Basic Information

Professional Memberships

• The Japanese Society of Immunology
• The Japanese Society of Hematopoietic Cell Transplantation
• The Japanese Society of Hematology
• The Japanese Society of Internal Medicine

Academic Degree

• 博士（医学）(京都大学)

Research History

• From 01 Aug. 2015

  Kyoto University Hospital, Assistant professor
• From 01 Feb. 2015

  Otsu Red Cross Hospital, Chief doctor
• From 01 Nov. 2010

  Kyoto University Hospital, Assistant Professor
• From 01 Apr. 2008

  Kyoto University Hospital, Researcher
• From 01 Nov. 2003

  Kyoto University Hospital, Assistant Professor
• From 01 Apr. 2003

  Faculty of Medicine, Kyoto University, Reseacher
• From 01 Jun. 1997

  Kurashiki Central Hospital, Resident of Internal Medicine
• From 16 May 1996

  Kyoto University Hospital, Resident of Internal Medicine

Profile

• Profile

  I am a doctor in the Department of Hematology and Oncology, Kyoto University Hospital. I am combating hematological malignancies, such as leukemia and malignant lymphoma, every day. My dream is to develop a novel therapy for hematological malignancies by elucidating the interactions between tumors and the immune system. Now, I am specifically working on clinical trials of dendritic cell-based immunotherapy for patients with leukemia and melanoma.

ID,URL

• J-Global ID

  201401090337837252

researchmap URL

• https://researchmap.jp/7000009031

Research

Research Topics, Overview of the research

• Research Topics

  Immunotherapy for hematologic malignancies

• Overview of the research

  Immunotherapy for hematological malignancies has made great advancement in recent years, including chimeric antigen receptor T-cell therapy and bispecific antibodies. To take advantage of these new therapeutic modalities and further improve therapeutic outcomes, we are conducting research to improve chimeric antigen receptor T-cell therapy and elucidate the mechanisms of therapeutic resistance to immunotherapy.

Research Interests

• Immunotherapy
• Dendritic cells

Research Areas

• Life sciences, Hematology and oncology

Papers

• CAR-T細胞療法後に肺動脈内のT細胞塊を認めたtriple-hit DLBCLの1例

  中村 直和; 錦織 桃子; 水本 智咲; 阪本 貴士; 諫田 淳也; 白川 康太郎; 北脇 年雄; 近藤 忠一; 山下 浩平; 高折 晃史

  臨床血液, Aug. 2022

  
• 嚥下障害を伴う治療関連急性骨髄性白血病に対してベネトクラクスを導入した1例

  中村 名欧; 和田 典也; 阪本 貴士; 諫田 淳也; 山際 岳朗; 米澤 淳; 寺田 智祐; 水本 智咲; 北脇 年雄; 近藤 忠一; 山下 浩平; 高折 晃史

  臨床血液, Feb. 2022

  
• [Concentration of gilteritinib in the cerebrospinal fluid of a patient with relapsed FLT3-ITD positive acute myeloid leukemia with optic nerve involvement].

  Yuta Suzuki; Toshio Kitawaki; Yasuyuki Arai; Shunsaku Nakagawa; Kazuhisa Chonabayashi; Yasuhito Nannya; Kouhei Yamashita; Seishi Ogawa; Akifumi Takaori-Kondo

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2024

  
• Methotrexate-induced subacute myelopathy: a serious but treatable complication.

  Takashi Miyoshi; Tadakazu Kondo; Momoko Nishikori; Toshio Kitawaki; Katsuya Kobayashi; Masakazu Fujimoto; Noriyoshi Yoshinaga; Satoshi Oka; Kohsuke Asagoe; Shinsaku Imashuku; Akifumi Takaori-Kondo

  Journal of clinical and experimental hematopathology : JCEH, 2023

  
• Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

  Naokazu Nakamura; Tomoyasu Jo; Yasuyuki Arai; Toshio Kitawaki; Momoko Nishikori; Chisaki Mizumoto; Junya Kanda; Kouhei Yamashita; Miki Nagao; Akifumi Takaori-Kondo

  Clinical and Experimental Medicine, 21 May 2024

  
• Clinical impact of CRS on prolonged hematotoxicity after CAR-T cell therapy: KyoTox a-score, a novel prediction model.

