

  Takuya Hashimoto; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2007, Peer-reviewed

  
• Asymmetric organocatalytic oxy-Michael addition of alcohols to alpha,beta-unsaturated aldehydes

  Taichi Kano; Youhei Tanaka; Keiji Maruoka

  TETRAHEDRON, Aug. 2007, Peer-reviewed

  
• Asymmetric conjugate additions of alpha-substituted-alpha-cyanoacetates to acetylenic ketones by chiral phase transfer catalysis

  Quan Lan; Xisheng Wang; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2007, Peer-reviewed

  
• Convenient preparation of chiral phase-transfer catalysts with conformationally fixed biphenyl core for catalytic asymmetric synthesis of alpha-alkyl- and alpha,alpha-dialkyl-alpha-amino acids: application to the short asymmetric synthesis of BIRT-377

  Yong-Gang Wang; Mitsuhiro Ueda; Xisheng Wang; Zhenfu Han; Keiji Maruoka

  TETRAHEDRON, Jun. 2007, Peer-reviewed

  
• Design of chiral phase transfer catalyst with conformationally fixed biphenyl core: Application to asymmetric alkylation of glycine derivatives

  Yong-Gang Wang; Keiji Maruoka

  ORGANIC PROCESS RESEARCH & DEVELOPMENT, May 2007, Peer-reviewed

  
• Ammonium Ions as Chiral Templates

  Takashi Ooi; Keiji Maruoka

  Enantioselective Organocatalysis: Reactions and Experimental Procedures, 12 Apr. 2007, Peer-reviewed

  
• Aliphatic and Aromatic Claisen Rearrangement

  Hayato Ichikawa; Keiji Maruoka

  The Claisen Rearrangement: Methods and Applications, 15 Mar. 2007, Peer-reviewed

  
• Design of simple, yet very active chiral phase transfer catalysts for practical amino acid synthesis

  Keiji Maruoka

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2007, Peer-reviewed

  
• Effects of aromatic substituents on binaphthyl-based chiral spiro-type ammonium salts in asymmetric phase-transfer reactions

  Taichi Kano; Quan Lan; Xisheng Wang; Keiji Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Mar. 2007, Peer-reviewed

  
• Catalytic asymmetric rearrangement of alpha,alpha-disubstituted alpha-siloxy aldehydes to optically active acyloins using axially chiral organoaluminum lewis acids

  Takashi Ooi; Kohsuke Ohmatsu; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2007, Peer-reviewed

  
• New, chiral phase transfer catalysts for effecting asymmetric conjugate additions of alpha-alkyl-alpha-cyanoacetates to acetylenic esters

  Xisheng Wang; Masanori Kitamura; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2007, Peer-reviewed

  
• Advantage of in situ generation of N-arylsulfonyl imines from alpha-amide sulfones in the phase-transfer-catalyzed asymmetric Strecker reaction

  Takashi Ooi; Yukitaka Uematsu; Jun Fujimoto; Kazuhiro Fukumoto; Keiji Maruoka

  TETRAHEDRON LETTERS, Feb. 2007, Peer-reviewed

  
• Development and applications of C-2-symmetric, chiral, phase-transfer catalysts

  Takashi Ooi; Keiji Maruoka

  ALDRICHIMICA ACTA, 2007, Peer-reviewed

  
• Development and applications of C₂-symmetric, chiral, phase-transfer catalysts

  T. Ooi; K. Maruoka

  Aldrichimica Acta, 2007, Peer-reviewed

  
• Construction of stereodefined 1,1,2,2-tetrasubstituted cyclopropanes by acid catalyzed reaction of aryldiazoacetates and alpha-substituted acroleins

  Takuya Hashimoto; Yuki Naganawa; Taichi Kano; Keiji Maruoka

  CHEMICAL COMMUNICATIONS, 2007, Peer-reviewed

  
• Design of binaphthyl-modified symmetrical chiral phase-transfer catalysts: Substituent effect of 4,4 ',6,6 '-positions of binaphthyl rings in the asymmetric alkylation of a glycine derivative

  Seiji Shirakawa; Mitsuhiro Ueda; Youhei Tanaka; Takuya Hashimoto; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, 2007, Peer-reviewed

  
• exo-selective asymmetric Diels-Alder reaction catalyzed by diamine salts as organocatalysts

  Taichi Kano; Youhei Tanaka; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, 2007, Peer-reviewed

  
• Recent advances in asymmetric phase-transfer catalysis

  Takashi Ooi; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, Peer-reviewed

  
• syn-selective and enantioselective direct cross-aldol reactions between aldehydes catalyzed by an axially chiral amino sulfonamide

  Taichi Kano; Yukako Yamaguchi; Youhei Tanaka; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, Peer-reviewed

  
• Design of C-2-symmetric chiral phase-transfer catalysts for practical asymmetric synthesis

  Keiji Maruoka

  CHIMIA, 2007, Peer-reviewed

  
• Design of chiral organocatalysts for practical asymmetric synthesis of amino acid derivatives

  Keiji Maruoka; Takashi Ooi; Taichi Kano

  CHEMICAL COMMUNICATIONS, 2007, Peer-reviewed

  
• Asymmetric phase-transfer catalysis of homo- and heterochiral quaternary ammonium salts: development and application of conformationally flexible chiral phase-transfer catalysts

  Takashi Ooi; Yukitaka Uematsu; Minoru Kameda; Keiji Maruoka

  TETRAHEDRON, Dec. 2006, Peer-reviewed

  
• Design of a C-2-symmetric chiral pyrrolidine-based amino sulfonamide: application to anti-selective direct asymmetric Mannich reactions

  Taichi Kano; Yoshio Hato; Keiji Maruoka

  TETRAHEDRON LETTERS, Nov. 2006, Peer-reviewed

  
• Synthesis of a biphenyl-based axially chiral amino acid as a highly efficient catalyst for the direct asymmetric aldol reaction

  Taichi Kano; Osamu Tokuda; Keiji Maruoka

  TETRAHEDRON LETTERS, Oct. 2006, Peer-reviewed

  
• ORGN 297-Designer chiral phase transfer catalysts for practical asymmetric synthesis

  Keiji Maruoka

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006, Peer-reviewed

  
• Asymmetric synthesis of alpha-acyl-gamma-butyrolactones possessing all-carbon quaternary stereocenters by phase-transfer-catalyzed alkylation

  Takashi Ooi; Takashi Miki; Kazuhiro Fukumoto; Keiji Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Aug. 2006, Peer-reviewed

  
• Design of a binaphthyl-based axially chiral amino acid as an organocatalyst for direct asymmetric aldol reactions

  Taichi Kano; Osamu Tokuda; Jun Takai; Keiji Maruoka

  CHEMISTRY-AN ASIAN JOURNAL, Jul. 2006, Peer-reviewed

  
• Highly efficient trialkylsilylcyanation of aldehydes, ketones and imines catalyzed by a nucleophilic N-heterocyclic carbene

  Taichi Kano; Kouji Sasaki; Teppei Konishi; Haruka Mii; Keiji Maruoka

  TETRAHEDRON LETTERS, Jul. 2006, Peer-reviewed

  
• exo-Selective asymmetric Diels-Alder reaction catalyzed by diamine salts as organocatalysts

  Taichi Kano; Youhei Tanaka; Keiji Maruoka

  ORGANIC LETTERS, Jun. 2006, Peer-reviewed

  
• Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst

  Taichi Kano; Mitsuhiro Ueda; Jun Takai; Keiji Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2006, Peer-reviewed

  
• Organocatalytic oxy-Michael addition of alcohols to alpha,beta-unsaturated aldehydes

  T Kano; Y Tanaka; K Maruoka

  TETRAHEDRON LETTERS, May 2006, Peer-reviewed

  
• Phase-Transfer Catalysis

  Takashi Ooi; Keiji Maruoka

  Quaternary Stereocenters: Challenges and Solutions for Organic Synthesis, 05 Apr. 2006, Peer-reviewed

  
• Asymmetric Strecker reaction of aldimines using aqueous potassium cyanide by phase-transfer catalysis of chiral quaternary ammonium salts with a tetranaphthyl backbone

  T Ooi; Y Uematsu; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2006, Peer-reviewed

  
• Highly enantioselective monoalkylation of p-chlorobenzaldehyde imine of glycine tert-butyl ester under mild phase-transfer conditions

  T Ooi; Y Arimura; Y Hiraiwa; LM Yuan; T Kano; T Inoue; J Matsumoto; K Maruoka

  TETRAHEDRON-ASYMMETRY, Feb. 2006, Peer-reviewed

  
• Enantioselective 1,3-dipolar cycloaddition reaction between diazoacetates and alpha-substituted acroleins: Total synthesis of manzacidin A

  T Kano; T Hashimoto; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2006, Peer-reviewed

  
• Design of chiral tin(IV) aryloxide as a mild Lewis acid catalyst for enantioselective Diels-Alder reaction

  T Kano; T Konishi; S Konishi; K Maruoka

  TETRAHEDRON LETTERS, Feb. 2006, Peer-reviewed

  
• Highly diastereo- and enantioselective formal conjugate addition of nitroalkanes to nitroalkenes by chiral ammonium bifluoride catalysis

  Takashi Ooi; Saki Takada; Kanae Doda; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

  
• Construction of enantiomerically enriched tertiary alpha-hydroxycarboxylic acid derivatives by phase-transfer-catalyzed asymmetric alkylation of diaryloxazolidin-2,4-diones

  Takashi Ooi; Kazuhiro Fukumoto; Keiji Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

  
• Asymmetric Michael addition of silyl nitronates to cyclic alpha,beta-unsaturated ketones catalyzed by chiral quaternary ammonium bifluorides: isolation and selective functionalization of enol silyl ethers of optically active gamma-nitro ketones

  T Ooi; K Doda; S Takada; K Maruoka

  TETRAHEDRON LETTERS, Jan. 2006, Peer-reviewed

  
• Convenient preparation of highly active phase-transfer catalyst for catalytic asymmetric synthesis of alpha-alkyl- and alpha,alpha-dialkyl-alpha-amino acids: application to the short asymmetric synthesis of BIRT-377

  ZF Han; Y Yamaguchi; M Kitamura; K Maruoka

  TETRAHEDRON LETTERS, Dec. 2005, Peer-reviewed

  
• anti-Selective direct asymmetric Mannich reactions catalyzed by axially chiral amino sulfonamide as an organocatalyst

  T Kano; Y Yamaguchi; O Tokuda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2005, Peer-reviewed

  
• N-spiro chiral quaternary ammonium bromide catalyzed diastereo- and enantioselective conjugate addition of nitroalkanes to cyclic alpha,beta-unsaturated ketones under phase-transfer conditions

  T Ooi; S Takada; S Fujioka; K Maruoka

  ORGANIC LETTERS, Nov. 2005, Peer-reviewed

  
• A practical synthesis of (S)-2-Cyclohexyl-2-phenylglycolic acid via organocatalytic asymmetric construction of a tetrasubstituted carbon center

  O Tokuda; T Kano; WG Gao; T Ikemoto; K Maruoka

  ORGANIC LETTERS, Oct. 2005, Peer-reviewed

  
• Asymmetric 1,3-dipolar cycloaddition reaction of nitrones and acrolein with a bis-titanium catalyst as chiral lewis acid

  T Kano; T Hashimoto; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2005, Peer-reviewed

  
• Design of next-generation chiral acid-base catalysts and application to fine organic synthesis

  K Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Jul. 2005, Peer-reviewed

  
• Importance of chiral phase-transfer catalysts with dual functions in obtaining high enantioselectivity in the Michael reaction of malonates and chalcone derivatives

  T Ooi; D Ohara; K Fukumoto; K Maruoka

  ORGANIC LETTERS, Jul. 2005, Peer-reviewed

  
• Chiral designer phase-transfer catalysts for practical asymmetric synthesis

  K Maruoka

  PURE AND APPLIED CHEMISTRY, Jul. 2005, Peer-reviewed

  
• Highly enantioselective phase-transfer-catalyzed alkylation of protected alpha-amino acid amides toward practical asymmetric synthesis of vicinal diamines, alpha-amino ketones, and alpha-amino alcohols

  T Ooi; M Takeuchi; D Kato; Y Uematsu; E Tayama; D Sakai; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2005, Peer-reviewed

  
• Enantioselective acylation of secondary alcohols catalyzed by chiral N-heterocyclic carbenes

  T Kano; K Sasaki; K Maruoka

  ORGANIC LETTERS, Mar. 2005, Peer-reviewed

  
• Powerful chiral phase-transfer catalysts for the asymmetric synthesis of alpha-alkyl- and alpha,alpha,-dialkyl-alpha-amino acids

  M Kitamra; S Shirakawa; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2005, Peer-reviewed

