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Kondo, Hiroshi

KYOTO UNIVERSITY HOSPITAL Associate Professor

Kondo, Hiroshi
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    Last Updated :2022/09/09

    Basic Information

    Concurrent Affiliation

    • Graduate School of Medicine, 医学研究科 医学専攻

    Academic Degree

    • 博士(医学)(京都大学)

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2022/09/09

      Research

      Research Topics, Overview of the research

      • Research Topics

        Identification of the metabolic regulation involved in ageing and its relevant diseases
      • Overview of the research

        Our main interests are to investigate the mechanistic basis of metabolism relevant to aging and senescence. For this purpose, we are working for tissue culture, mice models, and human metabolome samples.

      Research Areas

      • Life sciences, Internal medicine - General

      Papers

      • RNA-binding proteins: Underestimated contributors in tumorigenesis
        Y. Zhao; C. Mir; Y. Garcia-Mayea; R. Paciucci; H. Kondoh; M.E. LLeonart
        Seminars in Cancer Biology, Feb. 2022
      • Reply to Zheng et al.: Clinical metabolomics: Detailed analysis by nontargeted method is complementary to large-scale studies
        Hiroshi Kondoh; Takayuki Teruya; Yung-Ju Chen; Yasuhide Fukuji; Mitsuhiro Yanagida
        Proceedings of the National Academy of Sciences, Feb. 2022
      • Targeting p21 for diabetes: Another choice of senotherapy
        Hiroshi Kondoh; Eiji Hara
        Cell Metabolism, Jan. 2022
      • Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells.
        Takaaki Murakami; Nobuya Inagaki; Hiroshi Kondoh
        Frontiers in endocrinology, 2022
      • Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer
        Rumi Itoyama; Noriko Yasuda-Yoshihara; Fumimasa Kitamura; Tadahito Yasuda; Luke Bu; Atsuko Yonemura; Tomoyuki Uchihara; Kota Arima; Xichen Hu; Zhang Jun; Yuya Okamoto; Takahiko Akiyama; Kohei Yamashita; Yosuke Nakao; Toshihiko Yusa; Yuki Kitano; Takaaki Higashi; Tatsunori Miyata; Katsunori Imai; Hiromitsu Hayashi; Yo-ichi Yamashita; Takumi Mikawa; Hiroshi Kondoh; Hideo Baba; Takatsugu Ishimoto
        Cancer Letters, Dec. 2021
      • Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites
        Takayuki Teruya; Yung-Ju Chen; Hiroshi Kondoh; Yasuhide Fukuji; Mitsuhiro Yanagida
        Proceedings of the National Academy of Sciences, 14 Sep. 2021
      • 【老年医学(上)-基礎・臨床研究の最新動向-】老化の基礎研究 老化とは
        近藤 祥司; 三河 拓己; 亀田 雅博
        日本臨床, Jun. 2018
      • Cellular Aging and Metabolites in Aging
        Hiroshi Kondoh; Takumi Mikawa; Masahiro Kameda
        Aging Mechanisms II, 2022
      • Decline of ergothioneine in frailty and cognition impairment.
        Hiroshi Kondoh; Takayuki Teruya; Masahiro Kameda; Mitsuhiro Yanagida
        FEBS letters, 28 Jan. 2022
      • Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty
        Masahiro Kameda; Takayuki Teruya; Mitsuhiro Yanagida; Hiroshi Kondoh
        Aging, 07 Sep. 2021
      • Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis
        Takumi Mikawa; Eri Shibata; Midori Shimada; Ken Ito; Tomiko Ito; Hiroaki Kanda; Keiyo Takubo; Atsuyoshi Shimada; Matilde E. Lleonart; Nobuya Inagaki; Masayuki Yokode; Hiroshi Kondoh
        PLOS ONE, 29 Apr. 2021
      • Editorial: How Do Metabolism, Angiogenesis, and Hypoxia Modulate Resistance?
        Hiroshi Kondoh; Josep Castellvi; Matilde Esther LLeonart
        Frontiers in Oncology, 12 Apr. 2021
      • Senescence research from historical theory to future clinical application
        Masahiro Kameda; Takumi Mikawa; Masayuki Yokode; Nobuya Inagaki; Hiroshi Kondoh
        Geriatrics & Gerontology International, Feb. 2021
      • Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment
        Masahiro Kameda; Takayuki Teruya; Mitsuhiro Yanagida; Hiroshi Kondoh
        Proceedings of the National Academy of Sciences, 05 Jan. 2021
      • Efficient and rapid assessment of multiple aspects of frailty using the Kyoto Frailty Scale, developed from the Edmonton Frail Scale
        Masahiro Kameda; Rie Shibata; Hiroshi Kondoh
        Journal of Physical Therapy Science, 2021
      • Whole Blood Metabolomics in Aging Research
        Hiroshi Kondoh; Masahiro Kameda; Mitsuhiro Yanagida
        International Journal of Molecular Sciences, 26 Dec. 2020
      • T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses
        Koji Toriyama; Makoto Kuwahara; Hiroshi Kondoh; Takumi Mikawa; Nobuaki Takemori; Amane Konishi; Toshihiro Yorozuya; Takeshi Yamada; Tomoyoshi Soga; Atsushi Shiraishi; Masakatsu Yamashita
