基本情報

学位

• 医学博士(京都大学)

使用言語

• 英語
• 日本語

ID,URL

• J-Global ID

  200901068100773866

• 外部リンク

  http://www2.mfour.med.kyoto-u.ac.jp

researchmap URL

• https://researchmap.jp/read0012306

研究

研究キーワード

• 分子発生学
• 分子免疫学
• Molecular immunology

研究分野

• ライフサイエンス, 医化学
• ライフサイエンス, 分子生物学

論文

• Beneficial effects on T cells by photodynamic therapy with talaporfin enhance cancer immunotherapy.

  Ehab M Ezzaldeen; Tomonori Yaguchi; Ryotaro Imagawa; Mohamed A Soltan; Akira Hirata; Kosaku Murakami; Hirotake Tsukamoto; Manabu Muto; Tasuku Honjo; Kenji Chamoto

  International immunology, 2025年01月22日

  
• Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators

  Vaibhav Pal Singh; Shuhei Hirose; Misao Takemoto; Asmaa M. A. S. Farrag; Shin-ichi Sato; Tasuku Honjo; Kenji Chamoto; Motonari Uesugi

  Journal of the American Chemical Society, 2024年06月07日

  
• GENETIC-HETEROGENEITY IN BLAST CRISIS OF CHRONIC MYELOCYTIC-LEUKEMIA

  T IKEDA; K KITA; H MIWA; K KAWAKAMI; H ANAZAWA; T OHNO; T NOSAKA; M HATANAKA; T HONJO; S SHIRAKAWA

  LEUKEMIA RESEARCH, 1990年, 査読有り

  
• Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling

  Masato Ogishi; Koji Kitaoka; Kim L. Good-Jacobson; Darawan Rinchai; Baihao Zhang; Jun Wang; Vincent Gies; Geetha Rao; Tina Nguyen; Danielle T. Avery; Taushif Khan; Megan E. Smithmyer; Joseph Mackie; Rui Yang; Andrés Augusto Arias; Takaki Asano; Khoren Ponsin; Matthieu Chaldebas; Peng Zhang; Jessica N. Peel; Jonathan Bohlen; Romain Lévy; Simon J. Pelham; Wei-Te Lei; Ji Eun Han; Iris Fagniez; Maya Chrabieh; Candice Laine; David Langlais; Conor Gruber; Fatima Al Ali; Mahbuba Rahman; Caner Aytekin; Basilin Benson; Matthew J. Dufort; Clara Domingo-Vila; Kunihiko Moriya; Mark Shlomchik; Gulbu Uzel; Paul E. Gray; Daniel Suan; Kahn Preece; Ignatius Chua; Satoshi Okada; Shunsuke Chikuma; Hiroshi Kiyonari; Timothy I. Tree; Dusan Bogunovic; Philippe Gros; Nico Marr; Cate Speake; Richard A. Oram; Vivien Béziat; Jacinta Bustamante; Laurent Abel; Bertrand Boisson; Anne-Sophie Korganow; Cindy S. Ma; Matthew B. Johnson; Kenji Chamoto; Stéphanie Boisson-Dupuis; Tasuku Honjo; Jean-Laurent Casanova; Stuart G. Tangye

  Immunity, 2024年11月

  
• Administration of interleukin ‐5 or ‐10 activates peritoneal B‐1 cells and induces autoimmune hemolytic anemia in anti‐erythrocyte autoantibody‐transgenic mice

  Sazuku Nisitani; Takeshi Tsubata; Masao Murakami; Tasuku Honjo

  European Journal of Immunology, 1995年

  
• Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3

  Hisataka Sabe; Junko Kuno; Antonis Koromllas; Yuji Saito; Tatsuo Kinashi; Masamichi Ueda; Tetsurou Takamatsu; Michinari Hamaguchi; Toshiaki Kawakami; Tasuku Honjo

  International Immunology, 1991年11月

  
• Biochemical evidence for a third chain of the interleukin-2 receptor

  Y. Saito; H. Tada; H. Sabe; T. Honjo

  Journal of Biological Chemistry, 1991年

  
• Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells

  Yasushi Hamaguchi; Yuzuru Kanakura; Jun Fujita; Shun-Ichi Takeda; Toru Nakano; Seiichiro Tarui; Tasuku Honjo; Yukihiko Kitamura

  Journal of Experimental Medicine, 1987年01月01日

  
• Molecular basis for two different affinity states of the interleukin 2 receptor: Affinity conversion model

  S. Kondo; A. Shimizu; Y. Saito; M. Kinoshita; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1986年

  
• Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene

  Helena Islam; Maki Kobayashi; Tasuku Honjo

  International Immunology, 2019年08月01日

  
• PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8 + T cells and facilitates anti–PD-1 therapy

  Partha S. Chowdhury; Kenji Chamoto; Alok Kumar; Tasuku Honjo

  Cancer Immunology Research, 2018年11月01日

  
• Ape1 is dispensable for s-region cleavage but required for its repair in class switch recombination

  Jianliang Xu; Afzal Husain; Wenjun Hu; Tasuku Honjo; Maki Kobayashi

  Proceedings of the National Academy of Sciences of the United States of America, 2014年12月02日

  
• BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL

  Santosh K Gothwal; Ahmed M Refaat; Mikiyo Nakata; Andre Stanlie; Tasuku Honjo; Nasim A Begum

  Nucleic Acids Research, 2024年04月03日

  
• REARRANGEMENTS OF IMMUNOGLOBULIN GENES DURING DIFFERENTIATION AND EVOLUTION

  T HONJO; S NAKAI; Y NISHIDA; T KATAOKA; Y YAMAWAKIKATAOKA; N TAKAHASHI; M OBATA; A SHIMIZU; Y YAOITA; T NIKAIDO; N ISHIDA

  IMMUNOLOGICAL REVIEWS, 1981年

  
• 人生100年時代の「老い」を考える スペルミジンは脂肪酸酸化を直接活性化し、老化個体における抗腫瘍免疫を回復させる

  本庶 佑; Al Habsi Muna; 茶本 健司; 松本 健; 野村 紀通; Wu Yibo; Zhang Baihao; 仲島 由佳; 園村 和弘; Menzies Rosemary; 杉浦 悠毅; 野村 弥生; 松田 文彦; 岩田 想; 小椋 利彦; Fagarasan Sidonia

  日本生化学会大会プログラム・講演要旨集, 2021年11月

  
• Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

  K Shibahara; M Asano; Y Ishida; T Aoki; T Koike; T Honjo

  GENE, 1995年12月, 査読有り

  
• Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation

  M. Aida; N. Hamad; A. Stanlie; N. A. Begum; T. Honjo

  Proceedings of the National Academy of Sciences, 2013年04月

  
• Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells

  N. Watanabe; T. Nomura; T. Takai; T. Chiba; T. Honjo; T. Tsubata

  Scandinavian Journal of Immunology, 1998年, 査読有り

  
• MOLECULAR MECHANISMS FOR B-LYMPHOCYTE SELECTION - INDUCTION AND REGULATION OF ANTIGEN-RECEPTOR-MEDIATED APOPTOSIS OF MATURE B-CELLS IN NORMAL MICE AND THEIR DEFECT IN AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; S NISITANI; T HONJO

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1994年08月

  
• Spermidine – an old molecule with a new age-defying immune function

  Kenji Chamoto; Baihao Zhang; Masaki Tajima; Tasuku Honjo; Sidonia Fagarasan

  Trends in Cell Biology, 2023年09月

  
• Notch-RBP-Jシグナルは大脳皮質層形成を調節する(Notch-RBP-J signaling regulates cortical laminar fates)

  谷垣 健二; 山本 典生; 辻 正幸; 本庶 佑

  神経化学, 2004年08月

  
• ROLE OF IL-2-R INDUCING FACTOR (ADF) IN THE CONSTITUTIVE IL-2-R GENE-EXPRESSION IN ADULT T-CELL LEUKEMIA (ATL)

  J YODOI; T NIKAIDO; H SABE; K TESHIGAWARA; M OKADA; Y TAGAYA; N ISHIDA; A SHIMIZU; M MAEDA; T UCHIYAMA; T HONJO

  FEDERATION PROCEEDINGS, 1985年

  
• T-CELL REPLACING FACTOR INTERLEUKIN-5 INDUCES NOT ONLY B-CELL GROWTH AND DIFFERENTIATION, BUT ALSO INCREASED EXPRESSION OF INTERLEUKIN-2 RECEPTOR ON ACTIVATED B-CELLS

  N HARADA; M MATSUMOTO; N KOYAMA; A SHIMIZU; T HONJO; A TOMINAGA; K TAKATSU

  IMMUNOLOGY LETTERS, 1987年07月, 査読有り

  
• PRODUCTION AND CHARACTERIZATION OF THE EXTRACYTOPLASMIC PORTION OF THE HUMAN INTERLEUKIN-2 RECEPTOR

  A SHIMIZU; N KONDO; S KONDO; J HAMURO; T HONJO

  MOLECULAR BIOLOGY & MEDICINE, 1986年12月, 査読有り

  
• STRUCTURE AND FUNCTION OF THE INTERLEUKIN-2 RECEPTOR - AFFINITY CONVERSION MODEL

  A SHIMIZU; S KONDO; H SABE; N ISHIDA; T HONJO

  IMMUNOLOGICAL REVIEWS, 1986年, 査読有り

  
• Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

  Maki Kobayashi; Hiroyuki Wakaguri; Masakazu Shimizu; Koichiro Higasa; Fumihiko Matsuda; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2023年04月24日

  
• Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family

  Daisuke Hoshiyama; Hiroshi Suga; Naoyuki Iwabe; Mitsumasa Koyanagi; Naruo Nikoh; Kei-Ichi Kuma; Fumihiko Matsuda; Tasuku Honjo; Takashi Miyata

  Journal of Molecular Evolution, 1998年, 査読有り

  
• Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease - Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs

  T Akamizu; F Matsuda; J Okuda; H Li; H Kanda; T Watanabe; T Honjo; T Mori

  JOURNAL OF IMMUNOLOGY, 1996年10月, 査読有り

  
• HETEROGENEITY AND DIVERSITY OF IGM AND IGG LUPUS ANTICOAGULANTS IN AN INDIVIDUAL WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

  N NAKAMURA; C AZUMA; T AKAMIZU; H SUGAWA; F MATSUDA; N MITSUDA; T HONJO; T MORI; K YAMAJI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994年09月, 査読有り

  
• VARIABLE REGIONS OF IG HEAVY-CHAIN GENES ENCODING ANTITHYROTROPIN RECEPTOR ANTIBODIES OF PATIENTS WITH GRAVES-DISEASE

  EK SHIN; T AKAMIZU; F MATSUDA; H SUGAWA; J FUJIKURA; T MORI; T HONJO

  JOURNAL OF IMMUNOLOGY, 1994年02月, 査読有り

  
• POLYMORPHISM OF THE HUMAN-IMMUNOGLOBULIN VARIABLE REGION SEGMENT V1-4.1

  EK SHIN; F MATSUDA; S OZAKI; S KUMAGAI; O OLERUP; H STROM; MELCHERS, I; T HONJO

  IMMUNOGENETICS, 1993年06月, 査読有り

  
• HOMINOID EVOLUTION BASED ON THE STRUCTURES OF IMMUNOGLOBULIN EPSILON-GENES AND ALPHA-GENES

  S UEDA; Y WATANABE; H HAYASHIDA; T MIYATA; F MATSUDA; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986年, 査読有り

  
• HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

  Ahmed M. Refaat; Mikiyo Nakata; Afzal Husain; Hidetaka Kosako; Tasuku Honjo; Nasim A. Begum

  Cell Reports, 2023年03月, 査読有り

  この論文にアクセスする：

  
• IL-2 CAN SUPPORT GROWTH OF CD8(+) T-CELLS BUT NOT CD4(+) T-CELLS OF HUMAN IL-2 RECEPTOR BETA-CHAIN TRANSGENIC MICE

  M ASANO; Y ISHIDA; H SABE; M KONDO; K SUGAMURA; T HONJO

  JOURNAL OF IMMUNOLOGY, 1994年12月, 査読有り

  
• INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH

  Y ISHIDA; Y AGATA; K SHIBAHARA; T HONJO

  EMBO JOURNAL, 1992年11月, 査読有り

  
• EXPRESSION OF MURINE IL-2-RECEPTOR BETA-CHAIN ON THYMIC AND SPLENIC LYMPHOCYTE SUBPOPULATIONS AS REVEALED BY THE IL-2-INDUCED PROLIFERATIVE RESPONSE IN HUMAN IL-2-RECEPTOR ALPHA-CHAIN TRANSGENIC MICE

  M HATTORI; H OKAZAKI; Y ISHIDA; M ONUMA; S KANO; T HONJO; N MINATO

  JOURNAL OF IMMUNOLOGY, 1990年05月, 査読有り

  
• EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; M HATTORI; N MINATO; M KAWAICHI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1989年10月, 査読有り

  
• Effects of the deregulated expression of human interleukin-2 in transgenic mice

  Yasumasa Ishida; Masashi Kawaichi; Tasuku Honjo; Osamu Taguchi; Kayo Inaba; Nagahiro Minato; Miyuki Nishi

  International Immunology, 1989年, 査読有り

  
• IMMUNE DYSFUNCTIONS AND ACTIVATION OF NATURAL-KILLER-CELLS IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989年, 査読有り

  
• IMMUNE DYSFUNCTIONS AND ACTIVATION OF NATURAL-KILLER-CELLS IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989年, 査読有り

  
• Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.

  Nasim A Begum; Farazul Haque; Andre Stanlie; Afzal Husain; Samiran Mondal; Mikiyo Nakata; Takako Taniguchi; Hisaaki Taniguchi; Tasuku Honjo

  The EMBO journal, 2021年06月15日

  
• Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells

  Afzal Husain; Nasim Begum; Maki Kobayashi; Tasuku Honjo

  BIO-PROTOCOL, 2020年

  
• Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

  Azza Al Ismail; Afzal Husain; Maki Kobayashi; Tasuku Honjo; Nasim A Begum

  International Immunology, 2017年12月30日

  
• Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

  Samiran Mondal; Nasim A. Begum; Wenjun Hu; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2016年03月15日

  
• Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

  Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2015年04月

  
• Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining

  Andre Stanlie; Ashraf S. Yousif; Hideo Akiyama; Tasuku Honjo; Nasim A. Begum

  Molecular Cell, 2014年07月

  
• The Non-Canonical function of UNG in AID induced Antibody Gene Diversification

  Yousif Ashraf; Begum Nasim; Honjo Tasuku

  Frontiers in Immunology, 2013年

  
• Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Nisitani; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2002年07月, 査読有り

  
• Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

  H Han; K Tanigaki; N Yamamoto; K Kuroda; M Yoshimoto; T Nakahata; K Ikuta; T Honjo

  INTERNATIONAL IMMUNOLOGY, 2002年06月, 査読有り

  
• Induction of germline transcription in the human TCRγ locus by STAT51

  H. C. Lee; S. K. Ye; T. Honjo; K. Ikuta

  Journal of Immunology, 2001年07月01日, 査読有り

  
• Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice

  T Sakiyama; K Ikuta; S Nisitani; K Takatsu; T Honjo

  INTERNATIONAL IMMUNOLOGY, 1999年06月, 査読有り

  
• STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN PD-1 GENE (PDCD1)

  T SHINOHARA; M TANIWAKI; Y ISHIDA; M KAWAICHI; T HONJO

  GENOMICS, 1994年10月, 査読有り

  
• Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice.

  Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; N. Minato; M. Kawaichi; T. Honjo

  Princess Takamatsu symposia, 1988年, 査読有り

  
• EVIDENCE FOR THE INTERLEUKIN-2 DEPENDENT EXPANSION OF LEUKEMIC-CELLS IN ADULT T-CELL LEUKEMIA

  M MAEDA; N ARIMA; Y DAITOKU; M KASHIHARA; H OKAMOTO; T UCHIYAMA; K SHIRONO; M MATSUOKA; T HATTORI; K TAKATSUKI; K IKUTA; A SHIMIZU; T HONJO; J YODOI

  BLOOD, 1987年11月

  
• HUMAN-LYMPHOCYTE FC RECEPTOR FOR IGE - SEQUENCE HOMOLOGY OF ITS CLONED CDNA WITH ANIMAL LECTINS

  K IKUTA; M TAKAMI; CW KIM; T HONJO; T MIYOSHI; Y TAGAYA; T KAWABE; J YODOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987年02月, 査読有り

  
• Durable tumor remission in patients with platinum-resistant ovarian cancer receiving nivolumab.

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Yuko Hosoe; Satoshi Morita; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  JOURNAL OF CLINICAL ONCOLOGY, 2015年05月, 査読有り

  
• Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer.

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Masashi Kanai; Yukiko Mori; Shigemi Matsumoto; Toshinori Murayama; Shunsuke Chikuma; Satoshi Morita; Masayuki Yokode; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  JOURNAL OF CLINICAL ONCOLOGY, 2014年05月, 査読有り

  
• Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice

  T Nomura; H Han; MC Howard; H Yagita; H Yakura; T Honjo; T Tsubata

  INTERNATIONAL IMMUNOLOGY, 1996年06月

  
• Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

  Yasutoshi Agata; Akemi Kawasaki; Hiroyuki Nishimura; Yasumasa Ishida; Takeshi Tsubata; Hideo Yagita; Tasuku Honjo

  International Immunology, 1996年

  
• RECOMBINATION OF EXOGENOUS INTERLEUKIN-2 RECEPTOR GENE FLANKED BY IMMUNOGLOBULIN RECOMBINATION SIGNAL SEQUENCES IN A PRE-B CELL-LINE AND TRANSGENIC MICE

  M KAWAICHI; C OKA; R REEVES; M KINOSHITA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1991年09月, 査読有り

  
• A LARGER NUMBER OF L-CHAINS (TAC) ENHANCE THE ASSOCIATION RATE OF INTERLEUKIN-2 TO THE HIGH-AFFINITY SITE OF THE INTERLEUKIN-2 RECEPTOR

  Y SAITO; H SABE; N SUZUKI; S KONDO; T OGURA; A SHIMIZU; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1988年11月, 査読有り

  
• MOLECULAR MECHANISM FOR THE FORMATION OF THE HIGH-AFFINITY COMPLEX OF INTERLEUKIN-2 AND ITS RECEPTOR

  T OGURA; M KONISHI; N SUZUKI; S KONDO; H SABE; T HONJO

  MOLECULAR BIOLOGY & MEDICINE, 1988年04月, 査読有り

  
• Expression of interleukin 2 receptors on interleukin 3-dependent cell lines.