  Naokazu Nakamura; Tomoyasu Jo; Yasuyuki Arai; Toshio Kitawaki; Momoko Nishikori; Chisaki Mizumoto; Junya Kanda; Kouhei Yamashita; Miki Nagao; Akifumi Takaori-Kondo

  Transplantation and cellular therapy, 26 Jan. 2024

  
• KyoTox-e score; prediction of post-CAR-T prolonged thrombocytopenia using peripheral blood data before apheresis

  Tomoyasu Jo; Yasuyuki Arai; Toshio Kitawaki; Naokazu Nakamura; Momoko Nishikori; Chisaki Mizumoto; Junya Kanda; Kouhei Yamashita; Miki Nagao; Akifumi Takaori-Kondo

  Bone Marrow Transplantation, 19 Dec. 2023

  
• Risk analysis of fluctuating hypercalcemia after leukapheresis in cellular therapy

  Tomoyasu Jo; Yasuyuki Arai; Toshio Kitawaki; Momoko Nishikori; Chisaki Mizumoto; Junya Kanda; Kouhei Yamashita; Miki Nagao; Akifumi Takaori-Kondo

  Scientific Reports, 11 Sep. 2023

  Access this paper :

  
• Impact of Antimicrobial Drug-Drug Interactions on Acute Kidney Injury after Allogeneic Hematopoietic Cell Transplantation

  Fumiya Wada; Yasuyuki Arai; Tomoyasu Jo; Chisaki Mizumoto; Junya Kanda; Toshio Kitawaki; Momoko Nishikori; Kouhei Yamashita; Akifumi Takaori-Kondo

  Transplantation and Cellular Therapy, Jul. 2023

  
• Pretreatment blast-to-lymphocyte ratio as a prognostic marker for CD19/CD3-bispecific T cell-engaging antibodies (blinatumomab) treatment against relapsed or refractory B-precursor acute lymphoblastic leukemia.

  Yutaka Shimazu; Toshio Kitawaki; Tadakazu Kondo; Akifumi Takaori-Kondo

  Cancer immunology, immunotherapy : CII, 07 Aug. 2023

  
• T-cell counts in peripheral blood at leukapheresis predict responses to subsequent CAR-T cell therapy

  Fumiya Wada; Tomoyasu Jo; Yasuyuki Arai; Toshio Kitawaki; Chisaki Mizumoto; Junya Kanda; Momoko Nishikori; Kouhei Yamashita; Miki Nagao; Akifumi Takaori-Kondo

  Scientific Reports, 04 Nov. 2022

  Access this paper :

  
• Significance of Omitting Day 11 Mini-Dose Methotrexate for GVHD Prophylaxis After Unrelated Bone Marrow Transplantation

  Naokazu Nakamura; Fumiya Wada; Tadakazu Kondo; Kazunari Aoki; Yasuyuki Arai; Chisaki Mizumoto; Junya Kanda; Toshio Kitawaki; Kouhei Yamashita; Akifumi Takaori-Kondo

  Transplantation and Cellular Therapy, Nov. 2022

  
• Decreased serum phosphate levels are a useful biomarker to predict occurrence and severity of cytokine release syndrome in chimeric antigen receptor T ‐cell therapy

  Naokazu Nakamura; Yasuyuki Arai; Toshio Kitawaki; Tomoyasu Jo; Chisaki Mizumoto; Junya Kanda; Momoko Nishikori; Kouhei Yamashita; Akifumi Takaori‐Kondo

  British Journal of Haematology, 11 Oct. 2022

  
• Effects of combined test-dose and therapeutic drug monitoring strategy in exposure-directed busulfan

  Tomoki Iemura; Tadakazu Kondo; Atsushi Ueda; Takeshi Maeda; Toshio Kitawaki; Yasuyuki Arai; Junya Kanda; Takashi Ikeda; Kazunori Imada; Takayuki Ishikawa; Naoyuki Anzai; Mitsuru Itoh; Tomoharu Takeoka; Takashi Akasaka; Kazuhiro Yago; Akihito Yonezawa; Nobuyoshi Arima; Toshiyuki Kitano; Masaharu Nohgawa; Mitsumasa Watanabe; Toshinori Moriguchi; Kouhei Yamashita; Yasunori Ueda; Kana Matsumoto; Akifumi Takaori-Kondo

  05 Jul. 2022

  
• Addition and drug monitoring of mycophenolate mofetil for GVHD prophylaxis in unrelated bone marrow transplantation

  Fumiya Wada; Tadakazu Kondo; Ryusuke Yamamoto; Takero Yamagiwa; Yasuyuki Arai; Chisato Mizumoto; Junya Kanda; Toshio Kitawaki; Kouhei Yamashita; Akifumi Takaori-Kondo