        Communications Biology, Dec. 2020
      • Autophagy Takes Center Stage as a Possible Cancer Hallmark
        Jose G. Alvarez-Meythaler; Yoelsis Garcia-Mayea; Cristina Mir; Hiroshi Kondoh; Matilde E. LLeonart
        Frontiers in Oncology, 22 Oct. 2020
      • Metabolomics of human fasting: new insights about old questions
        Hiroshi Kondoh; Takayuki Teruya; Mitsuhiro Yanagida
        Open Biology, Sep. 2020
      • Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis
        Takumi Mikawa; Eri Shibata; Midori Shimada; Ken Ito; Tomiko Ito; Hiroaki Kanda; Keiyo Takubo; Matilde E. Lleonart; Nobuya Inagaki; Masayuki Yokode; Hiroshi Kondoh
        iScience, Jul. 2020, Peer-reviewed
      • Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility
        Masahiro Kameda; Takayuki Teruya; Mitsuhiro Yanagida; Hiroshi Kondoh
        Proceedings of the National Academy of Sciences, 28 Apr. 2020
      • Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood.
        Takayuki Teruya; Romanas Chaleckis; Junko Takada; Mitsuhiro Yanagida; Hiroshi Kondoh
        Scientific Reports, Jan. 2019, Peer-reviewed
      • The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy
        Juan Lorente; Carolina Velandia; Jose A. Leal; Yoelsis Garcia-Mayea; Alex Lyakhovich; Hiroshi Kondoh; Matilde E. LLeonart
        Biological Reviews, 01 Feb. 2018, Peer-reviewed
      • REPLY TO MAKINEN AND ALA-KORPELA: Small-scale but accurate metabolomics with high reproducibility for identifying age-related blood metabolites
        Hiroshi Kondoh; Mitsuhiro Yanagida
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2016, Peer-reviewed
      • Individual variability in human blood metabolites identifies age-related differences
        Romanas Chaleckis; Itsuo Murakami; Junko Takada; Hiroshi Kondoh; Mitsuhiro Yanagida
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2016, Peer-reviewed
      • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
        William H. Goodson; Leroy Lowe; David O. Carpenter; Michael Gilbertson; Abdul Manaf Ali; Adela Lopez de Cerain Salsamendi; Ahmed Lasfar; Amancio Carnero; Amaya Azqueta; Amedeo Amedei; Amelia K. Charles; Andrew R. Collins; Andrew Ward; Anna C. Salzberg; Annamaria Colacci; Ann-Karin Olsen; Arthur Berg; Barry J. Barclay; Binhua P. Zhou; Carmen Blanco-Aparicio; Carolyn J. Baglole; Chenfang Dong; Chiara Mondello; Chia-Wen Hsu; Christian C. Naus; Clement Yedjou; Colleen S. Curran; Dale W. Laird; Daniel C. Koch; Danielle J. Carlin; Dean W. Felsher; Debasish Roy; Dustin G. Brown; Edward Ratovitski; Elizabeth P. Ryan; Emanuela Corsini; Emilio Rojas; Eun-Yi Moon; Ezio Laconi; Fabio Marongiu; Fahd Al-Mulla; Ferdinando Chiaradonna; Firouz Darroudi; Francis L. Martin; Frederik J. Van Schooten; Gary S. Goldberg; Gerard Wagemaker; Gladys Nangami; Gloria M. Calaf; Graeme Williams; Gregory T. Wolf; Gudrun Koppen; Gunnar Brunborg; H. Kim Lyerly; Harini Krishnan; Hasiah Ab Hamid; Hemad Yasaei; Hideko Sone; Hiroshi Kondoh; Hosni K. Salem; Hsue-Yin Hsu; Hyun Ho Park; Igor Koturbash; Isabelle R. Miousse; A. Ivana Scovassi; James E. Klaunig; Jan Vondracek; Jayadev Raju; Jesse Roman; John Pierce Wise; Jonathan R. Whitfield; Jordan Woodrick; Joseph A. Christopher; Josiah Ochieng; Juan Fernando Martinez-Leal; Judith Weisz; Julia Kravchenko; Jun Sun; Kalan R. Prudhomme; Kannan Badri Narayanan; Karine A. Cohen-Solal; Kim Moorwood; Laetitia Gonzalez; Laura Soucek; Le Jian; Leandro S. D'Abronzo; Liang-Tzung Lin; Lin Li; Linda Gulliver; Lisa J. McCawley; Lorenzo Memeo; Louis Vermeulen; Luc Leyns; Luoping Zhang; Mahara Valverde; Mahin Khatami; Maria Fiammetta Romano; Marion Chapellier; Marc A. Williams; Mark Wade; Masoud H. Manjili; Matilde Lleonart; Menghang Xia; Michael J. Gonzalez; Michalis V. Karamouzis; Micheline Kirsch-Volders; Monica Vaccari; Nancy B. Kuemmerle; Neetu Singh; Nichola Cruickshanks; Nicole Kleinstreuer; Nik van Larebeke; Nuzhat Ahmed; Olugbemiga Ogunkua; P. K. Krishnakumar; Pankaj Vadgama; Paola A. Marignani; Paramita M. Ghosh; Patricia Ostrosky-Wegman; Patricia Thompson; Paul Dent; Petr Heneberg; Philippa Darbre; Po Sing Leung; Pratima Nangia-Makker; Qiang (Shawn) Cheng; R. Brooks Robey; Rabeah Al-Temaimi; Rabindra Roy; Rafaela Andrade-Vieira; Ranjeet K. Sinha; Rekha Mehta; Renza Vento; Riccardo Di Fiore; Richard Ponce-Cusi; Rita Dornetshuber-Fleiss; Rita Nahta; Robert C. Castellino; Roberta Palorini; Roslida Abd Hamid; Sabine A. S. Langie; Sakina Eltom; Samira A. Brooks; Sandra Ryeom; Sandra S. Wise; Sarah N. Bay; Shelley A. Harris; Silvana Papagerakis; Simona Romano; Sofia Pavanello; Staffan Eriksson; Stefano Forte; Stephanie C. Casey; Sudjit Luanpitpong; Tae-Jin Lee; Takemi Otsuki; Tao Chen; Thierry Massfelder; Thomas Sanderson; Tiziana Guarnieri; Tove Hultman; Valerian Dormoy; Valerie Odero-Marah; Venkata Sabbisetti; Veronique Maguer-Satta; W. Kimryn Rathmell; Wilhelm Engstrom; William K. Decker; William H. Bisson; Yon Rojanasakul; Yunus Luqmani; Zhenbang Chen; Zhiwei Hu