  Shigeo Koyasu; Junji Yodoi; Toshio Nikaido; Yutaka Tagaya; Yoshihisa Taniguchi; Tasuku Honjo; Ichiro Yahara

  Journal of Immunology, 1986年02月01日, 査読有り

  
• Soluble programmed cell death ligand 1 predicts prognosis for gastric cancer patients treated with nivolumab: Blood-based biomarker analysis for the DELIVER trial

  Hisato Kawakami; Yu Sunakawa; Eisuke Inoue; Ryo Matoba; Kenta Noda; Toshiyuki Sato; Chihiro Suminaka; Mami Yamaki; Yasuhiro Sakamoto; Ryohei Kawabata; Atsushi Ishiguro; Yusuke Akamaru; Yosuke Kito; Hiroshi Yabusaki; Jin Matsuyama; Masazumi Takahashi; Akitaka Makiyama; Hidetoshi Hayashi; Kenji Chamoto; Tasuku Honjo; Kazuhiko Nakagawa; Wataru Ichikawa; Masashi Fujii

  European Journal of Cancer, 2023年05月, 査読有り

  
• Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

  Kenji Chamoto; Tomonori Yaguchi; Masaki Tajima; Tasuku Honjo

  Nature Reviews Immunology, 2023年04月25日

  
• Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer

  Kentaro Tanaka; Kenji Chamoto; Sho Saeki; Ryusuke Hatae; Yuki Ikematsu; Kazuko Sakai; Nobuhisa Ando; Kazuhiro Sonomura; Shinsuke Kojima; Masanori Taketsuna; Young Hak Kim; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Tomoko Hirano; Fumihiko Matsuda; Toyohiro Hirai; Kazuto Nishio; Takuro Sakagami; Masanori Fukushima; Yoichi Nakanishi; Tasuku Honjo; Isamu Okamoto

  Science Translational Medicine, 2022年12月14日

  
• Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

  Shingo Matsushima; Masahiko Ajiro; Kei Iida; Kenji Chamoto; Tasuku Honjo; Masatoshi Hagiwara

  Science Translational Medicine, 2022年11月30日

  
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Al-Habsi; Kenji Chamoto; Ken Matsumoto; Norimichi Nomura; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Aprilia Maharani; Yuka Nakajima; Yibo Wu; Yayoi Nomura; Rosemary Menzies; Masaki Tajima; Koji Kitaoka; Yasuharu Haku; Sara Delghandi; Keiko Yurimoto; Fumihiko Matsuda; So Iwata; Toshihiko Ogura; Sidonia Fagarasan; Tasuku Honjo

  Science, 2022年10月28日

  
• B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

  Baihao Zhang; Alexis Vogelzang; Michio Miyajima; Yuki Sugiura; Yibo Wu; Kenji Chamoto; Rei Nakano; Ryusuke Hatae; Rosemary J. Menzies; Kazuhiro Sonomura; Nozomi Hojo; Taisaku Ogawa; Wakana Kobayashi; Yumi Tsutsui; Sachiko Yamamoto; Mikako Maruya; Seiko Narushima; Keiichiro Suzuki; Hiroshi Sugiya; Kosaku Murakami; Motomu Hashimoto; Hideki Ueno; Takashi Kobayashi; Katsuhiro Ito; Tomoko Hirano; Katsuyuki Shiroguchi; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan

  Nature, 2021年11月18日

  この論文にアクセスする：

  
• Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

  Masato Ogishi; Rui Yang; Caner Aytekin; David Langlais; Mathieu Bourgey; Taushif Khan; Fatima Al Ali; Mahbuba Rahman; Ottavia M. Delmonte; Maya Chrabieh; Peng Zhang; Conor Gruber; Simon J. Pelham; András N. Spaan; Jérémie Rosain; Wei-Te Lei; Scott Drutman; Matthew D. Hellmann; Margaret K. Callahan; Matthew Adamow; Phillip Wong; Jedd D. Wolchok; Geetha Rao; Cindy S. Ma; Yuka Nakajima; Tomonori Yaguchi; Kenji Chamoto; Samuel C. Williams; Jean-Francois Emile; Flore Rozenberg; Michael S. Glickman; Franck Rapaport; Gaspard Kerner; Garrett Allington; Ilhan Tezcan; Deniz Cagdas; Ferda O. Hosnut; Figen Dogu; Aydan Ikinciogullari; V. Koneti Rao; Leena Kainulainen; Vivien Béziat; Jacinta Bustamante; Silvia Vilarinho; Richard P. Lifton; Bertrand Boisson; Laurent Abel; Dusan Bogunovic; Nico Marr; Luigi D. Notarangelo; Stuart G. Tangye; Tasuku Honjo; Philippe Gros; Stéphanie Boisson-Dupuis; Jean-Laurent Casanova

  Nature Medicine, 2021年09月

  
• Critical role of the CD44 ^low CD62L ^low CD8 ⁺ T cell subset in restoring antitumor immunity in aged mice

  Yuka Nakajima; Kenji Chamoto; Takuma Oura; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2021年06月08日

  
• Circulation of gut-preactivated naïve CD8+T cells enhances antitumor immunity in B cell-defective mice

  Maryam Akrami; Rosemary Menzies; Kenji Chamoto; Michio Miyajima; Ryuji Suzuki; Hiroyuki Sato; Akiko Nishii; Michio Tomura; Sidonia Fagarasan; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2020年09月22日

  
• SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

  Afzal Husain; Jiangliang Xu; Hodaka Fujii; Mikiyo Nakata; Maki Kobayashi; Ji‐Yang Wang; Jan Rehwinkel; Tasuku Honjo; Nasim A Begum

  The EMBO Journal, 2020年06月08日, 査読有り

  
• RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

  Ziwei Yin; Maki Kobayashi; Wenjun Hu; Koichi Higashi; Nasim A. Begum; Ken Kurokawa; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 2020年05月26日

  
• Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

  Alok Kumar; Kenji Chamoto; Partha S Chowdhury; Tasuku Honjo

  eLife, 2020年03月03日, 査読有り

  この論文にアクセスする：

  
• Current issues and perspectives in PD-1 blockade cancer immunotherapy

  Chamoto, K.; Hatae, R.; Honjo, T.

  International Journal of Clinical Oncology, 2020年, 査読有り

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• Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma

  Megumi Goto; Kenji Chamoto; Keiko Higuchi; Saya Yamashita; Kenta Noda; Takuya Iino; Masahiro Miura; Toshinari Yamasaki; Osamu Ogawa; Makoto Sonobe; Hiroshi Date; Junzo Hamanishi; Masaki Mandai; Yoshimasa Tanaka; Shunsuke Chikuma; Ryusuke Hatae; Manabu Muto; Sachiko Minamiguchi; Nagahiro Minato; Tasuku Honjo

  Scientific Reports, 2019年12月01日

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• 免疫療法の新規バイオマーカー 進行NSCLCにおける可溶性免疫チェックポイント因子の役割(Novel biomarkers for immunotherapies The role of soluble immune-checkpoint factors in advanced NSCLC)

  Hayashi Hidetoshi; 茶本 健司; 冨樫 庸介; 中川 和彦; 本庶 佑

  肺癌, 2019年11月

  
• Novel biomarkers for immunotherapies The role of soluble immune-checkpoint factors in advanced NSCLC(和訳中)

  Hayashi Hidetoshi; 茶本 健司; 冨樫 庸介; 中川 和彦; 本庶 佑

  肺癌, 2019年11月, 査読有り

  
• Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553-563.

  Muramatsu M; Kinoshita K; Fagarasan S; Yamada S; Shinkai Y; Honjo T

  Journal of immunology (Baltimore, Md. : 1950), 2018年11月, 査読有り

  
• Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy

  P. S. Chowdhury; K. Chamoto; T. Honjo

  Journal of Internal Medicine, 2018年02月01日, 査読有り

  
• Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

  Michio Miyajima; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Matteo M. Guerrini; Yumi Tsutsui; Mikako Maruya; Alexis Vogelzang; Kenji Chamoto; Kurara Honda; Takatoshi Hikida; Satomi Ito; Hongyan Qin; Rikako Sanuki; Keiichiro Suzuki; Takahisa Furukawa; Yasushi Ishihama; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan

  NATURE IMMUNOLOGY, 2017年12月, 査読有り

  
• Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes

  Gabrielle McDonald; Carlos O. Medina; Monika Pilichowska; John F. Kearney; Reiko Shinkura; Erik Selsing; Henry H. Wortis; Tasuku Honjo; Thereza Imanishi-Kari

  Frontiers in Immunology, 2017年09月13日, 査読有り

  
• Role of PD-1 in Immunity and Diseases

  Kenji Chamoto; Muna Al-Habsi; Tasuku Honjo

  EMERGING CONCEPTS TARGETING IMMUNE CHECKPOINTS IN CANCER AND AUTOIMMUNITY, 2017年, 査読有り

  
• Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

  Kenji Chamoto; Partha S. Chowdhury; Alok Kumar; Kazuhiro Sonomura; Fumihiko Matsuda; Sidonia Fagarasan; Tasuku Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017年01月, 査読有り

  
• Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.

  Zhang Baihao; Chikuma Shunsuke; Hori Shohei; Fagarasan Sidonia; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 2016年07月07日

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• Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

  Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo

  Nature Communications, 2016年02月04日

  この論文にアクセスする：

  
• Safety and antitumor activity of Anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer

  Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Toshinori Murayama; Masashi Kanai; Yukiko Mori; Shigemi Matsumoto; Shunsuke Chikuma; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Yuko Hosoe; Satoshi Morita; Masayuki Yokode; Akira Shimizu; Tasuku Honjo; Ikuo Konishi

  Journal of Clinical Oncology, 2015年12月01日

  
• Molecular Mechanisms of AID Function

  Nasim A. Begum; Hitoshi Nagaoka; Maki Kobayashi; Tasuku Honjo

  Molecular Biology of B Cells, 2015年

  
• Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

  Tung Nguyen; Jianliang Xu; Shunsuke Chikuma; Hiroshi Hiai; Kazuo Kinoshita; Kyoji Moriya; Kazuhiko Koike; Gian Paolo Marcuzzi; Herbert Pfister; Tasuku Honjo; Maki Kobayashi

  INTERNATIONAL IMMUNOLOGY, 2014年07月, 査読有り

  
• Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten

  Akikazu Murakami; Hayato Moriyama; Mina Osako-Kabasawa; Kanako Endo; Miyuki Nishimura; Keiko Udaka; Masamichi Muramatsu; Tasuku Honjo; Takachika Azuma; Takeyuki Shimizu

  INTERNATIONAL IMMUNOLOGY, 2014年04月

  
• Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten.

  Akikazu Murakami; Hayato Moriyama; Mina Osako-Kabasawa; Kanako Endo; Miyuki Nishimura; Keiko Udaka; Masamichi Muramatsu; Tasuku Honjo; Takachika Azuma; Takeyuki Shimizu

  International immunology, 2014年04月

  
• C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.

  Sabouri Somayeh; Kobayashi Maki; Begum Nasim A; Xu Jianliang; Hirota Kouji; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 2014年02月11日

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• A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

  Taku Okazaki; Shunsuke Chikuma; Yoshiko Iwai; Sidonia Fagarasan; Tasuku Honjo

  Nature Immunology, 2013年12月, 査読有り

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• RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.

  Guoxin Liang; Kouichi Kitamura; Zhe Wang; Guangyan Liu; Sajeda Chowdhury; Weixin Fu; Miki Koura; Kousho Wakae; Tasuku Honjo; Masamichi Muramatsu

  Proceedings of the National Academy of Sciences of the United States of America, 2013年02月05日

  
• In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression

  Le Thi Huong; Le Thi Huong; Maki Kobayashi; Mikiyo Nakata; Go Shioi; Hitoshi Miyachi; Tasuku Honjo; Hitoshi Nagaoka

  PLoS ONE, 2013年, 査読有り

  
• The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation

  Nasim A. Begum; Andre Stanlie; Mikiyo Nakata; Hideo Akiyama; Tasuku Honjo

  Journal of Biological Chemistry, 2012年09月21日, 査読有り

  
• Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability

  Nasim A. Begum; Tasuku Honjo

  Biochemistry, 2012年07月03日, 査読有り

  
• TRIM28 prevents autoinflammatory T cell development in vivo

  Shunsuke Chikuma; Naomasa Suita; Il-Mi Okazaki; Shiro Shibayama; Tasuku Honjo

  Nature Immunology, 2012年06月, 査読有り

  
• The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination

  Andre Stanlie; Nasim A. Begum; Hideo Akiyama; Tasuku Honjo

  PLoS Genetics, 2012年04月, 査読有り

  
• Cartilage-specific RBPjκ-dependent and -independent notch signals regulate cartilage and bone development

  Anat Kohn; Yufeng Dong; Anthony J. Mirando; Alana M. Jesse; Tasuku Honjo; Michael J. Zuscik; Regis J. O'Keefe; Matthew J. Hilton

  Development, 2012年03月, 査読有り

  
• Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

  Lucia Kato; Nasim A. Begum; A. Maxwell Burroughs; Tomomitsu Doi; Jun Kawai; Carsten O. Daub; Takahisa Kawaguchi; Fumihiko Matsuda; Yoshihide Hayashizaki; Tasuku Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012年02月, 査読有り

  この論文にアクセスする：

  
• The AID dilemma: infection, or cancer?

  Honjo Tasuku; Kobayashi Maki; Begum Nasim; Kotani Ai; Sabouri Somayeh; Nagaoka Hitoshi

  Advances in cancer research, 2012年, 査読有り

  
• Activation-Induced Cytidine Deaminase Expression in CD4 T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.

  Qin, H; Suzuki, K; Nakata, M; Chikuma, S; Izumi, N; Thi Huong, L; Maruya, M; Fagarasan, S; Busslinger, M; Honjo, T; Nagaoka, H

  PLoS One, 2011年12月28日, 査読有り

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• Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

  Maki Kobayashi; Zahra Sabouri; Somayeh Sabouri; Yoko Kitawaki; Yves Pommier; Takaya Abe; Hiroshi Kiyonari; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2011年11月29日, 査読有り

  この論文にアクセスする：

  
• Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

  Okazaki IM(Kyoto; Natsume Tohru(National; Institute of; Advanced Industrial Science; Technology),Iemura Shun-Ichiro(National; Institute of; Advanced Industrial Science; Technology; Honjo Tasuku; Kyoto University; Okawa Katsuya(Kyowa; Hakko Kirin Co; Kobayashi Maki; Kyoto university; Yoshikawa Kiyotsugu(Dana-Farber CancerInstitute; Kawamoto Shimpei(RIKEN Research Center; Nagaoka Hitoshi(Gifu University; Shinkura Reiko(Nagahama; Institute of Bioscience; Technology; Kitawaki Yoko; yo; Taniguchi Hisaaki(University of Tokushim

  Proc Natl Acad Sci U S A, 2011年05月10日, 査読有り

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• Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1

  Fredy R.S. Gutierrez; Flávia S. Mariano; Carlo J.F. Oliveira; Wander R. Pavanelli; Paulo M.M. Guedes; Grace K. Silva; Ana P. Campanelli; Cristiane M. Milanezi; Miyuki Azuma; Tasuku Honjo; Mauro M. Teixeira; Julio C.S. Aliberti; João S. Silva

  Infection and Immunity, 2011年05月, 査読有り

  
• Type I interferon promotes PD-1 transcription and limits the duration of T cell-mediated immunity

  Shunsuke Chikuma; Seigo Terawaki; Shiro Shibayama; Tamon Hayashi; Takao Yoshida; Taku Okazaki; Tasuku Honjo

  JOURNAL OF IMMUNOLOGY, 2011年04月, 査読有り

  
• IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity

  Seigo Terawaki; Shunsuke Chikuma; Shiro Shibayama; Tamon Hayashi; Takao Yoshida; Taku Okazaki; Tasuku Honjo

  Journal of Immunology, 2011年03月01日, 査読有り

  
• Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

  Min Wei; Reiko Shinkura; Yasuko Doi; Mikako Maruya; Sidonia Fagarasan; Tasuku Honjo

  Nature Immunology, 2011年03月, 査読有り

  
• Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis

  Grégory Peignon; Aurélie Durand; Wulfran Cacheux; Olivier Ayrault; Benoît Terris; Pierre Laurent-Puig; Noah F. Shroyer; Isabelle Van Seuningen; Tasuku Honjo; Christine Perret; Béatrice Romagnolo

  Gut, 2011年02月, 査読有り

  
• PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

  Taku Okazaki; Il-Mi Okazaki; Jian Wang; Daisuke Sugiura; Fumio Nakaki; Taku Yoshida; Yu Kato; Sidonia Fagarasan; Masamichi Muramatsu; Tomoo Eto; Kyoji Hioki; Tasuku Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2011年02月, 査読有り

  
• Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

  Andre Stanlie; Masatoshi Aida; Masamichi Muramatsu; Tasuku Honjo; Nasim A. Begum

  Proceedings of the National Academy of Sciences of the United States of America, 2010年12月21日, 査読有り

  この論文にアクセスする：

  
• Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

  Robin Jeannet; Jérôme Mastio; Alejandra Macias-Garcia; Attila Oravecz; Todd Ashworth; Anne-Solen Geimer Le Lay; Bernard Jost; Stéphanie Le Gras; Jacques Ghysdael; Thomas Gridley; Tasuku Honjo; Freddy Radtke; Jon C. Aster; Susan Chan; Philippe Kastner

  Blood, 2010年12月16日, 査読有り

  
• X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells

  Kate L. Jones; Michael Roche; Michael P. Gantier; Nasim A. Begum; Tasuku Honjo; Salvatore Caradonna; Bryan R. G. Williams; Johnson Mak

  Journal of Biological Chemistry, 2010年06月11日, 査読有り

  
• RBPj kappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

  Yufeng Dong; Alana M. Jesse; Anat Kohn; Lea M. Gunnell; Tasuku Honjo; Michael J. Zuscik; Regis J. O'Keefe; Matthew J. Hilton

  DEVELOPMENT, 2010年05月, 査読有り

  
• PD-1 deficiency results in the development of fatal myocarditis in MRL mice

  Jian Wang; Il-Mi Okazaki; Taku Yoshida; Shunsuke Chikuma; Yu Kato; Fumio Nakaki; Hiroshi Hiai; Tasuku Honjo; Taku Okazaki

  International Immunology, 2010年04月21日, 査読有り

  
• Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

  Ryosuke Hino; Kenji Kabashima; Yu Kato; Hiroaki Yagi; Motonobu Nakamura; Tasuku Honjo; Taku Okazaki; Yoshiki Tokura

  Cancer, 2010年04月01日, 査読有り

  
• Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity.

  Nagaoka Hitoshi; Tran Thinh Huy; Kobayashi Maki; Aida Masatoshi; Honjo Tasuku

  International immunology, 2010年04月, 査読有り

  
• Anti-programmed cell death 1 antibody reduces CD4⁺PD-1 ⁺ T cells and relieves the lupus-like nephritis of NZB/W F1 Mice

  Shimpei Kasagi; Seiji Kawano; Taku Okazaki; Tasuku Honjo; Akio Morinobu; Saori Hatachi; Kenichiro Shimatani; Yoshimasa Tanaka; Nagahiro Minato; Shunichi Kumagai

  Journal of Immunology, 2010年03月01日

  
• B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.

  Tran Thinh Huy; Nakata Mikiyo; Suzuki Keiichiro; Begum Nasim A; Shinkura Reiko; Fagarasan Sidonia; Honjo Tasuku; Nagaoka Hitoshi

  Nature immunology, 2010年02月, 査読有り

  
• AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

  Kobayashi M; Aida M; Nagaoka H; Begum NA; Kitawaki Y; Nakata M; Stanlie A; Doi T; Kato L; Okazaki IM; Shinkura R; Muramatsu M; Kinoshita K; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, 2009年12月, 査読有り

  この論文にアクセスする：

  
• AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

  Kobayashi Maki; Aida Masatoshi; Nagaoka Hitoshi; Begum Nasim A; Kitawaki Yoko; Nakata Mikiyo; Stanlie Andre; Doi Tomomitsu; Kato Lucia; Okazaki Il-mi; Shinkura Reiko; Muramatsu Masamichi; Kinoshita Kazuo; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 2009年12月, 査読有り

  
• RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

  Motoaki Fujimoto; Yasushi Takagi; Kazue Muraki; Kazuhiko Nozaki; Norio Yamamoto; Masayuki Tsuji; Nobuo Hashimoto; Tasuku Honjo; Kenji Tanigaki

  Developmental Biology, 2009年08月15日, 査読有り

  
• Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

  Zahra Sabouri; Il-Mi Okazaki; Reiko Shinkura; Nasim Begum; Hitoshi Nagaoka; Daisuke Tsuchimoto; Yusaku Nakabeppu; Tasuku Honjo

  International immunology, 2009年08月, 査読有り

  
• Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

  Sabouri Zahra; Okazaki Il-Mi; Shinkura Reiko; Begum Nasim; Nagaoka Hitoshi; Tsuchimoto Daisuke; Nakabeppu Yusaku; Honjo Tasuku

  International immunology, 2009年08月, 査読有り

  
• PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo

  Shunsuke Chikuma; Seigo Terawaki; Tamon Hayashi; Ryusuke Nabeshima; Takao Yoshida; Shiro Shibayama; Taku Okazaki; Tasuku Honjo

  Journal of Immunology, 2009年06月01日, 査読有り

  
• Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

  Marie Carlén; Konstantinos Meletis; Christian Göritz; Vladimer Darsalia; Emma Evergren; Kenji Tanigaki; Mario Amendola; Fanie Barnabé-Heider; Maggie S. Y. Yeung; Luigi Naldini; Tasuku Honjo; Zaal Kokaia; Oleg Shupliakov; Robert M. Cassidy; Olle Lindvall; Jonas Frisén

  Nature Neuroscience, 2009年03月, 査読有り

  
• Preferential Generation of Follicular B Helper T Cells from Foxp3(+) T Cells in Gut Peyer's Patches

  Masayuki Tsuji; Noriko Komatsu; Shimpei Kawamoto; Keiichiro Suzuki; Osami Kanagawa; Tasuku Honjo; Shohei Hori; Sidonia Fagarasan

  SCIENCE, 2009年03月, 査読有り

  
• Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis

  Yukio Sekiguchi; Motoki Ichikawa; Masaya Takamoto; Hiroyoshi Ota; Chang-Sung Koh; Masamichi Muramatsu; Tasuku Honjo; Kazunaga Agematsu

  Immunology Letters, 2009年02月21日, 査読有り

  
• Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.

