Basic Information

Faculty

• 医学部

Professional Memberships

• 日本細菌学会
• 分子生物学会
• 基礎歯科医学会
• 国際歯科医学会

Academic Degree

• Doctor of Dental Sciences (DDS)(Osaka University)

Academic Resume (Graduate Schools)

• Osaka University, Graduate School of Dental Sciences, 修了

Academic Resume (Undergraduate School/Majors)

• Osaka University, Faculty of Dentistry, 卒業

Research History

• From 2014, To Present

  Kyoto University, Graduate School of Medicine, Department of Microbiology, Professor
• From 2009, To 2014

  Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Oral Health Sciences Oral Restitution, Professor
• From 2006, To 2009

  The University of Tokyo, The Institute of Medical Science, 准教授
• From 2000, To 2006

  Osaka University, School of Dentistry, 講師
• From 1997, To 2000

  Osaka University, School of Dentistry, 助手

Profile

• Profile

  1992年大阪大学歯学部卒業
  
  1996年大阪大学大学院歯学研究科修了、歯学博士
  
  1997年大阪大学歯学部・助手
  
  2000年大阪大学歯学部・講師
  
  2006年東京大学医科学研究所感染症国際研究センター・助教授
  
  2007年東京大学医科学研究所感染症国際研究センター・准教授
  
  2009年東京医科歯科大学大学院医歯学総合研究科・教授
  
  2014年京都大学大学院医学研究科・教授

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201001037403837032

• Researcher number

  70294113

researchmap URL

• https://researchmap.jp/read0054817

Research

Research Topics, Overview of the research

• Research Topics

  Elucidation of survival strategy of bacteria based on whole genome analysis and microbiome analysis
  Analysis of foreign gene acquisition function and evolutionary mechanism of pathogenic bacteria by comparative genome analysis
  Analysis of recognition and elimination mechanism of intracellular invasive bacteria
  Development of novel infectious disease therapeutics based on genomic information
  

• Overview of the research

  Up to today, the emphasis of prevention and treatment for bacterial infectious disease has been on the development of antibiotics and vaccines. However, it is difficult to eliminate a specific pathogen by antibiotics because of their properties, and the excessive administration of antibiotics causes the spread of drug-resistant bacteria and dysbiosis. Therefore, it is especially expected to develop novel drugs with a specific effect against each bacterial pathogen.
  The purpose of this study is to establish an effective and large-scale screening system for isolating the functional molecules which can effectively inhibit the interaction between bacterial molecules and host molecules, especially for protein-protein interaction. For this purpose, we develop two screening systems, one is the low molecular weight compounds and the other is nanobodies (VHH), and try to isolate validate candidate substances as seeds for molecular targeted drugs that can prevent and control specific bacterial infection.
  We have already found a low molecular weight compound that showed a strong growth inhibition against Group A Streptococcus (GAS). This compound could inhibit the binding between of Shr, a hemoprotein receptor (iron transporter) of GAS, and the hemoglobin. This compound showed a strong specificity against GAS, and no inhibitory activity against gram-negative bacteria and other gram-positive bacteria. These observations suggest the possibility to develop new drugs targeting specific bacterial species.
  In this application, we focus on two bacterial species, Staphylococcus aureus (becoming increasingly resistant to antibiotics) and GAS (causing serious invasive infections such as necrotizing fasciitis and streptococcal toxic shock syndrome) to find novel growth inhibitory molecules. We precisely characterize the conformation and physical-chemical properties between target bacterial molecules and host molecules based on the crystal structure, and also establish a screening system that can effectively and high-sensitively analyze the binding state between them. The candidate substances are used as lead compounds for chemical modifications or genetic modifications, and the most effective substance is selected for further analysis. We also construct gene knockout mutants or amino acid substitution mutants of putative binding sites for the candidate substances in target bacteria, and evaluate the effect of these candidates for comparing the growth of these parents strains and mutants and the risk for acquisition of drug resistance. Finally, we evaluate toxicity and protective ability of candidate compounds by animal experiments using mice.
  We believe that this study might become a milestone providing a new treatment strategy for multidrug-resistant bacterial infection and intractable infectious diseases.
  

Research Interests

• Antibody
• Pharmacology
• 病原性
• Bacteriology
• ゲノム
• 細胞生物学
• 感染症
• genome
• cell biology
• infectious diseases

Research Areas

• Life sciences, Bacteriology, Bactreriology
• Life sciences, Oral medicine

Papers

• Complete genome sequence of three Staphylococcus epidermidis strains isolated from patients with skin diseases in Japan.

  Yu Kawagishi; Teresia M Kimeu; Kazunori Murase; Akemi Yoshida; Atsuko Minowa-Nozawa; Takashi Nozawa; Yasuhiro Tsuchido; Taro Noguchi; Miki Nagao; Saeko Nakajima; Ichiro Nakagawa

  Microbiology resource announcements, 20 Jun. 2024, Peer-reviewed

  
• Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.

  Risa Asano; Miyu Takeuchi; Makoto Nakakido; Sho Ito; Chihiro Aikawa; Takeshi Yokoyama; Akinobu Senoo; Go Ueno; Satoru Nagatoishi; Yoshikazu Tanaka; Ichiro Nakagawa; Kouhei Tsumoto

  Protein science : a publication of the Protein Society, Jun. 2024, Peer-reviewed

  
• ATG9B regulates bacterial internalization via actin rearrangement.

  Junpei Iibushi; Takashi Nozawa; Hirotaka Toh; Ichiro Nakagawa

  iScience, 17 May 2024, Peer-reviewed

  
• Structural basis for the recognition of human hemoglobin by the heme-acquisition protein Shr from Streptococcus pyogenes

  Akinobu Senoo; Masato Hoshino; Toshiki Shiomi; Makoto Nakakido; Satoru Nagatoishi; Daisuke Kuroda; Ichiro Nakagawa; Jeremy R. H. Tame; Jose M. M. Caaveiro; Kouhei Tsumoto

  Scientific Reports, 05 Mar. 2024, Peer-reviewed

  
• Characterization of pig tonsils as niches for the generation of Streptococcus suis diversity

  Kai Kobayashi; Hiroaki Kubota; Mari Tohya; Megumi Ushikubo; Miki Yamamoto; Tsukasa Ariyoshi; Yumi Uchitani; Morika Mitobe; Rumi Okuno; Ichiro Nakagawa; Tsutomu Sekizaki; Jun Suzuki; Kenji Sadamasu

  Veterinary Research, 06 Feb. 2024, Peer-reviewed

  
• Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy

  Takashi Nozawa; Hirotaka Toh; Junpei Iibushi; Kohei Kogai; Atsuko Minowa-Nozawa; Junko Satoh; Shinji Ito; Kazunori Murase; Ichiro Nakagawa

  Nature Communications, 06 Oct. 2023, Peer-reviewed

  
• Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes.

  Taichi Yamazaki; Satoru Nagatoishi; Tsukushi Yamawaki; Takashi Nozawa; Ryo Matsunaga; Makoto Nakakido; Jose M M Caaveiro; Ichiro Nakagawa; Kouhei Tsumoto

  The Journal of biological chemistry, 14 Sep. 2023, Peer-reviewed

  
• Group A Streptococcus cation diffusion facilitator proteins contribute to immune evasion by regulating intracellular metal concentrations.

  Chihiro Aikawa; Akihide Shimizu; Makoto Nakakido; Kazunori Murase; Takashi Nozawa; Kouhei Tsumoto; Ichiro Nakagawa

  Biochemical and biophysical research communications, 24 Jul. 2023, Peer-reviewed

  
• Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation

  Miyako Hikichi; Hirotaka Toh; Atsuko Minowa-Nozawa; Takashi Nozawa; Ichiro Nakagawa

  Cellular Microbiology, 2022, Peer-reviewed

  
• Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth.

  Sandra Valenciano-Bellido; Jose M M Caaveiro; Makoto Nakakido; Daisuke Kuroda; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto

  The Journal of biological chemistry, 15 Jun. 2023, Peer-reviewed

  
• Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005-2021.

  Shinohara K; Murase K; Tsuchido Y; Noguchi T; Yukawa S; Yamamoto M; Matsumura Y; Nakagawa I; Nagao M

  Emerging infectious diseases, 01 Mar. 2023, Peer-reviewed

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• マウスでのkgpDNAワクチンPorphyromonas gingivalis感染防御効果

  久保庭 雅恵; 天野 敦雄; 中川 一路; 雫石 聰; 浜田 茂幸

  日本細菌学雑誌, Apr. 2000

  
• Genomic dissection of the Vibrio cholerae O-serogroup global reference strains: reassessing our view of diversity and plasticity between two chromosomes.

  Kazunori Murase; Eiji Arakawa; Hidemasa Izumiya; Atsushi Iguchi; Taichiro Takemura; Taisei Kikuchi; Ichiro Nakagawa; Nicholas R Thomson; Makoto Ohnishi; Masatomo Morita

  Microbial genomics, Aug. 2022, Peer-reviewed

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• Complete Genome Sequences of Three Streptococcus ruminantium Strains Obtained from Endocarditis Lesions of Cattle in Japan.

  Ryohei Nomoto; Kasumi Ishida-Kuroki; Mari Tohya; Ichiro Nakagawa; Tsutomu Sekizaki

  Microbiology resource announcements, 19 May 2022, Peer-reviewed

  
• Complete Genome Sequences of Four Streptococcus parasuis Strains Obtained from Saliva of Domestic Pigs in Japan.

  Ryohei Nomoto; Kasumi Ishida-Kuroki; Ichiro Nakagawa; Tsutomu Sekizaki

  Microbiology resource announcements, 17 Feb. 2022, Peer-reviewed

  
• FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan.

  Akihiro Yamada; Miyako Hikichi; Takashi Nozawa; Ichiro Nakagawa

  EMBO reports, 04 Nov. 2021, Peer-reviewed

  
• An In Vitro Mixed Infection Model With Commensal and Pathogenic Staphylococci for the Exploration of Interspecific Interactions and Their Impacts on Skin Physiology.

  Katsunori Kohda; Xuan Li; Naoki Soga; Risa Nagura; Tie Duerna; Saeko Nakajima; Ichiro Nakagawa; Masakazu Ito; Akinori Ikeuchi

  Frontiers in cellular and infection microbiology, 2021

  
• Correction: Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis.

  Yukiko Ohara; Yuriko Ozeki; Yoshitaka Tateishi; Tsukasa Mashima; Fumio Arisaka; Yasuo Tsunaka; Yoshie Fujiwara; Akihito Nishiyama; Yutaka Yoshida; Kengo Kitadokoro; Haruka Kobayashi; Yukihiro Kaneko; Ichiro Nakagawa; Ryoji Maekura; Saburo Yamamoto; Masato Katahira; Sohkichi Matsumoto

  PloS one, 2021

  
• Biological Effect of Streptococcus pyogenes-Released Extracellular Vesicles on Human Monocytic Cells, Induction of Cytotoxicity, and Inflammatory Response.

  Kazunori Murase; Chihiro Aikawa; Takashi Nozawa; Ayako Nakatake; Kuniyo Sakamoto; Taisei Kikuchi; Ichiro Nakagawa

  Frontiers in cellular and infection microbiology, 19 Jul. 2021

  
• Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor.

  Tsukushi Yamawaki; Makoto Nakakido; Kan Ujiie; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto

  Biochemical and biophysical research communications, 06 Aug. 2021, Peer-reviewed

  
• Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.

  Chihiro Aikawa; Kiyosumi Kawashima; Chihiro Fukuzaki; Makoto Nakakido; Kazunori Murase; Takashi Nozawa; Kouhei Tsumoto; Ichiro Nakagawa

  Biochemical and biophysical research communications, 12 Jun. 2021, Peer-reviewed

  
• Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering.

  Masahiro Shimogishi; Takayasu Watanabe; Masaki Shibasaki; Takahiko Shiba; Keiji Komatsu; Takashi Nemoto; Kazuyuki Ishihara; Yoshio Nakano; Takanori Iwata; Shohei Kasugai; Ichiro Nakagawa

  Journal of periodontal research, 31 May 2021, Peer-reviewed

  
• Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase.

  Takashi Nozawa; Junpei Iibushi; Hirotaka Toh; Atsuko Minowa-Nozawa; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa

  mBio, 09 Feb. 2021, Peer-reviewed

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• Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs.

  Atsuko Minowa-Nozawa; Takashi Nozawa; Daisuke Takamatsu; Akemi Yoshida; Kazunori Murase; Taisei Kikuchi; Kasumi Ishida-Kuroki; Yoshihiro Nitta; Tsutomu Sekizaki; Ichiro Nakagawa

  Microbiology resource announcements, 19 Nov. 2020, Peer-reviewed

  
• Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 2009.

  Kazunori Murase; Takashi Nozawa; Chihiro Aikawa; Miki Nagao; Tadayoshi Ikebe; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa

  Microbiology resource announcements, 15 Oct. 2020, Peer-reviewed

  
• Complete Genome Sequence of Helicobacter pylori Strain ATCC 43504, a Type Strain That Can Infect Gerbils.

  Ryo Kinoshita-Daitoku; Yoshitoshi Ogura; Kotaro Kiga; Fumito Maruyama; Tomoyo Kondo; Ichiro Nakagawa; Tetsuya Hayashi; Hitomi Mimuro

  Microbiology resource announcements, 30 Apr. 2020, Peer-reviewed

  
• Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.

