Researchers Information System

日本語に切り替えるswitch to english

Nakagawa, Ichiro

Graduate School of Medicine, Medicine Professor

Nakagawa, Ichiro
list
    Last Updated :2022/05/14

    Basic Information

    Faculty

    • 医学部

    Professional Memberships

    • 分子生物学会
    • 国際歯科医学会
    • 基礎歯科医学会
    • 日本細菌学会

    Academic Degree

    • Doctor of Dental Sciences (DDS)(Osaka University)

    Academic Resume (Graduate Schools)

    • Osaka University, Graduate School of Dental Sciences, 修了

    Academic Resume (Undergraduate School/Majors)

    • Osaka University, Faculty of Dentistry, 卒業

    Research History

    • From 2013, To Present
      Kyoto University, Graduate School of Medicine, Department of Microbiology, Professor
    • From 2009, To 2013
      Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Oral Health Sciences Oral Restitution, Professor
    • From 2006, To 2009
      The University of Tokyo, The Institute of Medical Science, 准教授
    • From 2000, To 2006
      Osaka University, School of Dentistry, 講師
    • From 1997, To 2000
      Osaka University, School of Dentistry, 助手

    Profile

    • Profile

      1992年大阪大学歯学部卒業

      1996年大阪大学大学院歯学研究科修了、歯学博士

      1997年大阪大学歯学部・助手

      2000年大阪大学歯学部・講師

      2006年東京大学医科学研究所感染症国際研究センター・助教授

      2007年東京大学医科学研究所感染症国際研究センター・准教授

      2009年東京医科歯科大学大学院医歯学総合研究科・教授

      2014年京都大学大学院医学研究科・教授

    Language of Instruction

    • English
    • Japanese

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      Research

      Research Topics, Overview of the research

      • Research Topics

        Elucidation of survival strategy of bacteria based on whole genome analysis and microbiome analysis
        Analysis of foreign gene acquisition function and evolutionary mechanism of pathogenic bacteria by comparative genome analysis
        Analysis of recognition and elimination mechanism of intracellular invasive bacteria
        Development of novel infectious disease therapeutics based on genomic information
      • Overview of the research

        Up to today, the emphasis of prevention and treatment for bacterial infectious disease has been on the development of antibiotics and vaccines. However, it is difficult to eliminate a specific pathogen by antibiotics because of their properties, and the excessive administration of antibiotics causes the spread of drug-resistant bacteria and dysbiosis. Therefore, it is especially expected to develop novel drugs with a specific effect against each bacterial pathogen.
        The purpose of this study is to establish an effective and large-scale screening system for isolating the functional molecules which can effectively inhibit the interaction between bacterial molecules and host molecules, especially for protein-protein interaction. For this purpose, we develop two screening systems, one is the low molecular weight compounds and the other is nanobodies (VHH), and try to isolate validate candidate substances as seeds for molecular targeted drugs that can prevent and control specific bacterial infection.
        We have already found a low molecular weight compound that showed a strong growth inhibition against Group A Streptococcus (GAS). This compound could inhibit the binding between of Shr, a hemoprotein receptor (iron transporter) of GAS, and the hemoglobin. This compound showed a strong specificity against GAS, and no inhibitory activity against gram-negative bacteria and other gram-positive bacteria. These observations suggest the possibility to develop new drugs targeting specific bacterial species.
        In this application, we focus on two bacterial species, Staphylococcus aureus (becoming increasingly resistant to antibiotics) and GAS (causing serious invasive infections such as necrotizing fasciitis and streptococcal toxic shock syndrome) to find novel growth inhibitory molecules. We precisely characterize the conformation and physical-chemical properties between target bacterial molecules and host molecules based on the crystal structure, and also establish a screening system that can effectively and high-sensitively analyze the binding state between them. The candidate substances are used as lead compounds for chemical modifications or genetic modifications, and the most effective substance is selected for further analysis. We also construct gene knockout mutants or amino acid substitution mutants of putative binding sites for the candidate substances in target bacteria, and evaluate the effect of these candidates for comparing the growth of these parents strains and mutants and the risk for acquisition of drug resistance. Finally, we evaluate toxicity and protective ability of candidate compounds by animal experiments using mice.
        We believe that this study might become a milestone providing a new treatment strategy for multidrug-resistant bacterial infection and intractable infectious diseases.

      Research Interests

      • Antibody
      • Pharmacology
      • 病原性
      • Bacteriology
      • ゲノム
      • 細胞生物学
      • 感染症
      • genome
      • cell biology
      • infectious diseases

      Research Areas

      • Life sciences, Bacteriology, Bactreriology
      • Life sciences, Oral medicine

