Basic Information

Faculty

• Faculty of Medicine

Professional Memberships

• The Physiological Society of Japan
• The Japanese Pharmacological Society
• The Japan Society for Neuroscience
• Society for Neuoscience

Academic Degree

• 1994

  MD, PhD(Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, Graduate School of Medicine, Physiology, completed

Academic Resume (Undergraduate School/Majors)

• Kyoto University, Faculty of Medicine, Medicine, graduated

Research History

• From 2016, To Present

  Kyoto University Graduate School of Medicine, Professor
• From 2009, To 2017

  RIKEN Brain Science Institute, Team Leader
• From 2000, To 2009

  Massachusetts Institute of Technology, RIKEN-MIT Neuroscience Research Center, Assistant Professor
• From 1996, To 2000

  Cold Spring Harbor Laboratory, Postdoctral Fellow
• From 1994, To 1996

  Tokyo University, School of Medicine, JSPS postdoctral fellow

Profile

• Profile

  Yasunori Hayashi is a Japanese neuroscientist born in Aichi, grew up in Tokyo. He is leading his research group in Kyoto University Graduate School of Medicine. His main interest is the molecular mechanism of learning and memory.

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0002-7560-3004

• J-Global ID

  201101082088016907

• Researcher number

  90466037

• External link

  http://glutamate.med.kyoto-u.ac.jp/

Website(s) (URL(s))

• glutamate.med.kyoto-u.ac.jp/e/

researchmap URL

• https://researchmap.jp/2rikenbsi

Research

Research Topics, Overview of the research

• Research Topics

  Neuroscience

Research Interests

• Förster-resonance energy transfer
• two-photon microscopy
• glutamate receptor
• hippocampus
• synaptic plasticity
• hippocampal slice
• long-term potentiation
• calcium/calmodulin-dependent protein kinase (CaMKII)
• virus vector
• actin
• dendritic spine
• sleep
• learning and memory
• calcium
• cellular signal transduction
• cytoskeleton
• cofilin
• two-photon laser scanning microscope

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general

Papers

• Offline neuronal activity and synaptic plasticity during sleep and memory consolidation

  Akihiro Goto; Yasunori Hayashi

  Neuroscience Research, Dec. 2022

  
• CaMKII binds both substrates and activators at the active site.

  Can Özden; Roman Sloutsky; Tomohiro Mitsugi; Nicholas Santos; Emily Agnello; Christl Gaubitz; Joshua Foster; Emily Lapinskas; Edward A Esposito; Takeo Saneyoshi; Brian A Kelch; Scott C Garman; Yasunori Hayashi; Margaret M Stratton

  Cell reports, 12 Jul. 2022

  
• HOTARU: Automatic sorting system for large scale calcium imaging data

  Takashi Takekawa; Masanori Nomoto; Hirotaka Asai; Noriaki Ohkawa; Reiko Okubo-Suzuki; Khaled Ghandour; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Shin-ichi Muramatsu; Yasunori Hayashi; Kaoru Inokuchi; Tomoki Fukai

  bioRxiv, 07 Apr. 2022

  
• CaMKIIの新しいシナプス可塑性機構

  林 康紀; 細川 智永; 劉 品吾; 實吉 岳郎

  生化学, Apr. 2021

  
• Shared and unique properties of place cells in anterior cingulate cortex and hippocampus

  Ayaka Bota; Akihiro Goto; Suzune Tsukamoto; Alexander Schmidt; Fred Wolf; Alessandro Luchetti; Junichi Nakai; Hajime Hirase; Yasunori Hayashi

  30 Mar. 2021

  
• Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.

  Risa Takamura; Kotaro Mizuta; Yukiko Sekine; Tanvir Islam; Takashi Saito; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Toshio Ohshima; Takaomi C Saido; Yasunori Hayashi

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 16 Jun. 2021

  
• Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis.

  Elena Cid; Angel Marquez-Galera; Manuel Valero; Beatriz Gal; Daniel C Medeiros; Carmen M Navarron; Luis Ballesteros-Esteban; Rita Reig-Viader; Aixa V Morales; Ivan Fernandez-Lamo; Daniel Gomez-Dominguez; Masaaki Sato; Yasunori Hayashi; Àlex Bayés; Angel Barco; Jose P Lopez-Atalaya; Liset M de la Prida

  Cell reports, 08 Jun. 2021

  
• CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.

  Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; Daniel Choquet; Laurent Groc; Eric Hosy; Mingjie Zhang; Yasunori Hayashi

  Nature neuroscience, Jun. 2021

  
• Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines.

  Ria Fajarwati Kastian; Takunori Minegishi; Kentarou Baba; Takeo Saneyoshi; Hiroko Katsuno-Kambe; Singh Saranpal; Yasunori Hayashi; Naoyuki Inagaki

  Cell reports, 18 May 2021

  
• Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.

  Maria S Eriksen; Oleksii Nikolaienko; Erik I Hallin; Sverre Grødem; Helene J Bustad; Marte I Flydal; Ian Merski; Tomohisa Hosokawa; Daniela Lascu; Shreeram Akerkar; Jorge Cuéllar; James J Chambers; Rory O'Connell; Gopinath Muruganandam; Remy Loris; Christine Touma; Tambudzai Kanhema; Yasunori Hayashi; Margaret M Stratton; José M Valpuesta; Petri Kursula; Aurora Martinez; Clive R Bramham

  The FEBS journal, May 2021

  
• Regulation of synaptic nanodomain by liquid-liquid phase separation: A novel mechanism of synaptic plasticity.

  Pin-Wu Liu; Tomohisa Hosokawa; Yasunori Hayashi

  Current opinion in neurobiology, 19 Mar. 2021

  
• Multiple coordinated cellular dynamics mediate CA1 map plasticity.

  Kotaro Mizuta; Junichi Nakai; Yasunori Hayashi; Masaaki Sato

  Hippocampus, Mar. 2021

  
• Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System.

  Yasunori Hayashi; Lenzie K Ford; Luana Fioriti; Leeanne McGurk; Mingjie Zhang

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 03 Feb. 2021

  
• Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.

  Masaaki Sato; Kotaro Mizuta; Tanvir Islam; Masako Kawano; Yukiko Sekine; Takashi Takekawa; Daniel Gomez-Dominguez; Alexander Schmidt; Fred Wolf; Karam Kim; Hiroshi Yamakawa; Masamichi Ohkura; Min Goo Lee; Tomoki Fukai; Junichi Nakai; Yasunori Hayashi

  Cell reports, 07 Jul. 2020, Peer-reviewed

  
• Two Functionally Distinct Serotonergic Projections into Hippocampus.

  Alessandro Luchetti; Ayaka Bota; Adam Weitemier; Kotaro Mizuta; Masaaki Sato; Tanvir Islam; Thomas J McHugh; Ayumu Tashiro; Yasunori Hayashi

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 17 Jun. 2020, Peer-reviewed

  
• Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.

  Qixu Cai; Tomohisa Hosokawa; Menglong Zeng; Yasunori Hayashi; Mingjie Zhang

  Structure (London, England : 1993), 03 Mar. 2020, Peer-reviewed

  
• The role of CaMKII-Tiam1 complex on learning and memory.