  Mototsugu Tanaka; Ryo Kinoshita-Daitoku; Kotaro Kiga; Takahito Sanada; Bo Zhu; Tokuju Okano; Chihiro Aikawa; Tamako Iida; Yoshitoshi Ogura; Tetsuya Hayashi; Koshu Okubo; Miho Kurosawa; Junichi Hirahashi; Toshihiko Suzuki; Ichiro Nakagawa; Masaomi Nangaku; Hitomi Mimuro

  Scientific reports, 24 Feb. 2020, Peer-reviewed

  
• Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.

  Ichiro Takahashi; Koji Hosomi; Takahiro Nagatake; Hirokazu Toubou; Daiki Yamamoto; Ikue Hayashi; Yosuke Kurashima; Shintaro Sato; Naoko Shibata; Yoshiyuki Goto; Fumito Maruyama; Ichiro Nakagawa; Asaomi Kuwae; Akio Abe; Jun Kunisawa; Hiroshi Kiyono

  International immunology, 07 Feb. 2020, Peer-reviewed

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• TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.

  Takashi Nozawa; Shunsuke Sano; Atsuko Minowa-Nozawa; Hirotaka Toh; Shintaro Nakajima; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa

  Nature communications, 07 Feb. 2020, Peer-reviewed

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• Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy.

  Hirotaka Toh; Takashi Nozawa; Atsuko Minowa-Nozawa; Miyako Hikichi; Shintaro Nakajima; Chihiro Aikawa; Ichiro Nakagawa

  Autophagy, Feb. 2020, Peer-reviewed

  
• Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles.

  Takashi Nozawa; Ichiro Nakagawa

  Methods in molecular biology (Clifton, N.J.), 2020

  
• Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection.

  Ching-Yu Lin; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Miyako Hikichi; Junpei Iibushi; Ichiro Nakagawa

  Frontiers in cellular and infection microbiology, 2020, Peer-reviewed

  
• Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity

  Kaori Fujiwara-Takahashi; Takayasu Watanabe; Masahiro Shimogishi; Masaki Shibasaki; Makoto Umeda; Yuichi Izumi; Ichiro Nakagawa

  Journal of Oral Microbiology, 01 Jan. 2020, Peer-reviewed

  
• Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan.

  Miyako Hikichi; Miki Nagao; Kazunori Murase; Chihiro Aikawa; Takashi Nozawa; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa

  Microbiology resource announcements, 21 Nov. 2019, Peer-reviewed

  
• 16S rRNA Gene Amplicon Sequence Data from Chicken Cecal Feces from Vietnam and Thailand.

  N Takeshita; H Kim; K Witoonsatian; M Tohya; TH Võ; N Boonyong; TPB Nguyễn; I Nakagawa; N Meekhanon; NH Nguyễn; T Sekizaki

  Microbiology resource announcements, Aug. 2019, Peer-reviewed

  
• LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy.

  CY Lin; T Nozawa; A Minowa-Nozawa; H Toh; C Aikawa; I Nakagawa

  Cellular microbiology, Apr. 2019, Peer-reviewed

  
• Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients.

  K Funahashi; T Shiba; T Watanabe; K Muramoto; Y Takeuchi; T Ogawa; Y Izumi; T Sekizaki; I Nakagawa; K Moriyama

  Progress in orthodontics, Mar. 2019, Peer-reviewed

  
• Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203).

  K Nagaoka; S Konno; K Murase; T Kikuchi; Y Morinaga; K Yanagihara; I Nakagawa

  Microbiology resource announcements, Feb. 2019, Peer-reviewed

  
• Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.

  Hirotaka Toh; Ching-Yu Lin; Shintaro Nakajima; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa

  Frontiers in cellular and infection microbiology, 2019, Peer-reviewed

  
• Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus.

  Shunsuke Yamada; Masaki Shibasaki; Kazunori Murase; Takayasu Watanabe; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa

  BMC microbiology, Jan. 2019, Peer-reviewed

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• Characterization of pig saliva as the major natural habitat of Streptococcus suis by analyzing oral, fecal, vaginal, and environmental microbiota.

  K Murase; T Watanabe; S Arai; H Kim; M Tohya; K Ishida-Kuroki; TH Võ; TPB Nguyễn; I Nakagawa; R Osawa; NH Nguyễn; T Sekizaki

  PloS one, 2019, Peer-reviewed

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• Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 335 Strain HU-GS5823, Isolated from a Human Patient in Japan with Severe Invasive Infection.

  K Nagaoka; S Konno; K Murase; T Kikuchi; I Nakagawa

  Microbiology resource announcements, Nov. 2018, Peer-reviewed

  
• RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus.

  Koji Nakajima; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Shunsuke Yamada; Chiro Aikawa; Ichiro Nakagawa

  Autophagy, Oct. 2018, Peer-reviewed

  
• Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay

  S Arai; H Kim; T Watanabe; M Tohya; E Suzuki; K Ishida-Kuroki; F Maruyama; K Murase; I Nakagawa; T Sekizaki

  American Journal of Veterinary Research, Sep. 2018, Peer-reviewed

  
• Distribution of single nucleotide polymorphisms in protein-coding regions of emm12 Group A Streptococcus from two scarlet fever outbreaks

  M Shibasaki; T Watanabe; S Kasugai; I Nakagawa

  J Stomatol Soc Jpn, Mar. 2018, Peer-reviewed

  
• Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing

  K Okada; W Wongboot; S Chantaroj; W Natakuathung; A Roobthaisong; W Kamjumphol; F Maruyama; T Takemura; I Nakagawa; M Ohnishi; S Hamada

  Scientific Reports, Jan. 2018, Peer-reviewed

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• Pig saliva as a Streptococcus suis reservoir and potential source of infection on farms: Implications from a novel quantitative PCR.

  S Arai; H Kim; T Watanabe; M Tohya; E Suzuki; K Ishida-Kuroki; F Maruyama; K Murase; I Nakagawa; T Sekizaki

  American Journal of Veterinary Research, 2018, Peer-reviewed

  
• NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex.

  Chihiro Aikawa; Shintaro Nakajima; Miho Karimine; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Shunsuke Yamada; Ichiro Nakagawa

  Frontiers in cellular and infection microbiology, 2018, Peer-reviewed

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• Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis.

  Y Ohara; Y Ozeki; Y Tateishi; T Mashima; F Arisaka; Y Tsunaka; Y Fujiwara; A Nishiyama; Y Yoshida; K Kitadokoro; H Kobayashi; Y Kaneko; I Nakagawa; R Maekura; S Yamamoto; M Katahira; S Matsumoto

  PloS ONE, 2018, Peer-reviewed

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• Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2

  Kouyuki Hirayasu; Fumiji Saito; Tadahiro Suenaga; Kyoko Shida; Noriko Arase; Keita Oikawa; Toshifumi Yamaoka; Hiroyuki Murota; Hiroji Chibana; Ichiro Nakagawa; Tomoko Kubor; Hiroki Nagai; Yuji Nakamaru; Ichiro Katayama; Marco Colonna; Hisashi Arase

  CYTOKINE, Dec. 2017

  
• Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes

  Masato Hoshino; Makoto Nakakido; Satoru Nagatoishi; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2017, Peer-reviewed

  
• Erruatum to: Rab35 GTPase recruits NDP52 to autophagy targets. (EMBO Journal, 2017, 36, 18, 2790-2807)

  Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa

  EMBO Journal, Nov. 2017, Peer-reviewed

  
• Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam

  Taichiro Takemura; Kazunori Murase; Fumito Maruyama; Thi Luong Tran; Atsushi Ota; Ichiro Nakagawa; Dong Tu Nguyen; Tu Cuong Ngo; Thi Hang Nguyen; Asako Tokizawa; Masatomo Morita; Makoto Ohnishi; Binh Minh Nguyen; Tetsu Yamashiro

  INFECTION GENETICS AND EVOLUTION, Oct. 2017, Peer-reviewed

  
• Rab35 GTPase recruits NPD52 to autophagy targets

  Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa

  EMBO JOURNAL, Sep. 2017, Peer-reviewed

  
• Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis

  Hirokazu Yano; Tomotada Lwamoto; Yukiko Nishiuchi; Chie Nakajima; Daria A. Starkova; Igor Mokrousov; Olga Narvskaya; Shiomi Yoshida; Kentaro Arikawa; Noriko Nakanishi; Ken Osaki; Ichiro Nakagawa; Manabu Ato; Yasuhiko Suzuki; Fumito Maruyama

  GENOME BIOLOGY AND EVOLUTION, Sep. 2017, Peer-reviewed

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• Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species

  Takayasu Watanabe; Masaki Shibasaki; Fumito Maruyama; Tsutomu Sekizaki; Ichiro Nakagawa

  PLOS ONE, Aug. 2017, Peer-reviewed

  
• A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis

  Masatoshi Okura; Takashi Nozawa; Takayasu Watanabe; Kazunori Murase; Ichiro Nakagawa; Daisuke Takamatsu; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Shigeyuki Hamada; Fumito Maruyama

  GENOME BIOLOGY AND EVOLUTION, Apr. 2017, Peer-reviewed

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• Active microbiota show specific correlationships in peri-implantitis and periodontitis

  H Kachi; N Maruyama; F Maruyama; T Shiba; T Watanabe; A Goda; K Murase; Y Michi; Y Takeuchi; Y Izumi; K Harada; I Nakagawa

  J Stomatol Soc Jpn, Mar. 2017, Peer-reviewed

  
• Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG

  Shintaro Nakajima; Chihiro Aikawe; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Ichiro Nakagawa

  PLOS ONE, Jan. 2017, Peer-reviewed

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• The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

  Takashi Nozawa; Atsuko Minowa-Nozawa; Chihiro Aikawa; Ichiro Nakagawa

  AUTOPHAGY, 2017, Peer-reviewed

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• The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation

  Takashi Nozawa; Chihiro Aikawa; Atsuko Minowa-Nozawa; Ichiro Nakagawa

  AUTOPHAGY, 2017, Peer-reviewed

  
• YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses

  Amonrattana Roobthaisong; Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Ichiro Nakagawa

  PLOS ONE, Jan. 2017, Peer-reviewed

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• DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan

  Tejaswini Kulkarni; Chihiro Aikawa; Takashi Nozawa; Kazunori Murase; Fumito Maruyama; Ichiro Nakagawa

  BMC MICROBIOLOGY, Oct. 2016, Peer-reviewed

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• Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms

  Takahiko Shiba; Takayasu Watanabe; Hirokazu Kachi; Tatsuro Koyanagi; Noriko Maruyama; Kazunori Murase; Yasuo Takeuchi; Fumito Maruyama; Yuichi Izumi; Ichiro Nakagawa

  SCIENTIFIC REPORTS, Aug. 2016, Peer-reviewed

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• Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones

  Mari Tohya; Takayasu Watanabe; Fumito Maruyama; Sakura Arai; Atsushi Ota; Taryn B. T. Athey; Nahuel Fittipaldi; Ichiro Nakagawa; Tsutomu Sekizaki

  PLOS ONE, Jul. 2016, Peer-reviewed

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• Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1.

  T Furusawa; H Iwano; H Higuchi; M Usui; F Maruyama; I Nakagawa; H Yokota; Y Tamura

  Genome Announcements, May 2016, Peer-reviewed

  
• Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2.

  Kouyuki Hirayasu; Fumiji Saito; Tadahiro Suenaga; Kyoko Shida; Noriko Arase; Keita Oikawa; Toshifumi Yamaoka; Hiroyuki Murota; Hiroji Chibana; Ichiro Nakagawa; Tomoko Kubori; Hiroki Nagai; Yuji Nakamaru; Ichiro Katayama; Marco Colonna; Hisashi Arase

  Nature microbiology, 25 Apr. 2016, Peer-reviewed

  
• Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand

  W Paveenkittiporn; T Nozawa; S Dejsirilert; I Nakagawa; S Hamada

  EPIDEMIOLOGY AND INFECTION, Mar. 2016, Peer-reviewed

  
• Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes

  Seiichiro Oda; Takashi Nozawa; Atsuko Nozawa-Minowa; Misako Tanaka; Chihiro Aikawa; Hiroyuki Harada; Ichiro Nakagawa

  PLOS ONE, Jan. 2016, Peer-reviewed

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• Streptococcus pyogenes Genomics

  F Maruyama; T Watanabe; I Nakagawa

  Streptococcus pyogenes : Basic Biology to Clinical Manifestations, 2016, Peer-reviewed

  
• Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172

  Takayuki Wada; Fumito Maruyama; Tomotada Iwamoto; Shinji Maeda; Taro Yamamoto; Ichiro Nakagawa; Saburo Yamamoto; Naoya Ohara

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

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• Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes

  Shigeyuki Hamada; Shigetada Kawabata; Ichiro Nakagawa

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, Dec. 2015, Peer-reviewed

  
• Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae

  Kazuhisa Okada; Wirongrong Natakuathung; Mathukorn Na-Ubol; Amonrattana Roobthaisong; Warawan Wongboot; Fumito Maruyama; Ichiro Nakagawa; Siriporn Chantaroj; Shigeyuki Hamada

  EMERGING INFECTIOUS DISEASES, Jul. 2015, Peer-reviewed

  
• Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates

  Kana Minegishi; Takayasu Watanabe; Asuka Furukawa; Keisuke Uchida; Yoshimi Suzuki; Takumi Akashi; Fumito Maruyama; Ichiro Nakagawa; Yoshinobu Eishi

