Basic Information

Academic Degree

• 医学博士(京都大学)

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901068100773866

• External link

  http://www2.mfour.med.kyoto-u.ac.jp

researchmap URL

• https://researchmap.jp/read0012306

Research

Research Interests

• 分子発生学
• 分子免疫学
• Molecular immunology

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Molecular biology

Papers

• Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators

  Vaibhav Pal Singh; Shuhei Hirose; Misao Takemoto; Asmaa M. A. S. Farrag; Shin-ichi Sato; Tasuku Honjo; Kenji Chamoto; Motonari Uesugi

  Journal of the American Chemical Society, 07 Jun. 2024

  
• GENETIC-HETEROGENEITY IN BLAST CRISIS OF CHRONIC MYELOCYTIC-LEUKEMIA

  T IKEDA; K KITA; H MIWA; K KAWAKAMI; H ANAZAWA; T OHNO; T NOSAKA; M HATANAKA; T HONJO; S SHIRAKAWA

  LEUKEMIA RESEARCH, 1990, Peer-reviewed

  
• Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling

  Masato Ogishi; Koji Kitaoka; Kim L. Good-Jacobson; Darawan Rinchai; Baihao Zhang; Jun Wang; Vincent Gies; Geetha Rao; Tina Nguyen; Danielle T. Avery; Taushif Khan; Megan E. Smithmyer; Joseph Mackie; Rui Yang; Andrés Augusto Arias; Takaki Asano; Khoren Ponsin; Matthieu Chaldebas; Peng Zhang; Jessica N. Peel; Jonathan Bohlen; Romain Lévy; Simon J. Pelham; Wei-Te Lei; Ji Eun Han; Iris Fagniez; Maya Chrabieh; Candice Laine; David Langlais; Conor Gruber; Fatima Al Ali; Mahbuba Rahman; Caner Aytekin; Basilin Benson; Matthew J. Dufort; Clara Domingo-Vila; Kunihiko Moriya; Mark Shlomchik; Gulbu Uzel; Paul E. Gray; Daniel Suan; Kahn Preece; Ignatius Chua; Satoshi Okada; Shunsuke Chikuma; Hiroshi Kiyonari; Timothy I. Tree; Dusan Bogunovic; Philippe Gros; Nico Marr; Cate Speake; Richard A. Oram; Vivien Béziat; Jacinta Bustamante; Laurent Abel; Bertrand Boisson; Anne-Sophie Korganow; Cindy S. Ma; Matthew B. Johnson; Kenji Chamoto; Stéphanie Boisson-Dupuis; Tasuku Honjo; Jean-Laurent Casanova; Stuart G. Tangye

  Immunity, Nov. 2024

  
• Administration of interleukin ‐5 or ‐10 activates peritoneal B‐1 cells and induces autoimmune hemolytic anemia in anti‐erythrocyte autoantibody‐transgenic mice

  Sazuku Nisitani; Takeshi Tsubata; Masao Murakami; Tasuku Honjo

  European Journal of Immunology, 1995

  
• Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3

  Hisataka Sabe; Junko Kuno; Antonis Koromllas; Yuji Saito; Tatsuo Kinashi; Masamichi Ueda; Tetsurou Takamatsu; Michinari Hamaguchi; Toshiaki Kawakami; Tasuku Honjo

  International Immunology, Nov. 1991

  
• Biochemical evidence for a third chain of the interleukin-2 receptor

  Y. Saito; H. Tada; H. Sabe; T. Honjo

  Journal of Biological Chemistry, 1991

  
• Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells

  Yasushi Hamaguchi; Yuzuru Kanakura; Jun Fujita; Shun-Ichi Takeda; Toru Nakano; Seiichiro Tarui; Tasuku Honjo; Yukihiko Kitamura

  Journal of Experimental Medicine, 01 Jan. 1987

  
• Molecular basis for two different affinity states of the interleukin 2 receptor: Affinity conversion model

  S. Kondo; A. Shimizu; Y. Saito; M. Kinoshita; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1986

  
• Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene

  Helena Islam; Maki Kobayashi; Tasuku Honjo

  International Immunology, 01 Aug. 2019

  
• PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8 + T cells and facilitates anti–PD-1 therapy

  Partha S. Chowdhury; Kenji Chamoto; Alok Kumar; Tasuku Honjo

  Cancer Immunology Research, 01 Nov. 2018

  
• Ape1 is dispensable for s-region cleavage but required for its repair in class switch recombination

  Jianliang Xu; Afzal Husain; Wenjun Hu; Tasuku Honjo; Maki Kobayashi

  Proceedings of the National Academy of Sciences of the United States of America, 02 Dec. 2014

  
• BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL

  Santosh K Gothwal; Ahmed M Refaat; Mikiyo Nakata; Andre Stanlie; Tasuku Honjo; Nasim A Begum

  Nucleic Acids Research, 03 Apr. 2024

  
• REARRANGEMENTS OF IMMUNOGLOBULIN GENES DURING DIFFERENTIATION AND EVOLUTION

  T HONJO; S NAKAI; Y NISHIDA; T KATAOKA; Y YAMAWAKIKATAOKA; N TAKAHASHI; M OBATA; A SHIMIZU; Y YAOITA; T NIKAIDO; N ISHIDA

  IMMUNOLOGICAL REVIEWS, 1981

  
• 人生100年時代の「老い」を考える スペルミジンは脂肪酸酸化を直接活性化し、老化個体における抗腫瘍免疫を回復させる

  本庶 佑; Al Habsi Muna; 茶本 健司; 松本 健; 野村 紀通; Wu Yibo; Zhang Baihao; 仲島 由佳; 園村 和弘; Menzies Rosemary; 杉浦 悠毅; 野村 弥生; 松田 文彦; 岩田 想; 小椋 利彦; Fagarasan Sidonia

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

  K Shibahara; M Asano; Y Ishida; T Aoki; T Koike; T Honjo

  GENE, Dec. 1995, Peer-reviewed

  
• Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation

  M. Aida; N. Hamad; A. Stanlie; N. A. Begum; T. Honjo

  Proceedings of the National Academy of Sciences, Apr. 2013

  
• Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells

  N. Watanabe; T. Nomura; T. Takai; T. Chiba; T. Honjo; T. Tsubata

  Scandinavian Journal of Immunology, 1998, Peer-reviewed

  
• MOLECULAR MECHANISMS FOR B-LYMPHOCYTE SELECTION - INDUCTION AND REGULATION OF ANTIGEN-RECEPTOR-MEDIATED APOPTOSIS OF MATURE B-CELLS IN NORMAL MICE AND THEIR DEFECT IN AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; S NISITANI; T HONJO

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, Aug. 1994

  
• Spermidine – an old molecule with a new age-defying immune function

  Kenji Chamoto; Baihao Zhang; Masaki Tajima; Tasuku Honjo; Sidonia Fagarasan

  Trends in Cell Biology, Sep. 2023

  
• Notch-RBP-Jシグナルは大脳皮質層形成を調節する(Notch-RBP-J signaling regulates cortical laminar fates)

  谷垣 健二; 山本 典生; 辻 正幸; 本庶 佑

  神経化学, Aug. 2004

  
• ROLE OF IL-2-R INDUCING FACTOR (ADF) IN THE CONSTITUTIVE IL-2-R GENE-EXPRESSION IN ADULT T-CELL LEUKEMIA (ATL)

  J YODOI; T NIKAIDO; H SABE; K TESHIGAWARA; M OKADA; Y TAGAYA; N ISHIDA; A SHIMIZU; M MAEDA; T UCHIYAMA; T HONJO

  FEDERATION PROCEEDINGS, 1985

  
• T-CELL REPLACING FACTOR INTERLEUKIN-5 INDUCES NOT ONLY B-CELL GROWTH AND DIFFERENTIATION, BUT ALSO INCREASED EXPRESSION OF INTERLEUKIN-2 RECEPTOR ON ACTIVATED B-CELLS

  N HARADA; M MATSUMOTO; N KOYAMA; A SHIMIZU; T HONJO; A TOMINAGA; K TAKATSU

  IMMUNOLOGY LETTERS, Jul. 1987, Peer-reviewed

  
• PRODUCTION AND CHARACTERIZATION OF THE EXTRACYTOPLASMIC PORTION OF THE HUMAN INTERLEUKIN-2 RECEPTOR

  A SHIMIZU; N KONDO; S KONDO; J HAMURO; T HONJO

  MOLECULAR BIOLOGY & MEDICINE, Dec. 1986, Peer-reviewed

  
• STRUCTURE AND FUNCTION OF THE INTERLEUKIN-2 RECEPTOR - AFFINITY CONVERSION MODEL

  A SHIMIZU; S KONDO; H SABE; N ISHIDA; T HONJO

  IMMUNOLOGICAL REVIEWS, 1986, Peer-reviewed

  
• Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

  Maki Kobayashi; Hiroyuki Wakaguri; Masakazu Shimizu; Koichiro Higasa; Fumihiko Matsuda; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 24 Apr. 2023

  
• Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family

  Daisuke Hoshiyama; Hiroshi Suga; Naoyuki Iwabe; Mitsumasa Koyanagi; Naruo Nikoh; Kei-Ichi Kuma; Fumihiko Matsuda; Tasuku Honjo; Takashi Miyata

  Journal of Molecular Evolution, 1998, Peer-reviewed

  
• Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease - Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs

  T Akamizu; F Matsuda; J Okuda; H Li; H Kanda; T Watanabe; T Honjo; T Mori

  JOURNAL OF IMMUNOLOGY, Oct. 1996, Peer-reviewed

  
• HETEROGENEITY AND DIVERSITY OF IGM AND IGG LUPUS ANTICOAGULANTS IN AN INDIVIDUAL WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

  N NAKAMURA; C AZUMA; T AKAMIZU; H SUGAWA; F MATSUDA; N MITSUDA; T HONJO; T MORI; K YAMAJI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1994, Peer-reviewed

  
• VARIABLE REGIONS OF IG HEAVY-CHAIN GENES ENCODING ANTITHYROTROPIN RECEPTOR ANTIBODIES OF PATIENTS WITH GRAVES-DISEASE

  EK SHIN; T AKAMIZU; F MATSUDA; H SUGAWA; J FUJIKURA; T MORI; T HONJO

  JOURNAL OF IMMUNOLOGY, Feb. 1994, Peer-reviewed

  
• POLYMORPHISM OF THE HUMAN-IMMUNOGLOBULIN VARIABLE REGION SEGMENT V1-4.1

  EK SHIN; F MATSUDA; S OZAKI; S KUMAGAI; O OLERUP; H STROM; MELCHERS, I; T HONJO

  IMMUNOGENETICS, Jun. 1993, Peer-reviewed

  
• HOMINOID EVOLUTION BASED ON THE STRUCTURES OF IMMUNOGLOBULIN EPSILON-GENES AND ALPHA-GENES

  S UEDA; Y WATANABE; H HAYASHIDA; T MIYATA; F MATSUDA; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986, Peer-reviewed

  
• HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

  Ahmed M. Refaat; Mikiyo Nakata; Afzal Husain; Hidetaka Kosako; Tasuku Honjo; Nasim A. Begum

  Cell Reports, Mar. 2023, Peer-reviewed

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• IL-2 CAN SUPPORT GROWTH OF CD8(+) T-CELLS BUT NOT CD4(+) T-CELLS OF HUMAN IL-2 RECEPTOR BETA-CHAIN TRANSGENIC MICE

  M ASANO; Y ISHIDA; H SABE; M KONDO; K SUGAMURA; T HONJO

  JOURNAL OF IMMUNOLOGY, Dec. 1994, Peer-reviewed

  
• INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH

  Y ISHIDA; Y AGATA; K SHIBAHARA; T HONJO

  EMBO JOURNAL, Nov. 1992, Peer-reviewed

  
• EXPRESSION OF MURINE IL-2-RECEPTOR BETA-CHAIN ON THYMIC AND SPLENIC LYMPHOCYTE SUBPOPULATIONS AS REVEALED BY THE IL-2-INDUCED PROLIFERATIVE RESPONSE IN HUMAN IL-2-RECEPTOR ALPHA-CHAIN TRANSGENIC MICE

  M HATTORI; H OKAZAKI; Y ISHIDA; M ONUMA; S KANO; T HONJO; N MINATO

  JOURNAL OF IMMUNOLOGY, May 1990, Peer-reviewed

  
• EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; M HATTORI; N MINATO; M KAWAICHI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1989, Peer-reviewed

  
• Effects of the deregulated expression of human interleukin-2 in transgenic mice

  Yasumasa Ishida; Masashi Kawaichi; Tasuku Honjo; Osamu Taguchi; Kayo Inaba; Nagahiro Minato; Miyuki Nishi

  International Immunology, 1989, Peer-reviewed

  
• IMMUNE DYSFUNCTIONS AND ACTIVATION OF NATURAL-KILLER-CELLS IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989, Peer-reviewed

  
• IMMUNE DYSFUNCTIONS AND ACTIVATION OF NATURAL-KILLER-CELLS IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989, Peer-reviewed

  
• Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.

  Nasim A Begum; Farazul Haque; Andre Stanlie; Afzal Husain; Samiran Mondal; Mikiyo Nakata; Takako Taniguchi; Hisaaki Taniguchi; Tasuku Honjo

  The EMBO journal, 15 Jun. 2021

  
• Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells

  Afzal Husain; Nasim Begum; Maki Kobayashi; Tasuku Honjo

  BIO-PROTOCOL, 2020

  
• Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

  Azza Al Ismail; Afzal Husain; Maki Kobayashi; Tasuku Honjo; Nasim A Begum

  International Immunology, 30 Dec. 2017

  
• Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

  Samiran Mondal; Nasim A. Begum; Wenjun Hu; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 15 Mar. 2016

  
• Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

  Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo

  Proceedings of the National Academy of Sciences, Apr. 2015

  
• Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining

  Andre Stanlie; Ashraf S. Yousif; Hideo Akiyama; Tasuku Honjo; Nasim A. Begum

  Molecular Cell, Jul. 2014

  
• The Non-Canonical function of UNG in AID induced Antibody Gene Diversification

  Yousif Ashraf; Begum Nasim; Honjo Tasuku

  Frontiers in Immunology, 2013

  
• Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Nisitani; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 2002, Peer-reviewed

  
• Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

  H Han; K Tanigaki; N Yamamoto; K Kuroda; M Yoshimoto; T Nakahata; K Ikuta; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jun. 2002, Peer-reviewed

  
• Induction of germline transcription in the human TCRγ locus by STAT51

  H. C. Lee; S. K. Ye; T. Honjo; K. Ikuta

  Journal of Immunology, 01 Jul. 2001, Peer-reviewed

  
• Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice

  T Sakiyama; K Ikuta; S Nisitani; K Takatsu; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jun. 1999, Peer-reviewed

  
• STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN PD-1 GENE (PDCD1)

  T SHINOHARA; M TANIWAKI; Y ISHIDA; M KAWAICHI; T HONJO

  GENOMICS, Oct. 1994, Peer-reviewed

  
• Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice.

  Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; N. Minato; M. Kawaichi; T. Honjo

  Princess Takamatsu symposia, 1988, Peer-reviewed

  
• EVIDENCE FOR THE INTERLEUKIN-2 DEPENDENT EXPANSION OF LEUKEMIC-CELLS IN ADULT T-CELL LEUKEMIA

  M MAEDA; N ARIMA; Y DAITOKU; M KASHIHARA; H OKAMOTO; T UCHIYAMA; K SHIRONO; M MATSUOKA; T HATTORI; K TAKATSUKI; K IKUTA; A SHIMIZU; T HONJO; J YODOI

  BLOOD, Nov. 1987

  
• HUMAN-LYMPHOCYTE FC RECEPTOR FOR IGE - SEQUENCE HOMOLOGY OF ITS CLONED CDNA WITH ANIMAL LECTINS

  K IKUTA; M TAKAMI; CW KIM; T HONJO; T MIYOSHI; Y TAGAYA; T KAWABE; J YODOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1987, Peer-reviewed

  
• Durable tumor remission in patients with platinum-resistant ovarian cancer receiving nivolumab.

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Yuko Hosoe; Satoshi Morita; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  JOURNAL OF CLINICAL ONCOLOGY, May 2015, Peer-reviewed

  
• Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer.

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Masashi Kanai; Yukiko Mori; Shigemi Matsumoto; Toshinori Murayama; Shunsuke Chikuma; Satoshi Morita; Masayuki Yokode; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  JOURNAL OF CLINICAL ONCOLOGY, May 2014, Peer-reviewed

  
• Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice

  T Nomura; H Han; MC Howard; H Yagita; H Yakura; T Honjo; T Tsubata

  INTERNATIONAL IMMUNOLOGY, Jun. 1996

  
• Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

  Yasutoshi Agata; Akemi Kawasaki; Hiroyuki Nishimura; Yasumasa Ishida; Takeshi Tsubata; Hideo Yagita; Tasuku Honjo

  International Immunology, 1996

  
• RECOMBINATION OF EXOGENOUS INTERLEUKIN-2 RECEPTOR GENE FLANKED BY IMMUNOGLOBULIN RECOMBINATION SIGNAL SEQUENCES IN A PRE-B CELL-LINE AND TRANSGENIC MICE

  M KAWAICHI; C OKA; R REEVES; M KINOSHITA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1991, Peer-reviewed

  
• A LARGER NUMBER OF L-CHAINS (TAC) ENHANCE THE ASSOCIATION RATE OF INTERLEUKIN-2 TO THE HIGH-AFFINITY SITE OF THE INTERLEUKIN-2 RECEPTOR

  Y SAITO; H SABE; N SUZUKI; S KONDO; T OGURA; A SHIMIZU; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 1988, Peer-reviewed

  
• MOLECULAR MECHANISM FOR THE FORMATION OF THE HIGH-AFFINITY COMPLEX OF INTERLEUKIN-2 AND ITS RECEPTOR

  T OGURA; M KONISHI; N SUZUKI; S KONDO; H SABE; T HONJO

  MOLECULAR BIOLOGY & MEDICINE, Apr. 1988, Peer-reviewed

  
• Expression of interleukin 2 receptors on interleukin 3-dependent cell lines.