        CARCINOGENESIS, Jun. 2015, Peer-reviewed
      • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
        William H. Goodson; Leroy Lowe; David O. Carpenter; Michael Gilbertson; Abdul Manaf Ali; Adela Lopez de Cerain Salsamendi; Ahmed Lasfar; Amancio Carnero; Amaya Azqueta; Amedeo Amedei; Amelia K. Charles; Andrew R. Collins; Andrew Ward; Anna C. Salzberg; Annamaria Colacci; Ann-Karin Olsen; Arthur Berg; Barry J. Barclay; Binhua P. Zhou; Carmen Blanco-Aparicio; Carolyn J. Baglole; Chenfang Dong; Chiara Mondello; Chia-Wen Hsu; Christian C. Naus; Clement Yedjou; Colleen S. Curran; Dale W. Laird; Daniel C. Koch; Danielle J. Carlin; Dean W. Felsher; Debasish Roy; Dustin G. Brown; Edward Ratovitski; Elizabeth P. Ryan; Emanuela Corsini; Emilio Rojas; Eun-Yi Moon; Ezio Laconi; Fabio Marongiu; Fahd Al-Mulla; Ferdinando Chiaradonna; Firouz Darroudi; Francis L. Martin; Frederik J. Van Schooten; Gary S. Goldberg; Gerard Wagemaker; Gladys Nangami; Gloria M. Calaf; Graeme Williams; Gregory T. Wolf; Gudrun Koppen; Gunnar Brunborg; H. Kim Lyerly; Harini Krishnan; Hasiah Ab Hamid; Hemad Yasaei; Hideko Sone; Hiroshi Kondoh; Hosni K. Salem; Hsue-Yin Hsu; Hyun Ho Park; Igor Koturbash; Isabelle R. Miousse; A. Ivana Scovassi; James E. Klaunig; Jan Vondracek; Jayadev Raju; Jesse Roman; John Pierce Wise; Jonathan R. Whitfield; Jordan Woodrick; Joseph A. Christopher; Josiah Ochieng; Juan Fernando Martinez-Leal; Judith Weisz; Julia Kravchenko; Jun Sun; Kalan R. Prudhomme; Kannan Badri Narayanan; Karine A. Cohen-Solal; Kim Moorwood; Laetitia Gonzalez; Laura Soucek; Le Jian; Leandro S. D'Abronzo; Liang-Tzung Lin; Lin Li; Linda Gulliver; Lisa J. McCawley; Lorenzo Memeo; Louis Vermeulen; Luc Leyns; Luoping Zhang; Mahara Valverde; Mahin Khatami; Maria Fiammetta Romano; Marion Chapellier; Marc A. Williams; Mark Wade; Masoud H. Manjili; Matilde Lleonart; Menghang Xia; Michael J. Gonzalez; Michalis V. Karamouzis; Micheline Kirsch-Volders; Monica Vaccari; Nancy B. Kuemmerle; Neetu Singh; Nichola Cruickshanks; Nicole Kleinstreuer; Nik van Larebeke; Nuzhat Ahmed; Olugbemiga Ogunkua; P. K. Krishnakumar; Pankaj Vadgama; Paola A. Marignani; Paramita M. Ghosh; Patricia Ostrosky-Wegman; Patricia Thompson; Paul Dent; Petr Heneberg; Philippa Darbre; Po Sing Leung; Pratima Nangia-Makker; Qiang (Shawn) Cheng; R. Brooks Robey; Rabeah Al-Temaimi; Rabindra Roy; Rafaela Andrade-Vieira; Ranjeet K. Sinha; Rekha Mehta; Renza Vento; Riccardo Di Fiore; Richard Ponce-Cusi; Rita Dornetshuber-Fleiss; Rita Nahta; Robert C. Castellino; Roberta Palorini; Roslida Abd Hamid; Sabine A. S. Langie; Sakina Eltom; Samira A. Brooks; Sandra Ryeom; Sandra S. Wise; Sarah N. Bay; Shelley A. Harris; Silvana Papagerakis; Simona Romano; Sofia Pavanello; Staffan Eriksson; Stefano Forte; Stephanie C. Casey; Sudjit Luanpitpong; Tae-Jin Lee; Takemi Otsuki; Tao Chen; Thierry Massfelder; Thomas Sanderson; Tiziana Guarnieri; Tove Hultman; Valerian Dormoy; Valerie Odero-Marah; Venkata Sabbisetti; Veronique Maguer-Satta; W. Kimryn Rathmell; Wilhelm Engstrom; William K. Decker; William H. Bisson; Yon Rojanasakul; Yunus Luqmani; Zhenbang Chen; Zhiwei Hu
        CARCINOGENESIS, Jun. 2015, Peer-reviewed
      • Dysregulated glycolysis as an oncogenic event
        Takumi Mikawa; Matilde E. LLeonart; Akifumi Takaori-Kondo; Nobuya Inagaki; Masayuki Yokode; Hiroshi Kondoh
        CELLULAR AND MOLECULAR LIFE SCIENCES, May 2015, Peer-reviewed
      • Hepatocyte Nuclear Factor-1 beta (HNF-1 beta) Promotes Glucose Uptake and Glycolytic Activity in Ovarian Clear Cell Carcinoma
        Takako Okamoto; Masaki Mandai; Noriomi Matsumura; Ken Yamaguchi; Hiroshi Kondoh; Yasuaki Amano; Tsukasa Baba; Junzo Hamanishi; Kaoru Abiko; Kenzo Kosaka; Susan K. Murphy; Seiichi Mori; Ikuo Konishi
        MOLECULAR CARCINOGENESIS, Jan. 2015, Peer-reviewed
      • Metabolism of Skin-Absorbed Resveratrol into Its Glucuronized Form in Mouse Skin
        Itsuo Murakami; Romanas Chaleckis; Tomas Pluskal; Ken Ito; Kousuke Hori; Masahiro Ebe; Mitsuhiro Yanagida; Hiroshi Kondoh
        PLOS ONE, Dec. 2014, Peer-reviewed
      • Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity
        Takeshi Tsusaka; Tingting Guo; Teiti Yagura; Toshiaki Inoue; Masayuki Yokode; Nobuya Inagaki; Hiroshi Kondoh
        GENES TO CELLS, Oct. 2014, Peer-reviewed
      • Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
        Takumi Mikawa; Takeshi Maruyama; Koji Okamoto; Hitoshi Nakagama; Matilde E. Lleonart; Takeshi Tsusaka; Kousuke Hori; Itsuo Murakami; Taisuke Izumi; Akifumi Takaori-Kondo; Masayuki Yokode; Gordon Peters; David Beach; Hiroshi Kondoh
        JOURNAL OF CELL BIOLOGY, Mar. 2014, Peer-reviewed
      • Posttranscriptional Regulation of Glycolytic enzyme Phosphoglycerate Mutase.
        Takumi Mikawa; Koji Okamoto; Matilde E LLeonart; Akifumi Takaori-Kondo; Masayuki Yokode; Nobuya Inagaki; Hiroshi Kondoh
        Science Proceedings, 2014, Peer-reviewed
      • Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites
        Romanas Chaleckis; Masahiro Ebe; Tomas Pluskal; Itsuo Murakami; Hiroshi Kondoh; Mitsuhiro Yanagida
        MOLECULAR BIOSYSTEMS, 2014, Peer-reviewed
      • RING-mutant Mdm2-M459I Confers Anti-apoptotic Effect in Primary Cells
        Takumi Mikawa; Matilde E LLeonart; Akifumi Takaori-Kondo; Masayuki Yokode; Hiroshi Kondoh
        Journal of Cytology & Histology, 2014, Peer-reviewed
      • Metabolomic analysis of human blood, plasma and red bloods cells in comparision with eukaryotic microbe
        ROMANAS Chaleckis; TOMAS Pluskal; HAYASHI Takeshi; KONDOH Hiroshi; YANAGIDA Mitsuhiro
        Rinsho Ketsueki, 30 Oct. 2013
      • miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-alpha, CCNJ, and MEGF9
        Andrea Feliciano; Josep Castellvi; Ana Artero-Castro; Jose A. Leal; Cleofe Romagosa; Javier Hernandez-Losa; Vicente Peg; Angels Fabra; Francisco Vidal; Hiroshi Kondoh; Santiago Ramon y Cajal; Matilde E. LLeonart
        PLOS ONE, Oct. 2013, Peer-reviewed
      • Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice
        Junji Okuda; Shinnichiro Niizuma; Tetsuo Shioi; Takao Kato; Yasutaka Inuzuka; Tsuneaki Kawashima; Yodo Tamaki; Akira Kawamoto; Yohei Tanada; Yoshitaka Iwanaga; Michiko Narazaki; Tetsuya Matsuda; Souichi Adachi; Tomoyoshi Soga; Genzou Takemura; Hiroshi Kondoh; Toru Kita; Takeshi Kimura
        PLOS ONE, Aug. 2013, Peer-reviewed
      • Role of senescence induction in cancer therapy
        Hiroshi Kondoh; Takumi Mikawa; Matilde E. Lleonart
        Tumor Dormancy, Quiescence, and Senescence: Aging, Cancer, and Noncancer Pathologies, 01 Jan. 2013, Peer-reviewed
      • Oxidative stress and cancer: An overview
        Venus Sosa; Teresa Moline; Rosa Somoza; Rosanna Paciucci; Hiroshi Kondoh; Matilde E. LLeonart
        AGEING RESEARCH REVIEWS, Jan. 2013, Peer-reviewed
      • Impact of COPD Exacerbations on Osteoporosis Assessed by Chest CT Scan
        Hirofumi Kiyokawa; Shigeo Muro; Tsuyoshi Oguma; Susumu Sato; Naoya Tanabe; Tamaki Takahashi; Megumi Kudo; Daisuke Kinose; Hiroshi Kondoh; Takeshi Kubo; Yuma Hoshino; Emiko Ogawa; Toyohiro Hirai; Michiaki Mishima
        COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Jun. 2012, Peer-reviewed
      • Identifying cognitive dysfunction using the nurses' rapidly clinical judgment in elderly inpatients
        Mihoko Ogita; Hajime Takechi; Atsuko Kokuryu; Hiroshi Kondoh; Yoshiyuki Hamakawa; Hidenori Arai
        Journal of Clinical Gerontology and Geriatrics, Mar. 2012, Peer-reviewed
      • Induced Pluripotent Stem Cell Technology for the Study of Neurodegenerative Diseases.
        Kitaoka S; Kondoh H; Inoue H
        Induced Stem Cells, chapter Ⅴ, Nova Science Publishers Inc, New York, p129-142., 2012, Peer-reviewed
      • Induced pluripotent stem cell technology for the study of neurodegenerative diseases
        S. Kitaoka; H. Kondoh; H. Inoue
        Stem Cell Research Journal, 2011, Peer-reviewed
      • MicroRNAs regulate key effector pathways of senescence
        Andrea Feliciano; Beatriz Sánchez-Sendra; Hiroshi Kondoh; Matilde E. Lleonart
        Journal of Aging Research, 2011, Peer-reviewed
      • HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication
        Taisuke Izumi; Katsuhiro Io; Masashi Matsui; Kotaro Shirakawa; Masanobu Shinohara; Yuya Nagai; Masahiro Kawahara; Masayuki Kobayashi; Hiroshi Kondoh; Naoko Misawa; Yoshio Koyanagi; Takashi Uchiyama; Akifumi Takaori-Kondo
        Proceedings of the National Academy of Sciences of the United States of America, 30 Nov. 2010, Peer-reviewed
      • Regulational Role of Mitochondria on Ageing and Senescence.