  Hiroto Kojima; Morgane Rosendale; Yui Sugiyama; Mariko Hayashi; Yoko Horiguchi; Toru Yoshihara; Yuji Ikegaya; Takeo Saneyoshi; Yasunori Hayashi

  Neurobiology of learning and memory, Dec. 2019, Peer-reviewed

  
• Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP.

  Takeo Saneyoshi; Hitomi Matsuno; Akio Suzuki; Hideji Murakoshi; Nathan G Hedrick; Emily Agnello; Rory O'Connell; Margaret M Stratton; Ryohei Yasuda; Yasunori Hayashi

  Neuron, 19 Jun. 2019, Peer-reviewed

  
• Orchestrated ensemble activities constitute a hippocampal memory engram.

  Khaled Ghandour; Noriaki Ohkawa; Chi Chung Alan Fung; Hirotaka Asai; Yoshito Saitoh; Takashi Takekawa; Reiko Okubo-Suzuki; Shingo Soya; Hirofumi Nishizono; Mina Matsuo; Makoto Osanai; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Yasunori Hayashi; Takeshi Sakurai; Takashi Kitamura; Tomoki Fukai; Kaoru Inokuchi

  Nature communications, 14 Jun. 2019, Peer-reviewed

  
• Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex.

  Takuma Kobayashi; Tanvir Islam; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Yasunori Hayashi; Hitoshi Okamoto

  Scientific reports, 10 Jun. 2019, Peer-reviewed

  
• Drebrin-Homer Interaction at An Atomic Scale.

  Yasunori Hayashi

  Structure (London, England : 1993), 02 Jan. 2019

  
• Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.

  Karam Kim; Akio Suzuki; Hiroto Kojima; Meiko Kawamura; Ken Miya; Manabu Abe; Ikuko Yamada; Tamio Furuse; Shigenaru Wakana; Kenji Sakimura; Yasunori Hayashi

  Neurobiology of learning and memory, Jan. 2019, Peer-reviewed

  
• Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities.

  Erik I Hallin; Maria S Eriksen; Sergei Baryshnikov; Oleksii Nikolaienko; Sverre Grødem; Tomohisa Hosokawa; Yasunori Hayashi; Clive R Bramham; Petri Kursula

  Journal of neurochemistry, Nov. 2018, Peer-reviewed

  
• ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.

  Yurina Kashino; Yutaro Obara; Yosuke Okamoto; Takeo Saneyoshi; Yasunori Hayashi; Kuniaki Ishii

  International journal of molecular sciences, 10 Jul. 2018, Peer-reviewed

  
• Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities

  Hallin EI; Eriksen MS; Baryshnikov S; Nikolaienko O; Groedem S; Hosokawa T; Hayashi Y; Bramham CR; Kursula P

  May 2018, Peer-reviewed

  
• Dynamic embedding of salience coding in hippocampal spatial maps

  Sato M; Mizuta K; Islam T; Kawano M; Takekawa T; Gomez-Dominguez D; Kim K; Yamakawa H; Ohkura M; Fukai T; Nakai J; Hayashi Y

  Feb. 2018, Peer-reviewed

  
• CaMKII biophysics and its role in long-term potentiation

  Margaret Stratton; Ana Torres; Yasunori Hayashi; Takeo Saneyoshi; Emily Agnello; Rory O'connell; Brendan Page; Megan West

  PROTEIN SCIENCE, Dec. 2017, Peer-reviewed

  
• Building Bridges through Science.

  Thomas Lissek; Michelle Adams; John Adelman; Ehud Ahissar; Mohammed Akaaboune; Huda Akil; Mustafa al'Absi; Fazal Arain; Juan Carlos Arango-Lasprilla; Deniz Atasoy; Jesus Avila; Ashraf Badawi; Hilmar Bading; Abdul Mannan Baig; Jimena Baleriola; Carlos Belmonte; Ilaria Bertocchi; Heinrich Betz; Colin Blakemore; Olaf Blanke; Philipp Boehm-Sturm; Tobias Bonhoeffer; Paolo Bonifazi; Nils Brose; Patrizia Campolongo; Tansu Celikel; Cathy C Chang; Ta-Yuan Chang; Ami Citri; Hollis T Cline; Jesus M Cortes; Kathleen Cullen; Kellie Dean; José M Delgado-Garcia; Mathieu Desroches; John F Disterhoft; John E Dowling; Andreas Draguhn; Sherif F El-Khamisy; Abdeljabbar El Manira; S Ather Enam; Juan M Encinas; Asier Erramuzpe; José A Esteban; Isabel Fariñas; Edmond Fischer; Izumi Fukunaga; Iñigo Gabilondo; Detlev Ganten; Albert Gidon; Juan Carlos Gomez-Esteban; Paul Greengard; Valery Grinevich; Agnés Gruart; Roger Guillemin; Ahmad R Hariri; Bassem Hassan; Michael Häusser; Yasunori Hayashi; Natasha K Hussain; Adnan Abdul Jabbar; Mohamed Jaber; Reinhardt Jahn; Essam Mohammed Janahi; Mohamed Kabbaj; Helmut Kettenmann; Merel Kindt; Shira Knafo; Georg Köhr; Shoji Komai; Harm Krugers; Bernd Kuhn; Nouria Lakhdar Ghazal; Matthew E Larkum; Mickey London; Beat Lutz; Carlos Matute; Luis Martinez-Millan; Mouna Maroun; James McGaugh; Ahmed A Moustafa; Anwar Nasim; Klaus-Armin Nave; Erwin Neher; Karoly Nikolich; Tiago Outeiro; Lucy M Palmer; Olga Penagarikano; Isabel Perez-Otano; Donald W Pfaff; Bruno Poucet; Atta-Ur Rahman; Pedro Ramos-Cabrer; Ali Rashidy-Pour; Richard J Roberts; Serafim Rodrigues; Joshua R Sanes; Andreas T Schaefer; Menahem Segal; Idan Segev; Saad Shafqat; Nikhat Ahmed Siddiqui; Hermona Soreq; Eduardo Soriano-García; Rainer Spanagel; Rolf Sprengel; Greg Stuart; Thomas C Südhof; Jan Tønnesen; Mario Treviño; Basim M Uthman; J Craig Venter; Alexei Verkhratsky; Craig Weiss; Torsten N Wiesel; Emre Yaksi; Ofer Yizhar; Larry J Young; Paul Young; Nasser H Zawia; José L Zugaza; Mazahir T Hasan

  Neuron, 15 Nov. 2017, Peer-reviewed

  
• Automatic sorting system for large calcium imaging data

  Takekawa T; Asai H; Ohkawa N; Nomoto M; Okubo-Suzuki R; Ghandour K; Sato M; Hayashi Y; Inokuchi K; Fukai T

  Nov. 2017, Peer-reviewed

  
• Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses.

  Miquel Bosch; Jorge Castro; Mriganka Sur; Yasunori Hayashi

  Methods in molecular biology (Clifton, N.J.), 2017, Peer-reviewed

  
• Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality.

  Yasunori Hayashi

  eNeuro, 2017, Peer-reviewed

  
• Interplay of enzymatic and structural functions of CaMKII in long-term potentiation.