  Nonaka T; Doi T; Toyoshima T; Muramatsu M; Honjo T; Kinoshita K

  Proceedings of the National Academy of Sciences of the United States of America, 2009年02月, 査読有り

  
• The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

  Doi T; Kato L; Ito S; Shinkura R; Wei M; Nagaoka H; Wang J; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, 2009年02月, 査読有り

  
• The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

  Doi Tomomitsu; Kato Lucia; Ito Satomi; Shinkura Reiko; Wei Min; Nagaoka Hitoshi; Wang Jishu; Honjo Tasuku

  Proceedings of the National Academy of Sciences of the United States of America, 2009年02月, 査読有り

  
• Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination

  Nasim A. Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2009年02月, 査読有り

  
• A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

  A. Takai; T. Toyoshima; M. Uemura; Y. Kitawaki; H. Marusawa; H. Hiai; S. Yamada; I.M. Okazaki; T. Honjo; T. Chiba; K. Kinoshita

  Oncogene, 2009年01月29日, 査読有り

  
• T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions

  Sunao Sugita; Yoshihiko Usui; Shintaro Horie; Yuri Futagami; Hiroyuki Aburatani; Taku Okazaki; Tasuku Honjo; Masaru Takeuchi; Manabu Mochizuki

  Investigative Ophthalmology and Visual Science, 2009年, 査読有り

  
• Identification of QTLs that modify peripheral neuropathy in NOD. H2b - Pdcd1-/- mice

  Fang Jiang; Taku Yoshida; Fumio Nakaki; Seigo Terawaki; Shunsuke Chikuma; Yu Kato; Il-Mi Okazaki; Tasuku Honjo; Taku Okazaki

  International Immunology, 2009年, 査読有り

  
• Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

  Toshiyuki Morisawa; Hiroyuki Marusawa; Yoshibide Ueda; Akio Iwai; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba

  INTERNATIONAL JOURNAL OF CANCER, 2008年12月, 査読有り

  
• 発癌過程における遺伝子異常の生成へのActivation-induced cytidine deaminase(AID)の関与

  遠藤 容子; 丸澤 宏之; 木下 和生; 本庶 佑; 千葉 勉

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2008年11月

  
• Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants

  Velizar Shivarov; Reiko Shinkura; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2008年10月14日, 査読有り

  
• Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling

  Masahiro Kido; Norihiko Watanabe; Taku Okazaki; Takuji Akamatsu; Junya Tanaka; Kazuyuki Saga; Akiyoshi Nishio; Tasuku Honjo; Tsutomu Chiba

  Gastroenterology, 2008年10月, 査読有り

  
• Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

  Fabienne Haspot; Thomas Fehr; Carrie Gibbons; Guiling Zhao; Timothy Hogan; Tasuku Honjo; Gordon J. Freeman; Megan Sykes

  Blood, 2008年09月01日, 査読有り

  
• Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers

  Y. Endo; H. Marusawa; T. Kou; H. Nakase; S. Fujii; T. Fujimori; K. Kinoshita; T. Honjo; T. Chiba

  Gastroenterology, 2008年09月, 査読有り

  
• A memoir of AID, which engraves antibody memory on DNA

  Tasuku Honjo

  Nature Immunology, 2008年04月, 査読有り

  
• PD-1 deficiency reveals various tissue-specific autoimmunity by H-2 b and dose-dependent requirement of H-2g7 for diabetes in NOD mice

  Taku Yoshida; Fang Jiang; Tasuku Honjo; Taku Okazaki

  Proceedings of the National Academy of Sciences of the United States of America, 2008年03月04日, 査読有り

  
• The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome

  Kathy A. Green; Taku Okazaki; Tasuku Honjo; W. James Cook; William R. Green

  Journal of Virology, 2008年03月, 査読有り

  
• The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

  David Yin Wei Lin; Yoshimasa Tanaka; Masashi Iwasaki; Apostolos G. Gittis; Hua Poo Su; Bunzo Mikami; Taku Okazaki; Tasuku Honjo; Nagahiro Minato; David N. Garboczi

  Proceedings of the National Academy of Sciences of the United States of America, 2008年02月26日

  
• A mouse model for inflammation-associated carcinogenesis in digestive organs; the AID-transgenic mouse

  Toshiyuki Morisawa; Hiroyuki Marusawa; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008年

  
• Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

  Orbicia Riccio; Marielle E. van Gijn; April C. Bezdek; Luca Pellegrinet; Johan H. van Es; Ursula Zimber-Strobl; Lothar J. Strobl; Tasuku Honjo; Hans Clevers; Freddy Radtke

  EMBO Reports, 2008年, 査読有り

  
• AID is required for germinal center-derived lymphomagenesis

  Laura Pasqualucci; Govind Bhagat; Mila Jankovic; Mara Compagno; Paula Smith; Masamichi Muramatsu; Tasuku Honjo; Herbert C. Morse III; Michel C. Nussenzweig; Riccardo Dalla-Favera

  Nature Genetics, 2008年01月, 査読有り

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase (Journal of Biological Chemistry (2006) 281, (19115-19123))

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  Journal of Biological Chemistry, 2008年01月, 査読有り

  
• The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling

  Okiru Komine; Mai Nagaoka; Kei Watase; David H. Gutmann; Kenji Tanigaki; Tasuku Honjo; Freddy Radtke; Toshiki Saito; Shigeru Chiba; Kohichi Tanaka

  Developmental Biology, 2007年11月01日, 査読有り

  
• AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

  Alexander L. Kovalchuk; Wendy Dubois; Elizabeth Mushinski; Nicole E. McNeil; Carsten Hirt; Chen-Feng Qi; Zhaoyang Li; Siegfried Janz; Tasuku Honjo; Masamichi Muramatsu; Thomas Ried; Timothy Behrens; Michael Potter

  JOURNAL OF EXPERIMENTAL MEDICINE, 2007年11月, 査読有り

  
• Multiple roles of Notch signaling in cochlear development.

  Takebayashi S; Yamamoto N; Yabe D; Fukuda H; Kojima K; Ito J; Honjo T

  Developmental biology, 2007年07月01日, 査読有り

  
• Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: Possible application to enhance T cell function

  Seigo Terawaki; Yoshimasa Tanaka; Tomokazu Nagakura; Tamon Hayashi; Shiro Shibayama; Kaori Muroi; Taku Okazaki; Bunzo Mikami; David N. Garboczi; Tasuku Honjo; Nagahiro Minato

  International Immunology, 2007年07月01日

  
• Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.

  Yabe D; Fukuda H; Aoki M; Yamada S; Takebayashi S; Shinkura R; Yamamoto N; Honjo T

  Genesis (New York, N.Y. : 2000), 2007年05月, 査読有り

  
• Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer

  Junzo Hamanishi; Masaki Mandai; Masashi Iwasaki; Taku Okazaki; Yoshimasa Tanaka; Ken Yamaguchi; Toshihiro Higuchi; Haruhiko Yagi; Kenji Takakura; Nagahiro Minato; Tasuku Honjo; Shingo Fujii

  Proceedings of the National Academy of Sciences of the United States of America, 2007年02月27日

  
• AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells

  Kaori Kumazaki; Boaz Tirosh; René Maehr; Marianne Boes; Tasuku Honjo; Hidde L. Ploegh

  Journal of Immunology, 2007年02月15日, 査読有り

  
• Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

  Tsuji M; Shinkura R; Kuroda K; Yabe D; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, 2007年01月03日, 査読有り

  
• Regulation of AID function in vivo

  Reiko Shinkura; Il-Mi Okazaki; Taro Muto; Nasim A. Begum; Tasuku Honjo

  Advances in Experimental Medicine and Biology, 2007年, 査読有り

  
• Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling

  Y. Endo; H. Marusawa; K. Kinoshita; T. Morisawa; T. Sakurai; I.-M. Okazaki; K. Watashi; K. Shimotohno; T. Honjo; T. Chiba

  Oncogene, 2007年, 査読有り

  
• Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

  Y. Matsumoto; H. Marusawa; K. Kinoshita; Y. Endo; T. Kou; T. Morisawa; T. Azuma; I.-M. Okazaki; T. Honjo; T. Chiba

  Nature Medicine, 2007年, 査読有り

  
• Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination

  Nasim A. Begum; Nakako Izumi; Momoko Nishikori; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo

  Journal of Biological Chemistry, 2007年01月, 査読有り

  
• Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

  Ai Kotani; Naoki Kakazu; Tatsuaki Tsuruyama; Il Mi Okazaki; Masamichi Muramatsu; Kazuo Kinoshita; Hitoshi Nagaoka; Daisuke Yabe; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2007年01月, 査読有り

  
• The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

  Shinya Tanaka; Jun Tsukada; Wataru Suzuki; Katsuhiko Hayashi; Kenji Tanigaki; Masayuki Tsuji; Hiromasa Inoue; Tasuku Honjo; Masato Kubo

  Immunity, 2006年06月, 査読有り

  
• The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

  Krista D. Buono; Gertraud W. Robinson; Cyril Martin; Shaolin Shi; Pamela Stanley; Kenji Tanigaki; Tasuku Honjo; Lothar Hennighausen

  Developmental Biology, 2006年05月15日, 査読有り

  
• The 20th IUBMB International Congress in Kyoto

  Koichi Ikuta; Ryoichiro Kageyama; Tasuku Honjo

  IUBMB Life, 2006年05月, 査読有り

  
• Negative regulation of activation-induced cytidine deaminase in B cells

  Taro Muto; Taro Muto; Il Mi Okazaki; Shuichi Yamada; Yoshimasa Tanaka; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2006年02月, 査読有り

  
• Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.

  Yamamoto N; Tanigaki K; Tsuji M; Yabe D; Ito J; Honjo T

  Journal of molecular medicine (Berlin, Germany), 2006年01月, 査読有り

  
• Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas

  Fujikura J; Hosoda K; Iwakura H; Tomita T; Noguchi M; Masuzaki H; Tanigaki K; Yabe D; Honjo T; Nakao K

  Cell Metabolism, 2006年, 査読有り

  
• Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID

  Koshou Wakae; Brad G. Magor; Holly Saunders; Hitoshi Nagaoka; Akemi Kawamura; Kazuo Kinoshita; Tasuku Honjo; Masamichi Muramatsu

  International Immunology, 2006年01月, 査読有り

  
• Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b(-/-)Pdcd1(-/-) mice

  T Okazaki; Y Otaka; J Wang; H Hiai; T Takai; JV Ravetch; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2005年12月, 査読有り

  
• Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome

  Masaya Kobayashi; Seiji Kawano; Saori Hatachi; Chiyo Kurimoto; Taku Okazaki; Yoshiko Iwai; Tasuku Honjo; Yoshimasa Tanaka; Nagahiro Minato; Takahide Komori; Sakan Maeda; Shunichi Kumagai

  The Journal Of Rheumatology, 2005年11月

  
• Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila

  Toshiaki Kikuchi; Sita Andarini; Hong Xin; Kazunori Gomi; Yutaka Tokue; Yasuo Saijo; Tasuku Honjo; Akira Watanabe; Toshihiro Nukiwa

  Infection and Immunity, 2005年09月, 査読有り

  
• Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes

  Jian Wang; Taku Yoshida; Fumio Nakaki; Hiroshi Hiai; Taku Okazaki; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2005年08月16日, 査読有り

  
• AID to overcome the limitations of genomic information

  Tasuku Honjo; Hitoshi Nagaoka; Reiko Shinkura; Masamichi Muramatsu

  Nature Immunology, 2005年07月, 査読有り

  
• Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

  Hong Xin; Toshiaki Kikuchi; Sita Andarini; Shinya Ohkouchi; Takuji Suzuki; Toshihiro Nukiwa; Huqun; Koichi Hagiwara; Tasuku Honjo; Yasuo Saijo

  European Journal of Immunology, 2005年05月, 査読有り

  
• PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

  Yoshiko Iwai; Seigo Terawaki; Tasuku Honjo

  International Immunology, 2005年02月, 査読有り

  
• Two distinctive pathways for recruitment of naive and primed IgM(+) B cells to the gut lamina propria

  K Suzuki; B Meek; Y Doi; T Honjo; S Fagarasan

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005年02月, 査読有り

  
• Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells.

  Kishi Y; Takahashi J; Koyanagi M; Morizane A; Okamoto Y; Horiguchi S; Tashiro K; Honjo T; Fujii S; Hashimoto N

  Journal of neuroscience research, 2005年02月, 査読有り

  
• DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase

  Hitoshi Nagaoka; Satomi Ito; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2005年02月, 査読有り

  
• Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

  Hans Christian Probst; Kathy McCoy; Taku Okazaki; Tasuku Honjo; Maries Van Den Broek

  Nature Immunology, 2005年, 査読有り

  
• AIDによるクラススイッチと体細胞突然変異の制御機構

  新蔵 礼子; 伊藤 聡美; Begum Nasim; 長岡 仁; 村松 正道; 木下 和生; 土方 博子; 本庶 佑

  日本免疫学会総会・学術集会記録, 2004年11月

  
• Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

  Luke T. Krebs; John R. Shutter; Kenji Tanigaki; Tasuku Honjo; Kevin L. Stark; Thomas Gridley

  Genes and Development, 2004年10月15日, 査読有り

  
• Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.

  Michishita M; Ikeda T; Nakashiba T; Ogawa M; Tashiro K; Honjo T; Doi K; Itohara S; Endo S

  Brain research. Developmental brain research, 2004年10月, 査読有り

  
• B1b lymphocytes confer T cell-independent long-lasting immunity

  Kishore R. Alugupalli; John M. Leong; Robert T. Woodland; Masamichi Muramatsu; Tasuku Honjo; Rachel M. Gerstein

  Immunity, 2004年09月, 査読有り

  
• Production of autoantibodies and autoimmune diseases in PD-1 knock-out mice

  OKAZAKI Taku; OTAKA Yumi; WANG Jian; HONJO Tasuku

  日本臨床免疫学会会誌 = Japanese journal of clinical immunology, 2004年08月31日

  
• AID is required for c-myc/IgH chromosome translocations in vivo

  Almudena R. Ramiro; Mila Jankovic; Thomas Eisenreich; Simone Difilippantonio; Selina Chen-Kiang; Masamichi Muramatsu; Tasuku Honjo; André Nussenzweig; Michel C. Nussenzweig

  Cell, 2004年08月20日, 査読有り

  
• De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

  Nasim A. Begum; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2004年08月, 査読有り

  
• PD‐1と自己免疫疾患

  岡崎拓; 本庶佑

  最新医学, 2004年07月10日

  
• Separate domains of AID are required for somatic hypermutation and class-switch recombination

  Reiko Shinkura; Satomi Ito; Nasim A. Begum; Hitoshi Nagaoka; Masamichi Muramatsu; Kazuo Kinoshita; Yishimasa Sakakibara; Hiroko Hijikata; Tasuku Honjo

  Nature Immunology, 2004年07月, 査読有り

  
• Regulation of IgA synthesis at mucosal surfaces

  S Fagarasan; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, 2004年06月, 査読有り

  
• AID: How does it aid antibody diversity?

  T Honjo; M Muramatsu; S Fagarasan

  IMMUNITY, 2004年06月, 査読有り

  
• Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

  Derk Amsen; J. Magarian Blander; Gap Ryol Lee; Kenji Tanigaki; Tasuku Honjo; Richard A. Flavell

  Cell, 2004年05月14日, 査読有り

  
• Regulation of alpha beta/gamma delta, T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

  K Tanigaki; M Tsuji; N Yamamoto; H Han; J Tsukada; H Inoue; M Kubo; T Honjo

  IMMUNITY, 2004年05月, 査読有り

  
• Neural precursor cells derived from human embryonic brain retain regional specificity.

  Horiguchi S; Takahashi J; Kishi Y; Morizane A; Okamoto Y; Koyanagi M; Tsuji M; Tashiro K; Honjo T; Fujii S; Hashimoto N

  Journal of neuroscience research, 2004年03月, 査読有り

  
• Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

  Keiichiro Suzuki; Bob Meek; Yasuko Doi; Masamichi Muramatsu; Tsutomu Chiba; Tasuku Honjo; Sidonia Fagarasan

  Proceedings of the National Academy of Sciences of the United States of America, 2004年02月17日, 査読有り

  
• PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

  Christian Blank; Ian Brown; Amy C. Peterson; Mike Spiotto; Yoshiko Iwai; Tasuku Honjo; Thomas F. Gajewski

  Cancer Research, 2004年02月01日, 査読有り

  
• Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

  Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2004年02月, 査読有り

  
• Unmutated immunoglobulin M can protect mice from death by influenza virus infection

  Yuichi Harada; Masamichi Muramatsu; Toshikatsu Shibata; Tasuku Honjo; Kazufumi Shimizu; Eiko Matsumura; Kazumichi Kuroda

  International Congress Series, 2004年, 査読有り

  
• OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst

  A.T. Nishida; K. Kobuke; K. Kojima; J. Ito; T. Honjo; K. Tashiro

  Developmental Dynamics, 2004年, 査読有り

  
• Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

  Taku Okazaki; Yoshimasa Tanaka; Ryosuke Nishio; Tamotsu Mitsuiye; Akira Mizoguchi; Jian Wang; Masayoshi Ishida; Hiroshi Hiai; Akira Matsumori; Nagahiro Minato; Tasuku Honjo

  Nature Medicine, 2003年12月01日

  
• AID蛋白質量とクラススイッチ組み換え及び体細胞高頻度突然変異効率の解析

  伊藤 聡美; 長岡 仁; 木下 和生; 本庶 佑

  日本免疫学会総会・学術集会記録, 2003年11月

  
• B細胞における体細胞高頻度突然変異はApobec1では誘導されない

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, 2003年11月

  
• RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

  T. Eto; K. Kinoshita; K. Yoshikawa; M. Muramatsu; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 2003年10月28日, 査読有り

  
• Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.

  Toda H; Tsuji M; Nakano I; Kobuke K; Hayashi T; Kasahara H; Takahashi J; Mizoguchi A; Houtani T; Sugimoto T; Hashimoto N; Palmer TD; Honjo T; Tashiro K

  The Journal of biological chemistry, 2003年09月, 査読有り

  
• AID mutant analyses indicate requirement for class-switch-specific cofactors

  Van Thanh Ta; Hitoshi Nagaoka; Nadia Catalan; Anne Durandy; Alain Fischer; Kohsuke Imai; Kohsuke Imai; Shigeaki Nonoyama; Shigeaki Nonoyama; Junko Tashiro; Masaya Ikegawa; Satomi Ito; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo

  Nature Immunology, 2003年09月, 査読有り

  
• PD-1 inhibits antiviral immunity at the effector phase in the liver

  Yoshiko Iwai; Seigo Terawaki; Masaya Ikegawa; Taku Okazaki; Tasuku Honjo

  Journal of Experimental Medicine, 2003年07月07日

  
• A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain.

  Michishita M; Ikeda T; Nakashiba T; Ogawa M; Tashiro K; Honjo T; Doi K; Itohara S; Endo S

  Biochemical and biophysical research communications, 2003年07月, 査読有り

  
• Unmutated immunoglobulin M can protect mice from death by influenza virus infection

  Yuichi Harada; Masamichi Muramatsu; Toshikatsu Shibata; Tasuku Honjo; Kazumichi Kuroda

  Journal of Experimental Medicine, 2003年06月16日, 査読有り

  
• Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.

  Mito Kanatsu-Shinohara; Shinya Toyokuni; Takeshi Morimoto; Shigeyuki Matsui; Tasuku Honjo; Takashi Shinohara

  Biology of reproduction, 2003年05月, 査読有り

  
• Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase

  Yi Zhu; Shigeaki Nonoyama; Tomohiro Morio; Masamichi Muramatsu; Tasuku Honjo; Shuki Mizutani

  Journal of Medical and Dental Sciences, 2003年03月

  
• De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

  T Doi; K Kinoshita; M Ikegawa; M Muramatsu; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003年03月, 査読有り

  
• Molecular Mechanism of Class Switch Recombination

  Janet Stavnezer; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo

  Molecular Biology of B Cells, 2003年02月18日, 査読有り

  
• Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

  K Kuroda; H Han; S Tani; K Tanigaki; T Tun; T Furukawa; Y Taniguchi; H Kurooka; Y Hamada; S Toyokuni; T Honjo

  IMMUNITY, 2003年02月, 査読有り

  
• Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.