  Bone Marrow Transplantation, Jul. 2022

  
• Coexistence of HLA and KIR ligand mismatches as a risk factor for viral infection early after cord blood transplantation

  Tomoki Iemura; Yasuyuki Arai; Toshio Kitawaki; Junya Kanda; Tadakazu Kondo; Yasunori Ueda; Takuto Mori; Kazunori Imada; Akihito Yonezawa; Kazuhiro Yago; Naoyuki Anzai; Shinichi Kotani; Masaharu Nohgawa; Toshiyuki Kitano; Mitsuru Itoh; Nobuyoshi Arima; Toshinori Moriguchi; Mitsumasa Watanabe; Masaaki Tsuji; Kouhei Yamashita; Akifumi Takaori-Kondo

  Bone Marrow Transplantation, May 2022

  
• Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

  Yosuke Nagahata; Kyoko Masuda; Yuji Nishimura; Tomokatsu Ikawa; Shinpei Kawaoka; Toshio Kitawaki; Yasuhito Nannya; Seishi Ogawa; Hiroshi Suga; Yutaka Satou; Akifumi Takaori-Kondo; Hiroshi Kawamoto

  Blood, 15 Dec. 2022

  
• Relative hypercoagulation induced by suppressed fibrinolysis after tisagenlecleucel infusion in malignant lymphoma.

  Makiko Yamasaki-Morita; Yasuyuki Arai; Takashi Ishihara; Tomoko Onishi; Hanako Shimo; Kayoko Nakanishi; Yukiko Nishiyama; Tomoyasu Jo; Hidefumi Hiramatsu; Takaya Mitsuyoshi; Chisaki Mizumoto; Junya Kanda; Momoko Nishikori; Toshio Kitawaki; Keiji Nogami; Akifumi Takaori-Kondo; Miki Nagao; Souichi Adachi

  Blood advances, 26 Jul. 2022

  Access this paper :

  
• A Clinically Applicable Prediction Model to Improve T Cell Collection in Chimeric Antigen Receptor T Cell Therapy.

  Tomoyasu Jo; Satoshi Yoshihara; Asuka Hada; Yasuyuki Arai; Toshio Kitawaki; Junko Ikemoto; Hitomi Onomoto; Hiroki Sugiyama; Kyoko Yoshihara; Natsuno Obi; Keiko Matsui; Norimi Niwa; Yoko Nakagawa; Junya Kanda; Tadakazu Kondo; Satoshi Saida; Itaru Kato; Hidefumi Hiramatsu; Souichi Adachi; Junko Takita; Akifumi Takaori-Kondo; Miki Nagao

  Transplantation and cellular therapy, Jul. 2022

  Access this paper :

  
• Development of dendritic cell-based immunotherapy for elderly patients with acute myeloid leukemia

  KITAWAKI Toshio

  Cytometry Research, 25 Mar. 2012

  
• The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B-cell lymphoma and enhances T-cell recruitment.

  Hepei Yuan; Momoko Nishikori; Yasuyuki Otsuka; Hiroshi Arima; Toshio Kitawaki; Akifumi Takaori-Kondo

  Cancer science, Nov. 2021

  Access this paper :

  
• Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs(和訳中)

  中村 桃子; 蝶名林 和久; 森本 有紀; 越智 陽太郎; 南谷 泰仁; 北脇 年雄; 菱澤 方勝; 小川 誠司; 高折 晃史; 吉田 善紀

  日本血液学会学術集会, Sep. 2021

  
• Development of a quantitative prediction model for peripheral blood stem cell collection yield in the plerixafor era

  Akira Ishii; Tomoyasu Jo; Yasuyuki Arai; Shinichiro Oshima; Junya Kanda; Toshio Kitawaki; Keiko Matsui; Norimi Niwa; Yoko Nakagawa; Akifumi Takaori-Kondo; Miki Nagao

  Cytotherapy, Jan. 2022

  Access this paper :

  
• A sporadic case of CTLA4 haploinsufficiency manifesting as Epstein-Barr virus-positive diffuse large B-cell lymphoma.