        Hiroshi Kondoh; Haruhisa Inoue; Akifumi Takaori-Kondo; Takumi Mikawa; Manabu Minami
        Horizons in DNA Research, Volume 1 by Nova, New York, 2010 p235-240, 2010, Peer-reviewed
      • Rplp1 bypasses replicative senescence and contributes to transformation
        A. Artero-Castro; H. Kondoh; P. J. Fernandez-Marcos; M. Serrano; S. Ramon y Cajal; M. E. LLeonart
        EXPERIMENTAL CELL RESEARCH, May 2009, Peer-reviewed
      • Cold-Inducible RNA-Binding Protein Bypasses Replicative Senescence in Primary Cells through Extracellular Signal-Regulated Kinase 1 and 2 Activation
        Ana Artero-Castro; Francisco B. Callejas; Josep Castellvi; Hiroshi Kondoh; Amancio Carnero; Pablo J. Fernandez-Marcos; Manuel Serrano; Santiago Ramon y Cajal; Matilde E. Lleonart
        MOLECULAR AND CELLULAR BIOLOGY, Apr. 2009, Peer-reviewed
      • The role of glycolysis in cellular immortalization
        Hiroshi Kondoh
        Cellular Respiration and Carcinogenesis, 2009, Peer-reviewed
      • Bypassing senescence; a booster for cell proliferation.
        Hiroshi Kondoh; Takeshi Maruyama
        Handbook of Cell proliferation. Published by Nova, New York, 2009 363-70, 2009, Peer-reviewed
      • The anti-ageing effect of enhanced glycolysis; another role of the Warburg effect.
        Hiroshi Kondoh; Takeshi Maruyama
        Glycolysis:Regulation, Processes and Diseases. Published by Nova, New York, 2009 p171-178, 2009, Peer-reviewed
      • Glycolysis during ageing
        H. Kondoh
        Japanese Journal of Geriatrics, 2009, Peer-reviewed
      • Senescence induction; a possible cancer therapy
        Matilde E. LLeonart; Ana Artero-Castro; Hiroshi Kondoh
        MOLECULAR CANCER, Jan. 2009, Peer-reviewed
      • MDM2 is a novel E3 ligase for HIV-1 Vif
        Taisuke Izumi; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hiroaki Higashitsuji; Katsuhiko Itoh; Katsuhiro Io; Masashi Matsui; Kazuhiro Iwai; Hiroshi Kondoh; Toshihiro Sato; Mitsunori Tomonaga; Satoru Ikeda; Hirofumi Akari; Yoshio Koyanagi; Jun Fujita; Takashi Uchiyama
        RETROVIROLOGY, Jan. 2009, Peer-reviewed
      • Cellular life span and the Warburg effect
        Hiroshi Kondoh
        EXPERIMENTAL CELL RESEARCH, May 2008, Peer-reviewed
      • A common metabolic profile shared between murine ES cells and primary cells bypassing senescence.
        Hiroshi Kondoh; Matilde E. Lleonart; Yasuhiro Nakashima; Takeshi Maruyama; Masayuki Yokode; Makoto Tanaka; David Bernard; Jesus Gil
        Medical Hypotheses and Research 2008.4.29-36, 2008, Peer-reviewed
      • Senescence as a target of cancer therapy.
        Hiroshi Kondoh; Takeshi Maruyama; Matilde E. Lleonart
        Open Pathology 2008 2,57-62, 2008, Peer-reviewed
      • A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
        Hiroshi Kondoh; Matilde E. Lleonart; Yasuhiro Nakashima; Masayuki Yokode; Makoto Tanaka; David Bernard; Jesus Gil; David Beach
        ANTIOXIDANTS & REDOX SIGNALING, Mar. 2007, Peer-reviewed
      • Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization
        H. Kondoh; M. E. Lleonart; D. Bernard; J. Gil
        HISTOLOGY AND HISTOPATHOLOGY, Jan. 2007, Peer-reviewed
      • Senescence-related genes in human tumors: significant down regulation of the RPS6KA6 and KIAA0828 genes in colon and KIAA0828 and Tip60 in lung carcinomas.
        Lleonart ME; Vidal F; Gallardo D; Diaz M; Hernandez J; Rojo F; Cuatrecasas M; Lopez L; Hiroshi Kondoh; Sanchez Prieto R; Ramony Cajal S
        Oncology Reports 2006, 16, 603-8, 2006, Peer-reviewed
      • Protection from the senescence effects of oxidative stress in ES cells.
        Hiroshi Kondoh; Jesus Gil
        Stem Cell Therapy. Published by Nova Science , New York 2006 175-190, 2006, Peer-reviewed
      • Glycolytic enzymes can modulate cellular life span
        H Kondoh; ME Lleonart; J Gil; J Wang; P Degan; G Peters; D Martinez; A Carnero; D Beach
        CANCER RESEARCH, Jan. 2005, Peer-reviewed
      • Glycolysis and cellular immortalization
        Hiroshi Kondoh; Matilde E. Lleonart; Jesus Gil; David Beach; Gordon Peters
        Drug Discovery Today: Disease Mechanisms, 2005, Peer-reviewed
      • Mis3 with a conserved RNA binding motif is essential for ribosome biogenesis and implicated in the start of cell growth and S phase checkpoint
        H Kondoh; T Yuasa; M Yanagida
        GENES TO CELLS, Jul. 2000, Peer-reviewed
      • The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis
        K Kinoshita; T Nemoto; K Nabeshima; H Kondoh; H Niwa; M Yanagida
        GENES TO CELLS, Jan. 1996, Peer-reviewed