  Yamamoto N; Tanigaki K; Han H; Hiai H; Honjo T

  Current biology : CB, 2003年02月, 査読有り

  
• AID Links Class Switching and Somatic Hypermutation

  本庶 佑; Okazaki Ilmi; Yoshikawa Kiyotsugu; Muramatsu Masamichi; Kinoshita Kazuo

  アレルギー, 2003年

  
• Intestinal IgA synthesis: Regulation of front-line body defences

  S Fagarasan; T Honjo

  NATURE REVIEWS IMMUNOLOGY, 2003年01月, 査読有り

  
• New regulatory co-receptors: inducible co-stimulator and PD-1

  T Okazaki; Y Iwai; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, 2002年12月, 査読有り

  
• Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

  Sidonia Fagarasan; Masamichi Muramatsu; Keiichiro Suzuki; Hitoshi Nagaoka; Hiroshi Hiai; Tasuku Honjo

  Science, 2002年11月15日, 査読有り

  
• Microanatomical localization of PD-1 in human tonsils

  Y Iwaia; T Okazaki; H Nishimura; A Kawasaki; H Yagita; T Honjo

  IMMUNOLOGY LETTERS, 2002年10月, 査読有り

  
• Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

  Masayoshi Ishida; Yoshiko Iwai; Yoshimasa Tanaka; Taku Okazaki; Gordon J. Freeman; Nagahiro Minato; Tasuku Honjo

  Immunology Letters, 2002年10月, 査読有り

  
• クラススイッチ刺激によるSmu領域へのAID依存性の点変異

  長岡 仁; 村松 正道; 伊藤 聡美; 木下 和生; 本庶 佑

  日本免疫学会総会・学術集会記録, 2002年10月

  
• Bリンパ球における体細胞高頻度突然変異はクラススイッチ誘導刺激でも誘導される

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 清水 章; 本庶 佑

  日本免疫学会総会・学術集会記録, 2002年10月

  
• AIDは,線維芽細胞中で活発に転写される遺伝子に対して,過剰変異を誘導する

  吉川 清次; 岡崎 一美; 江藤 知憲; 木下 和生; 村松 正道; 長岡 仁; 本庶 佑

  日本免疫学会総会・学術集会記録, 2002年10月

  
• AID-estrogen receptor融合タンパク質AID-ERによる抗体多様化機構の解析

  木下 和生; 土井 知光; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, 2002年10月

  
• Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

  Y Iwai; M Ishida; Y Tanaka; T Okazaki; T Honjo; N Minato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002年09月, 査読有り

  
• AIDは,免疫グロブリン遺伝子H鎖Smu領域に点変異を誘導する

  長岡 仁; 村松 正道; 山村 奈美子; 木下 和生; 本庶 佑

  生化学, 2002年08月

  
• Bリンパ球における体細胞高頻度突然変異はクラススイッチ誘導刺激でも誘導される

  江藤 朋憲; 木下 和生; 吉川 清次; 村松 正道; 清水 章; 本庶 佑

  生化学, 2002年08月

  
• AID-estrogen receptor融合タンパク質AID-ERによる抗体多様化機構の解析

  木下 和生; 土井 知光; 村松 正道; 本庶 佑

  生化学, 2002年08月

  
• DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation

  L Bross; M Muramatsu; K Kinoshita; T Honjo; H Jacobs

  JOURNAL OF EXPERIMENTAL MEDICINE, 2002年05月, 査読有り

  
• Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.

  Tanigaki K; Han H; Yamamoto N; Tashiro K; Ikegawa M; Kuroda K; Suzuki A; Nakano T; Honjo T

  Nature immunology, 2002年05月, 査読有り

  
• Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice.

  Kanatsu-Shinohara M; Ogura A; Ikegawa M; Inoue K; Ogonuki N; Tashiro K; Toyokuni S; Honjo T; Shinohara T

  Proceedings of the National Academy of Sciences of the United States of America, 2002年02月, 査読有り

  
• Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Sμ region: Implication of AID involvement in a common step of class switch recombination and somatic hypermutation

  Hitoshi Nagaoka; Masamichi Muramatsu; Namiko Yamamura; Kazuo Kinoshita; Tasuku Honjo; Tasuku Honjo

  Journal of Experimental Medicine, 2002年02月, 査読有り

  
• Molecular mechanism of class switch recombination: Linkage with somatic hypermutation

  T Honjo; K Kinoshita; M Muramatsu

  ANNUAL REVIEW OF IMMUNOLOGY, 2002年, 査読有り

  
• Fibulin-5/DANCE is essential for elastogenesis in vivo.

  Nakamura T; Lozano PR; Ikeda Y; Iwanaga Y; Hinek A; Minamisawa S; Cheng C; Kobuke K; Dalton N; Takada Y; Tashiro K; Ross Jr. J; Honjo T; Chien KR

  Nature, 2002年01月, 査読有り

  
• AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

  Simone Petersen; Rafael Casellas; Bernardo Reina-San-Martin; Hua Tang Chen; Michael J. Difilippantonio; Patrick C. Wilson; Leif Hanitsch; Arkady Celeste; Masamichi Muramatsu; Duane R. Pilch; Christophe Redon; Thomas Ried; William M. Bonner; Tasuku Honjo; Michel C. Nussenzweig; André Nussenzweig

  Nature, 2001年12月06日, 査読有り

  
• 外来AID強制発現によるAID欠損B細胞のクラススイッチ能の回復

  村松 正道; 木下 和生; 鄭 一美; シドニア・ファガラサン; 本庶 佑

  日本免疫学会総会・学術集会記録, 2001年12月

  
• 新たなクラススイッチ組換えの指標 環状DNAに由来する転写産物の検出

  木下 和生; 張谷 素子; シドニア・ファガラサン; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, 2001年12月

  
• PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

  T Okazaki; A Maeda; H Nishimura; T Kurosaki; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001年11月, 査読有り

  
• Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

  Chen X; Kinoshita K; Honjo T

  Proceedings of the National Academy of Sciences of the United States of America, 2001年11月, 査読有り

  
• A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

  K Kinoshita; M Harigai; S Fagarasan; M Muramatsu; T Honjo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001年10月, 査読有り

  
• ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes,is up-regulated after vascular injury.

  Kobuke, K; Furukawa, Y; Sugai, M; Tanigaki, K; Ohashi, N; Matsumori, A; Sasayama, S; Honjo, T; Tashiro, K

  J. Biol. Chem., 2001年09月, 査読有り

  
• クラススイッチ組換え活性はAID強制発現により線維芽細胞に移入できる

  鄭 一美; 木下 和生; 村松 正道; 本庶 佑

  生化学, 2001年08月

  
• 新たなクラススイッチ組換えの指標 環状DNAに由来する転写産物の検出

  木下 和生; 張谷 素子; Fagarasan Sidonia; 村松 正道; 本庶 佑

  生化学, 2001年08月

  
• レトロウイルスベクターを用いたAID欠損B細胞のスイッチ能の回復

  村松 正道; 木下 和生; 吉川 清次; 榊原 祥公; 鄭 一美; Van Ta; 本庶 佑

  生化学, 2001年08月

  
• Quantitative regulation of class switch recombination by switch region transcription.

  Lee CG; Kinoshita K; Arudchandran A; Cerritelli SM; Crouch RJ; Honjo T

  The Journal of experimental medicine, 2001年08月, 査読有り

  
• Linking class-switch recombination with somatic hypermutation.

  Kinoshita K; Honjo T

  Nature reviews. Molecular cell biology, 2001年07月, 査読有り

  
• Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

  K Hattori; B Heissig; K Tashiro; T Honjo; M Tateno; JH Shieh; NR Hackett; MS Quitoriano; RG Crystal; S Rafii; MAS Moore

  BLOOD, 2001年06月, 査読有り

  
• PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

  H Nishimura; T Honjo

  TRENDS IN IMMUNOLOGY, 2001年05月, 査読有り

  
• Elevated Plasma Stromal Cell-Derived Factor 1 Protein Level in the Progression of HIV Type 1 Infection/AIDS.

  Ikegawa, M; Yuan, J; Matsumoto, K; Herrmann, S; Iwamoto, I; Nakamura, T; Matsushita, S; Kimura, T; Honjo, T; Tashiro, K

  AIDS Research and Human Retroviruses, 2001年05月, 査読有り

  
• Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination

  Y Agata; T Katakai; SK Ye; M Sugai; H Gonda; T Honjo; K Ikuta; A Shimizu

  JOURNAL OF EXPERIMENTAL MEDICINE, 2001年04月, 査読有り

  
• The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription

  S Tani; H Kurooka; T Aoki; N Hashimoto; T Honjo

  NUCLEIC ACIDS RESEARCH, 2001年03月, 査読有り

  
• PD-L2 is a second ligand for PD-1 and inhibits T cell activation

  Yvette Latchman; Clive R. Wood; Tatyana Chernova; Divya Chaudhary; Madhuri Borde; Irene Chernova; Yoshiko Iwai; Andrew J. Long; Julia A. Brown; Raquel Nunes; Edward A. Greenfield; Karen Bourque; Vassiliki A. Boussiotis; Laura L. Carter; Beatriz M. Carreno; Nelly Malenkovich; Hiroyuki Nishimura; Taku Okazaki; Tasuku Honjo; Arlene H. Sharpe; Gordon J. Freeman

  Nature Immunology, 2001年03月, 査読有り

  
• The regulation of PD-1/PD-L1 pathway and autoimmune diseases

  T Okazaki; Y Iwai; H Nishimura; T Honjo

  ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS, 2001年, 査読有り

  
• The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation

  S.-K. Ye; Y. Agata; H.-C. Lee; H. Kurooka; T. Kitamura; A. Shimizu; T. Honjo; K. Ikuta

  Immunity, 2001年, 査読有り

  
• In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

  S. Fagarasan; K. Kinoshita; M. Muramatsu; K. Ikuta; T. Honjo

  Nature, 2001年, 査読有り

  
• Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate.

  Tanigaki, K; Nogaki, F; Takahashi, J; Tashiro, K; Kurooka, H; Honjo, T

  Neuron, 2001年01月, 査読有り

  
• Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Fagarasan; S Yazumi; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2000年12月, 査読有り

  
• アカゲザルにおける低分子化合物(ONO-4007)投与によるSHIV増殖抑制効果

  大倉 定之; 山下 満左裕; 池川 雅哉; 伊吹 謙太郎; 柴山 史朗; 築山 貴美; 松尾 政芳; 田丸 敬次郎; 田代 啓; 本庶 佑

  日本エイズ学会誌, 2000年11月

  
• ヒトActivation-Induced cytidine Deaminase(AID)の単離,発現パターン,染色体位置の同定

  武藤 太郎; 村松 正道; 谷脇 雅史; 木下 和生; Revy Patrick; Durandy Anne; 本庶 佑

  日本免疫学会総会・学術集会記録, 2000年11月

  
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

  GJ Freeman; AJ Long; Y Iwai; K Bourque; T Chernova; H Nishimura; LJ Fitz; N Malenkovich; T Okazaki; MC Byrne; HF Horton; L Fouser; L Carter; Ling, V; MR Bowman; BM Carreno; M Collins; CR Wood; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2000年10月, 査読有り

  
• Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.

  Nakashiba T; Ikeda T; Nishimura S; Tashiro K; Honjo T; Culotti JG; Itohara S

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000年09月, 査読有り

  
• Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA, (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA

  T Kamata; F Nogaki; S Fagarasan; T Sakiyama; N Kobayashi; S Miyawaki; K Ikuta; E Muso; H Yoshida; S Sasayama; T Honjo

  JOURNAL OF IMMUNOLOGY, 2000年08月, 査読有り

  
• クラススイッチ組み換えと体細胞超変異にはRNA校正cytidine deaminaseファミリーの一つである活性化誘導cytidine deaminase(AID)を必要とする

  村松 正道; 木下 和生; Fagarasan Sidonia; 山田 秀一; 真貝 洋一; 本庶 佑

  生化学, 2000年08月

  
• 免疫グロブリンクラススイッチ組み換えはS配列の高次構造を認識する

  田代 純子; 木下 和生; 李 充基; 陳 小川; 本庶 佑

  生化学, 2000年08月

  
• ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mouse.

  Kato, K; Morrison, A. M; Toru, N; Tashiro, K; Honjo, T

  Blood, 2000年07月, 査読有り

  
• Functional interaction between the mouse Notch1 intracellular region and histone acetyltransferases PCAF and GCN5

  K Kurooka; T Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2000年06月, 査読有り

  
• Alymphoplasia (aly)-type Nuclear Factor B-inducing Kinase (NIK) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-associated Lymphatic Tissue System.

  Fagarasan, S; Shinkura, R; Kamata, T; Nogaki, F; Ikuta, K; Tashiro, K; Cyster, G. J; Honjo, T

  J. Exp. Med., 2000年05月, 査読有り

  
• Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice

  H Nishimura; T Honjo; N Minato

  JOURNAL OF EXPERIMENTAL MEDICINE, 2000年03月, 査読有り

  
• Mechanism of B1 cell differentiation and migration in GALT

  S. Fagarasan; R. Shinkura; T. Kamata; F. Nogaki; K. Ikuta; T. Honjo

  Current Topics in Microbiology and Immunology, 2000年, 査読有り

  
• Molecular definition of the autosomal recessive form of the hyper-IgM syndrome

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; A Gennery; H Kayserili; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  IX MEETING OF THE EUROPEAN SOCIETY FOR IMMUNODEFICIENCIES, 2000年, 査読有り

  
• Stormal-derived factor-1 (SDF1) induces TNF-alpha mediated progenitor cell apoptosis of CD34+cells derived from chronic myeloid leukemia (CML).

  Heissig B; Hattori K; Dias S; Tashiro K; Honjo T; Rafii S; Crystal RG; Moore MAS

  BLOOD, 1999年11月15日, 査読有り

  
• 免疫グロブリンクラススイッチ組換えに必要なS配列の解析

  田代 純子; 木下 和生; 李 充基; 陳 小川; 吉川 清次; 村松 正道; 本庶 佑

  日本免疫学会総会・学術集会記録, 1999年10月

  
• 免疫グロブリンクラススイッチ傷害細胞株の解析

  木下 和生; 吉川 清次; 李 充基; 田代 純子; 村松 正道; 陳 小川; 本庶 佑

  生化学, 1999年08月

  
• 日本人正常集団におけるHIV-1耐性遺伝子多型の頻度

  池川 雅哉; 田代 啓; 矢部 大介; 本庶 佑

  生化学, 1999年08月

  
• Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment

  N Watanabe; S Nisitani; K Ikuta; M Suzuki; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 1999年08月, 査読有り

  
• DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.

  Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon NL; Schaub R; Matsumori A; Sasayama S; Chien KR; Honjo T

  The Journal of Biological Chemistry, 1999年08月, 査読有り

  
• Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

  M. Muramatsu; V.S. Sankaranand; S. Anant; M. Sugai; K. Kinoshita; N.O. Davidson; T. Honjo

  Journal of Biological Chemistry, 1999年06月25日, 査読有り

  
• Isoform Specific Expression of the SDR-1 Protein, a and b in Subregions of Adult Rodent Brain.

  Lopez, N.D; Kinoshita, A; Taniwaki, M; Tada, H; Shirozu, M; Nakano, T; Tashiro, K; Honjo, T

  Biomed. Res., 1999年06月

  
• Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.

  Kanazawa N; Nakamura T; Tashiro K; Muramatsu M; Morita K; Yoneda K; Inaba K; Imamura S; Honjo T

  European Journal of Immunology, 1999年06月, 査読有り

  
• Delta-induced notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

  K Kuroda; S Tani; K Tamura; S Minoguchi; H Kurooka; T Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1999年03月, 査読有り

  
• Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L

  Shoichi Tani; Masafumi Taniwaki; Yoshihito Taniguchi; Shigeru Minoguchi; Kazuki Kuroda; Hua Han; Tomokazu Aoki; Shin-Ichi Miyatake; Nobuo Hashimoto; Tasuku Honjo

  Journal of Human Genetics, 1999年, 査読有り

  
• Mechanism of myogenic differentiation suppression by Notch and RBP-J

  H Kurooka; H Kato; Y Taniguchi; S Minoguchi; T Sakai; K Tamura; T Honjo

  NEURAL DEVELOPMENT-BOOK, 1999年, 査読有り

  
• The signal sequence trap method.

  Tashiro K; Nakamura T; Honjo T

  Methods in Enzymology, 1999年, 査読有り

  
• Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region

  H Kurooka; K Kuroda; T Honjo

  NUCLEIC ACIDS RESEARCH, 1998年12月, 査読有り

  
• Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability.

  Nakamura T; Yabe D; Kanazawa N; Tashiro K; Sasayama S; Honjo T

  Genomics, 1998年11月, 査読有り

  
• 免疫グロブリンクラススイッチに伴って発現誘導される新規遺伝子のクローニング

  村松 正道; 木下 和生; 本庶 佑

  日本臨床免疫学会会誌, 1998年10月

  
• 免疫グロブリンクラススイッチ組換えのクラス特異性はS領域により規定されない

  木下 和生; 田代 純子; 李 充基; 本庶 佑

  日本臨床免疫学会会誌, 1998年10月

  
• Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses

  H Nishimura; N Minato; T Nakano; T Honjo

  INTERNATIONAL IMMUNOLOGY, 1998年10月, 査読有り

  
• Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.

  Shioda T; Kato H; Ohnishi Y; Tashiro K; Ikegawa M; Nakayama EE; Hu H; Kato A; Sakai Y; Liu H; Honjo T; Nomoto A; Iwamoto A; Morimoto C; Nagai Y

  Proceedings of the National Academy of Sciences of the United States of America, 1998年05月, 査読有り

  
• Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

  Yabe D; Taniwaki M; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  Genomics, 1998年04月01日, 査読有り

  
• Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

  Yabe D; Taniwaki M; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  Genomics, 1998年04月, 査読有り

  
• Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase

  M Sugai; S Kondo; A Shimizu; T Honjo

  NUCLEIC ACIDS RESEARCH, 1998年02月, 査読有り

  
• LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein

  Y Taniguchi; T Furukawa; T Tun; H Han; T Honjo

  MOLECULAR AND CELLULAR BIOLOGY, 1998年01月, 査読有り

  
• Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.

  Yabe D; Nakamura T; Kanazawa N; Tashiro K; Honjo T

  The Journal of Biological Chemistry, 1997年07月, 査読有り

  
• RBP-L, a transcription factor related to RBP-J kappa

  S Minoguchi; Y Taniguchi; H Kato; T Okazaki; LJ Strobl; U ZimberStrobl; GW Bornkamm; T Honjo

  MOLECULAR AND CELLULAR BIOLOGY, 1997年05月, 査読有り

  
• Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2

  Michael B. Paumen; Yasumasa Ishida; Hua Han; Masamichi Muramatsu; Yutaka Eguchi; Yoshihide Tsujimoto; Tasuku Honjo

  Biochemical and Biophysical Research Communications, 1997年02月24日, 査読有り

  
• Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin

  H Kurooka; K Kato; S Minoguchi; Y Takahashi; J Ikeda; S Habu; N Osawa; AM Buchberg; K Moriwaki; H Shisa; T Honjo

  GENOMICS, 1997年02月, 査読有り

  
• Structure of the mutant fibrillin-1 gene in the tight skin (TSK) mouse

  Constantin A. Bona; Chihiro Murai; Sophia Casares; Kuppuswamy Kasturi; Hiroyuki Nishimura; Tasuku Honjo; Fumihiko Matsuda

  DNA Research, 1997年, 査読有り

  
• Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

  Michael B. Paumen; Yasumasa Ishida; Masamichi Muramatsu; Masaharu Yamamoto; Tasuku Honjo

  Journal of Biological Chemistry, 1997年, 査読有り

  
• Signal Sequence Trap: Expression Cloning Method for Secreted Proteins and Type 1 Membrane Proteins.

  Tashiro, K; Nakano, T; Honjo, T

  Methods in Molecular Biology, 1997年01月, 査読有り

  
• Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.

  Shirozu M; Tada H; Tashiro K; Nakamura T; Lopez ND; Nazarea M; Hamada T; Sato T; Nakano T; Honjo T

  Genomics, 1996年11月, 査読有り

  
• Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.