  Hepei Yuan; Momoko Nishikori; Chiyoko Ueda; Masakazu Fujimoto; Takahiro Yasumi; Yasuyuki Otsuka; Toshio Kitawaki; Masahiro Hirata; Hironori Haga; Hirokazu Kanegane; Akifumi Takaori-Kondo

  Journal of clinical and experimental hematopathology : JCEH, 26 Oct. 2021

  
• Programmed cell death 1‐expressing CD56‐negative natural killer (NK) cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment

  Ken‐ichi Ishiyama; Toshio Kitawaki; Yasuyuki Otsuka; Akifumi Takaori‐Kondo; Norimitsu Kadowaki

  Cancer Science, Feb. 2021

  Access this paper :

  
• Next‐generation sequencing in two cases of de novo acute basophilic leukaemia

  Takuya Shimizu; Tadakazu Kondo; Yasuhito Nannya; Mizuki Watanabe; Toshio Kitawaki; Takero Shindo; Masakatsu Hishizawa; Kouhei Yamashita; Seishi Ogawa; Akifumi Takaori‐Kondo

  Journal of Cellular and Molecular Medicine, Jul. 2021

  Access this paper :

  
• CD19 CAR-T細胞療法における白血球アフェレーシスの経験 国内最多2施設による共同研究

  城 友泰; 吉原 哲; 新井 康之; 池本 純子; 小野本 仁美; 杉山 寛貴; 吉原 享子; 松井 恵子; 丹羽 紀実; 中川 陽子; 北脇 年雄; 諫田 淳也; 高折 晃史; 長尾 美紀

  臨床血液, Mar. 2021

  
• Oncolytic Virus Therapy with HSV-1 for Hematological Malignancies.

  Ryo Ishino; Yumi Kawase; Toshio Kitawaki; Naoshi Sugimoto; Maki Oku; Shumpei Uchida; Osamu Imataki; Akihito Matsuoka; Teruhisa Taoka; Kimihiro Kawakami; Toin H van Kuppevelt; Tomoki Todo; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  Molecular therapy : the journal of the American Society of Gene Therapy, 03 Feb. 2021

  
• [Clinical experience of leukapheresis for CD19 CAR-T cell therapy].

  Tomoyasu Jo; Satoru Yoshihara; Yasuyuki Arai; Junko Ikemoto; Hitomi Onomoto; Hiroki Sugiyama; Kyoko Yoshihara; Keiko Matsui; Norimi Niwa; Yoko Nakagawa; Toshio Kitawaki; Junya Kanda; Akifumi Takaori-Kondo; Miki Nagao

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2021

  
• Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

  Takuya Maeda; Seiji Nagano; Soki Kashima; Koji Terada; Yasutoshi Agata; Hiroshi Ichise; Manami Ohtaka; Mahito Nakanishi; Fumihiro Fujiki; Haruo Sugiyama; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Molecular therapy. Methods & clinical development, 11 Dec. 2020

  
• Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation.

  Tomoki Iemura; Yasuyuki Arai; Junya Kanda; Toshio Kitawaki; Masakatsu Hishizawa; Tadakazu Kondo; Kouhei Yamashita; Akifumi Takaori-Kondo

  Scientific reports, 03 Dec. 2020

  
• High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

  Seiji Nagano; Takuya Maeda; Hiroshi Ichise; Soki Kashima; Manami Ohtaka; Mahito Nakanishi; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Molecular therapy. Methods & clinical development, 13 Mar. 2020, Peer-reviewed

  
• EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas.

  Yasuyuki Otsuka; Momoko Nishikori; Hiroshi Arima; Kiyotaka Izumi; Toshio Kitawaki; Masakatsu Hishizawa; Akifumi Takaori-Kondo

  Molecular immunology, Mar. 2020, Peer-reviewed

  
• Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.

  Atsushi Tanaka; Hiroyoshi Nishikawa; Shinsuke Noguchi; Daisuke Sugiyama; Hiromasa Morikawa; Yoshiko Takeuchi; Danbee Ha; Naoya Shigeta; Toshio Kitawaki; Yuka Maeda; Takuro Saito; Yoshinori Shinohara; Yoshihiro Kameoka; Keiko Iwaisako; Fumihiko Monma; Kohshi Ohishi; Julia Karbach; Elke Jäger; Kenichi Sawada; Naoyuki Katayama; Naoto Takahashi; Shimon Sakaguchi

  The Journal of experimental medicine, 03 Feb. 2020, Peer-reviewed

  
• 多発溶骨性病変と高カルシウム血症を伴った若年diffuse large B-cell lymphomaの1例

  増尾 優輝; 阪本 貴士; 北脇 年雄; 櫻田 紘基; 菱澤 方勝; 近藤 忠一; 山下 浩平; 高折 晃史

  臨床血液, Feb. 2020

  
• Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis.