  Yasunori Hayashi

  Journal of neurochemistry, Dec. 2016, Peer-reviewed

  
• In vivo two-photon imaging of striatal neuronal circuits in mice.

  Masaaki Sato; Masako Kawano; Yuchio Yanagawa; Yasunori Hayashi

  Neurobiology of learning and memory, Nov. 2016, Peer-reviewed

  
• A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII.

  Yasunori Hayashi

  Neuron, Oct. 2015, Peer-reviewed

  
• A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII.

  Yasunori Hayashi

  Neuron, Aug. 2015, Peer-reviewed

  
• A Top-Down Cortical Circuit for Accurate Sensory Perception.

  Yasunori Hayashi

  Neuron, Jun. 2015, Peer-reviewed

  
• Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice

  Masanori Sakaguchi; Karam Kim; Lily Mae Yee Yu; Yoshiko Hashikawa; Yukiko Sekine; Yuki Okumura; Masako Kawano; Masanobu Hayashi; Deependra Kumar; Edward S. Boyden; Thomas J. McHugh; Yasunori Hayashi

  PLOS ONE, Jun. 2015, Peer-reviewed

  
• Generation and Imaging of Transgenic Mice that Express G-CaMP7 under a Tetracycline Response Element

  Masaaki Sato; Masako Kawano; Masamichi Ohkura; Keiko Gengyo-Ando; Junichi Nakai; Yasunori Hayashi

  PLOS ONE, May 2015, Peer-reviewed

  
• A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia.

  Yasunori Hayashi

  PloS one, 2015, Peer-reviewed

  
• Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylation.

  Yasunori Hayashi

  Neuron, Jan. 2015, Peer-reviewed

  
• CaMKII: the Swiss army knife of synaptic plasticity

  Karam Kim; Yasunori Hayashi

  JOURNAL OF PHYSIOLOGY-LONDON, Nov. 2014, Peer-reviewed

  
• Activation of Sodium-Dependent Glutamate Transporters Regulates the Morphological Aspects of Oligodendrocyte Maturation via Signaling through Calcium/Calmodulin-Dependent Kinase II beta's Actin-Binding/-Stabilizing Domain

  Zila Martinez-Lozada; Christopher T. Waggener; Karam Kim; Shiping Zou; Pamela E. Knapp; Yasunori Hayashi; Arturo Ortega; Babette Fuss

  GLIA, Sep. 2014, Peer-reviewed

  
• Synapse reorganization-a new partnership revealed

  Takeo Saneyoshi; Yasunori Hayashi

  EMBO JOURNAL, Jun. 2014, Peer-reviewed

  
• Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

  Miquel Bosch; Jorge Castro; Takeo Saneyoshi; Hitomi Matsuno; Mriganka Sur; Yasunori Hayashi

  NEURON, Apr. 2014, Peer-reviewed

  
• Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.

  Matsuyama M; Tanaka H; Inoko A; Goto H; Yonemura S; Kobori K; Hayashi Y; Kondo E; Itohara S; Izawa I; Inagaki M

  The Journal of biological chemistry, Dec. 2013, Peer-reviewed

  
• Application of FRET probes in the analysis of neuronal plasticity

  Yoshibumi Ueda; Showming Kwok; Yasunori Hayashi

  FRONTIERS IN NEURAL CIRCUITS, Oct. 2013, Peer-reviewed

  
• PIP3 regulates Spinule formation in dendritic spines during structural long-term potentiation

  Yoshibumi Ueda; Yasunori Hayashi

  Journal of Neuroscience, 2013, Peer-reviewed

  
• Catching the engram: strategies to examine the memory trace

  Masanori Sakaguchi; Yasunori Hayashi

  MOLECULAR BRAIN, Sep. 2012, Peer-reviewed

  
• The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines

  Takeo Saneyoshi; Yasunori Hayashi

  CYTOSKELETON, Aug. 2012, Peer-reviewed

  
• Structural plasticity of dendritic spines

  Miguel Bosch; Yasunori Hayashi

  CURRENT OPINION IN NEUROBIOLOGY, Jun. 2012, Peer-reviewed

  
• Roles of Neuronal Activity-Induced Gene Products in Hebbian and Homeostatic Synaptic Plasticity, Tagging, and Capture

  Yasunori Hayashi; Ken-ichi Okamoto; Miguel Bosch; Kensuke Futai

  SYNAPTIC PLASTICITY: DYNAMICS, DEVELOPMENT AND DISEASE, 2012, Peer-reviewed

  
• A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes.

  Dan Ohtan Wang; Hitomi Matsuno; Shuji Ikeda; Akiko Nakamura; Hiroyuki Yanagisawa; Yasunori Hayashi; Akimitsu Okamoto

  RNA (New York, N.Y.), Jan. 2012, Peer-reviewed

  
• Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo

  Amanda F. Mower; Showming Kwok; Hongbo Yu; Ania K. Majewska; Ken-Ichi Okamoto; Yasunori Hayashi; Mriganka Sur

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2011, Peer-reviewed

  
• A novel FISH method detecting single mismatches under 25 minutes

  Dan Wang; Hitomi Matsuno; Shuji Ikeda; Yasunori Hayashi; Akimitsu Okamoto

  NEUROSCIENCE RESEARCH, 2011, Peer-reviewed

  
• A quantitative analysis of AMPA receptor GluR1 phospho-isotypes

  Tomohisa Hosokawa; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2011, Peer-reviewed

  
• Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection.

  Malinow R; Hayashi Y; Maletic-Savatic M; Zaman SH; Poncer JC; Shi SH; Esteban JA; Osten P; Seidenman K

  Cold Spring Harbor protocols, Apr. 2010, Peer-reviewed

  
• Structural plasticity mediated by CaMKII

  Karam Kim; Kenichi Okamoto; Kaoru Matsuura; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2010, Peer-reviewed

  
• The Roles of CaMKII and F-Actin in the Structural Plasticity of Dendritic Spines: A Potential Molecular Identity of a Synaptic Tag?

  Kenichi Okamoto; Miquel Bosch; Yasunori Hayashi

  PHYSIOLOGY, Dec. 2009, Peer-reviewed

  
• The Roles of CaMKII and F-Actin in the Structural Plasticity of Dendritic Spines: A Potential Molecular Identity of a Synaptic Tag?