  
• A case of Coats' disease in a low-birth-weight infant

  K Maruoka; M Yamamoto; H Fujita; Y Tahara; T Ishibashi

  OPHTHALMOLOGICA, 2005, Peer-reviewed

  
• Asymmetric synthesis of functionalized aza-cyclic amino acids with quaternary stereocenters by a phase-transfer-catalyzed alkylation strategy

  T Ooi; T Miki; K Maruoka

  ORGANIC LETTERS, Jan. 2005, Peer-reviewed

  
• Dramatic rate enhancement of asymmetric phase-transfer-catalyzed alkylations

  S Shirakawa; K Yamamoto; M Kitamura; T Ooi; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, Peer-reviewed

  
• Design of an axially chiral amino acid with a binaphthyl backbone as an organocatalyst for a direct asymmetric aldol reaction

  T Kano; J Takai; O Tokuda; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, Peer-reviewed

  
• Organoaluminum-mediated selective 1,2-rearrangement of gamma,gamma-disubstituted gamma-amino alpha,beta-unsaturated carbonyl compounds leading to unsymmetrically substituted pyrroles

  T Ooi; K Ohmatsu; H Ishii; A Saito; K Maruoka

  TETRAHEDRON LETTERS, Dec. 2004, Peer-reviewed

  
• Highly enantioselective conjugate addition of nitroalkanes to alkylidenemalonates using efficient phase-transfer catalysis of N-spiro chiral ammonium bromides

  T Ooi; S Fujioka; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2004, Peer-reviewed

  
• anti-Selective asymmetric synthesis of beta-hydroxy-alpha-amino acid esters by the in situ generated chiral quaternary ammonium fluoride-catalyzed Mukaiyama-type aldol reaction

  T Ooi; M Taniguchi; K Doda; K Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Aug. 2004, Peer-reviewed

  
• anti-Selective asymmetric synthesis of beta-hydroxy-alpha-amino acid esters by the in situ generated chiral quaternary ammonium fluoride-catalyzed Mukaiyama-type aldol reaction

  T Ooi; M Taniguchi; K Doda; K Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Aug. 2004, Peer-reviewed

  
• Asymmetric organocatalysis of structurally well-defined chiral quaternary ammonium fluorides

  T Ooi; K Maruoka

  ACCOUNTS OF CHEMICAL RESEARCH, Aug. 2004, Peer-reviewed

  
• Development of highly diastereo- and enantioselective direct asymmetric aldol reaction of a glycinate Schiff base with aldehydes catalyzed by chiral quaternary ammonium salts

  T Ooi; M Kameda; M Taniguchi; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2004, Peer-reviewed

  
• Evaluation of the relationship between the catalyst structure and regio- as well as stereoselectivity in the chiral ammonium bifluoride-catalyzed asymmetric addition of silyl nitronates to alpha,beta-unsaturated aldehydes

  T Ooi; K Morimoto; K Doda; K Maruoka

  CHEMISTRY LETTERS, Jul. 2004, Peer-reviewed

  
• Catalytic asymmetric synthesis of a nitrogen analogue of dialkyl tartrate by direct Mannich reaction under phase-transfer conditions

  T Ooi; M Kameda; J Fujii; K Maruoka

  ORGANIC LETTERS, Jul. 2004, Peer-reviewed

  
• Design of new chiral phase-transfer catalysts with dual functions for highly enantioselective epoxidation of alpha,beta-unsaturated ketones

  T Ooi; D Ohara; M Tamura; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2004, Peer-reviewed

  
• Efficient asymmetric catalysis of chiral organoaluminum complex for enantioselective ene reactions of aldehydes

  T Ooi; K Ohmatsu; D Uraguchi; K Maruoka

  TETRAHEDRON LETTERS, May 2004, Peer-reviewed

  
• Development of a recyclable fluorous chiral phase-transfer catalyst: Application to the catalytic asymmetric synthesis of alpha-amino acids

  S Shirakawa; Y Tanaka; K Maruoka

  ORGANIC LETTERS, Apr. 2004, Peer-reviewed

  
• Design of new polyamine-based chiral phase-transfer catalysts for the enantioselective synthesis of phenylalanine

  T Kano; S Konishi; S Shirakawa; K Maruoka

  TETRAHEDRON-ASYMMETRY, Apr. 2004, Peer-reviewed

  
• (2,7-disubstituted-1,8-biphenylenedioxy)bis(dimethylaluminum) as bidentate organoaluminum Lewis acids: Elucidation and synthetic utility of the double electrophilic activation phenomenon

  T Ooi; M Takahashi; M Yamada; E Tayama; K Omoto; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2004, Peer-reviewed

  
• Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: its synthetic advantage

  T Ooi; Y Uematsu; K Maruoka

  TETRAHEDRON LETTERS, Feb. 2004, Peer-reviewed

  
• Meerwein-Ponndorf-Verley alkynylation of aldehydes: Essential modification of aluminium alkoxides for rate acceleration and asymmetric synthesis

  T Ooi; T Miura; K Ohmatsu; A Saito; K Maruoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, Peer-reviewed

  
• Enantioselective synthesis of alpha-amino acids by chiral phase-transfer catalysis

  T Ooi; K Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Dec. 2003, Peer-reviewed

  
• A new N-spiro C-2-symmetric chiral quaternary ammonium bromide consisting of 4,6-disubstituted biphenyl subunit as an efficient chiral phase-transfer catalyst

  T Ooi; Y Kubota; K Maruoka

  SYNLETT, Sep. 2003, Peer-reviewed

  
• A scalable synthesis of (R)-3,5-dihydro-4H-dinaphth[2,1-c : 12-e]azepine

  M Ikunaka; K Maruoka; Y Okuda; T Ooi

  ORGANIC PROCESS RESEARCH & DEVELOPMENT, Sep. 2003, Peer-reviewed

  
• Catalytic asymmetric allylation of aldehydes and related reactions with bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide as a mu-oxo-type chiral Lewis acid

  H Hanawa; D Uraguchi; S Konishi; T Hashimoto; K Maruoka

  CHEMISTRY-A EUROPEAN JOURNAL, Sep. 2003, Peer-reviewed

  
• Fluorotetraphenylbismuth: A new reagent for efficient regioselective alpha-phenylation of carbonyl compounds

  T Ooi; R Goto; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2003, Peer-reviewed

  
• Enantioselective amino acid synthesis by chiral phase-transfer catalysis

  K Maruoka; T Ooi

  CHEMICAL REVIEWS, Aug. 2003, Peer-reviewed

  
• Highly enantioselective Michael addition of silyl nitronates to alpha,beta-unsaturated aldehydes catalyzed by designer chiral ammonium bifluorides: Efficient access to optically active gamma-nitro aldehydes and their enol silyl ethers

  T Ooi; K Doda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2003, Peer-reviewed

  
• Symmetrical 4,4 ',6,6 '-tetraarylbinaphthyl-substituted ammonium bromide as a new, chiral phase-transfer catalyst

  T Hashimoto; Y Tanaka; K Maruoka

  TETRAHEDRON-ASYMMETRY, Jun. 2003, Peer-reviewed

  
• Catalytic asymmetric methallylation and propargylation of aldehydes with bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide

  S Konishi; H Hanawa; K Maruoka

  TETRAHEDRON-ASYMMETRY, Jun. 2003, Peer-reviewed

  
• New, improved procedure for the synthesis of structurally diverse N-spiro C-2-symmetric chiral quaternary ammonium bromides

  T Ooi; Y Uematsu; K Maruoka

  JOURNAL OF ORGANIC CHEMISTRY, May 2003, Peer-reviewed

  
• Design of N-spiro C-2-symmetric chiral quaternary ammonium bromides as novel chiral phase-transfer catalysts: Synthesis and application to practical asymmetric synthesis of alpha-amino acids

  T Ooi; M Kameda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2003, Peer-reviewed

  
• Substituent effect of binaphthyl-modified spiro-type chiral phase-transfer catalysts

  T Hashimoto; K Maruoka

  TETRAHEDRON LETTERS, Apr. 2003, Peer-reviewed

  
• Isopropoxyaluminum 1,1 '-biphenyl-2-oxy-2 '-perfluorooctanesulfonamide as a catalyst for Tishchenko reaction

  T Ooi; K Ohmatsu; K Sasaki; T Miura; K Maruoka

  TETRAHEDRON LETTERS, Apr. 2003, Peer-reviewed

  
• Asymmetric skeletal rearrangement of symmetrically alpha,alpha-disubstituted alpha-amino aldehydes: A new entry to optically active alpha-hydroxy ketones

  T Ooi; A Saito; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2003, Peer-reviewed

  
• Designer chiral quaternary ammonium bifluorides as an efficient catalyst for asymmetric nitroaldol reaction of silyl nitronates with aromatic aldehydes

  T Ooi; K Doda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2003, Peer-reviewed

  
• Bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide as a mu-oxo-type chiral Lewis acid: Application to catalytic asymmetric allylation of aldehydes

  H Hanawa; T Hashimoto; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2003, Peer-reviewed

  
• Highly enantioselective construction of quaternary stereocenters on beta-keto esters by phase-transfer catalytic asymmetric alkylation and Michael reaction (vol 42, pg 3796, 2003)

  K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• Bowl-shaped [tris(2,6-diphenylbenzyl)siloxy]dimethylaluminum catalyst for effecting Tishchenko reaction

  S Shirakawa; J Takai; K Sasaki; T Miura; K Maruoka

  HETEROCYCLES, Jan. 2003, Peer-reviewed

  
• Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives

  T Ooi; D Sakai; M Takeuchi; E Tayama; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• Highly enantioselective construction of quaternary stereocenters on beta-keto esters by phase-transfer catalytic asymmetric alkylation and Michael reaction

  T Ooi; T Miki; M Taniguchi; M Shiraishi; M Takeuchi; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• Synthetic utility of bowl-shaped tris(2,6-diphenylbenzyl)silyl glyoxylate as a stable glyoxylate: application to highly diastereoselective aldol reactions

  S Shirakawa; K Maruoka

  TETRAHEDRON LETTERS, Jan. 2003, Peer-reviewed

  
• Highly stereoselective N-terminal functionalization of small peptides by chiral phase-transfer catalysis

  T Ooi; E Tayama; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• Catalytic enantioselective allylation of ketones with novel chiral bis-titanium(IV) catalyst

  S Kii; K Maruoka

  CHIRALITY, Jan. 2003, Peer-reviewed

  
• Activation of ether functionality of allyl vinyl ethers by chiral bis(organoaluminum) Lewis acids: application to asymmetric Claisen rearrangement

  E Tayama; A Saito; T Ooi; K Maruoka

  TETRAHEDRON, Oct. 2002, Peer-reviewed

  
• Practical Oppenauer (OPP) oxidation of alcohols with a modified aluminum catalyst

  T Ooi; H Otsuka; T Miura; H Ichikawa; K Maruoka

  ORGANIC LETTERS, Aug. 2002, Peer-reviewed

  
• Asymmetric induction in the Neber rearrangement of simple ketoxime sulfonates under phase-transfer conditions: Experimental evidence for the participation of an anionic pathway

  T Ooi; M Takahashi; K Doda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2002, Peer-reviewed

  
• Catalytic, enantioselective hetero-Diels-Alder reaction with novel, chiral bis-titanium(IV) catalyst

  S Kii; T Hashimoto; K Maruoka

  SYNLETT, Jun. 2002, Peer-reviewed

  
• Evaluation of the efficiency of the chiral quaternary ammonium salt beta-Np-NAS-Br in the organic-aqueous phase-transfer alkylation of a protected glycine derivative

  T Ooi; Y Uematsu; K Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, May 2002, Peer-reviewed

  
• Unusually stable silyl ketones with bowl-shaped tris(2,6-diphenylbenzyl)silyl group for various nucleophilic attacks and alpha-deprotonation

  S Shirakawa; N Komatsu; A Iwasaki; K Maruoka

  SYNLETT, Apr. 2002, Peer-reviewed

  
• Chemoselective reduction of saturated aldehydes and ketones over unsaturated carbonyls with bowl-shaped tris(2,6-diphenylbenzyl)tin hydride

  K Sasaki; N Komatsu; S Shirakawa; K Maruoka

  SYNLETT, Apr. 2002, Peer-reviewed

  
• Unusually stable silyl ketones with bowl-shaped tris(2,6-diphenylbenzyl)silyl group for various nucleophilic attacks and alpha-deprotonation

  S Shirakawa; N Komatsu; A Iwasaki; K Maruoka

  SYNLETT, Apr. 2002, Peer-reviewed

  
• Catalytic Meerwein-Ponndorf-Verley (MPV) and Oppenauer (OPP) reactions: Remarkable acceleration of the hydride transfer by powerful bidentate aluminum alkoxides