  Kazuhisa Chonabayashi; Yoshinori Yoshida; Toshio Kitawaki; Yasuhito Nannya; Momoko Nakamura; Shinichiro Oshima; Masakatsu Hishizawa; Kouhei Yamashita; Seishi Ogawa; Akifumi Takaori-Kondo

  Annals of hematology, Dec. 2019, Peer-reviewed

  
• Anti-inflammatory modulation of human myeloid-derived dendritic cell subsets by lenalidomide.

  Kazuyo Yamamoto; Toshio Kitawaki; Naoshi Sugimoto; Haruyuki Fujita; Yumi Kawase; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  Immunology letters, Jul. 2019, Peer-reviewed

  
• Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab.

  Ichiro Yamauchi; Akihiro Yasoda; Shigemi Matsumoto; Yuichi Sakamori; Young Hak Kim; Motoo Nomura; Atsushi Otsuka; Toshinari Yamasaki; Ryoichi Saito; Morimasa Kitamura; Toshio Kitawaki; Masakatsu Hishizawa; Nobuko Kawaguchi-Sakita; Toshihito Fujii; Daisuke Taura; Masakatsu Sone; Nobuya Inagaki

  PloS one, 2019, Peer-reviewed

  Access this paper :

  
• Cytomegalovirus pulls strings behind NK cells

  Norimitsu Kadowaki; Kenichi Ishiyama; Toshio Kitawaki

  Oncotarget, 01 Nov. 2017, Peer-reviewed

  
• Principal component analysis uncovers cytomegalovirus-associated NK cell activation in Ph+ leukemia patients treated with dasatinib

  K Ishiyama; T. Kitawaki; N. Sugimoto; T. Sozu; N. Anzai; M. Okada; M. Nohgawa; K. Hatanaka; N. Arima; T. Ishikawa; S. Tabata; T. Onaka; S. Oka; Y. Nakabo; R. Amakawa; M. Matsui; T. Moriguchi; A. Takaori-Kondo; N. Kadowaki

  LEUKEMIA, Jan. 2017, Peer-reviewed

  
• Regeneration of CD8αβ T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity.

  Takuya Maeda; Seiji Nagano; Hiroshi Ichise; Keisuke Kataoka; Daisuke Yamada; Seishi Ogawa; Haruhiko Koseki; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Cancer research, 01 Dec. 2016, Peer-reviewed

  
• Expression of Tim-1 in primary CNS lymphoma

  Wataru Kishimoto; Momoko Nishikori; Hiroshi Arima; Hiroaki Miyoshi; Yuya Sasaki; Toshio Kitawaki; Kotaro Shirakawa; Takeharu Kato; Yoshitaka Imaizumi; Takayuki Ishikawa; Hitoshi Ohno; Hironori Haga; Koichi Ohshima; Akifumi Takaori-Kondo

  Cancer Medicine, 01 Nov. 2016, Peer-reviewed

  Access this paper :

  
• Increased number of peripheral CD8⁺ T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine

  Momoko Nishikori; Toshiyuki Kitano; Masayuki Kobayashi; Masakatsu Hishizawa; Toshio Kitawaki; Tadakazu Kondo; Kouhei Yamashita; Hiroshi Kawabata; Norimitsu Kadowaki; Yusuke Takei; Hironori Haga; Akifumi Takaori-Kondo

  International Journal of Hematology, 23 Jul. 2015, Peer-reviewed

  Access this paper :

  
• DC-based immunotherapy for hematological malignancies

  Toshio Kitawaki

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Feb. 2014, Peer-reviewed

  
• Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.

  Takayuki Sato; Toshio Kitawaki; Haruyuki Fujita; Makoto Iwata; Tomonori Iyoda; Kayo Inaba; Toshiaki Ohteki; Suguru Hasegawa; Kenji Kawada; Yoshiharu Sakai; Hiroki Ikeuchi; Hiroshi Nakase; Akira Niwa; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  Journal of immunology (Baltimore, Md. : 1950), 15 Sep. 2013, Peer-reviewed

  
• Cellular immunotherapy for leukemia

  Norimitsu Kadowaki; Toshio Kitawaki

  Drug Delivery System, Apr. 2013, Peer-reviewed

  
• The tyrosine kinase inhibitor dasatinib suppresses cytokine production by plasmacytoid dendritic cells by targeting endosomal transport of CpG DNA

  Haruyuki Fujita; Toshio Kitawaki; Takayuki Sato; Takahiro Maeda; Shimeru Kamihira; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  EUROPEAN JOURNAL OF IMMUNOLOGY, Jan. 2013, Peer-reviewed

  
• Clinical features and treatment of multicentric castleman's disease : a retrospective study of 21 Japanese patients at a single institute.