  Shigeo Koyasu; Junji Yodoi; Toshio Nikaido; Yutaka Tagaya; Yoshihisa Taniguchi; Tasuku Honjo; Ichiro Yahara

  Journal of Immunology, 01 Feb. 1986, Peer-reviewed

  
• Soluble programmed cell death ligand 1 predicts prognosis for gastric cancer patients treated with nivolumab: Blood-based biomarker analysis for the DELIVER trial

  Hisato Kawakami; Yu Sunakawa; Eisuke Inoue; Ryo Matoba; Kenta Noda; Toshiyuki Sato; Chihiro Suminaka; Mami Yamaki; Yasuhiro Sakamoto; Ryohei Kawabata; Atsushi Ishiguro; Yusuke Akamaru; Yosuke Kito; Hiroshi Yabusaki; Jin Matsuyama; Masazumi Takahashi; Akitaka Makiyama; Hidetoshi Hayashi; Kenji Chamoto; Tasuku Honjo; Kazuhiko Nakagawa; Wataru Ichikawa; Masashi Fujii

  European Journal of Cancer, May 2023, Peer-reviewed

  
• Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

  Kenji Chamoto; Tomonori Yaguchi; Masaki Tajima; Tasuku Honjo

  Nature Reviews Immunology, 25 Apr. 2023

  
• Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer

  Kentaro Tanaka; Kenji Chamoto; Sho Saeki; Ryusuke Hatae; Yuki Ikematsu; Kazuko Sakai; Nobuhisa Ando; Kazuhiro Sonomura; Shinsuke Kojima; Masanori Taketsuna; Young Hak Kim; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Tomoko Hirano; Fumihiko Matsuda; Toyohiro Hirai; Kazuto Nishio; Takuro Sakagami; Masanori Fukushima; Yoichi Nakanishi; Tasuku Honjo; Isamu Okamoto

  Science Translational Medicine, 14 Dec. 2022

  
• Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

  Shingo Matsushima; Masahiko Ajiro; Kei Iida; Kenji Chamoto; Tasuku Honjo; Masatoshi Hagiwara

  Science Translational Medicine, 30 Nov. 2022

  
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Al-Habsi; Kenji Chamoto; Ken Matsumoto; Norimichi Nomura; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Aprilia Maharani; Yuka Nakajima; Yibo Wu; Yayoi Nomura; Rosemary Menzies; Masaki Tajima; Koji Kitaoka; Yasuharu Haku; Sara Delghandi; Keiko Yurimoto; Fumihiko Matsuda; So Iwata; Toshihiko Ogura; Sidonia Fagarasan; Tasuku Honjo

  Science, 28 Oct. 2022

  
• B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

  Baihao Zhang; Alexis Vogelzang; Michio Miyajima; Yuki Sugiura; Yibo Wu; Kenji Chamoto; Rei Nakano; Ryusuke Hatae; Rosemary J. Menzies; Kazuhiro Sonomura; Nozomi Hojo; Taisaku Ogawa; Wakana Kobayashi; Yumi Tsutsui; Sachiko Yamamoto; Mikako Maruya; Seiko Narushima; Keiichiro Suzuki; Hiroshi Sugiya; Kosaku Murakami; Motomu Hashimoto; Hideki Ueno; Takashi Kobayashi; Katsuhiro Ito; Tomoko Hirano; Katsuyuki Shiroguchi; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan

  Nature, 18 Nov. 2021

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• Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

  Masato Ogishi; Rui Yang; Caner Aytekin; David Langlais; Mathieu Bourgey; Taushif Khan; Fatima Al Ali; Mahbuba Rahman; Ottavia M. Delmonte; Maya Chrabieh; Peng Zhang; Conor Gruber; Simon J. Pelham; András N. Spaan; Jérémie Rosain; Wei-Te Lei; Scott Drutman; Matthew D. Hellmann; Margaret K. Callahan; Matthew Adamow; Phillip Wong; Jedd D. Wolchok; Geetha Rao; Cindy S. Ma; Yuka Nakajima; Tomonori Yaguchi; Kenji Chamoto; Samuel C. Williams; Jean-Francois Emile; Flore Rozenberg; Michael S. Glickman; Franck Rapaport; Gaspard Kerner; Garrett Allington; Ilhan Tezcan; Deniz Cagdas; Ferda O. Hosnut; Figen Dogu; Aydan Ikinciogullari; V. Koneti Rao; Leena Kainulainen; Vivien Béziat; Jacinta Bustamante; Silvia Vilarinho; Richard P. Lifton; Bertrand Boisson; Laurent Abel; Dusan Bogunovic; Nico Marr; Luigi D. Notarangelo; Stuart G. Tangye; Tasuku Honjo; Philippe Gros; Stéphanie Boisson-Dupuis; Jean-Laurent Casanova

  Nature Medicine, Sep. 2021

  
• Critical role of the CD44 ^low CD62L ^low CD8 ⁺ T cell subset in restoring antitumor immunity in aged mice

  Yuka Nakajima; Kenji Chamoto; Takuma Oura; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 08 Jun. 2021

  
• Circulation of gut-preactivated naïve CD8+T cells enhances antitumor immunity in B cell-defective mice

  Maryam Akrami; Rosemary Menzies; Kenji Chamoto; Michio Miyajima; Ryuji Suzuki; Hiroyuki Sato; Akiko Nishii; Michio Tomura; Sidonia Fagarasan; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 22 Sep. 2020

  
• SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

  Afzal Husain; Jiangliang Xu; Hodaka Fujii; Mikiyo Nakata; Maki Kobayashi; Ji‐Yang Wang; Jan Rehwinkel; Tasuku Honjo; Nasim A Begum

  The EMBO Journal, 08 Jun. 2020, Peer-reviewed

  
• RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

  Ziwei Yin; Maki Kobayashi; Wenjun Hu; Koichi Higashi; Nasim A. Begum; Ken Kurokawa; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 26 May 2020

  
• Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

  Alok Kumar; Kenji Chamoto; Partha S Chowdhury; Tasuku Honjo

  eLife, 03 Mar. 2020, Peer-reviewed

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• Current issues and perspectives in PD-1 blockade cancer immunotherapy

  Chamoto, K.; Hatae, R.; Honjo, T.

  International Journal of Clinical Oncology, 2020, Peer-reviewed

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• Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma

  Megumi Goto; Kenji Chamoto; Keiko Higuchi; Saya Yamashita; Kenta Noda; Takuya Iino; Masahiro Miura; Toshinari Yamasaki; Osamu Ogawa; Makoto Sonobe; Hiroshi Date; Junzo Hamanishi; Masaki Mandai; Yoshimasa Tanaka; Shunsuke Chikuma; Ryusuke Hatae; Manabu Muto; Sachiko Minamiguchi; Nagahiro Minato; Tasuku Honjo

  Scientific Reports, 01 Dec. 2019

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• 免疫療法の新規バイオマーカー 進行NSCLCにおける可溶性免疫チェックポイント因子の役割(Novel biomarkers for immunotherapies The role of soluble immune-checkpoint factors in advanced NSCLC)

  Hayashi Hidetoshi; 茶本 健司; 冨樫 庸介; 中川 和彦; 本庶 佑

  肺癌, Nov. 2019

  
• Novel biomarkers for immunotherapies The role of soluble immune-checkpoint factors in advanced NSCLC(和訳中)

  Hayashi Hidetoshi; 茶本 健司; 冨樫 庸介; 中川 和彦; 本庶 佑

  肺癌, Nov. 2019, Peer-reviewed

  
• Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553-563.

  Muramatsu M; Kinoshita K; Fagarasan S; Yamada S; Shinkai Y; Honjo T

  Journal of immunology (Baltimore, Md. : 1950), Nov. 2018, Peer-reviewed

  
• Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy

  P. S. Chowdhury; K. Chamoto; T. Honjo

  Journal of Internal Medicine, 01 Feb. 2018, Peer-reviewed

  
• Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

  Michio Miyajima; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Matteo M. Guerrini; Yumi Tsutsui; Mikako Maruya; Alexis Vogelzang; Kenji Chamoto; Kurara Honda; Takatoshi Hikida; Satomi Ito; Hongyan Qin; Rikako Sanuki; Keiichiro Suzuki; Takahisa Furukawa; Yasushi Ishihama; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan

  NATURE IMMUNOLOGY, Dec. 2017, Peer-reviewed

  
• Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes

  Gabrielle McDonald; Carlos O. Medina; Monika Pilichowska; John F. Kearney; Reiko Shinkura; Erik Selsing; Henry H. Wortis; Tasuku Honjo; Thereza Imanishi-Kari

  Frontiers in Immunology, 13 Sep. 2017, Peer-reviewed

  
• Role of PD-1 in Immunity and Diseases

  Kenji Chamoto; Muna Al-Habsi; Tasuku Honjo

  EMERGING CONCEPTS TARGETING IMMUNE CHECKPOINTS IN CANCER AND AUTOIMMUNITY, 2017, Peer-reviewed

  
• Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

  Kenji Chamoto; Partha S. Chowdhury; Alok Kumar; Kazuhiro Sonomura; Fumihiko Matsuda; Sidonia Fagarasan; Tasuku Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed

  
• Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.

  Zhang Baihao; Chikuma Shunsuke; Hori Shohei; Fagarasan Sidonia; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 07 Jul. 2016

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• Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

  Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo

  Nature Communications, 04 Feb. 2016

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• Safety and antitumor activity of Anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Toshinori Murayama; Masashi Kanai; Yukiko Mori; Shigemi Matsumoto; Shunsuke Chikuma; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Yuko Hosoe; Satoshi Morita; Masayuki Yokode; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  Journal of Clinical Oncology, 01 Dec. 2015

  
• Molecular Mechanisms of AID Function

  Nasim A. Begum; Hitoshi Nagaoka; Maki Kobayashi; Tasuku Honjo

  Molecular Biology of B Cells, 2015

  
• Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

  Tung Nguyen; Jianliang Xu; Shunsuke Chikuma; Hiroshi Hiai; Kazuo Kinoshita; Kyoji Moriya; Kazuhiko Koike; Gian Paolo Marcuzzi; Herbert Pfister; Tasuku Honjo; Maki Kobayashi

  INTERNATIONAL IMMUNOLOGY, Jul. 2014, Peer-reviewed

  
• Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten

  Akikazu Murakami; Hayato Moriyama; Mina Osako-Kabasawa; Kanako Endo; Miyuki Nishimura; Keiko Udaka; Masamichi Muramatsu; Tasuku Honjo; Takachika Azuma; Takeyuki Shimizu

  INTERNATIONAL IMMUNOLOGY, Apr. 2014

  
• Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten.

  Akikazu Murakami; Hayato Moriyama; Mina Osako-Kabasawa; Kanako Endo; Miyuki Nishimura; Keiko Udaka; Masamichi Muramatsu; Tasuku Honjo; Takachika Azuma; Takeyuki Shimizu

  International immunology, Apr. 2014

  
• C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.

  Sabouri Somayeh; Kobayashi Maki; Begum Nasim A; Xu Jianliang; Hirota Kouji; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 11 Feb. 2014

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• A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

  Taku Okazaki; Shunsuke Chikuma; Yoshiko Iwai; Sidonia Fagarasan; Tasuku Honjo

  Nature Immunology, Dec. 2013, Peer-reviewed

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• RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.

  Guoxin Liang; Kouichi Kitamura; Zhe Wang; Guangyan Liu; Sajeda Chowdhury; Weixin Fu; Miki Koura; Kousho Wakae; Tasuku Honjo; Masamichi Muramatsu

  Proceedings of the National Academy of Sciences of the United States of America, 05 Feb. 2013

  
• In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression

  Le Thi Huong; Le Thi Huong; Maki Kobayashi; Mikiyo Nakata; Go Shioi; Hitoshi Miyachi; Tasuku Honjo; Hitoshi Nagaoka

  PLoS ONE, 2013, Peer-reviewed

  
• The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation

  Nasim A. Begum; Andre Stanlie; Mikiyo Nakata; Hideo Akiyama; Tasuku Honjo

  Journal of Biological Chemistry, 21 Sep. 2012, Peer-reviewed

  
• Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability

  Nasim A. Begum; Tasuku Honjo

  Biochemistry, 03 Jul. 2012, Peer-reviewed

  
• TRIM28 prevents autoinflammatory T cell development in vivo

  Shunsuke Chikuma; Naomasa Suita; Il-Mi Okazaki; Shiro Shibayama; Tasuku Honjo

  Nature Immunology, Jun. 2012, Peer-reviewed

  
• The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination

  Andre Stanlie; Nasim A. Begum; Hideo Akiyama; Tasuku Honjo

  PLoS Genetics, Apr. 2012, Peer-reviewed

  
• Cartilage-specific RBPjκ-dependent and -independent notch signals regulate cartilage and bone development

  Anat Kohn; Yufeng Dong; Anthony J. Mirando; Alana M. Jesse; Tasuku Honjo; Michael J. Zuscik; Regis J. O'Keefe; Matthew J. Hilton

  Development, Mar. 2012, Peer-reviewed

  
• Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

  Lucia Kato; Nasim A. Begum; A. Maxwell Burroughs; Tomomitsu Doi; Jun Kawai; Carsten O. Daub; Takahisa Kawaguchi; Fumihiko Matsuda; Yoshihide Hayashizaki; Tasuku Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2012, Peer-reviewed

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• The AID dilemma: infection, or cancer?

  HonjoTasuku; Kobayashi Maki; Begum Nasim; Kotani Ai; Sabouri Somayeh; Nagaoka Hitoshi

  Advances in cancer research, 2012, Peer-reviewed

  
• Activation-Induced Cytidine Deaminase Expression in CD4 T Cellsis Associated with a Unique IL-10-Producing Subset that Increases with Age.

  Qin, H; Suzuki, K; Nakata, M; Chikuma, S; Izumi, N; Thi Huong, L; Maruya, M; Fagarasan, S; Busslinger, M; Honjo, T; Nagaoka, H

  PLoS One, 28 Dec. 2011, Peer-reviewed

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• Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

  Maki Kobayashi; Zahra Sabouri; Somayeh Sabouri; Yoko Kitawaki; Yves Pommier; Takaya Abe; Hiroshi Kiyonari; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 29 Nov. 2011, Peer-reviewed

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• Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

  Okazaki IM(Kyoto; Natsume Tohru(National; Institute of; Advanced Industrial Science; Technology),Iemura Shun-Ichiro(National; Institute of; Advanced Industrial Science; Technology; Honjo Tasuku; Kyoto University; Okawa Katsuya(Kyowa; Hakko Kirin Co; Kobayashi Maki; Kyoto university; Yoshikawa Kiyotsugu(Dana-Farber Cancer Institute; Kawamoto Shimpei(RIKEN Research Center; Nagaoka Hitoshi(Gifu University; Shinkura Reiko(Nagahama; Institute of Bioscience; Technology; Kitawaki Yoko; yo; Taniguchi Hisaaki(University of Tokushim

  Proc Natl Acad Sci U S A, 10 May 2011, Peer-reviewed

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• Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1

  Fredy R.S. Gutierrez; Flávia S. Mariano; Carlo J.F. Oliveira; Wander R. Pavanelli; Paulo M.M. Guedes; Grace K. Silva; Ana P. Campanelli; Cristiane M. Milanezi; Miyuki Azuma; Tasuku Honjo; Mauro M. Teixeira; Julio C.S. Aliberti; João S. Silva

  Infection and Immunity, May 2011, Peer-reviewed

  
• Type I interferon promotes PD-1 transcription and limits the duration of T cell-mediated immunity

  Shunsuke Chikuma; Seigo Terawaki; Shiro Shibayama; Tamon Hayashi; Takao Yoshida; Taku Okazaki; Tasuku Honjo

  JOURNAL OF IMMUNOLOGY, Apr. 2011, Peer-reviewed

  
• IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity

  Seigo Terawaki; Shunsuke Chikuma; Shiro Shibayama; Tamon Hayashi; Takao Yoshida; Taku Okazaki; Tasuku Honjo

  Journal of Immunology, 01 Mar. 2011, Peer-reviewed

  
• Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

  Min Wei; Reiko Shinkura; Yasuko Doi; Mikako Maruya; Sidonia Fagarasan; Tasuku Honjo

  Nature Immunology, Mar. 2011, Peer-reviewed

  
• Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis

  Grégory Peignon; Aurélie Durand; Wulfran Cacheux; Olivier Ayrault; Benoît Terris; Pierre Laurent-Puig; Noah F. Shroyer; Isabelle Van Seuningen; Tasuku Honjo; Christine Perret; Béatrice Romagnolo

  Gut, Feb. 2011, Peer-reviewed

  
• PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

  Taku Okazaki; Il-Mi Okazaki; Jian Wang; Daisuke Sugiura; Fumio Nakaki; Taku Yoshida; Yu Kato; Sidonia Fagarasan; Masamichi Muramatsu; Tomoo Eto; Kyoji Hioki; Tasuku Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 2011, Peer-reviewed

  
• Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

  Andre Stanlie; Masatoshi Aida; Masamichi Muramatsu; Tasuku Honjo; Nasim A. Begum

  Proceedings of the National Academy of Sciences of the United States of America, 21 Dec. 2010, Peer-reviewed

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• Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

  Robin Jeannet; Jérôme Mastio; Alejandra Macias-Garcia; Attila Oravecz; Todd Ashworth; Anne-Solen Geimer Le Lay; Bernard Jost; Stéphanie Le Gras; Jacques Ghysdael; Thomas Gridley; Tasuku Honjo; Freddy Radtke; Jon C. Aster; Susan Chan; Philippe Kastner

  Blood, 16 Dec. 2010, Peer-reviewed

  
• X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells

  Kate L. Jones; Michael Roche; Michael P. Gantier; Nasim A. Begum; Tasuku Honjo; Salvatore Caradonna; Bryan R. G. Williams; Johnson Mak

  Journal of Biological Chemistry, 11 Jun. 2010, Peer-reviewed

  
• RBPj kappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

  Yufeng Dong; Alana M. Jesse; Anat Kohn; Lea M. Gunnell; Tasuku Honjo; Michael J. Zuscik; Regis J. O'Keefe; Matthew J. Hilton

  DEVELOPMENT, May 2010, Peer-reviewed

  
• PD-1 deficiency results in the development of fatal myocarditis in MRL mice

  Jian Wang; Il-Mi Okazaki; Taku Yoshida; Shunsuke Chikuma; Yu Kato; Fumio Nakaki; Hiroshi Hiai; Tasuku Honjo; Taku Okazaki

  International Immunology, 21 Apr. 2010, Peer-reviewed

  
• Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

  Ryosuke Hino; Kenji Kabashima; Yu Kato; Hiroaki Yagi; Motonobu Nakamura; Tasuku Honjo; Taku Okazaki; Yoshiki Tokura

  Cancer, 01 Apr. 2010, Peer-reviewed

  
• Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity.

  Nagaoka Hitoshi; Tran Thinh Huy; Kobayashi Maki; Aida Masatoshi; Honjo Tasuku

  International immunology, Apr. 2010, Peer-reviewed

  
• Anti-programmed cell death 1 antibody reduces CD4⁺PD-1 ⁺ T cells and relieves the lupus-like nephritis of NZB/W F1 Mice

  Shimpei Kasagi; Seiji Kawano; Taku Okazaki; Tasuku Honjo; Akio Morinobu; Saori Hatachi; Kenichiro Shimatani; Yoshimasa Tanaka; Nagahiro Minato; Shunichi Kumagai

  Journal of Immunology, 01 Mar. 2010

  
• B cell-specific and stimulation-responsive enhancers derepress Aicda byovercoming the effects of silencers.

  Tran Thinh Huy; Nakata Mikiyo; Suzuki Keiichiro; Begum Nasim A; Shinkura Reiko; Fagarasan Sidonia; Honjo Tasuku; Nagaoka Hitoshi

  Nature immunology, Feb. 2010, Peer-reviewed

  
• AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

  Kobayashi M; Aida M; Nagaoka H; Begum NA; Kitawaki Y; Nakata M; Stanlie A; Doi T; Kato L; Okazaki IM; Shinkura R; Muramatsu M; Kinoshita K; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, Dec. 2009, Peer-reviewed

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• AID-induced decrease in topoisomerase 1 induces DNA structural alterationand DNA cleavage for class switch recombination.

  Kobayashi Maki; Aida Masatoshi; Nagaoka Hitoshi; Begum Nasim A; Kitawaki Yoko; Nakata Mikiyo; Stanlie Andre; Doi Tomomitsu; Kato Lucia; Okazaki Il-mi; Shinkura Reiko; Muramatsu Masamichi; Kinoshita Kazuo; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, Dec. 2009, Peer-reviewed

  
• RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

  Motoaki Fujimoto; Yasushi Takagi; Kazue Muraki; Kazuhiko Nozaki; Norio Yamamoto; Masayuki Tsuji; Nobuo Hashimoto; Tasuku Honjo; Kenji Tanigaki

  Developmental Biology, 15 Aug. 2009, Peer-reviewed

  
• Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

  Zahra Sabouri; Il-Mi Okazaki; Reiko Shinkura; Nasim Begum; Hitoshi Nagaoka; Daisuke Tsuchimoto; Yusaku Nakabeppu; Tasuku Honjo

  International immunology, Aug. 2009, Peer-reviewed

  
• Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

  Sabouri Zahra; Okazaki Il-Mi; Shinkura Reiko; Begum Nasim; Nagaoka Hitoshi; Tsuchimoto Daisuke; Nakabeppu Yusaku; Honjo Tasuku

  International immunology, Aug. 2009, Peer-reviewed

  
• PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo

  Shunsuke Chikuma; Seigo Terawaki; Tamon Hayashi; Ryusuke Nabeshima; Takao Yoshida; Shiro Shibayama; Taku Okazaki; Tasuku Honjo

  Journal of Immunology, 01 Jun. 2009, Peer-reviewed

  
• Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

  Marie Carlén; Konstantinos Meletis; Christian Göritz; Vladimer Darsalia; Emma Evergren; Kenji Tanigaki; Mario Amendola; Fanie Barnabé-Heider; Maggie S. Y. Yeung; Luigi Naldini; Tasuku Honjo; Zaal Kokaia; Oleg Shupliakov; Robert M. Cassidy; Olle Lindvall; Jonas Frisén

  Nature Neuroscience, Mar. 2009, Peer-reviewed

  
• Preferential Generation of Follicular B Helper T Cells from Foxp3(+) T Cells in Gut Peyer's Patches

  Masayuki Tsuji; Noriko Komatsu; Shimpei Kawamoto; Keiichiro Suzuki; Osami Kanagawa; Tasuku Honjo; Shohei Hori; Sidonia Fagarasan

  SCIENCE, Mar. 2009, Peer-reviewed

  
• Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis

  Yukio Sekiguchi; Motoki Ichikawa; Masaya Takamoto; Hiroyoshi Ota; Chang-Sung Koh; Masamichi Muramatsu; Tasuku Honjo; Kazunaga Agematsu

  Immunology Letters, 21 Feb. 2009, Peer-reviewed

  
• Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.

