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Shiromoto, Yusuke
Graduate School of Medicine, Medicine Program-Specific Assistant Professor
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Last Updated :2025/04/23
Basic Information
Academic Degree
Research History
- From Apr. 2021, To PresentKyoto University, 医学研究科
- From Oct. 2019, To Mar. 2021The Wistar Institute, Associate Staff Scientist
- From Oct. 2014, To Oct. 2019The Wistar Institute, Postdoctral fellow
- From Apr. 2017, To Mar. 2019The Wistar Institute, JSPS 海外特別研究員
- From Apr. 2014, To Oct. 2014大阪大学大学院医学系研究科, 特任研究員
ID,URL
J-Global ID
Researcher number
40912259
researchmap URL
list
Last Updated :2025/04/23
Research
Research Areas
Papers
- Intracytoplasmic sperm injection induces transgenerational abnormalities in miceMito Kanatsu-Shinohara; Yusuke Shiromoto; Narumi Ogonuki; Kimiko Inoue; Satoko Hattori; Kento Miura; Naomi Watanabe; Ayumi Hasegawa; Keiji Mochida; Takuya Yamamoto; Tsuyoshi Miyakawa; Atsuo Ogura; Takashi ShinoharaJournal of Clinical Investigation, 15 Nov. 2023, Lead author
- Allogeneic offspring produced by induction of PD-L1 in spermatogonial stem cells via self-renewal stimulationTakashi Shinohara; Takuya Yamamoto; Hiroko Morimoto; Yusuke Shiromoto; Mito Kanatsu-ShinoharaStem Cell Reports, Apr. 2023
- ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levelsXue Hao; Yusuke Shiromoto; Masayuki Sakurai; Martina Towers; Qiang Zhang; Shuai Wu; Aaron Havas; Lu Wang; Shelley Berger; Peter D. Adams; Bin Tian; Kazuko Nishikura; Andrew V. Kossenkov; Pingyu Liu; Rugang ZhangNature Cell Biology, 18 Jul. 2022
- Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids.Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Hiroko Morimoto; Yusuke Shiromoto; Atsuo Ogura; Takashi ShinoharaStem cell reports, 08 Mar. 2022, Peer-reviewed
- ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.Yusuke Shiromoto; Masayuki Sakurai; Moeko Minakuchi; Kentaro Ariyoshi; Kazuko NishikuraNature communications, 12 Mar. 2021
- Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets.Yusuke Shiromoto; Masayuki Sakurai; Helen Qu; Andrew V Kossenkov; Kazuko NishikuraRNA (New York, N.Y.), Dec. 2020
- GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice†.Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Ippei Nagamori; Shinichiro Chuma; Tatsuhiko Arakawa; Toru Nishimura; Hidetoshi Hasuwa; Taro Tachibana; Masahito Ikawa; Toru NakanoBiology of reproduction, 01 Jul. 2019
- Mouse GTSF1 is an essential factor for secondary piRNA biogenesis.Takuji Yoshimura; Toshiaki Watanabe; Satomi Kuramochi-Miyagawa; Noriaki Takemoto; Yusuke Shiromoto; Akihiko Kudo; Masami Kanai-Azuma; Fumi Tashiro; Satsuki Miyazaki; Ami Katanaya; Shinichiro Chuma; Jun-Ichi MiyazakiEMBO reports, Apr. 2018
- ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay.Masayuki Sakurai; Yusuke Shiromoto; Hiromitsu Ota; Chunzi Song; Andrew V Kossenkov; Jayamanna Wickramasinghe; Louise C Showe; Emmanuel Skordalakes; Hsin-Yao Tang; David W Speicher; Kazuko NishikuraNature structural & molecular biology, Jun. 2017
- Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases.Chunzi Song; Masayuki Sakurai; Yusuke Shiromoto; Kazuko NishikuraGenes, 17 Dec. 2016
- piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.Nicholas F Parrish; Kan Fujino; Yusuke Shiromoto; Yuka W Iwasaki; Hongseok Ha; Jinchuan Xing; Akiko Makino; Satomi Kuramochi-Miyagawa; Toru Nakano; Haruhiko Siomi; Tomoyuki Honda; Keizo TomonagaRNA (New York, N.Y.), Oct. 2015
