Basic Information

Faculty

• 医学部

Professional Memberships

• 日本免疫不全・自己炎症学会
• 日本皮膚アレルギー接触皮膚炎学会
• 日本研究皮膚科学会
• 日本皮膚科学会
• 日本アレルギー学会

Academic Degree

• 博士（医学）(群馬大学)

Profile

• Profile

  平成 6年 群馬大学医学部附属病院 研修医（皮膚科）
  平成 8年 群馬大学大学院 進学
  平成10年 東京農工大学農学部附属家畜病院 国内留学
  平成11年 米国バージニア州立大学内科学リウマチ・アレルギー分野 留学
  平成13年 京都大学医学部附属病院 助手（皮膚科）
  平成19年 千葉大学大学院医学研究院 講師，ついで准教授（皮膚科）
  平成27年 関西医科大学 准教授（皮膚科），附属病院アレルギーセンター 副センター長（兼任）
  令和 2年 京都大学医学部附属病院 特定准教授，ついで大学院医学研究科 准教授（皮膚科）
  令和 5年 京都大学大学院医学研究科 特定教授および京都大学附属病院アレルギーセンター 副センター長（兼任）

ID,URL

• J-Global ID

  201701019849641828

researchmap URL

• https://researchmap.jp/nkambe

Research

Research Interests

• IL-1
• neutrophil
• auto inflammatory syndrome
• mast cells

Research Areas

• Life sciences, Dermatology

Papers

• A case of refractory alopecia areata successfully treated by combining delgocitinib ointment with excimer laser

  Yukito Kakeji; Toshiaki Kogame; Yosuke Yagi; Naotomo Kambe; Kenji Kabashima

  Skin Health and Disease, 07 Apr. 2025

  
• Consideration of useful patient-reported outcome measures to identify unmet medical needs of children and adults with autoimmune and autoinflammatory diseases.

  Shuji Sumitomo; Toru Hirano; Akinori Moriichi; Yuzaburo Inoue; Hidehiko Narazaki; Mitsuyo Inoue; Naoto Yokogawa; Naotomo Kambe; Tomoyuki Mukai; Kazushi Izawa; Dai Kishida; Hajime Yoshifuji; Ken Yamaji; Ryuta Nishikomori; Masaaki Mori; Takako Miyamae

  Modern rheumatology, 05 Apr. 2025

  
• A case of non‐uremic calciphylaxis in a patient with secondary hyperparathyroidism and panhypopituitarism

  Atsushi Naito; Saeko Nakajima; Hiroaki Nakano; Kohdai Furuta; Hiroyuki Irie; Takuro Hakata; Ichiro Yamauchi; Masakazu Fujimoto; Naotomo Kambe; Kenji Kabashima

  The Journal of Dermatology, 04 Feb. 2025

  
• Psoriasiform Dermatitis Following Kawasaki Disease: A Case Report and Literature Review

  Shota Nakayama; Naotomo Kambe; Hiroyuki Irie; Kazushi Izawa; Ryohei Nishijima; Hiroo Ueno; Masakazu Fujimoto; Takahiro Yasumi; Kenji Kabashima

  Pediatric Dermatology, 27 Dec. 2024

  
• Investigator-initiated, multi-center, single-arm, open-label study of the effectiveness of canakinumab in Japanese patients with Schnitzler syndrome

  Naotomo Kambe; Mayuko Yamamoto; Koji Takemura; Shin-ichiro Kagami; Yoshie Kawahara; Hajime Yoshifuji; Tomoyasu Jo; Kazushi Izawa; Satoshi Nakamizo; Norimitsu Inoue; Tatsuya Ito; Yoko Amino; Yumiko Ibi; Satoshi Morita; Nobuo Kanazawa

  Allergology International, Apr. 2025

  
• Current topics on urticaria, and urticaria-related diseases introduced in the Japanese urticaria clinical practice guidelines.

  Naotomo Kambe

  Allergology international : official journal of the Japanese Society of Allergology, Jul. 2023, Lead author, Corresponding author

  
• Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome.

  Yoko Ueki; Riko Takimoto-Ito; Megumu K Saito; Hideaki Tanizaki; Naotomo Kambe

  Frontiers in immunology, 2023, Peer-reviewed, Last author, Corresponding author

  
• A case of hereditary angioedema with acute abdominal pain during postpartum

  Tomoko Matsuda; Naotomo Kambe; Kahori Nakatani; Haruka Goda; Yuki Nomura; Fumikazu Yamazaki; Hiroyuki Okamoto; Takahiko Horiuchi

  Skin Research, 2018

  
• Herpes zoster with acute encephalomyelitis: A case report

  Yoko Ueki; Ikuko Ueda; Noriko Kume; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Satoshi Morise; Masataka Nakamura

  Skin Research, 2020

  
• Two Cases of Autosomal Recessive Woolly Hair/Hypotrichosis with LIPH Gene Mutations

  Kaori Takezawa; Ikuko Ueda; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Yutaka Shimomura

  Skin Research, 2019

  
• A case of discrete papular lichen myxedematosus

  Haruka Goda; Naotomo Kambe; Kaori Kusabiraki; Fumikazu Yamazaki; Hiroyuki Okamoto

  Skin Research, 2019

  
• Two cases of birt-hogg-dubé syndrome conrmed by skin biopsy

  Tomoko Matsuda; Naotomo Kambe; Ikuko Ueda; Fumikazu Yamazaki; Chuyen Thi Hong Nguyen; Hiroyuki Okamoto

  Skin Research, 2017

  
• A sporadic case of blau syndrome diagnosed at an early time point by skin biopsy

  Tomoko Matsuda; Naotomo Kambe; Hiroyuki Okamoto

  Skin Research, 2017

  
• Five cases of necrobiosis lipoidica

  Sayaka Terai; Ikuko Ueda; Noriko Kume; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Jyunko Taki

  Skin Research, 2017

  
• Presence of immunoglobulin E‐expressing antibody‐secreting cells in the dermis close to bullous pemphigoid lesions

  Fatimah Budair; Naotomo Kambe; Toshiaki Kogame; Masahiro Hirata; Riko Takimoto‐Ito; Alshimaa Mostafa; Takashi Nomura; Kenji Kabashima

  Experimental Dermatology, Apr. 2024, Peer-reviewed

  
• Proteasome inhibitor‐associated histiocytoid Sweet's syndrome: Clinical and histological similarities to Nakajo‐Nishimura syndrome suggest a potential mechanism

  Ryang Cho; Saeko Nakajima; Yo Kaku; Junko Tezuka; Masakazu Fujimoto; Naotomo Kambe; Kenji Kabashima

  The Journal of Dermatology, Oct. 2024, Peer-reviewed

  
• Neutrophilic epitheliotropism, proposed as an auto‐inflammatory condition of neutrophilic urticarial dermatosis including Schnitzler syndrome, is also observed in Japanese cases

  Hitomi Nakaizumi; Naotomo Kambe; Hiroyuki Irie; Yo Kaku; Masakazu Fujimoto; Hajime Yoshifuji; Yasuhiro Kazuma; Kazumoto Katagiri; Takuro Kanekura; Kenji Kabashima

  The Journal of Dermatology, Apr. 2024, Peer-reviewed, Corresponding author

  
• A case of post herpes zoster granulomatous dermatitis successfully treated with UVA1 phototherapy

  Atsushi Naito; Toshiaki Kogame; Naotomo Kambe; Kenji Kabashima

  The Journal of Dermatology, Apr. 2024, Peer-reviewed

  
• A case of Kimura disease with atopic dermatitis successfully treated with baricitinib

  Marina Ueda; Toshiaki Kogame; Gyohei Egawa; Naotomo Kambe; Kenji Kabashima

  The Journal of Dermatology, Jun. 2023, Peer-reviewed

  
• Panniculitis in dermatomyositis: Two cases with antitranscriptional intermediary factor‐1 antibody as myositis‐specific antibody and review of the literature

  Kaori Takezawa; Ikuko Ueda‐Hayakawa; Akihiro Tanaka; Yonsu Son; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Manabu Fujimoto

  Journal of Cutaneous Immunology and Allergy, Jun. 2022

  
• Acquired idiopathic generalized anhidrosis following pembrolizumab treatment

  K. Furuta; A. Horiguchi; Y. Nakagawa; N. Kambe; T. Kogame

  Clinical and Experimental Dermatology, Feb. 2022

  
• CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis

  Yoshihiro Ishida; Kazuko Saeki; Marina Ueda; Hyeon‐Cheol Lee‐Okada; Hiromi Doi; Naotomo Kambe; Saeko Nakajima; Takehiko Yokomizo; Kenji Kabashima

  Journal of the European Academy of Dermatology and Venereology, 07 Dec. 2023, Peer-reviewed

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• Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis.

  Satoshi Nakamizo; Yuki Sugiura; Yoshihiro Ishida; Yoko Ueki; Satoru Yonekura; Hideaki Tanizaki; Hiroshi Date; Akihiko Yoshizawa; Teruasa Murata; Kenji Minatoya; Mikako Katagiri; Seitaro Nomura; Issei Komuro; Seishi Ogawa; Saeko Nakajima; Naotomo Kambe; Gyohei Egawa; Kenji Kabashima

  The Journal of clinical investigation, 01 Dec. 2023, Peer-reviewed

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• Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity.

  Kunihiko Moriya; Tomohiro Nakano; Yoshitaka Honda; Miyuki Tsumura; Masato Ogishi; Motoshi Sonoda; Masahiko Nishitani-Isa; Takashi Uchida; Mohamed Hbibi; Yoko Mizoguchi; Masataka Ishimura; Kazushi Izawa; Takaki Asano; Fumihiko Kakuta; Daiki Abukawa; Darawan Rinchai; Peng Zhang; Naotomo Kambe; Aziz Bousfiha; Takahiro Yasumi; Bertrand Boisson; Anne Puel; Jean-Laurent Casanova; Ryuta Nishikomori; Shouichi Ohga; Satoshi Okada; Yoji Sasahara; Shigeo Kure

  The Journal of experimental medicine, 04 Sep. 2023, Peer-reviewed

  
• Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan

  Riko Takimoto-Ito; Naotomo Kambe; Toshiaki Kogame; Takashi Nomura; Kazushi Izawa; Tomoyasu Jo; Yasuhiro Kazuma; Hajime Yoshifuji; Yuya Tabuchi; Hiroyasu Abe; Mayuko Yamamoto; Kimiko Nakajima; Ozumi Tomita; Yosuke Yagi; Kazumoto Katagiri; Yuki Matsuzaka; Yohei Takeuchi; Miho Hatanaka; Takuro Kanekura; Sora Takeuchi; Takafumi Kadono; Yuya Fujita; Kiyoshi Migita; Takahiro Fujino; Takahiko Akagi; Tomoyuki Mukai; Tohru Nagano; Mitsuhiro Kawano; Hayato Kimura; Yukari Okubo; Akimichi Morita; Michihiro Hide; Takahiro Satoh; Akihiko Asahina; Nobuo Kanazawa; Kenji Kabashima

  Allergology International, Dec. 2022, Peer-reviewed, Corresponding author

  
• Ten-year-format diary of fever episodes kept over a five-year period by a patient with familial Mediterranean fever.

  Naotomo Kambe; Riko Takimoto-Ito; Kenji Kabashima

  Clinical and experimental rheumatology, 28 Nov. 2022, Peer-reviewed, Lead author, Corresponding author

  
• Incomplete penetrance of NOD2 C483W mutation underlining Blau syndrome.

  Shao-Yu Chang; Naotomo Kambe; Wen-Lang Fan; Jing-Long Huang; Wen-I Lee; Chao-Yi Wu

  Pediatric rheumatology online journal, 03 Oct. 2022, Peer-reviewed

  
• A New Era with the Development of Cytokine-Based Therapy for Pruritus.

  Rintaro Shibuya; Riko Takimoto-Ito; Naotomo Kambe; Kenji Kabashima

  The Journal of investigative dermatology, Jan. 2022, Peer-reviewed, Invited, Corresponding author

  
• The Potential Role of Basophils in Urticaria.

  Riko Takimoto-Ito; Ni Ma; Izumi Kishimoto; Kenji Kabashima; Naotomo Kambe

  Frontiers in immunology, 2022, Peer-reviewed, Invited, Corresponding author

  
• Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin.

  Izumi Kishimoto; Ni Ma; Riko Takimoto-Ito; Chisa Nakashima; Atsushi Otsuka; Andrew F Walls; Hideaki Tanizaki; Naotomo Kambe

  Frontiers in immunology, 2022, Peer-reviewed, Last author, Corresponding author

  
• Autoinflammatory diseases and the inflammasome: mechanisms of IL-1β activation leading to neutrophil-rich skin disorders

  Kambe Naotomo; Satoh Takashi; Nakamura Yuumi; Iwasawa Mari; Matsue Hiroyuki

  Inflammation and Regeneration, 2011

  
• Exanthem with Cryopyrin Associated Periodic Syndromes and Consideration of IL-1 Targeted Therapy for Neutrophilic Predominant Urticaria

  WANDERER Alan A.; KAMBE Naotomo; NAKAMURA Yuumi

  Allergology International, 01 Sep. 2010

  
• Interleukin-13 inhibition by tralokinumab reduces inducible T-cell costimulator-positive innate lymphoid cells in skin lesions of atopic dermatitis.

  Toshiaki Kogame; Satoru Yonekura; Paola Lovato; Masahiro Hirata; Riko Takimoto-Ito; Tomoya Takegami; Takayoshi Komatsu-Fujii; Naotomo Kambe; Takashi Nomura; Mads A Røpke; Kenji Kabashima

  The British journal of dermatology, 23 Jan. 2023, Peer-reviewed

  
• Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis.

  Tomoko Matsuda; Naotomo Kambe; Riko Takimoto-Ito; Yoko Ueki; Satoshi Nakamizo; Megumu K Saito; Syuji Takei; Nobuo Kanazawa

  Frontiers in immunology, 2022, Peer-reviewed, Invited, Corresponding author

  
• Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience.