  Hiroshi Kawabata; Norimitsu Kadowaki; Momoko Nishikori; Toshio Kitawaki; Tadakazu Kondo; Takayuki Ishikawa; Hajime Yoshifuji; Noriyuki Yamakawa; Yoshitaka Imura; Tsuneyo Mimori; Yumi Matsumura; Yoshiki Miyachi; Takeshi Matsubara; Motoko Yanagita; Hironori Haga; Akifumi Takaori-Kondo

  Journal of clinical and experimental hematopathology : JCEH, 2013, Peer-reviewed

  
• A phase I/IIa clinical trial of immunotherapy for elderly patients with acute myeloid leukaemia using dendritic cells co-pulsed with WT1 peptide and zoledronate

  Toshio Kitawaki; Norimitsu Kadowaki; Keiko Fukunaga; Yasunari Kasai; Taira Maekawa; Katsuyuki Ohmori; Takashige Kondo; Ryuji Maekawa; Masashi Takahara; Mie Nieda; Kiyotaka Kuzushima; Takayuki Ishikawa; Takashi Uchiyama

  BRITISH JOURNAL OF HAEMATOLOGY, Jun. 2011, Peer-reviewed

  
• Cross-priming of CD8(+) T cells in vivo by dendritic cells pulsed with autologous apoptotic leukemic cells in immunotherapy for elderly patients with acute myeloid leukemia

  Toshio Kitawaki; Norimitsu Kadowaki; Keiko Fukunaga; Yasunari Kasai; Taira Maekawa; Katsuyuki Ohmori; Tatsuya Itoh; Akira Shimizu; Kiyotaka Kuzushima; Tadakazu Kondo; Takayuki Ishikawa; Takashi Uchiyama

  EXPERIMENTAL HEMATOLOGY, Apr. 2011, Peer-reviewed

  
• Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis

  Makiko Hirai; Norimitsu Kadowaki; Toshio Kitawaki; Haruyuki Fujita; Akifumi Takaori-Kondo; Ryutaro Fukui; Kensuke Miyake; Takahiro Maeda; Shimeru Kamihira; Yoshiki Miyachi; Takashi Uchiyama

  BLOOD, Jan. 2011, Peer-reviewed

  
• [Therapy for malignancies and inflammatory disorders by modulating human dendritic cell functions].

  N. Kadowaki; T. Kitawaki; M. Hirai

  [Rinshō ketsueki] The Japanese journal of clinical hematology, 2011, Peer-reviewed

  
• Recent Advance in Antigen-Specific Immunotherapy for Acute Myeloid Leukemia

  Norimitsu Kadowaki; Toshio Kitawaki

  CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011, Peer-reviewed

  Access this paper :

  
• A phase I/II study of immunotherapy for elderly patients with acute myeloid leukemia using dendritic cells pulsed with autologous apoptotic leukemic cells.

  Kitawaki, T; Kadowaki, T; Fukunaga, K; Kasai, Y; Maekawa, T; Ohmori, K; Itoh, T; Tada, H; Teramukai, S; Shimizu, A; Fukushima, M; Kuzushima, K; Kondo, T; Ishikawa, T; Uchiyama, T

  Brit J Haematol, 53(6):796-799, 2011, Peer-reviewed

  
• Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4+T-cell differentiation

  Kazue Arimoto-Miyamoto; Norimitsu Kadowaki; Toshio Kitawaki; Satoshi Iwata; Chikao Morimoto; Takashi Uchiyama

  IMMUNOLOGY, May 2010, Peer-reviewed

  
• Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type

  Tomomi Sakai; Momoko Nishikori; Masaharu Tashima; Ryo Yamamoto; Toshio Kitawaki; Akifumi Takaori-Kondo; Takayo Suzuki; Shinobu Tsuzuki; Takashi Uchiyama

  CANCER SCIENCE, Dec. 2009, Peer-reviewed

  
• The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans

  Mutsumi Hashimoto-Okada; Toshio Kitawaki; Norimitsu Kadowaki; Satoshi Iwata; Chikao Morimoto; Toshiyuki Hori; Takashi Uchiyama

  INTERNATIONAL IMMUNOLOGY, Aug. 2009, Peer-reviewed

  Access this paper :

  
• Dendritic cell-based tumor immunotherapy.