      Papers

      • Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor.
        Tsukushi Yamawaki; Makoto Nakakido; Kan Ujiie; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto
        Biochemical and biophysical research communications, 06 Aug. 2021, Peer-reviewed
      • Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.
        Chihiro Aikawa; Kiyosumi Kawashima; Chihiro Fukuzaki; Makoto Nakakido; Kazunori Murase; Takashi Nozawa; Kouhei Tsumoto; Ichiro Nakagawa
        Biochemical and biophysical research communications, 12 Jun. 2021, Peer-reviewed
      • Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering.
        Masahiro Shimogishi; Takayasu Watanabe; Masaki Shibasaki; Takahiko Shiba; Keiji Komatsu; Takashi Nemoto; Kazuyuki Ishihara; Yoshio Nakano; Takanori Iwata; Shohei Kasugai; Ichiro Nakagawa
        Journal of periodontal research, 31 May 2021, Peer-reviewed
      • Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase.
        Takashi Nozawa; Junpei Iibushi; Hirotaka Toh; Atsuko Minowa-Nozawa; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa
        mBio, 09 Feb. 2021, Peer-reviewed
      • Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs.
        Atsuko Minowa-Nozawa; Takashi Nozawa; Daisuke Takamatsu; Akemi Yoshida; Kazunori Murase; Taisei Kikuchi; Kasumi Ishida-Kuroki; Yoshihiro Nitta; Tsutomu Sekizaki; Ichiro Nakagawa
        Microbiology resource announcements, 19 Nov. 2020, Peer-reviewed
      • Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 2009.
        Kazunori Murase; Takashi Nozawa; Chihiro Aikawa; Miki Nagao; Tadayoshi Ikebe; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa
        Microbiology resource announcements, 15 Oct. 2020, Peer-reviewed
      • Complete Genome Sequence of Helicobacter pylori Strain ATCC 43504, a Type Strain That Can Infect Gerbils.
        Ryo Kinoshita-Daitoku; Yoshitoshi Ogura; Kotaro Kiga; Fumito Maruyama; Tomoyo Kondo; Ichiro Nakagawa; Tetsuya Hayashi; Hitomi Mimuro
        Microbiology resource announcements, 30 Apr. 2020, Peer-reviewed
      • Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.
        Mototsugu Tanaka; Ryo Kinoshita-Daitoku; Kotaro Kiga; Takahito Sanada; Bo Zhu; Tokuju Okano; Chihiro Aikawa; Tamako Iida; Yoshitoshi Ogura; Tetsuya Hayashi; Koshu Okubo; Miho Kurosawa; Junichi Hirahashi; Toshihiko Suzuki; Ichiro Nakagawa; Masaomi Nangaku; Hitomi Mimuro
        Scientific reports, 24 Feb. 2020, Peer-reviewed
      • Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.
        Ichiro Takahashi; Koji Hosomi; Takahiro Nagatake; Hirokazu Toubou; Daiki Yamamoto; Ikue Hayashi; Yosuke Kurashima; Shintaro Sato; Naoko Shibata; Yoshiyuki Goto; Fumito Maruyama; Ichiro Nakagawa; Asaomi Kuwae; Akio Abe; Jun Kunisawa; Hiroshi Kiyono
        International immunology, 07 Feb. 2020, Peer-reviewed
      • TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
        Takashi Nozawa; Shunsuke Sano; Atsuko Minowa-Nozawa; Hirotaka Toh; Shintaro Nakajima; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa
        Nature communications, 07 Feb. 2020, Peer-reviewed
      • Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy.
        Hirotaka Toh; Takashi Nozawa; Atsuko Minowa-Nozawa; Miyako Hikichi; Shintaro Nakajima; Chihiro Aikawa; Ichiro Nakagawa
        Autophagy, Feb. 2020, Peer-reviewed
      • Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles.
        Takashi Nozawa; Ichiro Nakagawa
        Methods in molecular biology (Clifton, N.J.), 2020
      • Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection.
        Ching-Yu Lin; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Miyako Hikichi; Junpei Iibushi; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2020, Peer-reviewed
      • Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity
        Kaori Fujiwara-Takahashi; Takayasu Watanabe; Masahiro Shimogishi; Masaki Shibasaki; Makoto Umeda; Yuichi Izumi; Ichiro Nakagawa
        Journal of Oral Microbiology, 01 Jan. 2020, Peer-reviewed
      • Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan.
        Miyako Hikichi; Miki Nagao; Kazunori Murase; Chihiro Aikawa; Takashi Nozawa; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa
        Microbiology resource announcements, 21 Nov. 2019, Peer-reviewed
      • 16S rRNA Gene Amplicon Sequence Data from Chicken Cecal Feces from Vietnam and Thailand.
        N Takeshita; H Kim; K Witoonsatian; M Tohya; TH Võ; N Boonyong; TPB Nguyễn; I Nakagawa; N Meekhanon; NH Nguyễn; T Sekizaki
        Microbiology resource announcements, Aug. 2019, Peer-reviewed
      • LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy.
        CY Lin; T Nozawa; A Minowa-Nozawa; H Toh; C Aikawa; I Nakagawa
        Cellular microbiology, Apr. 2019, Peer-reviewed
      • Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients.
        K Funahashi; T Shiba; T Watanabe; K Muramoto; Y Takeuchi; T Ogawa; Y Izumi; T Sekizaki; I Nakagawa; K Moriyama
        Progress in orthodontics, Mar. 2019, Peer-reviewed
      • Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203).
        K Nagaoka; S Konno; K Murase; T Kikuchi; Y Morinaga; K Yanagihara; I Nakagawa
        Microbiology resource announcements, Feb. 2019, Peer-reviewed
      • Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.
        Hirotaka Toh; Ching-Yu Lin; Shintaro Nakajima; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2019, Peer-reviewed
      • Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus.
        Shunsuke Yamada; Masaki Shibasaki; Kazunori Murase; Takayasu Watanabe; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa
        BMC microbiology, Jan. 2019, Peer-reviewed
      • Characterization of pig saliva as the major natural habitat of Streptococcus suis by analyzing oral, fecal, vaginal, and environmental microbiota.
        K Murase; T Watanabe; S Arai; H Kim; M Tohya; K Ishida-Kuroki; TH Võ; TPB Nguyễn; I Nakagawa; R Osawa; NH Nguyễn; T Sekizaki
        PloS one, 2019, Peer-reviewed
      • Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 335 Strain HU-GS5823, Isolated from a Human Patient in Japan with Severe Invasive Infection.
        K Nagaoka; S Konno; K Murase; T Kikuchi; I Nakagawa
        Microbiology resource announcements, Nov. 2018, Peer-reviewed
      • RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus.
        Koji Nakajima; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Shunsuke Yamada; Chiro Aikawa; Ichiro Nakagawa
        Autophagy, Oct. 2018, Peer-reviewed
      • Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay
        S Arai; H Kim; T Watanabe; M Tohya; E Suzuki; K Ishida-Kuroki; F Maruyama; K Murase; I Nakagawa; T Sekizaki
        American Journal of Veterinary Research, Sep. 2018, Peer-reviewed
      • Distribution of single nucleotide polymorphisms in protein-coding regions of emm12 Group A Streptococcus from two scarlet fever outbreaks
        M Shibasaki; T Watanabe; S Kasugai; I Nakagawa
        J Stomatol Soc Jpn, Mar. 2018, Peer-reviewed
      • Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing
        K Okada; W Wongboot; S Chantaroj; W Natakuathung; A Roobthaisong; W Kamjumphol; F Maruyama; T Takemura; I Nakagawa; M Ohnishi; S Hamada
        Scientific Reports, Jan. 2018, Peer-reviewed
      • Pig saliva as a Streptococcus suis reservoir and potential source of infection on farms: Implications from a novel quantitative PCR.
        S Arai; H Kim; T Watanabe; M Tohya; E Suzuki; K Ishida-Kuroki; F Maruyama; K Murase; I Nakagawa; T Sekizaki
        American Journal of Veterinary Research, 2018, Peer-reviewed
      • NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex.
        Chihiro Aikawa; Shintaro Nakajima; Miho Karimine; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Shunsuke Yamada; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2018, Peer-reviewed
      • Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis.
        Y Ohara; Y Ozeki; Y Tateishi; T Mashima; F Arisaka; Y Tsunaka; Y Fujiwara; A Nishiyama; Y Yoshida; K Kitadokoro; H Kobayashi; Y Kaneko; I Nakagawa; R Maekura; S Yamamoto; M Katahira; S Matsumoto
        PloS ONE, 2018, Peer-reviewed
      • Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
        Kouyuki Hirayasu; Fumiji Saito; Tadahiro Suenaga; Kyoko Shida; Noriko Arase; Keita Oikawa; Toshifumi Yamaoka; Hiroyuki Murota; Hiroji Chibana; Ichiro Nakagawa; Tomoko Kubor; Hiroki Nagai; Yuji Nakamaru; Ichiro Katayama; Marco Colonna; Hisashi Arase
        CYTOKINE, Dec. 2017
      • Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes
        Masato Hoshino; Makoto Nakakido; Satoru Nagatoishi; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2017, Peer-reviewed
      • Erruatum to: Rab35 GTPase recruits NDP52 to autophagy targets. (EMBO Journal, 2017, 36, 18, 2790-2807)
        Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa
        EMBO Journal, Nov. 2017, Peer-reviewed
      • Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam
        Taichiro Takemura; Kazunori Murase; Fumito Maruyama; Thi Luong Tran; Atsushi Ota; Ichiro Nakagawa; Dong Tu Nguyen; Tu Cuong Ngo; Thi Hang Nguyen; Asako Tokizawa; Masatomo Morita; Makoto Ohnishi; Binh Minh Nguyen; Tetsu Yamashiro
        INFECTION GENETICS AND EVOLUTION, Oct. 2017, Peer-reviewed
      • Rab35 GTPase recruits NPD52 to autophagy targets
        Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa
        EMBO JOURNAL, Sep. 2017, Peer-reviewed
      • Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis
        Hirokazu Yano; Tomotada Lwamoto; Yukiko Nishiuchi; Chie Nakajima; Daria A. Starkova; Igor Mokrousov; Olga Narvskaya; Shiomi Yoshida; Kentaro Arikawa; Noriko Nakanishi; Ken Osaki; Ichiro Nakagawa; Manabu Ato; Yasuhiko Suzuki; Fumito Maruyama
        GENOME BIOLOGY AND EVOLUTION, Sep. 2017, Peer-reviewed
      • Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species
        Takayasu Watanabe; Masaki Shibasaki; Fumito Maruyama; Tsutomu Sekizaki; Ichiro Nakagawa
        PLOS ONE, Aug. 2017, Peer-reviewed
      • A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis
        Masatoshi Okura; Takashi Nozawa; Takayasu Watanabe; Kazunori Murase; Ichiro Nakagawa; Daisuke Takamatsu; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Shigeyuki Hamada; Fumito Maruyama
        GENOME BIOLOGY AND EVOLUTION, Apr. 2017, Peer-reviewed
      • Active microbiota show specific correlationships in peri-implantitis and periodontitis
        H Kachi; N Maruyama; F Maruyama; T Shiba; T Watanabe; A Goda; K Murase; Y Michi; Y Takeuchi; Y Izumi; K Harada; I Nakagawa
        J Stomatol Soc Jpn, Mar. 2017, Peer-reviewed
      • Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG
        Shintaro Nakajima; Chihiro Aikawe; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Ichiro Nakagawa
        PLOS ONE, Jan. 2017, Peer-reviewed
      • The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes
        Takashi Nozawa; Atsuko Minowa-Nozawa; Chihiro Aikawa; Ichiro Nakagawa
        AUTOPHAGY, 2017, Peer-reviewed
      • The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation
        Takashi Nozawa; Chihiro Aikawa; Atsuko Minowa-Nozawa; Ichiro Nakagawa
        AUTOPHAGY, 2017, Peer-reviewed
      • YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses
        Amonrattana Roobthaisong; Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Ichiro Nakagawa
        PLOS ONE, Jan. 2017, Peer-reviewed
      • DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan
        Tejaswini Kulkarni; Chihiro Aikawa; Takashi Nozawa; Kazunori Murase; Fumito Maruyama; Ichiro Nakagawa
        BMC MICROBIOLOGY, Oct. 2016, Peer-reviewed
      • Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms
        Takahiko Shiba; Takayasu Watanabe; Hirokazu Kachi; Tatsuro Koyanagi; Noriko Maruyama; Kazunori Murase; Yasuo Takeuchi; Fumito Maruyama; Yuichi Izumi; Ichiro Nakagawa
        SCIENTIFIC REPORTS, Aug. 2016, Peer-reviewed
      • Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones
        Mari Tohya; Takayasu Watanabe; Fumito Maruyama; Sakura Arai; Atsushi Ota; Taryn B. T. Athey; Nahuel Fittipaldi; Ichiro Nakagawa; Tsutomu Sekizaki
        PLOS ONE, Jul. 2016, Peer-reviewed
      • Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1.
        T Furusawa; H Iwano; H Higuchi; M Usui; F Maruyama; I Nakagawa; H Yokota; Y Tamura
        Genome Announcements, May 2016, Peer-reviewed
      • Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2.
        Kouyuki Hirayasu; Fumiji Saito; Tadahiro Suenaga; Kyoko Shida; Noriko Arase; Keita Oikawa; Toshifumi Yamaoka; Hiroyuki Murota; Hiroji Chibana; Ichiro Nakagawa; Tomoko Kubori; Hiroki Nagai; Yuji Nakamaru; Ichiro Katayama; Marco Colonna; Hisashi Arase
        Nature microbiology, 25 Apr. 2016, Peer-reviewed
      • Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand
        W Paveenkittiporn; T Nozawa; S Dejsirilert; I Nakagawa; S Hamada
        EPIDEMIOLOGY AND INFECTION, Mar. 2016, Peer-reviewed
      • Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes
        Seiichiro Oda; Takashi Nozawa; Atsuko Nozawa-Minowa; Misako Tanaka; Chihiro Aikawa; Hiroyuki Harada; Ichiro Nakagawa
        PLOS ONE, Jan. 2016, Peer-reviewed
      • Streptococcus pyogenes Genomics
        F Maruyama; T Watanabe; I Nakagawa
        Streptococcus pyogenes : Basic Biology to Clinical Manifestations, 2016, Peer-reviewed
      • Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172
        Takayuki Wada; Fumito Maruyama; Tomotada Iwamoto; Shinji Maeda; Taro Yamamoto; Ichiro Nakagawa; Saburo Yamamoto; Naoya Ohara
        SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed
      • Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes
        Shigeyuki Hamada; Shigetada Kawabata; Ichiro Nakagawa
        PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, Dec. 2015, Peer-reviewed
      • Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae
        Kazuhisa Okada; Wirongrong Natakuathung; Mathukorn Na-Ubol; Amonrattana Roobthaisong; Warawan Wongboot; Fumito Maruyama; Ichiro Nakagawa; Siriporn Chantaroj; Shigeyuki Hamada
        EMERGING INFECTIOUS DISEASES, Jul. 2015, Peer-reviewed
      • Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates
        Kana Minegishi; Takayasu Watanabe; Asuka Furukawa; Keisuke Uchida; Yoshimi Suzuki; Takumi Akashi; Fumito Maruyama; Ichiro Nakagawa; Yoshinobu Eishi
        SCIENTIFIC REPORTS, May 2015, Peer-reviewed
      • Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease
        Akiko Endo; Takayasu Watanabe; Nachiko Ogata; Takashi Nozawa; Chihiro Aikawa; Shinichi Arakawa; Fumito Maruyama; Yuichi Izumi; Ichiro Nakagawa
        ISME JOURNAL, Mar. 2015, Peer-reviewed
      • Rab Proteins in Autophagy: Streptococcus Model
        T Nozawa; I Nakagawa
        Autophagy, Infection, and the Immune Response, Feb. 2015, Peer-reviewed
      • Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion
        Bijaya Haobam; Takashi Nozawa; Atsuko Minowa-Nozawa; Misako Tanaka; Seiichiro Oda; Takayasu Watanabe; Chihiro Aikawa; Fumito Maruyama; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Dec. 2014, Peer-reviewed
      • Evaluation of biofilm formation in the presence of saliva on poly(ethylene-glycol)-deposited titanium
        Ayako Kawabe; Ichiro Nakagawa; Zuisei Kanno; Yusuke Tsutsumi; Takao Hanawa; Takashi Ono
        DENTAL MATERIALS JOURNAL, Oct. 2014, Peer-reviewed
      • Intraindividual variation in core microbiota in peri-implantitis and periodontitis
        Noriko Maruyama; Fumito Maruyama; Yasuo Takeuchi; Chihiro Aikawa; Yuichi Izumi; Ichiro Nakagawa
        SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed
      • The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation
        Makoto Nakakido; Chihiro Aikawa; Ichiro Nakagawa; Kouhei Tsumoto
        JOURNAL OF BIOCHEMISTRY, Sep. 2014, Peer-reviewed
      • Comparative Genomic Characterization of a Thailand-Myanmar Isolate, MS6, of Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a "US Gulf Coast" Clone
        Kazuhisa Okada; Mathukorn Na-Ubol; Wirongrong Natakuathung; Amonrattana Roobthaisong; Fumito Maruyama; Ichiro Nakagawa; Siriporn Chantaroj; Shigeyuki Hamada
        PLOS ONE, Jun. 2014, Peer-reviewed
      • Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis
        Masatoshi Okura; ClauDe lachance; Makoto Osaki; Tsutomu Sekizaki; Fumito Maruyama; Takashi Nozawa; Ichiro Nakagawa; Shigeyuki Hamada; Celine Rossignol; Marcelo Gottschalk; Daisuke Takamatsu
        JOURNAL OF CLINICAL MICROBIOLOGY, May 2014, Peer-reviewed
      • Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw
        A Goda; F Maruyama; Y Michi; I Nakagawa; K Harada
        CLINICAL MICROBIOLOGY AND INFECTION, May 2014, Peer-reviewed
      • Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011.
        Naomi Ohnishi; Fumito Maruyama; Hirohito Ogawa; Hirokazu Kachi; Shunsuke Yamada; Daisuke Fujikura; Ichiro Nakagawa; Mudenda B. Hang'ombe; Yuka Thomas; Aaron S. Mweene; Hideaki Higashi
        Genome Announcements, Mar. 2014, Peer-reviewed
      • Streptococcus pyogenes Escapes from Autophagy
        Ichiro Nakagawa
        CELL HOST & MICROBE, Dec. 2013, Peer-reviewed
      • Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria
        Chiaki Ito; Yohei Saito; Takashi Nozawa; Shigemoto Fujii; Tomohiro Sawa; Hirofumi Inoue; Tetsuro Matsunaga; Shahzada Khan; Soichiro Akashi; Ryota Hashimoto; Chihiro Aikawa; Eriko Takahashi; Hiroshi Sagara; Masaaki Komatsu; Keiji Tanaka; Takaaki Akaike; Ichiro Nakagawa; Hirokazu Arimoto
        MOLECULAR CELL, Dec. 2013, Peer-reviewed
      • Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation
        Masatoshi Okura; Daisuke Takamatsu; Fumito Maruyama; Takashi Nozawa; Ichiro Nakagawa; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Yumi Kumagai; Shigeyuki Hamada
        APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Apr. 2013, Peer-reviewed
      • CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination
        Takayasu Watanabe; Takashi Nozawa; Chihiro Aikawa; Atsuo Amano; Fumito Maruyama; Ichiro Nakagawa
        GENOME BIOLOGY AND EVOLUTION, 2013, Peer-reviewed
      • Molecular typing of Streptococcus mutans
        K Nakano; I Nakagawa; S Alaluusua; T Ooshima
        Molecular Typing in Bacterial Infections, Jan. 2013, Peer-reviewed
      • Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient.
        K Minegishi; C Aikawa; A Furukawa; T Watanabe; T Nakano; Y Ogura; Y Ohtsubo; K Kurokawa; T Hayashi; F Maruyama; I Nakagawa; Y Eishi
        Genome Announcements, Jan. 2013, Peer-reviewed
      • Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis
        Manabu Ogawa; Sunao Sugita; Norio Shimizu; Ken Watanabe; Ichiro Nakagawa; Manabu Mochizuki
        JAPANESE JOURNAL OF OPHTHALMOLOGY, Nov. 2012, Peer-reviewed
      • The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection
        Takashi Nozawa; Chihiro Aikawa; Akira Goda; Fumito Maruyama; Shigeyuki Hamada; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Aug. 2012, Peer-reviewed
      • Complete Genome Sequence of the Serotype k Streptococcus mutans Strain LJ23
        Chihiro Aikawa; Nayuta Furukawa; Takayasu Watanabe; Kana Minegishi; Asuka Furukawa; Yoshinobu Eishi; Kenshiro Oshima; Ken Kurokawa; Masahira Hattori; Kazuhiko Nakano; Fumito Maruyama; Ichiro Nakagawa; Takashi Ooshima
        JOURNAL OF BACTERIOLOGY, May 2012, Peer-reviewed
      • Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis
        Akinobu Aoki; Yasuko Shibata; Soichiro Okano; Fumito Maruyama; Atsuo Amano; Ichiro Nakagawa; Yoshimitsu Abiko
        MICROBIAL PATHOGENESIS, Jan. 2012, Peer-reviewed
      • Genotypic and PFGE/MLVA Analyses of Vibrio cholerae O1: Geographical Spread and Temporal Changes during the 2007-2010 Cholera Outbreaks in Thailand
        Kazuhisa Okada; Amonrattana Roobthaisong; Ichiro Nakagawa; Shigeyuki Hamada; Siriporn Chantaroj
        PLOS ONE, Jan. 2012, Peer-reviewed
      • Cellular vacuolation induced by Clostridium perfringens epsilon-toxin
        Masahiro Nagahama; Yukari Itohayashi; Hideki Hara; Masahiro Higashihara; Yusuke Fukatani; Teruhisa Takagishi; Masataka Oda; Keiko Kobayashi; Ichiro Nakagawa; Jun Sakurai
        FEBS JOURNAL, Sep. 2011, Peer-reviewed
      • The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke
        Kazuhiko Nakano; Kazuya Hokamura; Naho Taniguchi; Koichiro Wada; Chiho Kudo; Ryota Nomura; Ayuchi Kojima; Shuhei Naka; Yoshinori Muranaka; Min Thura; Atsushi Nakajima; Katsuhiko Masuda; Ichiro Nakagawa; Pietro Speziale; Nobumitsu Shimada; Atsuo Amano; Yoshinori Kamisaki; Tokutaro Tanaka; Kazuo Umemura; Takashi Ooshima
        NATURE COMMUNICATIONS, Sep. 2011, Peer-reviewed
      • Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification
        K Yamato; N Egawa; S Endo; K Ui-Tei; T Yamada; K Saigo; I Hyodo; T Kiyono; I Nakagawa
        CANCER GENE THERAPY, Aug. 2011, Peer-reviewed
      • Complete Genome Sequence of the Bacterium Porphyromonas gingivalis TDC60, Which Causes Periodontal Disease
        Takayasu Watanabe; Fumito Maruyama; Takashi Nozawa; Akinobu Aoki; Soichiro Okano; Yasuko Shibata; Kenshiro Oshima; Ken Kurokawa; Masahira Hattori; Ichiro Nakagawa; Yoshimitsu Abiko
        JOURNAL OF BACTERIOLOGY, Aug. 2011, Peer-reviewed
      • CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes
        Takashi Nozawa; Nayuta Furukawa; Chihiro Aikawa; Takayasu Watanabe; Bijaya Haobam; Ken Kurokawa; Fumito Maruyama; Ichiro Nakagawa
        PLOS ONE, May 2011, Peer-reviewed
      • Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.
        S Endo; K Yamato; S Hirai; T Moriwaki; K Fukuda; H Suzuki; M Abei; I Nakagawa; I Hyodo
        Cancer Science, Mar. 2011, Peer-reviewed
      • Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice.
        T Izumo; F Izumi; I Nakagawa; Y Kitagawa; H Shibata; Y Kiso
        Bioscience and Microflora, 2011, Peer-reviewed
      • Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.
        A Sakurai; F Maruyama; J Funao; T Nozawa; C Aikawa; N Okahashi; S Shintani; S Hamada; T Ooshima; I Nakagawa
        Journal of Biological Chemistry, Jul. 2010, Peer-reviewed
      • Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells
        Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Kohei Tsumoto; Shigeyuki Hamada; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Jun. 2010, Peer-reviewed
      • The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.
        A Sakurai; F Maruyama; J Funao; T Nozawa; C Aikawa; N Okahashi; S Shintani; S Hamada; T Ooshima; I Nakagawa
        J Biol Chem, May 2010, Peer-reviewed
      • The dawning era of comprehensive transcriptome analysis in cellular microbiology
        Chihiro Aikawa; Fumito Maruyama; Ichiro Nakagawa
        FRONTIERS IN MICROBIOLOGY, 2010, Peer-reviewed
      • An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.
        H Yamaguchi; I Nakagawa; A Yamamoto; A Amano; T Noda; T Yoshimori
        PLoS Pathogens, Nov. 2009, Peer-reviewed
      • Listeria monocytogenes ActA-mediated escape from autophagic recognition
        Yuko Yoshikawa; Michinaga Ogawa; Torsten Hain; Mitsutaka Yoshida; Makoto Fukumatsu; Minsoo Kim; Hitomi Mimuro; Ichiro Nakagawa; Toru Yanagawa; Tetsuro Ishii; Akira Kakizuka; Elizabeth Sztul; Trinad Chakraborty; Chihiro Sasakawa
        NATURE CELL BIOLOGY, Oct. 2009, Peer-reviewed
      • Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content
        Fumito Maruyama; Mitsuhiko Kobata; Ken Kurokawa; Keishin Nishida; Atsuo Sakurai; Kazuhiko Nakano; Ryota Nomura; Shigetada Kawabata; Takashi Ooshima; Kenta Nakai; Masahira Hattori; Shigeyuki Hamada; Ichiro Nakagawa
        BMC GENOMICS, Aug. 2009, Peer-reviewed
      • Bacterial infection and autophagy.
        I Nakagawa
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jun. 2009, Peer-reviewed
      • Bacterial genome analysis and its applications for infectious diseases.
        I Nakagawa
        Nihon rinsho. Japanese journal of clinical medicine, Jun. 2009, Peer-reviewed
      • Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids
        Fumito Maruyama; Takashi Nozawa; Chihiro Aikawa; Atsuo Sakurai; Ichiro Nakagawa
        JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Apr. 2009, Peer-reviewed
      • STREPTOCOCCUS-, SHIGELLA-, AND LISTERIA-INDUCED AUTOPHAGY
        Michinaga Ogawa; Ichiro Nakagawa; Yuko Yoshikawa; Torsten Hain; Trinad Chakraborty; Chihiro Sasakawa
        METHODS IN ENZYMOLOGY: AUTOPHAGY IN MAMMALIAN SYSTEMS, VOL 452, PT B, 2009, Peer-reviewed
      • Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry
        Masako Ishimaru; Masuyoshi Yamada; Ichiro Nakagawa; Sumio Sugano
        JOURNAL OF BREATH RESEARCH, Sep. 2008, Peer-reviewed
      • Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13
        Atsuo Sakurai; Nobuo Okahashi; Fumito Maruyama; Takashi Ooshima; Shigeyuki Hamada; Ichiro Nakagawa
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2008, Peer-reviewed
      • Demonstration of Mother-to-Child Transmission of Streptococcus mutans Using Multilocus Sequence Typing
        J Lapirattanakul; K Nakano; R Nomura; S Hamada; I Nakagawa; T Ooshima
        CARIES RESEARCH, 2008, Peer-reviewed
      • Role of Hrs in maturation of autophagosomes in mammalian cells
        Keiichi Tamai; Nobuyuki Tanaka; Atsuki Nara; Akitsugu Yamamoto; Ichiro Nakagawa; Tamotsu Yoshimori; Yoshiyuki Ueno; Tooru Shimosegawa; Kazuo Sugamura
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed
      • Streptococcus mutans clonal variation revealed by multilocus sequence typing
        Kazuhiko Nakano; Jinthana Lapirattanakul; Ryota Nomura; Hirotoshi Nemoto; Satu Alaluusua; Lisa Groenroos; Martti Vaara; Shigeyuki Hamada; Takashi Oshima; Ichiro Nakagawa
        JOURNAL OF CLINICAL MICROBIOLOGY, Aug. 2007, Peer-reviewed
      • Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype
        Takahiro Kato; Shinji Kawai; Kazuhiko Nakano; Hiroaki Inaba; Masae Kuboniwa; Ichiro Nakagawa; Kayoko Tsuda; Hiroko Omori; Takashi Ooshima; Tamotsu Yoshimori; Atsuo Amano
        CELLULAR MICROBIOLOGY, Mar. 2007, Peer-reviewed
      • Autophagy in innate immunity against intracellular bacteria
        Atsuo Amano; Ichiro Nakagawa; Tamotsu Yoshimori
        JOURNAL OF BIOCHEMISTRY, Aug. 2006, Peer-reviewed
      • Host defense mechanism by autophagy.
        I Nakagawa; T Yoshimori
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2006, Peer-reviewed
      • Genome sequence of an invasive M3 strain of Streptococcus pyogenes.
        I Nakagawa
        Nippon saikingaku zasshi. Japanese journal of bacteriology, Aug. 2006, Peer-reviewed
      • Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae
        I Nakagawa; H Inaba; T Yamamura; T Kato; S Kawai; T Oshima; A Amano
        INFECTION AND IMMUNITY, Jul. 2006, Peer-reviewed
      • Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells
        Akane Takemura; Ichiro Nakagawa; Shinji Kawai; Hiroaki Inaba; Takahiro Kato; Shigeyuki Hamada; Atsuo Amano
        JOURNAL OF PERIODONTOLOGY, May 2006, Peer-reviewed
      • Intracellularly invading Streptococcus pyogenes is degraded by autophagic machinery
        I Nakagawa; S Hamada
        International Congress Series, Apr. 2006, Peer-reviewed
      • Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome C release and cell death, independent of vacuolation