  Kenichi Okamoto; Miquel Bosch; Yasunori Hayashi

  PHYSIOLOGY, Dec. 2009, Peer-reviewed

  
• Long-term potentiation: two pathways meet at neurogranin

  Yasunori Hayashi

  EMBO JOURNAL, Oct. 2009, Peer-reviewed

  
• Functional Dynamics of Polo-Like Kinase 1 at the Centrosome

  Kazuhiro Kishi; Marcel A. T. M. van Vugt; Ken-ichi Okamoto; Yasunori Hayashi; Michael B. Yaffe

  MOLECULAR AND CELLULAR BIOLOGY, Jun. 2009, Peer-reviewed

  
• The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

  Mariko Kato Hayashi; Chunyan Tang; Chiara Verpelli; Radhakrishnan Narayanan; Marissa H. Stearns; Rui-Ming Xu; Huilin Li; Carlo Sala; Yasunori Hayashi

  CELL, Apr. 2009, Peer-reviewed

  
• Asian promise: the state and future of collaborations in neuroscience

  Mu-Ming Poo; Ley Sander; Marc Fivaz; Yasunori Hayashi

  NATURE REVIEWS NEUROSCIENCE, Nov. 2008, Peer-reviewed

  
• Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity

  Showining Kwok; Claudia Lee; Susana A. Sanchez; Theodore L. Hazlett; Enrico Gratton; Yasunori Hayashi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2008, Peer-reviewed

  
• Motoneuron-specific NR3B gene - No association with ALS and evidence for a common null allele

  S. Niemann; J. E. Landers; M. J. Churchill; B. Hosler; P. Sapp; W. C. Speed; B. T. Lahn; K. K. Kidd; R. H. Brown; Y. Hayashi

  NEUROLOGY, Feb. 2008, Peer-reviewed

  
• Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95 (vol 56, pg 488, 2007)

  Myung Jong Kim; Kensulke Futai; Jihoon Jo; Yasunori Hayashi; Kwangwook Cho; Morgan Sheng

  NEURON, Jan. 2008, Peer-reviewed

  
• Erratum to "Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity" [Biochem. Biophys. Res. Commun. 369 (2008) 519-525] (DOI:10.1016/j.bbrc.2008.02.070)

  Kwok S; Lee C; Sánchez S.A; Hazlett T.L; Gratton E; Hayashi Y

  Biochemical and Biophysical Research Communications, 2008, Peer-reviewed

  
• Corrigendum: Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin (Nature Neuroscience (2007) 10 (186-195))

  Futai K; Jong Kim M; Hashikawa T; Scheiffele P; Sheng M; Hayashi Y

  Nature Neuroscience, 2008, Peer-reviewed

  
• Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95

  Myung Jong Kim; Kensuke Futai; Jihoon Jo; Yasunori Hayashi; Kwangwook Cho; Morgan Sheng

  NEURON, Nov. 2007, Peer-reviewed

  
• Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes

  Stephan Niemann; Hiroaki Kanki; Yasuyuki Fukui; Keizo Takao; Masahiro Fukaya; Meri N. Hynynen; Michael J. Churchill; Jeremy M. Shefner; Roderick T. Bronson; Robert H. Brown; Masahiko Watanabe; Tsuyoshi Miyakawa; Shigeyoshi Itohara; Yasunori Hayashi

  EUROPEAN JOURNAL OF NEUROSCIENCE, Sep. 2007, Peer-reviewed

  
• The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure

  Ken-Ichi Okamoto; Radhakrishnan Narayanan; Sang H. Lee; Kazuyoshi Murata; Yasunori Hayashi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2007, Peer-reviewed

  
• Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin

  Kensuke Futai; Myung Jong Kim; Tsutomu Hashikawa; Peter Scheiffele; Morgan Sheng; Yasunori Hayashi

  NATURE NEUROSCIENCE, Feb. 2007, Peer-reviewed

  
• Tetrameric hub structure of postsynaptic scaffolding protein Homer

  Mariko Kato Hayashi; Heather M. Ames; Yasunori Hayashi

  JOURNAL OF NEUROSCIENCE, Aug. 2006, Peer-reviewed

  
• Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina

  Y Munemasa; R Ohtani-kaneko; Y Kitaoka; T Kumai; Y Kitaoka; Y Hayashi; M Watanabe; H Takeda; K Hirata; S Ueno

  JOURNAL OF NEUROSCIENCE RESEARCH, Apr. 2006, Peer-reviewed

  
• Visualization of F-actin and G-actin equilibrium using fluorescence resonance energy transfer (FRET) in cultured cells and neurons in slices

  Ken-Ichi Okamoto; Yasunori Hayashi

  NATURE PROTOCOLS, 2006, Peer-reviewed

  
• QZ1 and QZ2: Rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II)

  EM Nolan; J Jaworski; KI Okamoto; Y Hayashi; M Sheng; SJ Lippard

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2005, Peer-reviewed

  
• Targeting quantum dots to surface proteins in living cells with biotin ligase

  M Howarth; K Takao; Y Hayashi; AY Ting

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2005, Peer-reviewed

  
• Dendritic spine geometry: Functional implication and regulation

  Y Hayashi; AK Majewska

  NEURON, May 2005, Peer-reviewed

  
• Visualization of synaptic Ca2+/calmodulin-dependent protein kinase II activity in living neurons

  K Takao; KI Okamoto; T Nakagawa; RL Neve; T Nagai; A Miyawaki; T Hashikawa; S Kobayashi; Y Hayashi

  JOURNAL OF NEUROSCIENCE, Mar. 2005, Peer-reviewed

  
• NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons.

  Fukaya M; Hayashi Y; Watanabe M

  The European journal of neuroscience, Mar. 2005, Peer-reviewed

  
• The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

  Z Li; K Okamoto; Y Hayashi; M Sheng

  CELL, Dec. 2004, Peer-reviewed

  
• Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity

  KI Okamoto; T Nagai; A Miyawaki; Y Hayashi

  NATURE NEUROSCIENCE, Oct. 2004, Peer-reviewed

  
• ZP8, a neuronal zinc sensor with improved dynamic range; Imaging zinc in hippocampal slices with two-photon microscopy

  CJ Chang; EM Nolan; J Jaworski; KI Okamoto; Y Hayashi; M Sheng; SJ Lippard

  INORGANIC CHEMISTRY, Oct. 2004, Peer-reviewed

  
• Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions

  T Nakagawa; K Futai; HA Lashuel; Lo, I; K Okamoto; T Walz; Y Hayashi; M Sheng

  NEURON, Oct. 2004, Peer-reviewed

  
• Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold

  CE Semino; J Kasahara; Y Hayashi; SG Zhang

  TISSUE ENGINEERING, Mar. 2004, Peer-reviewed

  
• Characterization of novel bicistronic Sindbis virus vectors, SinEGdsp and SinIRES-EG, in cultured neurons

  Kawamura M; Namba H; Otsu Y; Hayashi Y; Takei N; Nawa H

  Recent Res. Devel. Neurochem., Dec. 2003, Peer-reviewed

  
• Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons

  H Jourdi; Y Iwakura; M Narisawa-Saito; K Ibaraki; HB Xiong; M Watanabe; Y Hayashi; N Takei; H Nawa

  DEVELOPMENTAL BIOLOGY, Nov. 2003, Peer-reviewed

  
• Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein homer1a

  C Sala; K Futai; K Yamamoto; PF Worley; Y Hayashi; M Sheng

  JOURNAL OF NEUROSCIENCE, Jul. 2003, Peer-reviewed

  
• Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

  SH Shi; Y Hayashi; JA Esteban; R Malinow

  CELL, May 2001, Peer-reviewed

  
• Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity

  JJ Zhu; JA Esteban; Y Hayashi; R Malinow

  NATURE NEUROSCIENCE, Nov. 2000, Peer-reviewed

  
• LTP mechanisms: from silence to four-lane traffic

  R Malinow; ZF Mainen; Y Hayashi

  CURRENT OPINION IN NEUROBIOLOGY, Jun. 2000, Peer-reviewed

  
• Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction

  Y Hayashi; SH Shi; JA Esteban; A Piccini; JC Poncer; R Malinow

  SCIENCE, Mar. 2000, Peer-reviewed

  
• Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1

  WA Carlezon; CN Haile; R Coopersmith; Y Hayashi; R Malinow; RL Neve; EJ Nestler

  JOURNAL OF NEUROSCIENCE, Mar. 2000, Peer-reviewed

  
• Erratum: Postnatal synaptic potentiation: Delivery of glur4-containing ampa receptors by spontaneous activity (nature neuroscience (2000) 3 (1098-1106))