  Takayuki Miyamoto; Yoshitaka Honda; Kazushi Izawa; Nobuo Kanazawa; Saori Kadowaki; Hidenori Ohnishi; Masakazu Fujimoto; Naotomo Kambe; Naoya Kase; Takeshi Shiba; Yasuo Nakagishi; Shuji Akizuki; Kosaku Murakami; Masahiro Bamba; Yutaka Nishida; Ayano Inui; Tomoo Fujisawa; Daisuke Nishida; Naomi Iwata; Yoshikazu Otsubo; Shingo Ishimori; Momoko Nishikori; Kiminobu Tanizawa; Tomoyuki Nakamura; Takeshi Ueda; Yoko Ohwada; Yu Tsuyusaki; Masaki Shimizu; Takasuke Ebato; Kousho Iwao; Akiharu Kubo; Toshinao Kawai; Tadashi Matsubayashi; Tatsuhiko Miyazaki; Tomohiro Kanayama; Masahiko Nishitani-Isa; Hiroshi Nihira; Junya Abe; Takayuki Tanaka; Eitaro Hiejima; Satoshi Okada; Osamu Ohara; Megumu K Saito; Junko Takita; Ryuta Nishikomori; Takahiro Yasumi

  Frontiers in immunology, 2022, Peer-reviewed

  
• Anti-BP180, pruritus, and thymus and activation-regulated chemokines as surrogate markers for disease activity in bullous pemphigoid.

  S Wada; T Komori; C S de Jesus; T Nomura; T Komura; S Yonekura; R Shibuya; E Adachi; Y Sakurai; M Ishikawa; S Usui; N Kambe; K Kabashima

  Journal of the European Academy of Dermatology and Venereology : JEADV, 20 Jul. 2022, Peer-reviewed

  
• CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation

  Rintaro Shibuya; Yoshihiro Ishida; Sho Hanakawa; Tatsuki R. Kataoka; Yasuhide Takeuchi; Teruasa Murata; Arisa Akagi; Zachary Chow; Toshiaki Kogame; Satoshi Nakamizo; Saeko Nakajima; Gyohei Egawa; Takashi Nomura; Naotomo Kambe; Akihiko Kitoh; Kenji Kabashima

  Journal of Investigative Dermatology, 2021, Peer-reviewed

  
• Refractory serum immunoglobulin M elevation during anti‐interleukin (IL)‐1‐ or IL‐6‐targeted treatment in four patients with Schnitzler syndrome

  Riko Takimoto‐Ito; Naotomo Kambe; Toshiaki Kogame; Atsushi Otsuka; Takashi Nomura; Kazushi Izawa; Yuya Tabuchi; Hajime Yoshifuji; Yohei Takeuchi; Kenji Kabashima

  The Journal of Dermatology, Nov. 2021, Peer-reviewed, Corresponding author

  
• Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials.

  Xiaoliang Yang; Naotomo Kambe; Riko Takimoto-Ito; Kenji Kabashima

  Pharmacology & therapeutics, Aug. 2021, Peer-reviewed, Invited, Corresponding author

  
• Skin‐associated lymphoid tissue could be a sign of systemic disease: reply from authors

  T. Kogame; N. Kambe; R. Takimoto‐Ito; T. Nomura; K. Kabashima

  British Journal of Dermatology, Jul. 2021, Peer-reviewed, Invited

  
• Hereditary angioedema with a novel mutation, c.1481G>C, in the SERPING1 gene

  Riko Takimoto‐Ito; Naotomo Kambe; Kazushi Izawa; Takahiro Yasumi; Kenji Kabashima

  Journal of Cutaneous Immunology and Allergy, Jun. 2021, Peer-reviewed, Corresponding author

  
• Inducible skin‐associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema

  H. Kamido; D. Shimomiya; T. Kogame; R. Takimoto‐Ito; T.R. Kataoka; M. Hirata; C. Ueshima; A. Otsuka; F.M. Ghazawi; T. Nomura; N. Kambe; K. Kabashima

  British Journal of Dermatology, Jun. 2021, Peer-reviewed

  
• Anti-TNF treatment corrects IFN-γ–dependent proinflammatory signatures in Blau syndrome patient–derived macrophages

  Yohko Kitagawa; Yuri Kawasaki; Yuichi Yamasaki; Naotomo Kambe; Syuji Takei; Megumu K. Saito

  Journal of Allergy and Clinical Immunology, Jun. 2021, Peer-reviewed

  
• Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.

  Mizuho Nishiyama; Hong-Jin Li; Ikuo Okafuji; Akihiko Fujisawa; Mizue Ehara; Naotomo Kambe; Fukumi Furukawa; Nobuo Kanazawa

  Children (Basel, Switzerland), 25 Apr. 2021, Peer-reviewed

  
• NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination.

  Akiko Arakawa; Naotomo Kambe; Ryuta Nishikomori; Akiyo Tanabe; Masamichi Ueda; Chikako Nishigori; Yoshiki Miyachi; Nobuo Kanazawa

  Children (Basel, Switzerland), 06 Feb. 2021, Peer-reviewed

  
• Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas

  Mitsuko Furuya; Yasuhiro Iribe; Yoji Nagashima; Naotomo Kambe; Chisato Ohe; Hidefumi Kinoshita; Chika Sato; Takeshi Kishida; Yoichiro Okubo; Kazuyuki Numakura; Hiroshi Nanjo; Noboru Nakaigawa; Kazuhide Makiyama; Hisashi Hasumi; Hiromichi Iwashita; Junichi Ohta; Hiroshi Kitamura; Takahiko Nakajima; Takahiro Yoshida; Masahiro Nakagawa; Reiko Tanaka; Masahiro Yao

  Journal of Clinical Pathology, Dec. 2020, Peer-reviewed

  
• Hailey–Hailey disease with a novel variant, c.1978dupG, in the ATP2C1 gene

  S. Itsukage; N. Kambe; Y. Ueki; C. Sato; H. Nakano

  Clinical and Experimental Dermatology, 11 Oct. 2020, Peer-reviewed, Corresponding author

  
• Blau Syndrome: NOD2-related systemic autoinflammatory granulomatosis.

  Sanami Takada; Megumu K Saito; Naotomo Kambe

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, Oct. 2020, Peer-reviewed, Invited, Last author, Corresponding author

  
• Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.

  Tomoko Matsuda; Naotomo Kambe; Yoko Ueki; Nobuo Kanazawa; Kazushi Izawa; Yoshitaka Honda; Atsushi Kawakami; Syuji Takei; Kyoko Tonomura; Masami Inoue; Hiroko Kobayashi; Ikuo Okafuji; Yoshihiko Sakurai; Naoki Kato; Yuta Maruyama; Yuzaburo Inoue; Yoshikazu Otsubo; Teruhiko Makino; Satoshi Okada; Ichiro Kobayashi; Masato Yashiro; Shusaku Ito; Hiroshi Fujii; Yasuhiro Kondo; Nami Okamoto; Shuichi Ito; Naomi Iwata; Utako Kaneko; Mototsugu Doi; Junichi Hosokawa; Osamu Ohara; Megumu K Saito; Ryuta Nishikomori

  Annals of the rheumatic diseases, 09 Jul. 2020, Peer-reviewed, Corresponding author

  
• Mastocytosis with sudden recurrence of rash after a 13-year interval.

  Kaori Takezawa; Naotomo Kambe; Yoko Ueki; Saeko Nakajima; Hiroyuki Okamoto

  The Journal of dermatology, 09 Apr. 2020, Peer-reviewed

  
• Circulating intermediate monocytes produce TARC in sarcoidosis

  Izumi Kishimoto; Chuyen Thi Hong Nguyen; Naotomo Kambe; Nhung Thi My Ly; Yoko Ueki; Ikuko Ueda-Hayakawa; Hiroyuki Okamoto

  Allergology International, Apr. 2020, Peer-reviewed, Corresponding author

  
• Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms.

  Hanna Bonnekoh; Monique Butze; Tilmann Kallinich; Naotomo Kambe; Georgios Kokolakis; Karoline Krause

  Acta dermato-venereologica, 25 Mar. 2020, Peer-reviewed

  
• Successful treatment with hydroxychloroquine for systemic lupus erythematosus with cutaneous involvement accompanied by a xanthomatous reaction

  Takezawa, K.; Ueda-Hayakawa, I.; Yamazaki, F.; Kambe, N.; Son, Y.; Okamoto, H.

  Lupus, Jan. 2020, Peer-reviewed

  
• Hydroxychloroquine for the treatment of lupus erythematosus with cutaneous involvement: clinical efficacy and serial analysis of anti-DNA antibody levels

  Ikuko Ueda-Hayakawa; Nhung Thi My Ly; Chuyen Thi Hong Nguyen; Tomoko Matsuda; Fumikazu Yamazaki; Naotomo Kambe; Yonsu Son; Hiroyuki Okamoto

  European Journal of Dermatology, Oct. 2019, Peer-reviewed

  
• Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: Mosaicism in systemic autoinflammatory diseases

  Nishikomori, R.; Izawa, K.; Kambe, N.; Ohara, O.; Yasumi, T.

  International Immunology, Oct. 2019, Peer-reviewed, Invited

  
• Sweet syndrome in a patient with chronic myelogenous leukemia under dasatinib treatment.

  Matsuda T; Ueda-Hayakawa I; Kambe N; Fujita S; Okamoto H

  The Journal of Dermatology, Apr. 2019, Peer-reviewed

  
• Hereditary leiomyomatosis and renal cell cancer syndrome in which skin biopsy enabled diagnosis.

  Matsuda T; Kambe N; Ly NTM; Ueda-Hayakawa I; Yamazaki F; Ohe C; Yoshida K; Kinoshita H; Furuya M; Okamoto H

  The Journal of Dermatology, Mar. 2019, Peer-reviewed, Corresponding author

  
• Basophil count is a sensitive marker for clinical progression in a chronic spontaneous urticaria patient treated with omalizumab

  Kishimoto, I.; Kambe, N.; Ly, N.T.M.; Nguyen, C.T.H.; Okamoto, H.

  Allergology International, Feb. 2019, Peer-reviewed, Corresponding author

  
• Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin-17A, but improved after blockade of interleukin-12/23 p40.

  Matsuda T; Yamazaki F; Ueda-Hayakawa I; Kambe N; Okamoto H

  The Journal of Dermatology, Jan. 2019, Peer-reviewed

  
• Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model.

  Oishi N; Iwata H; Kambe N; Kobayashi N; Fujimoto K; Sato H; Hisaka A; Ueno K; Yamaura K

  Heliyon, 2019, Peer-reviewed

  
• Four cases of anti-Mi-2 antibody-positive dermatomyositis: relationship between anti-Mi-2 antibody titre and disease severity and activity

  T. Matsuda; I. Ueda-Hayakawa; N. Kambe; Y. Son; Y. Ozaki; Y. Hamaguchi; K. Takehara; M. Fujimoto; H. Okamoto

  Journal of the European Academy of Dermatology and Venereology, 01 Jun. 2018, Peer-reviewed

  
• Up-regulated expression of CD86 on circulating intermediate monocytes correlated with disease severity in psoriasis

  Chuyen Thi Hong Nguyen; Naotomo Kambe; Fumikazu Yamazaki; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Hiroyuki Okamoto

  Journal of Dermatological Science, 01 May 2018, Peer-reviewed

  
• The role of mast cells in autoinflammation

  Hanna Bonnekoh; Jörg Scheffel; Naotomo Kambe; Karoline Krause

  Immunological Reviews, 01 Mar. 2018, Peer-reviewed

  
• Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work

  Tomoko Matsuda; Nhung Thi My Ly; Naotomo Kambe; Chuyen Thi Hong Nguyen; Ikuko Ueda-Hayakawa; Yonsu Son; Hiroyuki Okamoto

  Journal of Dermatology, 01 Mar. 2018, Peer-reviewed

  
• TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis

  Chuyen Thi Hong Nguyen; Naotomo Kambe; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Nhung Thi My Ly; Kana Mizuno; Hiroyuki Okamoto

  Allergology International, 2018, Peer-reviewed

  
• Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163+ M2 macrophages in two cases, and a review of published works

  Terai S; Ueda-Hayakawa I; Nguyen CTH; Ly NTM; Yamazaki F; Kambe N; Son Y; Okamoto H

  Lupus, 2018, Peer-reviewed

  
• Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.

  Sanami Takada; Naotomo Kambe; Yuri Kawasaki; Akira Niwa; Fumiko Honda-Ozaki; Kazuki Kobayashi; Mitsujiro Osawa; Ayako Nagahashi; Katsunori Semi; Akitsu Hotta; Isao Asaka; Yasuhiro Yamada; Ryuta Nishikomori; Toshio Heike; Hiroyuki Matsue; Tatsutoshi Nakahata; Megumu K Saito

  The Journal of allergy and clinical immunology, Jan. 2018, Peer-reviewed

  
• A sporadic case of granulomatous disease negative for NOD2 mutations and mimicking Blau syndrome

  F. Oda; M. Murakami; Y. Hanakawa; M. Tohyama; N. Nakano; R. Nishikomori; N. Kambe; K. Sayama

  CLINICAL AND EXPERIMENTAL DERMATOLOGY, Jan. 2018, Peer-reviewed

  
• Protein contact dermatitis induced by cabbage with recurrent symptoms after oral intake

  Izumi Kishimoto; Naotomo Kambe; Chuyen T. H. Nguyen; Tomoko Matsuda; Yuki Nomura; Naoko Uetsu; Hiroyuki Okamoto

  JOURNAL OF DERMATOLOGY, Oct. 2017, Peer-reviewed

  
• Serum soluble interleukin-2 receptor level is more sensitive than angiotensin-converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement

  Chuyen Thi Hong Nguyen; Naotomo Kambe; Izumi Kishimoto; Ikuko Ueda-Hayakawa; Hiroyuki Okamoto

  JOURNAL OF DERMATOLOGY, Jul. 2017, Peer-reviewed

  
• Psoriatic skin lesions induced by abatacept: Case report and review of the published work

  Ikuko Ueda-Hayakawa; Chuyen Nguyen Thi Hong; Yoko Ueki; Naotomo Kambe; Hiroyuki Okamoto

  JOURNAL OF DERMATOLOGY, Jul. 2017, Peer-reviewed

  
• Innate immunity

  Takashi Satoh; Naotomo Kambe

  Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses, 01 Jan. 2016, Peer-reviewed

  
• The role of group IIF-secreted phospholipase A(2) in epidermal homeostasis and hyperplasia