  SCIENTIFIC REPORTS, May 2015, Peer-reviewed

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• Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease

  Akiko Endo; Takayasu Watanabe; Nachiko Ogata; Takashi Nozawa; Chihiro Aikawa; Shinichi Arakawa; Fumito Maruyama; Yuichi Izumi; Ichiro Nakagawa

  ISME JOURNAL, Mar. 2015, Peer-reviewed

  
• Rab Proteins in Autophagy: Streptococcus Model

  T Nozawa; I Nakagawa

  Autophagy, Infection, and the Immune Response, Feb. 2015, Peer-reviewed

  
• Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion

  Bijaya Haobam; Takashi Nozawa; Atsuko Minowa-Nozawa; Misako Tanaka; Seiichiro Oda; Takayasu Watanabe; Chihiro Aikawa; Fumito Maruyama; Ichiro Nakagawa

  CELLULAR MICROBIOLOGY, Dec. 2014, Peer-reviewed

  
• Evaluation of biofilm formation in the presence of saliva on poly(ethylene-glycol)-deposited titanium

  Ayako Kawabe; Ichiro Nakagawa; Zuisei Kanno; Yusuke Tsutsumi; Takao Hanawa; Takashi Ono

  DENTAL MATERIALS JOURNAL, Oct. 2014, Peer-reviewed

  
• Intraindividual variation in core microbiota in peri-implantitis and periodontitis

  Noriko Maruyama; Fumito Maruyama; Yasuo Takeuchi; Chihiro Aikawa; Yuichi Izumi; Ichiro Nakagawa

  SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed

  
• The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation

  Makoto Nakakido; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto

  JOURNAL OF BIOCHEMISTRY, Sep. 2014, Peer-reviewed

  
• Comparative Genomic Characterization of a Thailand-Myanmar Isolate, MS6, of Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a "US Gulf Coast" Clone

  Kazuhisa Okada; Mathukorn Na-Ubol; Wirongrong Natakuathung; Amonrattana Roobthaisong; Fumito Maruyama; Ichiro Nakagawa; Siriporn Chantaroj; Shigeyuki Hamada

  PLOS ONE, Jun. 2014, Peer-reviewed

  
• Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis

  Masatoshi Okura; ClauDe lachance; Makoto Osaki; Tsutomu Sekizaki; Fumito Maruyama; Takashi Nozawa; Ichiro Nakagawa; Shigeyuki Hamada; Celine Rossignol; Marcelo Gottschalk; Daisuke Takamatsu

  JOURNAL OF CLINICAL MICROBIOLOGY, May 2014, Peer-reviewed

  
• Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw

  A Goda; F Maruyama; Y Michi; I Nakagawa; K Harada

  CLINICAL MICROBIOLOGY AND INFECTION, May 2014, Peer-reviewed

  
• Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011.

  Naomi Ohnishi; Fumito Maruyama; Hirohito Ogawa; Hirokazu Kachi; Shunsuke Yamada; Daisuke Fujikura; Ichiro Nakagawa; Mudenda B. Hang'ombe; Yuka Thomas; Aaron S. Mweene; Hideaki Higashi

  Genome Announcements, Mar. 2014, Peer-reviewed

  
• Streptococcus pyogenes Escapes from Autophagy

  Ichiro Nakagawa

  CELL HOST & MICROBE, Dec. 2013, Peer-reviewed

  
• Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria

  Chiaki Ito; Yohei Saito; Takashi Nozawa; Shigemoto Fujii; Tomohiro Sawa; Hirofumi Inoue; Tetsuro Matsunaga; Shahzada Khan; Soichiro Akashi; Ryota Hashimoto; Chihiro Aikawa; Eriko Takahashi; Hiroshi Sagara; Masaaki Komatsu; Keiji Tanaka; Takaaki Akaike; Ichiro Nakagawa; Hirokazu Arimoto

  MOLECULAR CELL, Dec. 2013, Peer-reviewed

  
• Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation

  Masatoshi Okura; Daisuke Takamatsu; Fumito Maruyama; Takashi Nozawa; Ichiro Nakagawa; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Yumi Kumagai; Shigeyuki Hamada

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Apr. 2013, Peer-reviewed

  
• CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination

  Takayasu Watanabe; Takashi Nozawa; Chihiro Aikawa; Atsuo Amano; Fumito Maruyama; Ichiro Nakagawa

  GENOME BIOLOGY AND EVOLUTION, 2013, Peer-reviewed

  
• Molecular typing of Streptococcus mutans

  K Nakano; I Nakagawa; S Alaluusua; T Ooshima

  Molecular Typing in Bacterial Infections, Jan. 2013, Peer-reviewed

  
• Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient.

  K Minegishi; C Aikawa; A Furukawa; T Watanabe; T Nakano; Y Ogura; Y Ohtsubo; K Kurokawa; T Hayashi; F Maruyama; I Nakagawa; Y Eishi

  Genome Announcements, Jan. 2013, Peer-reviewed

  
• Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis

  Manabu Ogawa; Sunao Sugita; Norio Shimizu; Ken Watanabe; Ichiro Nakagawa; Manabu Mochizuki

  JAPANESE JOURNAL OF OPHTHALMOLOGY, Nov. 2012, Peer-reviewed

  
• The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection

  Takashi Nozawa; Chihiro Aikawa; Akira Goda; Fumito Maruyama; Shigeyuki Hamada; Ichiro Nakagawa

  CELLULAR MICROBIOLOGY, Aug. 2012, Peer-reviewed

  
• Complete Genome Sequence of the Serotype k Streptococcus mutans Strain LJ23

  Chihiro Aikawa; Nayuta Furukawa; Takayasu Watanabe; Kana Minegishi; Asuka Furukawa; Yoshinobu Eishi; Kenshiro Oshima; Ken Kurokawa; Masahira Hattori; Kazuhiko Nakano; Fumito Maruyama; Ichiro Nakagawa; Takashi Ooshima

  JOURNAL OF BACTERIOLOGY, May 2012, Peer-reviewed

  
• Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis

  Akinobu Aoki; Yasuko Shibata; Soichiro Okano; Fumito Maruyama; Atsuo Amano; Ichiro Nakagawa; Yoshimitsu Abiko

  MICROBIAL PATHOGENESIS, Jan. 2012, Peer-reviewed

  
• Genotypic and PFGE/MLVA Analyses of Vibrio cholerae O1: Geographical Spread and Temporal Changes during the 2007-2010 Cholera Outbreaks in Thailand

  Kazuhisa Okada; Amonrattana Roobthaisong; Ichiro Nakagawa; Shigeyuki Hamada; Siriporn Chantaroj

  PLOS ONE, Jan. 2012, Peer-reviewed

  
• Cellular vacuolation induced by Clostridium perfringens epsilon-toxin

  Masahiro Nagahama; Yukari Itohayashi; Hideki Hara; Masahiro Higashihara; Yusuke Fukatani; Teruhisa Takagishi; Masataka Oda; Keiko Kobayashi; Ichiro Nakagawa; Jun Sakurai

  FEBS JOURNAL, Sep. 2011, Peer-reviewed

  
• The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

  Kazuhiko Nakano; Kazuya Hokamura; Naho Taniguchi; Koichiro Wada; Chiho Kudo; Ryota Nomura; Ayuchi Kojima; Shuhei Naka; Yoshinori Muranaka; Min Thura; Atsushi Nakajima; Katsuhiko Masuda; Ichiro Nakagawa; Pietro Speziale; Nobumitsu Shimada; Atsuo Amano; Yoshinori Kamisaki; Tokutaro Tanaka; Kazuo Umemura; Takashi Ooshima

  NATURE COMMUNICATIONS, Sep. 2011, Peer-reviewed

  
• Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification

  K Yamato; N Egawa; S Endo; K Ui-Tei; T Yamada; K Saigo; I Hyodo; T Kiyono; I Nakagawa

  CANCER GENE THERAPY, Aug. 2011, Peer-reviewed

  
• Complete Genome Sequence of the Bacterium Porphyromonas gingivalis TDC60, Which Causes Periodontal Disease

  Takayasu Watanabe; Fumito Maruyama; Takashi Nozawa; Akinobu Aoki; Soichiro Okano; Yasuko Shibata; Kenshiro Oshima; Ken Kurokawa; Masahira Hattori; Ichiro Nakagawa; Yoshimitsu Abiko

  JOURNAL OF BACTERIOLOGY, Aug. 2011, Peer-reviewed

  
• CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes

  Takashi Nozawa; Nayuta Furukawa; Chihiro Aikawa; Takayasu Watanabe; Bijaya Haobam; Ken Kurokawa; Fumito Maruyama; Ichiro Nakagawa

  PLOS ONE, May 2011, Peer-reviewed

  
• Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.

  S Endo; K Yamato; S Hirai; T Moriwaki; K Fukuda; H Suzuki; M Abei; I Nakagawa; I Hyodo

  Cancer Science, Mar. 2011, Peer-reviewed

  
• Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice.

  T Izumo; F Izumi; I Nakagawa; Y Kitagawa; H Shibata; Y Kiso

  Bioscience and Microflora, 2011, Peer-reviewed

  
• Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.

  A Sakurai; F Maruyama; J Funao; T Nozawa; C Aikawa; N Okahashi; S Shintani; S Hamada; T Ooshima; I Nakagawa

  Journal of Biological Chemistry, Jul. 2010, Peer-reviewed

  
• Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells

  Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Kohei Tsumoto; Shigeyuki Hamada; Ichiro Nakagawa

  CELLULAR MICROBIOLOGY, Jun. 2010, Peer-reviewed

  
• The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.

  A Sakurai; F Maruyama; J Funao; T Nozawa; C Aikawa; N Okahashi; S Shintani; S Hamada; T Ooshima; I Nakagawa

  J Biol Chem, May 2010, Peer-reviewed

  
• The dawning era of comprehensive transcriptome analysis in cellular microbiology

  Chihiro Aikawa; Fumito Maruyama; Ichiro Nakagawa

  FRONTIERS IN MICROBIOLOGY, 2010, Peer-reviewed

  
• An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.

  H Yamaguchi; I Nakagawa; A Yamamoto; A Amano; T Noda; T Yoshimori

  PLoS Pathogens, Nov. 2009, Peer-reviewed

  
• Listeria monocytogenes ActA-mediated escape from autophagic recognition

  Yuko Yoshikawa; Michinaga Ogawa; Torsten Hain; Mitsutaka Yoshida; Makoto Fukumatsu; Minsoo Kim; Hitomi Mimuro; Ichiro Nakagawa; Toru Yanagawa; Tetsuro Ishii; Akira Kakizuka; Elizabeth Sztul; Trinad Chakraborty; Chihiro Sasakawa

  NATURE CELL BIOLOGY, Oct. 2009, Peer-reviewed

  
• Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content

  Fumito Maruyama; Mitsuhiko Kobata; Ken Kurokawa; Keishin Nishida; Atsuo Sakurai; Kazuhiko Nakano; Ryota Nomura; Shigetada Kawabata; Takashi Ooshima; Kenta Nakai; Masahira Hattori; Shigeyuki Hamada; Ichiro Nakagawa

  BMC GENOMICS, Aug. 2009, Peer-reviewed

  
• Bacterial infection and autophagy.

  I Nakagawa

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jun. 2009, Peer-reviewed

  
• Bacterial genome analysis and its applications for infectious diseases.

  I Nakagawa

  Nihon rinsho. Japanese journal of clinical medicine, Jun. 2009, Peer-reviewed

  
• Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids

  Fumito Maruyama; Takashi Nozawa; Chihiro Aikawa; Atsuo Sakurai; Ichiro Nakagawa

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Apr. 2009, Peer-reviewed

  
• STREPTOCOCCUS-, SHIGELLA-, AND LISTERIA-INDUCED AUTOPHAGY

  Michinaga Ogawa; Ichiro Nakagawa; Yuko Yoshikawa; Torsten Hain; Trinad Chakraborty; Chihiro Sasakawa

  METHODS IN ENZYMOLOGY: AUTOPHAGY IN MAMMALIAN SYSTEMS, VOL 452, PT B, 2009, Peer-reviewed

  
• Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry

  Masako Ishimaru; Masuyoshi Yamada; Ichiro Nakagawa; Sumio Sugano

  JOURNAL OF BREATH RESEARCH, Sep. 2008, Peer-reviewed

  
• Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13

  Atsuo Sakurai; Nobuo Okahashi; Fumito Maruyama; Takashi Ooshima; Shigeyuki Hamada; Ichiro Nakagawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2008, Peer-reviewed

  
• Demonstration of Mother-to-Child Transmission of Streptococcus mutans Using Multilocus Sequence Typing

  J Lapirattanakul; K Nakano; R Nomura; S Hamada; I Nakagawa; T Ooshima

  CARIES RESEARCH, 2008, Peer-reviewed

  
• Role of Hrs in maturation of autophagosomes in mammalian cells

  Keiichi Tamai; Nobuyuki Tanaka; Atsuki Nara; Akitsugu Yamamoto; Ichiro Nakagawa; Tamotsu Yoshimori; Yoshiyuki Ueno; Tooru Shimosegawa; Kazuo Sugamura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed

  
• Streptococcus mutans clonal variation revealed by multilocus sequence typing

  Kazuhiko Nakano; Jinthana Lapirattanakul; Ryota Nomura; Hirotoshi Nemoto; Satu Alaluusua; Lisa Groenroos; Martti Vaara; Shigeyuki Hamada; Takashi Oshima; Ichiro Nakagawa

  JOURNAL OF CLINICAL MICROBIOLOGY, Aug. 2007, Peer-reviewed

  
• Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype

  Takahiro Kato; Shinji Kawai; Kazuhiko Nakano; Hiroaki Inaba; Masae Kuboniwa; Ichiro Nakagawa; Kayoko Tsuda; Hiroko Omori; Takashi Ooshima; Tamotsu Yoshimori; Atsuo Amano

  CELLULAR MICROBIOLOGY, Mar. 2007, Peer-reviewed

  
• Autophagy in innate immunity against intracellular bacteria

  Atsuo Amano; Ichiro Nakagawa; Tamotsu Yoshimori

  JOURNAL OF BIOCHEMISTRY, Aug. 2006, Peer-reviewed

  
• Host defense mechanism by autophagy.