  N. Kadowaki; T. Kitawaki

  [Rinshō ketsueki] The Japanese journal of clinical hematology, 2009, Peer-reviewed

  
• Potential of dendritic cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide- and keyhole limpet hemocyanin-pulsed, donor-derived dendritic cell vaccine for acute myeloid leukemia

  Toshio Kitawaki; Norimitsu Kadowaki; Tadakazu Kondo; Takayuki Ishikawa; Tatsuo Ichinohe; Satoshi Teramukai; Masanori Fukushima; Yasunari Kasai; Taira Maekawa; Takashi Uchiyama

  AMERICAN JOURNAL OF HEMATOLOGY, Apr. 2008, Peer-reviewed

  
• PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma

  Ryo Yamamoto; Momoko Nishikori; Toshio Kitawaki; Tomomi Sakai; Masakatsu Hishizawa; Masaharu Tashima; Tadakazu Kondo; Katsuyuki Ohmori; Masayuki Kurata; Takamasa Hayashi; Takashi Uchiyama

  BLOOD, Mar. 2008, Peer-reviewed

  
• IgE-activated mast cells in combination with pro-inflammatory factors induce T(h)2-promoting dendritic cells

  Toshio Kitawaki; Norimitsu Kadowaki; Naoshi Sugimoto; Naotomo Kambe; Toshiyuki Hori; Yoshiki Miyachi; Tatsutoshi Nakahata; Takashi Uchiyama

  INTERNATIONAL IMMUNOLOGY, Dec. 2006, Peer-reviewed

  
• Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity

  K Kawamura; N Kadowaki; R Suzuki; S Udagawa; S Kasaoka; N Utoguchi; T Kitawaki; N Sugimoto; N Okada; K Maruyama; T Uchiyama

  JOURNAL OF IMMUNOTHERAPY, Mar. 2006, Peer-reviewed

  
• Virus-stimulated plasmacytoid dendritic cells induce CD4(+) cytotoxic regulatory T cells

  K Kawamura; N Kadowaki; T Kitawaki; T Uchiyama

  BLOOD, Feb. 2006, Peer-reviewed

  
• Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4(+) T cells

  S Tabata; N Kadowaki; T Kitawaki; T Shimaoka; S Yonehara; O Yoshie; T Uchiyama

  JOURNAL OF LEUKOCYTE BIOLOGY, May 2005, Peer-reviewed

  
• Crucial role of FOXP3 in the development and function of human CD25(+)CD4(+) regulatory T cells

  H Yagi; T Nomura; K Nakamura; S Yamazaki; T Kitawaki; S Hori; M Maeda; M Onodera; T Uchiyama; S Fujii; S Sakaguchi

  INTERNATIONAL IMMUNOLOGY, Nov. 2004, Peer-reviewed

  
• Depletion and impaired interferon-alpha-producing capacity of blood plasmacytoid dendritic cells in human T-cell leukaemia virus type I-infected individuals

  M Hishizawa; K Imada; T Kitawaki; M Ueda; N Kadowaki; T Uchiyama

  BRITISH JOURNAL OF HAEMATOLOGY, Jun. 2004, Peer-reviewed

  
• Crucial role of FOXP3 in the development of human CD25＋4＋ regulatory T cells.

  Haruhiko Yagi; Takashi Nomura; Kyoko Nakamura; Toshio Kitawaki; Masafumi Onodera; Takashi Uchiyama; Shingo Fujii; Shimon Sakaguchi

  Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）, 2004, Peer-reviewed

  
• Coexistent Rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma

  C Ueda; M Nishikori; T Kitawaki; T Uchiyama; H Ohno

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Jan. 2004, Peer-reviewed

  
• Compromised recovery of natural interferon-alpha/beta-producing cells after allogeneic hematopoietic stem cell transplantation complicated by acute graft-versus-host disease and glucocorticoid administration

  T Kitawaki; N Kadowaki; T Ishikawa; T Ichinohe; T Uchiyama

  BONE MARROW TRANSPLANTATION, Jul. 2003, Peer-reviewed

  
• Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells

  A Yonezawa; R Morita; A Takaori-Kondo; N Kadowaki; T Kitawaki; T Hori; T Uchiyama

  JOURNAL OF VIROLOGY, Mar. 2003, Peer-reviewed

  
• Successful treatment of chronic myelogenous leukemia with extramedullary megakaryoblastic tumor by allogeneic bone marrow transplantation (from an unrelated donor)