  Kei Yamamoto; Yoshimi Miki; Mariko Sato; Yoshitaka Taketomi; Yasumasa Nishito; Choji Taya; Kazuaki Muramatsu; Kazutaka Ikeda; Hiroki Nakanishi; Ryo Taguchi; Naotomo Kambe; Kenji Kabashima; GeRard Lambeau; Michael H. Gelb; Makoto Murakami

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 2015, Peer-reviewed

  
• Case of respiratory discomfort due to myositis after administration of nivolumab

  Miri Yoshioka; Naotomo Kambe; Yosuke Yamamoto; Keisuke Suehiro; Hiroyuki Matsue

  JOURNAL OF DERMATOLOGY, Oct. 2015, Peer-reviewed

  
• Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes

  Kenji Nakagawa; Eva Gonzalez-Roca; Alejandro Souto; Toshinao Kawai; Hiroaki Umebayashi; Josep Maria Campistol; Jeronima Canellas; Syuji Takei; Norimoto Kobayashi; Jose Luis Callejas-Rubio; Norberto Ortego-Centeno; Estibaliz Ruiz-Ortiz; Fina Rius; Jordi Anton; Estibaliz Iglesias; Santiago Jimenez-Trevino; Carmen Vargas; Julian Fernandez-Martin; Inmaculada Calvo; Jose Hernandez-Rodriguez; Maria Mendez; Maria Teresa Dordal; Maria Basagana; Segundo Bujan; Masato Yashiro; Tetsuo Kubota; Ryuji Koike; Naoko Akuta; Kumiko Shimoyama; Naomi Iwata; Megumu K. Saito; Osamu Ohara; Naotomo Kambe; Takahiro Yasumi; Kazushi Izawa; Tomoki Kawai; Toshio Heike; Jordi Yaguee; Ryuta Nishikomori; Juan I. Arostegui

  ANNALS OF THE RHEUMATIC DISEASES, Mar. 2015, Peer-reviewed

  
• Successful treatment of Group A beta-hemolytic Streptococcus infection-associated juvenile cutaneous polyarteritis nodosa with tonsillectomy

  Takeshi Yamamoto; Yuzaburo Inoue; Minako Tomiita; Makiko Oikawa; Naotomo Kambe; Takayasu Arima; Naoki Shimojo; Yoichi Kohno

  MODERN RHEUMATOLOGY, 2015, Peer-reviewed

  
• Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: A randomized, double-blind, placebo-controlled, crossover pilot study

  Yaei Togawa; Naotomo Kambe; Naoki Shimojo; Taiji Nakano; Yasunori Sato; Hiroyuki Mochizuki; Akane Tanaka; Hiroshi Matsuda; Hiroyuki Matsue

  JOURNAL OF DERMATOLOGICAL SCIENCE, Dec. 2014, Peer-reviewed

  
• Oculocutaneous albinism (OCA) in Japanese patients: Five novel mutations

  Ken Okamura; Junko Yoshizawa; Yuko Abe; Keiko Hanaoka; Naoyuki Higashi; Yaei Togawa; Seitaro Nakagawa; Naotomo Kambe; Yoko Funasaka; Kentaro Ohko; Yutaka Hozumi; Tamio Suzuki

  JOURNAL OF DERMATOLOGICAL SCIENCE, May 2014, Peer-reviewed

  
• Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome

  Kei Ikeda; Naotomo Kambe; Syuji Takei; Taiji Nakano; Yuzaburo Inoue; Minako Tomiita; Natsuko Oyake; Takashi Satoh; Tsuyoshi Yamatou; Tomohiro Kubota; Ikuo Okafuji; Nobuo Kanazawa; Ryuta Nishikomori; Naoki Shimojo; Hiroyuki Matsue; Hiroshi Nakajima

  ARTHRITIS RESEARCH & THERAPY, 2014, Peer-reviewed

  
• Preferentially inflamed tendon sheaths in the swollen but not tender joints in a 5-year-old boy with blau syndrome

  Kei Ikeda; Naotomo Kambe; Takashi Satoh; Hiroyuki Matsue; Hiroshi Nakajima

  Journal of Pediatrics, Nov. 2013, Peer-reviewed

  
• Alteration of circulating miRNAs in SSc: MiR-30b regulates the expression of PDGF receptor β

  Shigeru Tanaka; Akira Suto; Kei Ikeda; Yoshie Sanayama; Daiki Nakagomi; Taro Iwamoto; Kotaro Suzuki; Naotomo Kambe; Hiroyuki Matsue; Ryutaro Matsumura; Daisuke Kashiwakuma; Itsuo Iwamoto; Hiroshi Nakajima

  Rheumatology (United Kingdom), Nov. 2013, Peer-reviewed

  
• Linkage of bacterial colonization of skin and the urticaria like rash of NLRP3 mediated autoinflammatory syndromes through mast cell derived TNF α

  Yuumi Nakamura; Naotomo Kambe

  Journal of Dermatological Science, Aug. 2013, Peer-reviewed

  
• Monogenic early-onset sarcoidosis is no longer a variant of "idiopathic" sarcoidosis

  Nobuo Kanazawa; Georgi Tchernev; Naotomo Kambe

  JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Jul. 2013, Peer-reviewed

  
• Three school-age cases of xeroderma pigmentosum variant type

  Ryusuke Ono; Taro Masaki; Seiji Takeuchi; Ayako Shimizu; Miki Tanioka; Naotomo Kambe; Hiroyuki Matsue; Ryoichi Kamide; Chikako Nishigori

  PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, Jun. 2013, Peer-reviewed

  
• Mast cell maturation is driven via a group III phospholipase A(2)-prostaglandin D-2-DP1 receptor paracrine axis

  Yoshitaka Taketomi; Noriko Ueno; Takumi Kojima; Hiroyasu Sato; Remi Murase; Kei Yamamoto; Satoshi Tanaka; Mariko Sakanaka; Masanori Nakamura; Yasumasa Nishito; Momoko Kawana; Naotomo Kambe; Kazutaka Ikeda; Ryo Taguchi; Satoshi Nakamizo; Kenji Kabashima; Michael H. Gelb; Makoto Arita; Takehiko Yokomizo; Motonao Nakamura; Kikuko Watanabe; Hiroyuki Hirai; Masataka Nakamura; Yoshimichi Okayama; Chisei Ra; Kosuke Aritake; Yoshihiro Urade; Kazushi Morimoto; Yukihiko Sugimoto; Takao Shimizu; Shuh Narumiya; Shuntaro Hara; Makoto Murakami

  NATURE IMMUNOLOGY, Jun. 2013, Peer-reviewed

  
• NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation

  T. Satoh; N. Kambe; H. Matsue

  CELL DEATH & DISEASE, May 2013, Peer-reviewed

  
• Novel R218X mutation in the fumarate hydratase gene in a patient with Reed's syndrome

  Fumi Akita; Naotomo Kambe; Michiyo Nakano; Takashi Satoh; Mari Iwasawa; Yaei Togawa; Hiroyuki Matsue

  JOURNAL OF DERMATOLOGY, Jan. 2013, Peer-reviewed

  
• Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism

  Mari T. Iwasawa; Yaei Togawa; Fumi Akita; Naotomo Kambe; Hiroyuki Matsue; Takashi Yaguchi; Kazuko Nishimura

  MEDICAL MYCOLOGY, Oct. 2012, Peer-reviewed

  
• Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

  Takayuki Tanaka; Kazutoshi Takahashi; Mayu Yamane; Shota Tomida; Saori Nakamura; Koichi Oshima; Akira Niwa; Ryuta Nishikomori; Naotomo Kambe; Hideki Hara; Masao Mitsuyama; Nobuhiro Morone; John E. Heuser; Takuya Yamamoto; Akira Watanabe; Aiko Sato-Otsubo; Seishi Ogawa; Isao Asaka; Toshio Heike; Shinya Yamanaka; Tatsutoshi Nakahata; Megumu K. Saito

  BLOOD, Aug. 2012, Peer-reviewed

  
• Critical Role for Mast Cells in Interleukin-1 beta-Driven Skin Inflammation Associated with an Activating Mutation in the NIrp3 Protein

  Yuumi Nakamura; Luigi Franchi; Naotomo Kambe; Guangxun Meng; Warren Strober; Gabriel Nunez

  IMMUNITY, Jul. 2012, Peer-reviewed

  
• Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget's Disease to Trastuzumab Monotherapy

  Wakabayashi S; Togawa Y; Yoneyama K; Suehiro K; Kambe N; Matsue H

  Case Rep Dermatol Med., Mar. 2012, Peer-reviewed

  
• Maximum growth temperature test for cutaneous Mycobacterium chelonae predicts the efficacy of thermal therapy

  Rena Ota; Mari T. Iwasawa; Kiyofumi Ohkusu; Naotomo Kambe; Hiroyuki Matsue

  JOURNAL OF DERMATOLOGY, Feb. 2012, Peer-reviewed

  
• The CD40-CD40L axis and IFN-gamma play critical roles in Langhans giant cell formation

  Hidemasa Sakai; Ikuo Okafuji; Ryuta Nishikomori; Junya Abe; Kazushi Izawa; Naotomo Kambe; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike

  INTERNATIONAL IMMUNOLOGY, Jan. 2012, Peer-reviewed

  
• High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome Results of an International Multicenter Collaborative Study

  Naoko Tanaka; Kazushi Izawa; Megumu K. Saito; Mio Sakuma; Koichi Oshima; Osamu Ohara; Ryuta Nishikomori; Takeshi Morimoto; Naotomo Kambe; Raphaela Goldbach-Mansky; Ivona Aksentijevich; Genevieve de Saint Basile; Benedicte Neven; Marielle van Gijn; Joost Frenkel; Juan I. Arostegui; Jordi Yaguee; Rosa Merino; Mercedes Ibanez; Alessandra Pontillo; Hidetoshi Takada; Tomoyuki Imagawa; Tomoki Kawai; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike

  ARTHRITIS AND RHEUMATISM, Nov. 2011, Peer-reviewed

  
• Identification of 736T > A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair

  Takashi Yoshimasu; Nobuo Kanazawa; Naotomo Kambe; Motonobu Nakamura; Fukumi Furukawa

  JOURNAL OF DERMATOLOGY, Sep. 2011, Peer-reviewed

  
• Follicular keratosis and bullous formation are typical signs of extragenital lichen sclerosus

  Ayako Kimura; Naotomo Kambe; Takashi Satoh; Yaei Togawa; Keisuke Suehiro; Hiroyuki Matsue

  JOURNAL OF DERMATOLOGY, Aug. 2011, Peer-reviewed

  
• Lymphocutaneous Type of Nocardiosis Caused by Nocardia vinacea in a Patient with Polymyositis

  Mari T. Iwasawa; Yaei Togawa; Noriaki Kamada; Naotomo Kambe; Hiroyuki Matsue; Katsukiyo Yazawa; Takashi Yaguchi; Yuzuru Mikami

  MYCOPATHOLOGIA, Jul. 2011, Peer-reviewed

  
• Dermoscopy of keratosis follicularis squamosa

  Michiyo Nakano; Naotomo Kambe; Takashi Satoh; Yaei Togawa; Noriaki Kamada; Hiroyuki Matsue

  Dermatology Reports, 2011, Peer-reviewed

  
• Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature

  Y. Togawa; Y. Nakamura; N. Kamada; N. Kambe; Y. Takahashi; H. Matsue

  INTERNATIONAL JOURNAL OF DERMATOLOGY, Dec. 2010, Peer-reviewed

  
• Enhanced NF-kappa B activation with an inflammasome activator correlates with activity of autoinflammatory disease associated with NLRP3 mutations outside of exon 3: comment on the article by Jeru et al

  Naotomo Kambe; Takashi Satoh; Hideaki Tanizaki; Akihiro Fujisawa; Megumu K. Saito; Ryuta Nishikomori

  ARTHRITIS AND RHEUMATISM, Oct. 2010, Peer-reviewed

  
• The inflammasome, an innate immunity guardian, participates in skin urticarial reactions and contact hypersensitivity

  Naotomo Kambe; Yuumi Nakamura; Megumu Saito; Ryuta Nishikomori

  Allergology International, 2010, Peer-reviewed

  
• Mastocytosis

  Naotomo Kambe; Akane Tanaka; Yoshiki Miyachi

  Therapy of Skin Diseases: A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis, 2010, Peer-reviewed

  
• Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly

  Y. Nakamura; N. Kambe; N. Deguchi; T. Kawamura; N. Shibagaki; H. Matsue; S. Shimada

  CLINICAL AND EXPERIMENTAL DERMATOLOGY, Oct. 2009, Peer-reviewed

  
• Murine Fetal Skin-Derived Cultured Mast Cells: A Useful Tool for Discovering Functions of Skin Mast Cells

  Hiroyuki Matsue; Naotomo Kambe; Shinji Shimada

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2009, Peer-reviewed

  
• Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

  Yuumi Nakamura; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Yun-Gi Kim; Makoto Murakami; Gabriel Nunez; Hiroyuki Matsue

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2009, Peer-reviewed

  
• Role of the NOD2 Genotype in the Clinical Phenotype of Blau Syndrome and Early-Onset Sarcoidosis

  Ikuo Okafuji; Ryuta Nishikomori; Nobuo Kanazawa; Naotomo Kambe; Akihiro Fujisawa; Shin Yamazaki; Megumu Saito; Takakazu Yoshioka; Tomoki Kawai; Hidemasa Sakai; Hideaki Tanizaki; Toshio Heike; Yoshiki Miyachi; Tatsutoshi Nakahata

  ARTHRITIS AND RHEUMATISM, Jan. 2009, Peer-reviewed

  
• Erythema elevatum diutinum with primary Sjogren syndrome associated with IgA antineutrophil cytoplasmic antibody

  S. Shimizu; Y. Nakamura; Y. Togawa; N. Kamada; N. Kambe; H. Matsue

  BRITISH JOURNAL OF DERMATOLOGY, Sep. 2008, Peer-reviewed

  
• Cryogloblinaemia type I: serum cryoprecipitate formation at 25 degrees C

  Y. Yagi; M. Tanioka; N. Kambe; Y. Matsumura; S. Kore-eda; A. Utani; Y. Miyachi; M. Kato

  CLINICAL AND EXPERIMENTAL DERMATOLOGY, May 2008, Peer-reviewed

  
• Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells

  Akiko Nagasaka; Hiroyuki Matsue; Hironori Matsushima; Rui Aoki; Yuumi Nakamura; Naotomo Kambe; Shigeyuki Kon; Toshimitsu Uede; Shinji Shimada