  T Ooi; T Miura; Y Itagaki; Ichikawa, I; K Maruoka

  SYNTHESIS-STUTTGART, Feb. 2002, Peer-reviewed

  
• A highly chemoselective Mukaiyama aldol reaction of saturated aldehyde over unsaturated aldehyde with enol tris(2,6-diphenylbenzyl)silyl ether

  S Shirakawa; K Maruoka

  TETRAHEDRON LETTERS, Feb. 2002, Peer-reviewed

  
• Prospective evaluation of suspected stenoocclusive disease of the intracranial artery: Combined MR angiography and CT angiography compared with digital subtraction angiography

  T Hirai; Y Korogi; K Ono; M Nagano; K Maruoka; S Uemura; M Takahashi

  AMERICAN JOURNAL OF NEURORADIOLOGY, Jan. 2002, Peer-reviewed

  
• Practical approach for catalytic asymmetric allylation of aldehydes with a chiral bidentate titanium(IV) complex (vol 42, pg 1935, 2001)

  S Kii; K Maruoka

  TETRAHEDRON LETTERS, Jan. 2002, Peer-reviewed

  
• Bis-zirconium and bis-hafnium catalysts for the strong activation of carbonyl substrates (vol 41, pg 5543, 2000)

  H Hanawa; S Kii; N Asao; K Maruoka

  TETRAHEDRON LETTERS, Jan. 2002, Peer-reviewed

  
• Conformationally flexible, chiral quaternary ammonium bromides for asymmetric phase-transfer catalysis

  T Ooi; Y Uematsu; M Kameda; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, Peer-reviewed

  
• Direct asymmetric aldol reactions of glycine Schiff base with aldehydes catalyzed by chiral quaternary ammonium salts

  T Ooi; M Taniguchi; M Kameda; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, Peer-reviewed

  
• Bidentate Lewis acid catalysts in asymmetric synthesis

  K Maruoka

  PURE AND APPLIED CHEMISTRY, Jan. 2002, Peer-reviewed

  
• Esterification of carboxylic acids catalyzed by in situ generated tetraalkylammonium fluorides

  T Ooi; H Sugimoto; K Doda; K Maruoka

  TETRAHEDRON LETTERS, Dec. 2001, Peer-reviewed

  
• A convergent, homochiral bis(amino alcohol) for obtaining high enantioselectivity in the addition of diethylzinc to aldehydes

  T Ooi; A Saito; K Maruoka

  CHEMISTRY LETTERS, Nov. 2001, Peer-reviewed

  
• Design of new, chiral phase-transfer catalysts for practical, catalytic asymmetric synthesis

  K Maruoka

  JOURNAL OF FLUORINE CHEMISTRY, Nov. 2001, Peer-reviewed

  
• Erratum: Tris(2,6-diphenylbenzyl)amine (TDA) and tris(2,6-diphenylbenzyl)phosphine (TDP) with unique bowl-shaped structures: Synthetic application of functionalized TDA to chemoselective silylation of benzylic alcohols (Tetrahedron Letters (2001) 42 (5467

  M. Naiki; S. Shirakawa; K. Kon-i; Y. Kondo; K. Maruoka

  Tetrahedron Letters, 29 Oct. 2001, Peer-reviewed

  
• Concise, catalytic asymmetric synthesis of tetrahydroisoquinoline- and dihydroisoquinoline-3-carboxylic acid derivatives

  T Ooi; M Takeuchi; K Maruoka

  SYNTHESIS-STUTTGART, Aug. 2001, Peer-reviewed

  
• Tris(2,6-diphenylbenzyl)amine (TDA) and tris(2,6-diphenylbenzyl)phosphine (TDP) with unique bowl-shaped structures: synthetic application of functionalized TDA to chemoselective silylation of benzylic alcohols

  M Naiki; S Shirakawa; K Kon-i; Y Kondo; K Maruoka

  TETRAHEDRON LETTERS, Aug. 2001, Peer-reviewed

  
• Advantage of anaerobic conditions in the highly enantioselective synthesis of alpha,alpha-dialkyl-alpha-amino acids by chiral phase-transfer catalysis

  T Ooi; M Takeuchi; D Ohara; K Maruoka

  SYNLETT, Jul. 2001, Peer-reviewed

  
• Advantage of anaerobic conditions in the highly enantioselective synthesis of alpha,alpha-dialkyl-alpha-amino acids by chiral phase-transfer catalysis

  T Ooi; M Takeuchi; D Ohara; K Maruoka

  SYNLETT, Jul. 2001, Peer-reviewed

  
• o-(o-iodophenyl)phenylselenenyl ethers/t-BuLi system as an alkyllithium equivalent with structural variations

  T Ooi; D Sakai; M Takada; N Komatsu; K Maruoka

  SYNLETT, Jun. 2001, Peer-reviewed

  
• Distinct advantage of the in situ generation of quaternary ammonium fluorides under phase-transfer conditions toward catalytic asymmetric synthesis

  T Ooi; K Doda; K Maruoka

  ORGANIC LETTERS, May 2001, Peer-reviewed

  
• Utilization of o-[(E)-2-trimethylsilyl-2-iodovinyl]phenylthioderivatives as carbon radical precursors by anchimeric approach

  T Ooi; M Furuya; D Sakai; Y Hokke; K Maruoka

  SYNLETT, Apr. 2001, Peer-reviewed

  
• Bidentate Lewis acids for organic synthesis

  K Maruoka

  CATALYSIS TODAY, Mar. 2001, Peer-reviewed

  
• Practical approach for catalytic asymmetric allylation of aldehydes with a chiral bidentate titanium(IV) complex

  S Kii; K Maruoka

  TETRAHEDRON LETTERS, Mar. 2001, Peer-reviewed

  
• Facile conversion of trialkylsilyl esters to alkyl esters mediated by tetrabutylammonium fluoride trihydrate

  T Ooi; H Sugimoto; K Maruoka

  HETEROCYCLES, Feb. 2001, Peer-reviewed

  
• Rapid and mild generation of carbon radicals from o(o-iodophenyl)phenylthio derivatives by an anchimeric approach

  T Ooi; M Furuya; D Sakai; K Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Feb. 2001, Peer-reviewed

  
• Bowl-shaped tris(2,6-diphenylbenzyl)tin hydride: A unique reducing agent for radical and ionic chemistry

  K Sasaki; Y Kondo; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2001, Peer-reviewed

  
• Lewis acid control of asymmetric synthesis - Preface

  K Maruoka

  TETRAHEDRON, Jan. 2001, Peer-reviewed

  
• Zr(OBut)(4) as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes: development of new asymmetric cyanohydrin synthesis

  T Ooi; T Miura; K Takaya; H Ichikawa; K Maruoka

  TETRAHEDRON, Jan. 2001, Peer-reviewed

  
• Bowl-shaped tris(2,6-diphenylbenzyl)tin hydride: A unique reducing agent for radical and ionic chemistry

  K Sasaki; Y Kondo; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2001, Peer-reviewed

  
• Practical approach to the Meerwein-Ponndorf-Verley reduction of carbonyl substrates with new aluminum catalysts

  T Ooi; H Ichikawa; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2001, Peer-reviewed

  
• Remarkable template effect of a Lewis acid receptor in the intramolecular radical cyclization: control of reaction pathway as well as stereochemistry

  T Ooi; Y Hokke; E Tayama; K Maruoka

  TETRAHEDRON, Jan. 2001, Peer-reviewed

  
• New chiral bis-titanium(IV) catalyst with dibenzofuran spacer for catalytic asymmetric allylation of aldehydes and aryl ketones

  H Hanawa; S Kii; K Maruoka

  ADVANCED SYNTHESIS & CATALYSIS, Jan. 2001, Peer-reviewed

  
• Dramatic rate enhancement by ultrasonic irradiation in liquid-liquid phase-transfer catalytic reactions

  T Ooi; E Tayama; K Doda; M Takeuchi; K Maruoka

  SYNLETT, Oct. 2000, Peer-reviewed

  
• Facile synthesis of L-Dopa tert-butyl cater by catalytic enantioselective phase-transfer alkylation

  T Ooi; M Kameda; H Tannai; K Maruoka

  TETRAHEDRON LETTERS, Oct. 2000, Peer-reviewed

  
• Tris(2,6-diphenylbenzyl)silyl group as a new and highly effective protector for carboxylic acids: Unusual behavior of such carboxylic esters toward common nucleophiles and bases

  A Iwasaki; Y Kondo; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2000, Peer-reviewed

  
• Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

  T Ooi; K Takaya; T Miura; H Ichikawa; K Maruoka

  SYNLETT, Aug. 2000, Peer-reviewed

  
• Unique synthetic utility of BF3 center dot OEt2 in the highly diastereoselective reduction of hydroxy carbonyl and dicarbonyl substrates

  T Ooi; D Uraguchi; J Morikawa; K Maruoka

  ORGANIC LETTERS, Jul. 2000, Peer-reviewed

  
• Dramatic enhancement of reactivity of organosilicon compounds induced by complexation of bis(allyl)silanes with fluoride ion

  A Shibato; Y Itagaki; E Tayama; Y Hokke; N Asao; K Maruoka

  TETRAHEDRON, Jul. 2000, Peer-reviewed

  
• Bis-zirconium and bis-hafnium catalysts for the strong activation of carbonyl substrates

  H Hanawa; S Kii; N Asao; K Maruoka

  TETRAHEDRON LETTERS, Jul. 2000, Peer-reviewed

  
• Practical catalytic enantioselective synthesis of alpha,alpha-dialkyl-alpha-amino acids by chiral phase-transfer catalysis

  T Ooi; M Takeuchi; M Kameda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2000, Peer-reviewed

  
• Efficient catalytic procedure for etherification of alcohols with MeAl(NTf2)(2)

  T Ooi; H Ichikawa; Y Itagaki; K Maruoka

  HETEROCYCLES, Feb. 2000, Peer-reviewed

  
• "Amphiphilic" cleavage of gamma-stannyl ketones with ATPH/RLi: Application to enone fragmentation by the conjugate addition - Cleavage sequence

  Y Kondo; K Kon-i; A Iwasaki; T Ooi; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, Peer-reviewed

  
• Zr(OBut)(4) as a new promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes

  T Ooi; K Takaya; T Miura; K Maruoka

  SYNLETT, Jan. 2000, Peer-reviewed

  
• Chemistry of chelate-type hypervalent boron and aluminum: Utilization for selective organic synthesis

  D Uraguchi; T Ooi; K Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Jan. 2000, Peer-reviewed

  
• \\'Amphiphilic\\' cleavage of γ-stannyl ketones with ATPH/RLi: Application to enone fragmentation by the conjugate addition - Cleavage sequence

  Y. Kondo; K. Kon-i; A. Iwasaki; T. Ooi; K. Maruoka

  Angewandte Chemie - International Edition, 2000, Peer-reviewed

  
• Highly efficient amphiphilic cleavage of gamma-iodo carbonyl substrates with aluminum tris(2,6-diphenylphenoxide)/t-BuLi system

  Y Kondo; K Kon; T Ooi; K Maruoka

  TETRAHEDRON LETTERS, Dec. 1999, Peer-reviewed

  
• Double coordination ability of bis(dimethylaluminum) sulfate toward carbonyl substrates

  H Hanawa; N Maekawara; K Maruoka

  TETRAHEDRON LETTERS, Nov. 1999, Peer-reviewed

  
• Catalytic, high-speed Tishchenko reaction using (2,7-dimethyl-1,8-biphenylenedioxy)bis(diisopropoxyaluminum) as a powerful bidentate catalyst

  T Ooi; T Miura; K Takaya; K Maruoka

  TETRAHEDRON LETTERS, Oct. 1999, Peer-reviewed

  
• Remarkable catalytic activity of Me3Ga in the alkylation of hetero-substituted epoxides with alkynyllithiums

  T Ooi; J Morikawa; H Ichikawa; K Maruoka

  TETRAHEDRON LETTERS, Aug. 1999, Peer-reviewed

  
• Double coordination and activation ability of methylalumoxane (MAO) for hetero functionality: Pivotal role as polymerization cocatalyst

  H Hanawa; N Abe; K Maruoka

  TETRAHEDRON LETTERS, Jul. 1999, Peer-reviewed

  
• Highly efficient alkylation of epoxides with R3Al/H2O systems based on the double activation of epoxy oxygens

  N Abe; H Hanawa; K Maruoka; M Sasaki; M Miyashita

  TETRAHEDRON LETTERS, Jul. 1999, Peer-reviewed

  
• Molecular design of a C-2-symmetric chiral phase-transfer catalyst for practical asymmetric synthesis of alpha-amino acids

  T Ooi; M Kameda; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 1999, Peer-reviewed

  
• Efficient synthesis of aromatic sec-amides from esters: Synthetic utility of bislithium amides

  T Ooi; E Tayama; M Yamada; K Maruoka

  SYNLETT, Jun. 1999, Peer-reviewed

  
• Pentacoordinate organoaluminum chemistry: Catalytic efficiency of Me3Al in the epoxide cleavage with alkynyllithiums

  T Ooi; N Kagoshima; H Ichikawa; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 1999, Peer-reviewed

  
• Hypercoordination of aluminum: Evidence for the implication of pentacoordinate complexes in the R2AlCl-promoted reduction of alkoxycarbonyl substrates

  T Ooi; J Morikawa; D Uraguchi; K Maruoka

  TETRAHEDRON LETTERS, Apr. 1999, Peer-reviewed

  
• The synthetic utility of the hypercoordination of boron and aluminum

  K Maruoka; T Ooi

  CHEMISTRY-A EUROPEAN JOURNAL, Mar. 1999, Peer-reviewed

  
• Unique property of copper(I) chloride as a radical initiator as well as a Lewis acid: Application to CuCl-catalyzed aldol reaction of alpha,beta-unsaturated ketones with Bu3SnH

  T Ooi; K Doda; D Sakai; K Maruoka

  TETRAHEDRON LETTERS, Mar. 1999, Peer-reviewed

  
• Simultaneous functional group manipulation in the Meerwein-Ponndorf-Verley reduction process catalyzed by bidentate aluminum reagent

  T Ooi; Y Itagaki; T Miura; K Maruoka

  TETRAHEDRON LETTERS, Mar. 1999, Peer-reviewed

  
• The synthetic utility of the hypercoordination of boron and aluminum

  K. Maruoka; T. Ooi

  Chemistry - A European Journal, 1999, Peer-reviewed

  
• Pentacoordinate vs. tetracoordinate complexation for alkoxycarbonyl compounds with dialkylboron triflates and trifluoroacetates?