        E Yamasaki; A Wada; A Kumatori; I Nakagawa; J Funao; M Nakayama; J Hisatsune; M Kimura; J Moss; T Hirayama
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed
      • Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae
        H Inaba; S Kawai; T Kato; I Nakagawa; A Amano
        INFECTION AND IMMUNITY, Jan. 2006, Peer-reviewed
      • Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle
        K Tsuda; A Amano; K Umebayashi; H Inaba; I Nakagawa; Y Nakanishi; T Yoshimori
        CELL STRUCTURE AND FUNCTION, Dec. 2005, Peer-reviewed
      • Host defense mechanism by autophagy.
        I Nakagawa
        Nippon saikingaku zasshi. Japanese journal of bacteriology, Aug. 2005, Peer-reviewed
      • Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents
        K Tamura; K Nakano; R Nomura; S Miyake; I Nakagawa; A Amano; T Ooshima
        JOURNAL OF PERIODONTOLOGY, May 2005, Peer-reviewed
      • Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases.
        S Hamada; I Nakagawa; S Kawabata
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2005, Peer-reviewed
      • Inhibitory effects of Porphyromonas gingivalis timbriae on interactions between extracellular matrix proteins and cellular integrins
        I Nakagawa; A Amano; H Inaba; S Kawai; S Hamada
        MICROBES AND INFECTION, Feb. 2005, Peer-reviewed
      • Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans
        K Nakano; R Nomura; I Nakagawa; S Hamada; T Ooshima
        CARIES RESEARCH, 2005, Peer-reviewed
      • Autophagy as an Innate Defense System against Invading Pathogenic Bacteria
        I Nakagawa
        Journal of Oral Biosciences, 2005, Peer-reviewed
      • Autophagy defends cells against invading group a Streptococcus
        I Nakagawa; A Amano; N Mizushima; A Yamamoto; H Yamaguchi; T Kamimoto; J Nara; J Funao; M Nakata; K Tsuda; S Hamada; T Yoshimori
        SCIENCE, Nov. 2004, Peer-reviewed
      • Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains
        K Nakano; R Nomura; N Shimizu; I Nakagawa; S Hamada; T Ooshima
        JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 2004, Peer-reviewed
      • Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells
        I Nakagawa; M Nakata; S Kawabata; S Hamada
        CELLULAR MICROBIOLOGY, Oct. 2004, Peer-reviewed
      • Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model
        K Nakano; M Kuboniwa; I Nakagawa; T Yamamura; R Nomura; N Okahashi; T Ooshima; A Amano
        ORAL MICROBIOLOGY AND IMMUNOLOGY, Jun. 2004, Peer-reviewed
      • Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis
        A Amano; I Nakagawa; N Okahashi; N Hamada
        JOURNAL OF PERIODONTAL RESEARCH, Apr. 2004, Peer-reviewed
      • Porphyromonas gingivalis induces receptor activator of NF-kappa B ligand expression in osteoblasts through the activator protein 1 pathway
        N Okahashi; H Inaba; I Nakagawa; T Yamamura; M Kuboniwa; K Nakayama; S Hamada; A Amano
        INFECTION AND IMMUNITY, Mar. 2004, Peer-reviewed
      • A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice
        S Okamoto; S Kawabata; I Nakagawa; Y Okuno; T Goto; K Sano; S Hamada
        OPTIONS FOR THE CONTROL OF INFLUENZA V, 2004, Peer-reviewed
      • Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity
        K Nakano; R Nomura; I Nakagawa; S Hamada; T Ooshima
        JOURNAL OF CLINICAL MICROBIOLOGY, Jan. 2004, Peer-reviewed
      • Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappa B ligand
        A Sakurai; N Okahashi; I Nakagawa; S Kawabata; A Amano; T Ooshima; S Hamada
        INFECTION AND IMMUNITY, Oct. 2003, Peer-reviewed
      • Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution
        I Nakagawa; K Kurokawa; A Yamashita; M Nakata; Y Tomiyasu; N Okahashi; S Kawabata; K Yamazaki; T Shiba; T Yasunaga; H Hayashi; M Hattori; S Hamada
        GENOME RESEARCH, Jun. 2003, Peer-reviewed
      • Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice
        S Okamoto; S Kawabata; I Nakagawa; Y Okuno; T Goto; K Sano; S Hamada
        JOURNAL OF VIROLOGY, Apr. 2003, Peer-reviewed
      • Infection by Streptococcus pyogenes induces the receptor activator of NF-kappa B ligand expression in mouse osteoblastic cells
        N Okahashi; A Sakurai; I Nakagawa; T Fujiwara; S Kawabata; A Amano; S Hamada
        INFECTION AND IMMUNITY, Feb. 2003, Peer-reviewed
      • Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis
        I Nakagawa; A Amano; Y Ohara-Nemoto; N Endoh; I Morisaki; S Kimura; S Kawabata; S Hamada
        JOURNAL OF PERIODONTAL RESEARCH, Dec. 2002, Peer-reviewed
      • Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients
        Y Terao; S Kawabata; M Nakata; I Nakagawa; S Hamada
        JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed
      • A novel, anchorless streptococcal surface protein that binds to human immunoglobulins
        S Kawabata; Y Tamura; J Murakami; Y Terao; I Nakagawa; S Hamada
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2002, Peer-reviewed
      • Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice
        I Nakagawa; M Nakata; T Yamamura; S Wakisaka; S Kawabata; S Hamada
        MICROBIAL PATHOGENESIS, Aug. 2002, Peer-reviewed
      • Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9
        J Murakami; S Kawabata; Y Terao; K Kikuchi; K Totsuka; A Tamaru; C Katsukawa; K Moriya; I Nakagawa; I Morisaki; S Hamada
        EPIDEMIOLOGY AND INFECTION, Jun. 2002, Peer-reviewed
      • Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: Analysis of strains isolated from human blood
        K Nakano; M Matsumura; M Kawaguchi; T Fujiwara; S Sobue; I Nakagawa; S Hamada; T Ooshima
        JOURNAL OF DENTAL RESEARCH, Jun. 2002, Peer-reviewed
      • Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells
        Y Terao; S Kawabata; E Kunitomo; I Nakagawa; S Hamada
        INFECTION AND IMMUNITY, Feb. 2002, Peer-reviewed
      • Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells
        I Nakagawa; A Amano; M Kuboniwa; T Nakamura; S Kawabata; S Hamada
        INFECTION AND IMMUNITY, Jan. 2002, Peer-reviewed
      • Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells
        S Okamoto; S Kawabata; I Nakagawa; S Hamada
        INFECTION AND IMMUNITY, Nov. 2001, Peer-reviewed
      • Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator
        Y Terao; S Kawabata; E Kunitomo; J Murakami; I Nakagawa; S Hamada
        MOLECULAR MICROBIOLOGY, Oct. 2001, Peer-reviewed
      • Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia
        T Fujiwara; K Nakano; M Kawaguchi; T Ooshima; S Sobue; S Kawabata; I Nakagawa; S Hamada
        EUROPEAN JOURNAL OF ORAL SCIENCES, Oct. 2001, Peer-reviewed
      • Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells
        I Nakagawa; M Nakata; S Kawabata; S Hamada
        CELLULAR MICROBIOLOGY, Jun. 2001, Peer-reviewed
      • Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection
        M Kuboniwa; A Amano; S Shizukuishi; I Nakagawa; S Hamada
        INFECTION AND IMMUNITY, May 2001, Peer-reviewed
      • Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress
        A Amano; T Premaraj; M Kuboniwa; I Nakagawa; S Shizukuishi; I Morisaki; S Hamada
        ORAL MICROBIOLOGY AND IMMUNOLOGY, Apr. 2001, Peer-reviewed
      • Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome
        A Amano; T Kishima; S Akiyama; I Nakagawa; S Hamada; I Morisaki
        JOURNAL OF PERIODONTOLOGY, Mar. 2001, Peer-reviewed
      • Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice
        S Kawabata; E Kunitomo; Y Terao; I Nakagawa; K Kikuchi; KI Totsuka; S Hamada
        INFECTION AND IMMUNITY, Feb. 2001, Peer-reviewed
      • Molecular cloning, sequence, and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene.
        S Kawabata; Y Terao; I Nakagawa; S Hamada
        Oral Microbiology and Immunology, Dec. 2000, Peer-reviewed
      • Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status
        A Amano; M Kuboniwa; I Nakagawa; S Akiyama; I Morisaki; S Hamada
        JOURNAL OF DENTAL RESEARCH, Sep. 2000, Peer-reviewed
      • Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
        I Nakagawa; A Amano; RK Kimura; T Nakamura; S Kawabata; S Hamada
        JOURNAL OF CLINICAL MICROBIOLOGY, May 2000, Peer-reviewed
      • CD14-dependent and independent pathways in lipopolysaccharide-induced activation of a murine B-cell line, CH12.LX
        S Kimura; T Tamamura; I Nakagawa; T Koga; T Fujiwara; S Hamada
        SCANDINAVIAN JOURNAL OF IMMUNOLOGY, Apr. 2000, Peer-reviewed
      • Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice
        S Kawabata; Y Terao; T Fujiwara; I Nakagawa; S Hamada
        INFECTION AND IMMUNITY, Nov. 1999, Peer-reviewed
      • Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells
        I Nakagawa; M Nakata; S Kawabata; S Hamada
        MOLECULAR MICROBIOLOGY, Sep. 1999, Peer-reviewed
      • Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis
        M Kontani; A Amano; T Nakamura; I Nakagawa; S Kawabata; S Hamada
        INFECTION AND IMMUNITY, Sep. 1999, Peer-reviewed
      • Capsular hyaluronic acid of Group A Streptococci hampers their invasion into human pharyngeal epithelial cells
        S Kawabata; H Kuwata; I Nakagawa; S Morimatsu; K Sano; S Hamada
        MICROBIAL PATHOGENESIS, Aug. 1999, Peer-reviewed
      • Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins
        T Nakamura; A Amano; I Nakagawa; S Hamada
        FEMS MICROBIOLOGY LETTERS, Jun. 1999, Peer-reviewed
      • Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: Kinetic analyses based on surface plasmon resonance
        A Amano; T Nakamura; S Kimura; I Morisaki; I Nakagawa; S Kawabata; S Hamada
        INFECTION AND IMMUNITY, May 1999, Peer-reviewed
      • Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients
        A Amano; I Nakagawa; K Kataoka; I Morisaki; S Hamada
        JOURNAL OF CLINICAL MICROBIOLOGY, May 1999, Peer-reviewed
      • Studying initial phase of biofllm formation: Molecular interaction of host proteins and bacterial surface components
        A Amano; I Nakagawa; S Hamada
        Methods in Enzymology, 1999, Peer-reviewed
      • Studying initial phase of biofilm formation: Molecular interaction of host proteins and bacterial surface components
        A Amano; I Nakagawa; S Hamada
        BIOFILMS, 1999, Peer-reviewed
      • Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor
        A Takemura; N Matsuda; S Kimura; T Fujiwara; I Nakagawa; S Hamada
        JOURNAL OF PERIODONTAL RESEARCH, Oct. 1998, Peer-reviewed
      • The importance of fimbriae in the virulence and ecology of some oral bacteria
        S Hamada; A Amano; S Kimura; I Nakagawa; S Kawabata; I Morisaki
        ORAL MICROBIOLOGY AND IMMUNOLOGY, Jun. 1998, Peer-reviewed
      • Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease
        M Kontani; S Kimura; I Nakagawa; S Hamada
        MOLECULAR MICROBIOLOGY, Jun. 1997, Peer-reviewed
      • Role of alpha beta T cells and gamma delta T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption
        I Takahashi; I Nakagawa; L Xu; S Hamada
        JOURNAL OF PERIODONTAL RESEARCH, Nov. 1996, Peer-reviewed
      • Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches
        I Nakagawa; I Takahashi; H Kiyono; McGhee, JR; S Hamada
        JOURNAL OF INFECTIOUS DISEASES, Jun. 1996, Peer-reviewed
      • Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin
        I Takahashi; M Marinaro; H Kiyono; RJ Jackson; I Nakagawa; K Fujihashi; S Hamada; JD Clements; KL Bost; McGhee, JR
        JOURNAL OF INFECTIOUS DISEASES, Mar. 1996, Peer-reviewed
      • IL-12 RESCUES GALACTOSAMINE-LOADED MICE FROM LETHAL SHOCK TRIGGERED BY STAPHYLOCOCCAL-ENTEROTOXIN
        I TAKAHASHI; I NAKAGAWA; LH XU; S HAMADA
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1995, Peer-reviewed
      • MUCOSAL T-CELLS INDUCE SYSTEMIC ANERGY FOR ORAL TOLERANCE
        I TAKAHASHI; I NAKAGAWA; H KIYONO; MCGHEE, JR; JD CLEMENTS; S HAMADA
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1995, Peer-reviewed
      • INCONSISTENCY BETWEEN THE FIMBRILIN GENE AND THE ANTIGENICITY OF LIPOPOLYSACCHARIDES IN SELECTED STRAINS OF PORPHYROMONAS-GINGIVALIS
        T FUJIWARA; I NAKAGAWA; S MORISHIMA; I TAKAHASHI; S HAMADA
        FEMS MICROBIOLOGY LETTERS, Dec. 1994, Peer-reviewed
      • MOLECULAR AND IMMUNOLOGICAL CHARACTERIZATION OF THE FIMBRIAE OF PORPHYROMONAS-GINGIVALIS
        S HAMADA; T FUJIWARA; S MORISHIMA; I TAKAHASHI; I NAKAGAWA; S KIMURA; T OGAWA
        MICROBIOLOGY AND IMMUNOLOGY, 1994, Peer-reviewed
      • LPS OF ORAL BACTEROIDES SPECIES - GENERAL-PROPERTIES AND INDUCTION OF CYTOKINES IN HUMAN GINGIVAL FIBROBLAST-CULTURES
        S HAMADA; H TAKADA; J MIHARA; I NAKAGAWA; T FUJIWARA
        CELLULAR AND MOLECULAR ASPECTS OF ENDOTOXIN REACTIONS, 1990, Peer-reviewed
      • ミコバクテリア症の定量的細菌リスク評価のための用量依存応答モデルの開発(Development of dose-response models for quantitative microbial risk assessment of mycobacteriosis)
        伊藤 寿宏; 大屋 賢司; 岩本 朋忠; 西内 由紀子; 中川 一路; 丸山 史人
        日本細菌学雑誌, Feb. 2018
      • 豚レンサ球菌(Streptococcus suis)感染ルート解明のための養豚場内細菌叢調査
        Kim Hyunjung; 新井 沙倉; 村瀬 一典; 渡辺 孝康; 黒木 香澄; 丸山 史人; 遠矢 真理; 鈴木 詠律子; 竹下 奈知子; 中川 一路; 大澤 朗; 関崎 勉
        日本細菌学雑誌, Feb. 2018
      • Streptococcus suisのヒト及びブタ細胞における細胞毒性およびオートファジー誘導に関する検討
        黒木 香澄; 野澤 孝志; 渡辺 孝康; Kim Hyunjung; 鈴木 詠律子; 中川 一路; 関崎 勉
        日本細菌学雑誌, Feb. 2018
      • 次世代シーケンサーを用いたBCG Tokyo 172のシードロットおよび市販ロットにおけるヘテロ変異検出
        和田 崇之; 岩本 朋忠; 前田 伸司; 山本 太郎; 山本 三郎; 大原 直也; 中川 一路; 丸山 史人
        結核, Mar. 2016
      • 次世代シーケンサーによるBCGワクチンのシードロットと市販ロットにおけるヘテロ変異の検出
        和田 崇之; 丸山 史人; 岩本 朋忠; 山本 太郎; 中川 一路; 山本 三郎; 大原 直也
        日本細菌学雑誌, Feb. 2016
      • 微生物学の進歩 オートファジーによる防御システム:細胞内の細菌排除機構
        中川 一路
        日本細菌学雑誌, 2005