  I Nakagawa; T Yoshimori

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2006, Peer-reviewed

  
• Genome sequence of an invasive M3 strain of Streptococcus pyogenes.

  I Nakagawa

  Nippon saikingaku zasshi. Japanese journal of bacteriology, Aug. 2006, Peer-reviewed

  
• Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae

  I Nakagawa; H Inaba; T Yamamura; T Kato; S Kawai; T Oshima; A Amano

  INFECTION AND IMMUNITY, Jul. 2006, Peer-reviewed

  
• Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells

  Akane Takemura; Ichiro Nakagawa; Shinji Kawai; Hiroaki Inaba; Takahiro Kato; Shigeyuki Hamada; Atsuo Amano

  JOURNAL OF PERIODONTOLOGY, May 2006, Peer-reviewed

  
• Intracellularly invading Streptococcus pyogenes is degraded by autophagic machinery

  I Nakagawa; S Hamada

  International Congress Series, Apr. 2006, Peer-reviewed

  
• Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome C release and cell death, independent of vacuolation

  E Yamasaki; A Wada; A Kumatori; I Nakagawa; J Funao; M Nakayama; J Hisatsune; M Kimura; J Moss; T Hirayama

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed

  
• Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae

  H Inaba; S Kawai; T Kato; I Nakagawa; A Amano

  INFECTION AND IMMUNITY, Jan. 2006, Peer-reviewed

  
• Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle

  K Tsuda; A Amano; K Umebayashi; H Inaba; I Nakagawa; Y Nakanishi; T Yoshimori

  CELL STRUCTURE AND FUNCTION, Dec. 2005, Peer-reviewed

  
• Host defense mechanism by autophagy.

  I Nakagawa

  Nippon saikingaku zasshi. Japanese journal of bacteriology, Aug. 2005, Peer-reviewed

  
• Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents

  K Tamura; K Nakano; R Nomura; S Miyake; I Nakagawa; A Amano; T Ooshima

  JOURNAL OF PERIODONTOLOGY, May 2005, Peer-reviewed

  
• Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases.

  S Hamada; I Nakagawa; S Kawabata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2005, Peer-reviewed

  
• Inhibitory effects of Porphyromonas gingivalis timbriae on interactions between extracellular matrix proteins and cellular integrins

  I Nakagawa; A Amano; H Inaba; S Kawai; S Hamada

  MICROBES AND INFECTION, Feb. 2005, Peer-reviewed

  
• Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans

  K Nakano; R Nomura; I Nakagawa; S Hamada; T Ooshima

  CARIES RESEARCH, 2005, Peer-reviewed

  
• Autophagy as an Innate Defense System against Invading Pathogenic Bacteria

  I Nakagawa

  Journal of Oral Biosciences, 2005, Peer-reviewed

  
• Autophagy defends cells against invading group a Streptococcus

  I Nakagawa; A Amano; N Mizushima; A Yamamoto; H Yamaguchi; T Kamimoto; J Nara; J Funao; M Nakata; K Tsuda; S Hamada; T Yoshimori

  SCIENCE, Nov. 2004, Peer-reviewed

  
• Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains

  K Nakano; R Nomura; N Shimizu; I Nakagawa; S Hamada; T Ooshima

  JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 2004, Peer-reviewed

  
• Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells

  I Nakagawa; M Nakata; S Kawabata; S Hamada

  CELLULAR MICROBIOLOGY, Oct. 2004, Peer-reviewed

  
• Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model

  K Nakano; M Kuboniwa; I Nakagawa; T Yamamura; R Nomura; N Okahashi; T Ooshima; A Amano

  ORAL MICROBIOLOGY AND IMMUNOLOGY, Jun. 2004, Peer-reviewed

  
• Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis

  A Amano; I Nakagawa; N Okahashi; N Hamada

  JOURNAL OF PERIODONTAL RESEARCH, Apr. 2004, Peer-reviewed

  
• Porphyromonas gingivalis induces receptor activator of NF-kappa B ligand expression in osteoblasts through the activator protein 1 pathway

  N Okahashi; H Inaba; I Nakagawa; T Yamamura; M Kuboniwa; K Nakayama; S Hamada; A Amano

  INFECTION AND IMMUNITY, Mar. 2004, Peer-reviewed

  
• A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice

  S Okamoto; S Kawabata; I Nakagawa; Y Okuno; T Goto; K Sano; S Hamada

  OPTIONS FOR THE CONTROL OF INFLUENZA V, 2004, Peer-reviewed

  
• Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity

  K Nakano; R Nomura; I Nakagawa; S Hamada; T Ooshima

  JOURNAL OF CLINICAL MICROBIOLOGY, Jan. 2004, Peer-reviewed

  
• Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappa B ligand

  A Sakurai; N Okahashi; I Nakagawa; S Kawabata; A Amano; T Ooshima; S Hamada

  INFECTION AND IMMUNITY, Oct. 2003, Peer-reviewed

  
• Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution

  I Nakagawa; K Kurokawa; A Yamashita; M Nakata; Y Tomiyasu; N Okahashi; S Kawabata; K Yamazaki; T Shiba; T Yasunaga; H Hayashi; M Hattori; S Hamada

  GENOME RESEARCH, Jun. 2003, Peer-reviewed

  
• Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice

  S Okamoto; S Kawabata; I Nakagawa; Y Okuno; T Goto; K Sano; S Hamada

  JOURNAL OF VIROLOGY, Apr. 2003, Peer-reviewed

  
• Infection by Streptococcus pyogenes induces the receptor activator of NF-kappa B ligand expression in mouse osteoblastic cells

  N Okahashi; A Sakurai; I Nakagawa; T Fujiwara; S Kawabata; A Amano; S Hamada

  INFECTION AND IMMUNITY, Feb. 2003, Peer-reviewed

  
• Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis

  I Nakagawa; A Amano; Y Ohara-Nemoto; N Endoh; I Morisaki; S Kimura; S Kawabata; S Hamada

  JOURNAL OF PERIODONTAL RESEARCH, Dec. 2002, Peer-reviewed

  
• Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients

  Y Terao; S Kawabata; M Nakata; I Nakagawa; S Hamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed

  
• A novel, anchorless streptococcal surface protein that binds to human immunoglobulins

  S Kawabata; Y Tamura; J Murakami; Y Terao; I Nakagawa; S Hamada

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2002, Peer-reviewed

  
• Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice

  I Nakagawa; M Nakata; T Yamamura; S Wakisaka; S Kawabata; S Hamada

  MICROBIAL PATHOGENESIS, Aug. 2002, Peer-reviewed

  
• Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9

  J Murakami; S Kawabata; Y Terao; K Kikuchi; K Totsuka; A Tamaru; C Katsukawa; K Moriya; I Nakagawa; I Morisaki; S Hamada

  EPIDEMIOLOGY AND INFECTION, Jun. 2002, Peer-reviewed

  
• Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: Analysis of strains isolated from human blood

  K Nakano; M Matsumura; M Kawaguchi; T Fujiwara; S Sobue; I Nakagawa; S Hamada; T Ooshima

  JOURNAL OF DENTAL RESEARCH, Jun. 2002, Peer-reviewed

  
• Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells

  Y Terao; S Kawabata; E Kunitomo; I Nakagawa; S Hamada

  INFECTION AND IMMUNITY, Feb. 2002, Peer-reviewed

  
• Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells

  I Nakagawa; A Amano; M Kuboniwa; T Nakamura; S Kawabata; S Hamada

  INFECTION AND IMMUNITY, Jan. 2002, Peer-reviewed

  
• Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells

  S Okamoto; S Kawabata; I Nakagawa; S Hamada

  INFECTION AND IMMUNITY, Nov. 2001, Peer-reviewed

  
• Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator

  Y Terao; S Kawabata; E Kunitomo; J Murakami; I Nakagawa; S Hamada

  MOLECULAR MICROBIOLOGY, Oct. 2001, Peer-reviewed

  
• Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia

  T Fujiwara; K Nakano; M Kawaguchi; T Ooshima; S Sobue; S Kawabata; I Nakagawa; S Hamada

  EUROPEAN JOURNAL OF ORAL SCIENCES, Oct. 2001, Peer-reviewed

  
• Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells

  I Nakagawa; M Nakata; S Kawabata; S Hamada

  CELLULAR MICROBIOLOGY, Jun. 2001, Peer-reviewed

  
• Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection

  M Kuboniwa; A Amano; S Shizukuishi; I Nakagawa; S Hamada

  INFECTION AND IMMUNITY, May 2001, Peer-reviewed

  
• Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress

  A Amano; T Premaraj; M Kuboniwa; I Nakagawa; S Shizukuishi; I Morisaki; S Hamada

  ORAL MICROBIOLOGY AND IMMUNOLOGY, Apr. 2001, Peer-reviewed

  
• Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome

  A Amano; T Kishima; S Akiyama; I Nakagawa; S Hamada; I Morisaki

  JOURNAL OF PERIODONTOLOGY, Mar. 2001, Peer-reviewed

  
• Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice

  S Kawabata; E Kunitomo; Y Terao; I Nakagawa; K Kikuchi; KI Totsuka; S Hamada

  INFECTION AND IMMUNITY, Feb. 2001, Peer-reviewed

  
• Molecular cloning, sequence, and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene.

  S Kawabata; Y Terao; I Nakagawa; S Hamada

  Oral Microbiology and Immunology, Dec. 2000, Peer-reviewed

  
• Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status

  A Amano; M Kuboniwa; I Nakagawa; S Akiyama; I Morisaki; S Hamada

  JOURNAL OF DENTAL RESEARCH, Sep. 2000, Peer-reviewed

  
• Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene

  I Nakagawa; A Amano; RK Kimura; T Nakamura; S Kawabata; S Hamada

  JOURNAL OF CLINICAL MICROBIOLOGY, May 2000, Peer-reviewed

  
• CD14-dependent and independent pathways in lipopolysaccharide-induced activation of a murine B-cell line, CH12.LX

  S Kimura; T Tamamura; I Nakagawa; T Koga; T Fujiwara; S Hamada

  SCANDINAVIAN JOURNAL OF IMMUNOLOGY, Apr. 2000, Peer-reviewed

  
• Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice

  S Kawabata; Y Terao; T Fujiwara; I Nakagawa; S Hamada

  INFECTION AND IMMUNITY, Nov. 1999, Peer-reviewed

  
• Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells

  I Nakagawa; M Nakata; S Kawabata; S Hamada

  MOLECULAR MICROBIOLOGY, Sep. 1999, Peer-reviewed

  
• Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis

  M Kontani; A Amano; T Nakamura; I Nakagawa; S Kawabata; S Hamada

  INFECTION AND IMMUNITY, Sep. 1999, Peer-reviewed

  
• Capsular hyaluronic acid of Group A Streptococci hampers their invasion into human pharyngeal epithelial cells

  S Kawabata; H Kuwata; I Nakagawa; S Morimatsu; K Sano; S Hamada

  MICROBIAL PATHOGENESIS, Aug. 1999, Peer-reviewed

  
• Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins

  T Nakamura; A Amano; I Nakagawa; S Hamada

  FEMS MICROBIOLOGY LETTERS, Jun. 1999, Peer-reviewed

  
• Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: Kinetic analyses based on surface plasmon resonance

  A Amano; T Nakamura; S Kimura; I Morisaki; I Nakagawa; S Kawabata; S Hamada

  INFECTION AND IMMUNITY, May 1999, Peer-reviewed

  
• Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients

  A Amano; I Nakagawa; K Kataoka; I Morisaki; S Hamada

  JOURNAL OF CLINICAL MICROBIOLOGY, May 1999, Peer-reviewed

  
• Studying initial phase of biofllm formation: Molecular interaction of host proteins and bacterial surface components

  A Amano; I Nakagawa; S Hamada

  Methods in Enzymology, 1999, Peer-reviewed

  
• Studying initial phase of biofilm formation: Molecular interaction of host proteins and bacterial surface components

  A Amano; I Nakagawa; S Hamada

  BIOFILMS, 1999, Peer-reviewed

  
• Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor

  A Takemura; N Matsuda; S Kimura; T Fujiwara; I Nakagawa; S Hamada

  JOURNAL OF PERIODONTAL RESEARCH, Oct. 1998, Peer-reviewed

  
• The importance of fimbriae in the virulence and ecology of some oral bacteria

  S Hamada; A Amano; S Kimura; I Nakagawa; S Kawabata; I Morisaki

  ORAL MICROBIOLOGY AND IMMUNOLOGY, Jun. 1998, Peer-reviewed

  
• Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease

  M Kontani; S Kimura; I Nakagawa; S Hamada

  MOLECULAR MICROBIOLOGY, Jun. 1997, Peer-reviewed

  
• Role of alpha beta T cells and gamma delta T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption

  I Takahashi; I Nakagawa; L Xu; S Hamada

  JOURNAL OF PERIODONTAL RESEARCH, Nov. 1996, Peer-reviewed

  
• Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches

  I Nakagawa; I Takahashi; H Kiyono; McGhee, JR; S Hamada

  JOURNAL OF INFECTIOUS DISEASES, Jun. 1996, Peer-reviewed

  
• Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin

  I Takahashi; M Marinaro; H Kiyono; RJ Jackson; I Nakagawa; K Fujihashi; S Hamada; JD Clements; KL Bost; McGhee, JR

  JOURNAL OF INFECTIOUS DISEASES, Mar. 1996, Peer-reviewed

  
• IL-12 RESCUES GALACTOSAMINE-LOADED MICE FROM LETHAL SHOCK TRIGGERED BY STAPHYLOCOCCAL-ENTEROTOXIN

  I TAKAHASHI; I NAKAGAWA; LH XU; S HAMADA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1995, Peer-reviewed

  
• MUCOSAL T-CELLS INDUCE SYSTEMIC ANERGY FOR ORAL TOLERANCE

  I TAKAHASHI; I NAKAGAWA; H KIYONO; MCGHEE, JR; JD CLEMENTS; S HAMADA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1995, Peer-reviewed

  
• INCONSISTENCY BETWEEN THE FIMBRILIN GENE AND THE ANTIGENICITY OF LIPOPOLYSACCHARIDES IN SELECTED STRAINS OF PORPHYROMONAS-GINGIVALIS

  T FUJIWARA; I NAKAGAWA; S MORISHIMA; I TAKAHASHI; S HAMADA

  FEMS MICROBIOLOGY LETTERS, Dec. 1994, Peer-reviewed

  
• MOLECULAR AND IMMUNOLOGICAL CHARACTERIZATION OF THE FIMBRIAE OF PORPHYROMONAS-GINGIVALIS

  S HAMADA; T FUJIWARA; S MORISHIMA; I TAKAHASHI; I NAKAGAWA; S KIMURA; T OGAWA

  MICROBIOLOGY AND IMMUNOLOGY, 1994, Peer-reviewed

  
• LPS OF ORAL BACTEROIDES SPECIES - GENERAL-PROPERTIES AND INDUCTION OF CYTOKINES IN HUMAN GINGIVAL FIBROBLAST-CULTURES

  S HAMADA; H TAKADA; J MIHARA; I NAKAGAWA; T FUJIWARA

  CELLULAR AND MOLECULAR ASPECTS OF ENDOTOXIN REACTIONS, 1990, Peer-reviewed

  
• ミコバクテリア症の定量的細菌リスク評価のための用量依存応答モデルの開発(Development of dose-response models for quantitative microbial risk assessment of mycobacteriosis)

  伊藤 寿宏; 大屋 賢司; 岩本 朋忠; 西内 由紀子; 中川 一路; 丸山 史人

  日本細菌学雑誌, Feb. 2018

  
• 豚レンサ球菌(Streptococcus suis)感染ルート解明のための養豚場内細菌叢調査

  Kim Hyunjung; 新井 沙倉; 村瀬 一典; 渡辺 孝康; 黒木 香澄; 丸山 史人; 遠矢 真理; 鈴木 詠律子; 竹下 奈知子; 中川 一路; 大澤 朗; 関崎 勉

  日本細菌学雑誌, Feb. 2018

  
• Streptococcus suisのヒト及びブタ細胞における細胞毒性およびオートファジー誘導に関する検討

  黒木 香澄; 野澤 孝志; 渡辺 孝康; Kim Hyunjung; 鈴木 詠律子; 中川 一路; 関崎 勉

  日本細菌学雑誌, Feb. 2018

  
• 次世代シーケンサーを用いたBCG Tokyo 172のシードロットおよび市販ロットにおけるヘテロ変異検出

  和田 崇之; 岩本 朋忠; 前田 伸司; 山本 太郎; 山本 三郎; 大原 直也; 中川 一路; 丸山 史人

  結核, Mar. 2016

  
• 次世代シーケンサーによるBCGワクチンのシードロットと市販ロットにおけるヘテロ変異の検出

  和田 崇之; 丸山 史人; 岩本 朋忠; 山本 太郎; 中川 一路; 山本 三郎; 大原 直也

  日本細菌学雑誌, Feb. 2016

  
• 微生物学の進歩 オートファジーによる防御システム：細胞内の細菌排除機構

  中川 一路

  日本細菌学雑誌, 2005

  

Misc.

• インプラント周囲炎・歯周炎罹患部位で活性を有する細菌群集比較を通じた周囲炎原因候補種の選定

  芝 多佳彦; 竹内 康雄; 中川 一路; 和泉 雄一

  口腔病学会雑誌, Mar. 2014

  
• 豚レンサ球菌は遺伝的系統により特徴的なDNA侵入防御機構遺伝子を有する

  大倉正稔; 野澤孝志; 渡辺孝康; 村瀬一典; 中川一路; 高松大輔; 大崎慎人; 関崎勉; GOTTSCHALK Marcelo; 浜田茂幸; 丸山史人

  農研機構動物衛生研究部門成果情報(Web), 2017

  
• HLAクラスI認識受容体群LILRの新展開 病原微生物によって壊された抗体を認識する生体防御機構

  平安 恒幸; 齋藤 史路; 末永 忠広; 信田 京子; 荒瀬 規子; 及川 敬太; 山岡 俊文; 室田 浩之; 知花 博治; 中川 一路; 久堀 智子; 永井 宏樹; 中丸 裕爾; 片山 一朗; Colonna Marco; 荒瀬 尚

  MHC: Major Histocompatibility Complex, Oct. 2016

  
• 類似した臨床症状を呈する複合感染症から紐解く恒常性維持機構

  芝多佳彦; 渡辺孝康; 小柳達郎; 丸山緑子; 竹内康雄; 丸山史人; 中川一路; 和泉雄一

  日本歯周病学会会誌(Web), 18 Apr. 2016

  
• ゲノム解析から明らかとなったStreptococcus suisにおける曖昧な種の境界及び進化の鍵となるスポット

  大倉正稔; 野澤孝志; 渡辺孝康; 中川一路; 高松大輔; 大崎慎人; 関崎勉; 浜田茂幸; 丸山史人

  日本細菌学雑誌, 2015

  
• 豚心内膜炎病変部に共存したStreptococcus suis無莢膜株および有莢膜株の遺伝的近縁性とゲノム変異についての解析

  遠矢真理; 新井沙倉; 丸山史人; 渡辺孝康; 大田篤; 大倉正稔; 高松大輔; 高松大輔; 大崎慎人; 中川一路; 関崎勉

  日本獣医学会学術集会講演要旨集, 2015

  
• 豚レンサ球菌莢膜糖鎖合成遺伝子領域を標的とした型別法の開発と利用

  大倉正稔; 大崎慎人; 関崎勉; 丸山史人; 野澤孝志; 中川一路; 浜田茂幸; 高松大輔; 高松大輔

  日本細菌学雑誌, 2014

  
• 豚レンサ球菌の血清型を推定できる遺伝子タイピング法の開発

  大倉正稔; LACHANCE Claude; 大崎慎人; 関崎勉; 丸山史人; 野澤孝志; 中川一路; 浜田茂幸; ROSSIGNOL Celine; GOTTSCHALK Marcelo; 高松大輔

  農研機構動物衛生研究所成果情報(Web), 2014

  
• 豚レンサ球菌全35血清型の莢膜多糖合成関連遺伝子群の同定

  大倉正稔; 丸山史人; 野澤孝志; 中川一路; 大崎慎人; 関崎勉; GOTTSCHALK Marcelo; 熊谷由美; 浜田茂幸; 高松大輔

  農研機構動物衛生研究所成果情報(Web), 2013

  
• レンサ球菌の線毛構成蛋白質をもとにした自発的に還元環境下で重合する蛋白質の設計

  松長遼; 谷中冴子; 中川一路; 津本浩平; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2012

  
• 還元環境下で自発的な共有結合形成により重合する蛋白質の開発

  松長遼; 谷中冴子; 中川一路; 津本浩平

  日本化学会講演予稿集, 2012

  
• レンサ球菌由来線毛構成蛋白質のin vitro重合

  松長遼; 谷中冴子; 中川一路; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2010

  
• Streptococcus mutans における Multilocus sequence typing 法の確立

  ジンタナー ラピラッタナクン; 仲野 和彦; 中川 一路; 浜田 茂幸; 大嶋 隆

  日本細菌学雑誌, 25 Feb. 2007

  
• ストレプトリジンOによるA群レンサ球菌の細胞質脱出機構の解析

  船尾 純子; 桜井 敦朗; 大嶋 隆; 中川 一路

  日本細菌学雑誌, 25 Feb. 2007

  
• A群レンサ球菌感染によりオートファジーを誘導するNLRファミリー遺伝子の機能解析

  桜井 敦朗; 丸山 史人; 船尾 純子; 浜田 茂幸; 中川 一路

  日本細菌学雑誌, 25 Feb. 2007

  
• 劇症型感染症をひき起こすA群レンサ球菌のゲノム解析と病原性因子

  浜田 茂幸; 中川 一路; 川端 重忠

  蛋白質核酸酵素, Mar. 2005

  
• 感染症とゲノム(5)A群溶血性レンサ球菌のゲノム解析

  中川 一路; 浜田 茂幸

  ゲノム医学, Aug. 2004

  
• 唾液タンパクを介したA群レンサ球菌の細胞付着機構の解析

  川端 重忠; 村上 旬平; 寺尾 豊; 中川 一路; 浜田 茂幸

  歯科基礎医学会雑誌, 20 Sep. 2002

  
• 細胞外マトリックスタンパクとレセプターインテグリンとの結合におけるP.gingivalis線毛の影響

  中川 一路; 中村 好孝; 天野 敦雄; 浜田 茂幸

  歯科基礎医学会雑誌, 20 Aug. 2001

  
• Distribution and Molecular Characterization of Porphyromonas gingivalis Carrying a New Type of fimA Gene

  Nakagawa Ichiro

  Japanese journal of oral biology, 20 Jun. 2001

  
• 一般歯科診療所来院患者におけるメチシリン耐性ブドウ球菌の分布とその性状

  椋木 修; 中川 一路; 川端 重忠; 浜田 茂幸

  歯科基礎医学会雑誌, 30 Aug. 2000

  
• Streptococcus mutans pac遺伝子の5'上流域に関する分子生物学的解析

  寺尾 豊; 川端 重忠; 村上 旬平; 中川 一路; 浜田 茂幸

  歯科基礎医学会雑誌, 30 Aug. 2000

  
• フィブロネクチンとPorphyromonas gingivalis線毛の結合部位の解析

  Premaraj Thyagaseely; 中川 一路; 天野 敦雄; 中村 好孝; 川端 重忠; 浜田 茂幸

  歯科基礎医学会雑誌, 30 Aug. 2000

  
• マウスでのkgpDNAワクチンPorphyromonas gingivalis感染防御効果

  久保庭雅恵; 天野敦雄; 中川一路; 雫石聡; 浜田茂幸

  日本細菌学雑誌, 2000

  
• Streptococcus pyogenes FBP54 DNA ワクチン接種によるマウスの免疫応答

  寺尾 豊; 川端 重忠; 西川 弘一; 国友 栄治; 中川 一路; 浜田 茂幸

  歯科基礎医学会雑誌, 20 Aug. 1999

  
• 新型(V型)の線毛遺伝子(fimA)を有するP. gingivalisの分離

  中川 一路; 天野 敦雄; 中村 好孝; 川端 重忠; 浜田 茂幸

  歯科基礎医学会雑誌, 20 Aug. 1999

  
• デンタルインプラントの口腔内露出後に生じる周囲細菌叢の経時変化

  下岸 将博; 渡辺 孝康; 柴崎 真樹; 中野 善夫; 春日井 昇平; 中川 一路

  日本細菌学雑誌, Jan. 2020, Peer-reviewed

  
• 16S rRNA gene analysis for dental plaque microbiota of cleft lip and/or palate patients

  Muramoto K; Watanabe T; Shiba T; Funahashi K; Ogawa T; Nakagawa I; Moriyama K

  Orthod Waves Jpn Ed, Mar. 2019, Peer-reviewed

  
• 潜在期結核菌抗原の精製と感染診断への応用

  大原 由貴子; 尾関 百合子; 立石 善隆; 西山 晃史; 山本 三郎; 中川 一路; 松本 壮吉

  日本細菌学雑誌, Feb. 2018

  
• 口唇口蓋裂患者におけるデンタルプラーク細菌叢のメタトランスクリプトーム解析

  舩橋健太; 渡辺孝康; 芝多佳彦; 村本慶子; 小川卓也; 中川一路; 竹内康雄; 和泉雄一; 森山啓司

  Journal of Oral Biosciences Supplement (Web), Sep. 2017

  
• インプラント周囲炎と歯周炎の細菌学的な違いを科学する

  芝多佳彦; 竹内康雄; 渡辺孝康; 小柳達郎; 丸山緑子; 加地博一; 村瀬一典; 丸山史人; 中川一路; 和泉雄一

  歯界展望, May 2017

  
• 潜在期結核菌抗原の精製と感染診断への応用(Significance of the histone-like protein with the native structure for diagnosis of asymptomatic tuberculosis)