  Zhu J.J; Esteban J.A; Hayashi Y; Malinow R

  Nature Neuroscience, 2000, Peer-reviewed

  
• Two-photon imaging in living brain slices

  ZF Mainen; M Maletic-Savatic; SH Shi; Y Hayashi; R Malinow; K Svoboda

  METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, Jun. 1999, Peer-reviewed

  
• Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation

  SH Shi; Y Hayashi; RS Petralia; SH Zaman; RJ Wenthold; K Svoboda; R Malinow

  SCIENCE, Jun. 1999, Peer-reviewed

  
• Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density

  Y Hayashi; A Ishida; H Katagiri; M Mishina; H Fujisawa; T Manabe; T Takahashi

  MOLECULAR BRAIN RESEARCH, Jun. 1997, Peer-reviewed

  
• Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

  N Sekiyama; Y Hayashi; S Nakanishi; DE Jane; HW Tse; EF Birse; JC Watkins

  BRITISH JOURNAL OF PHARMACOLOGY, Apr. 1996, Peer-reviewed

  
• Role of a metabotropic glutamate receptor in the formation of an olfactory memory

  H Kaba; F Okutani; Y Hayashi; T Kiguchi; S Nakanishi

  CHEMICAL SIGNALS IN VERTEBRATES VII, 1995, Peer-reviewed

  
• INDUCTION OF AN OLFACTORY MEMORY BY THE ACTIVATION OF A METABOTROPIC GLUTAMATE-RECEPTOR

  H KABA; Y HAYASHI; T HIGUCHI; S NAKANISHI

  SCIENCE, Jul. 1994, Peer-reviewed

  
• MOLECULAR DIVERSITY AND PHYSIOLOGICAL FUNCTIONS OF GLUTAMATE RECEPTORS

  S NAKANISHI; M MASU; Y BESSHO; Y NAKAJIMA; Y HAYASHI; A NOMURA; R SHIGEMOTO

  NEUROPSYCHOPHARMACOLOGY, May 1994, Peer-reviewed

  
• ANALYSIS OF AGONIST AND ANTAGONIST ACTIVITIES OF PHENYLGLYCINE DERIVATIVES FOR DIFFERENT CLONED METABOTROPIC GLUTAMATE-RECEPTOR SUBTYPES

  Y HAYASHI; N SEKIYAMA; S NAKANISHI; DE JANE; DC SUNTER; EF BIRSE; PM UDVARHELYI; JC WATKINS

  JOURNAL OF NEUROSCIENCE, May 1994, Peer-reviewed

  
• MOLECULAR DIVERSITY OF GLUTAMATE RECEPTORS AND THEIR PHYSIOLOGICAL FUNCTIONS

  S NAKANISHI; M MASU; Y BESSHO; Y NAKAJIMA; Y HAYASHI; R SHIGEMOTO

  TOWARD A MOLECULAR BASIS OF ALCOHOL USE AND ABUSE, 1994, Peer-reviewed

  
• MOLECULAR CHARACTERIZATION OF A NEW METABOTROPIC GLUTAMATE-RECEPTOR MGLUR7 COUPLED TO INHIBITORY CYCLIC-AMP SIGNAL-TRANSDUCTION

  N OKAMOTO; S HORI; C AKAZAWA; Y HAYASHI; R SHIGEMOTO; N MIZUNO; S NAKANISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1994, Peer-reviewed

  
• ROLE OF A METABOTROPIC GLUTAMATE-RECEPTOR IN SYNAPTIC MODULATION IN THE ACCESSORY OLFACTORY-BULB

  Y HAYASHI; A MOMIYAMA; T TAKAHASHI; H OHISHI; R OGAWAMEGURO; R SHIGEMOTO; N MIZUNO; S NAKANISHI

  NATURE, Dec. 1993, Peer-reviewed

  
• Structure and function of prostanoid receptors.

  NARUMIYA S; HIRATA N; NAMBA T; HAYASHI Y; USHIKUBI F; SUGIMOTO Y; NEGISHI M; ICHIKAWA A

  J Lipid Mediat, Mar. 1993, Peer-reviewed

  
• 2 ISOFORMS OF THE EP3 RECEPTOR WITH DIFFERENT CARBOXYL-TERMINAL DOMAINS - IDENTICAL LIGAND-BINDING PROPERTIES AND DIFFERENT COUPLING PROPERTIES WITH G(I) PROTEINS

  Y SUGIMOTO; M NEGISHI; Y HAYASHI; T NAMBA; A HONDA; A WATABE; M HIRATA; S NARUMIYA; A ICHIKAWA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1993, Peer-reviewed

  
• FUNCTIONAL INTERACTION OF PROSTAGLANDIN-E RECEPTOR EP3 SUBTYPE WITH GUANINE NUCLEOTIDE-BINDING PROTEINS, SHOWING LOW-AFFINITY LIGAND-BINDING

  M NEGISHI; Y SUGIMOTO; Y HAYASHI; T NAMBA; A HONDA; A WATABE; S NARUMIYA; A ICHIKAWA

  BIOCHIMICA ET BIOPHYSICA ACTA, Feb. 1993, Peer-reviewed

  
• AGONIST ANALYSIS OF 2-(CARBOXYCYCLOPROPYL)GLYCINE ISOMERS FOR CLONED METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES EXPRESSED IN CHINESE-HAMSTER OVARY CELLS

  Y HAYASHI; Y TANABE; ARAMORI, I; M MASU; K SHIMAMOTO; Y OHFUNE; S NAKANISHI

  BRITISH JOURNAL OF PHARMACOLOGY, Oct. 1992, Peer-reviewed

  
• MOUSE THROMBOXANE-A2 RECEPTOR - CDNA CLONING, EXPRESSION AND NORTHERN BLOT ANALYSIS

  T NAMBA; Y SUGIMOTO; M HIRATA; Y HAYASHI; A HONDA; A WATABE; M NEGISHI; A ICHIKAWA; S NARUMIYA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 1992, Peer-reviewed

  
• CLONING AND EXPRESSION OF A CDNA FOR MOUSE PROSTAGLANDIN-E RECEPTOR EP(3) SUBTYPE

  Y SUGIMOTO; T NAMBA; A HONDA; Y HAYASHI; M NEGISHI; A ICHIKAWA; S NARUMIYA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1992, Peer-reviewed

  
• DESENSITIZATION BY GLYCYRRHETINIC ACID OF OTHER STIMULATORY SUBSTANCE-INDUCED INCREASES IN INTRACELLULAR CALCIUM IN A VARIETY OF CELL-TYPES