  Nonaka T; Doi T; Toyoshima T; Muramatsu M; Honjo T; Kinoshita K

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Peer-reviewed

  
• The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

  Doi T; Kato L; Ito S; Shinkura R; Wei M; Nagaoka H; Wang J; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Peer-reviewed

  
• The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

  Doi Tomomitsu; Kato Lucia; Ito Satomi; Shinkura Reiko; Wei Min; Nagaoka Hitoshi; Wang Jishu; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Peer-reviewed

  
• Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination

  Nasim A. Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Peer-reviewed

  
• A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

  A. Takai; T. Toyoshima; M. Uemura; Y. Kitawaki; H. Marusawa; H. Hiai; S. Yamada; I.M. Okazaki; T. Honjo; T. Chiba; K. Kinoshita

  Oncogene, 29 Jan. 2009, Peer-reviewed

  
• T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions

  Sunao Sugita; Yoshihiko Usui; Shintaro Horie; Yuri Futagami; Hiroyuki Aburatani; Taku Okazaki; Tasuku Honjo; Masaru Takeuchi; Manabu Mochizuki

  Investigative Ophthalmology and Visual Science, 2009, Peer-reviewed

  
• Identification of QTLs that modify peripheral neuropathy in NOD. H2b - Pdcd1-/- mice

  Fang Jiang; Taku Yoshida; Fumio Nakaki; Seigo Terawaki; Shunsuke Chikuma; Yu Kato; Il-Mi Okazaki; Tasuku Honjo; Taku Okazaki

  International Immunology, 2009, Peer-reviewed

  
• Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

  Toshiyuki Morisawa; Hiroyuki Marusawa; Yoshibide Ueda; Akio Iwai; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba

  INTERNATIONAL JOURNAL OF CANCER, Dec. 2008, Peer-reviewed

  
• 発癌過程における遺伝子異常の生成へのActivation-induced cytidine deaminase(AID)の関与

  遠藤 容子; 丸澤 宏之; 木下 和生; 本庶 佑; 千葉 勉

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants

  Velizar Shivarov; Reiko Shinkura; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 14 Oct. 2008, Peer-reviewed

  
• Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling

  Masahiro Kido; Norihiko Watanabe; Taku Okazaki; Takuji Akamatsu; Junya Tanaka; Kazuyuki Saga; Akiyoshi Nishio; Tasuku Honjo; Tsutomu Chiba

  Gastroenterology, Oct. 2008, Peer-reviewed

  
• Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

  Fabienne Haspot; Thomas Fehr; Carrie Gibbons; Guiling Zhao; Timothy Hogan; Tasuku Honjo; Gordon J. Freeman; Megan Sykes

  Blood, 01 Sep. 2008, Peer-reviewed

  
• Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers

  Y. Endo; H. Marusawa; T. Kou; H. Nakase; S. Fujii; T. Fujimori; K. Kinoshita; T. Honjo; T. Chiba

  Gastroenterology, Sep. 2008, Peer-reviewed

  
• A memoir of AID, which engraves antibody memory on DNA

  Tasuku Honjo

  Nature Immunology, Apr. 2008, Peer-reviewed

  
• PD-1 deficiency reveals various tissue-specific autoimmunity by H-2 b and dose-dependent requirement of H-2g7 for diabetes in NOD mice

  Taku Yoshida; Fang Jiang; Tasuku Honjo; Taku Okazaki

  Proceedings of the National Academy of Sciences of the United States of America, 04 Mar. 2008, Peer-reviewed

  
• The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome

  Kathy A. Green; Taku Okazaki; Tasuku Honjo; W. James Cook; William R. Green

  Journal of Virology, Mar. 2008, Peer-reviewed

  
• The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

  David Yin Wei Lin; Yoshimasa Tanaka; Masashi Iwasaki; Apostolos G. Gittis; Hua Poo Su; Bunzo Mikami; Taku Okazaki; Tasuku Honjo; Nagahiro Minato; David N. Garboczi

  Proceedings of the National Academy of Sciences of the United States of America, 26 Feb. 2008

  
• A mouse model for inflammation-associated carcinogenesis in digestive organs; the AID-transgenic mouse

  Toshiyuki Morisawa; Hiroyuki Marusawa; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008

  
• Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

  Orbicia Riccio; Marielle E. van Gijn; April C. Bezdek; Luca Pellegrinet; Johan H. van Es; Ursula Zimber-Strobl; Lothar J. Strobl; Tasuku Honjo; Hans Clevers; Freddy Radtke

  EMBO Reports, 2008, Peer-reviewed

  
• AID is required for germinal center-derived lymphomagenesis

  Laura Pasqualucci; Govind Bhagat; Mila Jankovic; Mara Compagno; Paula Smith; Masamichi Muramatsu; Tasuku Honjo; Herbert C. Morse III; Michel C. Nussenzweig; Riccardo Dalla-Favera

  Nature Genetics, Jan. 2008, Peer-reviewed

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase (Journal of Biological Chemistry (2006) 281, (19115-19123))

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  Journal of Biological Chemistry, Jan. 2008, Peer-reviewed

  
• The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling

  Okiru Komine; Mai Nagaoka; Kei Watase; David H. Gutmann; Kenji Tanigaki; Tasuku Honjo; Freddy Radtke; Toshiki Saito; Shigeru Chiba; Kohichi Tanaka

  Developmental Biology, 01 Nov. 2007, Peer-reviewed

  
• AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

  Alexander L. Kovalchuk; Wendy Dubois; Elizabeth Mushinski; Nicole E. McNeil; Carsten Hirt; Chen-Feng Qi; Zhaoyang Li; Siegfried Janz; Tasuku Honjo; Masamichi Muramatsu; Thomas Ried; Timothy Behrens; Michael Potter

  JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2007, Peer-reviewed

  
• Multiple roles of Notch signaling in cochlear development.

  Takebayashi S; Yamamoto N; Yabe D; Fukuda H; Kojima K; Ito J; Honjo T

  Developmental biology, 01 Jul. 2007, Peer-reviewed

  
• Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: Possible application to enhance T cell function

  Seigo Terawaki; Yoshimasa Tanaka; Tomokazu Nagakura; Tamon Hayashi; Shiro Shibayama; Kaori Muroi; Taku Okazaki; Bunzo Mikami; David N. Garboczi; Tasuku Honjo; Nagahiro Minato

  International Immunology, 01 Jul. 2007

  
• Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.

  Yabe D; Fukuda H; Aoki M; Yamada S; Takebayashi S; Shinkura R; Yamamoto N; Honjo T

  Genesis (New York, N.Y. : 2000), May 2007, Peer-reviewed

  
• Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer

  Junzo Hamanishi; Masaki Mandai; Masashi Iwasaki; Taku Okazaki; Yoshimasa Tanaka; Ken Yamaguchi; Toshihiro Higuchi; Haruhiko Yagi; Kenji Takakura; Nagahiro Minato; Tasuku Honjo; Shingo Fujii

  Proceedings of the National Academy of Sciences of the United States of America, 27 Feb. 2007

  
• AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells

  Kaori Kumazaki; Boaz Tirosh; René Maehr; Marianne Boes; Tasuku Honjo; Hidde L. Ploegh

  Journal of Immunology, 15 Feb. 2007, Peer-reviewed

  
• Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

  Tsuji M; Shinkura R; Kuroda K; Yabe D; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, 03 Jan. 2007, Peer-reviewed

  
• Regulation of AID function in vivo

  Reiko Shinkura; Il-Mi Okazaki; Taro Muto; Nasim A. Begum; Tasuku Honjo

  Advances in Experimental Medicine and Biology, 2007, Peer-reviewed

  
• Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling

  Y. Endo; H. Marusawa; K. Kinoshita; T. Morisawa; T. Sakurai; I.-M. Okazaki; K. Watashi; K. Shimotohno; T. Honjo; T. Chiba

  Oncogene, 2007, Peer-reviewed

  
• Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

  Y. Matsumoto; H. Marusawa; K. Kinoshita; Y. Endo; T. Kou; T. Morisawa; T. Azuma; I.-M. Okazaki; T. Honjo; T. Chiba

  Nature Medicine, 2007, Peer-reviewed

  
• Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination

  Nasim A. Begum; Nakako Izumi; Momoko Nishikori; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo

  Journal of Biological Chemistry, Jan. 2007, Peer-reviewed

  
• Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

  Ai Kotani; Naoki Kakazu; Tatsuaki Tsuruyama; Il Mi Okazaki; Masamichi Muramatsu; Kazuo Kinoshita; Hitoshi Nagaoka; Daisuke Yabe; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Jan. 2007, Peer-reviewed

  
• The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

  Shinya Tanaka; Jun Tsukada; Wataru Suzuki; Katsuhiko Hayashi; Kenji Tanigaki; Masayuki Tsuji; Hiromasa Inoue; Tasuku Honjo; Masato Kubo

  Immunity, Jun. 2006, Peer-reviewed

  
• The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

  Krista D. Buono; Gertraud W. Robinson; Cyril Martin; Shaolin Shi; Pamela Stanley; Kenji Tanigaki; Tasuku Honjo; Lothar Hennighausen

  Developmental Biology, 15 May 2006, Peer-reviewed

  
• The 20th IUBMB International Congress in Kyoto

  Koichi Ikuta; Ryoichiro Kageyama; Tasuku Honjo

  IUBMB Life, May 2006, Peer-reviewed

  
• Negative regulation of activation-induced cytidine deaminase in B cells

  Taro Muto; Taro Muto; Il Mi Okazaki; Shuichi Yamada; Yoshimasa Tanaka; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2006, Peer-reviewed

  
• Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.

  Yamamoto N; Tanigaki K; Tsuji M; Yabe D; Ito J; Honjo T

  Journal of molecular medicine (Berlin, Germany), Jan. 2006, Peer-reviewed

  
• Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas

  J. Fujikura; K. Hosoda; H. Iwakura; T. Tomita; M. Noguchi; H. Masuzaki; K. Tanigaki; D. Yabe; T. Honjo; K. Nakao

  Cell Metabolism, 2006, Peer-reviewed

  
• Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID

  Koshou Wakae; Brad G. Magor; Holly Saunders; Hitoshi Nagaoka; Akemi Kawamura; Kazuo Kinoshita; Tasuku Honjo; Masamichi Muramatsu

  International Immunology, Jan. 2006, Peer-reviewed

  
• Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b(-/-)Pdcd1(-/-) mice

  T Okazaki; Y Otaka; J Wang; H Hiai; T Takai; JV Ravetch; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2005, Peer-reviewed

  
• Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome

  Masaya Kobayashi; KAWANO, Seiji; Saori Hatachi; Chiyo Kurimoto; Taku Okazaki; Yoshiko Iwai; Tasuku Honjo; Yoshimasa Tanaka; Nagahiro Minato; KOMORI; Takahide; MAEDA,Sakan; KUMAGAI, Syunichi

  The Journal Of Rheumatology, Nov. 2005

  
• Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila

  Toshiaki Kikuchi; Sita Andarini; Hong Xin; Kazunori Gomi; Yutaka Tokue; Yasuo Saijo; Tasuku Honjo; Akira Watanabe; Toshihiro Nukiwa

  Infection and Immunity, Sep. 2005, Peer-reviewed

  
• Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes

  Jian Wang; Taku Yoshida; Fumio Nakaki; Hiroshi Hiai; Taku Okazaki; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 16 Aug. 2005, Peer-reviewed

  
• AID to overcome the limitations of genomic information

  Tasuku Honjo; Hitoshi Nagaoka; Reiko Shinkura; Masamichi Muramatsu

  Nature Immunology, Jul. 2005, Peer-reviewed

  
• Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

  Hong Xin; Toshiaki Kikuchi; Sita Andarini; Shinya Ohkouchi; Takuji Suzuki; Toshihiro Nukiwa; Huqun; Koichi Hagiwara; Tasuku Honjo; Yasuo Saijo

  European Journal of Immunology, May 2005, Peer-reviewed

  
• PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

  Yoshiko Iwai; Seigo Terawaki; Tasuku Honjo

  International Immunology, Feb. 2005, Peer-reviewed

  
• Two distinctive pathways for recruitment of naive and primed IgM(+) B cells to the gut lamina propria

  K Suzuki; B Meek; Y Doi; T Honjo; S Fagarasan

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2005, Peer-reviewed

  
• Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells.

  Kishi Y; Takahashi J; Koyanagi M; Morizane A; Okamoto Y; Horiguchi S; Tashiro K; Honjo T; Fujii S; Hashimoto N

  Journal of neuroscience research, Feb. 2005, Peer-reviewed

  
• DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase

  Hitoshi Nagaoka; Satomi Ito; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2005, Peer-reviewed

  
• Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

  Hans Christian Probst; Kathy McCoy; Taku Okazaki; Tasuku Honjo; Maries Van Den Broek

  Nature Immunology, 2005, Peer-reviewed

  
• AIDによるクラススイッチと体細胞突然変異の制御機構

  新蔵 礼子; 伊藤 聡美; Begum Nasim; 長岡 仁; 村松 正道; 木下 和生; 土方 博子; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

  Luke T. Krebs; John R. Shutter; Kenji Tanigaki; Tasuku Honjo; Kevin L. Stark; Thomas Gridley

  Genes and Development, 15 Oct. 2004, Peer-reviewed

  
• Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.

  Michishita M; Ikeda T; Nakashiba T; Ogawa M; Tashiro K; Honjo T; Doi K; Itohara S; Endo S

  Brain research. Developmental brain research, Oct. 2004, Peer-reviewed

  
• B1b lymphocytes confer T cell-independent long-lasting immunity

  Kishore R. Alugupalli; John M. Leong; Robert T. Woodland; Masamichi Muramatsu; Tasuku Honjo; Rachel M. Gerstein

  Immunity, Sep. 2004, Peer-reviewed

  
• Production of autoantibodies and autoimmune diseases in PD-1 knock-out mice

  OKAZAKI Taku; OTAKA Yumi; WANG Jian; HONJO Tasuku

  Nihon Rinsho Men'eki Gakkai Sokai Shorokushu, 31 Aug. 2004

  
• AID is required for c-myc/IgH chromosome translocations in vivo

  Almudena R. Ramiro; Mila Jankovic; Thomas Eisenreich; Simone Difilippantonio; Selina Chen-Kiang; Masamichi Muramatsu; Tasuku Honjo; André Nussenzweig; Michel C. Nussenzweig

  Cell, 20 Aug. 2004, Peer-reviewed

  
• De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

  Nasim A. Begum; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Aug. 2004, Peer-reviewed

  
• PD‐1と自己免疫疾患

  岡崎拓; 本庶佑

  最新医学, 10 Jul. 2004

  
• Separate domains of AID are required for somatic hypermutation and class-switch recombination

  Reiko Shinkura; Satomi Ito; Nasim A. Begum; Hitoshi Nagaoka; Masamichi Muramatsu; Kazuo Kinoshita; Yishimasa Sakakibara; Hiroko Hijikata; Tasuku Honjo

  Nature Immunology, Jul. 2004, Peer-reviewed

  
• Regulation of IgA synthesis at mucosal surfaces

  S Fagarasan; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, Jun. 2004, Peer-reviewed

  
• AID: How does it aid antibody diversity?

  T Honjo; M Muramatsu; S Fagarasan

  IMMUNITY, Jun. 2004, Peer-reviewed

  
• Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

  Derk Amsen; J. Magarian Blander; Gap Ryol Lee; Kenji Tanigaki; Tasuku Honjo; Richard A. Flavell

  Cell, 14 May 2004, Peer-reviewed

  
• Regulation of alpha beta/gamma delta, T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

  K Tanigaki; M Tsuji; N Yamamoto; H Han; J Tsukada; H Inoue; M Kubo; T Honjo

  IMMUNITY, May 2004, Peer-reviewed

  
• Neural precursor cells derived from human embryonic brain retain regional specificity.

  Horiguchi S; Takahashi J; Kishi Y; Morizane A; Okamoto Y; Koyanagi M; Tsuji M; Tashiro K; Honjo T; Fujii S; Hashimoto N

  Journal of neuroscience research, Mar. 2004, Peer-reviewed

  
• Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

  Keiichiro Suzuki; Bob Meek; Yasuko Doi; Masamichi Muramatsu; Tsutomu Chiba; Tasuku Honjo; Sidonia Fagarasan

  Proceedings of the National Academy of Sciences of the United States of America, 17 Feb. 2004, Peer-reviewed

  
• PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

  Christian Blank; Ian Brown; Amy C. Peterson; Mike Spiotto; Yoshiko Iwai; Tasuku Honjo; Thomas F. Gajewski

  Cancer Research, 01 Feb. 2004, Peer-reviewed

  
• Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

  Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2004, Peer-reviewed

  
• Unmutated immunoglobulin M can protect mice from death by influenza virus infection

  Yuichi Harada; Masamichi Muramatsu; Toshikatsu Shibata; Tasuku Honjo; Kazufumi Shimizu; Eiko Matsumura; Kazumichi Kuroda

  International Congress Series, 2004, Peer-reviewed

  
• OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst

  A.T. Nishida; K. Kobuke; K. Kojima; J. Ito; T. Honjo; K. Tashiro

  Developmental Dynamics, 2004, Peer-reviewed

  
• Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

  Taku Okazaki; Yoshimasa Tanaka; Ryosuke Nishio; Tamotsu Mitsuiye; Akira Mizoguchi; Jian Wang; Masayoshi Ishida; Hiroshi Hiai; Akira Matsumori; Nagahiro Minato; Tasuku Honjo

  Nature Medicine, 01 Dec. 2003

  
• AID蛋白質量とクラススイッチ組み換え及び体細胞高頻度突然変異効率の解析

  伊藤 聡美; 長岡 仁; 木下 和生; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• B細胞における体細胞高頻度突然変異はApobec1では誘導されない

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

  T. Eto; K. Kinoshita; K. Yoshikawa; M. Muramatsu; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 28 Oct. 2003, Peer-reviewed

  
• Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.

  Toda H; Tsuji M; Nakano I; Kobuke K; Hayashi T; Kasahara H; Takahashi J; Mizoguchi A; Houtani T; Sugimoto T; Hashimoto N; Palmer TD; Honjo T; Tashiro K

  The Journal of biological chemistry, Sep. 2003, Peer-reviewed

  
• AID mutant analyses indicate requirement for class-switch-specific cofactors

  Van Thanh Ta; Hitoshi Nagaoka; Nadia Catalan; Anne Durandy; Alain Fischer; Kohsuke Imai; Kohsuke Imai; Shigeaki Nonoyama; Shigeaki Nonoyama; Junko Tashiro; Masaya Ikegawa; Satomi Ito; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo

  Nature Immunology, Sep. 2003, Peer-reviewed

  
• PD-1 inhibits antiviral immunity at the effector phase in the liver

  Yoshiko Iwai; Seigo Terawaki; Masaya Ikegawa; Taku Okazaki; Tasuku Honjo

  Journal of Experimental Medicine, 07 Jul. 2003

  
• A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain.

  Michishita M; Ikeda T; Nakashiba T; Ogawa M; Tashiro K; Honjo T; Doi K; Itohara S; Endo S

  Biochemical and biophysical research communications, Jul. 2003, Peer-reviewed

  
• Unmutated immunoglobulin M can protect mice from death by influenza virus infection

  Yuichi Harada; Masamichi Muramatsu; Toshikatsu Shibata; Tasuku Honjo; Kazumichi Kuroda

  Journal of Experimental Medicine, 16 Jun. 2003, Peer-reviewed

  
• Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.

  Mito Kanatsu-Shinohara; Shinya Toyokuni; Takeshi Morimoto; Shigeyuki Matsui; Tasuku Honjo; Takashi Shinohara

  Biology of reproduction, May 2003, Peer-reviewed

  
• Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase

  Yi Zhu; Shigeaki Nonoyama; Tomohiro Morio; Masamichi Muramatsu; Tasuku Honjo; Shuki Mizutani

  Journal of Medical and Dental Sciences, Mar. 2003

  
• De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

  T Doi; K Kinoshita; M Ikegawa; M Muramatsu; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2003, Peer-reviewed

  
• Molecular Mechanism of Class Switch Recombination

  Janet Stavnezer; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo

  Molecular Biology of B Cells, 18 Feb. 2003, Peer-reviewed

  
• Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

  K Kuroda; H Han; S Tani; K Tanigaki; T Tun; T Furukawa; Y Taniguchi; H Kurooka; Y Hamada; S Toyokuni; T Honjo

  IMMUNITY, Feb. 2003, Peer-reviewed

  
• Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.