  EUROPEAN JOURNAL OF IMMUNOLOGY, Feb. 2008, Peer-reviewed

  
• Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients

  Megumu Saito; Ryuta Nishikomori; Naotomo Kambe; Akihiro Fujisawa; Hideaki Tanizaki; Kyoko Takeichi; Tomoyuki Imagawa; Tomoko Iehara; Hidetoshi Takada; Tadashi Matsubayashi; Hiroshi Tanaka; Hisashi Kawashima; Kiyoshi Kawakami; Shinji Kagami; Ikuo Okafuji; Takakazu Yoshioka; Souichi Adachi; Toshio Heike; Yoshiki Miyachi; Tatsutoshi Nakahata

  BLOOD, Feb. 2008, Peer-reviewed

  
• Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice

  Hideaki Tanizaki; Naotomo Kambe; Yuumi Nakamura; Akane Tanaka; Hiroshi Matsuda; Yoshiki Miyachi

  INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2008, Peer-reviewed

  
• Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy

  Hiroko Fujii; Naotomo Kambe; Akihiro Fujisawa; Kunie Kohno; Eishin Morita; Yoshiki Miyachi

  Allergology International, 2008, Peer-reviewed

  
• Direct development of functionally mature tryptase/chymase double-positive connective tissue-type mast cells from primate embryonic stem cells

  Feng Ma; Naotomo Kambe; Dan Wang; Gen Shinoda; Hisanori Fujino; Katsutsugu Umeda; Akihiro Fujisawa; Lina Ma; Hirofumi Suemori; Norio Nakatsuji; Yoshiki Miyachi; Ryuzo Torii; Kohichiro Tsuji; Toshio Heike; Tatsutoshi Nakahataa

  STEM CELLS, 2008, Peer-reviewed

  
• Chemical burn caused by glycidyl methacrylate

  Ayako Shimizu; Noriaki Kamada; Naotomo Kambe; Hiroyuki Matsue

  CONTACT DERMATITIS, 2008, Peer-reviewed

  
• Multiple dermatomal daughter lesions of postzoster granuloma

  E. Araki; N. Kambe; K. Takahashi; Y. Miyachi; A. Utani

  BRITISH JOURNAL OF DERMATOLOGY, Jun. 2007, Peer-reviewed

  
• Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells

  Akihiro Fujisawa; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Hideaki Tanizaki; Nobuo Kanazawa; Souichi Adachi; Toshio Heike; Junji Sagara; Takashi Suda; Tatsutoshi Nakahata; Yoshiki Miyachi

  BLOOD, Apr. 2007, Peer-reviewed, Corresponding author

  
• Involvement of OX40 ligand(+) mast cells in chronic GVHD after allogeneic hematopoietic stem cell transplantation

  A. Kotani; T. Hori; T. Fujita; N. Kambe; Y. Matsumura; T. Ishikawa; Y. Miyachi; K. Nagai; Y. Tanaka; T. Uchiyama

  BONE MARROW TRANSPLANTATION, Mar. 2007, Peer-reviewed

  
• IgE-activated mast cells in combination with pro-inflammatory factors induce T(h)2-promoting dendritic cells

  Toshio Kitawaki; Norimitsu Kadowaki; Naoshi Sugimoto; Naotomo Kambe; Toshiyuki Hori; Yoshiki Miyachi; Tatsutoshi Nakahata; Takashi Uchiyama

  INTERNATIONAL IMMUNOLOGY, Dec. 2006, Peer-reviewed

  
• Type I interferons attenuate T cell activating functions of human mast cells by decreasing TNF-alpha production and OX40 ligand expression while increasing IL-10 production

  Tomoko Fujita; Naotomo Kambe; Takashi Uchiyama; Toshiyuki Hori

  JOURNAL OF CLINICAL IMMUNOLOGY, Nov. 2006, Peer-reviewed

  
• Gene expression profiling of human mast cell subtypes: An in silico study

  Hirohisa Saito; Kenji Matsumoto; Shigeru Okumura; Jun-Ichi Kashiwakura; Keisuke Oboki; Hidenori Yokoi; Naotomo Kambe; Ken Ohta; Yoshimichi Okayama

  Allergology International, 2006, Peer-reviewed

  
• High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: Results of an international multicenter collaborative study

  Tanaka N; Izawa K; Saito MK; Sakuma M; Oshima K; Ohara O; Nishikomori R; Morimoto T; Kambe N; Goldbach-Mansky R; Aksentijevich I; de Saint; Basile G; Neven B; van Gijn M; Frenkel J; Aróstegui JI; Yagüe J; Merino R; Ibañez M; Pontillo A; Takada H; Imagawa T; Kawai T; Yasumi T; Nakahata T; Heike T

  Arthritis Rheum 63(3625-3632), Nov. 2005, Peer-reviewed

  
• Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome

  M Saito; A Fujisawa; R Nishikomori; N Kambe; M Nakata-Hizume; M Yoshimoto; K Ohmori; Okafuji, I; T Yoshioka; T Kusunoki; Y Miyachi; T Heike; T Nakahata

  ARTHRITIS AND RHEUMATISM, Nov. 2005, Peer-reviewed

  
• The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders

  N Kambe; R Nishikomori; N Kanazawa

  JOURNAL OF DERMATOLOGICAL SCIENCE, Aug. 2005, Peer-reviewed

  
• A novel NF-kappa B inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

  A Tanaka; M Konno; S Muto; N Kambe; E Morii; T Nakahata; A Itai; H Matsuda

  BLOOD, Mar. 2005, Peer-reviewed

  
• Stem cell factor has a suppressive activity to IgE-mediated chemotaxis of mast cells

  J Sawada; S Shimizu; T Tamatani; S Kanegasaki; H Saito; A Tanaka; N Kambe; T Nakahata; H Matsuda

  JOURNAL OF IMMUNOLOGY, Mar. 2005, Peer-reviewed

  
• Erythema multiforme due to progesterone in a low-dose oral contraceptive pill

  R Suzuki; Y Matsumura; N Kambe; H Fujii; T Tachibana; Y Miyachi

  BRITISH JOURNAL OF DERMATOLOGY, Feb. 2005, Peer-reviewed

  
• Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappa B activation: common genetic etiology with Blau syndrome

  N Kanazawa; Okafuji, I; N Kambe; R Nishikomori; M Nakata-Hizume; S Nagai; A Fuji; T Yuasa; A Manki; Y Sakurai; M Nakajima; H Kobayashi; L Fujiwara; H Tsutsumi; A Utani; C Nishigori; T Heike; T Nakahata; Y Miyachi

  BLOOD, Feb. 2005, Peer-reviewed

  
• Suplatast tosilate inhibits human mast cell development from cord blood progenitors

  Akihiro Fujisawa; Naotomo Kambe; Tatsutoshi Nakahata; Hiroshi Matsuda; Yoshiki Miyachi

  Allergology International, 2005, Peer-reviewed

  
• Pustular neutrophilic dermatoses and rapidly growing mycobacterium infection with bilateral cervical lymphadenopathy

  A Fujisawa; Y Matsumura; N Kambe; H Fujii; T Tachibana; T Mio; A Takahashi; Y Miyachi

  DERMATOLOGY, 2005, Peer-reviewed

  
• Presence of a sporadic case of systemic granulomatosis syndrome with a CARD15 mutation

  N Kanazawa; S Matsushima; N Kambe; T Tachibana; S Nagai; Y Miyachi

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 2004, Peer-reviewed

  
• Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body

  N Kambe; H Hiramatsu; M Shimonaka; H Fujino; R Nishikomori; T Heike; M Ito; K Kobayashi; Y Ueyama; N Matsuyoshi; Y Miyachi; T Nakahata

  BLOOD, Feb. 2004, Peer-reviewed, Lead author

  
• An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells

  A Tanaka; U Wakita; N Kambe; T Iwasaki; H Matsuda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2004, Peer-reviewed

  
• What is the physiological function of mast cells?

  M Maurer; T Theoharides; RD Granstein; SC Bischoff; J Bienenstock; B Henz; P Kovanen; AM Piliponsky; N Kambe; H Vliagoftis; F Levi-Schaffer; M Metz; Y Miyachi; D Befus; P Forsythe; Y Kitamura; S Galli

  EXPERIMENTAL DERMATOLOGY, Dec. 2003, Peer-reviewed

  
• Commentary 9

  Naotomo Kambe; Yoshiki Miyachi

  Experimental Dermatology, Dec. 2003, Peer-reviewed

  
• Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3(+) cells from umbilical cord blood and CD3(+) cells enhance Fc epsilon R1 expression on fetal liver-derived mast cells in the presence of rhIL-4

  E Lee; HK Min; CA Oskeritzian; N Kambe; LB Schwartz; HW Chang

  CELLULAR IMMUNOLOGY, Nov. 2003, Peer-reviewed

  
• Degranulation and cytokine expression in human cord blood-derived mast cells cultured in serum-free medium with recombinant human stem cell factor

  TC Moon; E Lee; SH Baek; M Murakami; Kudo, I; NS Kim; JM Lee; HK Min; N Kambe; HW Chang

  MOLECULES AND CELLS, Oct. 2003, Peer-reviewed

  
• Ion channel gene expression in human lung, skin, and cord blood-derived mast cells

  P Bradding; Y Okayama; N Kambe; H Saito

  JOURNAL OF LEUKOCYTE BIOLOGY, May 2003, Peer-reviewed

  
• Late-phase urticaria Update.

  Kambe, N.; Kitao, A.; Nishigori, C.; Miyachi, Y.

  Current allergy and asthma reports, Jul. 2002, Peer-reviewed

  
• A possible mechanism of mast cell proliferation in mastocytosis

  N Kambe; Y Miyachi

  JOURNAL OF DERMATOLOGY, Jan. 2002, Peer-reviewed, Lead author

  
• IL-6 attenuates apoptosis, while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells

  M Kambe; N Kambe; CA Oskeritzian; N Schechter; LB Schwartz

  CLINICAL AND EXPERIMENTAL ALLERGY, Jul. 2001, Peer-reviewed

  
• Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes

  N Kambe; M Kambe; JP Kochan; LB Schwartz

  BLOOD, Apr. 2001, Peer-reviewed, Lead author

  
• Human mouse mast cell protease 7-like tryptase genes are pseudogenes

  HK Min; N Kambe; LB Schwartz

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001, Peer-reviewed

  
• Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells

  SL Ren; N Kambe; ZM Du; YL Li; HZ Xia; M Kambe; E Bieberich; A Pozez; M Grimes; RK Yu; AM Irani; LB Schwartz

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001, Peer-reviewed

  
• Nerve growth factor prevents apoptosis of cord blood-derived human cultured mast cells synergistically with stem cell factor

  N Kanbe; M Kurosawa; Y Miyachi; M Kanbe; H Saitoh; H Matsuda

  CLINICAL AND EXPERIMENTAL ALLERGY, Aug. 2000, Peer-reviewed, Lead author

  
• Production of fibrogenic cytokines by cord blood-derived cultured human mast cells

  N Kanbe; M Kurosawa; H Nagata; T Yamashita; F Kurimoto; Y Miyachi

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jul. 2000, Peer-reviewed

  
• An improved procedure for the development of human mast cells from dispersed fetal liver cells in serum-free culture medium

  N Kambe; M Kambe; HW Chang; A Matsui; HK Min; M Hussein; CA Oskerizian; J Kochan; AMA Irani; LB Schwartz

  JOURNAL OF IMMUNOLOGICAL METHODS, Jun. 2000, Peer-reviewed

  
• Nerve growth factor release with mast-cell-derived mediators in a patient with systemic mastocytosis after middle-wave ultraviolet irradiation

  M Kurosawa; H Inamura; H Amano; N Kanbe; H Nagata; H Nagai; S Furukawa; Y Miyachi

  ALLERGY, Sep. 1999, Peer-reviewed

  
• Human mast cells produce matrix metalloproteinase 9

  N Kanbe; A Tanaka; M Kanbe; A Itakura; M Kurosawa; H Matsuda

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 1999, Peer-reviewed, Lead author

  
• Cord-blood-derived human cultured mast cells produce interleukin 13 in the presence of stem cell factor

  N Kanbe; M Kurosawa; T Yamashita; F Kurimoto; Y Yanagihara; Y Miyachi

  INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Jun. 1999, Peer-reviewed, Lead author

  
• Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis

  M Kurosawa; H Amano; N Kanbe; Y Igarashi; H Nagata; T Yamashita; F Kurimoto; Y Miyachi

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, May 1999, Peer-reviewed

  
• Cord blood-derived human cultured mast cells produce transforming growth factor beta(1)

  N Kanbe; M Kurosawa; H Nagata; H Saitoh; Y Miyachi

  CLINICAL AND EXPERIMENTAL ALLERGY, Jan. 1999, Peer-reviewed

  
• Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils

  M Inoue; N Kanbe; M Kurosawa; H Kido

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1998, Peer-reviewed

  
• Idiopathic hypereosinophilic syndrome associated with elevated plasma levels of interleukin-10 and soluble interleukin-2 receptor

  N Kanbe; M Kurosawa; N Igarashi; A Tamura; T Yamashita; F Kurimoto; Y Miyachi

  BRITISH JOURNAL OF DERMATOLOGY, Nov. 1998, Peer-reviewed, Lead author, Corresponding author

  
• Carnoy's fixative reduces the number of chymase-positive cells in immunocytochemical staining of cord-blood-derived human cultured mast cells

  N Kanbe; M Kurosawa; Y Miyachi; M Kanbe; D Kempuraj; H Tachimoto; H Saito

  ALLERGY, Oct. 1998, Peer-reviewed, Lead author

  
• Phase-contrast microscopic studies using cinematographic techniques and scanning electron microscopy on IgE-mediated degranulation of cultured human mast cells

  M Kurosawa; H Inamura; N Kanbe; Y Igarashi; T Tomita; J Takeda; Y Miyachi

  CLINICAL AND EXPERIMENTAL ALLERGY, Aug. 1998, Peer-reviewed

  
• Systemic plasmacytosis with deposition of interleukin (IL)-6 and elevated expression of IL-6 mRNA in the skin lesions

  N Kanbe; M Kurosawa; S Akimoto; D Sugiyama; J Tamura; Y Hirao; Y Miyachi

  BRITISH JOURNAL OF DERMATOLOGY, Apr. 1998, Peer-reviewed, Lead author, Corresponding author

  
• Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis

  M Kurosawa; H Amano; N Kanbe; S Akimoto; Y Takeuchi; T Yamashita; T Hashimoto; F Kurimoto; Y Miyachi

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Dec. 1997, Peer-reviewed

  
• 65-kilodalton protein phosphorylation in human peripheral blood eosinophils

  M Kurosawa; Y Shimizu; Y Igarashi; H Amano; N Kanbe; Y Matsushima; O Ishikawa; Y Miyachi

  INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, Peer-reviewed

  
• Papulonecrotic tuberculid: Positive culture of Mycobacterium tuberculosis from colonic fluid but no identification of its DNA in the skin lesion

  O Ishikawa; C Iijima; N Kanbe; Y Okugi; Y Miyachi

  EUROPEAN JOURNAL OF DERMATOLOGY, Apr. 1996, Peer-reviewed

  

Misc.