  Y HAYASHI; S HIRAI; M NEGISHI; T OKUMURA; A ICHIKAWA

  BIOCHEMICAL PHARMACOLOGY, Jun. 1991, Peer-reviewed

  
• CLONING AND EXPRESSION OF CDNA FOR A HUMAN THROMBOXANE-A2 RECEPTOR

  M HIRATA; Y HAYASHI; F USHIKUBI; Y YOKOTA; R KAGEYAMA; S NAKANISHI; S NARUMIYA

  NATURE, Feb. 1991, Peer-reviewed

  
• ENHANCEMENT OF INVIVO TYROSINE HYDROXYLATION IN THE RAT ADRENAL-GLAND UNDER HYPOXIC CONDITIONS

  Y HAYASHI; S MIWA; K LEE; K KOSHIMURA; K HAMAHATA; H HASEGAWA; M FUJIWARA; Y WATANABE

  JOURNAL OF NEUROCHEMISTRY, Apr. 1990, Peer-reviewed

  
• EFFECTS OF CHOLINE ADMINISTRATION ON INVIVO RELEASE AND BIOSYNTHESIS OF ACETYLCHOLINE IN THE RAT STRIATUM AS STUDIED BY INVIVO BRAIN MICRODIALYSIS

  K KOSHIMURA; S MIWA; K LEE; Y HAYASHI; H HASEGAWA; K HAMAHATA; M FUJIWARA; M KIMURA; Y ITOKAWA

  JOURNAL OF NEUROCHEMISTRY, Feb. 1990, Peer-reviewed

  
• EFFECTS OF HYPOXIA ON NORADRENALINE RELEASE AND NEURONAL REUPTAKE IN ISOLATED RABBIT THORACIC AORTIC STRIPS

  K LEE; S MIWA; Y HAYASHI; K KOSHIMURA; M FUJIWARA; Y ORII

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, May 1989, Peer-reviewed

  
• EFFECTS OF HYPOXIA ON CONTRACTILE RESPONSES OF RABBIT AORTIC STRIPS TO TRANSMURAL ELECTRICAL-STIMULATION

  K LEE; S MIWA; Y HAYASHI; K KOSHIMURA; T TANIGUCHI; Y ORII; M FUJIWARA

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Sep. 1988, Peer-reviewed

  
• A NONISOTOPIC METHOD FOR DETERMINATION OF THE INVIVO ACTIVITIES OF TYROSINE-HYDROXYLASE IN THE RAT ADRENAL-GLAND

  Y HAYASHI; S MIWA; K LEE; K KOSHIMURA; A KAMEI; K HAMAHATA; M FUJIWARA

  ANALYTICAL BIOCHEMISTRY, Jan. 1988, Peer-reviewed

  
• Molecular mechanism of hippocampal long-term potentiation – Towards multiscale understanding of learning and memory

  Yasunori Hayashi

  Neuroscience Research, Feb. 2022

  
• Stepwise synaptic plasticity events drive the early phase of memory consolidation

  Akihiro Goto; Ayaka Bota; Ken Miya; Jingbo Wang; Suzune Tsukamoto; Xinzhi Jiang; Daichi Hirai; Masanori Murayama; Tomoki Matsuda; Thomas J. McHugh; Takeharu Nagai; Yasunori Hayashi

  SCIENCE, Nov. 2021

  

Misc.

• 光によるシナプス可塑性制御で明らかになった記憶固定化機構

  後藤明弘; 林康紀

  生物物理 (日本生物物理学会), 25 Jul. 2022, Peer-reviewed

  
• In vivo two-photon imaging of neuronal circuit activity using transgenic mice that express fluorescent calcium sensor proteins in the brain

  Masaaki Sato; Masako Kawamo; Tanvir Islam; Yoko Yamaguchi; Masamichi Ohkura; Junichi Nakai; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2011

  
• In vivo two-photon imaging of hippocampal circuit structure and function in mice

  Masaaki Sato; Masako Kawano; Junichi Nakai; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2010

  
• The postsynaptic density proteins homer and shank form a polymeric network structure

  Mariko Hayashi; Chunyan Tang; Chiara Verpelli; Radhakrishnan Narayanan; Marissa Stearns; Rui-Ming Xu; Huilin Li; Carlo Sala; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2010

  
• The postsynaptic density proteins homer and shank form a polymeric network structure

  Mariko Hayashi; Chunyan Tang; Chiara Verpelli; Radhakrishnan Narayanan; Marissa Stearns; Rui-Ming Xu; Carlo Sala; Yasunori Hayashi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity (vol 369, pg 519, 2008)

  Showming Kwok; Claudia Lee; Susana A. Sanchez; Theodore L. Hazlett; Enrico Gratton; Yasunori Hayashi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2008

  
• Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin (vol 10, pg 186, 2007)

  Kensuke Futai; Myung Jong Kim; Tsutomu Hashikawa; Peter Scheiffele; Morgan Sheng; Yasunori Hayashi

  NATURE NEUROSCIENCE, Feb. 2008

  
• INOR 1009-Analogs of Zinpyr-1 afford insight into the zinc sensing mechanism and enable selective imaging of the synaptic vesicles in hippocampal neurons

  Christian R. Goldsmith; Ken-Ichi Okamoto; Yasunori Hayashi; Stephen J. Lippard

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006

  
• Role of CaMKII as a structural protein that stabilizes actin cytoskeleton in dendritic spines

  Kenichi Okamoto; Radhakrishnan Narayanan; Yasunori Hayashi

  NEUROSCIENCE RESEARCH, 2006

  
• Regulation of AMPA receptor trafficking by delta-catenin

  Tomoyo Ochiishi; Kensuke Futai; Kenichi Okamoto; Kimihiko Kameyama; Yasunori Hayashi; Kenneth S. Kosik

  NEUROSCIENCE RESEARCH, 2006

  
• Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity (vol 3, pg 1098, 2000)

  JJ Zhu; JA Esteban; Y Hayashi; R Malinow

  NATURE NEUROSCIENCE, Dec. 2000

  
• MOLECULAR CHARACTERIZATION OF A NEW METABOTROPIC GLUTAMATE-RECEPTOR MGLUR7 COUPLED TO INHIBITORY CYCLIC-AMP SIGNAL-TRANSDUCTION

  N OKAMOTO; S HORI; C AKAZAWA; Y HAYASHI; R SHIGEMOTO; N MIZUNO; Y HONDA; S NAKANISHI

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Mar. 1994

  
• EFFECTS OF HYPOXIA ON MECHANISMS OF ADRENERGIC TRANSMISSION AND CONTRACTION OF RABBIT AORTA

  K LEE; S MIWA; Y HAYASHI; T TANIGUCHI; M FUJIWARA

  JAPANESE JOURNAL OF PHARMACOLOGY, 1987

  
• EFFECTS OF HYPOXIA ON TURNOVER RATES OF DOPAMINE, 3,4-DIHYDROXYPHENYLACETIC ACID AND 3-METHOXYTYRAMINE IN THE RAT STRIATUM

  S MIWA; K LEE; Y HAYASHI; M FUJIWARA

  JAPANESE JOURNAL OF PHARMACOLOGY, 1987

  

Presentations

• Molecular mechanism of structural plasticity of dendritic spine

  Yasunori Hayashi

  Universidad autonoma de Madrid, Spain, Jul. 2011, Invited

  
• Phosphoisotype analysis of AMPA receptor GluR1

  Yasunori Hayashi

  Gordon Research Conference Excitatory Synapsese & Brain Function, Jun. 2011

  