  Yamamoto N; Tanigaki K; Han H; Hiai H; Honjo T

  Current biology : CB, Feb. 2003, Peer-reviewed

  
• AID Links Class Switching and Somatic Hypermutation

  Honjo Tasuku; Okazaki Ilmi; Yoshikawa Kiyotsugu; Muramatsu Masamichi; Kinoshita Kazuo

  Japanese Journal of Allergology, 2003

  
• Intestinal IgA synthesis: Regulation of front-line body defences

  S Fagarasan; T Honjo

  NATURE REVIEWS IMMUNOLOGY, Jan. 2003, Peer-reviewed

  
• New regulatory co-receptors: inducible co-stimulator and PD-1

  T Okazaki; Y Iwai; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, Dec. 2002, Peer-reviewed

  
• Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

  Sidonia Fagarasan; Masamichi Muramatsu; Keiichiro Suzuki; Hitoshi Nagaoka; Hiroshi Hiai; Tasuku Honjo

  Science, 15 Nov. 2002, Peer-reviewed

  
• Microanatomical localization of PD-1 in human tonsils

  Y Iwaia; T Okazaki; H Nishimura; A Kawasaki; H Yagita; T Honjo

  IMMUNOLOGY LETTERS, Oct. 2002, Peer-reviewed

  
• Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

  Masayoshi Ishida; Yoshiko Iwai; Yoshimasa Tanaka; Taku Okazaki; Gordon J. Freeman; Nagahiro Minato; Tasuku Honjo

  Immunology Letters, Oct. 2002, Peer-reviewed

  
• クラススイッチ刺激によるSmu領域へのAID依存性の点変異

  長岡 仁; 村松 正道; 伊藤 聡美; 木下 和生; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• Bリンパ球における体細胞高頻度突然変異はクラススイッチ誘導刺激でも誘導される

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 清水 章; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• AIDは,線維芽細胞中で活発に転写される遺伝子に対して,過剰変異を誘導する

  吉川 清次; 岡崎 一美; 江藤 知憲; 木下 和生; 村松 正道; 長岡 仁; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• AID-estrogen receptor融合タンパク質AID-ERによる抗体多様化機構の解析

  木下 和生; 土井 知光; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

  Y Iwai; M Ishida; Y Tanaka; T Okazaki; T Honjo; N Minato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2002, Peer-reviewed

  
• AIDは,免疫グロブリン遺伝子H鎖Smu領域に点変異を誘導する

  長岡 仁; 村松 正道; 山村 奈美子; 木下 和生; 本庶 佑

  生化学, Aug. 2002

  
• Bリンパ球における体細胞高頻度突然変異はクラススイッチ誘導刺激でも誘導される

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 清水 章; 本庶 佑

  生化学, Aug. 2002

  
• AID-estrogen receptor融合タンパク質AID-ERによる抗体多様化機構の解析

  木下 和生; 土井 知光; 村松 正道; 本庶 佑

  生化学, Aug. 2002

  
• DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation

  L Bross; M Muramatsu; K Kinoshita; T Honjo; H Jacobs

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2002, Peer-reviewed

  
• Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.

  Tanigaki K; Han H; Yamamoto N; Tashiro K; Ikegawa M; Kuroda K; Suzuki A; Nakano T; Honjo T

  Nature immunology, May 2002, Peer-reviewed

  
• Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice.

  Kanatsu-Shinohara M; Ogura A; Ikegawa M; Inoue K; Ogonuki N; Tashiro K; Toyokuni S; Honjo T; Shinohara T

  Proceedings of the National Academy of Sciences of the United States of America, Feb. 2002, Peer-reviewed

  
• Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Sμ region: Implication of AID involvement in a common step of class switch recombination and somatic hypermutation

  Hitoshi Nagaoka; Masamichi Muramatsu; Namiko Yamamura; Kazuo Kinoshita; Tasuku Honjo; Tasuku Honjo

  Journal of Experimental Medicine, Feb. 2002, Peer-reviewed

  
• Molecular mechanism of class switch recombination: Linkage with somatic hypermutation

  T Honjo; K Kinoshita; M Muramatsu

  ANNUAL REVIEW OF IMMUNOLOGY, 2002, Peer-reviewed

  
• Fibulin-5/DANCE is essential for elastogenesis in vivo.

  Nakamura T; Lozano PR; Ikeda Y; Iwanaga Y; Hinek A; Minamisawa S; Cheng CF; Kobuke K; Dalton N; Takada Y; Tashiro K; Ross J Jr; Honjo T; Chien KR

  Nature, Jan. 2002, Peer-reviewed

  
• AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

  Simone Petersen; Rafael Casellas; Bernardo Reina-San-Martin; Hua Tang Chen; Michael J. Difilippantonio; Patrick C. Wilson; Leif Hanitsch; Arkady Celeste; Masamichi Muramatsu; Duane R. Pilch; Christophe Redon; Thomas Ried; William M. Bonner; Tasuku Honjo; Michel C. Nussenzweig; André Nussenzweig

  Nature, 06 Dec. 2001, Peer-reviewed

  
• 外来AID強制発現によるAID欠損B細胞のクラススイッチ能の回復

  村松 正道; 木下 和生; 鄭 一美; シドニア・ファガラサン; 本庶 佑

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 新たなクラススイッチ組換えの指標 環状DNAに由来する転写産物の検出

  木下 和生; 張谷 素子; シドニア・ファガラサン; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

  T Okazaki; A Maeda; H Nishimura; T Kurosaki; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2001, Peer-reviewed

  
• Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

  Chen X; Kinoshita K; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, Nov. 2001, Peer-reviewed

  
• A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

  K Kinoshita; M Harigai; S Fagarasan; M Muramatsu; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2001, Peer-reviewed

  
• ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes,is up-regulated after vascular injury.

  Kobuke, K; Furukawa, Y; Sugai, M; Tanigaki, K; Ohashi, N; Matsumori, A; Sasayama, S; Honjo, T; Tashiro, K

  J. Biol. Chem., Sep. 2001, Peer-reviewed

  
• クラススイッチ組換え活性はAID強制発現により線維芽細胞に移入できる

  鄭 一美; 木下 和生; 村松 正道; 本庶 佑

  生化学, Aug. 2001

  
• 新たなクラススイッチ組換えの指標 環状DNAに由来する転写産物の検出

  木下 和生; 張谷 素子; Fagarasan Sidonia; 村松 正道; 本庶 佑

  生化学, Aug. 2001

  
• レトロウイルスベクターを用いたAID欠損B細胞のスイッチ能の回復

  村松 正道; 木下 和生; 吉川 清次; 榊原 祥公; 鄭 一美; Van Ta; 本庶 佑

  生化学, Aug. 2001

  
• Quantitative regulation of class switch recombination by switch region transcription.

  Lee CG; Kinoshita K; Arudchandran A; Cerritelli SM; Crouch RJ; Honjo T

  The Journal of experimental medicine, Aug. 2001, Peer-reviewed

  
• Linking class-switch recombination with somatic hypermutation.

  Kinoshita K; Honjo T

  Nature reviews. Molecular cell biology, Jul. 2001, Peer-reviewed

  
• Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

  K Hattori; B Heissig; K Tashiro; T Honjo; M Tateno; JH Shieh; NR Hackett; MS Quitoriano; RG Crystal; S Rafii; MAS Moore

  BLOOD, Jun. 2001, Peer-reviewed

  
• PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

  H Nishimura; T Honjo

  TRENDS IN IMMUNOLOGY, May 2001, Peer-reviewed

  
• Elevated Plasma Stromal Cell-Derived Factor 1 Protein Level in the Progression of HIV Type 1 Infection/AIDS.

  Ikegawa, M; Yuan, J; Matsumoto, K; Herrmann, S; Iwamoto, I; Nakamura, T; Matsushita, S; Kimura, T; Honjo, T; Tashiro, K

  AIDS Research and Human Retroviruses, May 2001, Peer-reviewed

  
• Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination

  Y Agata; T Katakai; SK Ye; M Sugai; H Gonda; T Honjo; K Ikuta; A Shimizu

  JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2001, Peer-reviewed

  
• The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription

  S Tani; H Kurooka; T Aoki; N Hashimoto; T Honjo

  NUCLEIC ACIDS RESEARCH, Mar. 2001, Peer-reviewed

  
• PD-L2 is a second ligand for PD-1 and inhibits T cell activation

  Yvette Latchman; Clive R. Wood; Tatyana Chernova; Divya Chaudhary; Madhuri Borde; Irene Chernova; Yoshiko Iwai; Andrew J. Long; Julia A. Brown; Raquel Nunes; Edward A. Greenfield; Karen Bourque; Vassiliki A. Boussiotis; Laura L. Carter; Beatriz M. Carreno; Nelly Malenkovich; Hiroyuki Nishimura; Taku Okazaki; Tasuku Honjo; Arlene H. Sharpe; Gordon J. Freeman

  Nature Immunology, Mar. 2001, Peer-reviewed

  
• The regulation of PD-1/PD-L1 pathway and autoimmune diseases

  T Okazaki; Y Iwai; H Nishimura; T Honjo

  ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS, 2001, Peer-reviewed

  
• The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation

  S.-K. Ye; Y. Agata; H.-C. Lee; H. Kurooka; T. Kitamura; A. Shimizu; T. Honjo; K. Ikuta

  Immunity, 2001, Peer-reviewed

  
• In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

  S. Fagarasan; K. Kinoshita; M. Muramatsu; K. Ikuta; T. Honjo

  Nature, 2001, Peer-reviewed

  
• Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate

  Tanigaki, K; Nogaki, F; Takahashi, J; Tashiro, K; Kurooka, H; Honjo, T

  Neuron, Jan. 2001, Peer-reviewed

  
• Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Fagarasan; S Yazumi; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2000, Peer-reviewed

  
• アカゲザルにおける低分子化合物(ONO-4007)投与によるSHIV増殖抑制効果

  大倉 定之; 山下 満左裕; 池川 雅哉; 伊吹 謙太郎; 柴山 史朗; 築山 貴美; 松尾 政芳; 田丸 敬次郎; 田代 啓; 本庶 佑

  日本エイズ学会誌, Nov. 2000

  
• ヒトActivation-Induced cytidine Deaminase(AID)の単離,発現パターン,染色体位置の同定

  武藤 太郎; 村松 正道; 谷脇 雅史; 木下 和生; Revy Patrick; Durandy Anne; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

  GJ Freeman; AJ Long; Y Iwai; K Bourque; T Chernova; H Nishimura; LJ Fitz; N Malenkovich; T Okazaki; MC Byrne; HF Horton; L Fouser; L Carter; Ling, V; MR Bowman; BM Carreno; M Collins; CR Wood; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 2000, Peer-reviewed

  
• Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.

  Nakashiba T; Ikeda T; Nishimura S; Tashiro K; Honjo T; Culotti JG; Itohara S

  The Journal of neuroscience : the official journal of the Society for Neuroscience, Sep. 2000, Peer-reviewed

  
• Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA, (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA

  T Kamata; F Nogaki; S Fagarasan; T Sakiyama; N Kobayashi; S Miyawaki; K Ikuta; E Muso; H Yoshida; S Sasayama; T Honjo

  JOURNAL OF IMMUNOLOGY, Aug. 2000, Peer-reviewed

  
• クラススイッチ組み換えと体細胞超変異にはRNA校正cytidine deaminaseファミリーの一つである活性化誘導cytidine deaminase(AID)を必要とする

  村松 正道; 木下 和生; Fagarasan Sidonia; 山田 秀一; 真貝 洋一; 本庶 佑

  生化学, Aug. 2000

  
• 免疫グロブリンクラススイッチ組み換えはS配列の高次構造を認識する

  田代 純子; 木下 和生; 李 充基; 陳 小川; 本庶 佑

  生化学, Aug. 2000

  
• ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mouse.

  Kato, K; Morrison, A. M; Toru, N; Tashiro, K; Honjo, T

  Blood, Jul. 2000, Peer-reviewed

  
• Functional interaction between the mouse Notch1 intracellular region and histone acetyltransferases PCAF and GCN5

  K Kurooka; T Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2000, Peer-reviewed

  
• Alymphoplasia (aly)-type Nuclear Factor B-inducing Kinase (NIK) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-associated Lymphatic Tissue System.

  Fagarasan, S; Shinkura, R; Kamata, T; Nogaki, F; Ikuta, K; Tashiro, K; Cyster, G. J; Honjo, T

  J. Exp. Med., May 2000, Peer-reviewed

  
• Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice

  H Nishimura; T Honjo; N Minato

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2000, Peer-reviewed

  
• Mechanism of B1 cell differentiation and migration in GALT

  S. Fagarasan; R. Shinkura; T. Kamata; F. Nogaki; K. Ikuta; T. Honjo

  Current Topics in Microbiology and Immunology, 2000, Peer-reviewed

  
• Molecular definition of the autosomal recessive form of the hyper-IgM syndrome

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; A Gennery; H Kayserili; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  IX MEETING OF THE EUROPEAN SOCIETY FOR IMMUNODEFICIENCIES, 2000, Peer-reviewed

  
• Stormal-derived factor-1 (SDF1) induces TNF-alpha mediated progenitor cell apoptosis of CD34+cells derived from chronic myeloid leukemia (CML).

  Heissig B; Hattori K; Dias S; Tashiro K; Honjo T; Rafii S; Crystal RG; Moore MAS

  BLOOD, 15 Nov. 1999, Peer-reviewed

  
• 免疫グロブリンクラススイッチ組換えに必要なS配列の解析

  田代 純子; 木下 和生; 李 充基; 陳 小川; 吉川 清次; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 1999

  
• 免疫グロブリンクラススイッチ傷害細胞株の解析

  木下 和生; 吉川 清次; 李 充基; 田代 純子; 村松 正道; 陳 小川; 本庶 佑

  生化学, Aug. 1999

  
• 日本人正常集団におけるHIV-1耐性遺伝子多型の頻度

  池川 雅哉; 田代 啓; 矢部 大介; 本庶 佑

  生化学, Aug. 1999

  
• Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment

  N Watanabe; S Nisitani; K Ikuta; M Suzuki; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 1999, Peer-reviewed

  
• DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.

  Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon NL; Schaub R; Matsumori A; Sasayama S; Chien KR; Honjo T

  The Journal of Biological Chemistry, Aug. 1999, Peer-reviewed

  
• Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

  M. Muramatsu; V.S. Sankaranand; S. Anant; M. Sugai; K. Kinoshita; N.O. Davidson; T. Honjo

  Journal of Biological Chemistry, 25 Jun. 1999, Peer-reviewed

  
• Isoform Specific Expression of the SDR-1 Protein, α and β in Subregions of Adult Rodent Brain

  Lopez, N.D; Kinoshita, A; Taniwaki, M; Tada, H; Shirozu, M; Nakano, T; Tashiro, K; Honjo, T

  Biomed. Res., Jun. 1999

  
• Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.

  Kanazawa N; Nakamura T; Tashiro K; Muramatsu M; Morita K; Yoneda K; Inaba K; Imamura S; Honjo T

  European Journal of Immunology, Jun. 1999, Peer-reviewed

  
• Delta-induced notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

  K Kuroda; S Tani; K Tamura; S Minoguchi; H Kurooka; T Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1999, Peer-reviewed

  
• Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L

  Shoichi Tani; Masafumi Taniwaki; Yoshihito Taniguchi; Shigeru Minoguchi; Kazuki Kuroda; Hua Han; Tomokazu Aoki; Shin-Ichi Miyatake; Nobuo Hashimoto; Tasuku Honjo

  Journal of Human Genetics, 1999, Peer-reviewed

  
• Mechanism of myogenic differentiation suppression by Notch and RBP-J

  H Kurooka; H Kato; Y Taniguchi; S Minoguchi; T Sakai; K Tamura; T Honjo

  NEURAL DEVELOPMENT-BOOK, 1999, Peer-reviewed

  
• The signal sequence trap method.

  Tashiro K; Nakamura T; Honjo T

  Methods in Enzymology, 1999, Peer-reviewed

  
• Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region

  H Kurooka; K Kuroda; T Honjo

  NUCLEIC ACIDS RESEARCH, Dec. 1998, Peer-reviewed

  
• Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability.

  Nakamura T; Yabe D; Kanazawa N; Tashiro K; Sasayama S; Honjo T

  Genomics, Nov. 1998, Peer-reviewed

  
• 免疫グロブリンクラススイッチに伴って発現誘導される新規遺伝子のクローニング

  村松 正道; 木下 和生; 本庶 佑

  日本臨床免疫学会会誌, Oct. 1998

  
• 免疫グロブリンクラススイッチ組換えのクラス特異性はS領域により規定されない

  木下 和生; 田代 純子; 李 充基; 本庶 佑

  日本臨床免疫学会会誌, Oct. 1998

  
• Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses

  H Nishimura; N Minato; T Nakano; T Honjo

  INTERNATIONAL IMMUNOLOGY, Oct. 1998, Peer-reviewed

  
• Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.

  Shioda T; Kato H; Ohnishi Y; Tashiro K; Ikegawa M; Nakayama EE; Hu H; Kato A; Sakai Y; Liu H; Honjo T; Nomoto A; Iwamoto A; Morimoto C; Nagai Y

  Proceedings of the National Academy of Sciences of the United States of America, May 1998, Peer-reviewed

  
• Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

  Yabe D; Taniwaki M; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  Genomics, 01 Apr. 1998, Peer-reviewed

  
• Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

  Yabe D; Taniwaki M; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  Genomics, Apr. 1998, Peer-reviewed

  
• Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase

  M Sugai; S Kondo; A Shimizu; T Honjo

  NUCLEIC ACIDS RESEARCH, Feb. 1998, Peer-reviewed

  
• LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein

  Y Taniguchi; T Furukawa; T Tun; H Han; T Honjo

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 1998, Peer-reviewed

  
• Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.

  Yabe D; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  The Journal of Biological Chemistry, Jul. 1997, Peer-reviewed

  
• RBP-L, a transcription factor related to RBP-J kappa

  S Minoguchi; Y Taniguchi; H Kato; T Okazaki; LJ Strobl; U ZimberStrobl; GW Bornkamm; T Honjo

  MOLECULAR AND CELLULAR BIOLOGY, May 1997, Peer-reviewed

  
• Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2

  Michael B. Paumen; Yasumasa Ishida; Hua Han; Masamichi Muramatsu; Yutaka Eguchi; Yoshihide Tsujimoto; Tasuku Honjo

  Biochemical and Biophysical Research Communications, 24 Feb. 1997, Peer-reviewed

  
• Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin

  H Kurooka; K Kato; S Minoguchi; Y Takahashi; J Ikeda; S Habu; N Osawa; AM Buchberg; K Moriwaki; H Shisa; T Honjo

  GENOMICS, Feb. 1997, Peer-reviewed

  
• Structure of the mutant fibrillin-1 gene in the tight skin (TSK) mouse

  Constantin A. Bona; Chihiro Murai; Sophia Casares; Kuppuswamy Kasturi; Hiroyuki Nishimura; Tasuku Honjo; Fumihiko Matsuda

  DNA Research, 1997, Peer-reviewed

  
• Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

  Michael B. Paumen; Yasumasa Ishida; Masamichi Muramatsu; Masaharu Yamamoto; Tasuku Honjo

  Journal of Biological Chemistry, 1997, Peer-reviewed

  
• Signal Sequence Trap: Expression Cloning Method for Secreted Proteins and Type 1 Membrane Proteins.

  Tashiro, K; Nakano, T; Honjo, T

  Methods in Molecular Biology, Jan. 1997, Peer-reviewed

  
• Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.

  Shirozu M; Tada H; Tashiro K; Nakamura T; Lopez ND; Nazarea M; Hamada T; Sato T; Nakano T; Honjo T

  Genomics, Nov. 1996, Peer-reviewed

  
• Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.

  Hamada T; Tashiro K; Tada H; Inazawa J; Shirozu M; Shibahara K; Nakamura T; Martina N; Nakano T; Honjo T

  Gene, Oct. 1996, Peer-reviewed

  
• Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

  R Shinkura; F Matsuda; T Sakiyama; T Tsubata; H Hiai; M Paumen; S Miyawaki; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jul. 1996, Peer-reviewed

  
• Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus

  H Kurooka; JA Segre; Y Hirano; JL Nemhauser; H Nishimura; K Yoneda; ES Lander; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jun. 1996, Peer-reviewed

  
• Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: A spontaneous model for Sjogren's syndrome

  Rieko Tsubata; Takeshi Tsubata; Hiroshi Hiai; Reiko Shinkura; Ryutaro Matsumura; Takayuki Sumida; Shigeki Miyawaki; Hiroshi Ishida; Shunichi Kumagai; Kazuwa Nakao; Tasuku Honjo

  European Journal of Immunology, 1996, Peer-reviewed

  
• Organization of the human immunoglobulin heavy-chain locus

  F Matsuda; T Honjo

  ADVANCES IN IMMUNOLOGY, VOL 62, 1996, Peer-reviewed

  
• Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes

  Hiroyuki Nishimura; Hiroyuki Nishimura; Yasutoshi Agata; Akemi Kawasaki; Masaki Sato; Sadao Imamura; Nagahiro Minato; Hideo Yagita; Toru Nakano; Tasuku Honjo

  International Immunology, 01 Jan. 1996

  
• The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.