  T Ooi; D Uraguchi; K Maruoka

  TETRAHEDRON LETTERS, Oct. 1998, Peer-reviewed

  
• First Meerwein-Ponndorf-Verley alkynylation: Nonorganometallic way for carbonyl alkylations

  T Ooi; T Miura; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 1998, Peer-reviewed

  
• Highly efficient, catalytic Meerwein-Ponndorf-Verley reduction with a novel bidentate aluminum catalyst

  T Ooi; T Miura; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 1998, Peer-reviewed

  
• Organoaluminum-promoted selective addition to fluorinated carbonyl compounds via pentacoordinate trialkylaluminum complexes

  T Ooi; N Kagoshima; D Uraguchi; K Maruoka

  TETRAHEDRON LETTERS, Sep. 1998, Peer-reviewed

  
• Highly efficient, catalytic Meerwein-Ponndorf-Verley reduction with a novel bidentate aluminum catalyst

  T Ooi; T Miura; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 1998, Peer-reviewed

  
• Facile and selective alkylation of 3,3,3-trifluoropropene oxide (TFPO) with organoaluminum reagents via pentacoordinate trialkylaluminum complexes

  T Ooi; M Furuya; K Maruoka

  CHEMISTRY LETTERS, Aug. 1998, Peer-reviewed

  
• Hypercoordination of boron and aluminum: Synthetic utility as chelating Lewis acids

  T Ooi; D Uraguchi; N Kagoshima; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1998, Peer-reviewed

  
• Selective conjugate alkylation of alkyllithium nucleophiles to alpha,beta,gamma,delta-unsaturated aldehydes with functionalized Lewis acid receptors

  T Ooi; Y Kondo; K Kon-I; K Maruoka

  CHEMISTRY LETTERS, May 1998, Peer-reviewed

  
• Dilithium 2,2 '-methylenebis(4,6-di-tert-butylphenoxide) as a bidentate Lewis acid in organic synthesis

  T Ooi; A Saito; K Maruoka

  TETRAHEDRON LETTERS, May 1998, Peer-reviewed

  
• Simultaneous coordination and double activation phenomena of carbonyl and epoxy oxygens by bis-titanium reagent as a bidentate Lewis acid catalyst

  N Asao; S Kii; H Hanawa; K Maruoka

  TETRAHEDRON LETTERS, May 1998, Peer-reviewed

  
• o-bis(allyldimethylsilyl)benzene as a remarkably effective allylation agent for carbonyl compounds with Bu4NF catalyst

  N Asao; A Shibato; Y Itagaki; F Jourdan; K Maruoka

  TETRAHEDRON LETTERS, May 1998, Peer-reviewed

  
• High activation of carbonyl groups with bidentate Lewis acid catalysts

  T Ooi; N Asao; K Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, May 1998, Peer-reviewed

  
• Selective conjugate alkylation of alkyllithium nucleophiles to alpha,beta,gamma,delta-unsaturated aldehydes with functionalized Lewis acid receptors

  T Ooi; Y Kondo; K Kon-I; K Maruoka

  CHEMISTRY LETTERS, May 1998, Peer-reviewed

  
• Rate acceleration in nucleophilic alkylation of carbonyl compounds with a new template containing two metallic centers

  T Ooi; M Takahashi; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Apr. 1998, Peer-reviewed

  
• Protic solvent-promoted neutral allylation of aldehydes and ketones with 1,8-bis(allylstannyl)naphthalenes

  N Asao; N Abe; Z Tan; K Maruoka

  SYNLETT, Apr. 1998, Peer-reviewed

  
• Exceptionally bulky Lewis acidic reagent, MAD

  T Ooi; K Maruoka

  REVIEWS ON HETEROATOM CHEMISTRY, 1998, Peer-reviewed

  
• Remarkable Rate Acceleration of Nucleophilic Carbonyl Alkylation with a New Bimetallic Two-Center Template.

  丸岡 啓二

  Angew. Chem. Int. Ed. Engl.,37/6,835-837, 1998, Peer-reviewed

  
• Unprecedented encapsulation of carbonyl guest with designer Lewis acid receptor

  T Ooi; Y Kondo; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1998, Peer-reviewed

  
• 1,8-bis(allylstannyl)naphthalene derivatives as neutral allylation agents: Rate acceleration by chelation-induced Lewis acidity

  N Asao; PL Liu; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, Dec. 1997, Peer-reviewed

  
• Bidentate organoaluminum Lewis acid for selective activation of carbonyl over acetal functionality: Chemoselective functionalization

  T Ooi; E Tayama; M Takahashi; K Maruoka

  TETRAHEDRON LETTERS, Oct. 1997, Peer-reviewed

  
• Organoaluminum-catalyzed new alkylation of tert-alkyl fluorides: Synthetic utility of Al-F interaction

  T Ooi; D Uraguchi; N Kagoshima; K Maruoka

  TETRAHEDRON LETTERS, Aug. 1997, Peer-reviewed

  
• Regioselective Robinson annulation realized by the combined use of lithium enolates and aluminum tris(2,6-diphenylphenoxide) (ATPH)

  S Saito; Shimada, I; Y Takamori; M Tanaka; K Maruoka; H Yamamoto

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jul. 1997, Peer-reviewed

  
• Fluorine-assisted selective alkylation to fluorinated epoxides and carbonyl compounds: Implication of pentacoordinate trialkylaluminum complexes

  T Ooi; N Kagoshima; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1997, Peer-reviewed

  
• Remarkable template effect of a Lewis acidic receptor in intramolecular radical cyclizations

  T Ooi; Y Hokke; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, Jun. 1997, Peer-reviewed

  
• Evaluation of several fluorinated ATPH derivatives as functionalized Lewis acid receptors for conjugate alkylation to alpha,beta-unsaturated aldehydes with alkyllithium nucleophiles

  T Ooi; Y Kondo; T Miura; K Maruoka

  TETRAHEDRON LETTERS, Jun. 1997, Peer-reviewed

  
• Conjugate allylation to alpha,beta-unsaturated aldehydes with the new chemzyme p-F-ATPH

  T Ooi; Y Kondo; K Maruoka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, Jun. 1997, Peer-reviewed

  
• Conjugate allylation to alpha,beta-unsaturated aldehydes with amphiphilic alkylation system, ATPH/allylcerium reagents

  T Ooi; T Miura; Y Kondo; K Maruoka

  TETRAHEDRON LETTERS, Jun. 1997, Peer-reviewed

  
• Selective alkylation of ketones with a bulky aluminum reagent - The THF-TBSOTf system

  S Saito; M Ito; K Maruoka; H Yamamoto

  SYNLETT, Apr. 1997, Peer-reviewed

  
• Organoaluminum-promoted cyclization of olefinic epoxides. A new and stereoselective approach to cyclohexane frameworks

  N Murase; K Maruoka; T Ooi; H Yamamoto

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Mar. 1997, Peer-reviewed

  
• Organoaluminum-promoted rearrangement of epoxysilanes to alpha-silylaldehydes

  T Ooi; T Kiba; K Maruoka

  CHEMISTRY LETTERS, 1997, Peer-reviewed

  
• (2,7-dimethyl-1,8-biphenylenedioxy)bis(dimethyl-aluminum) as a bidentate Lewis acid: Its reactivity and selectivity in organic synthesis

  T Ooi; M Takahashi; K Maruoka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 1996, Peer-reviewed

  
• Novel anionic oligomerization by a new, sequential generation of organolithium compounds

  K Maruoka; M Oishi; H Yamamoto

  MACROMOLECULES, Apr. 1996, Peer-reviewed

  
• The catalytic Shapiro reaction

  K Maruoka; M Oishi; H Yamamoto

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1996, Peer-reviewed

  
• Exceptionally bulky Lewis acidic reagent, MAD

  T Ooi; K Maruoka

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Mar. 1996, Peer-reviewed

  
• 共役アルキル化反応の新展開 (1996年の化学-2-)

  丸岡 啓二

  化学, Feb. 1996, Peer-reviewed

  
• UNPRECEDENTED NUCLEOPHILIC-ADDITION OF ORGANOLITHIUMS TO AROMATIC-ALDEHYDES AND KETONES BY COMPLEXATION WITH ALUMINUM TRIS(2,6-DIPHENYLPHENOXIDE)

  K MARUOKA; M ITO; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1995, Peer-reviewed

  
• EVALUATION OF ALUMINUM TRIS(2,6-DI-TERT-BUTYL-4-METHYLPHENOXIDE) (ATD) AS A LEWIS-ACID RECEPTOR

  K MARUOKA; H IMOTO; H YAMAMOTO

  SYNLETT, Jul. 1995, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED CYCLOADDITION OF TRIALKYLSILYLKETENE WITH ALDEHYDES - A NEW, STEREOSELECTIVE APPROACH TO CIS-2-OXETANONES AND 2(Z)-ALKENOIC ACIDS

  AB CONCEPCION; K MARUOKA; H YAMAMOTO

  TETRAHEDRON, Apr. 1995, Peer-reviewed

  
• REARRANGEMENT OF TRANS-STILBENE OXIDE TO DIPHENYLACETALDEHYDE WITH CATALYTIC METHYLALUMINUM BIS(4-BROMO-2,6-DI-TERT-BUTYLPHENOXIDE) - (OXIRANE, 2,3-DIPHENYL-, TRANS- TO BENZENEACETALDEHYDE, ALPHA-PHENYL-)

  T OOI; K MARUOKA; H YAMAMOTO

  ORGANIC SYNTHESES, VOL 72, 1995, Peer-reviewed

  
• ALUMINUM TRIS(2,6-DIPHENYLPHENOXIDE) (ATPH) AS AN EFFICIENT AND SELECTIVE ACTIVATOR FOR INOUE POLYMERIZATION

  K MARUOKA; M AKAKURA; H YAMAMOTO

  SYNLETT, Jan. 1995, Peer-reviewed

  
• MOLECULAR DESIGN OF A CHIRAL LEWIS-ACID FOR THE ASYMMETRIC CLAISEN REARRANGEMENT

  K MARUOKA; S SAITO; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 1995, Peer-reviewed

  
• 新しいルイス酸型レセプターATPHを用いる選択的有機合成

  丸岡 啓二

  化学,50/3,58, 1995, Peer-reviewed

  
• EXO-SELECTIVE DIELS-ALDER REACTION-BASED ON A MOLECULAR RECOGNITION APPROACH

  K MARUOKA; H IMOTO; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 1994, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED HOMOLOGATION OF KETONES WITH DIAZOALKANES

  K MARUOKA; AB CONCEPCION; H YAMAMOTO

  JOURNAL OF ORGANIC CHEMISTRY, Aug. 1994, Peer-reviewed

  
• ASYMMETRIC DIELS-ALDER REACTION OF UNSYMMETRICAL MALEATES - A CHEMICAL ACCESS TO CHIRAL, UNSYMMETRICAL CIS-CYCLOHEXENE-1,2-DICARBOXYLATES