External funds: Kakenhi

• Regulatory mechanism of synaptic plasticity through liquid-liquid phase separation of CaMKII

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 46:Neuroscience and related fields

  Kyoto University

  Yasunori HAYASHI

  From 30 Jul. 2020, To 31 Mar. 2022, Project Closed

  CaMKII;シナプス可塑性;液-液相分離;AMPA型グルタミン酸受容体;NMDA型グルタミン酸受容体;興奮性シナプス;PSD-95;液－液相分離;シナプス後膜肥厚;Ca2+/カルモジュリン依存性蛋白質キナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21462/
• Circuit mechanism of spatial context information processing

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 46:Neuroscience and related fields

  Kyoto University

  Yasunori Hayashi

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  記憶固定化;記憶痕跡;空間記憶;前帯状皮質;海馬;空間文脈細胞;場所情報;カルシウムイメージング;場所細胞;記憶学習;抽象化;大脳皮質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01010/
• シナプス操作によるPTSDの構成的理解

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  林 康紀

  From 29 Jun. 2018, To 31 Mar. 2023, Granted

  記憶固定化;シナプス可塑性;大脳皮質;海馬;記憶痕跡;PTSD;恐怖記憶;記憶再固定化;光増感法;コフィリン;前頭前野;光操作;外傷後ストレス症候群;記憶学習;カルシウムイメージング;シナプス光操作;CALI;細胞骨格

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18H05434/
• マルチスケール精神病態の構成的理解（総括班）

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Institute of Physical and Chemical Research;Gunma University

  高木 朗子; 林朗子;林 朗子; 高木朗子

  From 29 Jun. 2018, To 31 Mar. 2023, Granted

  マルチスケール;マイクロ精神病態;構成的理解;モデリング;トランスオミクス;精神疾患;種間横断比較;シミュレーション

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18H05428/
• 光による特定の神経細胞への記憶のエンコーディング

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  林 康紀

  From 01 Apr. 2018, To 31 Mar. 2019, Discontinued

  記憶;光活性化タンパク質;CREB;核移行シグナル;Ca2+/カルモジュリン依存性キナーゼIV;LOV2ドメイン;記憶学習;CaMIV;シナプス可塑性;光活性化蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04733/
• Role of hippocampal predictive firing in decision making

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  Yasunori Hayashi

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  光活性化蛋白質;記憶・学習;スパイン;興奮性シナプス;CREB;CaMKIV;光プローブ;行動予想発火;海馬;意思決定;光活性化タンパク質;場所細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19631/
• Neural circuit mechanism to determine hippocampal brain state

  Grant-in-Aid for Challenging Exploratory Research

  Institute of Physical and Chemical Research

  Yasunori Hayashi

  From 01 Apr. 2016, To 31 Mar. 2017, Project Closed

  セロトニン;縫線核;記憶学習;海馬;脳状態;カルシウムイメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14562/
• Time-window of NMDA receptor-dependent LTP during memory formation, consolidation and recall

  Grant-in-Aid for Scientific Research (A)

  Kyoto University;Institute of Physical and Chemical Research

  Yasunori Hayashi

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  シナプス可塑性;記憶・学習;コフィリン;スパイン;記憶固定化;樹状突起スパイン;細胞骨格;光増感法;記憶学習;長期記憶;海馬;記憶痕跡;睡眠

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02455/
• NMDA受容体依存性LTPの制御のための光プローブの作成

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University;Institute of Physical and Chemical Research

  林 康紀

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  細胞骨格;シナプス可塑性;記憶固定化;長期記憶;光増感法;コフィリン;記憶・学習;樹状突起スパイン;LOVドメイン;CREB;光プローブ;光分子不活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01438/
• 記憶形成、固定、想起における海馬背側CA1セルアセンブリの長期可視化

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University;Institute of Physical and Chemical Research

  林 康紀

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  記憶学習;報酬;セルアセンブリ;仮想現実空間;二光子顕微鏡;海馬;記憶痕跡;記憶固定化;カルシウムイメージング;報酬学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01292/
• シナプス可塑性の基盤となるカルシウムシグナルの可視化

  Grant-in-Aid for JSPS Fellows

  Institute of Physical and Chemical Research

  From 27 Jul. 2016, To 31 Mar. 2019, Project Closed

  Fluorescent protein;FRET;LTP;N-WASP;Calcium signalling;Long term potentiation;Biosensors;Protein engineering

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16F16712/
• Why there are multiple synaptic adhesion molecules in single synapse? - Nanodomain hypothesis

  Grant-in-Aid for Challenging Exploratory Research

  Institute of Physical and Chemical Research

  Yasunori Hayashi

  From 01 Apr. 2015, To 31 Mar. 2016, Project Closed

  シナプス;細胞接着因子;超高解像度顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14330/
• Visualization of maternal separation memory engram and retrieval by activating positive memory engram

  Grant-in-Aid for Scientific Research (B)

  Nara Medical University

  Mayumi Nishi

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  記憶の痕跡;光遺伝学;幼児虐待;c-fos遺伝子プロモーター;ストレス;HPA-axis;養育行動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04671/
• 記憶形成の感情によるゲートの神経メカニズム

  Grant-in-Aid for JSPS Fellows

  Institute of Physical and Chemical Research

  From 24 Apr. 2015, To 31 Mar. 2017, Project Closed

  セロトニン;in vivo イメージング;バーチャルリアリティー;海馬;バーチャルリアリティ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15F14409/
• Role of clonally-related neurons in hippocampal neuronal circuit

  Grant-in-Aid for Challenging Exploratory Research

  The Institute of Physical and Chemical Research

  Yasunori HAYASHI

  From 01 Apr. 2014, To 31 Mar. 2015, Project Closed

  神経科学;脳・神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26640020/
• Optogenetic approach of gene regulation

  Grant-in-Aid for Challenging Exploratory Research

  The Institute of Physical and Chemical Research

  Yasunori HAYASHI

  From 01 Apr. 2011, To 31 Mar. 2012, Project Closed

  遺伝子発現;Cre;LOVドメイン;光遺伝学;Creレコンビナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650172/
• Effects of early life stress on brain plasticity

  Grant-in-Aid for Scientific Research (B)

  Nara Medical University

  Mayumi NISHI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  母子分離;ストレス;c-Fos;コルチコステロイド;扁桃体延長領域;視床下部―下垂体―副腎系;ペリニューロナルネット;エンドカンナビノイド;視床下部ー下垂体ー副腎系;臨界期;分界条床核;扁桃体中心核;PTSD;馴化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390040/
• Development of deep brain imaging technology in behaving animals: stability and instability of neuronal circuit under physiological and pathophysiological conditions

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The Institute of Physical and Chemical Research

  Yasunori HAYASHI

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  海馬;記憶;神経細胞集成体;シナプス可塑性;神経科学;脳・神経;樹状突起スパイン;二光子顕微鏡;記憶・学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22110006/
• 睡眠中の海馬活性化の記憶固定に於ける意義