  Nakamura T; Tashiro K; Nazarea M; Nakano T; Sasayama S; Honjo T

  Genomics, Nov. 1995, Peer-reviewed

  
• LOSS OF IMMUNOSTAINING OF THE RBP-J(KAPPA) TRANSCRIPTION FACTOR UPON F9 CELL-DIFFERENTIATION INDUCED BY RETINOIC ACID

  T SAKAI; T FURUKAWA; H IWANARI; C OKA; T NAKANO; M KAWAICHI; T HONJO

  JOURNAL OF BIOCHEMISTRY, Sep. 1995, Peer-reviewed

  
• Structure and Chromosomal Localization of the Human Stromal cellderived factor 1(SDF1)Gene.

  Shirozu, M; Nakano, T; Inazawa, J; Tashiro, K; Tada, H; Shinohara, T; Honjo, T

  Genomics, Aug. 1995

  
• Suppressor of Hairless, the Drosophila homologue of RBP-J.KAPPA., transactivates the neurogenic gene E(spl)m8.

  Furukawa Takahisa; Kobayakawa Yoshitaka; Tamura Kumiko; Kimura Ken-ichi; Kawaichi Masashi; Tanimura Teiichi; Honjo Tasuku

  Genes & Genetic Systems, 1995

  
• Genetic characterization of Drosophila RBP-J_κ(Suppressor of Hairless) as a neurogenic gene in adult PNS development

  FURUKAWA Takahisa; KIMURA Kenichi; KOBAYAKAWA Yoshitaka; TAMURA Kumiko; KAWAICHI Masashi; TANIMURA Teiichi; HONJO Tasuku

  Genes & Genetic Systems, 01 Dec. 1994

  
• RECOGNITION SEQUENCE OF A HIGHLY CONSERVED DNA-BINDING PROTEIN RBP-JKAPPA

  T TUN; Y HAMAGUCHI; N MATSUNAMI; T FURUKAWA; T HONJO; M KAWAICHI

  NUCLEIC ACIDS RESEARCH, Mar. 1994

  
• Transforming growth factor-β induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation

  T. Iwasato; Y. Kanari; A. Shimizu; T. Honjo; H. Yamagishi

  Immunology Letters, 1994, Peer-reviewed

  
• DIVERSIFICATION, NOT USE, OF THE IMMUNOGLOBULIN-VH GENE REPERTOIRE IS RESTRICTED IN DIGEORGE-SYNDROME

  RN HAIRE; RD BUELL; RT LITMAN; Y OHTA; SM FU; T HONJO; F MATSUDA; M DELAMORENA; J CARRO; RA GOOD; GW LITMAN

  JOURNAL OF EXPERIMENTAL MEDICINE, Sep. 1993, Peer-reviewed

  
• CLONING OF A HUMAN-IMMUNOGLOBULIN GENE FRAGMENT CONTAINING BOTH V(H)-D AND D-J(H) REARRANGEMENTS - IMPLICATION FOR V(H)-D AS AN INTERMEDIATE TO V(H)-D-J(H) FORMATION

  EK SHIN; F MATSUDA; J FUJIKURA; T AKAMIZU; H SUGAWA; T MORI; T HONJO

  EUROPEAN JOURNAL OF IMMUNOLOGY, Sep. 1993, Peer-reviewed

  
• HUMAN-JK RECOMBINATION SIGNAL BINDING-PROTEIN GENE (IGKJRB) - COMPARISON WITH ITS MOUSE HOMOLOG

  R AMAKAWA; W JING; K OZAWA; N MATSUNAMI; Y HAMAGUCHI; F MATSUDA; M KAWAICHI; T HONJO

  GENOMICS, Aug. 1993, Peer-reviewed

  
• THE HUMAN S-MU-BP-2, A DNA-BINDING PROTEIN-SPECIFIC TO THE SINGLE-STRANDED GUANINE-RICH SEQUENCE RELATED TO THE IMMUNOGLOBULIN-MU CHAIN SWITCH REGION

  Y FUKITA; TR MIZUTA; M SHIROZU; K OZAWA; A SHIMIZU; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1993, Peer-reviewed

  
• ISOLATION OF CDNA-ENCODING A BINDING-PROTEIN SPECIFIC TO 5'-PHOSPHORYLATED SINGLE-STRANDED-DNA WITH G-RICH SEQUENCES

  TR MIZUTA; Y FUKITA; T MIYOSHI; A SHIMIZU; T HONJO

  NUCLEIC ACIDS RESEARCH, Apr. 1993, Peer-reviewed

  
• THE COMPLETE MURINE IMMUNOGLOBULIN CLASS SWITCH REGION OF THE ALPHA-HEAVY CHAIN GENE-HIERARCHICAL REPETITIVE STRUCTURE AND RECOMBINATION BREAKPOINTS

  H ARAKAWA; T IWASATO; H HAYASHIDA; A SHIMIZU; T HONJO; H YAMAGISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1993, Peer-reviewed

  
• SYNTHESIS AND REGULATION OF TRANS-MESSENGER RNA ENCODING THE IMMUNOGLOBULIN-EPSILON HEAVY-CHAIN

  A SHIMIZU; T HONJO

  FASEB JOURNAL, Jan. 1993, Peer-reviewed

  
• BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF THE DNA-BINDING PROTEIN (RBP-J-KAPPA) TO MOUSE J-KAPPA RECOMBINATION SIGNAL SEQUENCE

  Y HAMAGUCHI; Y YAMAMOTO; H IWANARI; S MARUYAMA; T FURUKAWA; N MATSUNAMI; T HONJO

  JOURNAL OF BIOCHEMISTRY, Sep. 1992, Peer-reviewed

  
• BIASED DISTRIBUTION OF RECOMBINATION SITES WITHIN S-REGIONS UPON IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA AND LIPOPOLYSACCHARIDE

  T IWASATO; H ARAKAWA; A SHIMIZU; T HONJO; H YAMAGISHI

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 1992, Peer-reviewed

  
• EXPRESSION OF MURINE INTERLEUKIN-7 IN A MURINE GLIOMA CELL-LINE RESULTS IN REDUCED TUMORIGENICITY INVIVO

  T AOKI; K TASHIRO; S MIYATAKE; T KINASHI; T NAKANO; Y ODA; H KIKUCHI; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 1992

  
• MAPPING OF THE NU-GENE USING CONGENIC NUDE STRAINS AND INSITU HYBRIDIZATION

  Y TAKAHASHI; A SHIMIZU; T SAKAI; Y ENDO; N OSAWA; H SHISA; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 1992, Peer-reviewed

  
• A TRANSGENIC MODEL OF AUTOIMMUNE HEMOLYTIC-ANEMIA

  M OKAMOTO; M MURAKAMI; A SHIMIZU; S OZAKI; T TSUBATA; S KUMAGAI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 1992, Peer-reviewed

  
• THE DROSOPHILA RBP-J-KAPPA GENE ENCODES THE BINDING-PROTEIN FOR THE IMMUNOGLOBULIN J-KAPPA RECOMBINATION SIGNAL SEQUENCE

  T FURUKAWA; M KAWAICHI; N MATSUNAMI; H RYO; Y NISHIDA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1991, Peer-reviewed

  
• Expression of the RAG-2 Gene in Murine Central Nervous System Tumor Cell Lines.

  Aoki, T; Tashiro, K; Miyatake, S; Nakano, T; Oda, Y; Kikuchi, H; Honjo, T

  Biochem. Biophys. Res. Commun, Nov. 1991

  
• Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene

  A. Shimizu; M.C. Nussenzweig; H. Han; M. Sanchez; T. Honjo

  Journal of Experimental Medicine, Jun. 1991, Peer-reviewed

  
• Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines.

  Tashiro, K; Kinashi, T; Anderson, S. J; Lee, K. H; Tohyama, K; Ogawa, M; Takahashi, M; Kawaichi, M; Honjo, T

  Immunol. Lett., May 1991

  
• Different Stromal Cell Lines Support Lineage-selective Differentiation of the Multipotential Bone Marrow Stem Cell Clone LyD9.

  Lee, K. H; Kinashi, T; Tohyama, K; Tashiro, K; Funato, N; Hama, K; Honjo, T

  J. Exp. Med., May 1991

  
• Premature Expression of the Macrophage Colony-stimulating Factor Receptor on a Multipotential Stem Cell Line Does Not Alter Differentiation Lineages Controlled by Stromal Cells Used for Coculture.

  Kinashi, T; Lee, K. H; Ogawa, M; Tohyama, K; Tashiro, K; Fukunaga, R; Nagata, S; Honjo, T

  J. Exp. Med., May 1991

  
• THE NUCLEOLAR LOCALIZATION SIGNAL OF THE HTLV-I PROTEIN-P27REX IS IMPORTANT FOR STABILIZATION OF IL-2 RECEPTOR ALPHA-SUBUNIT MESSENGER-RNA BY P27REX

  KN WHITE; T NOSAKA; H KANAMORI; M HATANAKA; T HONJO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1991

  
• Shared partners in receptors

  Tasuku Honjo

  Current Biology, 1991, Peer-reviewed

  
• Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells

  T.-R. Mizuta; N. Suzuki; A. Shimizu; T. Honjo

  Journal of Biological Chemistry, 1991, Peer-reviewed

  
• Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic μ chain and constant regions of endogenous isotypes

  H. Han; M. Okamoto; T. Honjo; A. Shimizu

  International Immunology, 1991, Peer-reviewed

  
• The membrane exons of the pseudo-γ-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the γ1 gene

  K. Kinoshita; A. Shimizu; T. Honjo

  Immunology Letters, 1991, Peer-reviewed

  
• Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin

  K. Kuze; A. Shimizu; T. Honjo

  International Immunology, 1991, Peer-reviewed

  
• HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.

  H Kanamori; N Suzuki; H Siomi; T Nosaka; A Sato; H Sabe; M Hatanaka; T Honjo

  The EMBO Journal, Dec. 1990, Peer-reviewed

  
• MALIGNANT TRANSFORMATION OF AN INTERLEUKIN-5-DEPENDENT HEMATOPOIETIC-CELL CLONE BY AUTOCRINE SECRETION OF INTERLEUKIN-5

  K TOHYAMA; KH LEE; K TASHIRO; T KINASHI; T HONJO

  ACTA HAEMATOLOGICA JAPONICA, Dec. 1990, Peer-reviewed

  
• ESTABLISHMENT OF AN INTERLEUKIN-5-DEPENDENT SUBCLONE FROM AN INTERLEUKIN-3-DEPENDENT MURINE HEMATOPOIETIC PROGENITOR-CELL LINE, LYD9, AND ITS MALIGNANT TRANSFORMATION BY AUTOCRINE SECRETION OF INTERLEUKIN-5

  K TOHYAMA; KH LEE; K TASHIRO; T KINASHI; T HONJO

  EMBO JOURNAL, Jun. 1990

  
• Growth factors involved in lymphocyte differentiation.

  Kinashi, T; Tashiro, K; Lee, K. H; Inaba, K; Tohyama, K; Palacios, R; Honjo, T

  Phil. Trans. R. Soc. Lond. B. Biol. Sci., May 1990

  
• MOLECULAR ANALYSIS OF A CHROMOSOMAL TRANSLOCATION, T(9-14)(P13-Q32), IN A DIFFUSE LARGE-CELL LYMPHOMA CELL-LINE EXPRESSING THE KI-1 ANTIGEN

  H OHNO; T FURUKAWA; S FUKUHARA; SQ ZONG; H KAMESAKI; TB SHOWS; MM LEBEAU; TW MCKEITHAN; T KAWAKAMI; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1990

  
• Why are multiple chains required for the interleukin 2 receptor?

  Yuji Saito; Tasuku Honjo

  Progress in Growth Factor Research, 1990, Peer-reviewed

  
• IMMUNOGLOBULIN DOUBLE ISOTYPE EXPRESSION BY TRANS-MESSENGER RNA IN A HUMAN MU-CHAIN TRANSGENIC MOUSE

  A SHIMIZU; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  RECOMBINANT SYSTEMS IN PROTEIN EXPRESSION, 1990, Peer-reviewed

  
• Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

  Paschalis Sideras; Tatsunobu-ryushin Mizuta; Hiroshi Kanamorl; Noboru Suzuki; Masaya Okamoto; Kogo Kuze; Hitoshi Ohno; Shoichi Dol; Shirou Fukuhara; Mohammed Sawkat Hassan; Lennart Hammarstöm; Smith Edward; Akira Shimzu; Tasuku Honjo

  International Immunology, Nov. 1989, Peer-reviewed

  
• MULTIPLE EFFECTS OF HUMAN RECOMBINANT INTERLEUKIN-4 ON HUMAN MYELOID MONOCYTE CELL-LINES

  T NOMA; H NAKAKUBO; K HAMA; T HONJO

  IMMUNOLOGY LETTERS, Jun. 1989, Peer-reviewed

  
• T-CELLS FROM EOSINOPHILIC PATIENTS PRODUCE INTERLEUKIN-5 WITH INTERLEUKIN-2 STIMULATION

  H ENOKIHARA; S FURUSAWA; H NAKAKUBO; H KAJITANI; S NAGASHIMA; K SAITO; H SHISHIDO; Y HITOSHI; K TAKATSU; T NOMA; A SHIMIZU; T HONJO

  BLOOD, May 1989, Peer-reviewed

  
• STRUCTURE AND FUNCTION OF LYMPHOKINES AND THEIR RECEPTORS

  A SHIMIZU; T KINASHI; Y ISHIDA; T HONJO

  PROGRESS IN IMMUNOLOGY, VOL 7, 1989, Peer-reviewed

  
• MOLECULAR MECHANISM FOR IMMUNOGLOBULIN DOUBLE-ISOTYPE EXPRESSION

  A SHIMIZU; T KINASHI; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989, Peer-reviewed

  
• MOLECULAR MECHANISM FOR IMMUNOGLOBULIN DOUBLE-ISOTYPE EXPRESSION

  A SHIMIZU; T KINASHI; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989, Peer-reviewed

  
• Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse

  A. Shimizu; M.C. Nussenzweig; T.-R. Mizuta; P. Leder; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Jan. 1989, Peer-reviewed

  
• Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related

  T. Noma; H. Nakakubo; M. Sugita; S. Kumagi; M. Maeda; A. Shimizu; T. Honjo

  Journal of Experimental Medicine, 1989, Peer-reviewed

  
• Effect of human recombinant interleukin 4 on in vitro granulopoiesis of human bone marrow cells

  Hiroshi Kajitani; Hideo Enokihara; Satoshi Tsunogake; Naoto Takano; Kenji Saito; Shimpei Furusawa; Hideo Shishido; Takafumi Noma; Akira Shimizu; Tasuku Honjo

  Growth Factors, 01 Jan. 1989

  
• An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes

  T. Kinashi; K. Tashiro; K. Inaba; T. Takeda; R. Palacios; T. Honjo

  International Immunology, 1989, Peer-reviewed

  
• Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor α and β genes.

  Inaba, K; Inaba, M; Kinashi, T; Tashiro, K; Witmer-Pack, M; Crowley, M; Kaplan, G; Valinsky, J; Romani, N; Ikehara, S; Muramatsu, S; Honjo, T; Steinman, R.M

  J. Exp. Med., Dec. 1988

  
• BIASED EXPRESSION OF VARIABLE REGION GENE FAMILIES OF THE IMMUNOGLOBULIN HEAVY-CHAIN IN AUTOIMMUNE-PRONE MICE

  Y YAOITA; M TAKAHASHI; C AZUMA; Y KANAI; T HONJO

  JOURNAL OF BIOCHEMISTRY, Sep. 1988, Peer-reviewed

  
• Application of a human T cell line derived from a Sezary syndrome patient for human interleukin 4 assay

  Michiyuki Maeda; Takafumi Noma; Kazuaki Hama; Tasuku Honjo

  Immunology letters, Aug. 1988, Peer-reviewed

  
• PHYSICAL LINKAGE OF A VARIABLE REGION SEGMENT AND THE JOINING REGION SEGMENT OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  T SATO; F MATSUDA; HL KWANG; KS EUY; T HONJO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1988, Peer-reviewed

  
• Differentiation of a precursor cell with the germline context immunoglobulin gene into immunoglobulin-producing cells in vitro.

  Kinashi, T; Inaba, K; Tsubata, T; Tashiro, K; Palacios, R; Honjo, T

  Ann. N. Y. Acad. Sci., Jun. 1988, Peer-reviewed

  
• Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cell in vitro.

  Kinashi, T; Inaba, K; Tsubata, T; Tashiro, K; Palacios, R; Honjo, T

  Proc. Natl. Acad. Sci. U. S. A., Jun. 1988

  
• Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation

  Hideo Enokihara; Shigeki Nagasima; Takafumi Noma; Hiroshi Kajitani; Hiroyuki Hamaguchi; Kenji Saito; Shimpei Furusawa; Hideo Shishido; Tasuku Honjo

  Immunology letters, May 1988, Peer-reviewed

  
• HUMAN IMMUNOGLOBULIN-D SEGMENTS - ISOLATION OF A NEW D-SEGMENT AND POLYMORPHIC DELETION OF THE D1-SEGMENT

  SQ ZONG; S NAKAI; F MATSUDA; KH LEE; T HONJO

  IMMUNOLOGY LETTERS, Apr. 1988, Peer-reviewed

  
• DISPERSED LOCALIZATION OF D-SEGMENTS IN THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; KH LEE; S NAKAI; T SATO; M KODAIRA; SQ ZONG; H OHNO; S FUKUHARA; T HONJO

  EMBO JOURNAL, Apr. 1988, Peer-reviewed

  
• Both B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line

  Kenji Nakanishi; Tomohiro Yoshimoto; Yoshiya Katoh; Shiro Ono; Kiyoshi Matsui; Keisai Hiroishi; Takafumi Noma; Tasuku Honjo; Kiyoshi Takatsu; Kazuya Higashino; Toshiyuki Hamaoka

  The Journal of Immunology, Feb. 1988, Peer-reviewed

  
• Introduction and expression of the interleukin 2 receptor (tac) gene in hematopoietic stem cells with retrovirus vectors

  Shun-Ichi Takeda; Yasushi Hamaguchi; Shu Qin Zong; Kogo Kuze; Tasuku Honjo; Minoru Ishimoto; Toru Nakano; Yukihiko Kitamura

  Growth Factors, 1988, Peer-reviewed

  
• MULTIPLE RECOMBINATIONAL EVENTS IN PRIMATE IMMUNOGLOBULIN EPSILON-GENES AND ALPHA-GENES SUGGEST CLOSER RELATIONSHIP OF HUMANS TO CHIMPANZEES THAN TO GORILLAS

  S UEDA; F MATSUDA; T HONJO

  JOURNAL OF MOLECULAR EVOLUTION, 1988, Peer-reviewed

  
• A soluble \\'anchorminus\\' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses

  N. Kondo; S. Kondo; A. Shimizu; T. Honjo; J. Hamuro

  Immunology Letters, 1988, Peer-reviewed

  
• Molecular cloning and structure of the mouse interleukin-5 gene

  Tatsunobu-Ryushin Mizuta; Toshizumi Tanabe; Hiroshi Nakakubo; Takafumi Noma; Tasuku Honjo

  Growth factors, 1988, Peer-reviewed

  
• Fibroblast-dependent growth of mouse mast cells in vitro: Duplication of mast cell depletion in mutant mice of W/W(v) genotype

  J. Fujita; H. Nakayama; H. Onoue; Y. Kanakura; T. Nakano; H. Asai; S.-I. Takeda; T. Honjo; Y. Kitamura

  Journal of Cellular Physiology, Jan. 1988, Peer-reviewed

  
• MOLECULAR-CLONING AND STRUCTURE OF THE HUMAN INTERLEUKIN-5 GENE

  T TANABE; M KONISHI; T MIZUTA; T NOMA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1987, Peer-reviewed

  
• Nucleotide sequences of variable region segments of the immunoglobulin heavy chain of Xenopus laevis

  Yuriko Yamawaki-Kataoka; Tasuku Honjo

  Nucleic Acids Research, 24 Jul. 1987, Peer-reviewed

  
• HUMAN NEOPLASTIC B-CELLS EXPRESS MORE THAN 2 ISOTYPES OF IMMUNOGLOBULINS WITHOUT DELETION OF HEAVY-CHAIN CONSTANT-REGION GENES