  K MARUOKA; M AKAKURA; S SAITO; T OOI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 1994, Peer-reviewed

  
• METHYLALUMINUM BIS(4-SUBSTITUTED-2,6-DI-TERT-BUTYLPHENOXIDE) AS AN EFFICIENT NONCHELATING LEWIS-ACID - APPLICATION TO ASYMMETRIC DIELS-ALDER REACTION AND DIASTEROSELECTIVE ALKYLATION TO ALKOXY CARBONYL SUBSTRATES

  K MARUOKA; M OISHI; K SHIOHARA; H YAMAMOTO

  TETRAHEDRON, Jul. 1994, Peer-reviewed

  
• VIRTUALLY COMPLETE BLOCKING OF ALPHA,BETA-UNSATURATED ALDEHYDE CARBONYLS BY COMPLEXATION WITH ALUMINUM TRIS(2,6-DIPHENYLPHENOXIDE)

  K MARUOKA; H IMOTO; S SAITO; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 1994, Peer-reviewed

  
• UNPRECEDENTED STEREOCHEMICAL CONTROL IN THE INTRAMOLECULAR ENE-REACTIONS OF DELTA,EPSILON-UNSATURATED ALDEHYDES USING EXCEPTIONALLY BULKY ORGANOALUMINUM REAGENTS - ELUCIDATION OF THE TRANSITION-STATE

  T OOI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON, May 1994, Peer-reviewed

  
• LEWIS ACID-PROMOTED SELECTIVE REARRANGEMENT OF TRISUBSTITUTED EPOXIDES TO ALDEHYDES OR KETONES

  K MARUOKA; N MURASE; R BUREAU; T OOI; H YAMAMOTO

  TETRAHEDRON, Mar. 1994, Peer-reviewed

  
• REGIOSELECTIVE FISCHER INDOLE SYNTHESIS MEDIATED BY ORGANOALUMINUM AMIDES

  K MARUOKA; M OISHI; H YAMAMOTO

  JOURNAL OF ORGANIC CHEMISTRY, Dec. 1993, Peer-reviewed

  
• REGIOSELECTIVE HYDROALUMINATION OF ALLENES AND THEIR SYNTHETIC APPLICATION

  S NAGAHARA; K MARUOKA; H YAMAMOTO

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Dec. 1993, Peer-reviewed

  
• STABILIZATION OF REACTIVE ALDEHYDES BY COMPLEXATION WITH METHYLALUMINUM BIS(2,6-DIPHENYLPHENOXIDE) AND THEIR SYNTHETIC APPLICATION

  K MARUOKA; AB CONCEPCION; N MURASE; M OISHI; N HIRAYAMA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 1993, Peer-reviewed

  
• CHIRAL HELICAL LEWIS-ACIDS FOR ASYMMETRIC DIELS-ALDER CATALYSTS

  K MARUOKA; N MURASE; H YAMAMOTO

  JOURNAL OF ORGANIC CHEMISTRY, May 1993, Peer-reviewed

  
• CHEMOSELECTIVE FUNCTIONALIZATION OF MORE HINDERED ALDEHYDE CARBONYLS WITH THE METHYLALUMINUM BIS(2,6-DIPHENYLPHENOXIDE)/ALKYLLITHIUM SYSTEM

  K MARUOKA; S SAITO; AB CONCEPCION; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 1993, Peer-reviewed

  
• エポキシドの選択的転位を機軸とする不斉アルドール合成

  丸岡 啓二

  化学,48/3,218-9, 1993, Peer-reviewed

  
• Designer Lewis Acid Based on Molecular Recognition

  丸岡 啓二

  Supramolecular Chemistry,2/2-3,111-21, 1993, Peer-reviewed

  
• PRACTICAL ASYMMETRIC-SYNTHESIS OF BOTH ERYTHRO AND THREO ALDOLS BASED ON THE MABR-PROMOTED SELECTIVE REARRANGEMENT OF ERYTHRO AND THREO EPOXY SILYL ETHERS - UNUSUAL EFFECT OF SILYL SUBSTITUENTS

  K MARUOKA; J SATO; H YAMAMOTO

  TETRAHEDRON, May 1992, Peer-reviewed

  
• MIGRATORY APTITUDE OF ALKYL SUBSTITUENTS IN THE MABR-PROMOTED EPOXIDE REARRANGEMENT

  K MARUOKA; T OOI; H YAMAMOTO

  TETRAHEDRON, Apr. 1992, Peer-reviewed

  
• Methylaluminum Bis(4-bromo-2, 6-di-┣DBtert(/)-┫DB-butylphenoxide) as a Key Reagent for Effecting α-┣DBprimary(/)-┫DB-Alkylation of Carbonyl Compounds

  丸岡 啓二

  Journal of the American Chemical Society,114/11,4422, 1992, Peer-reviewed

  
• Discrimination of Two Different Ester Carbonyls with MAD : Application to the Regio- and Stereocontrolled Diels-Alder Reaction of Unsymmetrical Fumarates

  丸岡 啓二

  Journal of the American Chemical Society,114/3,1089, 1992, Peer-reviewed

  
• A HIGHLY EFFICIENT SEPARATION OF STRUCTURALLY SIMILAR EPOXY SILYL ETHERS BY COMPLEXATION CHROMATOGRAPHY ON POLYMERIC ORGANOALUMINUM REAGENTS

  S NAGAHARA; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, Jan. 1992, Peer-reviewed

  
• ORGANOALUMINUM-CATALYZED REARRANGEMENT OF EPOXIDES - A FACILE ROUTE TO THE SYNTHESIS OF OPTICALLY-ACTIVE BETA-SILOXY ALDEHYDES

  K MARUOKA; T OOI; S NAGAHARA; H YAMAMOTO

  TETRAHEDRON, Aug. 1991, Peer-reviewed

  
• Practical Asymmetric Synthesis of Both Erythro and Threo Aldols: Unusual Effect of Silyl Groups

  Keiji Maruoka; Junko Sato; Hisashi Yamamoto

  Journal of the American Chemical Society, 01 Jul. 1991, Peer-reviewed

  
• ENANTIOSELECTIVE ACTIVATION OF ETHERS BY CHIRAL ORGANOALUMINUM REAGENTS - APPLICATION TO ASYMMETRIC CLAISEN REARRANGEMENT

  K MARUOKA; H BANNO; H YAMAMOTO

  TETRAHEDRON-ASYMMETRY, 1991, Peer-reviewed

  
• UNPRECEDENTED STEREOCHEMICAL CONTROL IN THE ORGANOALUMINUM-PROMOTED INTRAMOLECULAR ENE REACTIONS OF DELTA,EPSILON-UNSATURATED ALDEHYDES

  K MARUOKA; T OOI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 1990, Peer-reviewed

  
• STEREOSELECTIVE AND REGIOSELECTIVE ORGANIC TRANSFORMATIONS BASED ON MAIN GROUP ORGANOMETALLIC REAGENTS - APPLICATION TO THE STEREOCONTROLLED CLAISEN REARRANGEMENTS

  H YAMAMOTO; K MARUOKA

  PURE AND APPLIED CHEMISTRY, Oct. 1990, Peer-reviewed

  
• MOLECULAR RECOGNITION OF ETHERS WITH MODIFIED ORGANOALUMINUM REAGENTS

  K MARUOKA; S NAGAHARA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1990, Peer-reviewed

  
• Generation of Stable Formaldehyde-Organoaluminum Complexes and its Synthetic Utility

  丸岡 啓二

  Journal of the American Chemical Society,112/20, 1990, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED CLAISEN REARRANGEMENT OF ALLYL VINYL ETHERS

  K NONOSHITA; H BANNO; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 1990, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED REARRANGEMENT OF ALLYL PHENYL ETHERS

  K MARUOKA; J SATO; H BANNO; H YAMAMOTO

  TETRAHEDRON LETTERS, 1990, Peer-reviewed

  
• MOLECULAR RECOGNITION OF OXYGEN-CONTAINING SUBSTRATES WITH MAD

  K MARUOKA; S NAGAHARA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1990, Peer-reviewed

  
• A NEW PREPARATIVE METHOD FOR VARIOUS METAL ENOLATES

  K MARUOKA; N HIRAYAMA; H YAMAMOTO

  POLYHEDRON, 1990, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED REARRANGEMENT OF EPOXY SILYL ETHERS TO BETA-SILOXY ALDEHYDES

  K MARUOKA; T OOI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1989, Peer-reviewed

  
• LEWIS ACID CATALYST IN ORGANIC-SYNTHESIS

  H YAMAMOTO; K MARUOKA; K FURUTA

  ACID-BASE CATALYSIS, 1989, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED CLAISEN REARRANGEMENT OF BISALLYL VINYL ETHERS

  K MARUOKA; H BANNO; K NONOSHITA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1989, Peer-reviewed

  
• AN EFFICIENT, CATALYTIC PROCEDURE FOR EPOXIDE REARRANGEMENT

  K MARUOKA; S NAGAHARA; T OOI; H YAMAMOTO

  TETRAHEDRON LETTERS, 1989, Peer-reviewed

  
• GENERATION OF CHIRAL ORGANO-ALUMINUM REAGENT BY DISCRIMINATION OF THE RACEMATES WITH CHIRAL KETONE

  K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 1989, Peer-reviewed

  
• AMPHIPHILIC REACTIONS BY MEANS OF EXCEPTIONALLY BULKY ORGANO-ALUMINUM REAGENTS - RATIONAL APPROACH FOR OBTAINING UNUSUAL EQUATORIAL, ANTI-CRAM, AND 1,4 SELECTIVITY IN CARBONYL ALKYLATION

  K MARUOKA; T ITOH; M SAKURAI; K NONOSHITA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 1988, Peer-reviewed

  
• METHYLALUMINUM BIS(2,6-DI-TERT-BUTYL-4-METHYLPHENOXIDE) AS A PROTECTING GROUP FOR MULTIFUNCTIONAL MOLECULES - SYNTHETIC UTILITY IN SELECTIVE CARBONYL REDUCTIONS

  K MARUOKA; Y ARAKI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 1988, Peer-reviewed

  
• ASYMMETRIC ENE REACTION CATALYZED BY CHIRAL ORGANO-ALUMINUM REAGENT

  K MARUOKA; Y HOSHINO; T SHIRASAKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1988, Peer-reviewed

  
• CHEMOSELECTIVE CARBONYL ALKYLATION AND REDUCTION OF ALDEHYDES OR KETONES

  K MARUOKA; Y ARAKI; H YAMAMOTO

  TETRAHEDRON LETTERS, 1988, Peer-reviewed

  
• ASYMMETRIC HETERO-DIELS-ALDER REACTION CATALYZED BY CHIRAL ORGANO-ALUMINUM REAGENT

  K MARUOKA; T ITOH; T SHIRASAKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 1988, Peer-reviewed

  
• Tetrahedron report number 239. Organoaluminums in organic synthesis

  K. Maruoka; H. Yamamoto

  Tetrahedron, 1988, Peer-reviewed

  
• UNUSUAL CONJUGATE ADDITION OF ORGANOLITHIUM REAGENT TO ALPHA,BETA-UNSATURATED KETONE

  K MARUOKA; K NONOSHITA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1987, Peer-reviewed

  
• ORGANOBORANE-CATALYZED HYDROALUMINATION OF OLEFINS

  K MARUOKA; H SANO; K SHINODA; S NAKAI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1986, Peer-reviewed

  
• EPOXY SILYL ETHER REARRANGEMENTS - A NEW, STEREOSELECTIVE APPROACH TO THE SYNTHESIS OF BETA-HYDROXY CARBONYL-COMPOUNDS

  K MARUOKA; M HASEGAWA; H YAMAMOTO; K SUZUKI; M SHIMAZAKI; G TSUCHIHASHI

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1986, Peer-reviewed

  
• ASYMMETRIC DIELS-ALDER REACTION DIRECTED TOWARD CHIRAL ANTHRACYCLINE INTERMEDIATES

  K MARUOKA; M SAKURAI; J FUJIWARA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1986, Peer-reviewed

  
• ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

  S SAKANE; K MARUOKA; H YAMAMOTO

  TETRAHEDRON, 1986, Peer-reviewed

  
• CHIRAL LEAVING GROUP - ASYMMETRIC-SYNTHESIS OF LIMONENE AND BISABOLENE

  S SAKANE; J FUJIWARA; K MARUOKA; H YAMAMOTO

  TETRAHEDRON, 1986, Peer-reviewed

  
• SELECTIVE ORGANIC-SYNTHESIS USING ORGANO-ALUMINUM REAGENTS

  K MARUOKA; H YAMAMOTO

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1985, Peer-reviewed

  
• Selective Reactions using Organoaluminum Reagents

  丸岡 啓二

  Angewandt Chemie, Int. Ed. Engl.,24/8, 1985, Peer-reviewed

  
• ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

  S SAKANE; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1985, Peer-reviewed