      Misc.

      • デンタルインプラントの口腔内露出後に生じる周囲細菌叢の経時変化
        下岸 将博; 渡辺 孝康; 柴崎 真樹; 中野 善夫; 春日井 昇平; 中川 一路
        日本細菌学雑誌, Jan. 2020, Peer-reviewed
      • 16S rRNA gene analysis for dental plaque microbiota of cleft lip and/or palate patients
        Muramoto K; Watanabe T; Shiba T; Funahashi K; Ogawa T; Nakagawa I; Moriyama K
        Orthod Waves Jpn Ed, Mar. 2019, Peer-reviewed
      • 潜在期結核菌抗原の精製と感染診断への応用
        大原 由貴子; 尾関 百合子; 立石 善隆; 西山 晃史; 山本 三郎; 中川 一路; 松本 壮吉
        日本細菌学雑誌, Feb. 2018
      • 口唇口蓋裂患者におけるデンタルプラーク細菌叢のメタトランスクリプトーム解析
        舩橋健太; 渡辺孝康; 芝多佳彦; 村本慶子; 小川卓也; 中川一路; 竹内康雄; 和泉雄一; 森山啓司
        Journal of Oral Biosciences Supplement (Web), Sep. 2017
      • インプラント周囲炎と歯周炎の細菌学的な違いを科学する
        芝多佳彦; 竹内康雄; 渡辺孝康; 小柳達郎; 丸山緑子; 加地博一; 村瀬一典; 丸山史人; 中川一路; 和泉雄一
        歯界展望, May 2017
      • 潜在期結核菌抗原の精製と感染診断への応用(Significance of the histone-like protein with the native structure for diagnosis of asymptomatic tuberculosis)
        西田 由貴子; 尾関 百合子; 立石 善隆; 西山 晃史; 山本 三郎; 中川 一路; 松本 壮吉
        日本細菌学雑誌, Feb. 2017
      • 細菌叢遺伝子発現解析によるインプラント周囲炎および歯周炎の疾患特異的な細菌ネットワーク
        渡辺孝康; 芝多佳彦; 加地博一; 村瀬一典; 竹内康雄; 丸山史人; 和泉雄一; 中川一路
        日本細菌学雑誌(Web), Feb. 2017
      • 種内相互組み換えによって促進される鳥型結核菌の地域適応
        矢野大和; 丸山史人; 西内由紀子; 中川一路; 中島千絵; 鈴木定彦; 岩本朋忠
        日本ゲノム微生物学会年会要旨集, 2017
      • HLAクラスI認識受容体群LILRの新展開 病原微生物によって壊された抗体を認識する生体防御機構
        平安 恒幸; 齋藤 史路; 末永 忠広; 信田 京子; 荒瀬 規子; 及川 敬太; 山岡 俊文; 室田 浩之; 知花 博治; 中川 一路; 久堀 智子; 永井 宏樹; 中丸 裕爾; 片山 一朗; Colonna Marco; 荒瀬 尚
        MHC: Major Histocompatibility Complex, Oct. 2016
      • インプラント周囲炎と歯周炎における細菌叢メタトランスクリプトーム解析
        渡辺 孝康; 芝 多佳彦; 加地 博一; 竹内 康雄; 丸山 史人; 和泉 雄一; 中川 一路
        Journal of Oral Biosciences Supplement, Sep. 2016
      • 類似した臨床症状を呈する複合感染症から紐解く恒常性維持機構
        芝 多佳彦; 渡辺 孝康; 小柳 達郎; 丸山 緑子; 竹内 康雄; 丸山 史人; 中川 一路; 和泉 雄一
        日本歯周病学会会誌, Apr. 2016
      • Highlighting genome evolution by a novel acquired immunity system in prokaryotes
        Watanabe T; Murase K; Nakagawa I; Maruyama F
        Antibiotics & Chemotherapy, Nov. 2015
      • CRISPR/Cas システム: 微生物における新規機能とゲノム編集適用例
        相川知宏; 丸山史人; 中川一路
        日本乳酸菌学会誌, 2015
      • インプラント周囲炎および歯周炎罹患部位の細菌群集比較を通じた周囲炎原因候補種と機能遺伝子の選定
        芝 多佳彦; 丸山 史人; 竹内 康雄; 渡辺 孝康; 小柳 達郎; 和泉 雄一; 中川 一路
        日本細菌学雑誌, Feb. 2014
      • 8-Nitro-cGMP: an endogenous regulator of antibacterial autophagy
        Ito Chiaki; Saito Yohei; Nozawa Takashi; Fujii Shigemoto; Hashimoto Ryota; Sawa Tomohiro; Akaike Takaaki; Nakagawa Ichiro; Hirokazu Arimoto
        Symposium on the Chemistry of Natural Products, symposium papers, 2014
      • 原核生物の新規な獲得免疫機構CRISPR/Casシステム
        渡辺孝康; 中川一路; 丸山史人
        化学と生物, Jul. 2013
      • 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】オートファジー-リソソーム/液胞系 オードファジーの生理的役割 感染防御機構としてのオートファジー
        中川 一路; 吉森 保
        蛋白質・核酸・酵素, Aug. 2006
      • オートファジーが病原性細菌を殺す
        中川 一路; 吉森 保
        細胞工学, Dec. 2004
      • Effect of gingipain on RANKL expression by osteoblasts
        N. Okahashi; M. Kuboniwa; I. Nakagawa; K. Nakayama; A. Amano
        Jpn. J. Bacteriol. 59:85, Apr. 2004
      • Virulence of P-gingivalis strains with distinct fimA genotypes.
        K. Nakano; I. Nakagawa; M. Kuboniwa; N. Okahashi; T. Ooshima; A. Amano
        JOURNAL OF DENTAL RESEARCH, Jun. 2003
      • RANKL expression of mouse osteoblasts infected with P. gingivalis
        N. Okahashi; H. Inaba; I. Nakagawa; T. Yamamura; A. Amano; S. Hamada
        Jpn. J. Bacteriol. 58:283, Apr. 2003
      • Induction of septic arthritis by group A streptococcus
        A. Sakurai; N. Okahashi; I. Nakagawa; S. Kawabata; T. Ooshima; S. Hamada
        Jpn. J. Bacteriol. 57:, Apr. 2002
      • RANKL expression on osteoblasts infected with group A strepcotoccus
        N. Okahashi; A. Sakurai; I. Nakagawa; T. Fujiwara; S. Kawabata; A. Amano; S. Hamada
        Jpn. J. Bacteriol. 57:, Mar. 2002
      • kgpDNAワクチンにより誘導される特異抗体はP. gingivalisの鉄獲得を阻害する
        久保庭 雅恵; 天野 敦雄; 中川 一路; 浜田 茂幸
        歯科基礎医学会雑誌, 30 Aug. 2000
      • A群レンサ球菌の咽頭部上皮細胞HEp‐2への付着・侵入とヒアルロン酸の関与 第45回大阪大学歯学会総会
        桑田啓貴; 川端重忠; 中川一路; 浜田茂幸
        大阪大学歯学雑誌, 10 Aug. 1999
      • GAMMA-DELTA-T-CELLS SUSTAIN INFECTIOUS IMMUNITY TO PERIODONTAL BACTERIA IN MICE
        TAKAHASHI, I; NAKAGAWA, I; A DEGUCHI; S HAMADA
        JOURNAL OF DENTAL RESEARCH, 1995
      • Compositional change of peri-implant microbiota after the implant placement
        下岸将博; 渡辺孝康; 柴崎真樹; 中野善夫; 春日井昇平; 中川一路
        日本細菌学雑誌(Web), 2020
      • 化膿連鎖球菌の金属獲得蛋白質MtsAに対する機能阻害剤の探索
        竹内美結; 中木戸誠; 長門石曉; 河出来時; 相川知宏; 中川一路; 津本浩平; 津本浩平; 津本浩平
        日本生化学会大会(Web), 2020
      • Strategy to develop small molecule and antibody-based inhibitors relying on biophysical techniques
        中木戸誠; 相川知宏; 長門石曉; 妹尾暁暢; 竹内美結; 星野将人; 下村拓矢; CAAVEIRO Jose M. M.; 中川一路; 津本浩平; 津本浩平
        日本細菌学雑誌(Web), 2020
      • 分子間相互作用阻害に基づく菌種特異的な増殖阻害剤の開発
        中川一路; 相川知宏; 妹尾暁暢; 中木戸誠; 長門石暁; 津本浩平; 津本浩平
        日本生化学会大会(Web), 2019
      • Porphyromonas属ゲノムにおけるCRISPRと免疫対象の探索
        渡辺孝康; 柴崎真樹; 関崎勉; 中川一路
        日本細菌学雑誌(Web), 2018
      • 時空間的に異なる猩紅熱の流行より採取されたemm12型A群レンサ球菌株における遺伝子変異の探索
        柴崎真樹; 渡辺孝康; 春日井昇平; 中川一路
        日本細菌学雑誌(Web), 2018
      • 化膿連鎖球菌の鉄獲得機構を阻害する新規低分子・抗体の取得
        妹尾暁暢; 星野将人; 中木戸誠; 長門石曉; 長門石曉; 相川知宏; 中川一路; 津本浩平; 津本浩平
        日本生化学会大会(Web), 2018
      • 病原性微生物における鉄獲得関連蛋白質の物理化学解析と新規抗菌剤の探索
        中木戸誠; 妹尾暁暢; VALENCIANO Sandra; 星野将人; 相川知宏; 長門石曉; 長門石曉; CAAVEIRO Jose; 中川一路; 津本浩平; 津本浩平
        日本生化学会大会(Web), 2018
      • emm12型A群レンサ球菌のタンパク質コード領域における一塩基多型の分布
        柴崎真樹; 渡辺孝康; 中川一路; 春日井昇平
        Journal of Oral Biosciences Supplement (Web), 2017
      • Porphyromonas属内におけるCRISPRと免疫対象の関係
        渡辺孝康; 柴崎真樹; 中川一路
        Journal of Oral Biosciences Supplement (Web), 2017
      • Identification of novel inhibitor for Group A Streptococcus growth
        相川知宏; 星野将人; 長門石曉; 津本浩平; 中川一路
        日本細菌学雑誌(Web), 2017
      • CRISPR-プロファージ相互作用解析から見出されたA群レンサ球菌のゲノム進化機構
        山田俊介; 柴崎真樹; 渡辺孝康; 相川知宏; 野澤孝志; 丸山史人; 中川一路
        日本細菌学雑誌, 2015
      • P25-42 CRISPRを保有するバクテリオファージの系統学的普遍性(ポスター発表)
        渡辺 孝康; 野澤 孝志; 丸山 史人; 中川 一路
        日本微生物生態学会講演要旨集, 2014
      • 細胞内寄生を介したA群連鎖球菌の多様化・進化機構の解明
        山田俊介; 柴崎真樹; 渡辺孝康; 丸山史人; 丸山史人; 中川一路
        日本ゲノム微生物学会年会要旨集, 2014
      • PN-002 歯周病原細菌ゲノム情報から紐解く種の維持と共生機構(遺伝学・遺伝子伝播,ポスター発表)
        遠藤 亜希子; 渡辺 孝康; 丸山 史人; 和泉 雄一; 中川 一路
        日本微生物生態学会講演要旨集, 2013
      • PB-063 養殖環境由来薬剤耐性伝達性プラスミドの比較解析(PB 遺伝子伝播,ポスター発表)
        野中 里佐; 丸山 史人; 小椋 義俊; 林 哲也; 中川 一路; 増田 道明
        日本微生物生態学会講演要旨集, 2011