  T KINASHI; T GODAL; Y NOMA; NR LING; Y YAOITA; T HONJO

  GENES & DEVELOPMENT, Jul. 1987, Peer-reviewed

  
• TRANSCRIPTION OF IL-2 RECEPTOR GENE IS STIMULATED BY ATL-DERIVED FACTOR PRODUCED BY HTLV-I(+) T-CELL LINES

  Y TAGAYA; Y TANIGUCHI; M NARAMURA; M OKADA; N SUZUKI; H KANAMORI; T NIKAIDO; T HONJO; J YODOI

  IMMUNOLOGY LETTERS, Jul. 1987, Peer-reviewed

  
• ENHANCEMENT OF THE INTERLEUKIN-2 RECEPTOR EXPRESSION ON T-CELLS BY MULTIPLE B-LYMPHOTROPIC LYMPHOKINES

  T NOMA; T MIZUTA; A ROSEN; T HIRANO; T KISHIMOTO; T HONJO

  IMMUNOLOGY LETTERS, Jul. 1987, Peer-reviewed

  
• A NOVEL FAMILY OF VARIABLE REGION GENES OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN

  KH LEE; F MATSUDA; T KINASHI; M KODAIRA; T HONJO

  JOURNAL OF MOLECULAR BIOLOGY, Jun. 1987, Peer-reviewed

  
• EXPRESSION AND FUNCTIONAL-CHARACTERIZATION OF ARTIFICIAL MUTANTS OF INTERLEUKIN-2 RECEPTOR

  S KONDO; M KINOSHITA; A SHIMIZU; Y SAITO; M KONISHI; H SABE; T HONJO

  NATURE, May 1987, Peer-reviewed

  
• Structure and Function of Interleukins 4 and 5

  Tasuku Honjo; Yoshio Yaoita; Tatsuo Kinashi; Yoshihiko Noma; Takayuki Naito; Chihiro Azuma; Eva Severinson; Paschalis Sideras; Susanna Bergstedt‐Lindqvist; Kiyoshi Takatsu; Akira Tominaga; Nobuhiko Harada; Toshizumi Tanabe; Mikio Konishi; Masazumi Takahashi; Fumihiko Matsuda

  Pediatrics International, 1987, Peer-reviewed

  
• RELATIONSHIP OF HUMAN CORD BLOOD MONONUCLEAR CELL-LINES, ESTABLISHED BY THE HTLV-I INTEGRATION, TO EXPRESSION OF T-CELL PHENOTYPES AND THE T-CELL RECEPTOR GENE REARRANGEMENT

  H MIWA; T UCHIDA; T KOBAYASHI; K KITA; S SHIRAKAWA; Y KOYANAGI; N YAMAMOTO; A SHIMIZU; T HONJO; M HATANAKA

  JOURNAL OF MOLECULAR AND CELLULAR IMMUNOLOGY, 1987, Peer-reviewed

  
• CLONING OF CDNA FOR HUMAN T-CELL REPLACING FACTOR (INTERLEUKIN-5) AND COMPARISON WITH THE MURINE HOMOLOG

  C AZUMA; T TANABE; M KONISHI; T KINASHI; T NOMA; F MATSUDA; Y YAOITA; K TAKATSU; L HAMMARSTROM; CIE SMITH; E SEVERINSON; T HONJO

  NUCLEIC ACIDS RESEARCH, Nov. 1986, Peer-reviewed

  
• A JOINING-DIVERSITY-JOINING COMPLEX GENERATED BY INVERSION MECHANISM AND A VARIABLE-DIVERSITY COMPLEX IN THE BETA-CHAIN GENE OF THE HUMAN T-CELL RECEPTOR

  K IKUTA; T OGURA; A SHIMIZU; T HONJO

  NUCLEIC ACIDS RESEARCH, Jun. 1986, Peer-reviewed

  
• Expression of functional human interleukin-2 receptor in mice T cells by cDNA transfection

  S. Kondo; A. Shimizu; M. Maeda; Y. Tagaya; J. Yodoi; T. Honjo

  Nature, Mar. 1986, Peer-reviewed

  
• INTERLEUKIN-2 RECEPTOR - STRUCTURE, FUNCTION, AND EXPRESSION

  H KANAMORI; S KONDO; M KINOSHITA; N SUZUKI; Y SAITO; H SABE; N MATSUNAMI; N ISHIDA; A SHIMIZU; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986

  
• Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines

  K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato

  Journal of Experimental Medicine, 1986, Peer-reviewed

  
• Organization and evolution of variable region genes of the human immunoglobulin heavy chain.

  Kodaira, M; Kinashi, T; Umemura, I; Matsuda, F; Noma, T; Ono, Y; Honjo, T

  J. Mol. Biol., 1986, Peer-reviewed

  
• Rat Lymphoid Cell Lines Producing Human T Cell Leukemia Virus.

  Junji Yodoi; Masafumi Okada; Yutaka Tagaya; Keisuke Teshigawara; Kiyoshi Fukui; Norio Ishida; Koh-ichi Ikuta; Michiyuki Maeda; Tasuku Honjo; Hisao Osawa; Tibor Diamantstein; Masatoshi Tateno; Takashi Yoshiki

  The Journal of Experimental Medicine, May 1985, Peer-reviewed

  
• Low frequency of somatic mutation in β-chain variable region genes of human T-cell receptors

  K. Ikuta; T. Ogura; A. Shimizu; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1985, Peer-reviewed

  
• II-2 receptor genes

  N. Ishida; T. Nikaido; S. Kondo; S. Takeda; A. Shimizu; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 1985, Peer-reviewed

  
• Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence

  A. Shimuzu; S. Kondo; S.-I. Takeda; J. Yodoi; N. Ishida; H. Sabe; H. Osawa; T. Diamantstein; T. Nikaido; T. Honjo

  Nucleic Acids Research, 1985, Peer-reviewed

  
• Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences

  S. Takeda; T. Naito; K. Hama; T. Noma; T. Honjo

  Nature, 1985, Peer-reviewed

  
• TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)

  J. Yodoi; K. Teshigawara; T. Nikaido; K. Fukui; T. Noma; T. Honjo; M. Takigawa; M. Sasaki; N. Minato; M. Tsudo

  Journal of Immunology, 1985, Peer-reviewed

  
• Molecular cloning and structure of the human interleukin 2 receptor gene

  N. Ishida; H. Kanamori; T. Noma; T. Nikaido; H. Sabe; N. Suzuki; A. Shimizu; T. Honjo

  Nucleic Acids Research, 1985, Peer-reviewed

  
• Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement

  M. Maeda; A. Shimizu; K. Ikuta; H. Okamoto; M. Kashihara; T. Uchiyama; T. Honjo; J. Yodoi

  Journal of Experimental Medicine, 1985, Peer-reviewed

  
• Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection

  Hisataka Sabe; Shigeru Kondo; Akira Shimizu; Yutaka Tagaya; Junji Yodoi; Nobuyuki Kobayashi; Masakazu Hatanaka; Norisada Matsunami; Michiyuki Maeda; Takafumi Noma; Tasuku Honjo

  Molecular Biology & Medicine, Dec. 1984, Peer-reviewed

  
• Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region

  Naoki Takahashi; Takafumi Noma; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, Aug. 1984, Peer-reviewed

  
• Genomic structure of HTLV (human T-cell leukemia virus): detection of defective genome and its amplification in MT-2 cells

  Nobuyuki Kobayashi; Hiroshi Konishi; Hisataka Sabe; Katsuya Shigesada; Takafumi Noma; Tasuku Honjo; Masakazu Hatanaka

  The EMBO Journal, Jun. 1984, Peer-reviewed

  
• DUPLICATED IMMUNOGLOBULIN GAMMA-2A GENES IN WILD MICE

  K FUKUI; Y HAMAGUCHI; A SHIMIZU; S NAKAI; K MORIWAKI; CH WANG; T HONJO

  JOURNAL OF MOLECULAR AND CELLULAR IMMUNOLOGY, 1984, Peer-reviewed

  
• Origin of Adult T-Cell Leukemia Virus

  Kiyoshi Fukui; Takafumi Noma; Kaoru Takeuchi; Nobuyuki Kobayashi; Masakazu Hatanaka; Tasuku Honjo

  Molecular Biology & Medicine, Nov. 1983, Peer-reviewed

  
• RECONSTITUTION OF ANTIGEN-SPECIFIC SUPPRESSOR ACTIVITY WITH TRANSLATION PRODUCTS OF MESSENGER-RNA

  M TANIGUCHI; T TOKUHISA; M KANNO; Y YAOITA; A SHIMIZU; T HONJO

  NATURE, 1982, Peer-reviewed

  
• LONG TERMINAL REPEAT-LIKE ELEMENTS FLANK A HUMAN-IMMUNOGLOBULIN EPSILON PSEUDOGENE THAT LACKS INTRONS

  S UEDA; S NAKAI; Y NISHIDA; H HISAJIMA; T HONJO

  EMBO JOURNAL, 1982, Peer-reviewed

  
• EXPRESSION OF LYMPHOCYTE SURFACE IGE DOES NOT REQUIRE SWITCH RECOMBINATION

  Y YAOITA; Y KUMAGAI; K OKUMURA; T HONJO

  NATURE, 1982, Peer-reviewed

  
• JAPANESE WILD MOUSE, MUS-MUSCULUS-MOLOSSINUS, HAS DUPLICATED IMMUNOGLOBULIN-GAMMA-2A GENES

  A SHIMIZU; Y HAMAGUCHI; Y YAOITA; K MORIWAKI; K KONDO; T HONJO

  NATURE, 1982, Peer-reviewed

  
• STRUCTURE OF A REARRANGED GAMMA-1 CHAIN GENE AND ITS IMPLICATION TO IMMUNOGLOBULIN CLASS-SWITCH MECHANISM

  M OBATA; T KATAOKA; S NAKAI; H YAMAGISHI; N TAKAHASHI; Y YAMAWAKIKATAOKA; T NIKAIDO; A SHIMIZU; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, Peer-reviewed

  
• DELETION OF IMMUNOGLOBULIN HEAVY-CHAIN GENES ACCOMPANIES THE CLASS SWITCH REARRANGEMENT

  Y YAOITA; T HONJO

  BIOMEDICAL RESEARCH-TOKYO, 1980, Peer-reviewed

  
• DELETION OF IMMUNOGLOBULIN HEAVY-CHAIN GENES FROM EXPRESSED ALLELIC CHROMOSOME

  Y YAOITA; T HONJO

  NATURE, 1980, Peer-reviewed

  
• Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes: Evidence for recent reshuffling

  Ryusuke Matsumura; Fumihiko Matsuda; Hitoshi Nagaoka; Junji Fujikura; Euy Kyun Shin; Euy Kyun Shin; Yosho Fukita; Yosho Fukita; Makoto Haino; Tasuku Honjo; Tasuku Honjo; Tasuku Honjo

  Journal of Immunology

  
• Recent Translocation of Variable and Diversity Segments of the Human Immunoglobulin Heavy Chain from Chromosome 14 to Chromosomes 15 and 16

  Hitoshi Nagaoka; Kazuo Ozawa; Fumihiko Matsuda; Hidenori Hayashida; Ryusuke Matsumura; Makoto Haino; Euy Kyun Shin; Yosho Fukita; Takashi Imai; Rakesh Anand; Kazushige Yokoyama; Toshihiko Eki; Eiichi Soeda; Tasuku Honjo

  Genomics

  
• Physical map of the 3′ region of the human immunoglobulin heavy chain locus: Clustering of autoantibody-related variable segments in one haplotype

  Euy Kyun Shin; Fumihiko Matsuda; Hitoshi Nagaoka; Yosho Fukita; Takashi Imai; Kazushige Yokoyama; Eiichi Soeda; Tasuku Honjo; Tasuku Honjo

  EMBO Journal

  
• Organization of variable region segments of the human immunoglobulin heavy chain: Duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments

  Fumihiko Matsuda; Euy Kyun Shin; Yasuhiko Hirabayashi; Hitoshi Nagaoka; Michihiro C. Yoshida; Michihiro C. Yoshida; Shu Quin Zong; Tasuku Honjo

  EMBO Journal

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  Journal of Biological Chemistry

  
• Comparison and Evolution of Human Immunoglobulin VH Segments Located in the 3′ 0.8-Megabase Region: Evidence for Unidirectional Transfer of Segmental Gene Sequences

  Makoto Haino; Hidenori Hayashida; Takashi Miyata; Euy Kyun Shin; Fumihiko Matsuda; Hitoshi Nagaoka; Ryusuke Matsumura; Shigeo Taka-ishi; Yosho Fukita; Junji Fujikura; Tasuku Honjo; Tasuku Honjo

  Journal of Biological Chemistry

  
• Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

  Zahra Sabouri; Il mi Okazaki; Il mi Okazaki; Reiko Shinkura; Nasim Begum; Hitoshi Nagaoka; Tasuku Honjo

  International Immunology

  
• AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model

  Y. Komeno; Y. Komeno; J. Kitaura; J. Kitaura; N. Watanabe-Okochi; N. Watanabe-Okochi; N. Kato; N. Kato; T. Oki; T. Oki; F. Nakahara; F. Nakahara; Y. Harada; H. Harada; R. Shinkura; H. Nagaoka; Y. Hayashi; T. Honjo; T. Kitamura; T. Kitamura

  Leukemia

  
• Uracil DNA glycosylase activity is dispensable for immunloglobulin class switch

  NA Begum; K Kinoshita; N Kakazu; M Muramatsu; H Nagaoka; R Shinkura; D Biniszkiewicz; LA Boyer; R Jaenisch; T Honjo

  SCIENCE, Aug. 2004

  
• Constitutive expression of AID leads to tumorigenesis

  Okazaki, I; H Hiai; N Kakazu; S Yamada; M Muramatsu; K Kinoshita; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2003

  
• The AID enzyme induces class switch recombination in fibroblasts.

  IM Okazaki

  NATURE REVIEWS IMMUNOLOGY, May 2002

  
• AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

  K Yoshikawa; IM Okazaki; T Eto; K Kinoshita; M Muramatsu; H Nagaoka; T Honjo

  SCIENCE, Jun. 2002

  
• Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

  H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo

  SCIENCE, Jan. 2001

  
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

  M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo

  CELL, Sep. 2000

  
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Lagelouse; A Gennery; Tezcan, I; F Ersoy; H Kayserili; AG Ugazio; N Brousse; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  CELL, Sep. 2000

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  H Kato; Y Taniguchi; H Kurooka; S Minoguchi; T Sakai; S NomuraOkazaki; K Tamura; T Honjo

  DEVELOPMENT, Oct. 1997

  
• Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice

  M Murakami; K Nakajima; K Yamazaki; T Muraguchi; T Serikawa; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 1997

  
• Conservation of the Notch signalling pathway in mammalian neurogenesis

  J delaPompa; A Wakeham; KM Correia; E Samper; S Brown; RJ Aguilera; T Nakano; T Honjo; TW Mak; J Rossant; RA Conlon

  DEVELOPMENT, Mar. 1997

  
• The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor

  T Honjo

  GENES TO CELLS, Jan. 1996

  
• In vitro development of primitive and definitive erythrocytes from different precursors

  T Nakano; H Kodama; T Honjo

  SCIENCE, May 1996

  
• Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor.

  本庶 佑

  Current Biology,5/,1416, 1995

  
• DISRUPTION OF THE MOUSE RBP-J-KAPPA GENE RESULTS IN EARLY EMBRYONIC DEATH

  C OKA; T NAKANO; A WAKEHAM; JL DELAPOMPA; C MORI; T SAKAI; S OKAZAKI; M KAWAICHI; K SHIOTA; TW MAK; T HONJO

  DEVELOPMENT, Oct. 1995

  
• ORAL-ADMINISTRATION OF LIPOPOLYSACCHARIDES ACTIVATES B-1 CELLS IN THE PERITONEAL-CAVITY AND LAMINA PROPRIA OF THE GUT AND INDUCES AUTOIMMUNE SYMPTOMS IN AN AUTOANTIBODY TRANSGENIC MOUSE

  M MURAKAMI; T TSUBATA; R SHINKURA; S NISITANI; M OKAMOTO; H YOSHIOKA; T USUI; S MIYAWAKI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 1994

  
• GENERATION OF LYMPHOHEMATOPOIETIC CELLS FROM EMBRYONIC STEM-CELLS IN CULTURE

  T NAKANO; H KODAMA; T HONJO

  SCIENCE, Aug. 1994

  
• EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 EXERTS ITS TRANSACTIVATING FUNCTION THROUGH INTERACTION WITH RECOMBINATION SIGNAL BINDING-PROTEIN RBP-J-KAPPA, THE HOMOLOG OF DROSOPHILA SUPPRESSOR OF HAIRLESS (VOL 13, PG 4973, 1994)

  U ZIMBERSTROBL; LJ STROBL; C MEITINGER; R HINRICHS; T SAKAI; T FURUKAWA; T HONJO; G BORNKAMM

  EMBO JOURNAL, Dec. 1994

  
• ANTIGEN-RECEPTOR CROSS-LINKING INDUCES PERITONEAL B-CELL APOPTOSIS IN NORMAL BUT NOT AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; T HONJO

  CURRENT BIOLOGY, Jan. 1994

  
• THE BCL-2 GENE-PRODUCT INHIBITS CLONAL DELETION OF SELF-REACTIVE B-LYMPHOCYTES IN THE PERIPHERY BUT NOT IN THE BONE-MARROW

  S NISITANI; T TSUBATA; M MURAKAMI; M OKAMOTO; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1993

  
• STRUCTURE AND PHYSICAL MAP OF 64 VARIABLE SEGMENTS IN THE 3(I)0.8-MEGABASE REGION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; Y FUKITA; S TAKAISHI; T IMAI; JH RILEY; R ANAND; E SOEDA; T HONJO

  NATURE GENETICS, Jan. 1993

  
• SIGNAL SEQUENCE TRAP - A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE-I MEMBRANE-PROTEINS

  K TASHIRO; H TADA; R HEILKER; M SHIROZU; T NAKANO; T HONJO

  SCIENCE, Jul. 1993

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY A T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  NATURE, Aug. 1993

  
• ANTIGEN-INDUCED APOPTOTIC DEATH OF LY-1 B-CELLS RESPONSIBLE FOR AUTOIMMUNE-DISEASE IN TRANSGENIC MICE

  M MURAKAMI; T TSUBATA; M OKAMOTO; A SHIMIZU; S KUMAGAI; H IMURA; T HONJO

  NATURE, May 1992

  
• A PROTEIN-BINDING TO THE J-KAPPA RECOMBINATION SEQUENCE OF IMMUNOGLOBULIN GENES CONTAINS A SEQUENCE RELATED TO THE INTEGRASE MOTIF

  N MATSUNAMI; Y HAMAGUCHI; Y YAMAMOTO; K KUZE; K KANGAWA; H MATSUO; M KAWAICHI; T HONJO

  NATURE, Dec. 1989

  
• CLONING OF COMPLEMENTARY-DNA ENCODING T-CELL REPLACING FACTOR AND IDENTITY WITH B-CELL GROWTH FACTOR-II

  T KINASHI; N HARADA; E SEVERINSON; T TANABE; P SIDERAS; M KONISHI; C AZUMA; A TOMINAGA; S BERGSTEDTLINDQVIST; M TAKAHASHI; F MATSUDA; Y YAOITA; K TAKATSU; T HONJO

  NATURE, Nov. 1986

  
• CLONING OF CDNA-ENCODING THE MURINE IGG1 INDUCTION FACTOR BY A NOVEL STRATEGY USING SP6 PROMOTER

  Y NOMA; P SIDERAS; T NAITO; S BERGSTEDTLINDQUIST; C AZUMA; E SEVERINSON; T TANABE; T KINASHI; F MATSUDA; Y YAOITA; T HONJO

  NATURE, Feb. 1986

  
• MOLECULAR-CLONING AND EXPRESSION OF CDNAS ENCODING THE HUMAN INTERLEUKIN-2 RECEPTOR

  WJ LEONARD; JM DEPPER; GR CRABTREE; S RUDIKOFF; J PUMPHREY; RJ ROBB; M KRONKE; PB SVETLIK; NJ PEFFER; TA WALDMANN; WC GREENE

  LYMPHOKINE RESEARCH, 1984

  
• IMMUNOGLOBULIN CLASS SWITCHING

  A SHIMIZU; T HONJO

  CELL, 1984

  
• IMMUNOGLOBULIN GENES

  T HONJO

  ANNUAL REVIEW OF IMMUNOLOGY, 1983

  
• SWITCH REGION OF IMMUNOGLOBULIN C-MU-GENE IS COMPOSED OF SIMPLE TANDEM REPETITIVE SEQUENCES

  T NIKAIDO; S NAKAI; T HONJO

  NATURE, 1981

  
• Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination

  本庶 佑

  Cell 18,559-568,18, 1979

  
• Organization of immnoglobulin heavy chain genes and allelic deletion model

  本庶 佑

  Proceeding of National Academy of Science 75,2140-2144,75, 1978

  

Misc.