  
• NUCLEOPHILIC CLEAVAGE OF ACETALS USING ORGANOMETALLIC REAGENTS

  A MORI; J FUJIWARA; K MARUOKA; H YAMAMOTO

  JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1985, Peer-reviewed

  
• A NEW, STEREOCONTROLLED SYNTHESIS OF EQUATORIAL ALCOHOLS BY THE AMBIPHILIC REDUCTION OF CYCLOHEXANONES

  K MARUOKA; M SAKURAI; H YAMAMOTO

  TETRAHEDRON LETTERS, 1985, Peer-reviewed

  
• Trialkylaluminum-alkylidene iodide. A powerful cyclopropanation agent with unique selectivity [1]

  K. Maruoka; Y. Fukutani; H. Yamamoto

  Journal of Organic Chemistry, 1985, Peer-reviewed

  
• METHYLALUMINUM BIS(2,6-DI-TERT-BUTYL-4-ALKYLPHENOXIDE) - A NEW REAGENT FOR OBTAINING UNUSUAL EQUATORIAL AND ANTI-CRAM SELECTIVITY IN CARBONYL ALKYLATION

  K MARUOKA; T ITOH; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, Peer-reviewed

  
• STEREOSELECTIVE CONJUGATE ADDITION OF ORGANO-ALUMINUM REAGENTS TO CHIRAL ALPHA,BETA-UNSATURATED KETALS

  Y FUKUTANI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1984, Peer-reviewed

  
• A NEW SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES BY MEANS OF ORGANO-ALUMINUM REAGENTS

  J FUJIWARA; H SANO; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1984, Peer-reviewed

  
• UNPRECEDENTED REGIOCHEMICAL AND STEREOCHEMICAL CONTROL IN THE ADDITION OF ORGANO-ALUMINUM REAGENTS TO CHIRAL ALPHA,BETA-UNSATURATED ACETALS

  J FUJIWARA; Y FUKUTANI; M HASEGAWA; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, Peer-reviewed

  
• NUCLEOPHILIC CLEAVAGES OF ACETALS USING ORGANOTITANIUM REAGENTS - A NEW SYNTHESIS OF CHIRAL ALCOHOLS

  A MORI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1984, Peer-reviewed

  
• SELECTIVE REACTIONS USING ORGANO-ALUMINUM REAGENTS

  H YAMAMOTO; K MARUOKA

  PURE AND APPLIED CHEMISTRY, 1983, Peer-reviewed

  
• ASYMMETRIC REDUCTION OF KETONE REDUCTIVE CLEAVAGE OF CHIRAL ACETALS USING ORGANO-ALUMINUM REAGENTS

  A MORI; J FUJIWARA; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1983, Peer-reviewed

  
• NUCLEOPHILIC AROMATIC-SUBSTITUTION BY ORGANO-ALUMINUM REAGENTS - APPLICATION TO THE SYNTHESIS OF INDOLES

  J FUJIWARA; Y FUKUTANI; H SANO; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed

  
• CARBON CARBON BOND FORMATION BY SELECTIVE COUPLING OF ENOL SILYL ETHERS WITH OXIME SULFONATES

  Y MATSUMURA; J FUJIWARA; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed

  
• CONCENTRATION PROFILE OF CU-2+ ION NEAR A PLANE VERTICAL CATHODE IN ELECTROLYTES CONTAINING CUSO4 AND AN EXCESS OF H2SO4 AS A SUPPORTING ELECTROLYTE

  Y FUKUNAKA; K DENPO; M IWATA; K MARUOKA; Y KONDO

  JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 1983, Peer-reviewed

  
• A NEW SYNTHESIS OF IMIDOYL IODIDES VIA BECKMANN REARRANGEMENT OF OXIME SULFONATES

  Y ISHIDA; S SASATANI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1983, Peer-reviewed

  
• OLEFINIC CYCLIZATION PROMOTED BY BECKMANN REARRANGEMENT OF OXIME SULFONATE SYNTHESIS OF DL-MUSCONE

  S SAKANE; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1983, Peer-reviewed

  
• OLEFINIC CYCLIZATIONS PROMOTED BY BECKMANN REARRANGEMENT OF OXIME SULFONATE

  S SAKANE; Y MATSUMURA; Y YAMAMURA; Y ISHIDA; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed

  
• DIISOBUTYLALUMINUM HYDRIDE - A NOVEL REAGENT FOR THE REDUCTION OF OXIMES

  S SASATANI; T MIYAZAKI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1983, Peer-reviewed

  
• CHIRAL LEAVING GROUP - BIOGENETIC-TYPE ASYMMETRIC-SYNTHESIS OF LIMONENE AND BISABOLENES

  S SAKANE; J FUJIWARA; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed

  
• ORGANOALUMINUM-PROMOTED BECKMANN REARRANGEMENT OF OXIME SULFONATES

  K MARUOKA; T MIYAZAKI; M ANDO; Y MATSUMURA; S SAKANE; K HATTORI; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed

  
• STEREOSELECTIVE SYNTHESES OF SOLENOPSIN-A AND SOLENOPSIN-B

  Y MATSUMURA; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1982, Peer-reviewed

  
• BIOMIMETIC ENTRY TO ACYCLIC TERPENE SYNTHESIS A NOVEL REARRANGEMENT OF ALLYL ETHER CATALYZED BY ORGANO-ALUMINUM REAGENTS

  Y YAMAMURA; K UMEYAMA; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1982, Peer-reviewed

  
• BECKMANN REARRANGEMENT OF OXIME SULFONATES BY GRIGNARD-REAGENTS

  K HATTORI; K MARUOKA; H YAMAMOTO

  TETRAHEDRON LETTERS, 1982, Peer-reviewed

  
• TOTAL SYNTHESIS OF (+/-)-CELACINNINE, (+/-)-CELALLOCINNINE, (+/-)-CELAFURINE, AND (+/-)-CELABENZINE

  H YAMAMOTO; K MARUOKA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, Peer-reviewed

  
• SUCCESSIVE BECKMANN REARRANGEMENT-ALKYLATION SEQUENCE BY ORGANO-ALUMINUM REAGENTS - A SIMPLE ROUTE TO DL-PUMILIOTOXIN-C

  K HATTORI; Y MATSUMURA; T MIYAZAKI; K MARUOKA; H YAMAMOTO

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, Peer-reviewed

  
• REGIOSELECTIVE CARBONYL AMINATION USING DIISOBUTYLALUMINUM HYDRIDE

  H YAMAMOTO; K MARUOKA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, Peer-reviewed

  
• NOVEL N-ALKYLATION OF AMINES WITH ORGANOCOPPER REAGENTS

  H YAMAMOTO; K MARUOKA

  JOURNAL OF ORGANIC CHEMISTRY, 1980, Peer-reviewed

  
• Intramolecular dibromo ketone-iron carbonyl reaction in terpene synthesis [5]

  R. Noyori; M. Nishizawa; F. Shimizu; Y. Hayakawa; K. Maruoka; S. Hashimoto; H. Yamamoto; H. Nozaki

  Journal of the American Chemical Society, 1979, Peer-reviewed

  
• A new and highly effective aldol synthesis [2]

  K. Maruoka

  Journal of the American Chemical Society, 1977, Peer-reviewed

  

Misc.

• Stereoselective terminal functionalization of small peptides for catalytic asymmetric synthesis of unnatural peptides

  K Maruoka; E Tayama; T Ooi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2004, Peer-reviewed

  
• Catalytic asymmetric synthesis of alpha-amino acid derivatives and peptides using chiral phase-transfer catalysts

  K Maruoka

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, Sep. 2003, Peer-reviewed

  

Presentations

• Design of High-Performance Organocatalysts for Green Sustainable Chemistry: A Good Harmony with Water

  The 2nd Korea Forum on Organic Chemistry-KSOS, 23 Nov. 2012

  
• Design of High-Performance Organocatalysts for the Efficient Synthesis of Both Enantiomeric Products

  COST ORCA Meeting, 01 Nov. 2012

  
• The Power of Asymmetric Phase Transfer Catalysis

  International Conference “Catalysis in Organic Synthesis”, 15 Sep. 2012

  
• Design of Single and Supramolecularly Assembled Organocatalysts for Green Sustainable Chemistry

  The Chinese Chemical Society Annual Meeting, 04 Dec. 2011

  
• New Frontier on Organocatalytic Aldol Chemistry: Development of anti- and syn-Selective Asymmetric Cross-Aldol Reaction of Two Different Aldehydes

  Tenth International Conference on Organic Reactions (10th ISOR), 21 Nov. 2011

  
• Design of High-Performance Phase-Transfer Catalysts as Promising Organocatalysts

  Second International Collaborative and Cooperative Chemistry Symposium (2nd ICCCS), 31 Oct. 2011

  
• Development of New Synthetic Methodologies of α-Diazo Carbonyl Compounds Promoted by Metal and Organocatalysts

  The 5th International Symposium: The Chemistry of Aliphatic Diazo Compounds: Advances and Outlook, 07 Jun. 2011

  
• Design of High-Performance Organocatalysts for the Development of Environmentally-Benign Reactions for Green Sustainable Chemistry

  12th Spring Meeting of Synthetic Chemistry, 07 Jun. 2011

  
• Design of High-Performance Organocatalysts for Green Sustainable Chemistry

  CATAFLU.OR Symposium, 24 Mar. 2011

  
• Organocatalytic Way to the Asymmetric Synthesis of Small Peptides

  PACIFICHEM2010 - Frontiers in Peptide Chemistry: Synthesis and Applications Symposium, 18 Dec. 2010

  
• New Discovery in Asymmetric Phase-Transfer Catalysis

  PACIFICHEM2010 - New Dimension of Green Sustainable Chemistry: Novel Reactions and Catalysts Symposium, 15 Dec. 2010

  
• Design of High-Performance Bifunctional Organocatalysts

  International Symposium on Organocatalysis (ISOμ 2010), 14 Jul. 2010

  
• Design of High-Performance Bifunctional Organocatalysts for Practical Asymmetric Synthesis

  First International Conference on Advancing the Chemical Science (1st ICACS), 07 Jul. 2010

  
• Surprising Discovery on Base-Free Phase-Transfer Reactions

  Eleventh International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11), 09 Nov. 2009

  
• Design of High-Performance Organocatalysts for Practical Asymmetric Synthesis

  Chemistry Conference on "Frontiers in Synthesis, Catalysis and Biochemistry", 13 Sep. 2009

  
• Organocatalytic Way to the Asymmetric Synthesis of Useful Amino Acids and Alkaloids

  20th International Symposium on Chirality, 06 Jul. 2008

  
• (131) Designer Chiral Organocatalysts for Catalytic Asymmetric Synthesis

  International Workshop on Green Chemistry, 28 Apr. 2008

  
• Design of Binaphthyl-Modified Chiral Organocatalysts for Asymmetric Synthesis

  9 th Netherlands Catalysis and Chemistry Conference, 03 Mar. 2008

  
• Binaphthyl-Modified Chiral Organocatalysts for Practical Asymmetric Synthesis

  2 nd ERA-Chemistry Flash Conference on “Catalysis without Metal”, 28 Oct. 2007

  
• Designer Chiral Organocatalysts for Practical Asymmetric Synthesis

  Gordon Research Conference on Organic Reactions and Processes, 15 Jul. 2007

  
• (104) Design of Chiral Phase Transfer Catalysts for Practical Asymmetric Synthesis

  8th International Symposium on Carbanion Chemistry (ISCC-8), 06 Jun. 2007

  
• Practical Asymmetric Synthesis with Designer Chiral Organocatalysts

  9th International Symposium for Chinese Organic Chemists (ISCOC-9), 17 Dec. 2006

  
• Designer Chiral Phase Transfer Catalysts for Practical Asymmetric Synthesis

  Organocatalysis Synposium in the 232nd ACS National Meeting, 10 Sep. 2006

  
• Catalytic Asymmetric Synthesis with Chiral Designer Phase Transfer Catalysts

  16th IUPAC’s International Conference on Organic Synthesis (ICOS-16), 11 Jun. 2006

  
• Catalytic Asymmetric Synthesis with Designer Chiral Organocatalysts

  7th Tetrahedron Symposium, 25 May 2006

  
• Design of Extremely Active Chiral Phase Transfer Catalyst for Practical Asymmetric Synthesis

  PACIFICHEM2005-Organocatalyzed Asymmetric Synthesis Symposium, 17 Dec. 2005

  
• Design of Powerful Chiral Phase Transfer Catalysts for Asymmetric Carbon-Carbon Bond Formation