      Awards

      • 20 Mar. 1998
        Japanese Sciety for Bacteriology, 黒屋奨励賞
      • 15 Apr. 1998
        The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, The Young Scientists' Prize

      External funds: Kakenhi

      • 細菌の多彩な病原性を操るポピュレーションダイナミクスと新規エピゲノム制御の探索
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 49:Pathology, infection/immunology, and related fields
        Kyoto University
        中川 一路
        From 09 Jul. 2021, To 31 Mar. 2023, Granted
        A群レンサ球菌;メチル化;ポピュレーションダイナミクス;高病原化
      • Clarification of virulence factor involved in the chronicity of osteomyelitis of the jaw
        Grant-in-Aid for Scientific Research (C)
        Basic Section 57060:Surgical dentistry-related
        Tokyo Medical and Dental University
        道 泰之
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        顎骨骨髄炎;メタトランスクリプトーム解析;細菌叢;プロテオーム解析;複合感染症
      • 皮膚微小環境において極小マイクロバイオームが果たす役割の解明
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53050:Dermatology-related
        Kyoto University
        中島 沙恵子
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        皮膚マイクロバイオーム;極小マイクロバイオーム;レーザーキャプチャーマイクロダイセクション
      • Nutrient Immunityに対抗する細菌の金属輸送系の進化と機能解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        中川 一路
        From 01 Apr. 2020, To 31 Mar. 2022, Granted
        細菌;適応;金属獲得;創薬ターゲット;nutrient immunity;A群連鎖球菌;金属輸送系;AdcA;亜鉛;マンガン;鉄
      • 細菌種特異的ゼノファジーを誘導するRab制御系ネットワークの解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        中川 一路
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        ゼノファジー;A群レンサ球菌;黄色ブドウ球菌;RabGAP;RabGEF;オートファジー;SLO;Nga;ゴルジ体;上皮間接着;TBC1D9;細胞内カルシウム
      • Conprehensive functional analyses of cell-wall proteins of Streptococcus suis
        Grant-in-Aid for Scientific Research (B)
        Basic Section 42020:Veterinary medical science-related
        Kyoto University;The University of Tokyo
        関崎 勉
        From 01 Apr. 2019, To 31 Mar. 2023, Granted
        豚レンサ球菌;病原性;細胞壁結合蛋白質;遺伝子破壊株;網羅的機能解析;細胞壁タンパク質
      • 薬剤耐性菌の出現抑制を目的とした豚レンサ球菌感染症の新規診断・治療法の基盤開発
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 42:Veterinary medical science, animal science, and related fields
        Kyoto University
        中川 一路
        From 09 Oct. 2018, To 31 Mar. 2022, Granted
        ブタレンサ球菌;抗原;ブタ血清;単分子抗体;質量分析;抗体;豚レンサ球菌;血清;IgG;薬剤耐性;人工抗体;ファージディスプレイ
      • 口腔インプラントの脱落要因を探る:インプラント周囲細菌叢の時空間的解析
        Grant-in-Aid for Scientific Research (C)
        Basic Section 57040:Regenerative dentistry and dental engineering-related
        Tokyo Medical and Dental University
        下岸 将博
        From 01 Apr. 2018, To 31 Mar. 2022, Granted
        インプラント;感染症;歯科インプラント;細菌叢
      • Development of species-specific anti-bacterial therapeutic agents based on molecular interaction
        Grant-in-Aid for Challenging Research (Exploratory)
        Kyoto University
        ICHIRO NAKAGAWA
        From 30 Jun. 2017, To 31 Mar. 2019, Project Closed
        A群レンサ球菌;鉄獲得系;Shr;ヘム鉄;増殖阻害薬;低分子化合物;スクリーニング;抗体;鉄取り込み;単分子抗体;機能阻害;タンパク質相互作用;細菌感染症;菌種特異的増殖阻害剤;分子間相互作用;分子標的薬
      • 顎骨骨髄炎細菌叢の保有する病原因子の解明と新規治療戦略の提案
        Grant-in-Aid for Scientific Research (C)
        Tokyo Medical and Dental University
        道 泰之
        From 01 Apr. 2017, To 31 Mar. 2020, Granted
        顎骨骨髄炎;細菌叢;メタゲノム;メタトランスクリプトーム;複合感染症;メタゲノム解析;メタ16S解析;細菌性ネットワーク
      • Analysis of collaborative activities between the capsule-positive and capsule-negative Streptococcus suis in the induction of and escape from autophagy
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo
        Tsutomu Sekizaki
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        豚レンサ球菌;オートファジー;莢膜;心内膜炎;感染症;細胞障害性;細胞侵入性;細胞壁タンパク質;オードファジー
      • Validation of microbial safety in drinking water in the world by comparative genomics of Vibrio cholerae
        Grant-in-Aid for Scientific Research (B)
        Hiroshima University;Kyoto University
        Fumito MARUYAMA
        From 01 Apr. 2016, To 31 Mar. 2020, Project Closed
        コレラ;比較ゲノム解析;薬剤耐性;ゲノム疫学;CRISPR;ゲノム;魚病;コレラ菌;海外;フィールド;比較ゲノム;ビブリオ;水圏;生態
      • Elucidation of genomic diversification in Group A Streptococci based on GWAS and epigenome
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        FUMITO MARUYAMA
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        比較ゲノム;進化;多様性;細菌ゲノム;多様化;溶連菌;エピゲノム;GWAS;ゲノム解析;メチローム;トランスクリプトーム;病原性;A群レンサ球菌;ゲノム;細菌;微生物
      • Regulation of xenophagy aginst Group A Streptococcus
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        ICHIRO NAKAGAWA
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        A群レンサ球菌;オートファジー;Rab35;TDC1D10A;ゼノファジー;Rab30;フォスファチジルイノシトール4リン酸;細菌感染;ユビキチン化;Rabタンパク質;A群特異的糖鎖;ユビキチン;アダプター;糖鎖
      • Development of DNA memory device using spacers in CRISPR
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Fumito Maruyama
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        CRISPR;レンサ球菌;比較ゲノム解析;A群レンサ球菌;進化;多様化;病原細菌
      • Visualization of bacteria-induced autophagy by live-imaging.
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        ICHIRO NAKAGAWA
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        A群レンサ球菌;オートファジー;イメージング;Rabタンパク質;ゼノファジー;膜形成
      • Analysis of porcine oral flora dynamics for determining the main cause of developing swine streptococcosis
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        TSUTOMU SEKIZAKI
        From 01 Apr. 2015, To 31 Mar. 2019, Project Closed
        豚レンサ球菌;口腔内細菌叢;微生物動態;メタゲノム解析;感染症
      • Elucidation of the pathogenesis of cleft palate and tooth devevelopment problmes using new molecular technology.
        Grant-in-Aid for Scientific Research (A)
        Osaka University
        Takashi Yamashiro
        From 01 Apr. 2015, To 31 Mar. 2019, Project Closed
        口蓋裂;Runx1;Cbfb;Stat3;Tgfb3;Lgr5;サービカルループ;ゲノム編集;歯学;バイオテクノロジー;発生・分化;口蓋;歯;遺伝子改変動物
      • Clarification of pathological condition of osteomyelitis of the jaw based on the analysis of microbiome network, and proposal of the optimal therapeutic strategy
        Grant-in-Aid for Scientific Research (C)
        Tokyo Medical and Dental University
        Yasuyuki MICHI
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        複合感染症;顎骨骨髄炎;メタ16s解析;メタゲノム解析;メタ16S解析
      • Regulation and reconstruction of acquired memories in human microbiota
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University;Tokyo Medical and Dental University
        Fumito MARUYAMA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        バクテリオファージ;CRISPR;微生物生態学;細菌叢解析;外来因子
      • Development of a new therapeutic method by genome-editing
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University;Tokyo Medical and Dental University
        Ichiro NAKAGAWA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        A群レンサ球菌;CRIPSR;TALEN;ZFN;増殖抑制;A群レンサ球菌;CRISPR;Cas9;ファージ;ゲノム編集;感染制御
      • Establishment of a new prediction medhods of epidemic strains in Group A Streptococcus by CRISPR typing.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University;Tokyo Medical and Dental University
        ICHIRO NAKAGAWA
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        A群レンサ球菌;emmタイピング;CRIPSR;レンサ球菌;ゲノム;莢膜;CRISPR;ブタレンサ球;スペーサー解析;流行予測;国際研究者交流;タイ
      • Analysis of Atg5 dependent and independent autophagy and induction mechanism of inflammation during bacterial infection.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University;Tokyo Medical and Dental University
        ICHIRO NAKAGAWA
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        A群レンサ球菌;xenophagy;オートファジー;Rabタンパク質;炎症;Rab30;Rab9;Rab23;Rab17;認識分子;炎症誘導;Atg5
      • A群レンサ球菌の感染細胞内でのファージを介したゲノムアダプテーション
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University;Tokyo Medical and Dental University
        中川 一路
        From 28 Jun. 2013, To 31 Mar. 2015, Project Closed
        A群レンサ球菌;ファージ;CRISPR;進化;ゲノム;溶原化
      • Analysis of microbiota and its function associated with peri-implantitis using next generation sequencing technology
        Grant-in-Aid for Young Scientists (B)
        Tokyo Medical and Dental University
        Yasuo TAKEUCHI
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        インプラント周囲炎;歯周病原細菌;次世代シークエンシング;polymicrobial disease;トランスクリプトーム;インプラント;歯周炎;細菌
      • Novel functions of Runx genes as causal genes for ectodermal dysplasia
        Grant-in-Aid for Scientific Research (A)
        Osaka University;Okayama University
        Takashi Yamashiro
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        Runxシグナリング;上皮間葉相互作用;器官形成;Cbfb;Runx1;唾液腺;歯;皮膚付属器官;Cbfb;切歯;臼歯
      • The new paradigm to search the bioscientific mechanism of malocclusion
        Grant-in-Aid for Challenging Exploratory Research
        Okayama University
        Takashi YAMASHIRO
        Project Closed
        不正咬合;エピジェネティクス;分子機構;実験的歯の移動モデル;クロマチン;マイクロアレイ;実験的不正咬合モデル
      • Maintenance mechanism of oral homeostasis revealed by fine scale analysis of microbiota
        Grant-in-Aid for Scientific Research (C)
        Tokyo Medical and Dental University
        Fumito MARUYAMA
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        細菌叢;新型シーケンサー;恒常性;口腔細菌叢;細菌ゲノム;高速シーケンサー
      • The elucidation of molecular mechanisms of amelogenesis by epitherial-specific Runx knockout mouse
        Grant-in-Aid for Scientific Research (B)
        Tottori University;Okayama University
        Tadashi HONJO
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        Runx1, Cbfb;エナメル芽細胞;遺伝子改変動物;エナメル質;Runxシグナリング;Runx1;Cbvb;cbfb;runx1;Runx;Cbfb;歯原性上皮