• Transcriptional activity of EBNA2 through RBP-J

  T. Sakai; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 1997

  
• Ago2- and a miRNA-dependent control of topoisomerase 1 (TOP1) by activation-induced cytidine deaminase (AID) for antibody memory formation

  小林牧; 若栗浩幸; 清水正和; 日笠幸一郎; 松田文彦; 本庶佑

  日本分子生物学会年会プログラム・要旨集(Web), 2023

  
• Ago2とmiRNAはAID依存性の抗体遺伝子組換えにおけるDNA切断を促進するためにDNAトポイソメラーゼ1を減少させる

  小林牧; 若栗浩幸; 清水正和; 日笠幸一郎; 松田文彦; 本庶佑

  日本生化学会大会(Web), 2023

  
• B細胞発生におけるRBP‐Jの機能

  谷垣健二; 山本典生; 本庶佑

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 血漿交換療法と細胞療法 免疫抑制受容体PD-1と自己免疫疾患

  岡崎 拓; 田中 義正; 岩井 佳子; 西村 泰行; 松森 昭; 湊 長博; 本庶 佑

  リウマチ, Apr. 2001

  
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

  GJ Freeman; AJ Long; Y Iwai; Y Latchman; K Bourque; JA Brown; VA Boussiotis; DM Dorfman; T Chernova; H Nishimura; L Fitz; N Malenkovich; T Okazaki; M Byrne; H Horton; L Fouser; L Carter; AH Sharpe; B Carreno; M Collins; CR Wood; T Honjo

  BLOOD, Nov. 2000

  
• The B7-homologue, PD-L, is the ligand of the PD-1 immunoinhibitory receptor

  GJ Freeman; AJ Long; Y Iwai; K Bourque; T Chernova; H Nishimura; L Fitz; N Malenkovich; T Okazaki; M Byrne; H Horton; L Fouser; L Carter; B Carreno; M Collins; CR Wood; T Honjo

  FASEB JOURNAL, Apr. 2000

  
• 抗ヒトPD-1モノクローナル抗体作製とヒトPBMCにおけるPD-1発現の解析

  岩井 佳子; 川崎 明美; 八木田 秀雄; 西村 泰行; 本庶 佑

  生化学, Aug. 1999

  
• REPETITIVE SEQUENCES IN CLASS-SWITCH RECOMBINATION REGIONS OF IMMUNOGLOBULIN HEAVY-CHAIN GENES

  T KATAOKA; T MIYATA; T HONJO

  CELL, 1981

  
• DERMATOLOGICAL AND IMMUNOLOGICAL ABNORMALITIES IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 1989

  
• 免疫応答の多様性を支えるしくみ T細胞抗原受容体の多様性発現機構

  生田 宏一; 本庶 佑

  化学と生物, Jan. 1986

  
• CLONING OF HUMAN IMMUNOGLOBULIN-EPSILON CHAIN GENES - EVIDENCE FOR MULTIPLE C-EPSILON GENES

  Y NISHIDA; T MIKI; H HISAJIMA; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982

  
• CLONING OF MOUSE IMMUNOGLOBULIN-EPSILON GENE AND ITS LOCATION WITHIN THE HEAVY-CHAIN GENE-CLUSTER

  Y NISHIDA; T KATAOKA; N ISHIDA; S NAKAI; T KISHIMOTO; BOTTCHER, I; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981

  
• 切除可能非小細胞肺癌II-IIIA期における可溶性免疫因子の検討(WJOG12319LTR)

  谷崎 潤子; 黒田 浩章; 横山 俊秀; 高濱 誠; 庄田 浩康; 中村 敦; 北村 嘉隆; 豆鞘 伸昭; 門田 嘉久; 光岡 茂樹; 沖塩 協一; 岡田 守人; 坂井 和子; 千葉 康敬; 西尾 和人; 茶本 健司; 本庶 佑; 山本 信之; 中川 和彦; 林 秀敏

  肺癌, Nov. 2022

  
• Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.

  Ryusuke Hatae; Kenji Chamoto; Young Hak Kim; Kazuhiro Sonomura; Kei Taneishi; Shuji Kawaguchi; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Maryam Akrami; Sidonia Fagarasan; Izuru Masuda; Yasushi Okuno; Fumihiko Matsuda; Toyohiro Hirai; Tasuku Honjo

  JCI insight, 30 Jan. 2020

  Access this misc :

  
• The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR

  Maki Kobayashi; Misao Takemoto; Tasuku Honjo

  DNA Repair, 01 May 2017

  
• Cancer immunotherapies targeting the PD-1 signaling pathway

  Yoshiko Iwai; Junzo Hamanishi; Kenji Chamoto; Tasuku Honjo

  JOURNAL OF BIOMEDICAL SCIENCE, Apr. 2017

  Access this misc :

  
• トポイソメラーゼ1を介したAIDによる免疫グロブリン遺伝子の多様化

  小林 牧; 若栗 浩幸; 清水 正和; 日笠 幸一郎; 松田 文彦; 本庶 佑

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Activation-induced cytidine deaminase promotes oncogenesis of ultraviolet light-independent epidermal cancer from keratinocytic and melanocytic origin

  T. Nonaka; M. Uemura; H. Hiai; N. Minato; T. Honjo; K. Kinoshita

  FEBS JOURNAL, Sep. 2012

  
• An evolutionary view of the mechanism for immune and genome diversity

  Lucia Kato; Andre Stanlie; Nasim A. Begum; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo

  Journal of Immunology, 15 Apr. 2012

  
• Two Opposing roles of RBP-J in Notch signaling

  Kenji Tanigaki; Tasuku Honjo

  Current Topics in Developmental Biology, 2010

  
• B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

  Honjo Tasuku; Nagaoka Hitoshi; Tran Thinh Huy; Nakata Mikiyo; Suzuki Keiichiro; Begum Nasim A; Shinkura Reiko; Fagarasan Sidonia

  Nature Immunology, 06 Dec. 2009

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• AID遺伝子(Aicda)の発現は,刺激反応性及びBリンパ球特異的な2つのエンハンサー領域とそれに拮抗するサイレンサーにより制御される。

  TRAN Thinh Huy; 長岡仁; 中田幹代; BEGUM Nasim A; 新藏礼子; 本庶佑

  生化学, 25 Sep. 2009

  
• Involvement of IFN-gamma producing CD4(+) PD-1(+) T cells in lupus-prone NZB/W f1 mice

  Shimpei Kasagi; Seiji Kawano; Akio Morinobu; Saori Hatachi; Taku Okazaki; Yoshimasa Tanaka; Nagahiro Minato; Tasuku Honjo; Shunichi Kumagai

  ARTHRITIS AND RHEUMATISM, Sep. 2008

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase (Retraction of vol 281, pg 19115, 2006)

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2008

  
• PD-1 and PD-1 ligands: From discovery to clinical application

  Taku Okazaki; Tasuku Honjo

  International Immunology, Jul. 2007

  
• Regulation of lymphocyte development by Notch signaling

  Kenji Tanigaki; Tasuku Honjo

  Nature Immunology, May 2007

  
• Ectopic expression of activation-induced cytidine deaminase in ulcerative colitis-associated colorectal cancers

  Tadayuki Kou; Hiroyuki Marusawa; Yoko Endo; Hiroshi Nakase; Shigehiko Fujii; Kazuo Kinoshita; Takahiro Fujimori; Tasuku Honjo; Tsutomu Chiba

  GASTROENTEROLOGY, Apr. 2007

  
• High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis

  Junji Komori; Hiroyuki Marusawa; Takafumi Machimoto; Yoko Endo; Kazuo Kinoshita; Tadayuki Kou; Hironori Haga; Iwao Ikai; Shinji Uemoto; Tasuku Honjo; Tsutomu Chiba

  GASTROENTEROLOGY, Apr. 2007

  
• Notchシグナルによる細胞分化制御:シグナルの不活化と過剰活性化を可能にする2種類の遺伝子欠損マウスの比較解析からわかったこと

  矢部大介; 福田仁; 青木節代; 竹林慎治; 山本典生; 本庶佑

  日本薬学会年会要旨集, 05 Mar. 2007

  
• Role of AID in Tumorigenesis

  Il-mi Okazaki; Ai Kotani; Tasuku Honjo

  Advances in Immunology, 2007

  
• The PD-1-PD-L pathway in immunological tolerance

  T Okazaki; T Honjo

  TRENDS IN IMMUNOLOGY, Apr. 2006

  
• Rejuvenating exhausted T cells during chronic viral infection

  T Okazaki; T Honjo

  CELL, Feb. 2006

  
• In search of the best grant system

  Tasuku Honjo

  Science, 26 Aug. 2005

  
• Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy

  T Okazaki; T Honjo

  TRENDS IN MOLECULAR MEDICINE, Jul. 2005

  
• Dynamism of immune response to (4-hydroxy-3-nitrophenyl)acetyl hapten in AID deficient mice

  SHIMIZU Takeyuki; OSAKO Mina; MURAKAMI Akikazu; MURAMATSU Masamichi; HONJO Tasuku; AZUMA Takachika

  日本免疫学会総会・学術集会記録, 2005

  
• Emu-cmycトランスジェニックマウスに発症するB細胞リンパ腫におけるAIDの関与の検討

  幸谷愛; 嘉数直樹; 鶴山竜昭; 岡崎一美; 村松正道; 本庶佑

  臨床血液, 2005

  
• A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.

  Kotani A; Okazaki I; Muramatsu M; Kinoshita K; Begum N; Nakajima T; Saito H; Honjo T

  Proc. Natl. Acad. Sci. USA., 2005

  
• Notchシグナルを負に制御する因子Mintによる神経発生の制御

  福田仁; 矢部大介; 山田秀一; 辻正幸; 竹林慎治; 山本典生; 新蔵礼子; 高橋淳; 橋本信夫; 真貝洋一; 本庶佑

  日本脳神経外科学会総会抄録集(CD-ROM), 2005

  
• Response to comment on "uracil DNA glycosylase activity is dispensable for immunoglobulin class switch"

  NA Begum; T Honjo

  SCIENCE, Dec. 2004

  
• T細胞分化におけるMINTの機能解析

  辻正幸; 新蔵礼子; 矢部大介; 山本典生; 本庶佑

  日本免疫学会総会・学術集会記録, 05 Nov. 2004

  
• 臨床応用を目的とした可溶性PD-1組換え蛋白の大量精製と抗腫瘍効果の検討

  寺脇 正剛; 田中 義正; 石田 昌義; 岡崎 拓; 江 芳; 湊 長博; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• The role of autoantibodies against cardiac troponin I in autoimmune dilated cardiomyopathy

  R Nishio; A Matsumori; T Okazaki; Y Tanaka; T Mitsuiye; A Mizoguchi; H Hiai; N Minato; T Honjo

  JOURNAL OF CARDIAC FAILURE, Aug. 2004

  
• AIDトランスジェニックマウスにおけるsomatic hypermutationターゲットの検討

  幸谷愛; 岡崎一美; 村松正道; 木下和生; 本庶佑

  臨床血液, 2004

  
• Domain organization of activation-induced cytidine deaminase (multiple letters)

  Jolanta Zaim; Andrzej M. Kierzek; Van-Thanh Ta; Tasuku Honjo

  Nature Immunology, Dec. 2003

  
• AIDによる抗体分子多様化のメカニズム (特集 免疫学研究)

  岡崎 一美; 村松 正道; 本庶 佑

  学術月報, Oct. 2003

  
• Preface

  Tasuku Honjo; Frederick Alt; Michael Neuberger

  Molecular Biology of B Cells, 18 Feb. 2003

  
• Molecular Biology of B Cells

  Tasuku Honjo; Frederick Alt; Michael Neuberger

  Molecular Biology of B Cells, 18 Feb. 2003

  
• Basic research for AIDS control. Immunology and pathology for HIV infection. Fiscal year 1999. Establishment of SDF-1 expression system in simian model, and search for new CXCR4 antagonists. Fiscal year 2000. Identification of targeted cells by HIV-1, usi

  田代啓; 大倉定之; 山下満左広; 速水正憲; 柴山史朗; 池川雅哉; 本庶佑; 高橋淳; 堀口聡士

  エイズ制御のための基礎研究 平成10-13年度, 2003

  
• 細胞傷害性T細胞におけるPD‐1/PD‐L1システムを介した活性抑制制御機構の解析

  石田昌義; 岩井佳子; 田中義正; 岡崎拓; 本庶佑; 湊長博

  日本免疫学会総会・学術集会記録, 31 Oct. 2002

  
• 脳特異的に発現するBTCL1/2cDNA解析

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本神経科学大会プログラム・抄録集, 07 Jul. 2002

  
• 膜タンパク質をコードする脳特異的遺伝子BTCL2 cDNAの解析

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本獣医学会学術集会講演要旨集, 01 Mar. 2002

  
• Human genetic defects in class-switch recombination (hyper-IgM syndromes)

  A Durandy; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, Oct. 2001

  
• 脳特異的に発現する膜型タンパク質をコードする新規遺伝子の単離

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本神経科学大会プログラム・抄録集, 26 Sep. 2001

  
• 脳特異的に発現する膜型タンパク質をコードする新規遺伝子の単離

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  神経化学, 01 Sep. 2001

  
• HIV‐1感染者血中SDF‐1タンパク濃度の上昇とAIDS発症との関連について

  池川雅哉; えん景利; 松本和子; 岩本愛吉; 中村哲也; 松下修三; 木村哲也; 本庶佑; 田代啓

  生化学, 25 Aug. 2001

  
• ESOP‐1タンパクの細胞培養液からの精製と機能解析

  田代啓; 池川雅哉; MORRISON A M; 加藤桂三; 仲野徹; 本庶佑

  生化学, 25 Aug. 2001

  
• 神経幹細胞より単離された分泌タンパク質SDNSFの神経系前駆細胞生存支持活性の解析

  辻 正幸; 戸田 弘紀; 三國 貴康; 高橋 淳; 田代 啓; 本庶 佑

  生化学, Aug. 2001

  
• マウス及びヒトにおけるPD-1及びPD-L1発現の組織学的解析

  岩井 佳子; 岡崎 拓; 田中 義正; 川崎 明美; 八木田 秀雄; 湊 長博; 本庶 佑

  生化学, Aug. 2001

  
• Palindromic but not G-rich sequences are targets of class switch recombination

  J Tashiro; K Kinoshita; T Honjo

  INTERNATIONAL IMMUNOLOGY, Apr. 2001

  
• Complex layers of genetic alteration in the generation of antibody diversity

  M Muramatsu; T Honjo

  TRENDS IN IMMUNOLOGY, Feb. 2001

  
• 低分子化合物,ONO‐4007のin vitro抗HIV/SHIV増殖抑制効果

  池川雅哉; 柴山史朗; 山下満左裕; 大倉定之; 松尾政芳; 芳賀久典; 多田秀明; 田代啓; 本庶佑

  日本エイズ学会誌, 20 Nov. 2000

  
• SDF‐1を産生するSIVの作成

  肖勇; 桑田岳夫; 宇賀神秀樹; 池川雅哉; 田代啓; 本庶佑; 速水正憲

  日本エイズ学会誌, 20 Nov. 2000

  
• 免疫抑制受容体PD-1のリガンドの単離とその意義

  岩井 佳子; 岡崎 拓; 西村 泰行; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• SDF-1発現組換えアデノウイルス投与マウスを用いたin vivo SDF-1遊走活性の定量的考察

  池川 雅哉; 田代 啓; 三國 貴康; 本庶 佑

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• T-independent immune response: New aspects of B cell biology

  S Fagarasan; T Honjo

  SCIENCE, Oct. 2000

  
• SDF‐1のin vivo CXCR4 down modulationおよびchemoattractant活性の定量的考察

  池川雅哉; 田代啓; 松本和子; 本庶佑

  生化学, 25 Aug. 2000

  
• 免疫抑制受容体PD-1のリガンドの単離とその意義

  岩井 佳子; 西村 泰行; 岡崎 拓; 本庶 佑

  生化学, Aug. 2000

  
• Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

  T Muto; M Muramatsu; M Taniwaki; K Kinoshita; T Honjo

  GENOMICS, Aug. 2000

  
• Differentiation and migration of B1 cells in GALT

  S Fagarasan; R Shinkura; T Kamata; F Nogaki; K Ikuta; T Honjo

  FASEB JOURNAL, Apr. 2000

  
• A germinal center specific gene, AID promotes isotype switching in a mouse B cell lymphoma cells.

  M Muramatsu; K Kinoshita; NO Davidson; Y Shinkai; T Honjo

  FASEB JOURNAL, Apr. 2000

  
• Unique and unprecedented recombination mechanisms in class switching - Commentary

  K Kinoshita; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, Apr. 2000

  
• Identification of a stimulus-dependent DNase I hypersensitive site between the I alpha and C alpha exons during immunoglobulin heavy chain class switch recombination

  SJ Ono; G Zhou; AKF Tai; M Inaba; K Kinoshita; T Honjo

  FEBS LETTERS, Feb. 2000

  
• B cell tolerance and autoimmunity

  T. Tsubata; T. Honjo

  Reviews in Immunogenetics, 2000

  
• Generation, expansion, migration and activation of mouse B1 cells

  S. Fagarasan; N. Watanabe; T. Honjo

  Immunological Reviews, 2000

  
• 時間蛍光分解法を応用いた高感度血中SDF‐1測定法の開発

  池川雅哉; 田代啓; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, 22 Nov. 1999

  
• The human immunoglobulin V-H locus

  F Matsuda; T Honjo

  IMMUNOLOGIST, Nov. 1999

  
• SDF-1発現組換えアデノウイルス投与によるCXCR4 down modulation

  池川 雅哉; 田代 啓; 三國 貴康; 斉藤 泉; 鐘ヶ江 裕美; 本庶 佑

  日本免疫学会総会・学術集会記録, Oct. 1999

  
• Notchシグナル活性化の分子機構:タンパク質プロセシングの重要性 (特集 Notchシグナリングの新展開--発生現象解明への鍵)

  黒岡 尚徳; 本庶 佑

  細胞工学, Sep. 1999

  
• Induction of germline transcription in the TCR gamma locus by Stat5: Implications for accessibility control by the IL-7 receptor

  SK Ye; K Maki; T Kitamura; S Sunaga; K Akashi; J Domen; IL Weissman; T Honjo; K Ikuta

  IMMUNITY, Aug. 1999

  
• Constitutive expression of CX3C chemokine fractalkine in mouse skin

  N Kanazawa; K Yoneda; K Tashiro; K Inaba; Y Miyachi; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1999

  
• HIV-1耐性遺伝子の研究

  田代啓; 池川雅哉; 矢部大介; 本庶佑

  日本臨牀, Apr. 1999, Invited

  
• Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region (vol 26, pg 5448, 1998)

  H Kurooka; K Kuroda; T Honjo

  NUCLEIC ACIDS RESEARCH, Mar. 1999

  
• Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants

  K. Tashiro; M. Ikegawa; D. Yabe; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 01 Jan. 1999

  
• Ligand-induced notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

  KURODA Kazuki; KUROOKA Hisanori; HONJO Tasuku

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Molecular mechanism of transcriptional activation by the Notch intracellular region/RBP-J complex.

  KUROOKA Hisanori; KURODA Kazuki; HONJO Tasuku

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Target specificity of immunoglobulin class switch recombination is not determined by S region sequence.

  TASHIRO Junko; KINOSHITA Kazuo; LEE Chung-Gi; HONJO Tasuku

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• 免疫グロブリンクラススイッチに伴って発現誘導される新規遺伝子のクローニング

  村松正道; 菅井学; 木下和生; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2

  T Sakai; Y Taniguchi; K Tamura; S Minoguchi; T Fukuhara; LJ Strobl; U Zimber-Strobl; GW Bornkamm; T Honjo

  JOURNAL OF VIROLOGY, Jul. 1998

  
• Identification of a new class of chemokine expressed in murine dendritic cells by the signal sequence trap method.

  N Kanazawa; T Nakamura; K Tashiro; K Morita; K Yoneda; K Inaba; S Imamura; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1998

  
• PD-1 regulates self-tolerance to prevent tissue destruction.