  Hamada T; Tashiro K; Tada H; Inazawa J; Shirozu M; Shibahara K; Nakamura T; Martina N; Nakano T; Honjo T

  Gene, 1996年10月, 査読有り

  
• Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

  R Shinkura; F Matsuda; T Sakiyama; T Tsubata; H Hiai; M Paumen; S Miyawaki; T Honjo

  INTERNATIONAL IMMUNOLOGY, 1996年07月, 査読有り

  
• Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus

  H Kurooka; JA Segre; Y Hirano; JL Nemhauser; H Nishimura; K Yoneda; ES Lander; T Honjo

  INTERNATIONAL IMMUNOLOGY, 1996年06月, 査読有り

  
• Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: A spontaneous model for Sjogren's syndrome

  Rieko Tsubata; Takeshi Tsubata; Hiroshi Hiai; Reiko Shinkura; Ryutaro Matsumura; Takayuki Sumida; Shigeki Miyawaki; Hiroshi Ishida; Shunichi Kumagai; Kazuwa Nakao; Tasuku Honjo

  European Journal of Immunology, 1996年, 査読有り

  
• Organization of the human immunoglobulin heavy-chain locus

  F Matsuda; T Honjo

  ADVANCES IN IMMUNOLOGY, VOL 62, 1996年, 査読有り

  
• Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes

  Hiroyuki Nishimura; Hiroyuki Nishimura; Yasutoshi Agata; Akemi Kawasaki; Masaki Sato; Sadao Imamura; Nagahiro Minato; Hideo Yagita; Toru Nakano; Tasuku Honjo

  International Immunology, 1996年01月01日

  
• The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.

  Nakamura T; Tashiro K; Nazarea M; Nakano T; Sasayama S; Honjo T

  Genomics, 1995年11月, 査読有り

  
• LOSS OF IMMUNOSTAINING OF THE RBP-J(KAPPA) TRANSCRIPTION FACTOR UPON F9 CELL-DIFFERENTIATION INDUCED BY RETINOIC ACID

  T SAKAI; T FURUKAWA; H IWANARI; C OKA; T NAKANO; M KAWAICHI; T HONJO

  JOURNAL OF BIOCHEMISTRY, 1995年09月, 査読有り

  
• Structure and Chromosomal Localization of the Human Stromal cell-derived factor 1 (SDF1) Gene.

  Shirozu, M; Nakano, T; Inazawa, J; Tashiro, K; Tada, H; Shinohara, T; Honjo, T

  Genomics, 1995年08月

  
• Suppressor of Hairless, the Drosophila homologue of RBP-J.KAPPA., transactivates the neurogenic gene E(spl)m8.

  Furukawa Takahisa; Kobayakawa Yoshitaka; Tamura Kumiko; Kimura Ken-ichi; Kawaichi Masashi; Tanimura Teiichi; Honjo Tasuku

  遺伝学雑誌, 1995年

  
• ショウジョウバエRBP-Jκ遺伝子の成虫末梢神経系の発生におけるニュ-ロジェニックジ-ンとしての作用〔英文〕

  古川 貴久; KIMURA Kenichi; KOBAYAKAWA Yoshitaka; TAMURA Kumiko; KAWAICHI Masashi; TANIMURA Teiichi; HONJO Tasuku

  The Japanese journal of genetics, 1994年12月01日

  
• RECOGNITION SEQUENCE OF A HIGHLY CONSERVED DNA-BINDING PROTEIN RBP-JKAPPA

  T TUN; Y HAMAGUCHI; N MATSUNAMI; T FURUKAWA; T HONJO; M KAWAICHI

  NUCLEIC ACIDS RESEARCH, 1994年03月

  
• Transforming growth factor-β induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation

  T. Iwasato; Y. Kanari; A. Shimizu; T. Honjo; H. Yamagishi

  Immunology Letters, 1994年, 査読有り

  
• DIVERSIFICATION, NOT USE, OF THE IMMUNOGLOBULIN-VH GENE REPERTOIRE IS RESTRICTED IN DIGEORGE-SYNDROME

  RN HAIRE; RD BUELL; RT LITMAN; Y OHTA; SM FU; T HONJO; F MATSUDA; M DELAMORENA; J CARRO; RA GOOD; GW LITMAN

  JOURNAL OF EXPERIMENTAL MEDICINE, 1993年09月, 査読有り

  
• CLONING OF A HUMAN-IMMUNOGLOBULIN GENE FRAGMENT CONTAINING BOTH V(H)-D AND D-J(H) REARRANGEMENTS - IMPLICATION FOR V(H)-D AS AN INTERMEDIATE TO V(H)-D-J(H) FORMATION

  EK SHIN; F MATSUDA; J FUJIKURA; T AKAMIZU; H SUGAWA; T MORI; T HONJO

  EUROPEAN JOURNAL OF IMMUNOLOGY, 1993年09月, 査読有り

  
• HUMAN-JK RECOMBINATION SIGNAL BINDING-PROTEIN GENE (IGKJRB) - COMPARISON WITH ITS MOUSE HOMOLOG

  R AMAKAWA; W JING; K OZAWA; N MATSUNAMI; Y HAMAGUCHI; F MATSUDA; M KAWAICHI; T HONJO

  GENOMICS, 1993年08月, 査読有り

  
• The human Sμbp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin μ chain switch region

  Y. Fukita; T.-R. Mizuta; M. Shirozu; K. Ozawa; A. Shimizu; T. Honjo

  Journal of Biological Chemistry, 1993年08月, 査読有り

  
• Isolation of cDNA encoding a binding protein specific to 5′-phosphorylated single-stranded DNA with G-rich sequences

  T.-R. Mizuta; Y. Fukita; T. Miyoshi; A. Shimizu; T. Honjo

  Nucleic Acids Research, 1993年04月, 査読有り

  
• The complete murine immunoglobulin class switch region of the α heavy chain gene-hierarchic repetitive structure and recombination breakpoints

  H. Arakawa; T. Iwasato; H. Hayashida; A. Shimizu; T. Honjo; H. Yamagishi

  Journal of Biological Chemistry, 1993年03月, 査読有り

  
• Synthesis and regulation of trans-mRNA encoding the immunoglobulin ∈ heavy chain

  A. Shimizu; T. Honjo

  FASEB Journal, 1993年01月, 査読有り

  
• BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF THE DNA-BINDING PROTEIN (RBP-J-KAPPA) TO MOUSE J-KAPPA RECOMBINATION SIGNAL SEQUENCE

  Y HAMAGUCHI; Y YAMAMOTO; H IWANARI; S MARUYAMA; T FURUKAWA; N MATSUNAMI; T HONJO

  JOURNAL OF BIOCHEMISTRY, 1992年09月, 査読有り

  
• Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide

  T. Iwasato; H. Arakawa; A. Shimizu; T. Honjo; H. Yamagishi

  Journal of Experimental Medicine, 1992年06月, 査読有り

  
• EXPRESSION OF MURINE INTERLEUKIN-7 IN A MURINE GLIOMA CELL-LINE RESULTS IN REDUCED TUMORIGENICITY INVIVO

  T AOKI; K TASHIRO; S MIYATAKE; T KINASHI; T NAKANO; Y ODA; H KIKUCHI; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992年05月

  
• MAPPING OF THE NU-GENE USING CONGENIC NUDE STRAINS AND INSITU HYBRIDIZATION

  Y TAKAHASHI; A SHIMIZU; T SAKAI; Y ENDO; N OSAWA; H SHISA; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1992年03月, 査読有り

  
• A TRANSGENIC MODEL OF AUTOIMMUNE HEMOLYTIC-ANEMIA

  M OKAMOTO; M MURAKAMI; A SHIMIZU; S OZAKI; T TSUBATA; S KUMAGAI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1992年01月, 査読有り

  
• THE DROSOPHILA RBP-J-KAPPA GENE ENCODES THE BINDING-PROTEIN FOR THE IMMUNOGLOBULIN J-KAPPA RECOMBINATION SIGNAL SEQUENCE

  T FURUKAWA; M KAWAICHI; N MATSUNAMI; H RYO; Y NISHIDA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1991年12月, 査読有り

  
• Expression of the RAG-2 Gene in Murine Central Nervous System Tumor Cell Lines.

  Aoki, T; Tashiro, K; Miyatake, S; Nakano, T; Oda, Y; Kikuchi, H; Honjo, T

  Biochem. Biophys. Res. Commun, 1991年11月

  
• Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene

  A. Shimizu; M.C. Nussenzweig; H. Han; M. Sanchez; T. Honjo

  Journal of Experimental Medicine, 1991年06月, 査読有り

  
• Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines.

  Tashiro, K; Kinashi, T; Anderson, S. J; Lee, K. H; Tohyama, K; Ogawa, M; Takahashi, M; Kawaichi, M; Honjo, T

  Immunol. Lett., 1991年05月

  
• Different Stromal Cell Lines Support Lineage-selective Differentiation of the Multipotential Bone Marrow Stem Cell Clone LyD9.

  Lee, K. H; Kinashi, T; Tohyama, K; Tashiro, K; Funato, N; Hama, K; Honjo, T

  J. Exp. Med., 1991年05月

  
• Premature Expression of the Macrophage Colony-stimulating Factor Receptor on a Multipotential Stem Cell Line Does Not Alter Differentiation Lineages Controlled by Stromal Cells Used for Coculture.

  Kinashi, T; Lee, K. H; Ogawa, M; Tohyama, K; Tashiro, K; Fukunaga, R; Nagata, S; Honjo, T

  J. Exp. Med., 1991年05月

  
• The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor α subunit mRNA by p27rex

  Kenneth N. White; Tetsuya Nosaka; Hiroshi Kanamori; Masakazu Hatanaka; Tasuku Honjo

  Biochemical and Biophysical Research Communications, 1991年02月

  
• Shared partners in receptors

  Tasuku Honjo

  Current Biology, 1991年, 査読有り

  
• Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells

  T.-R. Mizuta; N. Suzuki; A. Shimizu; T. Honjo

  Journal of Biological Chemistry, 1991年, 査読有り

  
• Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic μ chain and constant regions of endogenous isotypes

  H. Han; M. Okamoto; T. Honjo; A. Shimizu

  International Immunology, 1991年, 査読有り

  
• The membrane exons of the pseudo-γ-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the γ1 gene

  K. Kinoshita; A. Shimizu; T. Honjo

  Immunology Letters, 1991年, 査読有り

  
• Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin

  K. Kuze; A. Shimizu; T. Honjo

  International Immunology, 1991年, 査読有り

  
• HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.

  H Kanamori; N Suzuki; H Siomi; T Nosaka; A Sato; H Sabe; M Hatanaka; T Honjo

  The EMBO Journal, 1990年12月, 査読有り

  
• MALIGNANT TRANSFORMATION OF AN INTERLEUKIN-5-DEPENDENT HEMATOPOIETIC-CELL CLONE BY AUTOCRINE SECRETION OF INTERLEUKIN-5

  K TOHYAMA; KH LEE; K TASHIRO; T KINASHI; T HONJO

  ACTA HAEMATOLOGICA JAPONICA, 1990年12月, 査読有り

  
• ESTABLISHMENT OF AN INTERLEUKIN-5-DEPENDENT SUBCLONE FROM AN INTERLEUKIN-3-DEPENDENT MURINE HEMATOPOIETIC PROGENITOR-CELL LINE, LYD9, AND ITS MALIGNANT TRANSFORMATION BY AUTOCRINE SECRETION OF INTERLEUKIN-5

  K TOHYAMA; KH LEE; K TASHIRO; T KINASHI; T HONJO

  EMBO JOURNAL, 1990年06月

  
• Growth factors involved in lymphocyte differentiation.

  Kinashi, T; Tashiro, K; Lee, K. H; Inaba, K; Tohyama, K; Palacios, R; Honjo, T

  Phil. Trans. R. Soc. Lond. B. Biol. Sci., 1990年05月

  
• Ohno,H., Furukawa,T., Fukuhara,S., Zong,S-.Q., Kamesaki,H., Shows,T., Le Beau,B., McKeithan,T., Kawakami,T. and Honjo,T. Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1・・・

  OHNO H; FURUKAWA T; FUKUHARA S; ZONG S Q; KAMESAKI H; SHOWS T B; LE BEAU M M; MCKEITHAN T W; HONJO T

  Proc. Natl. Acad. Sci. USA, 1990年01月

  
• Why are multiple chains required for the interleukin 2 receptor?

  Yuji Saito; Tasuku Honjo

  Progress in Growth Factor Research, 1990年, 査読有り

  
• IMMUNOGLOBULIN DOUBLE ISOTYPE EXPRESSION BY TRANS-MESSENGER RNA IN A HUMAN MU-CHAIN TRANSGENIC MOUSE

  A SHIMIZU; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  RECOMBINANT SYSTEMS IN PROTEIN EXPRESSION, 1990年, 査読有り

  
• Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

  P. Sideras; T.-R. Mizuta; H. Kanamori; N. Suzuki; M. Okamoto; K. Kuze; H. Ohno; S. Doi; S. Fukuhara; M.S. Hassan; L. Hammarstrom; E. Smith; A. Shimizu; T. Honjo

  International Immunology, 1989年11月, 査読有り

  
• MULTIPLE EFFECTS OF HUMAN RECOMBINANT INTERLEUKIN-4 ON HUMAN MYELOID MONOCYTE CELL-LINES

  T NOMA; H NAKAKUBO; K HAMA; T HONJO

  IMMUNOLOGY LETTERS, 1989年06月, 査読有り

  
• T-CELLS FROM EOSINOPHILIC PATIENTS PRODUCE INTERLEUKIN-5 WITH INTERLEUKIN-2 STIMULATION

  H ENOKIHARA; S FURUSAWA; H NAKAKUBO; H KAJITANI; S NAGASHIMA; K SAITO; H SHISHIDO; Y HITOSHI; K TAKATSU; T NOMA; A SHIMIZU; T HONJO

  BLOOD, 1989年05月, 査読有り

  
• STRUCTURE AND FUNCTION OF LYMPHOKINES AND THEIR RECEPTORS

  A SHIMIZU; T KINASHI; Y ISHIDA; T HONJO

  PROGRESS IN IMMUNOLOGY, VOL 7, 1989年, 査読有り

  
• MOLECULAR MECHANISM FOR IMMUNOGLOBULIN DOUBLE-ISOTYPE EXPRESSION

  A SHIMIZU; T KINASHI; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989年, 査読有り

  
• MOLECULAR MECHANISM FOR IMMUNOGLOBULIN DOUBLE-ISOTYPE EXPRESSION

  A SHIMIZU; T KINASHI; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989年, 査読有り

  
• Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse

  A. Shimizu; M. C. Nussenzweig; T. R. Mizuta; P. Leder; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1989年01月, 査読有り

  
• Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related

  T. Noma; H. Nakakubo; M. Sugita; S. Kumagi; M. Maeda; A. Shimizu; T. Honjo

  Journal of Experimental Medicine, 1989年, 査読有り

  
• Effect of human recombinant interleukin 4 on in vitro granulopoiesis of human bone marrow cells

  Hiroshi Kajitani; Hideo Enokihara; Satoshi Tsunogake; Naoto Takano; Kenji Saito; Shimpei Furusawa; Hideo Shishido; Takafumi Noma; Akira Shimizu; Tasuku Honjo

  Growth Factors, 1989年01月01日

  
• An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes

  T. Kinashi; K. Tashiro; K. Inaba; T. Takeda; R. Palacios; T. Honjo

  International Immunology, 1989年, 査読有り

  
• Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor  and  genes.

  Inaba, K; Inaba, M; Kinashi, T; Tashiro, K; Witmer-Pack, M; Crowley, M; Kaplan, G; Valinsky, J; Romani, N; Ikehara, S; Muramatsu, S; Honjo, T; Steinman, R.M

  J. Exp. Med., 1988年12月

  
• BIASED EXPRESSION OF VARIABLE REGION GENE FAMILIES OF THE IMMUNOGLOBULIN HEAVY-CHAIN IN AUTOIMMUNE-PRONE MICE

  Y YAOITA; M TAKAHASHI; C AZUMA; Y KANAI; T HONJO

  JOURNAL OF BIOCHEMISTRY, 1988年09月, 査読有り

  
• Application of a human T cell line derived from a Sezary syndrome patient for human interleukin 4 assay

  Michiyuki Maeda; Takafumi Noma; Kazuaki Hama; Tasuku Honjo

  Immunology letters, 1988年08月, 査読有り

  
• PHYSICAL LINKAGE OF A VARIABLE REGION SEGMENT AND THE JOINING REGION SEGMENT OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  T SATO; F MATSUDA; HL KWANG; KS EUY; T HONJO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988年07月, 査読有り

  
• Differentiation of a precursor cell with the germline context immunoglobulin gene into immunoglobulin-producing cells in vitro.

  Kinashi, T; Inaba, K; Tsubata, T; Tashiro, K; Palacios, R; Honjo, T

  Ann. N. Y. Acad. Sci., 1988年06月, 査読有り

  
• Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cell in vitro.

  Kinashi, T; Inaba, K; Tsubata, T; Tashiro, K; Palacios, R; Honjo, T

  Proc. Natl. Acad. Sci. U. S. A., 1988年06月

  
• Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation

  Hideo Enokihara; Shigeki Nagasima; Takafumi Noma; Hiroshi Kajitani; Hiroyuki Hamaguchi; Kenji Saito; Shimpei Furusawa; Hideo Shishido; Tasuku Honjo

  Immunology letters, 1988年05月, 査読有り

  
• HUMAN IMMUNOGLOBULIN-D SEGMENTS - ISOLATION OF A NEW D-SEGMENT AND POLYMORPHIC DELETION OF THE D1-SEGMENT

  SQ ZONG; S NAKAI; F MATSUDA; KH LEE; T HONJO

  IMMUNOLOGY LETTERS, 1988年04月, 査読有り

  
• DISPERSED LOCALIZATION OF D-SEGMENTS IN THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; KH LEE; S NAKAI; T SATO; M KODAIRA; SQ ZONG; H OHNO; S FUKUHARA; T HONJO

  EMBO JOURNAL, 1988年04月, 査読有り

  
• Both B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line

  Kenji Nakanishi; Tomohiro Yoshimoto; Yoshiya Katoh; Shiro Ono; Kiyoshi Matsui; Keisai Hiroishi; Takafumi Noma; Tasuku Honjo; Kiyoshi Takatsu; Kazuya Higashino; Toshiyuki Hamaoka

  The Journal of Immunology, 1988年02月, 査読有り

  
• Introduction and expression of the interleukin 2 receptor (tac) gene in hematopoietic stem cells with retrovirus vectors

  Shun-Ichi Takeda; Yasushi Hamaguchi; Shu Qin Zong; Kogo Kuze; Tasuku Honjo; Minoru Ishimoto; Toru Nakano; Yukihiko Kitamura

  Growth Factors, 1988年, 査読有り

  
• MULTIPLE RECOMBINATIONAL EVENTS IN PRIMATE IMMUNOGLOBULIN EPSILON-GENES AND ALPHA-GENES SUGGEST CLOSER RELATIONSHIP OF HUMANS TO CHIMPANZEES THAN TO GORILLAS

  S UEDA; F MATSUDA; T HONJO

  JOURNAL OF MOLECULAR EVOLUTION, 1988年, 査読有り

  
• A soluble \\'anchorminus\\' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses

  N. Kondo; S. Kondo; A. Shimizu; T. Honjo; J. Hamuro

  Immunology Letters, 1988年, 査読有り

  
• Molecular cloning and structure of the mouse interleukin-5 gene

  Tatsunobu-Ryushin Mizuta; Toshizumi Tanabe; Hiroshi Nakakubo; Takafumi Noma; Tasuku Honjo

  Growth factors, 1988年, 査読有り

  
• Fibroblast-dependent growth of mouse mast cells in vitro: Duplication of mast cell depletion in mutant mice of W/W(v) genotype

  J. Fujita; H. Nakayama; H. Onoue; Y. Kanakura; T. Nakano; H. Asai; S.-I. Takeda; T. Honjo; Y. Kitamura

  Journal of Cellular Physiology, 1988年01月, 査読有り

  
• MOLECULAR-CLONING AND STRUCTURE OF THE HUMAN INTERLEUKIN-5 GENE

  T TANABE; M KONISHI; T MIZUTA; T NOMA; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1987年12月, 査読有り

  
• Nucleotide sequences of variable region segments of the immunoglobulin heavy chain of Xenopus laevis

  Yuriko Yamawaki-Kataoka; Tasuku Honjo

  Nucleic Acids Research, 1987年07月24日, 査読有り

  
• HUMAN NEOPLASTIC B-CELLS EXPRESS MORE THAN 2 ISOTYPES OF IMMUNOGLOBULINS WITHOUT DELETION OF HEAVY-CHAIN CONSTANT-REGION GENES

  T KINASHI; T GODAL; Y NOMA; NR LING; Y YAOITA; T HONJO

  GENES & DEVELOPMENT, 1987年07月, 査読有り

  
• TRANSCRIPTION OF IL-2 RECEPTOR GENE IS STIMULATED BY ATL-DERIVED FACTOR PRODUCED BY HTLV-I(+) T-CELL LINES

  Y TAGAYA; Y TANIGUCHI; M NARAMURA; M OKADA; N SUZUKI; H KANAMORI; T NIKAIDO; T HONJO; J YODOI

  IMMUNOLOGY LETTERS, 1987年07月, 査読有り

  
• ENHANCEMENT OF THE INTERLEUKIN-2 RECEPTOR EXPRESSION ON T-CELLS BY MULTIPLE B-LYMPHOTROPIC LYMPHOKINES

  T NOMA; T MIZUTA; A ROSEN; T HIRANO; T KISHIMOTO; T HONJO

  IMMUNOLOGY LETTERS, 1987年07月, 査読有り

  
• A NOVEL FAMILY OF VARIABLE REGION GENES OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN

  KH LEE; F MATSUDA; T KINASHI; M KODAIRA; T HONJO

  JOURNAL OF MOLECULAR BIOLOGY, 1987年06月, 査読有り

  
• EXPRESSION AND FUNCTIONAL-CHARACTERIZATION OF ARTIFICIAL MUTANTS OF INTERLEUKIN-2 RECEPTOR

  S KONDO; M KINOSHITA; A SHIMIZU; Y SAITO; M KONISHI; H SABE; T HONJO

  NATURE, 1987年05月, 査読有り

  
• Structure and Function of Interleukins 4 and 5

  Tasuku Honjo; Yoshio Yaoita; Tatsuo Kinashi; Yoshihiko Noma; Takayuki Naito; Chihiro Azuma; Eva Severinson; Paschalis Sideras; Susanna Bergstedt‐Lindqvist; Kiyoshi Takatsu; Akira Tominaga; Nobuhiko Harada; Toshizumi Tanabe; Mikio Konishi; Masazumi Takahashi; Fumihiko Matsuda

  Pediatrics International, 1987年, 査読有り

  
• RELATIONSHIP OF HUMAN CORD BLOOD MONONUCLEAR CELL-LINES, ESTABLISHED BY THE HTLV-I INTEGRATION, TO EXPRESSION OF T-CELL PHENOTYPES AND THE T-CELL RECEPTOR GENE REARRANGEMENT

  H MIWA; T UCHIDA; T KOBAYASHI; K KITA; S SHIRAKAWA; Y KOYANAGI; N YAMAMOTO; A SHIMIZU; T HONJO; M HATANAKA

  JOURNAL OF MOLECULAR AND CELLULAR IMMUNOLOGY, 1987年, 査読有り

  
• CLONING OF CDNA FOR HUMAN T-CELL REPLACING FACTOR (INTERLEUKIN-5) AND COMPARISON WITH THE MURINE HOMOLOG

  C AZUMA; T TANABE; M KONISHI; T KINASHI; T NOMA; F MATSUDA; Y YAOITA; K TAKATSU; L HAMMARSTROM; CIE SMITH; E SEVERINSON; T HONJO

  NUCLEIC ACIDS RESEARCH, 1986年11月, 査読有り

  
• A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the β-chain gene of the human T-cell receptor

  K. Ikuta; T. Ogura; A. Shimizu; T. Honjo

  Nucleic Acids Research, 1986年06月, 査読有り

  
• Expression of functional human interleukin-2 receptor in mice T cells by cDNA transfection

  S. Kondo; A. Shimizu; M. Maeda; Y. Tagaya; J. Yodoi; T. Honjo

  Nature, 1986年03月, 査読有り

  
• INTERLEUKIN-2 RECEPTOR - STRUCTURE, FUNCTION, AND EXPRESSION

  H KANAMORI; S KONDO; M KINOSHITA; N SUZUKI; Y SAITO; H SABE; N MATSUNAMI; N ISHIDA; A SHIMIZU; T HONJO

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986年

  
• Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines

  K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato

  Journal of Experimental Medicine, 1986年, 査読有り

  
• Organization and evolution of variable region genes of the human immunoglobulin heavy chain.

  Kodaira, M; Kinashi, T; Umemura, I; Matsuda, F; Noma, T; Ono, Y; Honjo, T

  J. Mol. Biol., 1986年, 査読有り

  
• Rat Lymphoid Cell Lines Producing Human T Cell Leukemia Virus.

  淀井 淳司; Masafumi Okada; Yutaka Tagaya; Keisuke Teshigawara; 福井 清; 石田 直理雄; 生田 宏一; 前田 道之; 本庶 佑; Hisao Osawa; Tibor Diamantstein; Masatoshi Tateno; Takashi Yoshiki

  The Journal of Experimental Medicine, 1985年05月, 査読有り

  
• Low frequency of somatic mutation in β-chain variable region genes of human T-cell receptors

  K. Ikuta; T. Ogura; A. Shimizu; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1985年, 査読有り

  
• II-2 receptor genes

  N. Ishida; T. Nikaido; S. Kondo; S. Takeda; A. Shimizu; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 1985年, 査読有り

  
• Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence

  A. Shimuzu; S. Kondo; S.-I. Takeda; J. Yodoi; N. Ishida; H. Sabe; H. Osawa; T. Diamantstein; T. Nikaido; T. Honjo

  Nucleic Acids Research, 1985年, 査読有り

  
• Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences

  S. Takeda; T. Naito; K. Hama; T. Noma; T. Honjo

  Nature, 1985年, 査読有り

  
• TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)

  J. Yodoi; K. Teshigawara; T. Nikaido; K. Fukui; T. Noma; T. Honjo; M. Takigawa; M. Sasaki; N. Minato; M. Tsudo

  Journal of Immunology, 1985年, 査読有り

  
• Molecular cloning and structure of the human interleukin 2 receptor gene

  N. Ishida; H. Kanamori; T. Noma; T. Nikaido; H. Sabe; N. Suzuki; A. Shimizu; T. Honjo

  Nucleic Acids Research, 1985年, 査読有り

  
• Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement

  M. Maeda; A. Shimizu; K. Ikuta; H. Okamoto; M. Kashihara; T. Uchiyama; T. Honjo; J. Yodoi

  Journal of Experimental Medicine, 1985年, 査読有り

  
• Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection

  Hisataka Sabe; Shigeru Kondo; Akira Shimizu; Yutaka Tagaya; Junji Yodoi; Nobuyuki Kobayashi; Masakazu Hatanaka; Norisada Matsunami; Michiyuki Maeda; Takafumi Noma; Tasuku Honjo

  Molecular Biology & Medicine, 1984年12月, 査読有り

  
• Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region

  Naoki Takahashi; Takafumi Noma; Tasuku Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1984年08月, 査読有り

  
• Genomic structure of HTLV (human T-cell leukemia virus): detection of defective genome and its amplification in MT-2 cells

  Nobuyuki Kobayashi; Hiroshi Konishi; Hisataka Sabe; Katsuya Shigesada; Takafumi Noma; Tasuku Honjo; Masakazu Hatanaka

  The EMBO Journal, 1984年06月, 査読有り

  
• DUPLICATED IMMUNOGLOBULIN GAMMA-2A GENES IN WILD MICE

  K FUKUI; Y HAMAGUCHI; A SHIMIZU; S NAKAI; K MORIWAKI; CH WANG; T HONJO

  JOURNAL OF MOLECULAR AND CELLULAR IMMUNOLOGY, 1984年, 査読有り

  
• Origin of Adult T-Cell Leukemia Virus

  福井 清; 野間 隆文; Kaoru Takeuchi; Nobuyuki Kobayashi; 畑中 正一; 本庶 佑

  Molecular Biology & Medicine, 1983年11月, 査読有り

  
• RECONSTITUTION OF ANTIGEN-SPECIFIC SUPPRESSOR ACTIVITY WITH TRANSLATION PRODUCTS OF MESSENGER-RNA

  M TANIGUCHI; T TOKUHISA; M KANNO; Y YAOITA; A SHIMIZU; T HONJO

  NATURE, 1982年, 査読有り

  
• LONG TERMINAL REPEAT-LIKE ELEMENTS FLANK A HUMAN-IMMUNOGLOBULIN EPSILON PSEUDOGENE THAT LACKS INTRONS

  S UEDA; S NAKAI; Y NISHIDA; H HISAJIMA; T HONJO

  EMBO JOURNAL, 1982年, 査読有り

  
• EXPRESSION OF LYMPHOCYTE SURFACE IGE DOES NOT REQUIRE SWITCH RECOMBINATION

  Y YAOITA; Y KUMAGAI; K OKUMURA; T HONJO

  NATURE, 1982年, 査読有り

  
• Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes

  A. Shimizu; Y. Hamaguchi; Y. Yaoita; K. Moriwaki; K. Kondo; T. Honjo

  Nature, 1982年, 査読有り

  
• Structure of a rearranged γ1 chain gene and its implication to immunoglobulin class-switch mechanism

  M. Obata; T. Kataoka; S. Nakai; H. Yamagishi; N. Takahashi; Y. Yamawaki-Kataoka; T. Nikaido; A. Shimizu; T. Honjo

  Proceedings of the National Academy of Sciences of the United States of America, 1981年, 査読有り

  
• DELETION OF IMMUNOGLOBULIN HEAVY-CHAIN GENES ACCOMPANIES THE CLASS SWITCH REARRANGEMENT

  Y YAOITA; T HONJO

  BIOMEDICAL RESEARCH-TOKYO, 1980年, 査読有り

  
• DELETION OF IMMUNOGLOBULIN HEAVY-CHAIN GENES FROM EXPRESSED ALLELIC CHROMOSOME

  Y YAOITA; T HONJO

  NATURE, 1980年, 査読有り

  
• Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes: Evidence for recent reshuffling

  Ryusuke Matsumura; Fumihiko Matsuda; Hitoshi Nagaoka; Junji Fujikura; Euy Kyun Shin; Euy Kyun Shin; Yosho Fukita; Yosho Fukita; Makoto Haino; Tasuku Honjo; Tasuku Honjo; Tasuku Honjo

  Journal of Immunology

  
• Recent Translocation of Variable and Diversity Segments of the Human Immunoglobulin Heavy Chain from Chromosome 14 to Chromosomes 15 and 16

  Hitoshi Nagaoka; Kazuo Ozawa; Fumihiko Matsuda; Hidenori Hayashida; Ryusuke Matsumura; Makoto Haino; Euy Kyun Shin; Yosho Fukita; Takashi Imai; Rakesh Anand; Kazushige Yokoyama; Toshihiko Eki; Eiichi Soeda; Tasuku Honjo

  Genomics

  
• Physical map of the 3′ region of the human immunoglobulin heavy chain locus: Clustering of autoantibody-related variable segments in one haplotype

  Euy Kyun Shin; Fumihiko Matsuda; Hitoshi Nagaoka; Yosho Fukita; Takashi Imai; Kazushige Yokoyama; Eiichi Soeda; Tasuku Honjo; Tasuku Honjo

  EMBO Journal

  
• Organization of variable region segments of the human immunoglobulin heavy chain: Duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments

  Fumihiko Matsuda; Euy Kyun Shin; Yasuhiko Hirabayashi; Hitoshi Nagaoka; Michihiro C. Yoshida; Michihiro C. Yoshida; Shu Quin Zong; Tasuku Honjo

  EMBO Journal

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  Journal of Biological Chemistry

  
• Comparison and Evolution of Human Immunoglobulin VH Segments Located in the 3′ 0.8-Megabase Region: Evidence for Unidirectional Transfer of Segmental Gene Sequences

  Makoto Haino; Hidenori Hayashida; Takashi Miyata; Euy Kyun Shin; Fumihiko Matsuda; Hitoshi Nagaoka; Ryusuke Matsumura; Shigeo Taka-ishi; Yosho Fukita; Junji Fujikura; Tasuku Honjo; Tasuku Honjo

  Journal of Biological Chemistry

  
• Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

  Zahra Sabouri; Il mi Okazaki; Il mi Okazaki; Reiko Shinkura; Nasim Begum; Hitoshi Nagaoka; Tasuku Honjo

  International Immunology

  
• AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model

  Y. Komeno; Y. Komeno; J. Kitaura; J. Kitaura; N. Watanabe-Okochi; N. Watanabe-Okochi; N. Kato; N. Kato; T. Oki; T. Oki; F. Nakahara; F. Nakahara; Y. Harada; H. Harada; R. Shinkura; H. Nagaoka; Y. Hayashi; T. Honjo; T. Kitamura; T. Kitamura

  Leukemia

  
• Uracil DNA glycosylase activity is dispensable for immunloglobulin class switch

  NA Begum; K Kinoshita; N Kakazu; M Muramatsu; H Nagaoka; R Shinkura; D Biniszkiewicz; LA Boyer; R Jaenisch; T Honjo

  SCIENCE, 2004年08月

  
• Constitutive expression of AID leads to tumorigenesis

  Okazaki, I; H Hiai; N Kakazu; S Yamada; M Muramatsu; K Kinoshita; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2003年05月

  
• The AID enzyme induces class switch recombination in fibroblasts.

  IM Okazaki

  NATURE REVIEWS IMMUNOLOGY, 2002年05月

  
• AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

  K Yoshikawa; IM Okazaki; T Eto; K Kinoshita; M Muramatsu; H Nagaoka; T Honjo

  SCIENCE, 2002年06月

  
• Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

  H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo

  SCIENCE, 2001年01月

  
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

  M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo

  CELL, 2000年09月

  
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Lagelouse; A Gennery; Tezcan, I; F Ersoy; H Kayserili; AG Ugazio; N Brousse; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  CELL, 2000年09月

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  H Kato; Y Taniguchi; H Kurooka; S Minoguchi; T Sakai; S NomuraOkazaki; K Tamura; T Honjo

  DEVELOPMENT, 1997年10月

  
• Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice

  M Murakami; K Nakajima; K Yamazaki; T Muraguchi; T Serikawa; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 1997年02月

  
• Conservation of the Notch signalling pathway in mammalian neurogenesis

  J delaPompa; A Wakeham; KM Correia; E Samper; S Brown; RJ Aguilera; T Nakano; T Honjo; TW Mak; J Rossant; RA Conlon

  DEVELOPMENT, 1997年03月

  
• The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor

  T Honjo

  GENES TO CELLS, 1996年01月

  
• In vitro development of primitive and definitive erythrocytes from different precursors

  T Nakano; H Kodama; T Honjo

  SCIENCE, 1996年05月

  
• Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor.

  本庶 佑

  Current Biology,5/,1416, 1995年

  
• DISRUPTION OF THE MOUSE RBP-J-KAPPA GENE RESULTS IN EARLY EMBRYONIC DEATH

  C OKA; T NAKANO; A WAKEHAM; JL DELAPOMPA; C MORI; T SAKAI; S OKAZAKI; M KAWAICHI; K SHIOTA; TW MAK; T HONJO

  DEVELOPMENT, 1995年10月

  
• ORAL-ADMINISTRATION OF LIPOPOLYSACCHARIDES ACTIVATES B-1 CELLS IN THE PERITONEAL-CAVITY AND LAMINA PROPRIA OF THE GUT AND INDUCES AUTOIMMUNE SYMPTOMS IN AN AUTOANTIBODY TRANSGENIC MOUSE

  M MURAKAMI; T TSUBATA; R SHINKURA; S NISITANI; M OKAMOTO; H YOSHIOKA; T USUI; S MIYAWAKI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1994年07月

  
• GENERATION OF LYMPHOHEMATOPOIETIC CELLS FROM EMBRYONIC STEM-CELLS IN CULTURE

  T NAKANO; H KODAMA; T HONJO

  SCIENCE, 1994年08月

  
• EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 EXERTS ITS TRANSACTIVATING FUNCTION THROUGH INTERACTION WITH RECOMBINATION SIGNAL BINDING-PROTEIN RBP-J-KAPPA, THE HOMOLOG OF DROSOPHILA SUPPRESSOR OF HAIRLESS (VOL 13, PG 4973, 1994)

  U ZIMBERSTROBL; LJ STROBL; C MEITINGER; R HINRICHS; T SAKAI; T FURUKAWA; T HONJO; G BORNKAMM

  EMBO JOURNAL, 1994年12月

  
• ANTIGEN-RECEPTOR CROSS-LINKING INDUCES PERITONEAL B-CELL APOPTOSIS IN NORMAL BUT NOT AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; T HONJO

  CURRENT BIOLOGY, 1994年01月

  
• THE BCL-2 GENE-PRODUCT INHIBITS CLONAL DELETION OF SELF-REACTIVE B-LYMPHOCYTES IN THE PERIPHERY BUT NOT IN THE BONE-MARROW

  S NISITANI; T TSUBATA; M MURAKAMI; M OKAMOTO; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1993年10月

  
• STRUCTURE AND PHYSICAL MAP OF 64 VARIABLE SEGMENTS IN THE 3(I)0.8-MEGABASE REGION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; Y FUKITA; S TAKAISHI; T IMAI; JH RILEY; R ANAND; E SOEDA; T HONJO

  NATURE GENETICS, 1993年01月

  
• SIGNAL SEQUENCE TRAP - A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE-I MEMBRANE-PROTEINS

  K TASHIRO; H TADA; R HEILKER; M SHIROZU; T NAKANO; T HONJO

  SCIENCE, 1993年07月

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY A T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  NATURE, 1993年08月

  
• ANTIGEN-INDUCED APOPTOTIC DEATH OF LY-1 B-CELLS RESPONSIBLE FOR AUTOIMMUNE-DISEASE IN TRANSGENIC MICE

  M MURAKAMI; T TSUBATA; M OKAMOTO; A SHIMIZU; S KUMAGAI; H IMURA; T HONJO

  NATURE, 1992年05月

  
• A PROTEIN-BINDING TO THE J-KAPPA RECOMBINATION SEQUENCE OF IMMUNOGLOBULIN GENES CONTAINS A SEQUENCE RELATED TO THE INTEGRASE MOTIF

  N MATSUNAMI; Y HAMAGUCHI; Y YAMAMOTO; K KUZE; K KANGAWA; H MATSUO; M KAWAICHI; T HONJO

  NATURE, 1989年12月

  
• CLONING OF COMPLEMENTARY-DNA ENCODING T-CELL REPLACING FACTOR AND IDENTITY WITH B-CELL GROWTH FACTOR-II

  T KINASHI; N HARADA; E SEVERINSON; T TANABE; P SIDERAS; M KONISHI; C AZUMA; A TOMINAGA; S BERGSTEDTLINDQVIST; M TAKAHASHI; F MATSUDA; Y YAOITA; K TAKATSU; T HONJO

  NATURE, 1986年11月

  
• CLONING OF CDNA-ENCODING THE MURINE IGG1 INDUCTION FACTOR BY A NOVEL STRATEGY USING SP6 PROMOTER

  Y NOMA; P SIDERAS; T NAITO; S BERGSTEDTLINDQUIST; C AZUMA; E SEVERINSON; T TANABE; T KINASHI; F MATSUDA; Y YAOITA; T HONJO

  NATURE, 1986年02月

  
• MOLECULAR-CLONING AND EXPRESSION OF CDNAS ENCODING THE HUMAN INTERLEUKIN-2 RECEPTOR

  WJ LEONARD; JM DEPPER; GR CRABTREE; S RUDIKOFF; J PUMPHREY; RJ ROBB; M KRONKE; PB SVETLIK; NJ PEFFER; TA WALDMANN; WC GREENE

  LYMPHOKINE RESEARCH, 1984年

  
• IMMUNOGLOBULIN CLASS SWITCHING

  A SHIMIZU; T HONJO

  CELL, 1984年

  
• IMMUNOGLOBULIN GENES

  T HONJO

  ANNUAL REVIEW OF IMMUNOLOGY, 1983年

  
• SWITCH REGION OF IMMUNOGLOBULIN C-MU-GENE IS COMPOSED OF SIMPLE TANDEM REPETITIVE SEQUENCES

  T NIKAIDO; S NAKAI; T HONJO

  NATURE, 1981年

  
• Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination

  本庶 佑

  Cell 18,559-568,18, 1979年

  
• Organization of immnoglobulin heavy chain genes and allelic deletion model

  本庶 佑

  Proceeding of National Academy of Science 75,2140-2144,75, 1978年

  

MISC

• Transcriptional activity of EBNA2 through RBP-J

  T. Sakai; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 1997年

  
• Activation-induced cytidine deaminase(AID)による免疫記憶形成に必要なAgo2-miRNA依存的なtopoisomerase1(Top1)の調節機構