      • The possible role of autophagy in craniofacial development
        Grant-in-Aid for Scientific Research (B)
        Okayama University
        Takashi YAMASHIRO
        Project Closed
        オートファジー;口蓋の形成;口蓋突起;骨組織;ERストレス;ATG5;LC3;小胞体ストレス;口唇口蓋裂;骨形成;口蓋;顎顔面;骨格;骨芽細胞
      • レンサ球菌属における種特異的ゲノム進化機構の解明
        Grant-in-Aid for Scientific Research (B)
        Tokyo Medical and Dental University
        中川 一路
        Project Closed
        A群レンサ球菌;S.mutans;ファージ;進化;再構成;CRISPR;レンサ球菌;Streptococcus mutans;バクテリオファージ;グノム再構成
      • 新規遺伝子獲得の可視化によるA群レンサ球菌の病原性発現機構の解析
        Grant-in-Aid for Challenging Exploratory Research
        Osaka University;Nihon University
        浜田 茂幸
        Project Closed
        レンサ球菌;A群レンサ球菌;Streptococcus mutans;バクテリオファージ;CRISPR;ゲノム再構成;マイクロアレイ;タイリングアレイ;転写;GFP
      • Tiling array analysis of transcriptional regulators in genus Streptococcus
        Grant-in-Aid for Scientific Research (B)
        Nihon University
        Shigeyuki HAMADA
        Project Closed
        レンサ球菌;マイクロアレイ;タイリングアレイ;遺伝子発現;A群レンサ球菌;non-coding RNA;転写調節;感染
      • Induction mechanism of Inflammation and autophagy by group A Streptococcus infection
        Grant-in-Aid for Scientific Research (B)
        The University of Tokyo
        Ichiro NAKAGAWA
        Project Closed
        A 群レンサ球菌;細胞内侵入性;菌体成分;炎症反応;オートファジー;A群レンサ球菌;炎症惹起;Nod1;Nod2;炎症;Nod like receptor;分解
      • Analysis of virulence factors in cariogenic bacteria for cardiovascular diseases
        Grant-in-Aid for Scientific Research (A)
        Osaka University
        Takashi OOSHIMA
        Project Closed
        Streptococcus mutans;う蝕;全身疾患;循環器疾患;コラーゲン結合タンパク;血清型;感染性心内膜炎;心臓弁;血小板凝集;疣贅;グルコシルトランスフェラーゼ;大動脈瘤;分子生物学;菌休表層タンパク;ゲノム解析
      • 細胞内侵入性細菌に対する細胞内認識システムとオートファジー誘導の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        中川 一路
        Project Closed
        オートファジー;A群レンサ球菌;炎症惹起;Nod1;Nod2;菌体成分;ペプチドグリカン;マイクロインジェクション;Nod like receptor
      • NODファミリー分子によるA群レンサ球菌の認識とオートファジー誘導の動態解析
        Grant-in-Aid for Exploratory Research
        Nihon University
        浜田 茂幸
        Project Closed
        A群レンサ球菌;オートファジー;Nod Like receptor;Nod2;グラム陽性菌;細胞壁;ペプチドグリカン;NODファミリー;アポトーシス;感染症
      • 細菌感染によるオートファジー誘導の分子機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Osaka University
        天野 敦雄
        Project Closed
        歯学;細菌;感染症;細胞・組織;シグナル伝達;オートファジー;A群レンサ球菌;細胞内侵入細菌;自然免疫システム;Nod-like receptor
      • Analysis of host defense system against pathogenic oral bacteria in oral epithelial cells by the intracellular PAMPs receptors
        Grant-in-Aid for Scientific Research (C)
        Tokyo University;Osaka University
        Ichiro NAKAGAWA
        Project Closed
        A群レンサ球菌;オートファジー;菌体成分認識;miR-RNAi;ノックダウン;Nalp;NLRファミリー;P. gingivalis;侵入;エンドサイトーシス;インテグリン;ラフト, Group A Streptococcus;autophagy;recognition receptor;miR-RNAi;knockdown;Nalp
      • Analysis of the relationship of periodontal susceptibility to periodontal dicease with bactericidal activity against P. gingivalis by periodontal epithelial cells
        Grant-in-Aid for Scientific Research (B)
        Osaka University
        Atsuo AMANO
        Project Closed
        歯学;細菌;感染症;細胞・組織;シグナル伝達;Porphyromonas gingivalis;細胞内侵入細菌;歯周病;リピッドラフト;エンドサイトーシス;マイクロアレイ;dynamin, Dentistry;Bacteria;Infection;Cell・tissue;Signal transduction
      • Molecular analysis of the developmental mechanism of periodontal and oral diseases by the genome analysis of oral biofilm.
        Grant-in-Aid for Scientific Research (B)
        Nihon University
        Shigeyuki HAMADA
        Project Closed
        P.gingivalis;線毛;vesicle;S.mutans;糖鎖;ゲノム;Multilocus sequencing, Porpyromonas gingival is;fimbriae;vesicle;Streptococcus mutans;glucose side chain;genome;Multilocus sequencing typing
      • Analysis in pathogenesis of bacterial lethal soft-tissue infection and application to prevention and therapy.
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kanazawa University
        Tohru SHIMIZU
        Project Closed
        細菌感染症;ゲノム解析;トランスクリプトーム;遺伝子発現制御;病原性;ウェルシュ菌;A群レンサ球菌;マイクロアレイ;遺伝子発現調節;オートファジー;遺伝子発現解析;二成分制御系;オートインデューサー;細胞壁;細胞内寄生性細菌;DNAマイクロアレイ;エンドサイトーシス;ストレプトリジンO
      • Induction of inflammatory immune response by streptococcal water-insoluble α-glucans and association with periodontal diseases
        Grant-in-Aid for Scientific Research (C)
        Fukuoka Dental College
        Shigefumi OKAMOTO
        Project Closed
        不溶性グルカン;マクロファージ;好中球;炎症性サイトカイン;遊走能;活性酸素;レンサ球菌;免疫応答, Steptococcus sobrinus;water-insoluble α-glucans;inflammatory immune responses;periodontal diseases
      • Molecular analysis of cell surface structures of Streptococcus mutans for virulence of infective endocarditis
        Grant-in-Aid for Scientific Research (B)
        Osaka University
        Takashi OOSHIMA
        Project Closed
        感染性心内膜炎;Streptococcus mutans;心臓弁;疣贅;デンタルプラーク;PCR法;血清型;グルコシルトランスフェラー;血清型特異多糖抗原;Protein antigen c;多型核白血球;貪食作用;食作用, infective endocarditis;Streptococcus mutants;heart valve;vegetation;dental plaque;PCR;serotype
      • Molecular mimic of group A streptococcal surface proteins
        Grant-in-Aid for Scientific Research (B)
        Osaka University
        Shigetada KAWABATA
        Project Closed
        A群レンサ球菌;咽頭炎;フィブロネクチン;交叉反応;感染防御抗原;コラーゲン;ケラチン;S.pyogenes;分子擬態;免疫;タンパク質;食細胞, Streptococcus pyogenes;vaccine;fibronectin;invasion;antibody;collagen
      • 細胞内侵入性細菌に対する細胞内認識システムとオートファジー誘導の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Osaka University
        天野 敦雄
        Project Closed
        オートファジー;A群レンサ球菌;細胞内侵入細菌;自然免疫システム
      • 歯周病原性細菌の宿主細胞内侵入と歯周組織破壊機構の分子生物学的解析
        Grant-in-Aid for Young Scientists (B)
        Osaka University
        中川 一路
        Project Closed
        歯周病原性細菌;Porphyromonas gingivalis;付着;定着;インテグリン;CHO細胞;フィブロネクチン;ビトロネクチン;歯周病;P.gingivalis;RANKL;AP-1
      • Inhibition of tissue-reparing signaling by P.gingivalis infection
        Grant-in-Aid for Scientific Research (B)
        Osaka University
        Nobuo OKAHASHI
        Project Closed
        歯周病;再生医学;P.gingivalis;細胞接着;上皮細胞;歯根膜細胞;骨芽細胞, periodontitis;tissue regeneration;P.gingivalis;cellular attachment;epithelial cells;periodontal ligament cells
      • Characterization of surface proteins on cell invasion of streptococcus pyogenes
        Grant-in-Aid for Scientific Research (B)
        Osaka University
        Shigetada KAWABATA
        Project Closed
        S.pyogenes;侵入;表層タンパク;フィブロネクチン;結合;Streptococcus pyogenes;細胞侵入;細胞付着;遺伝子;ワクチン;ゲノム;劇症型レンサ球菌感染症;Streptococuus pyogenes;付着, S.pyogenes;invasion;surface protein;fibronectin;pinding
      • Molecular analysis of streptococcal infections diseases by the functional genomics.
        Grant-in-Aid for Scientific Research (A)
        Osaka University
        Shigeyuki HAMADA
        Project Closed
        A群レンサ球菌;劇症化;ゲノム解析;フィブロネクチン結合タンパク;インフルエンザ;遺伝子発現;ヒアルロン酸;オートファジー;付着;侵入;エンドサイトーシス;分解;Streptococcus pyogenes;全ゲノム配列;リアレンジメント;ファージ;ゲノム再構成;ゲノム進化;比較ゲノム解析, group A Streptcoccus;severe invasive diseases;genome analysis;fibronectin binding protein;influenza;gene expression;hyaluronic acid;autophagy
      • Development of clinical diagnostic test and DNA vaccination based on genotypes of the periodontal pathogen
        Grant-in-Aid for Scientific Research (B)
        OSAKA UNIVERSITY
        Atsuo AMANO
        Project Closed
        歯周病;Porphyromonas gingivalis;遺伝子型;遺伝子タイピング;DNAワクチン;Polymerase chain reaction;線毛;fimA;遺伝子多型;線毛遺伝子fimA;遺伝子診断;遺伝子診断法;ヒト上皮細胞, Porphyromonas gingivalis;Genotype;Genotyping;DNA vaccine;Polymerase chain reaction;fimbriae;fimA
      • レンサ球菌に対するオプソニン効果を有する免疫グロブリン融合タンパクの開発
        Grant-in-Aid for Exploratory Research
        Osaka University
        浜田 茂幸
        Project Closed
        ファイブロネクチン;Fc融合タンパク;細菌感染;オプソニン;A群レンサ球菌;フィブロネクチン;CD44;COS細胞;CD44-Fc;Fib-Fc
      • 大腸菌ベロ毒素Bサブユニットによる細胞機能の阻害メカニズムの解析
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Osaka University
        中川 一路
        Project Closed
        アポトーシス;上皮細胞;細菌感染;カスパーゼ;Stx;Bサブユニット;テトラサイクリン誘導プロモーター
      • Induction of mucosal immune responses by DNA vaccine encoding Porphyromonas gingivalis fimbriae
        Grant-in-Aid for Scientific Research (C)
        Osaka University
        Shigetada KAWABATA
        Project Closed
        歯周病;Porphyromanas gingivalis;線毛;DNAワクチン;粘膜免疫;IgA;Porphyromonas gingivalis;DNA ワクチン;顎下腺, Periodontal Diseases;Porphyromonas gingivalis;fimbriae;DNA Vaccine;Mucosal Immunity;IgA
      • Molecular analyses on Streptococcus pyogenes adherence to and invasion of pharyngeal epithelial cells
        Grant-in-Aid for Scientific Research (A)
        Osaka University
        Shigeyuki HAMADA
        Project Closed
        A群レンサ球菌;侵入;フィブロネクチン;ワクチン;細胞外マトリックス;ラミニン;細胞付着;フィプロネクチン;細胞マトリックス;体液性免疫;莢膜;ヒアルロン酸;上皮細胞;hasA, Streptococcus pyogenes;Invasion;Fibronectin;Vaccine;Extracellular matrix;Laminin;Adhesion
      • RAP-PCR法を用いた腸管出血性大腸菌感染に対する腸管上皮細胞の発現遺伝子の解析
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Osaka University
        中川 一路
        Project Closed
        志賀毒素Bサブユニット;アポトーシス;カスパーゼ;テトラサイクリン誘導発現系;炎症性サイトカイン;腸管出血性大腸菌;HEp-2;RAP-PCR;DEC1;CD68
      • 菌種特異的に進化した金属特異的レセプターに対する新規創薬基盤の開発
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        中川 一路
        From 01 Apr. 2022, To 31 Mar. 2024, Adopted
      • 細菌糖鎖認識のニューパラダイム:非定型ユビキチン化によるゼノファジー制御の解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        中川 一路
        From 01 Apr. 2022, To 31 Mar. 2025, Adopted