  西田 由貴子; 尾関 百合子; 立石 善隆; 西山 晃史; 山本 三郎; 中川 一路; 松本 壮吉

  日本細菌学雑誌, Feb. 2017

  
• 細菌叢遺伝子発現解析によるインプラント周囲炎および歯周炎の疾患特異的な細菌ネットワーク

  渡辺孝康; 芝多佳彦; 加地博一; 村瀬一典; 竹内康雄; 丸山史人; 和泉雄一; 中川一路

  日本細菌学雑誌(Web), Feb. 2017

  
• 種内相互組み換えによって促進される鳥型結核菌の地域適応

  矢野大和; 丸山史人; 西内由紀子; 中川一路; 中島千絵; 鈴木定彦; 岩本朋忠

  日本ゲノム微生物学会年会要旨集, 2017

  
• HLAクラスI認識受容体群LILRの新展開 病原微生物によって壊された抗体を認識する生体防御機構

  平安 恒幸; 齋藤 史路; 末永 忠広; 信田 京子; 荒瀬 規子; 及川 敬太; 山岡 俊文; 室田 浩之; 知花 博治; 中川 一路; 久堀 智子; 永井 宏樹; 中丸 裕爾; 片山 一朗; Colonna Marco; 荒瀬 尚

  MHC: Major Histocompatibility Complex, Oct. 2016

  
• インプラント周囲炎と歯周炎における細菌叢メタトランスクリプトーム解析

  渡辺 孝康; 芝 多佳彦; 加地 博一; 竹内 康雄; 丸山 史人; 和泉 雄一; 中川 一路

  Journal of Oral Biosciences Supplement, Sep. 2016

  
• 類似した臨床症状を呈する複合感染症から紐解く恒常性維持機構

  芝 多佳彦; 渡辺 孝康; 小柳 達郎; 丸山 緑子; 竹内 康雄; 丸山 史人; 中川 一路; 和泉 雄一

  日本歯周病学会会誌, Apr. 2016

  
• Highlighting genome evolution by a novel acquired immunity system in prokaryotes

  Watanabe T; Murase K; Nakagawa I; Maruyama F

  Antibiotics & Chemotherapy, Nov. 2015

  
• CRISPR/Cas システム： 微生物における新規機能とゲノム編集適用例

  相川知宏; 丸山史人; 中川一路

  日本乳酸菌学会誌, 2015

  
• インプラント周囲炎および歯周炎罹患部位の細菌群集比較を通じた周囲炎原因候補種と機能遺伝子の選定

  芝 多佳彦; 丸山 史人; 竹内 康雄; 渡辺 孝康; 小柳 達郎; 和泉 雄一; 中川 一路

  日本細菌学雑誌, Feb. 2014

  
• 8-Nitro-cGMP: an endogenous regulator of antibacterial autophagy

  Ito Chiaki; Saito Yohei; Nozawa Takashi; Fujii Shigemoto; Hashimoto Ryota; Sawa Tomohiro; Akaike Takaaki; Nakagawa Ichiro; Hirokazu Arimoto

  Symposium on the Chemistry of Natural Products, symposium papers, 2014

  
• 原核生物の新規な獲得免疫機構CRISPR/Casシステム

  渡辺孝康; 中川一路; 丸山史人

  化学と生物, Jul. 2013

  
• 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】オートファジー-リソソーム/液胞系 オードファジーの生理的役割 感染防御機構としてのオートファジー

  中川 一路; 吉森 保

  蛋白質・核酸・酵素, Aug. 2006

  
• オートファジーが病原性細菌を殺す

  中川 一路; 吉森 保

  細胞工学, Dec. 2004

  
• Effect of gingipain on RANKL expression by osteoblasts

  N. Okahashi; M. Kuboniwa; I. Nakagawa; K. Nakayama; A. Amano

  Jpn. J. Bacteriol. 59:85, Apr. 2004

  
• Virulence of P-gingivalis strains with distinct fimA genotypes.

  K. Nakano; I. Nakagawa; M. Kuboniwa; N. Okahashi; T. Ooshima; A. Amano

  JOURNAL OF DENTAL RESEARCH, Jun. 2003

  
• RANKL expression of mouse osteoblasts infected with P. gingivalis

  N. Okahashi; H. Inaba; I. Nakagawa; T. Yamamura; A. Amano; S. Hamada

  Jpn. J. Bacteriol. 58:283, Apr. 2003

  
• Induction of septic arthritis by group A streptococcus

  A. Sakurai; N. Okahashi; I. Nakagawa; S. Kawabata; T. Ooshima; S. Hamada

  Jpn. J. Bacteriol. 57:, Apr. 2002

  
• RANKL expression on osteoblasts infected with group A strepcotoccus

  N. Okahashi; A. Sakurai; I. Nakagawa; T. Fujiwara; S. Kawabata; A. Amano; S. Hamada

  Jpn. J. Bacteriol. 57:, Mar. 2002

  
• kgpDNAワクチンにより誘導される特異抗体はP. gingivalisの鉄獲得を阻害する

  久保庭 雅恵; 天野 敦雄; 中川 一路; 浜田 茂幸

  歯科基礎医学会雑誌, 30 Aug. 2000

  
• A群レンサ球菌の咽頭部上皮細胞HEp‐2への付着・侵入とヒアルロン酸の関与 第45回大阪大学歯学会総会

  桑田啓貴; 川端重忠; 中川一路; 浜田茂幸

  大阪大学歯学雑誌, 10 Aug. 1999

  
• GAMMA-DELTA-T-CELLS SUSTAIN INFECTIOUS IMMUNITY TO PERIODONTAL BACTERIA IN MICE

  TAKAHASHI, I; NAKAGAWA, I; A DEGUCHI; S HAMADA

  JOURNAL OF DENTAL RESEARCH, 1995

  
• Compositional change of peri-implant microbiota after the implant placement

  下岸将博; 渡辺孝康; 柴崎真樹; 中野善夫; 春日井昇平; 中川一路

  日本細菌学雑誌(Web), 2020

  
• 化膿連鎖球菌の金属獲得蛋白質MtsAに対する機能阻害剤の探索

  竹内美結; 中木戸誠; 長門石曉; 河出来時; 相川知宏; 中川一路; 津本浩平; 津本浩平; 津本浩平

  日本生化学会大会(Web), 2020

  
• Strategy to develop small molecule and antibody-based inhibitors relying on biophysical techniques

  中木戸誠; 相川知宏; 長門石曉; 妹尾暁暢; 竹内美結; 星野将人; 下村拓矢; CAAVEIRO Jose M. M.; 中川一路; 津本浩平; 津本浩平

  日本細菌学雑誌(Web), 2020

  
• 分子間相互作用阻害に基づく菌種特異的な増殖阻害剤の開発

  中川一路; 相川知宏; 妹尾暁暢; 中木戸誠; 長門石暁; 津本浩平; 津本浩平

  日本生化学会大会(Web), 2019

  
• Porphyromonas属ゲノムにおけるCRISPRと免疫対象の探索

  渡辺孝康; 柴崎真樹; 関崎勉; 中川一路

  日本細菌学雑誌(Web), 2018

  
• 時空間的に異なる猩紅熱の流行より採取されたemm12型A群レンサ球菌株における遺伝子変異の探索

  柴崎真樹; 渡辺孝康; 春日井昇平; 中川一路

  日本細菌学雑誌(Web), 2018

  
• 化膿連鎖球菌の鉄獲得機構を阻害する新規低分子・抗体の取得

  妹尾暁暢; 星野将人; 中木戸誠; 長門石曉; 長門石曉; 相川知宏; 中川一路; 津本浩平; 津本浩平

  日本生化学会大会(Web), 2018

  
• 病原性微生物における鉄獲得関連蛋白質の物理化学解析と新規抗菌剤の探索

  中木戸誠; 妹尾暁暢; VALENCIANO Sandra; 星野将人; 相川知宏; 長門石曉; 長門石曉; CAAVEIRO Jose; 中川一路; 津本浩平; 津本浩平

  日本生化学会大会(Web), 2018

  
• emm12型A群レンサ球菌のタンパク質コード領域における一塩基多型の分布

  柴崎真樹; 渡辺孝康; 中川一路; 春日井昇平

  Journal of Oral Biosciences Supplement (Web), 2017

  
• Porphyromonas属内におけるCRISPRと免疫対象の関係

  渡辺孝康; 柴崎真樹; 中川一路

  Journal of Oral Biosciences Supplement (Web), 2017

  
• Identification of novel inhibitor for Group A Streptococcus growth

  相川知宏; 星野将人; 長門石曉; 津本浩平; 中川一路

  日本細菌学雑誌(Web), 2017

  
• CRISPR-プロファージ相互作用解析から見出されたA群レンサ球菌のゲノム進化機構

  山田俊介; 柴崎真樹; 渡辺孝康; 相川知宏; 野澤孝志; 丸山史人; 中川一路

  日本細菌学雑誌, 2015

  
• P25-42 CRISPRを保有するバクテリオファージの系統学的普遍性(ポスター発表)

  渡辺 孝康; 野澤 孝志; 丸山 史人; 中川 一路

  日本微生物生態学会講演要旨集, 2014

  
• 細胞内寄生を介したA群連鎖球菌の多様化・進化機構の解明

  山田俊介; 柴崎真樹; 渡辺孝康; 丸山史人; 丸山史人; 中川一路

  日本ゲノム微生物学会年会要旨集, 2014

  
• PN-002 歯周病原細菌ゲノム情報から紐解く種の維持と共生機構(遺伝学・遺伝子伝播,ポスター発表)

  遠藤 亜希子; 渡辺 孝康; 丸山 史人; 和泉 雄一; 中川 一路

  日本微生物生態学会講演要旨集, 2013

  
• PB-063 養殖環境由来薬剤耐性伝達性プラスミドの比較解析(PB 遺伝子伝播,ポスター発表)

  野中 里佐; 丸山 史人; 小椋 義俊; 林 哲也; 中川 一路; 増田 道明

  日本微生物生態学会講演要旨集, 2011

  

Awards

• 20 Mar. 1998

  Japanese Sciety for Bacteriology, 黒屋奨励賞
• 15 Apr. 1998

  The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, The Young Scientists' Prize

External funds: Kakenhi

• 菌種特異的に進化した金属特異的レセプターに対する新規創薬基盤の開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  中川 一路

  From 01 Apr. 2022, To 31 Mar. 2024, Granted

  Ａ群レンサ球菌;金属レセプター;低分子化合物;抗体;感染防御;A群レンサ球菌;金属トランスポーター;ヘム獲得系;CDF排出トランスポーター;金属特異的レセプター;新規創薬;レンサ球菌;菌種特異性

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04809/
• Elucidation of Xenophagy Regulation by Bacterial Glycan Recognition

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49050:Bacteriology-related

  Kyoto University

  中川 一路

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ゼノファジー;Ａ群レンサ球菌;自然免疫;糖鎖認識;A群レンサ球菌;ユビキチン;認識;GBP1;ガレクチン３;TBK1;細菌感染

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02868/
• レンサ球菌高病原化変異株が分泌するaromatic-rich ペプチドの機能解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49050:Bacteriology-related

  National Center for Global Health and Medicine

  竹本 訓彦

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  高病原化変異;A群レンサ球菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07083/
• Search for Population Dynamics and Novel Epigenomic Regulations that Manipulate Bacterial Pathogenicity

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  Ichiro Nakagawa

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  A群レンサ球菌;遺伝子変異;ゼノファジー;病原性の変化;エピジェネティクス;高病原化;莢膜;メチル化酵素;メチル化;ポピュレーションダイナミクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19376/
• Clarification of virulence factor involved in the chronicity of osteomyelitis of the jaw

  Grant-in-Aid for Scientific Research (C)

  Basic Section 57060:Surgical dentistry-related

  Tokyo Medical and Dental University

  道 泰之

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  複合感染症;顎骨骨髄炎;メタ16S解析;ネットワーク解析;細菌叢解析;メタトランスクリプトーム解析;細菌叢;プロテオーム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10112/
• 皮膚微小環境において極小マイクロバイオームが果たす役割の解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53050:Dermatology-related

  Kyoto University

  中島 沙恵子

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  皮膚マイクロバイオーム;極小マイクロバイオーム;レーザーキャプチャーマイクロダイセクション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08669/
• Nutrient Immunityに対抗する細菌の金属輸送系の進化と機能解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  中川 一路

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  -A群レンサ球菌;金属j獲得レセプター;AdcA-II;亜鉛;細菌;適応;金属獲得;創薬ターゲット;nutrient immunity;A群連鎖球菌;金属輸送系;AdcA;マンガン;鉄

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05504/
• Elucidation of the Rab regulatory network that induces bacterial species-specific xenophagy

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49050:Bacteriology-related

  Kyoto University

  Ichiro Nakagawa

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  ゼノファジー;A群レンサ球菌;ユビキチン化;Fboxプロテイン;菌体表層糖鎖;GAC;ガレクチン;-A群レンサ球菌;SLO;Nga;ゴルジ体;黄色ブドウ球菌;RabGAP;RabGEF;オートファジー;上皮間接着;TBC1D9;細胞内カルシウム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03471/
• Conprehensive functional analyses of cell-wall proteins of Streptococcus suis

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42020:Veterinary medical science-related

  Kyoto University;The University of Tokyo

  TSUTOMU SEKIZAKI

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  豚レンサ球菌;細胞壁タンパク質;遺伝子破壊株;網羅的機能解析;病原性;細胞壁結合蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03126/
• Development of a new diagnostic and therapeutic platform for swine Streptococcus infections to prevent the emergence of drug-resistant strains.