  Grant-in-Aid for Challenging Exploratory Research

  The Institute of Physical and Chemical Research

  林 康紀

  From 01 Apr. 2009, To 31 Mar. 2010, Project Closed

  記憶学習;海馬;光作動性チャネル;睡眠;再活性化;マウス;ウイルスベクター;子宮内穿孔法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21650080/
• Molecular mechanisms of structural plasticity of dendritic spine

  Grant-in-Aid for Scientific Research (A)

  The Institute of Physical and Chemical Research

  Yasunori HAYASHI

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  細胞・組織;シグナル伝達;神経科学;生理学;脳・神経;記憶学習;シナプス可塑性;樹状突起スパイン;CaMKII;細胞骨格;海馬;記憶・学習;海馬長期増強現象;カルシウムカルモジュリン依存性蛋白質リン酸化酵素;アクチン;コフィリン;樹上突起棘;カルシウム;カルモジュリン依存性蛋白質リン酸化酵素(CaMKII);海馬スライス;二光子レーザー顕微鏡;長期増強現象;CaMKll;細胞情報伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20240032/
• Cellular representation of abstractive space "spatial context cells" - their formation and role in long-term memory

  Grant-in-Aid for Scientific Research (S)

  Broad Section G

  Kyoto University

  林 康紀

  From 27 Apr. 2022, To 31 Mar. 2027, Granted

  記憶固定化;シナプス可塑性;大脳皮質;海馬;記憶痕跡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04981/
• 空間概念の細胞表現「空間文脈細胞」の形成機構と長期空間記憶における役割

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 46:Neuroscience and related fields

  Kyoto University

  林 康紀

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  記憶固定化;シナプス可塑性;大脳皮質;海馬;記憶痕跡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00434/
• マイクロ流体デバイス内でのシナプス記憶の再構成

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 46:Neuroscience and related fields

  Kyoto University

  林 康紀

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  記憶固定化;シナプス可塑性;液-液相分離;CaMKII;マイクロ流体デバイス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19361/
• 新規発見された長期空間記憶の細胞表現「空間文脈細胞」の形成機構と役割

  Grant-in-Aid for JSPS Fellows

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  From 28 Sep. 2022, To 31 Mar. 2025, Granted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22F22753/
• 記憶メカニズムの多次元解析 - nmからメゾスケール/ミリ秒から日スケールまで

  Fund for the Promotion of Joint International Research (International Leading Research )

  Biological Sciences

  Kyoto University

  林 康紀

  From 20 Dec. 2022, To 31 Mar. 2029, Granted

  記憶;シナプス可塑性;神経回路

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K21353/
• 新規発見された長期空間記憶の細胞表現「空間文脈細胞」の形成機構と役割

  Grant-in-Aid for JSPS Fellows

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  From 08 Mar. 2023, To 31 Mar. 2025, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0211/

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology Laboratory Class and Tutorial

  B017, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology

  M009, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology I

  E015, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology

  B016, Spring, Faculty of Medicine, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology II

  E016, Spring, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacology

  B016, Spring, Faculty of Medicine, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  1035, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacology II

  E016, Spring, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacology I

  E015, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacology

  M009, Spring, Graduate School of Medicine, 2
• From Apr. 2017, To Mar. 2018

  Pharmacology

  Fall, Faculty of Medicine
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Pharmacology

  Fall, Faculty of Medicine
• From Apr. 2017, To Mar. 2018

  Laboratory visit

  Spring, Graduate School of Medicine
• From Apr. 2017, To Mar. 2018

  Pharmacology II

  Fall, Graduate School of Medicine
• From Apr. 2017, To Mar. 2018

  Pharmacology I

  Fall, Graduate School of Medicine
• From Apr. 2017, To Mar. 2018

  Pharmacology

  Fall, Graduate School of Medicine
• From Apr. 2019, To Mar. 2020

  Pharmacology II

  Spring, Graduate School of Medicine
• From Apr. 2019, To Mar. 2020

  Pharmacology I

  Spring, Graduate School of Medicine
• From Apr. 2019, To Mar. 2020

  Pharmacology

  Spring, Graduate School of Medicine
• From Apr. 2020, To Mar. 2021

  Cellular & Molecular Mechanisms in Neural Development and Regeneration

  Spring, Graduate School of Biostudies
• From Apr. 2020, To Mar. 2021

  Pharmacology II

  Spring, Graduate School of Medicine
• From Apr. 2020, To Mar. 2021

  Pharmacology I

  Spring, Graduate School of Medicine
• From Apr. 2020, To Mar. 2021

  Pharmacology

  Spring, Graduate School of Medicine
• From Apr. 2021, To Mar. 2022

  Pharmacology

  Spring, Faculty of Medicine
• From Apr. 2021, To Mar. 2022

  Pharmacology Laboratory Class and Tutorial

  Spring, Faculty of Medicine
• From Apr. 2021, To Mar. 2022

  Pharmacology II

  Spring, Graduate School of Medicine
• From Apr. 2021, To Mar. 2022

  Pharmacology I

  Spring, Graduate School of Medicine
• From Apr. 2021, To Mar. 2022

  Pharmacology

  Spring, Graduate School of Medicine

Participation in PhD Defense

• Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

  YAMAWAKI YUKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum

  TAKAHASHI MEGUMU, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Conformational change of RNA‐helicase DHX30 by ALS/FTD‐linked FUS induces mitochondrial dysfunction and cytosolic aggregates

  HIKIAMI RYOTA, Graduate School of Medicine, Chief Examiner

  23 Jan. 2023
• Insulin-Like Growth Factor 1 on the Maintenance of Ribbon Synapses in Mouse Cochlear Explant Cultures

  LI GAO, Graduate School of Medicine, Chief Examiner

  23 May 2022
• Antidepressant response and stress resilience are promoted by CART peptides in GABAergic neurons of the anterior cingulate cortex

  FUNAYAMA YUKI, Graduate School of Medicine, Chief Examiner

  23 May 2022
• Glucose as a Protein-Condensing Cellular Solute

  NODA NAOTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

  NAKATSUKA DAIKI, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022
• Long Time Constant May Endorse Sharp Waves and Spikes Than Sharp Transients in Scalp Electroencephalography: A Comparison of Both After-Slow Among Different Time Constant and High-Frequency Activity Analysis

  SHAMIMA SULTANA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface

  MOHAMMED J.M. SHQIRAT, Graduate School of Medicine, Chief Examiner

  24 Sep. 2021
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy

  INOUE YUTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• MicroRNA profiling in adults with high-functioning autism spectrum disorder

  NAKATA MASATOSHI, Graduate School of Medicine, Chief Examiner

  24 Jan. 2022
• Trait-Based Subtypes of ASD by the Multi-Dimensional Scale for PDD and ADHD (MSPA)

  MIYASAKA HARUKA, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• Effects of a stable concentration of propofol upon interictal high-frequency oscillations in drug-resistant epilepsy

  INADA TAKU, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Hes1 oscillation frequency correlates with activation of neural stem cells

  KAISE TAKASHI, Graduate School of Medicine, Chief Examiner

  26 Jul. 2021
• Lamellipodium tip actin barbed ends serve as a force sensor

  KOSEKI KAZUMA, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment

  OKAMOTO SHINICHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021