  小林牧; 若栗浩幸; 清水正和; 日笠幸一郎; 松田文彦; 本庶佑

  日本分子生物学会年会プログラム・要旨集(Web), 2023年

  
• Ago2とmiRNAはAID依存性の抗体遺伝子組換えにおけるDNA切断を促進するためにDNAトポイソメラーゼ1を減少させる

  小林牧; 若栗浩幸; 清水正和; 日笠幸一郎; 松田文彦; 本庶佑

  日本生化学会大会(Web), 2023年

  
• B細胞発生におけるRBP-Jの機能

  谷垣 健二; 山本 典生; 本庶 佑

  日本免疫学会総会・学術集会記録, 2001年12月

  
• 血漿交換療法と細胞療法 免疫抑制受容体PD-1と自己免疫疾患

  岡崎 拓; 田中 義正; 岩井 佳子; 西村 泰行; 松森 昭; 湊 長博; 本庶 佑

  リウマチ, 2001年04月

  
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

  GJ Freeman; AJ Long; Y Iwai; Y Latchman; K Bourque; JA Brown; VA Boussiotis; DM Dorfman; T Chernova; H Nishimura; L Fitz; N Malenkovich; T Okazaki; M Byrne; H Horton; L Fouser; L Carter; AH Sharpe; B Carreno; M Collins; CR Wood; T Honjo

  BLOOD, 2000年11月

  
• The B7-homologue, PD-L, is the ligand of the PD-1 immunoinhibitory receptor

  GJ Freeman; AJ Long; Y Iwai; K Bourque; T Chernova; H Nishimura; L Fitz; N Malenkovich; T Okazaki; M Byrne; H Horton; L Fouser; L Carter; B Carreno; M Collins; CR Wood; T Honjo

  FASEB JOURNAL, 2000年04月

  
• 抗ヒトPD-1モノクローナル抗体作製とヒトPBMCにおけるPD-1発現の解析

  岩井 佳子; 川崎 明美; 八木田 秀雄; 西村 泰行; 本庶 佑

  生化学, 1999年08月

  
• REPETITIVE SEQUENCES IN CLASS-SWITCH RECOMBINATION REGIONS OF IMMUNOGLOBULIN HEAVY-CHAIN GENES

  T KATAOKA; T MIYATA; T HONJO

  CELL, 1981年

  
• DERMATOLOGICAL AND IMMUNOLOGICAL ABNORMALITIES IN HUMAN IL-2 AND IL-2/IL-2 RECEPTOR L-CHAIN TRANSGENIC MICE

  Y ISHIDA; M NISHI; O TAGUCHI; K INABA; N MINATO; M KAWAICHI; T HONJO

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989年03月

  
• 免疫応答の多様性を支えるしくみ T細胞抗原受容体の多様性発現機構

  生田 宏一; 本庶 佑

  化学と生物, 1986年01月

  
• CLONING OF HUMAN IMMUNOGLOBULIN-EPSILON CHAIN GENES - EVIDENCE FOR MULTIPLE C-EPSILON GENES

  Y NISHIDA; T MIKI; H HISAJIMA; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982年

  
• CLONING OF MOUSE IMMUNOGLOBULIN-EPSILON GENE AND ITS LOCATION WITHIN THE HEAVY-CHAIN GENE-CLUSTER

  Y NISHIDA; T KATAOKA; N ISHIDA; S NAKAI; T KISHIMOTO; BOTTCHER, I; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981年

  
• 切除可能非小細胞肺癌II-IIIA期における可溶性免疫因子の検討(WJOG12319LTR)

  谷崎 潤子; 黒田 浩章; 横山 俊秀; 高濱 誠; 庄田 浩康; 中村 敦; 北村 嘉隆; 豆鞘 伸昭; 門田 嘉久; 光岡 茂樹; 沖塩 協一; 岡田 守人; 坂井 和子; 千葉 康敬; 西尾 和人; 茶本 健司; 本庶 佑; 山本 信之; 中川 和彦; 林 秀敏

  肺癌, 2022年11月

  
• Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.

  Ryusuke Hatae; Kenji Chamoto; Young Hak Kim; Kazuhiro Sonomura; Kei Taneishi; Shuji Kawaguchi; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Maryam Akrami; Sidonia Fagarasan; Izuru Masuda; Yasushi Okuno; Fumihiko Matsuda; Toyohiro Hirai; Tasuku Honjo

  JCI insight, 2020年01月30日

  このMISCにアクセスする：

  
• The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR

  Maki Kobayashi; Misao Takemoto; Tasuku Honjo

  DNA Repair, 2017年05月01日

  
• Cancer immunotherapies targeting the PD-1 signaling pathway

  Yoshiko Iwai; Junzo Hamanishi; Kenji Chamoto; Tasuku Honjo

  JOURNAL OF BIOMEDICAL SCIENCE, 2017年04月

  このMISCにアクセスする：

  
• トポイソメラーゼ1を介したAIDによる免疫グロブリン遺伝子の多様化

  小林 牧; 若栗 浩幸; 清水 正和; 日笠 幸一郎; 松田 文彦; 本庶 佑

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月

  
• Activation-induced cytidine deaminase promotes oncogenesis of ultraviolet light-independent epidermal cancer from keratinocytic and melanocytic origin

  T. Nonaka; M. Uemura; H. Hiai; N. Minato; T. Honjo; K. Kinoshita

  FEBS JOURNAL, 2012年09月

  
• An evolutionary view of the mechanism for immune and genome diversity

  Lucia Kato; Andre Stanlie; Nasim A. Begum; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo

  Journal of Immunology, 2012年04月15日

  
• Two Opposing roles of RBP-J in Notch signaling

  Kenji Tanigaki; Tasuku Honjo

  Current Topics in Developmental Biology, 2010年

  
• B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

  Honjo Tasuku; Nagaoka Hitoshi; Tran Thinh Huy; Nakata Mikiyo; Suzuki Keiichiro; Begum Nasim A; Shinkura Reiko; Fagarasan Sidonia

  Nature Immunology, 2009年12月06日

  このMISCにアクセスする：

  
• AID遺伝子(Aicda)の発現は,刺激反応性及びBリンパ球特異的な2つのエンハンサー領域とそれに拮抗するサイレンサーにより制御される。

  TRAN Thinh Huy; 長岡仁; 中田幹代; BEGUM Nasim A; 新藏礼子; 本庶佑

  生化学, 2009年09月25日

  
• Involvement of IFN-gamma producing CD4(+) PD-1(+) T cells in lupus-prone NZB/W f1 mice

  Shimpei Kasagi; Seiji Kawano; Akio Morinobu; Saori Hatachi; Taku Okazaki; Yoshimasa Tanaka; Nagahiro Minato; Tasuku Honjo; Shunichi Kumagai

  ARTHRITIS AND RHEUMATISM, 2008年09月

  
• Identification of a specific domain required for dimerization of activation-induced cytidine deaminase (Retraction of vol 281, pg 19115, 2006)

  Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2008年01月

  
• PD-1 and PD-1 ligands: From discovery to clinical application

  Taku Okazaki; Tasuku Honjo

  International Immunology, 2007年07月

  
• Regulation of lymphocyte development by Notch signaling

  Kenji Tanigaki; Tasuku Honjo

  Nature Immunology, 2007年05月

  
• Ectopic expression of activation-induced cytidine deaminase in ulcerative colitis-associated colorectal cancers

  Tadayuki Kou; Hiroyuki Marusawa; Yoko Endo; Hiroshi Nakase; Shigehiko Fujii; Kazuo Kinoshita; Takahiro Fujimori; Tasuku Honjo; Tsutomu Chiba

  GASTROENTEROLOGY, 2007年04月

  
• High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis

  Junji Komori; Hiroyuki Marusawa; Takafumi Machimoto; Yoko Endo; Kazuo Kinoshita; Tadayuki Kou; Hironori Haga; Iwao Ikai; Shinji Uemoto; Tasuku Honjo; Tsutomu Chiba

  GASTROENTEROLOGY, 2007年04月

  
• Notchシグナルによる細胞分化制御:シグナルの不活化と過剰活性化を可能にする2種類の遺伝子欠損マウスの比較解析からわかったこと

  矢部大介; 福田仁; 青木節代; 竹林慎治; 山本典生; 本庶佑

  日本薬学会年会要旨集, 2007年03月05日

  
• Role of AID in Tumorigenesis

  Il-mi Okazaki; Ai Kotani; Tasuku Honjo

  Advances in Immunology, 2007年

  
• The PD-1-PD-L pathway in immunological tolerance

  T Okazaki; T Honjo

  TRENDS IN IMMUNOLOGY, 2006年04月

  
• Rejuvenating exhausted T cells during chronic viral infection

  T Okazaki; T Honjo

  CELL, 2006年02月

  
• In search of the best grant system

  Tasuku Honjo

  Science, 2005年08月26日

  
• Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy

  T Okazaki; T Honjo

  TRENDS IN MOLECULAR MEDICINE, 2005年07月

  
• AID欠失マウスにおける(4-ヒドロキシ-3-ニトロフェニル)アセチルハプテンに対する免疫応答のダイナミズム

  SHIMIZU Takeyuki; OSAKO Mina; MURAKAMI Akikazu; MURAMATSU Masamichi; HONJO Tasuku; AZUMA Takachika

  日本免疫学会総会・学術集会記録, 2005年

  
• Emu-cmycトランスジェニックマウスに発症するB細胞リンパ腫におけるAIDの関与の検討

  幸谷愛; 嘉数直樹; 鶴山竜昭; 岡崎一美; 村松正道; 本庶佑

  臨床血液, 2005年

  
• A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.

  Kotani A; Okazaki I; Muramatsu M; Kinoshita K; Begum N; Nakajima T; Saito H; Honjo T

  Proc. Natl. Acad. Sci. USA., 2005年

  
• Notchシグナルを負に制御する因子Mintによる神経発生の制御

  福田仁; 矢部大介; 山田秀一; 辻正幸; 竹林慎治; 山本典生; 新蔵礼子; 高橋淳; 橋本信夫; 真貝洋一; 本庶佑

  日本脳神経外科学会総会抄録集(CD-ROM), 2005年

  
• Response to comment on "uracil DNA glycosylase activity is dispensable for immunoglobulin class switch"

  NA Begum; T Honjo

  SCIENCE, 2004年12月

  
• T細胞分化におけるMINTの機能解析

  辻正幸; 新蔵礼子; 矢部大介; 山本典生; 本庶佑

  日本免疫学会総会・学術集会記録, 2004年11月05日

  
• 臨床応用を目的とした可溶性PD-1組換え蛋白の大量精製と抗腫瘍効果の検討

  寺脇 正剛; 田中 義正; 石田 昌義; 岡崎 拓; 江 芳; 湊 長博; 本庶 佑

  日本免疫学会総会・学術集会記録, 2004年11月

  
• The role of autoantibodies against cardiac troponin I in autoimmune dilated cardiomyopathy

  R Nishio; A Matsumori; T Okazaki; Y Tanaka; T Mitsuiye; A Mizoguchi; H Hiai; N Minato; T Honjo

  JOURNAL OF CARDIAC FAILURE, 2004年08月

  
• AIDトランスジェニックマウスにおけるsomatic hypermutationターゲットの検討

  幸谷愛; 岡崎一美; 村松正道; 木下和生; 本庶佑

  臨床血液, 2004年

  
• Domain organization of activation-induced cytidine deaminase (multiple letters)

  Jolanta Zaim; Andrzej M. Kierzek; Van-Thanh Ta; Tasuku Honjo

  Nature Immunology, 2003年12月

  
• AIDによる抗体分子多様化のメカニズム (特集 免疫学研究)

  岡崎 一美; 村松 正道; 本庶 佑

  学術月報, 2003年10月

  
• Preface

  Tasuku Honjo; Frederick Alt; Michael Neuberger

  Molecular Biology of B Cells, 2003年02月18日

  
• Molecular Biology of B Cells

  Tasuku Honjo; Frederick Alt; Michael Neuberger

  Molecular Biology of B Cells, 2003年02月18日

  
• エイズ制御のための基礎研究 HIV感染症の病態と免疫 平成11年度 サルにおけるSDF‐1発現系の作製と新たなCXCR4アンタゴニストの探索 平成12年度 ヒト脳由来神経系幹細胞株の分化誘導系によるHIVウイルス標的細胞の同定 平成13年度 新たなHIV‐1ウイルス感染標的細胞としてのヒト脳由来神経系幹細胞の解析

  田代啓; 大倉定之; 山下満左広; 速水正憲; 柴山史朗; 池川雅哉; 本庶佑; 高橋淳; 堀口聡士

  エイズ制御のための基礎研究 平成10-13年度, 2003年

  
• 細胞傷害性T細胞におけるPD‐1/PD‐L1システムを介した活性抑制制御機構の解析

  石田昌義; 岩井佳子; 田中義正; 岡崎拓; 本庶佑; 湊長博

  日本免疫学会総会・学術集会記録, 2002年10月31日

  
• 脳特異的に発現するBTCL1/2cDNA解析

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本神経科学大会プログラム・抄録集, 2002年07月07日

  
• 膜タンパク質をコードする脳特異的遺伝子BTCL2 cDNAの解析

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本獣医学会学術集会講演要旨集, 2002年03月01日

  
• Human genetic defects in class-switch recombination (hyper-IgM syndromes)

  A Durandy; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, 2001年10月

  
• 脳特異的に発現する膜型タンパク質をコードする新規遺伝子の単離

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  日本神経科学大会プログラム・抄録集, 2001年09月26日

  
• 脳特異的に発現する膜型タンパク質をコードする新規遺伝子の単離

  道下正貴; 池田敏男; 仲柴俊昭; 田代啓; 本庶佑; 土井邦雄; 糸原重美; 遠藤昌吾

  神経化学, 2001年09月01日

  
• HIV‐1感染者血中SDF‐1タンパク濃度の上昇とAIDS発症との関連について

  池川雅哉; えん景利; 松本和子; 岩本愛吉; 中村哲也; 松下修三; 木村哲也; 本庶佑; 田代啓

  生化学, 2001年08月25日

  
• ESOP‐1タンパクの細胞培養液からの精製と機能解析

  田代啓; 池川雅哉; MORRISON A M; 加藤桂三; 仲野徹; 本庶佑

  生化学, 2001年08月25日

  
• 神経幹細胞より単離された分泌タンパク質SDNSFの神経系前駆細胞生存支持活性の解析

  辻 正幸; 戸田 弘紀; 三國 貴康; 高橋 淳; 田代 啓; 本庶 佑

  生化学, 2001年08月

  
• マウス及びヒトにおけるPD-1及びPD-L1発現の組織学的解析

  岩井 佳子; 岡崎 拓; 田中 義正; 川崎 明美; 八木田 秀雄; 湊 長博; 本庶 佑

  生化学, 2001年08月

  
• Palindromic but not G-rich sequences are targets of class switch recombination

  J Tashiro; K Kinoshita; T Honjo

  INTERNATIONAL IMMUNOLOGY, 2001年04月

  
• Complex layers of genetic alteration in the generation of antibody diversity

  M Muramatsu; T Honjo

  TRENDS IN IMMUNOLOGY, 2001年02月

  
• 低分子化合物,ONO‐4007のin vitro抗HIV/SHIV増殖抑制効果

  池川雅哉; 柴山史朗; 山下満左裕; 大倉定之; 松尾政芳; 芳賀久典; 多田秀明; 田代啓; 本庶佑

  日本エイズ学会誌, 2000年11月20日

  
• SDF‐1を産生するSIVの作成

  肖勇; 桑田岳夫; 宇賀神秀樹; 池川雅哉; 田代啓; 本庶佑; 速水正憲

  日本エイズ学会誌, 2000年11月20日

  
• 免疫抑制受容体PD-1のリガンドの単離とその意義

  岩井 佳子; 岡崎 拓; 西村 泰行; 本庶 佑

  日本免疫学会総会・学術集会記録, 2000年11月

  
• SDF-1発現組換えアデノウイルス投与マウスを用いたin vivo SDF-1遊走活性の定量的考察

  池川 雅哉; 田代 啓; 三國 貴康; 本庶 佑

  日本免疫学会総会・学術集会記録, 2000年11月

  
• T-independent immune response: New aspects of B cell biology

  S Fagarasan; T Honjo

  SCIENCE, 2000年10月

  
• SDF‐1のin vivo CXCR4 down modulationおよびchemoattractant活性の定量的考察

  池川雅哉; 田代啓; 松本和子; 本庶佑

  生化学, 2000年08月25日

  
• 免疫抑制受容体PD-1のリガンドの単離とその意義

  岩井 佳子; 西村 泰行; 岡崎 拓; 本庶 佑

  生化学, 2000年08月

  
• Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

  T Muto; M Muramatsu; M Taniwaki; K Kinoshita; T Honjo

  GENOMICS, 2000年08月

  
• Differentiation and migration of B1 cells in GALT

  S Fagarasan; R Shinkura; T Kamata; F Nogaki; K Ikuta; T Honjo

  FASEB JOURNAL, 2000年04月

  
• A germinal center specific gene, AID promotes isotype switching in a mouse B cell lymphoma cells.

  M Muramatsu; K Kinoshita; NO Davidson; Y Shinkai; T Honjo

  FASEB JOURNAL, 2000年04月

  
• Unique and unprecedented recombination mechanisms in class switching - Commentary

  K Kinoshita; T Honjo

  CURRENT OPINION IN IMMUNOLOGY, 2000年04月

  
• Identification of a stimulus-dependent DNase I hypersensitive site between the I alpha and C alpha exons during immunoglobulin heavy chain class switch recombination

  SJ Ono; G Zhou; AKF Tai; M Inaba; K Kinoshita; T Honjo

  FEBS LETTERS, 2000年02月

  
• B cell tolerance and autoimmunity

  T. Tsubata; T. Honjo

  Reviews in Immunogenetics, 2000年

  
• Generation, expansion, migration and activation of mouse B1 cells

  S. Fagarasan; N. Watanabe; T. Honjo

  Immunological Reviews, 2000年

  
• 時間蛍光分解法を応用いた高感度血中SDF‐1測定法の開発

  池川雅哉; 田代啓; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, 1999年11月22日

  
• The human immunoglobulin V-H locus

  F Matsuda; T Honjo

  IMMUNOLOGIST, 1999年11月

  
• SDF-1発現組換えアデノウイルス投与によるCXCR4 down modulation

  池川 雅哉; 田代 啓; 三國 貴康; 斉藤 泉; 鐘ヶ江 裕美; 本庶 佑

  日本免疫学会総会・学術集会記録, 1999年10月

  
• Notchシグナル活性化の分子機構:タンパク質プロセシングの重要性 (特集 Notchシグナリングの新展開--発生現象解明への鍵)

  黒岡 尚徳; 本庶 佑

  細胞工学, 1999年09月

  
• Induction of germline transcription in the TCR gamma locus by Stat5: Implications for accessibility control by the IL-7 receptor

  SK Ye; K Maki; T Kitamura; S Sunaga; K Akashi; J Domen; IL Weissman; T Honjo; K Ikuta

  IMMUNITY, 1999年08月

  
• Constitutive expression of CX3C chemokine fractalkine in mouse skin

  N Kanazawa; K Yoneda; K Tashiro; K Inaba; Y Miyachi; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999年04月

  
• HIV-1耐性遺伝子の研究

  田代啓; 池川雅哉; 矢部大介; 本庶佑

  日本臨牀, 1999年04月, 招待有り

  
• Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region (vol 26, pg 5448, 1998)

  H Kurooka; K Kuroda; T Honjo

  NUCLEIC ACIDS RESEARCH, 1999年03月

  
• Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants

  K. Tashiro; M. Ikegawa; D. Yabe; T. Honjo

  Nippon rinsho. Japanese journal of clinical medicine, 1999年01月01日

  
• NotchシグナルはRBP-Jを介しMyoDの発現及び筋芽細胞の分化を抑制する

  黒田 一樹; 黒岡 尚徳; 本庶 佑

  日本分子生物学会年会プログラム・講演要旨集, 1998年12月01日

  
• Notch細胞質領域/RBP-J複合体による転写活性化の分子機構

  黒岡 尚徳; 黒田 一樹; 本庶 佑

  日本分子生物学会年会プログラム・講演要旨集, 1998年12月01日

  
• 免疫グロブリンクラスイッチ組換えのクラス特異性はS領域により規定されない

  田代 純子; 木下 和生; 李 充基; 本庶 佑

  日本分子生物学会年会プログラム・講演要旨集, 1998年12月01日

  
• 免疫グロブリンクラススイッチに伴って発現誘導される新規遺伝子のクローニング

  村松正道; 菅井学; 木下和生; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, 1998年11月

  
• Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2

  T Sakai; Y Taniguchi; K Tamura; S Minoguchi; T Fukuhara; LJ Strobl; U Zimber-Strobl; GW Bornkamm; T Honjo

  JOURNAL OF VIROLOGY, 1998年07月

  
• Identification of a new class of chemokine expressed in murine dendritic cells by the signal sequence trap method.

  N Kanazawa; T Nakamura; K Tashiro; K Morita; K Yoneda; K Inaba; S Imamura; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998年04月

  
• PD-1 regulates self-tolerance to prevent tissue destruction.