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 42:Veterinary medical science, animal science, and related fields

  Kyoto University

  Ichiro Nakagawa

  From 09 Oct. 2018, To 31 Mar. 2022, Project Closed

  ブタレンサ球菌;抗体;人工抗体;抗原同定;タイ;ベトナム;Streptocuccus suis;強毒株;菌体表層分子;ワクチン抗原;抗原;ブタ血清;単分子抗体;質量分析;豚レンサ球菌;血清;IgG;薬剤耐性;ファージディスプレイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0193/
• Spatio-temporal surveillance of peri-implant microbiota

  Grant-in-Aid for Scientific Research (C)

  Basic Section 57040:Regenerative dentistry and dental engineering-related

  Tokyo Medical and Dental University

  Masahiro Shimogishi

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  歯科インプラント;細菌;インプラント;感染症;細菌叢

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09618/
• Development of species-specific anti-bacterial therapeutic agents based on molecular interaction

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  ICHIRO NAKAGAWA

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  A群レンサ球菌;鉄獲得系;Shr;ヘム鉄;増殖阻害薬;低分子化合物;スクリーニング;抗体;鉄取り込み;単分子抗体;機能阻害;タンパク質相互作用;細菌感染症;菌種特異的増殖阻害剤;分子間相互作用;分子標的薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19552/
• Elucidation of pathogenic factors possessed by bacterial flora of Osteomyelitis of the jaw, and proposal of novel therapeutic strategies.

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  Yasuyuki Michi

  From 01 Apr. 2017, To 31 Mar. 2022, Project Closed

  顎骨骨髄炎;複合感染症;細菌叢解析;メタ16S解析;機能遺伝子予測;細菌叢;メタゲノム;メタトランスクリプトーム;メタゲノム解析;細菌性ネットワーク

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11827/
• Analysis of collaborative activities between the capsule-positive and capsule-negative Streptococcus suis in the induction of and escape from autophagy

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Tsutomu Sekizaki

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  豚レンサ球菌;オートファジー;莢膜;心内膜炎;感染症;細胞障害性;細胞侵入性;細胞壁タンパク質;オードファジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15037/
• Validation of microbial safety in drinking water in the world by comparative genomics of Vibrio cholerae

  Grant-in-Aid for Scientific Research (B)

  Hiroshima University;Kyoto University

  Fumito MARUYAMA

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  コレラ;比較ゲノム解析;薬剤耐性;ゲノム疫学;CRISPR;ゲノム;魚病;コレラ菌;海外;フィールド;比較ゲノム;ビブリオ;水圏;生態

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05830/
• Elucidation of genomic diversification in Group A Streptococci based on GWAS and epigenome

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  FUMITO MARUYAMA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  比較ゲノム;進化;多様性;細菌ゲノム;多様化;溶連菌;エピゲノム;GWAS;ゲノム解析;メチローム;トランスクリプトーム;病原性;A群レンサ球菌;ゲノム;細菌;微生物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05501/
• Regulation of xenophagy aginst Group A Streptococcus

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  ICHIRO NAKAGAWA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  A群レンサ球菌;オートファジー;Rab35;TDC1D10A;ゼノファジー;Rab30;フォスファチジルイノシトール4リン酸;細菌感染;ユビキチン化;Rabタンパク質;A群特異的糖鎖;ユビキチン;アダプター;糖鎖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05188/
• Development of DNA memory device using spacers in CRISPR

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Fumito Maruyama

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  CRISPR;レンサ球菌;比較ゲノム解析;A群レンサ球菌;進化;多様化;病原細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15675/
• Visualization of bacteria-induced autophagy by live-imaging.

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  ICHIRO NAKAGAWA

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  A群レンサ球菌;オートファジー;イメージング;Rabタンパク質;ゼノファジー;膜形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15130/
• Analysis of porcine oral flora dynamics for determining the main cause of developing swine streptococcosis

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  TSUTOMU SEKIZAKI

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  豚レンサ球菌;口腔内細菌叢;微生物動態;メタゲノム解析;感染症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02651/
• Elucidation of the pathogenesis of cleft palate and tooth devevelopment problmes using new molecular technology.

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Takashi Yamashiro

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  口蓋裂;Runx1;Cbfb;Stat3;Tgfb3;Lgr5;サービカルループ;ゲノム編集;歯学;バイオテクノロジー;発生・分化;口蓋;歯;遺伝子改変動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02577/
• Clarification of pathological condition of osteomyelitis of the jaw based on the analysis of microbiome network, and proposal of the optimal therapeutic strategy

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  Yasuyuki MICHI

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  複合感染症;顎骨骨髄炎;メタ16s解析;メタゲノム解析;メタ16S解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462997/
• A群レンサ球菌の感染細胞内でのファージを介したゲノムアダプテーション

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University;Tokyo Medical and Dental University

  中川 一路

  From 28 Jun. 2013, To 31 Mar. 2015, Project Closed

  A群レンサ球菌;ファージ;CRISPR;進化;ゲノム;溶原化

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25125708/
• Regulation and reconstruction of acquired memories in human microbiota

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University;Tokyo Medical and Dental University

  Fumito MARUYAMA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  バクテリオファージ;CRISPR;微生物生態学;細菌叢解析;外来因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670776/
• Development of a new therapeutic method by genome-editing

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University;Tokyo Medical and Dental University

  Ichiro NAKAGAWA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  Ａ群レンサ球菌;CRIPSR;TALEN;ZFN;増殖抑制;A群レンサ球菌;CRISPR;Cas9;ファージ;ゲノム編集;感染制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670775/
• Establishment of a new prediction medhods of epidemic strains in Group A Streptococcus by CRISPR typing.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;Tokyo Medical and Dental University

  ICHIRO NAKAGAWA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  A群レンサ球菌;emmタイピング;CRIPSR;レンサ球菌;ゲノム;莢膜;CRISPR;ブタレンサ球;スペーサー解析;流行予測;国際研究者交流;タイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25305013/
• Analysis of Atg5 dependent and independent autophagy and induction mechanism of inflammation during bacterial infection.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;Tokyo Medical and Dental University

  ICHIRO NAKAGAWA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  A群レンサ球菌;xenophagy;オートファジー;Rabタンパク質;炎症;Rab30;Rab9;Rab23;Rab17;認識分子;炎症誘導;Atg5

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293370/
• Analysis of microbiota and its function associated with peri-implantitis using next generation sequencing technology

  Grant-in-Aid for Young Scientists (B)

  Tokyo Medical and Dental University

  Yasuo TAKEUCHI

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  インプラント周囲炎;歯周病原細菌;次世代シークエンシング;polymicrobial disease;トランスクリプトーム;インプラント;歯周炎;細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792321/
• Novel functions of Runx genes as causal genes for ectodermal dysplasia

  Grant-in-Aid for Scientific Research (A)

  Osaka University;Okayama University

  Takashi Yamashiro

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  Runxシグナリング;上皮間葉相互作用;器官形成;Cbfb;Runx1;唾液腺;歯;皮膚付属器官;Ｃｂｆｂ;切歯;臼歯

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24249093/
• Maintenance mechanism of oral homeostasis revealed by fine scale analysis of microbiota

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  Fumito MARUYAMA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  細菌叢;新型シーケンサー;恒常性;口腔細菌叢;細菌ゲノム;高速シーケンサー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592032/
• The elucidation of molecular mechanisms of amelogenesis by epitherial-specific Runx knockout mouse

  Grant-in-Aid for Scientific Research (B)

  Tottori University;Okayama University

  Tadashi HONJO

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  Runx1, Cbfb;エナメル芽細胞;遺伝子改変動物;エナメル質;Runxシグナリング;Runx1;Cbvb;cbfb;runx1;Runx;Cbfb;歯原性上皮

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390390/
• The new paradigm to search the bioscientific mechanism of malocclusion

  Grant-in-Aid for Challenging Exploratory Research

  Okayama University

  Takashi YAMASHIRO

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  不正咬合;エピジェネティクス;分子機構;実験的歯の移動モデル;クロマチン;マイクロアレイ;実験的不正咬合モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659375/
• The possible role of autophagy in craniofacial development

  Grant-in-Aid for Scientific Research (B)

  Okayama University

  Takashi YAMASHIRO

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  オートファジー;口蓋の形成;口蓋突起;骨組織;ERストレス;ATG5;LC3;小胞体ストレス;口唇口蓋裂;骨形成;口蓋;顎顔面;骨格;骨芽細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390547/
• レンサ球菌属における種特異的ゲノム進化機構の解明

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  中川 一路

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  A群レンサ球菌;S.mutans;ファージ;進化;再構成;CRISPR;レンサ球菌;Streptococcus mutans;バクテリオファージ;グノム再構成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390487/
• 新規遺伝子獲得の可視化によるA群レンサ球菌の病原性発現機構の解析

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University;Nihon University

  浜田 茂幸

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  レンサ球菌;A群レンサ球菌;Streptococcus mutans;バクテリオファージ;CRISPR;ゲノム再構成;マイクロアレイ;タイリングアレイ;転写;GFP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20659286/
• Tiling array analysis of transcriptional regulators in genus Streptococcus

  Grant-in-Aid for Scientific Research (B)

  Nihon University

  Shigeyuki HAMADA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  レンサ球菌;マイクロアレイ;タイリングアレイ;遺伝子発現;A群レンサ球菌;non-coding RNA;転写調節;感染

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390468/
• Induction mechanism of Inflammation and autophagy by group A Streptococcus infection

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Ichiro NAKAGAWA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  A 群レンサ球菌;細胞内侵入性;菌体成分;炎症反応;オートファジー;A群レンサ球菌;炎症惹起;Nod1;Nod2;炎症;Nod like receptor;分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390125/
• Analysis of virulence factors in cariogenic bacteria for cardiovascular diseases

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Takashi OOSHIMA

  From 01 Apr. 2007, To 31 Mar. 2011, Project Closed

  Streptococcus mutans;う蝕;全身疾患;循環器疾患;コラーゲン結合タンパク;血清型;感染性心内膜炎;心臓弁;血小板凝集;疣贅;グルコシルトランスフェラーゼ;大動脈瘤;分子生物学;菌休表層タンパク;ゲノム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19209063/
• 細胞内侵入性細菌に対する細胞内認識システムとオートファジー誘導の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  中川 一路

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  オートファジー;A群レンサ球菌;炎症惹起;Nod1;Nod2;菌体成分;ペプチドグリカン;マイクロインジェクション;Nod like receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19041023/
• NODファミリー分子によるA群レンサ球菌の認識とオートファジー誘導の動態解析

  Grant-in-Aid for Exploratory Research

  Nihon University

  浜田 茂幸

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  A群レンサ球菌;オートファジー;Nod Like receptor;Nod2;グラム陽性菌;細胞壁;ペプチドグリカン;NODファミリー;アポトーシス;感染症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18659544/
• 細菌感染によるオートファジー誘導の分子機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  天野 敦雄

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  歯学;細菌;感染症;細胞・組織;シグナル伝達;オートファジー;A群レンサ球菌;細胞内侵入細菌;自然免疫システム;Nod-like receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18050018/
• Analysis of host defense system against pathogenic oral bacteria in oral epithelial cells by the intracellular PAMPs receptors

  Grant-in-Aid for Scientific Research (C)

  Tokyo University;Osaka University

  Ichiro NAKAGAWA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  A群レンサ球菌;オートファジー;菌体成分認識;miR-RNAi;ノックダウン;Nalp;NLRファミリー;P. gingivalis;侵入;エンドサイトーシス;インテグリン;ラフト, Group A Streptococcus;autophagy;recognition receptor;miR-RNAi;knockdown;Nalp

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591904/
• Analysis of the relationship of periodontal susceptibility to periodontal dicease with bactericidal activity against P. gingivalis by periodontal epithelial cells

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Atsuo AMANO

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  歯学;細菌;感染症;細胞・組織;シグナル伝達;Porphyromonas gingivalis;細胞内侵入細菌;歯周病;リピッドラフト;エンドサイトーシス;マイクロアレイ;dynamin, Dentistry;Bacteria;Infection;Cell・tissue;Signal transduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390559/
• Molecular analysis of the developmental mechanism of periodontal and oral diseases by the genome analysis of oral biofilm.

  Grant-in-Aid for Scientific Research (B)

  Nihon University

  Shigeyuki HAMADA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  P.gingivalis;線毛;vesicle;S.mutans;糖鎖;ゲノム;Multilocus sequencing, Porpyromonas gingival is;fimbriae;vesicle;Streptococcus mutans;glucose side chain;genome;Multilocus sequencing typing

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390485/
• Analysis in pathogenesis of bacterial lethal soft-tissue infection and application to prevention and therapy.