• Cryopyrin-associated periodic syndromes (CAPS).

  高田紗奈美; 神戸直智; 神戸直智

  月刊皮膚科, 2024

  
• 診断に難渋した毛包向性菌状息肉症の1例

  内藤 惇; 中溝 聡; 中島 沙恵子; 入江 浩之; 神戸 直智; 椛島 健治; 近藤 摂子

  皮膚の科学, Dec. 2023

  
• 真皮内母斑を伴った背部悪性黒色腫の1例

  東山 礼一; 外川 八英; 末廣 敬祐; 丸 裕吾; 鎌田 憲明; 神戸 直智; 松江 弘之

  Skin Cancer, Oct. 2016

  
• 【免疫症候群(第2版)-その他の免疫疾患を含めて-】原発性免疫不全症候群 自己炎症性疾患 インフラマソームに関連しない状態 化膿性無菌性関節炎・壊疽性膿皮症・アクネ(PAPA)症候群

  高田 紗奈美; 神戸 直智

  日本臨床, Mar. 2016

  
• Blau症候群

  高田 紗奈美; 神戸 直智

  日本小児皮膚科学会雑誌, Mar. 2016

  
• 【メタボリックシンドロームとアレルギー】肥満と自然炎症

  中川 誠太郎; 神戸 直智

  皮膚アレルギーフロンティア, Mar. 2015

  
• 【関節痛と皮膚疾患】臨床例 メトトレキサート関連リンパ増殖性疾患

  若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之; 神戸 美千代; 太田 聡

  皮膚病診療, Feb. 2015

  
• 飼い猫からの感染が考えられたArthroderma vanbreuseghemiiによる体部白癬の1例

  若林 正一郎; 岩澤 真理; 鎌田 憲明; 外川 八英; 神戸 直智; 松江 弘之; 矢口 貴志

  日本皮膚科学会雑誌, Feb. 2015

  
• 【皮膚における炎症性疾患】炎症を伴う皮膚疾患の病態解明最前線 自己炎症症候群

  中川 誠太郎; 松岡 悠美; 神戸 直智

  別冊Bio Clinica: 慢性炎症と疾患, Nov. 2014

  
• アレルギーをめぐるトレンド インフラマソーム

  高田 紗奈美; 神戸 直智

  皮膚アレルギーフロンティア, Nov. 2014

  
• サラゾスルファピリジンによって誘発された天疱瘡の1例

  吉岡 未里; 中川 誠太郎; 高田 紗奈美; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Sep. 2014

  
• 組織学的に真皮に母斑細胞を思わせる胞巣を認めた足底悪性黒色腫の1例

  山本 洋輔; 外川 八英; 末廣 敬祐; 鎌田 憲明; 神戸 直智; 斎田 俊明; 松江 弘之

  臨床皮膚科, Jul. 2014

  
• 再診時の残錠数に着目した第2世代抗ヒスタミン薬の有効性評価

  若林 正一郎; 神戸 直智; 高田 紗奈美; 中川 誠太郎; 林 郁伶; 丸 裕吾; 中野 倫代; 外川 八英; 鎌田 憲明; 松江 弘之

  Progress in Medicine, Jun. 2014

  
• Aneurysmal fibrous histiocytomaの1例

  佐藤 麻有子; 若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之

  臨床皮膚科, May 2014

  
• インフラマソーム(<シリーズ>アレルギー用語解説)

  高田 紗奈美; 神戸 直智

  アレルギー, 2014

  
• 表皮嚢腫を合併し妊娠中に増大し悪性黒色腫が疑われた母斑細胞母斑の1例

  大津 玉緒; 稲福 和宏; 外川 八英; 小俣 渡; 末廣 敬祐; 岩澤 真理; 鎌田 憲明; 神戸 直智; 松江 弘之

  皮膚科の臨床, Dec. 2013

  
• Two considered cases of lupus erythematosus tumidus with systemic involvement

  大田 玲奈; 外川 八英; 中込 大樹; 鎌田 憲明; 神戸 直智; 松江 弘之

  臨床皮膚科, 01 Nov. 2013

  
• 全身症状を伴うlupus erythematosus tumidusと考えた2例

  大田 玲奈; 外川 八英; 中込 大樹; 鎌田 憲明; 神戸 直智; 松江 弘之

  臨床皮膚科, Nov. 2013

  
• 【皮膚真菌症(7)】<臨床例>スリランカ人小児に生じたMicrosporum gypseumによるケルスス禿瘡

  秋田 文; 岩澤 真理; 外川 八英; 神戸 直智; 西村 和子; 松江 弘之

  皮膚病診療, Nov. 2013

  
• エタネルセプト、メトトレキサート投与中に敗血症性ショックをきたした丹毒の1例

  若林 正一郎; 中野 倫代; 中川 誠太郎; 丸 裕吾; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之

  皮膚科の臨床, Oct. 2013

  
• 転倒による手の外傷を契機に発症した続発性皮膚クリプトコッカス症の1例

  山本 洋輔; 外川 八英; 岩澤 真理; 鎌田 憲明; 神戸 直智; 渡邊 正治; 渡辺 哲; 亀井 克彦; 松江 弘之

  臨床皮膚科, Aug. 2013

  
• 免疫グロブリン大量療法を施行し視力障害の改善を認めたChurg-Strauss症候群の1例

  高田 紗奈美; 外川 八英; 田島 綾子; 鎌田 憲明; 神戸 直智; 松江 弘之; 牧田 荘平; 細川 淳一; 池田 啓

  臨床皮膚科, Jul. 2013

  
• Nocardia brasiliensisによる皮膚ノカルジア症の3例

  若林 正一郎; 岩澤 真理; 外川 八英; 宮川 健彦; 鎌田 憲明; 神戸 直智; 松江 弘之; 矢口 貴志; 三上 襄

  臨床皮膚科, Apr. 2013

  
• A Case of Anaphylactic Shock Due to Impurities in a Generic Drug

  Tanizaki Hideaki; Kambe Naotomo; Taki Reiko; Matsumura Yumi; Kore-eda Tetsu; Toichi Eiko; Miyachi Yoshiki

  The Japanese Journal of Dermatology, 2007

  
• 成人肥満細胞症の1例 1995年以降の本邦報告例36例についての臨床統計を含めて

  江川 裕美; 神戸 直智; 谷岡 未樹; 松村 由美; 是枝 哲; 宮地 良樹

  臨床皮膚科, Jan. 2007

  
• Skindex29日本語版を用いた顔面に皮疹を有するアトピー性皮膚炎患者のQOL評価（第1報）タクロリムス含有軟膏の使用によるQOLの変化

  神戸直智; 金澤伸雄; 鈴鴨よしみ; 福原俊一; 宮地良樹

  皮膚の科学, 2004, Peer-reviewed

  
• 【皮膚アレルギー炎症】結合織型ヒト培養肥満細胞からのヒスタミン遊離に及ぼすフマル酸エメダスチンの効果

  神戸 直智; 宮地 良樹

  アレルギー・免疫, Jul. 2002

  
• A picture of atopic dermatitis is worth a thousand words.

  Naotomo Kambe; Kenji Kabashima

  Allergology international : official journal of the Japanese Society of Allergology, Jan. 2022, Peer-reviewed, Invited, Lead author, Corresponding author

  
• ブラウ症候群

  若林 正一郎; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Apr. 2015

  
• 【内科医のための皮疹の診かたのロジック】 内科疾患と皮疹 自己炎症症候群と皮疹

  若林 正一郎; 神戸 直智

  Medicina, May 2014

  
• 若年発症サルコイドーシス/Blau症候群

  若林 正一郎; 神戸 直智

  日本皮膚科学会雑誌, Apr. 2014

  
• ランゲルハンス細胞組織球症の1例

  佐藤 麻有子; 若林 正一郎; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Mar. 2014

  
• 非血縁臍帯血移植後に生じた汗孔角化症の1例

  佐藤 麻有子; 若林 正一郎; 神戸 直智; 松江 弘之; 角田 治美

  日本皮膚科学会雑誌, May 2013

  
• 【アミロイドーシス(2)】 <臨床例>皮膚限局性結節性アミロイドーシス

  林 郁伶; 若林 正一郎; 神戸 直智; 松江 弘之

  皮膚病診療, Apr. 2013

  
• Hypertrophic lichen planusの1例

  高田 紗奈美; 若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之

  角化症研究会記録集, Mar. 2013

  
• 皮膚限局性結節性アミロイドーシスの1例

  林 郁伶; 若林 正一郎; 中野 倫代; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Nov. 2012

  
• ステロイド投与中に生じたExophiala oligospermaによる黒色菌糸症の1例

  若林 正一郎; 岩澤 真理; 丸 裕吾; 神戸 直智; 松江 弘之; 矢口 貴志

  日本皮膚科学会雑誌, Nov. 2012

  
• 汎発性色素性扁平苔癬に続発した有棘細胞癌の1例

  丸 裕; 末廣 敬祐; 若林 正一郎; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Oct. 2012

  
• Helicobacter cinaediによる再発性蜂窩織炎の1例

  林 郁伶; 若林 正一郎; 中野 倫代; 末廣 敬祐; 神戸 直智; 松江 弘之; 若林 華恵; 渡邊 正治; 依田 清江

  臨床皮膚科, Sep. 2012

  
• Helicobacter cinaediによる再発性蜂窩織炎の1例

  林 郁伶; 中野 倫代; 末廣 敬祐; 神戸 直智; 松江 弘之; 若林 正一郎

  日本皮膚科学会雑誌, Mar. 2012

  
• 右上肢のCTCLに対して施行した放射線治療後に生じたStewart-Treves症候群の1例

  若林 正一郎; 末廣 敬祐; 秋田 文; 中野 倫代; 鎌田 憲明; 神戸 直智; 松江 弘之; 秋田 新介

  日本皮膚科学会雑誌, May 2011

  
• Monoclonal gammopathy of undetermined significance(MGUS)に合併したクリオグロブリン血症の1例

  八木 洋輔; 谷岡 未樹; 神戸 直智; 松村 由美; 是枝 哲; 宇谷 厚志; 宮地 良樹; 加藤 真弓

  皮膚の科学, Apr. 2007

  
• アムロジンによる湿疹型薬疹1例

  峯垣 裕介; 谷岡 未樹; 松村 由美; 是枝 哲; 神戸 直智; 松吉 徳久; 宮地 良樹

  皮膚の科学, Feb. 2007

  
• 成人性肥満細胞症の1例

  江川 裕美; 神戸 直智; 谷岡 未樹; 松村 由美; 是枝 哲; 宮地 良樹

  皮膚の科学, Aug. 2006

  
• ジェネリック医薬品に含まれる有効成分以外の副成分を原因とするアナフィラキシーショックの1例

  谷崎 英昭; 瀧 玲子; 神戸 直智; 松村 由美; 是枝 哲; 宮地 良樹; 十一 英子

  日本皮膚アレルギー学会総会・日本接触皮膚炎学会総会合同学術大会プログラム・抄録集, Jul. 2006

  
• Castleman's diseaseの1例

  瀧 玲子; 谷岡 未樹; 松村 由美; 是枝 哲; 神戸 直智; 松吉 徳久; 宮地 良樹

  皮膚の科学, Jun. 2006

  
• 肺病変を伴った膿疱型壊疽性膿皮症の1例

  中川 雄仁; 荒木 絵里; 猪口 奈緒子; 松村 由美; 神戸 直智; 是枝 哲; 宮地 良樹

  日本皮膚科学会雑誌, Mar. 2005

  
• 肥満細胞はOX40リガンドの発現を介して同種骨髄移植後の慢性GVHDに関与する

  神戸 直智; 松村 由美; 宮地 良樹

  日本研究皮膚科学会年次学術大会・総会プログラム, Apr. 2004

  
• 最近経験した先天性表皮水疱症の2例

  木村 亜矢子; 神戸 直智; 松江 弘之; 夏賀 健; 清水 宏

  日本皮膚科学会雑誌, Feb. 2012

  
• 低用量メトトレキサートパルス療法を導入した若年発症皮膚型結節性多発動脈炎の1例

  冨板 美奈子; 有馬 孝恭; 森田 慶紀; 中野 泰至; 下条 直樹; 河野 陽一; 神戸 直智; 及川 真喜子; 中村 悠美; 松江 弘之

  日本小児皮膚科学会雑誌, Nov. 2009

  
• エタネルセプト投与中に全身に多発する膿疱疹を来した関節リウマチの一例

  平松 有希子; 池田 啓; 横田 雅也; 高橋 健太郎; 須藤 明; 加々美 新一郎; 廣瀬 晃一; 渡邊 紀彦; 佐藤 貴史; 神戸 直智; 松江 弘之; 中島 裕史

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2009

  
• エレンタールPを長期使用中の患児に生じた爪の白色変化

  佐藤 麻有子; 東山 礼一; 神戸 直智; 村山 圭; 市本 景子; 松江 弘之

  日本皮膚科学会雑誌, Sep. 2013

  
• 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 PRO(patient reported outcome)の検討とICT(information and technology)化に関する研究