      External funds: others

      • 豚レンサ球菌感染の新規迅速診断法の開発事業 (2019年度分)
        日本中央競馬会畜産振興交付金
        From 26 Apr. 2019, To 31 Mar. 2020
        中川 一路
      • 豚レンサ球菌感染の新規迅速診断法の開発事業 (2020年度分)
        日本中央競馬会畜産振興交付金
        From 01 Apr. 2020, To 31 Mar. 2021
        中川 一路
      • 人工ファージによるSwine PathoScan法の開発事業 (2021年度分)
        日本中央競馬会畜産振興交付金
        From 27 May 2021, To 31 Mar. 2022
        中川 一路
      list
        Last Updated :2022/05/14

        Education

        Teaching subject(s)

        • From Apr. 2014, To Mar. 2015
          Microbiology II
          Spring, 医学研究科
        • From Apr. 2014, To Mar. 2015
          Microbiology I
          Spring, 医学研究科
        • From Apr. 2015, To Mar. 2016
          Microbiology
          Spring, 医学部
        • From Apr. 2015, To Mar. 2016
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2015, To Mar. 2016
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2015, To Mar. 2016
          Laboratory visit
          Spring, 医学研究科
        • From Apr. 2015, To Mar. 2016
          Microbiology II
          Spring, 医学研究科
        • From Apr. 2015, To Mar. 2016
          Microbiology I
          Spring, 医学研究科
        • From Apr. 2016, To Mar. 2017
          Microbiology
          Spring, 医学部
        • From Apr. 2016, To Mar. 2017
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2016, To Mar. 2017
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2016, To Mar. 2017
          Microbiology II
          Spring, 医学研究科
        • From Apr. 2016, To Mar. 2017
          Microbiology I
          Spring, 医学研究科
        • From Apr. 2017, To Mar. 2018
          Microbiology
          Spring, 医学部
        • From Apr. 2017, To Mar. 2018
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2017, To Mar. 2018
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2017, To Mar. 2018
          Microbiology
          Fall, 医学部
        • From Apr. 2017, To Mar. 2018
          Laboratory Course in Microbiology
          Fall, 医学部
        • From Apr. 2017, To Mar. 2018
          Microbiology II
          Fall, 医学研究科
        • From Apr. 2017, To Mar. 2018
          Microbiology I
          Fall, 医学研究科
        • From Apr. 2018, To Mar. 2019
          Microbiology
          Spring, 医学部
        • From Apr. 2018, To Mar. 2019
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2018, To Mar. 2019
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2018, To Mar. 2019
          Microbiology
          Fall, 医学部
        • From Apr. 2018, To Mar. 2019
          Laboratory Course in Microbiology
          Fall, 医学部
        • From Apr. 2018, To Mar. 2019
          Microbiology II
          Fall, 医学研究科
        • From Apr. 2018, To Mar. 2019
          Microbiology I
          Fall, 医学研究科
        • From Apr. 2018, To Mar. 2019
          Infectious disease medicine I
          Fall, 医学部(人間健康科学科)
        • From Apr. 2019, To Mar. 2020
          Microbiology
          Spring, 医学部
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2019, To Mar. 2020
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2019, To Mar. 2020
          Microbiology
          Fall, 医学部
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Microbiology
          Fall, 医学部
        • From Apr. 2019, To Mar. 2020
          Microbiology II
          Fall, 医学研究科
        • From Apr. 2019, To Mar. 2020
          Microbiology I
          Fall, 医学研究科
        • From Apr. 2019, To Mar. 2020
          Infectious disease medicine I
          Fall, 医学部(人間健康科学科)
        • From Apr. 2020, To Mar. 2021
          Microbiology
          Spring, 医学部
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2020, To Mar. 2021
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2020, To Mar. 2021
          Microbiology
          Fall, 医学部
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Microbiology
          Fall, 医学部
        • From Apr. 2020, To Mar. 2021
          Microbiology II
          Fall, 医学研究科
        • From Apr. 2020, To Mar. 2021
          Microbiology I
          Fall, 医学研究科
        • From Apr. 2020, To Mar. 2021
          Infectious disease medicine I
          Fall, 医学部(人間健康科学科)
        • From Apr. 2021, To Mar. 2022
          Microbiology
          Spring, 医学部
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Microbiology
          Spring, 医学部
        • From Apr. 2021, To Mar. 2022
          Medical Parasitology
          Spring, 医学部
        • From Apr. 2021, To Mar. 2022
          Microbiology
          Fall, 医学部
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Microbiology
          Fall, 医学部
        • From Apr. 2021, To Mar. 2022
          Microbiology II
          Fall, 医学研究科
        • From Apr. 2021, To Mar. 2022
          Microbiology I
          Fall, 医学研究科
        • From Apr. 2021, To Mar. 2022
          Infectious disease medicine I
          Fall, 医学部(人間健康科学科)
        list
          Last Updated :2022/05/14

          Administration

          School management (title, position)

          • From 01 Apr. 2017, To 31 Mar. 2021
            組換えDNA実験安全委員会 1号委員
          • From 01 Apr. 2018
            組換えDNA実験安全主任者
          • From 01 Apr. 2018, To 31 Mar. 2020
            入学試験企画・研究専門委員会
          • From 01 Apr. 2019, To 31 Mar. 2021
            組換えDNA実験安全委員会 委員
          • From 01 Oct. 2019
            研究倫理・安全推進委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2021
            組換えDNA実験安全委員会 委員(~2019/9/30)、委員長(2019/10/1~)
          • From 01 Apr. 2021, To 31 Mar. 2023
            組換えDNA実験安全委員会 委員長

          Faculty management (title, position)

          • From 01 Nov. 2014, To 31 Oct. 2018
            期限付特定教員採用審査委員会
          • From 01 Apr. 2017, To 31 Mar. 2019
            医学図書館運営委員会
          • To 30 Sep. 2019
            医学研究科運営委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            学務委員会
          • From 01 Apr. 2017, To 31 Mar. 2021
            入学者選抜方法検討委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            大倉辰三郎・喜美奨学金 選考小委員会
          • From 01 Apr. 2019, To 31 Mar. 2021
            総合博物館協議員会
          • From 01 Oct. 2020, To 30 Sep. 2022
            産学共同講座等検討委員会委員
          • From 01 Oct. 2020, To 31 Mar. 2022
            病原体等安全管理委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2023
            入学者選抜方法検討委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            大倉辰三郎・喜美奨学金選考小委員会委員
          list
            Last Updated :2022/05/14

            Academic, Social Contribution

            Committee Memberships

            • From 2015, To 2020
              理事, 日本細菌学会
            • From 2002
              評議員, 日本細菌学会

            ページ上部へ戻る