  10th International Chemical Conference in Taipei (ICCT 10), 28 Oct. 2005

  
• Design of C2-Symmetric Chiral Phase-Transfer Catalysts as Chiral Organocatalysts for Practical Asymmetric Synthesis

  40th Euchem Conference on Stereochemistry, 16 Apr. 2005

  

Books and Other Publications

• Asymmetric α-Functionalization of Carbonyl Compounds and Alkylation of Enolates

  丸岡 啓二

  Georg Thieme Verlag KG: Stuttgart, 2012, Not refereed

  
• Asymmetric Organocatalysis: Vol. 6

  丸岡 啓二

  Georg Thieme Verlag KG: Stuttgart, 2012, Not refereed

  
• Asymmetric Phase-Transfer Catalysis

  丸岡 啓二

  Wiley-VCH: Weinheim,, 2012, Not refereed

  
• Comprehensive Chirality: Vol. 5

  丸岡 啓二

  Elsevier, 2012, Not refereed

  
• Asymmetric Catalysis on Industrial Scale, Second Edition

  丸岡 啓二

  Wiley-VCH, Jul. 2010, Not refereed

  
• 使える！有機合成反応241実践ガイド

  丸岡 啓二

  化学同人, 01 Apr. 2010, Not refereed

  Find Kyoto University's collection of books :

  
• Catalytic Asymmetric Synthesis, Third Edition

  丸岡 啓二

  化学同人, Mar. 2010, Not refereed

  
• Handbook of Cyclization Reactions

  丸岡 啓二

  Wiley-VCH, Dec. 2009, Not refereed

  
• 進化を続ける有機触媒, 丸岡啓二編

  丸岡 啓二

  化学同人, 30 Jul. 2009, Not refereed

  
• Asymmetric Synthesis and Application of α-Amino Acids: ACS Symposium Series

  丸岡 啓二

  American Chemical Society,Vol.1009, Jun. 2009, Not refereed

  
• Handbook of Asymmetric Heterogeneous Catalysis

  丸岡 啓二

  Wiley-VCH, Nov. 2008, Not refereed

  
• Asymmetric Phase Transfer Catalysis

  丸岡 啓二

  Wiley-VCH, Apr. 2008, Not refereed

  
• Catalytic Asymmetric Synthesis

  丸岡 啓二

  VCH Publishers, Inc.,413-40, 1993, Not refereed

  
• Asymmetric Reactions with Chiral Lewis Acid Catalysts

  丸岡 啓二

  VCH Publishers,, 1993, Not refereed

  

Industrial Property Rights

• (18) 光学活性α-置換マンデル酸化合物の製造方法

  
• (17) アルジミンまたはその誘導体を用いる一置換アルキル化化合物の製造方法

  
• 軸不斉を有する光学活性アミノ酸誘導体及び該アミノ酸誘導体を不斉触媒として用いる光学活性化合物の製造方法

  
• 軸不斉を有する光学活性な４級アンモニウム塩を用いたα-アミノ酸誘導体の製造方法

  
• 光学活性４級アンモニウム塩化合物およびそれが触媒する不斉エポキシ化反応

  
• 光学活性3,5-ジヒドロ-4H-ジナフト[2,1-c:1ﾕ,2ﾕ-e]アゼピンおよびそのシュウ酸塩の製造方法

  
• キラル相間移動触媒およびそれを用いた不斉ペプチドの製造方法

  
• ビナフチル基およびビフェニル基を含むＮ-スピロ不斉相間移動触媒

  
• 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα-アミノ酸誘導体の不斉合成への応用

  
• 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα-アミノ酸誘導体の不斉合成への応用

  

Awards

• 1986

  日本化学会, 日本化学会進歩賞
• 2001

  井上科学振興財団, 井上学術賞
• 2002

  新技術開発財団, 市村学術賞
• 2003

  有機合成化学協会, 有機合成化学協会賞
• 2004

  万有生命科学振興国際交流財団, 名古屋シルバーメダル
• 2006

  グリーンサステイナブルケミストリーネットワーク・文部科学省, グリーン・サステイナブル・ケミストリー賞・文部科学大臣賞
• 2007

  Molecular Chirality Research Organization, モレキュラー・キラリティー賞
• 2007

  日本化学会, 日本化学会賞
• 2007

  ノバルティス製薬, ノバルティス・レクチャーシップ賞
• 2010

  中日新聞, 中日文化賞
• 2011

  American Chemical Society, Arthur C. Cope Scholar Award
• 2011

  Humboldt Foundation, Humboldt Senior Research Award
• Nov. 2011

  日本政府内閣府, 紫綬褒章
• 2012

  東レ科学振興会, 東レ科学技術賞
• 2012

  京都新聞社, 京都新聞大賞　文化学術賞

External funds: Kakenhi

• Development of new catalysts and precise synthetic reactions directed for peptide drug synthesis

  Grant-in-Aid for Scientific Research (S)

  Broad Section E

  Kyoto University

  丸岡 啓二

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  ペプチド医薬;金属触媒;有機触媒;ラジカル触媒;精密合成反応;ペプチド合成;かさ高いアミノ酸;超原子価ヨウ素;アミノ化合物;フッ化アシル;ペプチド開裂反応;ベンジルラジカル;カチオン性DABCO型触媒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05026/
• Functional Creation of Designer N-Oxy Radicals for the Development of New Organoradical Catalysts

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 33:Organic chemistry and related fields

  Kyoto University

  Keiji Maruoka

  From 30 Jul. 2020, To 31 Mar. 2023, Project Closed

  ラジカル反応;有機ラジカル触媒;N-オキシラジカル;N-ヒドロキシベンズイミダゾール;ベンジル位;アルデヒド;アシルラジカル;フッ化アシル;ラジカル触媒;N-ヒドロキシフタルイミド;プリビリッジド構造;炭素ラジカル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21193/
• Development of Highly Selective Domino Reactions using High-Performance Hybrid Catalyst System

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  Keiji Maruoka

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  ハイブリッド触媒;ドミノ反応;精密有機合成;有機分子触媒;金属錯体触媒;ペプチド;臭化銅;セレクトフルオル;ラジカル反応;フッ化アシル;超原子価ヨウ素;アルキルシリルペルオキシド;環状アセタール;β-ヒドロキシアルデヒド;セロトニン拮抗薬;酸フッ化物;アミン触媒;不斉ベンゾイロキシ化反応;ラジカル;セミピナコール転位;アルキルシリルパーオキシド;Ｎ－ヒドロキシベンゾイミダゾール

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06450/
• Design of Next-Generation Organocatalysts for the Application to Practical, Fine Organic Synthesis

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Keiji MARUOKA

  From 30 May 2014, To 31 Mar. 2019, Project Closed

  高性能有機触媒;精密有機合成;塩基触媒;酸触媒;酸塩基複合触媒;ラジカル触媒;環境調和型;不斉変換反応;次世代型有機触媒;有機塩基触媒;脱芳香族化反応;不斉共役付加反応;有機酸塩基触媒;有機ラジカル触媒;NHBI触媒;アシル化反応;有機触媒;脱金属触媒;次世代型触媒;ベンゾイロキシ化反応;共役付加反応;有機ラジカル;ジフルオロメチル化剤;キラル相間移動触媒;二官能性触媒;ラクトン化反応;有機分子触媒;精密有機合成反応;不斉アルドール反応;オキシインドール;アシルラジカル;有機酸職場

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26220803/
• 化学合成を指向する新方法論としてのレドックス有機触媒反応

  Grant-in-Aid for JSPS Fellows

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  軸性キラルアニリド;不斉合成;キラル相間移動触媒;エナンチオ選択性;ラジカル環化反応;アルデヒド;共役付加反応;二官能性有機アミン触媒;有機合成;有機触媒;レドックス触媒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12F02034/
• 多機能性分子触媒の創製と合成的応用

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2009, To 31 Mar. 2010, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21245010/
• Design of High-Performance Organocatalysts for the Application to Fine Organic Synthesis

  Grant-in-Aid for Specially Promoted Research

  Science and Engineering

  Kyoto University

  Keiji MARUOKA

  From 01 Apr. 2009, To 31 Mar. 2015, Project Closed

  高性能有機触媒;精密有機合成;塩基触媒;酸触媒;酸塩基複合触媒;ラジカル触媒;環境調和型;不斉変換反応;キラル相間移動触媒;不斉アルドール反応;キノンイミンケタール;不斉Diels-Alder反応;有機ラジカル;二官能性触媒;アミナール;1,3-双極子付加環化反応;触媒的不斉合成;アルキル化反応;不斉共役付加反応;マンニッヒ反応;アゲラスタチンＡ;Ugi反応;有機触媒;有機酸触媒;有機ラジカル触媒;共役付加反応;エナンチオ選択的;アゾメチンイミン;交差型アルドール反応;不斉アルキル化;イミノアザエナミン反応;遠隔不斉制御;有機二官能性触媒;不斉フッ素化反応;不斉マンニッヒ反応;交差アルドール反応;キラルジカルボン酸;双極子付加環化反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21000006/
• Fine Design of Bidentate Lewis Acid Catalysts and their Synthetic Application

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Keiji MARUOKA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  触媒的不斉合成;二点配位型;ルイス酸;ブレンステッド酸;有機触媒;二点配位型触媒;不斉合成;精密有機合成化学;チタン触媒;イミノアザエナミン反応;アジリジン化反応;デザイン;1,3-双極子環状付加;シクロプロパン化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19350020/
• Development of Advanced Molecular Transformations of Functional Carbon Molecules using Fine Acid-Base Catalysts

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  Keiji MARUOKA

  From 01 Apr. 2005, To 31 Mar. 2009, Project Closed

  炭素資源;有機酸塩基触媒;高度分子変換;プロセス有機合成化学;キラル相間移動反応;光学活性アミノ酸;二官能基性有機触媒;キラルジカルボン酸触媒;キラル相間移動触媒;キラル二官能性アミン触媒;不斉アミノ化反応;不斉マンニッヒ反応;アルドール反応;キラルジカルボン酸;イミノアザエナミン反応;炭素炭素結合形成反応;アミノ酸;不斉共役付加反応;不斉アルドール反応;不斉分子変換反応;二官能基性触媒;不斉ヒドロキシアミノ化;スピロ型アンモニウム塩;クラウンエーテル;人工アミノ酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17065010/
• 炭素資源の高度分子変換

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  炭素資源;高度分子変換;シンポジウム;成果報告書;要旨集;ポスター;計画班員;公募班員;新機能性材料;医農薬;プロセス有機合成化学;公開シンポジウム;国際会議;ニュースレター;高度分子変換反応;創設シンポジウム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17065009/
• 二点配位型キラルチタン錯体の創製と新規不斉合成反応の案出

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  二点配位型キラルチタン触媒;二点配位型ルイス酸;精密有機合成;不斉アリル化;アルデヒド;アルドール体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15036235/
• Design of Fine Acid Base Catalysts and their Utility in Selective Organic Synthesis

  Grant-in-Aid for Scientific Research (S)

  KYOTO UNIVERSITY

  Keiji MARUOKA

  From 01 Apr. 2001, To 31 Mar. 2006, Project Closed

  精密有機合成化学;精密酸塩基触媒;触媒的不斉合成;二点配位型ビス-チタン;二重活性化;キラル相間移動触媒;光学活性人工アミノ酸;機能性有機金属分子;精密合成反応プロセス;精密ルイス酸触媒;二点配位型ルイス酸;不斉双極子環状付加;マンザシジンA;不斉ストレッカー反応;不斉マンニッヒ反応;精密ルイス酸;カルボニル;グリシンエステル;不斉アルキル化反応;不斉アルドール反応;不斉共役付加反応;不斉アリル化;ティシュチェンコ反応;不斉ニトロアルドール反応;シリル化合物;Neber転位;精密合成;不斉合成;ルイス酸;二点配位型;キラル触媒;相間移動触媒;L-ドーバ, acid;base catalysts;bidentate Ti(IV) complex;enantioselective allylation;1, 3-dipolar cycloaddition;phase transfer catalysis;binaphthol;amino acid;Strecker reaction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13853003/
• 環境調和を指向する有用アミノ酸類の実用的不斉合成プロセスの開発

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  キラル相間移動触媒;触媒的不斉合成;有用アミノ酸;シンコナアルカロイド;ビナフトール;グリシン;不斉アルキル化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13554021/
• 半球型有機金属分子のデザインと精密有機合成化学への応用

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  トリアルキルシリル;カルボン酸;半球型分子;有機ケイ素;アルキルリチウム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13440215/
• 光学活性メタラ環状化合物の創製と不斉合成への応用

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Science and Engineering

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  メタラ環状化合物;二点配位型ルイス酸;亜鉛化合物;プロリン;不斉アルキル化;アミノアルコール;不斉合成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13029055/
• フッ素原子による機能の創出