  平野亨; 森雅亮; 山路健; 吉藤元; 宮前多佳子; 西小森隆太; 井澤和司; 岸田大; 井上祐三朗; 住友秀次; 楢崎秀彦; 神戸直智; 横川直人; 横川直人; 井上満代; 向井知之; 川邊智宏; 盛一享徳

  難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和2年度 総括・分担研究報告書(Web), 2021

  
• ブラウ症候群の臨床像と診断のポイント

  神戸 直智

  小児科, Sep. 2016

  
• 皮膚所見から考える自己炎症症候群 (第112回日本皮膚科学会総会 いま望まれる皮膚科心療) -- (教育講演 皮膚から診断する全身疾患)

  神戸 直智

  日本皮膚科学会雑誌 = The Japanese journal of dermatology, Dec. 2013

  
• 序 : 自己炎症症候群の概説と現在提唱されている定義・分類 (特集 自己炎症症候群 : 稀な遺伝性疾患からリウマチ・アレルギー疾患へのメッセージ)

  江原 瑞枝; 神戸 直智

  アレルギー・免疫, Oct. 2013

  
• 皮膚疾患のQOL

  神戸 直智

  日本皮膚科学会雑誌 = THE JAPANESE JOURNAL OF DERMATOLOGY, 20 Mar. 2004

  
• 線維芽細胞とマスト細胞 (特集:今,なぜマスト細胞なのか?-1-)

  神戸 直智; 黒沢 元博; 宮地 良樹

  アレルギ-の領域, Sep. 1997

  
• Dermatomyositis with generalized severe edema

  大野 綾子; 中村 悠美; 神戸 直智

  皮膚科の臨床, May 2009

  
• IL-1β Secretion Through Inflammasome and Histamine-independent Urticaria

  KAMBE Naotomo; SATOH Takashi

  Journal of environmental dermatology and cutaneous allergology, 31 Oct. 2010

  
• 慢性蕁麻疹 (特集 アレルギー・免疫疾患の治癒を考える)

  中村 悠美; 神戸 直智; 松江 弘之

  アレルギ-・免疫, Sep. 2007

  
• A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and basal cell carcinoma on the region susceptible to mechanical stimuli

  玉城 裕妃子; 神戸 直智; 藤澤 章弘

  臨床皮膚科, Mar. 2008

  
• ヒト肥満細胞の増殖に対するトシル酸スプラタストの効果

  神戸 直智; 宮地 良樹

  西日本皮膚科 = The Nishinihon journal of dermatology, 01 Aug. 2002

  
• Effect of anti-allergic drugs on histamine release from mast cells : Analysis with cord blood-derived human cultured mast cells

  KANBE Naotomo; KUROSAWA Motohiro; IGARASHI Yasushi; AMANO Hiroo; MATSUSHIMA Youichiro; MIYACHI Yoshiki

  炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation, 31 Mar. 1999

  
• A case of intravascular large B-cell lymphoma accompanied with generalized telangiectasia

  小西 朝子; 神戸 直智; 松村 由美

  臨床皮膚科, Dec. 2002

  
• Antibody therapy against autoinflammatory diseases

  佐藤 貴史; 神戸 直智

  医学のあゆみ, 06 Aug. 2011

  
• 抗ヒスタミン薬の投与法を語る

  椛島 健治; 神戸 直智; 杉浦 一充; 室田 浩之

  皮膚アレルギーフロンティア, Mar. 2011

  
• Case reports: Phylloid hypomelanosis accompanied with mosaic partial trisomy 13

  木村 亜矢子; 神戸 直智; 外川 八英

  皮膚科の臨床, Mar. 2011

  
• Case reports: Successful treatment with topical corticosteroid and cryotherapy on multiple satellites of granuloma telangiectaticum

  佐藤 貴史; 神戸 直智; 中村 悠美

  皮膚科の臨床, Mar. 2011

  
• A case of the verrucous type of sporotrichosis on the forehead and the effect of potasium iodide

  小野 泰伸; 岩澤 真理; 神戸 直智

  臨床皮膚科, Nov. 2010

  
• A case of plaque type cutaneous sarcoidosis accompanied with multiple molluscum contagiosa

  木村 亜矢子; 神戸 直智; 外川 八英

  臨床皮膚科, Jun. 2010

  
• Filaggrin and atopic dermatitis

  中川 誠太郎; 神戸 直智

  臨床免疫・アレルギー科, Sep. 2012

  
• CASE REPORTS : Intravascular Large B-Cell Lymphoma Diagnosed by Random Skin Biopsy

  及川 真喜子; 神戸 直智; 川口 岳晴

  皮膚科の臨床, Jul. 2012

  
• Autoinflammatorry diseases

  中村 悠美; 神戸 直智

  臨床皮膚科, Apr. 2014

  
• CASE REPORTS : Primary Cutaneous Adenoid Cystic Carcinoma Accompanied with Perineural Invasion

  木村 亜矢子; 神戸 直智; 末廣 敬祐

  皮膚科の臨床, Jan. 2012

  
• CCL2 serves as a downstream effector of interleukin-1β and tumour necrosis factor-α signalling in Schnitzler syndrome.

  KAMBE NAOTOMO

  British Journal of Dermatology, Apr. 2019, Peer-reviewed

  
• 【疾患別・知っておきたい 皮膚科の検査とその評価法】 自己炎症症候群(Schnitzler症候群、クリオピリン関連周期熱症候群)

  神戸 直智; 西小森 隆太

  皮膚科の臨床, May 2017

  
• 肥満細胞の研究を通じて

  神戸 直智; 中畑 龍俊; 北村 幸彦

  皮膚アレルギーフロンティア, Jul. 2016

  
• Role for mast cells in Schnitzler's syndrome: here mast cells master a rash, too

  N. Kambe

  BRITISH JOURNAL OF DERMATOLOGY, Aug. 2015, Peer-reviewed

  
• 自己炎症性疾患の治療標的分子の同定および薬剤開発基盤の整備 ブラウ症候群患者由来疾患特異的iPS細胞の樹立と病態解析の試み

  神戸直智; 松江弘之; 中野倫代; 江原瑞枝; 高田紗奈美; 中畑龍俊; 斎藤潤

  自己炎症性疾患の治療標的分子の同定および薬剤開発基盤の整備 平成26年度 委託業務成果研究報告書, 2015

  
• Detailed Anatomical Distribution of Synovial Inflammation Revealed By Ultrasound in Patients with Blau Syndrome.

  Kei Ikeda; Naotomo Kambe; Syuji Takei; Taiji Nakano; Yuzaburo Inoue; Minako Tomiita; Natsuko Oyake; Takashi Satoh; Tsuyoshi Yamatou; Tomohiro Kubota; Ikuo Okafuji; Nobuo Kanazawa; Ryuta Nishikomori; Naoki Shimojo; Hiroyuki Matsue; Hiroshi Nakajima

  ARTHRITIS & RHEUMATOLOGY, Oct. 2014, Peer-reviewed

  
• ミノサイクリンが著効したsuperficial granulomatous pyodermaの1例

  外川 八英; 山本 洋輔; 鎌田 憲明; 神戸 直智; 松江 弘之; 及川 真喜子

  西日本皮膚科, Jun. 2014

  
• 頻回の二重濾過血漿交換療法(DFPP)を施行するも難治性の水疱性類天疱瘡の1例

  山本 洋輔; 若林 正一郎; 鎌田 憲明; 神戸 直智; 松江 弘之

  西日本皮膚科, Jun. 2014

  
• センチネルリンパ節生検を施行した悪性黒色腫70例におけるセンチネルリンパ節生検の意義

  末廣 敬祐; 山本 洋輔; 塚本 利朗; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Apr. 2014

  
• 過去3年半に施行した悪性黒色腫術後DAVFeron療法およびDFeron療法における副作用発現の比較

  山本 洋輔; 末廣 敬祐; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Apr. 2014

  
• 関節リウマチの治療中に生じたメトトレキサート関連リンパ増殖性疾患の1例

  若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Mar. 2014

  
• Brunsting-Perry型を思わせる皮疹の分布を初発症状とした類天疱瘡の1例

  山本 洋輔; 外川 八英; 神戸 直智; 松江 弘之; 橋本 隆

  日本皮膚科学会雑誌, Mar. 2014

  
• 若年発症サルコイドーシス/Blau症候群 (特集 自己炎症症候群の診断と治療)

  中野 倫代; 神戸 直智

  分子リウマチ治療, Feb. 2014

  
• 真皮に母斑細胞を思わせる胞巣を認めた足底悪性黒色腫の1例

  山本 洋輔; 末廣 敬祐; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之; 斎田 俊明

  日本皮膚科学会雑誌, Feb. 2014

  
• Quantitative Image Analysis Of Articular Involvement In Blau Syndrome By Radiographic Calpal Length and Ultrasound Assessment

  Tsuyoshi Yamatou; Tomohiro Kubota; Harumi Akaike; Yuichi Yamasaki; Yukiko Nonaka; Yasuhito Nerome; Tomoko Takezaki; Hiroyuki Imanaka; Kei Ikeda; Naotomo Kambe; Syuji Takei; Tomokazu Nagakura

  ARTHRITIS AND RHEUMATISM, Oct. 2013

  
• 千葉茨城県境より受診した皮膚悪性腫瘍の進行例

  山本 洋輔; 末廣 敬祐; 丸 裕吾; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Jul. 2013

  
• Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation

  T. Satoh; N. Kambe; H. Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2013

  
• A Case of Multiple Fixed Drug Eruption Due to not Only Turmeric but Also Mefenamic Acid

  TAKADA Sanami; TOGAWA Yaei; WAKABAYASHI Seiichiro; TAJIMA Ayako; NAKANO Michiyo; KAMADA Noriaki; KAMBE Naotomo; MATSUE Hiroyuki

  Journal of environmental dermatology and cutaneous allergology, 30 Apr. 2013

  
• 強皮症患者の血清マイクロRNAの発現とその役割

  田中 繁; 須藤 明; 池田 啓; 眞山 快枝; 中込 大樹; 岩本 太郎; 鈴木 浩太郎; 神戸 直智; 松江 弘之; 松村 竜太郎; 柏熊 大輔; 岩本 逸夫; 中島 裕史

  アレルギー, Apr. 2013

  
• 【ざ瘡・ざ瘡様発疹】 <臨床例>悪性梅毒

  中川 誠太郎; 神戸 直智; 若林 正一郎; 山本 洋輔; 宮川 健彦

  皮膚病診療, Mar. 2013

  
• [The present and the prospect of study on Blau syndrome/early-onset sarcoidosis].

  Nakano M; Kambe N

  Nihon rinsho. Japanese journal of clinical medicine, 2013, Peer-reviewed

  
• A case of Noonan syndrome-like disorder with loose anagen hair

  中川 誠太郎; 神戸 直智; 羽田 明

  臨床皮膚科, Dec. 2012

  
• Mast cell activation through NLRP3 inflammasome

  神戸 直智; 中村 悠美

  臨床免疫・アレルギー科, Nov. 2012

  
• 当施設において過去2年間に施行した悪性黒色腫術後DAVFeron療法における副作用調査

  山本 洋輔; 末廣 敬祐; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Nov. 2012

  
• Skin and granulomatous disease evoked by autoinflammatory mechanism

  中野 倫代; 神戸 直智

  医学のあゆみ, 08 Sep. 2012

  
• Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation

  T. Satoh; K. Naotomo; H. Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012

  
• Ultrapure soft water improves the skin barrier function of child atopic dermatitis: the first report

  Y. Togawa; N. Kambe; N. Shimojo; H. Mochizuki; H. Matsuda; A. Tanaka; H. Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012

  
• Critical Role for Mast Cells in IL-1 beta-Driven Skin Inflammation Accompanying a Disease-Associated Nlrp3 Mutation

  Y. Nakamura; L. Franchi; N. Kambe; G. Meng; W. Strober; G. Nunez

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012

  
• 外傷を契機に発症した続発性皮膚クリプトコッカス症の1例

  山本 洋輔; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之; 渡邊 正治; 渡辺 哲; 亀井 克彦

  日本皮膚科学会雑誌, Aug. 2012

  
• 過去2年間に当施設で経験したエクリン汗孔癌9例のまとめ

  山本 洋輔; 末廣 敬祐; 鎌田 憲明; 神戸 直智; 松江 弘之

  日本皮膚科学会雑誌, Apr. 2012

  
• Peripheral CD14+monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling

  Naotomo Kambe; Takashi Satoh; Hiroyuki Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2011

  
• Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing

  Takashi Satoh; Naotomo Kambe; Hiroyuki Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2011

  
• 【インフラマソーム】 インフラマソームの自発的活性化を病態とする自己炎症症候群

  神戸 直智; 佐藤 貴史; 西小森 隆太

  生体の科学, Jun. 2011

  
• autoinflammatory disorders NLRP3体細胞モザイクはCINCA症候群の25%以上に認められる

  田中 尚子; 井澤 和司; 西小森 隆太; 神戸 直智; 河合 朋樹; 酒井 秀政; 八角 高裕; 平家 俊男

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Jun. 2011

  
• Early-onset sarcoidosis/Blau syndrome

  Naotomo Kambe; Takashi Satoh; Michiyo Nakano; Yuumi Nakamura; Hiroyuki Matsue

  Japanese Journal of Clinical Immunology, 2011, Peer-reviewed

  
• NLRP3体細胞モザイクはChronic infantile neurological cutaneous and articular(CINCA)症候群の約25％に認められる

  田中尚子; 井澤和司; 斎藤潤; 作間未織; 大嶋宏一; 小原収; 西小森隆太; 森本剛; 神戸直智; 中畑龍俊; 阿部純也; 酒井秀政; 村田祐樹; 河合朋樹; 八角高裕; 平家俊男

  厚生労働省難治性疾患克服研究事業 原発性免疫不全症候群に関する調査研究班班会議, Jan. 2011

  
• Enhanced NF-kappa B activation with NLRP3 activator correlates with disease activities in cryopyrin-associated periodic syndrome

  Takashi Satoh; Naotomo Kambe; Hiroyuki Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2010

  
• 【「分子標的薬」時代へ 投与のコツと副反応のコントロール】 新しい分子標的薬のトピックス IL-1をターゲットとした炎症性皮膚疾患の治療

  神戸 直智; 西小森 隆太

  Visual Dermatology, Jul. 2010

  
• The 1st JSID Kisaragi Juku: The junior tutors' perspective.