- Comprehensive DNA Methylation Analysis of Retrotransposons in Male Germ Cells.Ippei Nagamori; Hisato Kobayashi; Yusuke Shiromoto; Toru Nishimura; Satomi Kuramochi-Miyagawa; Tomohiro Kono; Toru NakanoCell reports, 08 Sep. 2015
- Induction of DNA methylation by artificial piRNA production in male germ cells.Daisuke Itou; Yusuke Shiromoto; Shin-ya Yukiho; Chika Ishii; Toru Nishimura; Narumi Ogonuki; Atsuo Ogura; Hidetoshi Hasuwa; Yoshitaka Fujihara; Satomi Kuramochi-Miyagawa; Toru NakanoCurrent biology : CB, 30 Mar. 2015
- DNA methylation in mouse testes.Satomi Kuramochi-Miyagawa; Kanako Kita-Kojima; Yusuke Shiromoto; Daisuke Ito; Hirotaka Koshima; Toru NakanoMethods in molecular biology (Clifton, N.J.), 2014
- GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Akito Daiba; Shinichiro Chuma; Ami Katanaya; Akiko Katsumata; Ken Nishimura; Manami Ohtaka; Mahito Nakanishi; Toshinobu Nakamura; Koichi Yoshinaga; Noriko Asada; Shota Nakamura; Teruo Yasunaga; Kanako Kojima-Kita; Daisuke Itou; Tohru Kimura; Toru NakanoRNA (New York, N.Y.), Jun. 2013
- MVH in piRNA processing and gene silencing of retrotransposons.Satomi Kuramochi-Miyagawa; Toshiaki Watanabe; Kengo Gotoh; Kana Takamatsu; Shinichiro Chuma; Kanako Kojima-Kita; Yusuke Shiromoto; Noriko Asada; Atsushi Toyoda; Asao Fujiyama; Yasushi Totoki; Tatsuhiro Shibata; Tohru Kimura; Norio Nakatsuji; Toshiaki Noce; Hiroyuki Sasaki; Toru NakanoGenes & development, May 2010
Misc.
- TERTによるRNA合成とRNA編集との相互作用に関する検討毎田 佳子; 櫻井 雅之; 城本 悠助; 安川 麻美; Ghilotti Marco; 有吉 健太郎; 西倉 和子; 増富 健吉生命科学系学会合同年次大会, Dec. 2017
Presentations
- ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cellsShiromoto, Y; Sakurai, M; Minakuchi, M; Ariyoshi, K; Nishikura, KKEYSTONE SYMPOSIA, Oct. 2020
- ADAR1 controls apoptosis of stressed cells by inhibiting Staufen-mediated mRNA decaySakurai, M; Shiromoto, Y; Ota, H; Song, C; Kossenkov, A.V; Wickramasinghe, J; Showe, L.C; Skordalakes, E; Tao, H.Y; Speicher, D.W; Nishikura, KGordon Research Conference, Mar. 2017
Books and Other Publications
- RNA 編集酵素 ADAR1 はストレス下において mRNA 分解からの保護機構によりアポトーシスを抑制する櫻井雅之; 城本悠助; 西倉和子, Joint workライフサイエンス新着論文レビュー, 2017
External funds: Kakenhi
- The Mechanism of R-loop resolution in male germ cells and its effects on spermatogenesis and next generation.Grant-in-Aid for Research Activity Start-up0702:Biology at cellular to organismal levels, and related fieldsKyoto UniversityYusuke ShiromotoFrom 30 Aug. 2021, To 31 Mar. 2023, Project Closed精巣;精子幹細胞;R-loop;DNA損傷;精子形成
- piRNAを介した生殖細胞の脱分化・腫瘍化制御機構の解明Grant-in-Aid for Scientific Research (C)Basic Section 49030:Experimental pathology-relatedKyoto University城本 悠助From 01 Apr. 2022, To 31 Mar. 2025, Granted精子幹細胞;piRNA;生殖細胞腫瘍
- 精子幹細胞を用いたpiRNA経路の制御化合物の探索と精巣でのpiRNA経路の制御Fund for the Promotion of Joint International Research (Fostering Joint International Research)Basic Section 49030:Experimental pathology-relatedKyoto University城本 悠助From 01 Apr. 2023, To 31 Mar. 2024, Adopted
- Exploration of compounds regulating piRNA pathways using spermatogonial stem cells and regulation of piRNA pathways in the testis.Fund for the Promotion of Joint International Research (Fostering Joint International Research)Basic Section 49030:Experimental pathology-relatedKyoto University城本 悠助From 01 Apr. 2024, To 31 Mar. 2027, Granted精子幹細胞;piRNA;化合物スクリーニング