      Misc.

      • Senescence-inducing stress and glycolytic enzyme, PGAM
        Hiroshi Kondoh; Takumi Mikawa; Nobuya Inagaki
        Seikagaku, 2016
      • 経腸栄養下DRV投与が有効であった食道瘻を伴う粟粒結核合併AIDSの一例
        水野菜穂子; 小林正行; 原島伸一; 近藤祥司; 尾崎淳子; 辻秀美; 幣憲一郎; 稲垣暢也; 高折晃史
        日本エイズ学会誌, 20 Nov. 2015
      • Disruptive chemicals, senescence and immortality
        Amancio Carnero; Carmen Blanco-Aparicio; Hiroshi Kondoh; Matilde E. Lleonart; Juan Fernando Martinez-Leal; Chiara Mondello; A. Ivana Scovassi; William H. Bisson; Amedeo Amedei; Rabindra Roy; Jordan Woodrick; Annamaria Colacci; Monica Vaccari; Jayadev Raju; Fahd Al-Mulla; Rabeah Al-Temaimi; Hosni K. Salem; Lorenzo Memeo; Stefano Forte; Neetu Singh; Roslida A. Hamid; Elizabeth P. Ryan; Dustin G. Brown; John Pierce Wise; Sandra S. Wise; Hemad Yasaei
        CARCINOGENESIS, Jun. 2015
      • ES細胞増殖に必須な代謝特性としての解糖系代謝亢進
        KONDO HIROSHI; NAKASHIMA YASUHIRO; MARUYAMA TAKESHI; TANAKA MAKOTO; YOKODE MASAYUKI
        再生医療, 01 May 2008