  Kenji Kabashima; Riichiro Abe; Satoshi Hirakawa; Naotomo Kambe; Manabu Ohyama; Manabu Fujimoto

  Journal of dermatological science, Jun. 2010, Peer-reviewed

  
• Long-term ICAM-1 and transient PDGF-B expression on PMA-activated THP-1 cells harboring early-onset sarcoidosis/Blau syndrome-associated NOD2 mutations

  N. Kanazawa; M. Nishiyama; H. Li; I. Okafuji; N. Kambe; E. Furukawa

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2010

  
• 【子どもの皮膚疾患の診かた】 小児皮膚疾患 色素失調症

  西小森 隆太; 河合 朋樹; 内尾 寛子; 神戸 直智; 松村 由美

  小児科, Apr. 2010

  
• KIT Masters Mast Cells in Kids, Too

  Naotomo Kambe; B. Jack Longley; Yoshiki Miyachi; Kenji Kabashima

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 2010, Peer-reviewed

  
• Re: The authors respond

  Naotomo Kambe; Yuumi Nakamura

  Allergology International, 2010, Peer-reviewed

  
• Cryoglobinaemia type I: serum cryoprecipitate formation at 25 degrees C (vol 33, pg 361, 2008)

  Y. Yagi; M. Tanioka; N. Kambe

  CLINICAL AND EXPERIMENTAL DERMATOLOGY, Oct. 2009

  
• Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria (vol 206, pg 1037, 2009)

  Yuumi Nakamura; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Yun-Gi Kim; Makoto Murakami; Gabriel Nunez; Hiroyuki Matsue

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2009

  
• 自然寛解した父親の病因遺伝子変異を引き継ぎ皮疹を発症した若年発症サルコイドーシスの1例

  佐藤 貴史; 中村 悠美; 神戸 直智; 松江 弘之; 西小森 隆太

  日本皮膚科学会雑誌, Feb. 2009

  
• Pathophysiological analysis of cryopyrin-associated periodic syndrome

  Kambe N; Nakamura Y; Matsue H

  Chiba Medical Journal, 2009, Peer-reviewed

  
• A case of idiopathic thrombocytopenic purpura suggesting an initial manifestation of systemic lupus erythematosus

  Ayako Shimizu; Naotomo Kambe; Yaei Togawa; Noriaki Kamada; Kentarou Ohki; Minako Tomiita; Hiroyuki Matsue

  ARCHIVES OF DERMATOLOGICAL RESEARCH, Jan. 2009

  
• 【小児疾患診療のための病態生理】 リウマチ性疾患とその周辺疾患 自己炎症症候群

  西小森 隆太; 斎藤 潤; 岡藤 郁夫; 神戸 直智

  小児内科, Nov. 2008

  
• 免疫疾患の分子基盤最前線 "CIAS1遺伝子変異陰性"CINCA症候群における潜在性CIAS1遺伝子モザイシズムについて

  西小森 隆太; 斎藤 潤; 神戸 直智; 藤澤 章弘; 谷崎 英昭; 中村 悠美; 河合 朋樹; 八角 高裕; 村田 祐樹; 谷風 尚子; 酒井 秀政; 田中 孝之; 平家 俊男; 宮地 良樹; 中畑 龍俊

  日本臨床免疫学会会誌, Aug. 2008

  
• Cryopyrin-associated IL-1 beta secretion in mast cells and a role played by mast cells in auto-inflammatory disorders

  Y. Nakamura; N. Kambe; H. Matsue

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2008

  
• Direct development of primate connective tissue-type mast cells from immature state of CD34+hemangioblastic progenitors, independently from the development pathway of mucosal-type mast cells

  N. Kambe; F. Ma; T. Nakahata

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2008

  
• A case of early-onset sarcoidosis which showed spontaneous regression of his clinical manifestations but inherited skin eruption to his baby: what should we call this systemic inflammatory granulomatosis associated with NOD2 mutation?

  N. Kambe; Y. Nakamura; Okafuji, I; R. Nishikomori; N. Kanazawa; H. Matsue

  CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Mar. 2008

  
• Nationwide surveillance of chronic infantile neurological cutaneous and articular syndrome in Japan

  M. Saito; R. Nishikomori; N. Kambe; H. Sakai; T. Kawai; A. Kitano; Y. Takaoka; T. Heike; H. Kanegane; T. Nakahata

  CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Mar. 2008

  
• 【Autoinflammatory syndromes】 CINCA症候群の分子病態 CIAS1変異陰性CINCA症候群におけるCIAS1モザイシズム

  西小森 隆太; 神戸 直智; 斎藤 潤; 藤澤 章弘

  炎症と免疫, Feb. 2008

  
• "CIAS1遺伝子変異陰性"CINCA症候群における潜在性CIAS1遺伝子モザイシズムについて

  西小森 隆太; 谷風 尚子; 酒井 秀政; 田中 孝之; 平家 俊男; 宮地 良樹; 中畑 龍俊; 斎藤 潤; 神戸 直智; 藤澤 章弘; 谷崎 英昭; 中村 悠美; 河合 朋樹; 八角 高裕; 村田 祐樹

  日本臨床免疫学会総会抄録集, 2008

  
• 結節性多発動脈炎の1女児例

  栃木透; 鶴岡智子; 小川真司; 井上祐三朗; 有馬孝恭; 冨板美奈子; 下条直樹; 河野陽一; 神戸直智; 松本弘

  日本小児科学会雑誌, Nov. 2007

  
• 【蕁麻疹の分類と臨床 アップデート】 遺伝性蕁麻疹の病態と原因遺伝子

  神戸 直智; 中村 悠美; 斎藤 潤; 西小森 隆太

  アレルギー・免疫, Oct. 2007

  
• 本邦におけるブラウ症候群および若年性サルコイドーシス20例の臨床像

  岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 神戸 直智; 斎藤 潤; 藤澤 章弘; 谷崎 英昭; 平家 俊男; 宮地 良樹; 中畑 龍俊

  日本臨床免疫学会会誌, Aug. 2007

  
• A Family Case of Cryopyrin-associated Periodic Syndrome

  Fujisawa Akihiro; Kambe Naotomo; Saito Megumu; Nishikomori Ryuta; Heike Toshio; Miyachi Yoshiki

  The Japanese Journal of Dermatology, Aug. 2007

  
• 若年発症サルコイドーシスの臨床像とNOD2遺伝子変異の相関

  金澤 伸雄; 岡藤 郁夫; 谷崎 英昭; 神戸 直智; 西小森 隆太; 中畑 龍俊; 宮地 良樹

  日本臨床分子医学会学術総会プログラム・抄録集, Jul. 2007

  
• ヒトES細胞から肥満細胞への分化誘導

  馬 峰; 辻 浩一郎; 神戸 直智; 海老原 康博; 中内 啓光; 中畑 龍俊

  Inflammation and Regeneration, Jul. 2007

  
• Cryopyrinの疾患関連変異は単球系細胞にカテプシンB依存性細胞死を誘導する

  斎藤 潤; 神戸 直智; 平家 俊男; 中畑 龍俊; 宮地 良樹

  Inflammation and Regeneration, Jul. 2007

  
• Muckle-Wells症候群の1家系

  藤澤 章弘; 神戸 直智; 宮地 良樹; 斎藤 潤; 西小森 隆太

  西日本皮膚科, Jun. 2007

  
• 【最近のトピックス2007 Clinical Dermatology 2007】 最近話題の皮膚疾患 自己炎症性疾患 特徴的な皮膚症状を伴う遺伝性周期熱症候群

  谷崎 英昭; 神戸 直智; 西小森 隆太; 金澤 伸雄

  臨床皮膚科, Apr. 2007

  
• Autoinflammatory syndromeの新たなる展開 CINCA症候群におけるCIAS1モザイシズムについて

  西小森 隆太; 斉藤 潤; 藤澤 章弘; 神戸 直智; 河合 朋樹; 岡藤 郁夫; 平家 俊男; 宮地 良樹; 中畑 龍俊

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2007

  
• クライオピリン関連周期熱症候群の本邦11例における臨床像と遺伝子解析のまとめ

  藤澤 章弘; 神戸 直智; 谷崎 英昭; 齋藤 潤; 西小森 隆太; 宮地 良樹

  日本皮膚科学会雑誌, Mar. 2007

  
• 若年発症サルコイドーシス本邦17例における臨床像と遺伝子解析のまとめ

  谷崎 英昭; 神戸 直智; 岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 宮地 良樹

  日本皮膚科学会雑誌, Mar. 2007

  
• A successful add-on therapy of hypereosinophilic syndrome with suplatast tosilate

  Matsumura Y; Kambe N; Nishigori C; Miyachi Y

  Skin Research, 2007, Peer-reviewed

  
• Assessment of the therapeutic effect of bepotastine besilate on chronic urticaria using a visual analogue scale (VAS)

  Dainichi T; Furue M; Murota H; Katayama I; Kambe N; Miyachi Y; Imafuku S; Terao H

  Skin Research, 2007, Peer-reviewed

  
• Familial Mediterranean fever: MEFV gene mutations and treatment

  Megumu Saito; Ryuta Nishikomori; Naotomo Kambe

  Japanese Journal of Clinical Immunology, 2007, Peer-reviewed

  
• Necrolytic migratory erythema with hyperglucagonemia and zinc deficiency

  Nakahigashi K; Tanioka M; Kambe N; Utani A; Miyachi Y

  Skin Research, 2007, Peer-reviewed

  
• ウイルス感染と宿主応答・宿主側の要因 CIAS1の活性化あるいは疾患関連変異体によって誘導される細胞死はカテプシンB依存性の急速なネクローシス様細胞死である

  藤澤 章弘; 神戸 直智; 齋藤 潤; 西小森 隆太

  日本免疫学会総会・学術集会記録, Nov. 2006

  
• CIAS 1体細胞モザイクによって発症したCINCA症候群に対するanakinraの治療効果

  神戸 直智; 藤澤 章弘; 西小森 隆太; 齋藤 潤; 中畑 龍俊; 宮地 良樹

  日本小児皮膚科学会雑誌, Nov. 2006

  
• CINCA(chronic infantile neurological cutaneous and articular)症候群

  斎藤 潤; 西小森 隆太; 神戸 直智

  リウマチ科, Nov. 2006

  
• Mutational analysis in neonatal-onset multisystem inflammatory disease: Comment on the articles by Frenkel et al and Saito et al - Reply

  Megumu Saito; Akihiro Fujisawa; Ryuta Nishikomori; Naotomo Kambe; Yoshiki Miyachi; Toshio Heike; Tatsutoshi Nakahata

  ARTHRITIS AND RHEUMATISM, Aug. 2006, Peer-reviewed

  
• Reply [3]

  Megumu Saito; Akihiro Fujisawa; Ryuta Nishikomori; Naotomo Kambe; Yoshiki Miyachi; Toshio Heike; Tatsutoshi Nakahata

  Arthritis and Rheumatism, Aug. 2006

  
• CINCA症候群の男児例

  斎藤 潤; 西小森 隆太; 日詰 真美; 岡藤 郁夫; 吉岡 孝和; 八角 高裕; 楠 隆; 平家 俊男; 中畑 龍俊; 神戸 直智; 藤澤 章弘

  日本小児科学会雑誌, Jun. 2006

  
• Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome

  M Saito; R Nishikomori; A Fujisawa; N Kambe; MN Hizume; Okafuji, I; T Yoshioka; M Yoshimoto; K Omori; T Kusunoki; T Heike; Y Miyachi; T Nakahata

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2006

  
• Development of tryptase and chymase double positive mature mast cells from cynomolgus monkey embryonic stem cells

  N Kambe; F Ma; Y Miyachi; T Nakahata

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2006

  
• 小児科学・医療にブレークスルーをもたらした症例・研究 体細胞モザイクで発症したCINCA症候群の男児

  斎藤 潤; 西小森 隆太; 藤澤 章弘; 神戸 直智; 岡藤 郁夫; 吉岡 孝和; 平家 俊男; 宮地 良樹; 中畑 龍俊

  日本小児科学会雑誌, Feb. 2006

  
• 若年発症サルコイドーシスは,ブラウ症候群と同じく,細胞内細菌成分受容体Nod2の機能獲得性変異に基づく遺伝子疾患である

  金澤 伸雄; 神戸 直智; 宮地 良樹; 岡藤 郁夫; 日詰 真美; 西小森 隆太; 平家 俊男; 中畑 龍俊; 吉村 長久

  日本小児皮膚科学会雑誌, Nov. 2005

  
• CIAS1の体細胞モザイクにより発症したCINCA症候群例

  斎藤 潤; 岡藤 郁夫; 吉岡 孝和; 西小森 隆太; 平家 俊男; 神戸 直智; 楠 隆; 八角 高裕; 片村 憲司; 大森 勝之; 中畑 龍俊

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• Early-onset sarcoidosis is closely related with CARD15 gene mutations causing constitutive nuclear factor-kappa B activation

  N Kanazawa; Okafuji, I; N Kambe; R Nishikomori; T Heike; T Nakahata; Y Miyachi

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2005

  
• c-kit遺伝子異常が検出されたdiffuse cutaneous mastocytosisの一女児例

  平松 英文; 矢野 潤; 宮崎 真紀; 水嶋 康浩; 松原 央; 小林 道弘; 足立 壮一; 中畑 龍俊; 神戸 直智

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005

  
• 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導

  北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005

  
• Generation of mature tryptase/chymase double positive mast cells from a cynomolgus monkey embryonic stem cells

  F Ma; N Kambe; D Wang; G Shinoda; K Umeda; H Suemori; N Nakatsuji; K Tsuji; T Hekei; T Nakahata

  EXPERIMENTAL HEMATOLOGY, Jul. 2005

  
• The Mechanism of Mast Cell Development and Its Pathophysiological Functions

  KAMBE Naotomo; MIYACHI Yoshiki; NAKAHATA Tatsutoshi

  日本小児血液学会雑誌, 30 Jun. 2005

  
• 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導

  北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓

  日本リンパ網内系学会会誌, Jun. 2005

  
• Early‐onset sarcoidosis and NOD2: Summary on genetic analysis of Japanese 10 cases