  Grant-in-Aid for Scientific Research (C)

  Tokyo University of Pharmacy and Life Science

  田口 武夫

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  フッ素;フッ素化;トルフルオロメチル;ジフルオロメチレン;フルオロアルキル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12895025/
• 先例のないキレート型高配位典型金属錯体の創製と精密有機合成への活用

  Grant-in-Aid for Exploratory Research

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  典型金属化合物;有機アルミニウム;キレート;アルコキシケトン;ルイス酸;ボラン;トリブチルスズヒドリド;高配位典型金属;精密有機合成;アルミニウム;ホウ素;ジアステレオ選択性;アピカル型

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12874072/
• Design of Metal Artificial Enzymes and the Application to Fine Organic Synthesis

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY;Hokkaido University

  Keiji MARUOKA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  有機合成化学;ハロゲン化アルキル;炭素ラジカル;隣接基関与;炭素アニオン種;アニオン種;ヘテロ原子;セレン;テルル;金属ハロゲン交換;炭素炭素結合形成, organic synthesis;alkyl halides;carbon-centered radicals;anchimeric effect;carbanion species

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11440184/
• Dynamic Stereochemical Control by Using Lewis Acid Base Active Species

  Grant-in-Aid for Scientific Research on Priority Areas (B)

  KYOTO UNIVERSITY;Hokkaido University

  Keiji MARUOKA

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  ルイス酸塩基活性種;5配位ホウ素錯体;二点配位型金属触媒;動的立体化学制御;アミノ酸;光学活性希土類錯体;モンモリロナイト触媒;カルボアニオン反応;不斉環化反応;不斉エポキシ化;速度論的光学分割;ルイス酸活性種;5配位ホウ素鎖体;立体化学制御;機能性ルイス酸触媒;光学活性希土類鎖体;固体触媒;5配位典型金属活性種;二点配位型有機金属分子;機能性ルイス酸;精密環化重合;希土類ルイス酸塩基触媒;カルポアニオン反応, Lewis acid;base active species;pentacoordinate boron complex;bidentate metal catalyst;dynamic stereochemical control;amino acid;chiral rare-earth metal complex;montmorillonite catalyst;carbanion reaction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10208201/
• Dynamic Stereocontrol

  Grant-in-Aid for Scientific Research on Priority Areas (B)

  Kyushu University

  Tsutomu KATSUKI

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  立体化学;有機化学;合成化学;触媒・化学プロセス;分子認識;キラル分離;動的立体化学制御;光活性化;二点配位;不斉アリル化;エンド環化;ビニルシラン;光学活性カラム;サレン金属錯体;立体配座;電子移動型反応;カルボニルイリド;不斉識別能;不斉金属錯体触媒;立体配座制御;ルイス酸活性種;不安定活性種;電極反応制御;非安定化カルボニルイリド;不斉識別機構, stereocontrol;chiral recognition;asymmetric catalysis;Asymmetric allylation;endo-Cyclization;Vinylsilane;organic synthesis;chirality

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10208104/
• Design of Intermolecular Interactions and Dynamic Stereochemical Control by Using Lewis Acid Base Active Species

  Grant-in-Aid for Scientific Research on Priority Areas (B)

  KYOTO UNIVERSITY;Hokkaido University

  Keiji MARUOKA

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  ルイス酸活性種;動的立体化学制御;5配位ホウ素;二点配位型チタン触媒;不斉触媒;触媒的不斉反応;多機能触媒;複合酸塩基金属錯体;分子間相互作用;三フッ化ホウ素;二点配位型触媒;サレン-ルテニウム錯体;不斉シクロプロパン化;光学活性ビスホスフィン;5配位典型金属;二点配位型有機金属分子, Lewis acid;base active species;dynamic stereochemical control;pentacoordinate boron;bidentate titanium catalyst;asymmetric catalyst;catalytic asymmetric synthesis;multifunctional catalyst;combined acid;base metal catalyst

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10208101/
• ダブルターゲティング能を有する人工酵素のデザインと機能開発

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ルイス酸型人工酵素;ATPH;カプセル分子;二官能性基質;集積型錯体;環状付加反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10145201/
• 次世代ルイス酸・反応剤の精密設計

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  二点配位型ルイス酸;ケトン還元;向山アルドール反応;N,N-ジメチルホルムアミド;二重活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09231204/
• 特殊反応場を提供するルイス酸の触媒設計

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  共役アルキル化反応;機能性ルイス酸;ATPH;アンフィフィリック;p-F-ATPH;α,β,γ,δ-不飽和カルボニル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09218201/
• Practical Synthesis of Phisiologically Active Substances Using Functionalized Lewis Acids

  Grant-in-Aid for Scientific Research (A)

  HOKKAIDO UNIVERSITY

  Keiji MARUOKA

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  ATPH;ラジカル反応;二点配位;アルミニウム;チタン;官能基選択性;機能性ルイス酸;二点配位型アルミニウム;二点配位型チタン;アリルトリブチルスズ;ケトン還元;テンプレート;α, β-不飽和アルデヒド, ATPH;radical reaction;conjugate alkylation;aluminum;titanium;chemoselectivity

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08555225/
• Design of Metal Artificial Enzymes and the Application to Fine Organic Synthesis

  Grant-in-Aid for Scientific Research (A)

  HOKKAIDO UNIVERSITY

  Keiji MARUOKA

  From 01 Apr. 1996, To 31 Mar. 1999, Project Closed

  二点配位型ルイス酸;有機アルミニウム反応剤;二点配位型チタン触媒;向山アルドール反応;光学活性ビナフトール;光学活性チタン触媒;不斉アリル化反応;エナンチオ選択性;実用的不斉合成;カルボニル化合物;チタン;ケトン還元;アリル化;エポキシド;有機アルミニウム;N, N-ジメチルホルムアミド, bidentate Lewis acid;organoaluminum reagent;bidentate titanium catalyst;Mukaiyama aldol reaction;chiral binaphthol;chiral titaniumu catalyst;asymmetric allylation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08404049/
• 次世代ルイス酸反応剤の精密設計

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  アリルトリアルキルスズ;中性有機金属化合物;キレート形成;ビス(アリル)スズ化合物;ビス(プレニル)スズ化合物;官能基選択的アリル化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08245205/
• 実践的合成プロセスの開発

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  伊藤 嘉彦

  From 01 Apr. 1996, To 31 Mar. 1999, Project Closed

  シリルホウ素化反応;不斉エポキシ化反応;分子内ディールス・アルダー反応;N-トシル-4-ビニリデン-2-オキサゾリジノン;タキソールの合成;二点配位型チタン系ルイス酸;光学活性アリルシランの合成;パラジウム(0)イソニトリル錯体;ο-アリリックヒドロキシアミンの〔2,3〕転位;ベンジル位の不斉ヒドロキシル化;メソ環状エーテルの非対称化による不斉合成;タキソ-ル不斉全合成;アリルスズとアルデヒドの分子内反応;海洋産ポリ環状エーテルの合成;キラル金属錯体触媒;触媒的不斉反応;タキソ-ル骨格の構築;アミンのα-位酸化触媒;アリル金属試薬;アリル化剤;光学活性アリルシラン;光学活性アレニルシラン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08245104/
• 特殊反応場を提供するルイス酸の触媒設計

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  共役アルキル化反応;機能性ルイス酸;ATPH;α,β-不飽和カルボニル;アンフィフィリック;p-F-ATPH

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08232201/
• 2点配位型ルイス酸触媒の開発

  Grant-in-Aid for General Scientific Research (C)

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  二点配位型ルイス酸;有機アルミニウム;エクアトリアル選択性;共役付加反応;カルボニル基

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07805081/
• 機能性有機アルミニウム反応剤の創製とその高選択的合成反応への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  機能性有機アルミニウム;求核的芳香族置換反応;芳香族アルデヒド;芳香核ケトン;ATPH

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07216230/
• 新しい光学活性アルミニウム反応剤を用いる不斉クライゼン転位反応の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Hokkaido University

  丸岡 啓二

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  光学活性アルミニウム反応剤;不斉クライゼン転位;アリル ビニル エーテル;光学活性配位子;光学活性ビナフトール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07214215/
• Development of a new molecular recognition chemistry using Lewis acidic receptors

  Grant-in-Aid for Scientific Research (A)

  Nagoya University

  Hisashi YAMAMOTO

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  ルイス酸型レセプター;アルミニウム反応剤;デザイン型ルイス酸;ルイス塩基;選択的有機合成;分子認識化学;ルイス酸塩基複合体;ルイス塩基複合体;有機アルミニウム;複合体形成クロマトグラフィー, Lewis acidic receptor;Aluminum reagent;Designer Lewis acid;Lewis base;Selective organic synthesis;Molecular recognition chemistry;Lewis acid-base complex

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06403024/
• 有機アルミニウム化合物を用いる新規ルイス酸塩基複合体形成クロマトグラフィーの開発

  Grant-in-Aid for General Scientific Research (C)

  Nagoya University

  丸岡 啓二

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  有機アルミニウム;ルイス酸型レセプター;クロマトグラフィー;エポキシド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04650769/
• アリル型有機金属化合物の高選択的反応の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  山本 尚

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  アリル型金属化合物;高配位化合物;立体選択的発生法;アリルバリウム反応剤;α-アリル化反応;異性化温度;カルボキシル化反応;ホモアリルアルコール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04217211/
• Development of New Molecular Recognition Chemistry using Organoaluminums

  Grant-in-Aid for General Scientific Research (B)

  Nagoya University

  Hisashi YAMAMOTO

  From 01 Apr. 1991, To 31 Mar. 1993, Project Closed

  ルイス酸型レセプター;有機アルミニウム;分子認識化学;複合体形成クロマトグラフィー;ディールズ・アルダー反応;光学活性アルミニウム反応剤;ビナフトール;不斉クライゼン転位;不斉ディールズ・アルダー反応;ルイス酸型レセプタ-;複合体形成クロマトグラフィ-;ディ-ルズ・アルダ-反応, Lewis Acidic Receptor;Organoaluminums;Molecular Recognition;Complexation Chromatography;Diels-Alder Reaction;Chiral Organoaluminums;Binaphthols;Asymmetric Claisen Rearrangement

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03453100/
• アリル型有機金属化合物の高選択的反応の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  山本 尚

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  アリル型金属化合物;高配位化合物;位置制御;非対称型アリルカルボアニオン;αー選択的アリル化;アシルシラン類;立体制御;異性化温度

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03233211/
• キラルルイス酸触媒の開発による反応の高次制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  山本 尚

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  光学活性アルミニウム反応剤;光学活性ホウ素反応剤;ヘテロ・ディ-ルズ・アルダ-反応;エン反応;クライゼン転位;アルド-ル反応;エナンチオ面区別反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03215215/
• Development of New Organic Reactions and Synthesis of Physiologically Active Substance

  Grant-in-Aid for Specially Promoted Research

  Nagoya University

  Ryoji NOYORI

  From 01 Apr. 1987, To 31 Mar. 1991, Project Closed

  新有機化学反応;有機,鉛化合物;高選択的1,4ー付加反応;パラジウム(0)錯体触媒;新脱保護法;不斉水素化;BINAP;DAIB;有機亜鉛;アルキル化;不斉クライゼン転位;アリル系保護基;超純度DNA合成;超原子価スズ化合物;分子内エン反応;アミノアルコール;有機亜鉛化合物;アシロキシボラン;不斉DielsーAlder反応;BINAP錯体;プロスタグランジン合成;DNA固相合成;不斉アルキル化;有機アルミニウム;不斉増幅;不斉触媒;O価バラジウム;2-5A;アントラサイクリン;アリルオキシカルボニル;パラジウム;イソカルバサイクリン;ルテニウム錯体;1-βメチルチエナマイシン;ナブロキャン;シトロネロール;ビタミン;プロスタグランジン, BINAL-H;TMSOTf;BINAP;BINAP-Rh;BINAP-Ru;MAD;CAB;Pd(0)Catalyzed deprotection

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62065005/
• Development of Industrial Synthetic Process Toward Prostaglandins

  Grant-in-Aid for Developmental Scientific Research

  Nagoya University

  Hisashi YAMAMOTO

  From 01 Apr. 1985, To 31 Mar. 1987, Project Closed

  プロスタグランジン;ジアニオン;不斉DielsーAlder;アレニルアニオン;不斉シクロプロパン化;不斉Diels-Alder;不斉合成, Prostaglandin;Dianion;Asymmetric Diels-Alder;Allenyl Anion

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60850154/
• Design of New Green Catalysts and their Application to the Development of Precise Synthetic Reactions Based on Electron Transfer Control

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  Kyoto University

  丸岡 啓二

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  グリーン触媒;HAT触媒;ラジカル触媒;光照射;選択的有機合成反応;精密合成反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H04910/