      Presentations

      • 老化・加齢性疾患に関連するメタボライトや解糖系代謝機構の解明
        近藤祥司
        先端モデル動物⽀援プラットフォーム成果発表会, 02 Feb. 2021
      • 老化や加齢性疾患関連メタボライトと解糖系代謝機構の同定
        近藤祥司
        日本分子生物学会, 03 Dec. 2020
      • 網羅的全血メタボローム解析による新規フレイルマーカーの発見
        近藤祥司
        日本老年医学会近畿地方会, 21 Nov. 2020
      • 簡易版京都フレイルスクリーニングスケール「KFS」の有用性
        近藤祥司
        日本老年医学会近畿地方会, 21 Nov. 2020
      • PGAM の「非酵素機能」によるワールブルグ解糖系新規制御機構
        近藤祥司
        日本抗加齢医学会, 25 Sep. 2020
      • 網羅的全血メタボローム解析による新規フレイルマーカーの発見
        近藤祥司
        日本老年医学会, 05 Aug. 2020
      • 網羅的全血メタボロームによる老化研究
        近藤祥司
        第43回日本基礎老化学会大会, 10 May 2020
      • 網羅的全血メタボローム解析による新規フレイルマーカーの発見
        近藤祥司
        先端動物モデル成果発表会, 31 Jan. 2020
      • 解糖系酵素PGAMによる新規解糖系制御機構
        三河拓己; 近藤祥司
        第30回日本老年医学会近畿地方会, 16 Nov. 2019
      • Identification of the metabolites and glycolytic regulation involved in ageing and its relevant diseases.
        近藤祥司
        France-Japan workshop, 06 Sep. 2019, Invited
      • ヒト絶食による代謝シフトの網羅的解析
        近藤 祥司
        日本老年医学会, 08 Jun. 2019
      • 老化の多様性を規定する解糖系代謝恒常性の維持・変容・破綻による病態の解明
        近藤 祥司
        第61回日本老年医学会, 06 Jun. 2019
      • ワールブルグ解糖系代謝の新規分子制御メカニズムの解明
        近藤 祥司
        先端動物モデル成果発表会, 31 Jan. 2019
      • ヒト絶食による代謝シフトの網羅的解析
        近藤 祥司
        日本老年医学会近畿地方会, 17 Nov. 2018
      • 老化・癌化におけるメタボライトと解糖系代謝研究
        近藤 祥司
        第60回日本老年医学会, 14 Jun. 2018
      • 解糖系代謝新規制御機構の解明
        近藤 祥司
        先端モデル動物支援プラットフォーム成果発表会, 25 Jan. 2018
      • がんと代謝研究の最前線
        近藤 祥司
        抗加齢医学会, 02 Jun. 2017
      • 老化に伴う多角的治療戦略
        近藤 祥司
        第60回日本心身医学会近畿地方会, 02 Mar. 2017
      • ストレス老化シグナルと解糖系代謝
        近藤 祥司
        第68回日本細胞生物学会, 16 Jun. 2016
      • 老化の多様性を規定する代謝・液性因子
        近藤 祥司
        第58回日本老年医学会, 09 Jun. 2016
      • ストレス老化シグナルに拮抗するワールブルグ解糖系転写後制御
        近藤 祥司
        第36回日本炎症・再生医学会, 23 Jul. 2015
      • 老化シグナルによる解糖系酵素PGAMの転写後制御機構 Posttranscriptional regulation of PGAM by senescence-inducing signal
        近藤 祥司
        基礎老化学会, 13 Jun. 2015
      • ストレス老化シグナルによる解糖系ユビキチン化制御とその病態意義
        近藤 祥司
        第57回日本老年医学会学術集会, 13 Jun. 2015
      • Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
        近藤 祥司
        The Controlling Cancer Summit London, 12 May 2015
      • 老化はなぜ進むのか
        近藤 祥司
        第29回日本医学会総会, 05 Apr. 2015, Invited
      • ストレス老化シグナルによる解糖系酵素PGAMのユビキチン化制御
        近藤 祥司
        第32回染色体ワークショップ, 16 Dec. 2014
      • ストレス老化シグナルによる解糖系代謝シフトの誘導する生体防御バリアー機構
        近藤 祥司
        分子生物学会, 26 Nov. 2014
      • ストレス老化シグナルによる解糖系ユビキチン化制御とその病態意義;
        近藤 祥司
        第5回癌・炎症と抗酸化研究 CIA, 15 Nov. 2014
      • ストレス老化シグナルによる解糖系ユビキチン化制御とその生体防御機構
        近藤 祥司
        日本皮膚学会西部支部, 08 Nov. 2014
      • 細胞老化誘導性DNAダメージによる解糖系ワールブルグ効果の制御機構
        近藤 祥司
        癌学会コアシンポジウム, 27 Sep. 2014
      • Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
        近藤 祥司
        日本基礎老化学会, 27 Jun. 2014
      • 老化から癌化への転換に重要な解糖系ユビキチン制御機構
        近藤 祥司
        日本・多国間臨床試験機構(JMTO), 26 Jun. 2014
      • ストレス老化シグナルによる解糖系代謝シフトの誘導する生体防御バリアー機構
        近藤 祥司
        第14回日本抗加齢医学会プレシンポジウム, 06 Jun. 2014
      • ストレス老化シグナルによる解糖系調節の誘導する癌化バリアー形成
        近藤 祥司
        第一回癌と代謝研究会, 30 Oct. 2013
      • ストレス老化シグナルによる解糖系調節の誘導する癌化バリアー
        近藤 祥司
        がんと代謝シンポジウム2013, 17 Jan. 2013
      • ストレス老化シグナルによる解糖系代謝調節の誘導する生体防御バリアー形成
        近藤 祥司
        第29回臨床フリーラジカル会議, 08 Dec. 2012
      • 老化はなぜ進むのか?遺伝子から見た老化と老化から診る生活習慣病
        近藤 祥司
        第25回日本冠疾患学会学術集会, 17 Dec. 2011
      • Cellular lifespan and the Warburg effect
        近藤 祥司
        5th International workshop on regulations in cell cycle & arrest, 25 Oct. 2011
      • 老化生物学 老いと寿命のメカニズム
        近藤 祥司, Supervisor, 全390ページ
        MEDSI, Aug. 2015, Not refereed
      • シリーズ進化生物学の新潮流;老化という生存戦略;進化におけるトレードオフ
        近藤 祥司, Single work, 全222ページ
        日本評論社, Jul. 2015, Not refereed
      • 老化はなぜ進むのか
        近藤祥司
        講談社ブルーバックス, 20 Dec. 2009, Not refereed