  神戸直智; 西小森隆太; 金沢伸雄; 岡藤郁夫; 藤沢章弘; 平家俊男; 中畑龍俊; 宮地良樹

  炎症・再生, 25 May 2005

  
• Early-onset sarcoidosis and NOD2 : Summary on genetic analysis of Japanese 10 cases

  KAMBE Naotomo; NISHIKOMORI Ryuta; KANAZAWA Nobuo; OKAFUJI Ikuo; FUJISAWA Akihiro; HEIKE Toshio; NAKAHATA Tatsutoshi; MIYACHI Yoshiki

  Ensho Saisei, 25 May 2005

  
• CINCA症候群の男児例

  齋藤 潤; 西小森 隆太; 日詰 真美; 岡藤 郁夫; 吉岡 孝和; 八角 高裕; 楠 隆; 平家 俊男; 中畑 龍俊; 神戸 直智; 藤澤 章弘

  日本小児科学会京都地方会会報, May 2005

  
• Early-onset sarcoidosis and CARD15 mutations: common genetic etiology with Blau syndrome

  Okafuji, I; R Nishikomori; N Kanazawa; N Kambe; M Nakata-Hizume; T Yoshioka; T Heike; Y Miyachi; T Nakahata

  FASEB JOURNAL, Mar. 2005

  
• 若年性サルコイドーシスとCARD15(NOD2)遺伝子異常との関係 本邦での11例の検討

  岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 神戸 直智; 吉岡 孝和; 齋藤 潤; 楠 隆; 八角 高裕; 片村 憲司; 平家 俊男; 中畑 龍俊

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• ヒト肥満細胞による樹状細胞の活性化とT細胞反応への影響

  北脇 年雄; 杉本 直志; 門脇 則光; 神戸 直智; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• 全身性疾患としてのサルコイドーシスの周辺疾患と鑑別 Blau症候群とサルコイドーシス(Blau syndrome and sarcoidosis)

  金澤 伸雄; 西小森 隆太; 神戸 直智

  サルコイドーシス/肉芽腫性疾患, Oct. 2004

  
• 若年性サルコイドーシス本邦報告8例におけるNod2遺伝子変異の検討

  神戸 直智; 西小森 隆太; 金澤 伸雄; 岡藤 郁夫; 藤澤 章弘; 平家 俊男; 中畑 龍俊; 宮地 良樹

  炎症・再生, Jul. 2004

  
• 【膠原病・アレルギー疾患】 若年性サルコイドーシスの1例 CARD15(NOD2)遺伝子の異常との関係

  西小森 隆太; 金澤 伸雄; 神戸 直智; 錦織 千佳子; 荒川 明子; 岡藤 郁夫; 日詰 真美; 田辺 晶代; 吉岡 孝和; 片村 憲司; 張 璽; 木村 暢佑; 楠 隆; 平家 俊男; 中畑 龍俊

  小児科臨床, Jun. 2004

  
• ヒト肥満細胞の増殖に対するトシル酸スプラタストの効果

  藤澤 章弘; 神戸 直智; 中畑 龍俊; 宮地 良樹

  アレルギー, Mar. 2004

  
• ヒト肥満細胞のマウス生体内での分化・増殖

  神戸 直智; 宮地 良樹; 平松 英文; 中畑 龍俊

  アレルギー科, Mar. 2004

  
• QOL Evaluation of the Atopic Dermatitis Patients who Have Eruption on Their Face by Using Skindex29©Japanese Version (First Report) - QOL improvement after the treatment with the tacrolimus ointment

  Kambe N; Kanazawa N; Miyachi Y; Suzukamo Y; Fukuhara S.-I

  Skin Research, 2004, Peer-reviewed

  
• Treatment of intractable prurigo with roxithromycin: Report of three cases

  Okano H; Okunaka M; Shimada H; Mori R; Ikoma A; Kambe N; Nishimura Y; Matsumura Y; Toichi E; Kore-Eda S; Takahashi K; Tachibana T; Miyachi Y

  Skin Research, 2004, Peer-reviewed

  
• What is the physiological function of mast cells? Commentary 9

  N Kambe; Y Miyachi

  EXPERIMENTAL DERMATOLOGY, Dec. 2003

  
• Development of both human connective tissue type and mucosal type mast cells in mice from hematopoietic stem cells.

  N Kambe; H Hiramatsu; M Ito; T Heike; Y Miyachi; T Nakahata

  BLOOD, Nov. 2003

  
• Development of human mast cells in mice

  神戸直智; 宮地良樹; 平松英文; 中畑龍俊

  月刊アレルギーの臨床, 20 Sep. 2003

  
• Expression of gp34(OX40L) on mast cells in GVHD patients

  A Kotani; T Hori; N Kanbe; Y Matsumura; K Nagai; T Uchiyama

  EXPERIMENTAL HEMATOLOGY, Jul. 2003

  
• Successful Treatment with Octreotide for Intestinal Pseudoobstruction in Two Patients with Systemic Sclerosis

  Sugawara N; Abe M; Tamura A; Ishikawa O; Kambe N

  Skin Research, 2003, Peer-reviewed

  
• Mastocytosis - Pathomechanism and potential treatment focusing on c-kit

  Shimonaka M; Kambe N; Miyachi Y

  Skin Research, 2003, Peer-reviewed

  
• ヒト造血幹細胞から肥満細胞へのin vivo分化モデルの確立

  神戸 直智; 平松 英文; 宮地 良樹; 中畑 龍俊

  アレルギー, Oct. 2002

  
• 結合織型ヒト肥満細胞培養法の確立

  神戸 直智; 宮地 良樹; 中畑 龍俊

  アレルギー, Oct. 2001

  
• Serum-free culture conditions expand human mast cells in vitro

  N Kambe; M Kambe; LB Schwartz

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001

  
• Cord blood-derived cultured human mast cells constitutively express messenger RNA for transforming growth factor beta(1).

  N Kanbe; M Kurosawa; Y Miyachi

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1998

  
• Increased fibroblasts proliferation and type I collagen production under the co-culture with human mast cells.

  M Abe; O Ishikawa; M Kurosawa; Y Igarashi; H Amano; N Kanbe; Y Miyachi

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1997

  
• A Case of Interstitial Pneumonia Possibly Induced by Colchicine

  Kanbe N; Kurosawa M; Takeuchi Y

  Japanese Journal of Chest Diseases, 1996, Peer-reviewed

  
• 180 ヒト培養肥満細胞からのサイトカイン産生 : TGF-βを中心に

  神戸 直智; 安部 正敏; 天野 博雄; 五十嵐 康; 黒沢 元博; 宮地 良樹; 永田 博史; 斉藤 博久; 中畑 龍俊

  アレルギー, 1996

  
• 644 ヒト培養肥満細胞サブタイプに及ぼす神経成長因子の作用

  五十嵐 康; 神戸 直智; 天野 博雄; 黒沢 元博; 宮地 良樹; 斉藤 博久; 飯倉 洋治; 中畑 龍俊; 松田 浩珍

  アレルギー, 1995

  

External funds: Kakenhi

• Analysis of molecular mechanism of granuloma formation by autoinflammation

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53050:Dermatology-related

  Kyoto University;Kansai Medical University

  Naotomo Kambe

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  肉芽腫;iPS細胞;ブラウ症候群;自然免疫;プロテオミクス;リン酸化蛋白;自己炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08784/
• Gene-based analysis of NETs-associated DNA in autoantibody-mediated diseases

  Grant-in-Aid for Challenging Exploratory Research

  Chiba University

  YUMI MATSUOKA

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  皮膚科学;血管炎;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670519/
• Application for a new less-invasive, personalized 3-demensional epidermal model: Search for new responsible genes related to Atopic Dermatitis

  Grant-in-Aid for Scientific Research (B)

  Chiba University

  Hiroyuki Matsue

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  ケラチノサイト;三次元表皮;アトピー性皮膚炎;責任遺伝子;毛包;皮膚免疫学;皮膚炎症学;３次元方法由来表皮;ｱﾄﾋﾟｰ性皮膚炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293255/
• Gene analysis of epidermal gap junction and pathological search for palmoplantar hyperkeratosis associated with hearing impairments

  Grant-in-Aid for Challenging Exploratory Research

  Chiba University

  Naotomo KAMBE

  From 01 Apr. 2011, To 31 Mar. 2012, Project Closed

  皮膚病理学;角化症;皮膚科学;遺伝子;Gap junction;コネキシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659542/
• Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology

  Grant-in-Aid for Scientific Research (B)

  Chiba University

  Naotomo KAMBE

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  皮膚炎症・再生学;肉芽腫;NOD2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390280/
• Analysis and development of medical treatment for autoinflammatory diseases

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  TOSHIO HEIKE

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  自己炎症性疾患;インフラマソーム;モザイシズム;CAPS;高IgD症候群;NLRP3;インフラマゾーム;次世代シークエンサー;軟骨細胞;自然免疫;自己炎症疾患;mevalonate kinase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23249056/
• Pathological analysis of skin fibrosis, focused on type 2 innate immune lymphoid cells

  Grant-in-Aid for Challenging Exploratory Research

  Chiba University

  Naotomo KAMBE

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  皮膚炎症・再生学;皮膚硬化性病変;ＩＬ-33

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659520/
• インフラマソームの構成成分が関わる細胞死の人為的制御系の確立とそのメカニズム解明

  Grant-in-Aid for Challenging Exploratory Research

  Chiba University

  神戸 直智

  From 01 Apr. 2010, To 31 Mar. 2011, Project Closed

  皮膚科学;炎症;IL-1β;NLRP3;インフラマソーム;細胞死;カテプシン阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659203/
• インフラマソームを介した悪性黒色腫の増殖および転移に関する研究

  Grant-in-Aid for Challenging Exploratory Research

  Chiba University

  神戸 直智

  From 01 Apr. 2009, To 31 Mar. 2010, Project Closed

  皮膚科学;悪性腫瘍;転移;悪性黒色腫;炎症;IL-1β;インフラマソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659265/
• 抗ヒスタミン薬治療抵抗性慢性蕁麻疹におけるIL-1βを起点とする炎症病態の解明

  Grant-in-Aid for Scientific Research (C)

  Chiba University

  岩澤 真理

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  皮膚科学;炎症;IL-1β;NLRP3;インフラマソーム;IL-17

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591455/
• Analysis of regulation of inflammation on the skin : Toward development of platform for new anti-inflammatory drug

  Grant-in-Aid for Scientific Research (B)

  Chiba University

  Hiroyuki MATSUE

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  内科;免疫学;生体分子;薬剤反応性;臨床;樹状細胞;ギャップ結合;免疫抑制;抗炎症剤;接触皮膚炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390324/
• Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Ryuta NISHIKOMORI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  小児免疫;アレルギー;膠原病;CINCA症候群;NLRP3;体細胞モザイク;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390310/
• DC Hybrids:皮膚自己免疫性疾患モデルの開発

  Grant-in-Aid for Exploratory Research

  Chiba University

  松江 弘之

  From 01 Apr. 2007, To 31 Mar. 2008, Project Closed

  内科;病理学;バイオテクノロジー;免疫学;臨床;樹状細胞;自己免疫性疾患;動物モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19659281/
• Molecular mechanism of cell death induced by the activation of intracellular pattern recognition receptor, cryopyrin

  Grant-in-Aid for Scientific Research (C)

  Chiba University

  Naotomo KAMBE

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  皮膚感染症;免疫学;NLRP3;CIAS1;cryopyrin;細胞内パターン認識受容体;細胞死;ASC;cathepsin B;細胞内微生物認識受容体;catyepsinB;TAPtag法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591303/
• Study on causes and pathophysiology of CINCA syndrome patients without CIAS1 gene mutations

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Ryuta NISHIKOMORI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  小児免疫・アレルギー・膠原病学;CINCA症候群;CIAS1;体細胞モザイク;自己炎症症候群;自己炎症性疾患;NLRP3;体細胞モデイク

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591249/
• 免疫・炎症反応におけるギャップ結合の機能の解析及びギャップ結合阻害外用剤の開発

  Grant-in-Aid for Scientific Research (B)

  Chiba University

  松江 弘之

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  樹状細胞;ギャップ結合;免疫抑制;抗炎症作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390311/
• 肥満細胞の活性化および分化における家族性寒冷刺激蕁麻疹原因遺伝子の役割

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  神戸 直智

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  肥満細胞;家族性寒冷蕁麻疹;自己炎症性疾患;自然免疫;パターン認識受容体;CINCA症候群

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17790766/
• 肥満細胞が形質細胞様樹状細胞の分化・機能に与える影響についての検証

  Grant-in-Aid for Exploratory Research

  Kyoto University

  神戸 直智

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  肥満細胞;形質細胞様樹状細胞;肥満細胞欠損マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659291/
• ヒト皮膚結合織型肥満細胞大量純粋培養系をモデルとした肥満細胞増殖機構の解明

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  神戸 直智

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  肥満細胞;CD13;aminopeptidase N;細胞増殖;免疫不全マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14770405/
• Regulatory Mechanisms of Granulomatous Inflammation Focusing on Post-translational Modifications

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53050:Dermatology-related

  Kyoto University

  神戸 直智

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  肉芽腫;自己炎症;ブラウ症候群;翻訳後修飾;ユビキチン化;NOD2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08380/

External funds: others

• 難治性疾患政策研究事業 (2022年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  研究分担者
• 難治性疾患政策研究事業 (2021年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  分担
• （2020度分）

  難治性疾患政策研究事業

  From 01 Apr. 2020, To 31 Mar. 2021

  分担

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology II

  8031, Spring, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pathophysiology

  M044, Spring, Graduate School of Medicine, 2

Academic, Social Contribution

Committee Memberships

• From Oct. 2022, To Present

  代議員, 日本アレルギー学会
• From Jul. 2017, To Present

  理事, 日本免疫不全・自己炎症学会
• From Apr. 2017, To Present

  代議員，中部支部, 日本皮膚科学会
• From Apr. 2016, To Present

  英文会誌 Allergol IntのSection Editor, 日本アレルギー学会
• From Dec. 2012, To Present

  代議員, 日本皮膚アレルギー接触皮膚炎学会

Social Contribution

• 難病情報センター情報企画委員

  Official expert

  From Dec. 2014