  H Nishimura; H Hiai; N Minato; T Honjo

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998年04月

  
• Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector

  Chikaya Moriya; Tatsuo Shioda; Kei Tashiro; Takashi Nagasawa; Masaya Ikegawa; Yukano Ohnishi; Atsushi Kato; Huiling Hu; Xiaomi Xin; Mohammad K. Hasan; Midori Maekawa; Yutaka Takebe; Yuko Sakai; Tasuku Honjo; Yoshiyuki Nagai

  FEBS Letters, 1998年03月20日

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  KATO Hisamune; TANIGUCHI Yoshihito; KUROOKA Hisanori; MINOGUCHI Shigeru; TAMURA Kumiko; HONJO Tasuku

  Keio journal of medicine, 1997年12月01日

  
• 抗SDF‐1抗体作製とSDF‐1タンパク質解析

  田代啓; 池川雅哉; 矢部大介; 谷垣健二; 中野伊知郎; 中むら智之; 小夫家和宏; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, 1997年12月

  
• Molecular cloning and characterization of a novel cytokine obtained from the murine embryonic heart

  T Nakamura; D Yabe; T Honjo

  CIRCULATION, 1997年10月

  
• シグナル・シークエンス・トラップ法を用いたマウス胎仔期心臓からの新たな小胞体カルシウム結合蛋白（calumenin）のクローニングとその解析

  矢部大介; 中邨智之; 金澤伸雄; 田代啓; 篠山重威; 本庶佑

  心筋の構造と代謝, 1997年, 招待有り

  
• Molecular cloning and expression of a novel FK506-binding protein in murine embryonic heart by the signal sequence trap method

  T Nakamura; D Yabe; T Shioi; Y Furukawa; T Nakano; T Honjo

  CIRCULATION, 1996年10月

  
• Functional conservation of mouse Notch receptor family members

  H Kato; T Sakai; K Tamura; S Minoguchi; Y Shirayoshi; Y Hamada; Y Tsujimoto; T Honjo

  FEBS LETTERS, 1996年10月

  
• Carnitine palmitoyltransferase I protects from apoptosis mediated by de novo synthesis of ceramide

  PAUMEN Michael; MURAMATSU Masamichi; HONJO Tasuku

  日本分子生物学会年会プログラム・講演要旨集, 1996年08月01日

  
• 転写因子RBP-Jkと結合する新しい蛋白質の解析

  谷口 善仁; 古川 貴久; TUN Tir; 本庶 佑

  日本分子生物学会年会プログラム・講演要旨集, 1996年08月01日

  
• Differential development of primitive and definitive erythrocytes culture.

  T Nakano; H Kodama; T Honjo

  EXPERIMENTAL HEMATOLOGY, 1996年08月

  
• 免疫グロブリンクラススイッチの分子機構解明へのアプローチ

  菅井学; 近藤滋; 中村元信; 木下和生; 西山英児; 本庶佑

  日本分子生物学会年会プログラム・講演要旨集, 1996年07月

  
• Disruption of the mouse RBP-J(kappa) gene results in early embryonic death (vol 121, pg 3291, 1995)

  C Oka; T Nakano; A Wakeham; JL delaPompa; C Mori; T Sakai; S Okazaki; M Kawaichi; K Shiota; TW Mak; T Honjo

  DEVELOPMENT, 1996年01月

  
• ORGANIZATION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; T HONJO

  CYTOGENETICS AND CELL GENETICS, 1994年

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1994年

  
• T-CELL-DERIVED COSTIMULATORY SIGNAL THROUGH THE CD40 MOLECULE RESCUES B-CELLS FROM SURFACE IMMUNOGLOBULIN-MEDIATED CELL-DEATH

  T TSUBATA; J WU; T HONJO

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1993年01月

  
• MOLECULAR-CLONING OF A PROTEIN-BINDING TO THE PROMOTER OF IG C-GAMMA-1 GERM LINE IN THE MOUSE

  E SEVERINSON; M LUNDGREN; TR MIZUTA; J STAVNEZER; T HONJO; A SHIMIZU

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1993年01月

  
• STRUCTURAL-ANALYSIS OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS USING THE YEAST ARTIFICIAL CHROMOSOME (YAC) SYSTEM

  T HONJO; F MATSUDA; EK SHIN; H NAGAOKA; Y FUKITA; S TAKAISHI; T IMAI; K YOKOYAMA; E SOEDA

  CYTOGENETICS AND CELL GENETICS, 1991年

  
• CONTROL OF IL-2 RECEPTOR-ALPHA EXPRESSION BY IL-1, TUMOR-NECROSIS-FACTOR, AND IL-2 - COMPLEX REGULATION VIA ELEMENTS IN THE 5' FLANKING REGION

  G PLAETINCK; MC COMBE; P CORTHESY; P SPERISEN; H KANAMORI; T HONJO; M NABHOLZ

  JOURNAL OF IMMUNOLOGY, 1990年11月

  
• TRANSCRIPTIONAL REGULATION ALONE DOES NOT EXPLAIN THE CONSTITUTIVE EXPRESSION OF THE INTERLEUKIN-2 RECEPTOR (TAC/L-CHAIN) IN HTLV-1 INFECTED-CELLS

  H KANAMORI; N SUZUKI; N ISHIDA; T HONJO

  IMMUNOLOGY LETTERS, 1989年03月

  
• A NEW VECTOR AND RNASE H METHOD FOR THE SUBTRACTIVE HYBRIDIZATION

  K KUZE; A SHIMIZU; T HONJO

  NUCLEIC ACIDS RESEARCH, 1989年01月

  
• ORGANIZATION OF HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN GENES

  F MATSUDA; KH LEE; S NAKAI; T SATO; SQ ZONG; T HONJO

  JAPANESE JOURNAL OF HUMAN GENETICS, 1988年06月

  
• インターロイキンー4(ILー4)/(BSF-1)

  野間 隆文; 本庶 佑

  日本臨牀, 1988年05月

  
• MOUSE IMMUNOGLOBULIN ALLOTYPES - MULTIPLE DIFFERENCES BETWEEN THE NUCLEIC-ACID SEQUENCES OF THE IGEA AND IGEB ALLELES

  Y SHINKAI; H NAKAUCHI; T HONJO; K OKUMURA

  IMMUNOGENETICS, 1988年04月

  
• Structure and Function of Interleukin 4 and 5

  Takafumi Noma; Tasuku Honjo

  Immunological Reviews, 1988年02月

  
• IL-4

  野間 隆文; 本庶 佑

  代謝, 1988年

  
• THE HUMAN IL-2 RECEPTOR GENE CONTAINS A POSITIVE REGULATORY ELEMENT THAT FUNCTIONS IN CULTURED-CELLS AND CELL-FREE-EXTRACTS

  N SUZUKI; N MATSUNAMI; H KANAMORI; N ISHIDA; A SHIMIZU; Y YAOITA; T NIKAIDO; T HONJO

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1987年04月

  
• STRUCTURE AND ORGANIZATION OF HUMAN-IMMUNOGLOBULIN VARIABLE REGION OF THE HEAVY-CHAIN

  T KINASHI; F MATSUDA; KH LEE; M KODAIRA; T NOMA; T HONJO

  JAPANESE JOURNAL OF HUMAN GENETICS, 1986年06月

  
• ORGANIZATION AND EXPRESSION OF LYMPHOCYTE RECEPTOR GENES

  T HONJO; M NISHI; T NIKAIDO; H SABE; J YODOI; N MATSUNAMI; N SUZUKI; S KONDO; A SHIMIZU; Y YAOITA

  DEVELOPMENT GROWTH & DIFFERENTIATION, 1985年

  
• The molecular mechanisms of the immunoglobulin class switch

  Tasuku Honjo

  Immunology Today, 1982年

  
• Organization and reorganization of immunoglobulin heavy-chain genes

  T. Honjo; T. Kataoka; Y. Yaoita; A. Shimizu; N. Takahashi; Y. Yamawaki-Kataoka; T. Nikaido; S. Nakai; M. Obata; T. Kawakami; Y. Nishida

  Cold Spring Harbor Symposia on Quantitative Biology, 1981年

  
• HOMOLOGY OF IMMUNOGLOBULIN GENE BY HETERODUPLEX ANALYSIS

  S NAKAI; H YAMAGISHI; T HONJO

  JAPANESE JOURNAL OF GENETICS, 1980年

  
• The AID Dilemma. Infection, or Cancer?

  Tasuku Honjo; Maki Kobayashi; Nasim Begum; Ai Kotani; Somayeh Sabouri; Hitoshi Nagaoka

  Advances in Cancer Research

  
• Preventing AID, a physiological mutator, from deleterious activation: Regulation of the genomic instability that is associated with antibody diversity

  Hitoshi Nagaoka; Thinh Huy Tran; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo

  International Immunology

  
• Molecular mechanism for generation of antibody memory

  Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A. Begum; Hitoshi Nagaoka; Il Mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo

  Philosophical Transactions of the Royal Society B: Biological Sciences

  
• Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory

  Masamichi Muramatsu; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Nasim A. Begum; Nasim A. Begum; Tasuku Honjo

  Advances in Immunology

  
• AID to overcome the limitations of genomic information by introducing somatic DNA alterations

  Tasuku Honjo; Tasuku Honjo; Tasuku Honjo; Tasuku Honjo; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Reiko Shinkura

  Proceedings of the Japan Academy Series B: Physical and Biological Sciences

  
• Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation

  Ilmi Okazaki; Kiyotsugu Yoshikawa; Kiyotsugu Yoshikawa; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Annals of the New York Academy of Sciences

  
• Uracil DNA glycosylase activity is dispensable for immunloglobulin class switch

  NA Begum; K Kinoshita; N Kakazu; M Muramatsu; H Nagaoka; R Shinkura; D Biniszkiewicz; LA Boyer; R Jaenisch; T Honjo

  SCIENCE, 2004年08月

  
• Constitutive expression of AID leads to tumorigenesis

  Okazaki, I; H Hiai; N Kakazu; S Yamada; M Muramatsu; K Kinoshita; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 2003年05月

  
• AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

  Kiyotsugu Yoshikawa; Il-mi Okazaki; Tomonori Eto; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo

  Science, 2002年06月14日

  
• The AID enzyme induces class switch recombination in fibroblasts

  Il-Mi Okazaki; Kazuo Kinoshita; Masamichi Muramatsu; Klyotsugu Yoshikawa; Tasuku Honjo

  Nature, 2002年03月21日

  
• Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

  H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo

  SCIENCE, 2001年01月

  
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)

  P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Lagelouse; A Gennery; Tezcan, I; F Ersoy; H Kayserili; AG Ugazio; N Brousse; M Muramatsu; LD Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy

  CELL, 2000年09月

  
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

  M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo

  CELL, 2000年09月

  
• Molecular mechanism of immunoglobulin class switch recombination

  K Kinoshita; CG Lee; J Tashiro; M Muramatsu; XC Chen; K Yoshikawa; T Honjo

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1999年

  
• Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

  H Nishimura; M Nose; H Hiai; N Minato; T Honjo

  IMMUNITY, 1999年08月

  
• Notch signalling controls pancreatic cell differentiation

  A Apelqvist; H Li; L Sommer; P Beatus; DJ Anderson; T Honjo; MH de Angelis; U Lendahl; H Edlund

  NATURE, 1999年08月

  
• Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

  R Shinkura; K Kitada; F Matsuda; K Tashiro; K Ikuta; M Suzuki; K Kogishi; T Serikawa; T Honjo

  NATURE GENETICS, 1999年05月

  
• Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

  K Kinoshita; J Tashiro; S Tomita; CG Lee; T Honjo

  IMMUNITY, 1998年12月

  
• Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant

  C Winkler; W Modi; MW Smith; GW Nelson; XY Wu; M Carrington; M Dean; T Honjo; K Tashiro; D Yabe; S Buchbinder; E Vittinghoff; JJ Goedert; TR O'Brien; LP Jacobson; R Detels; S Donfield; A Willoughby; E Gomperts; D Vlahov; J Phair; SJ O'Brien

  SCIENCE, 1998年01月

  
• Frequent but biased class switch recombination in the S mu flanking regions

  CG Lee; S Kondo; T Honjo

  CURRENT BIOLOGY, 1998年02月

  
• The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

  F Matsuda; K Ishii; P Bourvagnet; K Kuma; H Hayashida; T Miyata; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 1998年12月

  
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

  H Kato; Y Taniguchi; H Kurooka; S Minoguchi; T Sakai; S NomuraOkazaki; K Tamura; T Honjo

  DEVELOPMENT, 1997年10月

  
• Conservation of the Notch signalling pathway in mammalian neurogenesis

  J delaPompa; A Wakeham; KM Correia; E Samper; S Brown; RJ Aguilera; T Nakano; T Honjo; TW Mak; J Rossant; RA Conlon

  DEVELOPMENT, 1997年03月

  
• Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice

  M Murakami; K Nakajima; K Yamazaki; T Muraguchi; T Serikawa; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, 1997年02月

  
• In vitro development of primitive and definitive erythrocytes from different precursors

  T Nakano; H Kodama; T Honjo

  SCIENCE, 1996年05月

  
• The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor.

  Genes to Cells, 1996年

  
• Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

  K Tamura; Y Taniguchi; S Minoguchi; T Sakai; T Tun; T Furukawa; T Honjo

  CURRENT BIOLOGY, 1995年12月

  
• DISRUPTION OF THE MOUSE RBP-J-KAPPA GENE RESULTS IN EARLY EMBRYONIC DEATH

  C OKA; T NAKANO; A WAKEHAM; JL DELAPOMPA; C MORI; T SAKAI; S OKAZAKI; M KAWAICHI; K SHIOTA; TW MAK; T HONJO

  DEVELOPMENT, 1995年10月

  
• EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 EXERTS ITS TRANSACTIVATING FUNCTION THROUGH INTERACTION WITH RECOMBINATION SIGNAL BINDING-PROTEIN RBP-J-KAPPA, THE HOMOLOG OF DROSOPHILA SUPPRESSOR OF HAIRLESS

  U ZIMBERSTROBL; LJ STROBL; C MEITINGER; R HINRICHS; T SAKAI; T FURUKAWA; T HONJO; GW BORNKAMM

  EMBO JOURNAL, 1994年10月

  
• GENERATION OF LYMPHOHEMATOPOIETIC CELLS FROM EMBRYONIC STEM-CELLS IN CULTURE

  T NAKANO; H KODAMA; T HONJO

  SCIENCE, 1994年08月

  
• ORAL-ADMINISTRATION OF LIPOPOLYSACCHARIDES ACTIVATES B-1 CELLS IN THE PERITONEAL-CAVITY AND LAMINA PROPRIA OF THE GUT AND INDUCES AUTOIMMUNE SYMPTOMS IN AN AUTOANTIBODY TRANSGENIC MOUSE

  M MURAKAMI; T TSUBATA; R SHINKURA; S NISITANI; M OKAMOTO; H YOSHIOKA; T USUI; S MIYAWAKI; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1994年07月

  
• ANTIGEN-RECEPTOR CROSS-LINKING INDUCES PERITONEAL B-CELL APOPTOSIS IN NORMAL BUT NOT AUTOIMMUNITY-PRONE MICE

  T TSUBATA; M MURAKAMI; T HONJO

  CURRENT BIOLOGY, 1994年01月

  
• B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY A T-CELL SIGNAL THROUGH CD40

  T TSUBATA; J WU; T HONJO

  NATURE, 1993年08月

  
• THE BCL-2 GENE-PRODUCT INHIBITS CLONAL DELETION OF SELF-REACTIVE B-LYMPHOCYTES IN THE PERIPHERY BUT NOT IN THE BONE-MARROW

  S NISITANI; T TSUBATA; M MURAKAMI; M OKAMOTO; T HONJO

  JOURNAL OF EXPERIMENTAL MEDICINE, 1993年10月

  
• STRUCTURE AND PHYSICAL MAP OF 64 VARIABLE SEGMENTS IN THE 3(I)0.8-MEGABASE REGION OF THE HUMAN-IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

  F MATSUDA; EK SHIN; H NAGAOKA; R MATSUMURA; M HAINO; Y FUKITA; S TAKAISHI; T IMAI; JH RILEY; R ANAND; E SOEDA; T HONJO

  NATURE GENETICS, 1993年01月

  
• SIGNAL SEQUENCE TRAP - A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE-I MEMBRANE-PROTEINS

  K TASHIRO; H TADA; R HEILKER; M SHIROZU; T NAKANO; T HONJO

  SCIENCE, 1993年07月

  
• THE DROSOPHILA HOMOLOG OF THE IMMUNOGLOBULIN RECOMBINATION SIGNAL BINDING-PROTEIN REGULATES PERIPHERAL NERVOUS-SYSTEM DEVELOPMENT

  T FURUKAWA; S MARUYAMA; M KAWAICHI; T HONJO

  CELL, 1992年06月

  
• ANTIGEN-INDUCED APOPTOTIC DEATH OF LY-1 B-CELLS RESPONSIBLE FOR AUTOIMMUNE-DISEASE IN TRANSGENIC MICE

  M MURAKAMI; T TSUBATA; M OKAMOTO; A SHIMIZU; S KUMAGAI; H IMURA; T HONJO

  NATURE, 1992年05月

  
• CIRCULAR DNA IS EXCISED BY IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION

  T IWASATO; A SHIMIZU; T HONJO; H YAMAGISHI

  CELL, 1990年07月

  
• A PROTEIN-BINDING TO THE J-KAPPA RECOMBINATION SEQUENCE OF IMMUNOGLOBULIN GENES CONTAINS A SEQUENCE RELATED TO THE INTEGRASE MOTIF

  N MATSUNAMI; Y HAMAGUCHI; Y YAMAMOTO; K KUZE; K KANGAWA; H MATSUO; M KAWAICHI; T HONJO

  NATURE, 1989年12月

  
• CLONING OF CDNA-ENCODING THE MURINE IGG1 INDUCTION FACTOR BY A NOVEL STRATEGY USING SP6 PROMOTER

  Y NOMA; P SIDERAS; T NAITO; S BERGSTEDTLINDQUIST; C AZUMA; E SEVERINSON; T TANABE; T KINASHI; F MATSUDA; Y YAOITA; T HONJO

  NATURE, 1986年02月

  
• CLONING OF COMPLEMENTARY-DNA ENCODING T-CELL REPLACING FACTOR AND IDENTITY WITH B-CELL GROWTH FACTOR-II

  T KINASHI; N HARADA; E SEVERINSON; T TANABE; P SIDERAS; M KONISHI; C AZUMA; A TOMINAGA; S BERGSTEDTLINDQVIST; M TAKAHASHI; F MATSUDA; Y YAOITA; K TAKATSU; T HONJO

  NATURE, 1986年11月

  
• INTERLEUKIN 1A MESSENGER-RNA IN VIRUS-TRANSFORMED T-CELLS AND B-CELLS

  T NOMA; T NAKAMURA; M MAEDA; M OKADA; Y TANIGUCHI; Y TAGAYA; Y YAOITA; J YODOI; T HONJO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986年08月

  
• MOLECULAR-CLONING OF CDNA-ENCODING HUMAN INTERLEUKIN-2 RECEPTOR

  T NIKAIDO; A SHIMIZU; N ISHIDA; H SABE; K TESHIGAWARA; M MAEDA; T UCHIYAMA; J YODOI; T HONJO

  NATURE, 1984年

  
• Immunogloblin class switching

  Cell 36,801-803, 1984年

  
• Immunoglobulin genes.

  Ann. Rev. Immunol., 1983年

  
• ORGANIZATION OF THE CONSTANT-REGION GENE FAMILY OF THE MOUSE IMMUNOGLOBULIN HEAVY-CHAIN

  A SHIMIZU; N TAKAHASHI; Y YAOITA; T HONJO

  CELL, 1982年

  
• SWITCH REGION OF IMMUNOGLOBULIN C-MU-GENE IS COMPOSED OF SIMPLE TANDEM REPETITIVE SEQUENCES

  T NIKAIDO; S NAKAI; T HONJO

  NATURE, 1981年

  
• ORDERING OF MOUSE IMMUNOGLOBULIN HEAVY-CHAIN GENES BY MOLECULAR-CLONING

  A SHIMIZU; N TAKAHASHI; Y YAMAWAKIKATAOKA; Y NISHIDA; T KATAOKA; T HONJO

  NATURE, 1981年

  
• Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination

  Cell 18,559-568, 1979年

  
• Organization of immnoglobulin heavy chain genes and allelic deletion model

  Proceeding of National Academy of Science 75,2140-2144, 1978年

  

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