      Awards

      • Jun. 2014
        日本基礎老化学会, 第37回日本基礎老化学会大会若手奨励賞

      External funds: Kakenhi

      • 超高齢社会医療再構築を支える老化関連メタボライト探索萌芽研究
        Grant-in-Aid for Challenging Research (Exploratory)
        Studies on the Super-Aging Society
        Kyoto University
        近藤 祥司
        From 30 Jul. 2020, To 31 Mar. 2022, Granted
        メタボライト;老化
      • Innovative search of well-ageing related metabolites
        Grant-in-Aid for Challenging Research (Exploratory)
        Studies on the Super-Aging Society
        Kyoto University
        Hiroshi Kondoh
        From 29 Jun. 2018, To 31 Mar. 2020, Project Closed
        老化;メタボライト
      • Investigation for the metabolic basis of ageing diversity
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Hiroshi Kondoh
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        老化;解糖系代謝;多様性;代謝
      • Investigation for metabolic features in divergency of ageing
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Hirohsi Kondoh
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        老化;メタボライト
      • The analysis of conversion mechanism from ageing to tumorigenesis by the metabolic-remodeling of glycolysis.
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Takumi Mikawa
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        解糖系代謝;癌;PGAM;解糖系酵素;発がん;DNA損傷修復
      • Investigation for metabolic features in divergency of ageing
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Hirohsi Kondoh
        From 18 Jul. 2014, To 31 Mar. 2017, Project Closed
        老化;代謝
      • Metabolomic analysis for improvement of healthy lifespan
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Kondoh Hiroshi
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        老化
      • Senescence-inducing stress modulates glycolysis and the Warburg effect
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Hiroshi KONDOH
        From 01 Apr. 2011, To 31 Mar. 2014, Project Closed
        老化;老年医学;解糖系代謝;癌化;ストレス老化;発癌
      • Role of protein homeostasis in cardiac aging
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Tetsuo SHIOI
        From 01 Apr. 2009, To 31 Mar. 2012, Project Closed
        分子心臓病態学;心不全;エネルギー代謝;ミトコンドリア;SIRT1;代謝;老化;メタボローム;ジクロロアセテート;ラパマイシン
      • A study for an essential metabolic shift in glycolytic pathway observed during the transition from cellular senescence to carcinogenesis
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Hiroshi KONDOH
        From 01 Apr. 2008, To 31 Mar. 2011, Project Closed
        細胞老化;癌化;解糖系代謝

      External funds: others

      • 癌・疾病における細胞・個体老化 (平成28年度分)
        二国間交流事業共同研究・セミナー
        From 01 Apr. 2016, To 31 Mar. 2017
        近藤 祥司
      list
        Last Updated :2022/09/09

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Clinical Overview of Medicine F
          3228, Fall, Faculty of Medicine, 1
        • From Apr. 2014, To Mar. 2015
          Gerontology, Geriatrics, and Aging Science
          Spring, 医学研究科

        Part-time lecturer

        • 大分大学, 医学部
        • 神戸学院大学
        list
          Last Updated :2022/09/09

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2023
            病院協議会 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
             
          • From 01 Apr. 2022, To 31 Mar. 2023
            地域連携推進実務WG 委員長
          • From 01 Apr. 2022, To 31 Mar. 2023
            児童虐待対応専門部会 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            広報委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2014
            動物実験施設運営委員会
          • From 01 Sep. 2010, To 31 Mar. 2014
            外来医長・看護師長会議 委員
          • From 01 Apr. 2011
            病院運営連絡委員会 委員

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