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  Tohru SHIMIZU

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  細菌感染症;ゲノム解析;トランスクリプトーム;遺伝子発現制御;病原性;ウェルシュ菌;A群レンサ球菌;マイクロアレイ;遺伝子発現調節;オートファジー;遺伝子発現解析;二成分制御系;オートインデューサー;細胞壁;細胞内寄生性細菌;DNAマイクロアレイ;エンドサイトーシス;ストレプトリジンO

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17019021/
• Induction of inflammatory immune response by streptococcal water-insoluble α-glucans and association with periodontal diseases

  Grant-in-Aid for Scientific Research (C)

  Fukuoka Dental College

  Shigefumi OKAMOTO

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  不溶性グルカン;マクロファージ;好中球;炎症性サイトカイン;遊走能;活性酸素;レンサ球菌;免疫応答, Steptococcus sobrinus;water-insoluble α-glucans;inflammatory immune responses;periodontal diseases

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16591824/
• Molecular analysis of cell surface structures of Streptococcus mutans for virulence of infective endocarditis

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Takashi OOSHIMA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  感染性心内膜炎;Streptococcus mutans;心臓弁;疣贅;デンタルプラーク;PCR法;血清型;グルコシルトランスフェラー;血清型特異多糖抗原;Protein antigen c;多型核白血球;貪食作用;食作用, infective endocarditis;Streptococcus mutants;heart valve;vegetation;dental plaque;PCR;serotype

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390605/
• Molecular mimic of group A streptococcal surface proteins

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Shigetada KAWABATA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  A群レンサ球菌;咽頭炎;フィブロネクチン;交叉反応;感染防御抗原;コラーゲン;ケラチン;S.pyogenes;分子擬態;免疫;タンパク質;食細胞, Streptococcus pyogenes;vaccine;fibronectin;invasion;antibody;collagen

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390525/
• 細胞内侵入性細菌に対する細胞内認識システムとオートファジー誘導の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  天野 敦雄

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  オートファジー;A群レンサ球菌;細胞内侵入細菌;自然免疫システム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16044229/
• 歯周病原性細菌の宿主細胞内侵入と歯周組織破壊機構の分子生物学的解析

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  中川 一路

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  歯周病原性細菌;Porphyromonas gingivalis;付着;定着;インテグリン;CHO細胞;フィブロネクチン;ビトロネクチン;歯周病;P.gingivalis;RANKL;AP-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15791040/
• Inhibition of tissue-reparing signaling by P.gingivalis infection

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Nobuo OKAHASHI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  歯周病;再生医学;P.gingivalis;細胞接着;上皮細胞;歯根膜細胞;骨芽細胞, periodontitis;tissue regeneration;P.gingivalis;cellular attachment;epithelial cells;periodontal ligament cells

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390645/
• Characterization of surface proteins on cell invasion of streptococcus pyogenes

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Shigetada KAWABATA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  S.pyogenes;侵入;表層タンパク;フィブロネクチン;結合;Streptococcus pyogenes;細胞侵入;細胞付着;遺伝子;ワクチン;ゲノム;劇症型レンサ球菌感染症;Streptococuus pyogenes;付着, S.pyogenes;invasion;surface protein;fibronectin;pinding

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370582/
• Molecular analysis of streptococcal infections diseases by the functional genomics.

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Shigeyuki HAMADA

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  A群レンサ球菌;劇症化;ゲノム解析;フィブロネクチン結合タンパク;インフルエンザ;遺伝子発現;ヒアルロン酸;オートファジー;付着;侵入;エンドサイトーシス;分解;Streptococcus pyogenes;全ゲノム配列;リアレンジメント;ファージ;ゲノム再構成;ゲノム進化;比較ゲノム解析, group A Streptcoccus;severe invasive diseases;genome analysis;fibronectin binding protein;influenza;gene expression;hyaluronic acid;autophagy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14207074/
• Development of clinical diagnostic test and DNA vaccination based on genotypes of the periodontal pathogen

  Grant-in-Aid for Scientific Research (B)

  OSAKA UNIVERSITY

  Atsuo AMANO

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  歯周病;Porphyromonas gingivalis;遺伝子型;遺伝子タイピング;DNAワクチン;Polymerase chain reaction;線毛;fimA;遺伝子多型;線毛遺伝子fimA;遺伝子診断;遺伝子診断法;ヒト上皮細胞, Porphyromonas gingivalis;Genotype;Genotyping;DNA vaccine;Polymerase chain reaction;fimbriae;fimA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13557181/
• レンサ球菌に対するオプソニン効果を有する免疫グロブリン融合タンパクの開発

  Grant-in-Aid for Exploratory Research

  Osaka University

  浜田 茂幸

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  ファイブロネクチン;Fc融合タンパク;細菌感染;オプソニン;A群レンサ球菌;フィブロネクチン;CD44;COS細胞;CD44-Fc;Fib-Fc

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12877290/
• 大腸菌ベロ毒素Bサブユニットによる細胞機能の阻害メカニズムの解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  中川 一路

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  アポトーシス;上皮細胞;細菌感染;カスパーゼ;Stx;Bサブユニット;テトラサイクリン誘導プロモーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12770135/
• Induction of mucosal immune responses by DNA vaccine encoding Porphyromonas gingivalis fimbriae

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Shigetada KAWABATA

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  歯周病;Porphyromanas gingivalis;線毛;DNAワクチン;粘膜免疫;IgA;Porphyromonas gingivalis;DNA ワクチン;顎下腺, Periodontal Diseases;Porphyromonas gingivalis;fimbriae;DNA Vaccine;Mucosal Immunity;IgA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671769/
• Molecular analyses on Streptococcus pyogenes adherence to and invasion of pharyngeal epithelial cells

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Shigeyuki HAMADA

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  A群レンサ球菌;侵入;フィブロネクチン;ワクチン;細胞外マトリックス;ラミニン;細胞付着;フィプロネクチン;細胞マトリックス;体液性免疫;莢膜;ヒアルロン酸;上皮細胞;hasA, Streptococcus pyogenes;Invasion;Fibronectin;Vaccine;Extracellular matrix;Laminin;Adhesion

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11307039/
• RAP-PCR法を用いた腸管出血性大腸菌感染に対する腸管上皮細胞の発現遺伝子の解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  中川 一路

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  志賀毒素Bサブユニット;アポトーシス;カスパーゼ;テトラサイクリン誘導発現系;炎症性サイトカイン;腸管出血性大腸菌;HEp-2;RAP-PCR;DEC1;CD68

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10770116/
• Swine PathoScan法を用いたタイ・ベトナムでの豚感染症の網羅的解析

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 42:Veterinary medical science, animal science, and related fields

  Kyoto University

  中川 一路

  From 07 Oct. 2022, To 31 Mar. 2026, Granted

  ブタレンサ球菌;Swine PathoScan法;ファージディスプレイ;感染症;ファージ;タイ;ベトナム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KK0096/
• 侵襲性感染症を裏打ちする細菌の環境適応進化とその分子基盤

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  中川 一路

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  レンサ球菌感染症;ヘテロジェナイティ;侵襲性感染症;オートファジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18214/
• アトピー性皮膚炎における角質細胞間脂質と皮膚常在細菌叢のクロストークの解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53050:Dermatology-related

  Kyoto University

  中島 沙恵子

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  皮膚マイクロバイオーム;角質細胞間脂質;アトピー性皮膚炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07764/
• Elucidation of Xenophagy Regulation by Bacterial Glycan Recognition

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49050:Bacteriology-related

  Kyoto University

  中川 一路

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  細菌感染;ゼノファジー;ユビキチン;Ａ群レンサ球菌;自然免疫;糖鎖認識;A群レンサ球菌;認識;GBP1;ガレクチン３;TBK1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24130/

External funds: others

• 人工EVsによる細菌感染制御法開発事業 （2024年度分）

  日本中央競馬会, 日本中央競馬会畜産振興交付金

  From 24 May 2024, To 31 Mar. 2025
• 人工ファージによるSwine PathoScan法の開発事業 (2023年度分)

  日本中央競馬会, 日本中央競馬会畜産振興交付金

  From 01 Apr. 2023, To 31 Mar. 2024
• 細菌糖鎖認識のニューパラダイム:非定型ユビキチン化によるゼノファジー制御の解明

  一般財団法人化学及血清療法研究所, 化血研研究助成

  From 01 Jan. 2022, To 31 Dec. 2024

  中川　一路
• 人工ファージによるSwine PathoScan法の開発事業 (2022年度分)

  日本中央競馬会, 日本中央競馬会畜産振興交付金

  From 01 Apr. 2022, To 31 Mar. 2023

  代表
• 人工ファージによるSwine PathoScan法の開発事業 （2021年度分）

  日本中央競馬会畜産振興交付金

  From 27 May 2021, To 31 Mar. 2022

  中川　一路
• 豚レンサ球菌感染の新規迅速診断法の開発事業 （2020年度分）

  日本中央競馬会畜産振興交付金

  From 01 Apr. 2020, To 31 Mar. 2021

  中川　一路
• 豚レンサ球菌感染の新規迅速診断法の開発事業 （2019年度分）

  日本中央競馬会畜産振興交付金

  From 26 Apr. 2019, To 31 Mar. 2020

  中川　一路

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Microbiology

  B012, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Microbiology I

  E010, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Microbiology

  B011, Fall, Faculty of Medicine, 3.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Microbiology II

  E011, Fall, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Microbiology

  B012, Fall, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Microbiology I

  E010, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Microbiology

  B011, Fall, Faculty of Medicine, 3.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Microbiology II

  E011, Fall, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Microbiology

  B012, Fall, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Microbiology II

  E011, Fall, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Parasitology

  L140, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Microbiology I

  E010, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Microbiology

  L130, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Microbiology

  B011, Fall, Faculty of Medicine, 3.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Microbiology

  L120, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From Apr. 2014, To Mar. 2015

  Microbiology II

  Spring, 医学研究科
• From Apr. 2014, To Mar. 2015

  Microbiology I

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Microbiology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Medical Parasitology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory visit

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Microbiology II

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Microbiology I

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  Microbiology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Medical Parasitology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Microbiology II

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  Microbiology I

  Spring, 医学研究科
• From Apr. 2017, To Mar. 2018

  Microbiology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Medical Parasitology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Microbiology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Microbiology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Microbiology II

  Fall, 医学研究科
• From Apr. 2017, To Mar. 2018

  Microbiology I

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Microbiology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Medical Parasitology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Microbiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Microbiology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Microbiology II

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Microbiology I

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Microbiology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Medical Parasitology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Microbiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Microbiology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Microbiology II

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  Microbiology I

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Microbiology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Medical Parasitology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Microbiology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Microbiology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Microbiology II

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Microbiology I

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Microbiology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Microbiology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Medical Parasitology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Microbiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Microbiology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Microbiology II

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Microbiology I

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）

Participation in PhD Defense

• Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

  YI RENXING, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

  FURUYA　FUTOSHI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor

  SATO ATSUKO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Cervical MUC5B and MUC5AC are Barriers to Ascending Pathogens During Pregnancy　

  UEDA YUSUKE, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐kB activation by recognizing linear ubiquitin chains

  SHINKAWA YUTAKA, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis

  KUNO SOTA, Graduate School of Medicine, Sub-chief Examiner

  25 Jul. 2022
• Longitudinal association between mental health and future antibiotic prescriptions in healthy adults: Results from the LOHAS

  TOCHITANI KENTARO, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity

  TAGUCHI MIREI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

  OKUMURA SHINTARO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• CAGE-seq reveals that HIV-1 latent infection does not trigger unique cellular responses in a Jurkat T cell model

  MATSUI HIROYUKI, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Clinical pictures,treatments,and resource use of norovirus gastroenteritis in long-term care facilities: a survey with a chart review in Japan

  FUJIKI SAORI, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021

Administration

School management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2021

  組換えＤＮＡ実験安全委員会 1号委員
• From 01 Apr. 2018

  組換えＤＮＡ実験安全主任者
• From 01 Apr. 2018, To 31 Mar. 2020

  入学試験企画・研究専門委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  組換えＤＮＡ実験安全委員会 委員
• From 01 Oct. 2019

  研究倫理・安全推進委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  組換えＤＮＡ実験安全委員会 委員（～2019/9/30）、委員長（2019/10/1～）
• From 01 Apr. 2021, To 31 Mar. 2023

  組換えＤＮＡ実験安全委員会 委員長

Faculty management (title, position)

• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科産学共同講座等検討委員会委員
• From 01 Apr. 2023, To 30 Sep. 2024

  医学広報委員会
• From 01 Apr. 2023, To 31 Mar. 2025

  大学評価部局委員会委員
• From 01 Apr. 2023, To 31 Mar. 2025

  医学図書館運営委員会委員
• From 01 Nov. 2014, To 31 Oct. 2018

  期限付特定教員採用審査委員会
• From 01 Apr. 2017, To 31 Mar. 2019

  医学図書館運営委員会
• To 30 Sep. 2019

  医学研究科運営委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  学務委員会
• From 01 Apr. 2017, To 31 Mar. 2021

  入学者選抜方法検討委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  大倉辰三郎・喜美奨学金 選考小委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  総合博物館協議員会
• From 01 Oct. 2020, To 30 Sep. 2022

  産学共同講座等検討委員会委員
• From 01 Oct. 2020, To 31 Mar. 2022

  病原体等安全管理委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  入学者選抜方法検討委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  大倉辰三郎・喜美奨学金選考小委員会委員

Academic, Social Contribution

Committee Memberships

• From 2015, To 2020

  理事, 日本細菌学会
• From 2002

  評議員, 日本細菌学会