  H Nishimura; H Hiai; N Minato; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1998

  
• Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector

  Chikaya Moriya; Tatsuo Shioda; Kei Tashiro; Takashi Nagasawa; Masaya Ikegawa; Yukano Ohnishi; Atsushi Kato; Huiling Hu; Xiaomi Xin; Mohammad K. Hasan; Midori Maekawa; Yutaka Takebe; Yuko Sakai; Tasuku Honjo; Yoshiyuki Nagai

  FEBS Letters, 20 Mar. 1998

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  KATO Hisamune; TANIGUCHI Yoshihito; KUROOKA Hisanori; MINOGUCHI Shigeru; TAMURA Kumiko; HONJO Tasuku

  Keio journal of medicine, 01 Dec. 1997

  
• Raising Anti‐SDF‐1 Antibodies and SDF‐1 Protein Characterization.

  田代啓; 池川雅哉; 矢部大介; 谷垣健二; 中野伊知郎; 中むら智之; 小夫家和宏; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1997

  
• Molecular cloning and characterization of a novel cytokine obtained from the murine embryonic heart

  T Nakamura; D Yabe; T Honjo

  CIRCULATION, Oct. 1997

  
• シグナル・シークエンス・トラップ法を用いたマウス胎仔期心臓からの新たな小胞体カルシウム結合蛋白（calumenin）のクローニングとその解析

  矢部大介; 中邨智之; 金澤伸雄; 田代啓; 篠山重威; 本庶佑

  心筋の構造と代謝, 1997, Invited

  
• Molecular cloning and expression of a novel FK506-binding protein in murine embryonic heart by the signal sequence trap method

  T Nakamura; D Yabe; T Shioi; Y Furukawa; T Nakano; T Honjo

  CIRCULATION, Oct. 1996

  
• Functional conservation of mouse Notch receptor family members

  H Kato; T Sakai; K Tamura; S Minoguchi; Y Shirayoshi; Y Hamada; Y Tsujimoto; T Honjo

  FEBS LETTERS, Oct. 1996

  
• Carnitine palmitoyltransferase I protects from apoptosis mediated by de novo synthesis of ceramide

  PAUMEN Michael; MURAMATSU Masamichi; HONJO Tasuku

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• 転写因子RBP-Jkと結合する新しい蛋白質の解析

  谷口 善仁; 古川 貴久; TUN Tir; 本庶 佑

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Differential development of primitive and definitive erythrocytes culture.

  T Nakano; H Kodama; T Honjo

  EXPERIMENTAL HEMATOLOGY, Aug. 1996

  
• An approach of a Ig class switch to molecular mechanism elucidation.

  菅井学; 近藤滋; 中村元信; 木下和生; 西山英児; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, Jul. 1996

  
• Disruption of the mouse RBP-J(kappa) gene results in early embryonic death (vol 121, pg 3291, 1995)

  C Oka; T Nakano; A Wakeham; JL delaPompa; C Mori; T Sakai; S Okazaki; M Kawaichi; K Shiota; TW Mak; T Honjo

  DEVELOPMENT, Jan. 1996

  
• ORGANIZATION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; T HONJO

  CYTOGENETICS AND CELL GENETICS, 1994

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1994

  
• T-CELL-DERIVED COSTIMULATORY SIGNAL THROUGH THE CD40 MOLECULE RESCUES B-CELLS FROM SURFACE IMMUNOGLOBULIN-MEDIATED CELL-DEATH

  T TSUBATA; J WU; T HONJO

  JOURNAL OF CELLULAR BIOCHEMISTRY, Jan. 1993

  
• MOLECULAR-CLONING OF A PROTEIN-BINDING TO THE PROMOTER OF IG C-GAMMA-1 GERM LINE IN THE MOUSE

  E SEVERINSON; M LUNDGREN; TR MIZUTA; J STAVNEZER; T HONJO; A SHIMIZU

  JOURNAL OF CELLULAR BIOCHEMISTRY, Jan. 1993

  
• STRUCTURAL-ANALYSIS OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS USING THE YEAST ARTIFICIAL CHROMOSOME (YAC) SYSTEM

  T HONJO; F MATSUDA; EK SHIN; H NAGAOKA; Y FUKITA; S TAKAISHI; T IMAI; K YOKOYAMA; E SOEDA

  CYTOGENETICS AND CELL GENETICS, 1991

  
• CONTROL OF IL-2 RECEPTOR-ALPHA EXPRESSION BY IL-1, TUMOR-NECROSIS-FACTOR, AND IL-2 - COMPLEX REGULATION VIA ELEMENTS IN THE 5' FLANKING REGION

  G PLAETINCK; MC COMBE; P CORTHESY; P SPERISEN; H KANAMORI; T HONJO; M NABHOLZ

  JOURNAL OF IMMUNOLOGY, Nov. 1990

  
• TRANSCRIPTIONAL REGULATION ALONE DOES NOT EXPLAIN THE CONSTITUTIVE EXPRESSION OF THE INTERLEUKIN-2 RECEPTOR (TAC/L-CHAIN) IN HTLV-1 INFECTED-CELLS

  H KANAMORI; N SUZUKI; N ISHIDA; T HONJO

  IMMUNOLOGY LETTERS, Mar. 1989

  
• A NEW VECTOR AND RNASE H METHOD FOR THE SUBTRACTIVE HYBRIDIZATION

  K KUZE; A SHIMIZU; T HONJO

  NUCLEIC ACIDS RESEARCH, Jan. 1989

  
• ORGANIZATION OF HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN GENES

  F MATSUDA; KH LEE; S NAKAI; T SATO; SQ ZONG; T HONJO

  JAPANESE JOURNAL OF HUMAN GENETICS, Jun. 1988

  
• インターロイキンー4(ILー4)/(BSF-1)

  Takafumi Noma; 本庶 佑

  Nihon Rinsho. Japanese Journal of Clinical Medicine, May 1988

  
• MOUSE IMMUNOGLOBULIN ALLOTYPES - MULTIPLE DIFFERENCES BETWEEN THE NUCLEIC-ACID SEQUENCES OF THE IGEA AND IGEB ALLELES

  Y SHINKAI; H NAKAUCHI; T HONJO; K OKUMURA

  IMMUNOGENETICS, Apr. 1988

  
• Structure and Function of Interleukin 4 and 5

  Takafumi Noma; Tasuku Honjo

  Immunological Reviews, Feb. 1988

  
• IL-4

  Takafumi Noma; 本庶 佑

  代謝, 1988

  
• THE HUMAN IL-2 RECEPTOR GENE CONTAINS A POSITIVE REGULATORY ELEMENT THAT FUNCTIONS IN CULTURED-CELLS AND CELL-FREE-EXTRACTS

  N SUZUKI; N MATSUNAMI; H KANAMORI; N ISHIDA; A SHIMIZU; Y YAOITA; T NIKAIDO; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1987

  
• STRUCTURE AND ORGANIZATION OF HUMAN-IMMUNOGLOBULIN VARIABLE REGION OF THE HEAVY-CHAIN

  T KINASHI; F MATSUDA; KH LEE; M KODAIRA; T NOMA; T HONJO

  JAPANESE JOURNAL OF HUMAN GENETICS, Jun. 1986

  
• ORGANIZATION AND EXPRESSION OF LYMPHOCYTE RECEPTOR GENES

  T HONJO; M NISHI; T NIKAIDO; H SABE; J YODOI; N MATSUNAMI; N SUZUKI; S KONDO; A SHIMIZU; Y YAOITA

  DEVELOPMENT GROWTH & DIFFERENTIATION, 1985

  
• The molecular mechanisms of the immunoglobulin class switch

  Tasuku Honjo

  Immunology Today, 1982

  
• Organization and reorganization of immunoglobulin heavy-chain genes

  T. Honjo; T. Kataoka; Y. Yaoita; A. Shimizu; N. Takahashi; Y. Yamawaki-Kataoka; T. Nikaido; S. Nakai; M. Obata; T. Kawakami; Y. Nishida

  Cold Spring Harbor Symposia on Quantitative Biology, 1981

  
• HOMOLOGY OF IMMUNOGLOBULIN GENE BY HETERODUPLEX ANALYSIS

  S NAKAI; H YAMAGISHI; T HONJO

  JAPANESE JOURNAL OF GENETICS, 1980

  
• The AID Dilemma. Infection, or Cancer?

  Tasuku Honjo; Maki Kobayashi; Nasim Begum; Ai Kotani; Somayeh Sabouri; Hitoshi Nagaoka

  Advances in Cancer Research

  
• Preventing AID, a physiological mutator, from deleterious activation: Regulation of the genomic instability that is associated with antibody diversity

  Hitoshi Nagaoka; Thinh Huy Tran; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo

  International Immunology

  
• Molecular mechanism for generation of antibody memory

  Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A. Begum; Hitoshi Nagaoka; Il Mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo

  Philosophical Transactions of the Royal Society B: Biological Sciences

  
• Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory

  Masamichi Muramatsu; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Nasim A. Begum; Nasim A. Begum; Tasuku Honjo

  Advances in Immunology

  
• AID to overcome the limitations of genomic information by introducing somatic DNA alterations

  Tasuku Honjo; Tasuku Honjo; Tasuku Honjo; Tasuku Honjo; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Reiko Shinkura

  Proceedings of the Japan Academy Series B: Physical and Biological Sciences

  
• Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation

  Ilmi Okazaki; Kiyotsugu Yoshikawa; Kiyotsugu Yoshikawa; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Annals of the New York Academy of Sciences

  
• Uracil DNA glycosylase activity is dispensable for immunloglobulin class switch

  NA Begum; K Kinoshita; N Kakazu; M Muramatsu; H Nagaoka; R Shinkura; D Biniszkiewicz; LA Boyer; R Jaenisch; T Honjo

  SCIENCE, Aug. 2004

  
• Constitutive expression of AID leads to tumorigenesis

  Okazaki, I; H Hiai; N Kakazu; S Yamada; M Muramatsu; K Kinoshita; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2003

  
• AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

  Kiyotsugu Yoshikawa; Il-mi Okazaki; Tomonori Eto; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Science, 14 Jun. 2002

  
• The AID enzyme induces class switch recombination in fibroblasts

  Il-Mi Okazaki; Kazuo Kinoshita; Masamichi Muramatsu; Klyotsugu Yoshikawa; Tasuku Honjo

  Nature, 21 Mar. 2002

  
• Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

  H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo

  SCIENCE, Jan. 2001

  
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Lagelouse; A Gennery; Tezcan, I; F Ersoy; H Kayserili; AG Ugazio; N Brousse; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  CELL, Sep. 2000

  
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

  M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo

  CELL, Sep. 2000

  
• Molecular mechanism of immunoglobulin class switch recombination

  K Kinoshita; CG Lee; J Tashiro; M Muramatsu; XC Chen; K Yoshikawa; T Honjo

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1999

  
• Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

  H Nishimura; M Nose; H Hiai; N Minato; T Honjo

  IMMUNITY, Aug. 1999

  
• Notch signalling controls pancreatic cell differentiation

  A Apelqvist; H Li; L Sommer; P Beatus; DJ Anderson; T Honjo; MH de Angelis; U Lendahl; H Edlund

  NATURE, Aug. 1999

  
• Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

  R Shinkura; K Kitada; F Matsuda; K Tashiro; K Ikuta; M Suzuki; K Kogishi; T Serikawa; T Honjo

  NATURE GENETICS, May 1999

  
• Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

  K Kinoshita; J Tashiro; S Tomita; CG Lee; T Honjo

  IMMUNITY, Dec. 1998

  
• Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant

  C Winkler; W Modi; MW Smith; GW Nelson; XY Wu; M Carrington; M Dean; T Honjo; K Tashiro; D Yabe; S Buchbinder; E Vittinghoff; JJ Goedert; TR O'Brien; LP Jacobson; R Detels; S Donfield; A Willoughby; E Gomperts; D Vlahov; J Phair; SJ O'Brien

  SCIENCE, Jan. 1998

  
• Frequent but biased class switch recombination in the S mu flanking regions

  CG Lee; S Kondo; T Honjo

  CURRENT BIOLOGY, Feb. 1998

  
• The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

  F Matsuda; K Ishii; P Bourvagnet; K Kuma; H Hayashida; T Miyata; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 1998

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  H Kato; Y Taniguchi; H Kurooka; S Minoguchi; T Sakai; S NomuraOkazaki; K Tamura; T Honjo

  DEVELOPMENT, Oct. 1997

  
• Conservation of the Notch signalling pathway in mammalian neurogenesis

  J delaPompa; A Wakeham; KM Correia; E Samper; S Brown; RJ Aguilera; T Nakano; T Honjo; TW Mak; J Rossant; RA Conlon

  DEVELOPMENT, Mar. 1997

  
• Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice

  M Murakami; K Nakajima; K Yamazaki; T Muraguchi; T Serikawa; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 1997

  
• In vitro development of primitive and definitive erythrocytes from different precursors

  T Nakano; H Kodama; T Honjo

  SCIENCE, May 1996

  
• The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor.

  Genes to Cells, 1996

  
• Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

  K Tamura; Y Taniguchi; S Minoguchi; T Sakai; T Tun; T Furukawa; T Honjo

  CURRENT BIOLOGY, Dec. 1995

  
• DISRUPTION OF THE MOUSE RBP-J-KAPPA GENE RESULTS IN EARLY EMBRYONIC DEATH

  C OKA; T NAKANO; A WAKEHAM; JL DELAPOMPA; C MORI; T SAKAI; S OKAZAKI; M KAWAICHI; K SHIOTA; TW MAK; T HONJO

  DEVELOPMENT, Oct. 1995

  
• EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 EXERTS ITS TRANSACTIVATING FUNCTION THROUGH INTERACTION WITH RECOMBINATION SIGNAL BINDING-PROTEIN RBP-J-KAPPA, THE HOMOLOG OF DROSOPHILA SUPPRESSOR OF HAIRLESS

  U ZIMBERSTROBL; LJ STROBL; C MEITINGER; R HINRICHS; T SAKAI; T FURUKAWA; T HONJO; GW BORNKAMM

  EMBO JOURNAL, Oct. 1994

  
• GENERATION OF LYMPHOHEMATOPOIETIC CELLS FROM EMBRYONIC STEM-CELLS IN CULTURE

  T NAKANO; H KODAMA; T HONJO

  SCIENCE, Aug. 1994

  
• ORAL-ADMINISTRATION OF LIPOPOLYSACCHARIDES ACTIVATES B-1 CELLS IN THE PERITONEAL-CAVITY AND LAMINA PROPRIA OF THE GUT AND INDUCES AUTOIMMUNE SYMPTOMS IN AN AUTOANTIBODY TRANSGENIC MOUSE

  M MURAKAMI; T TSUBATA; R SHINKURA; S NISITANI; M OKAMOTO; H YOSHIOKA; T USUI; S MIYAWAKI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 1994

  
• ANTIGEN-RECEPTOR CROSS-LINKING INDUCES PERITONEAL B-CELL APOPTOSIS IN NORMAL BUT NOT AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; T HONJO

  CURRENT BIOLOGY, Jan. 1994

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY A T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  NATURE, Aug. 1993

  
• THE BCL-2 GENE-PRODUCT INHIBITS CLONAL DELETION OF SELF-REACTIVE B-LYMPHOCYTES IN THE PERIPHERY BUT NOT IN THE BONE-MARROW

  S NISITANI; T TSUBATA; M MURAKAMI; M OKAMOTO; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1993

  
• STRUCTURE AND PHYSICAL MAP OF 64 VARIABLE SEGMENTS IN THE 3(I)0.8-MEGABASE REGION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; Y FUKITA; S TAKAISHI; T IMAI; JH RILEY; R ANAND; E SOEDA; T HONJO

  NATURE GENETICS, Jan. 1993

  
• SIGNAL SEQUENCE TRAP - A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE-I MEMBRANE-PROTEINS

  K TASHIRO; H TADA; R HEILKER; M SHIROZU; T NAKANO; T HONJO

  SCIENCE, Jul. 1993

  
• THE DROSOPHILA HOMOLOG OF THE IMMUNOGLOBULIN RECOMBINATION SIGNAL BINDING-PROTEIN REGULATES PERIPHERAL NERVOUS-SYSTEM DEVELOPMENT

  T FURUKAWA; S MARUYAMA; M KAWAICHI; T HONJO

  CELL, Jun. 1992

  
• ANTIGEN-INDUCED APOPTOTIC DEATH OF LY-1 B-CELLS RESPONSIBLE FOR AUTOIMMUNE-DISEASE IN TRANSGENIC MICE

  M MURAKAMI; T TSUBATA; M OKAMOTO; A SHIMIZU; S KUMAGAI; H IMURA; T HONJO

  NATURE, May 1992

  
• CIRCULAR DNA IS EXCISED BY IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION

  T IWASATO; A SHIMIZU; T HONJO; H YAMAGISHI

  CELL, Jul. 1990

  
• A PROTEIN-BINDING TO THE J-KAPPA RECOMBINATION SEQUENCE OF IMMUNOGLOBULIN GENES CONTAINS A SEQUENCE RELATED TO THE INTEGRASE MOTIF

  N MATSUNAMI; Y HAMAGUCHI; Y YAMAMOTO; K KUZE; K KANGAWA; H MATSUO; M KAWAICHI; T HONJO

  NATURE, Dec. 1989

  
• CLONING OF CDNA-ENCODING THE MURINE IGG1 INDUCTION FACTOR BY A NOVEL STRATEGY USING SP6 PROMOTER

  Y NOMA; P SIDERAS; T NAITO; S BERGSTEDTLINDQUIST; C AZUMA; E SEVERINSON; T TANABE; T KINASHI; F MATSUDA; Y YAOITA; T HONJO

  NATURE, Feb. 1986

  
• CLONING OF COMPLEMENTARY-DNA ENCODING T-CELL REPLACING FACTOR AND IDENTITY WITH B-CELL GROWTH FACTOR-II

  T KINASHI; N HARADA; E SEVERINSON; T TANABE; P SIDERAS; M KONISHI; C AZUMA; A TOMINAGA; S BERGSTEDTLINDQVIST; M TAKAHASHI; F MATSUDA; Y YAOITA; K TAKATSU; T HONJO

  NATURE, Nov. 1986

  
• INTERLEUKIN 1A MESSENGER-RNA IN VIRUS-TRANSFORMED T-CELLS AND B-CELLS

  T NOMA; T NAKAMURA; M MAEDA; M OKADA; Y TANIGUCHI; Y TAGAYA; Y YAOITA; J YODOI; T HONJO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 1986

  
• MOLECULAR-CLONING OF CDNA-ENCODING HUMAN INTERLEUKIN-2 RECEPTOR

  T NIKAIDO; A SHIMIZU; N ISHIDA; H SABE; K TESHIGAWARA; M MAEDA; T UCHIYAMA; J YODOI; T HONJO

  NATURE, 1984

  
• Immunogloblin class switching

  Cell 36,801-803, 1984

  
• Immunoglobulin genes.

  Ann. Rev. Immunol., 1983

  
• ORGANIZATION OF THE CONSTANT-REGION GENE FAMILY OF THE MOUSE IMMUNOGLOBULIN HEAVY-CHAIN

  A SHIMIZU; N TAKAHASHI; Y YAOITA; T HONJO

  CELL, 1982

  
• SWITCH REGION OF IMMUNOGLOBULIN C-MU-GENE IS COMPOSED OF SIMPLE TANDEM REPETITIVE SEQUENCES

  T NIKAIDO; S NAKAI; T HONJO

  NATURE, 1981

  
• ORDERING OF MOUSE IMMUNOGLOBULIN HEAVY-CHAIN GENES BY MOLECULAR-CLONING

  A SHIMIZU; N TAKAHASHI; Y YAMAWAKIKATAOKA; Y NISHIDA; T KATAOKA; T HONJO

  NATURE, 1981

  
• Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination

  Cell 18,559-568, 1979

  
• Organization of immnoglobulin heavy chain genes and allelic deletion model

  Proceeding of National Academy of Science 75,2140-2144, 1978

  

Books and Other Publications

• 幸福感に関する生物学的随想

  本庶, 佑

  祥伝社, Apr. 2020

  Find Kyoto University's collection of books :

  
• いのちとは何か : 幸福・ゲノム・病

  本庶, 佑

  岩波書店, Dec. 2009

  Find Kyoto University's collection of books :

  
• がん免疫療法とは何か

  本庶 佑, Single work

  岩波新書, Apr. 2019, Not refereed

  
• 生命科学の未来

  本庶 佑

  藤原書店, Dec. 2018, Not refereed

  
• 遺伝子が語る生命像

  本庶 佑

  講談社ブルーバックス, Apr. 1986, Not refereed