  M. Jinnai; M. Hishizawa; T. Kitawaki; K. Imada; T. Ishikawa; H. Ohno; T. Uchiyama; T. Ohno

  [Zasshi] Journal. Nihon Naika Gakkai, 2002, Peer-reviewed

  
• Non-Hodgkin's lymphoma involving bilateral breasts

  T Kitawaki; N Yonetani; H Akasaka; T Akasaka; H Ohno; M Okuma

  INTERNAL MEDICINE, Mar. 1998, Peer-reviewed

  
• Changes in platelet demand in association with the spread of autologous peripheral blood progenitor cell transplantation

  Yasunori Ueda; Yasumasa Ikeda; Sayo Watanabe; Toshio Kitawaki; Fumio Matsuyama; Hiroshi Konishi; Yoshio Yagiri

  Therapeutic Apheresis, 1998, Peer-reviewed

  
• A proteasome inhibitor bortezomib suppresses immunostimulatory activity of human plasmacytoid dendritic cells by targeting intracellular trafficking of nucleic acid-sensing Toll-like receptors and endoplasmic reticulum homeostasis. Blood in press.

  Hirai M; N Kadowaki; T Kitawaki; H Fujita; A Takaori-Kondo; R Fukui; K Miyake; T Maeda; S Kamihira; Y Miyachi; T Uchiyama

  Peer-reviewed

  

Misc.

• Efficacy of Foscarnet in Preventing HHV6 Encephalitis in Adult Cord Blood Transplantation

  鈴木光太郎; 諫田淳也; 家村知樹; 新井康之; 渡邊瑞希; 島津裕; 北脇年雄; 水本智咲; 山下浩平; 高折晃史

  日本造血・免疫細胞療法学会総会プログラム・抄録集, 2024

  
• 【細胞治療の新時代】樹状細胞を利用した免疫療法

  門脇 則光; 北脇 年雄

  日本内科学会雑誌, Jul. 2019

  
• 【細胞治療とDDS-細胞を制御する、細胞で制御する-】白血病に対する細胞免疫療法

  門脇 則光; 北脇 年雄

  Drug Delivery System, Jan. 2013

  
• がん免疫療法における樹状細胞療法の展望

  北脇 年雄; 門脇 則光

  最新医学, Oct. 2010

  
• 【樹状細胞研究のトピックス】樹状細胞による細胞療法とその展開

  北脇 年雄; 門脇 則光

  炎症と免疫, Aug. 2010

  
• プロテアソーム阻害薬ボルテゾミブはヒト骨髄系樹状細胞および形質細胞様樹状細胞の機能を抑制する

  平井 麻起子; 門脇 則光; 北脇 年雄; 宮地 良樹; 内山 卓

  臨床血液, Sep. 2008

  
• プロテアソーム阻害薬ボルテゾミブはヒト骨髄系樹状細胞および形質細胞様樹状細胞の機能を抑制する

  平井 麻起子; 門脇 則光; 北脇 年雄; 宮地 良樹; 内山 卓

  基盤的癌免疫研究会総会抄録, Jun. 2008

  
• 【サイトカインの多彩な機能と臨床応用 免疫・造血・代謝・発生・神経の調節機構と疾患治療への最新アプローチ】サイトカインと疾患・臨床応用 樹状細胞の臨床応用 抗原特異的免疫制御療法の開発へむけて

  北脇 年雄; 門脇 則光

  実験医学, Dec. 2005

  
• I型インターフェロン産生細胞によるトレランスの誘導機構

  川村 和子; 門脇 則光; 北脇 年雄; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• 樹状細胞を用いたペプチド特異的T細胞の増幅とヘルパー抗原の効果

  北脇 年雄; 門脇 則光; 葛島 清隆; 内山 卓

  日本リンパ網内系学会会誌, Jun. 2004

  
• オプソニン化リポソームを用いたヒト樹状細胞への効率的な抗原ターゲティング法の開発

  川村 和子; 北脇 年雄; 門脇 則光; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• ヒト末梢単核球におけるGITR及びGITRリガンドの発現解析

  八木 治彦; 北脇 年雄; 門脇 則光; 内山 卓; 藤井 信吾; 坂口 志文

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• Clinical application of dendritic cells to tumor immunotherapy

  北脇 年雄; 門脇 則光

  最新医学, Nov. 2009

  
• 新たな指定難病と類縁疾患:リンパ増殖性疾患の鑑別診断と治療 キャッスルマン病

  川端 浩; 黒瀬 望; 藤本 信乃; 正木 康史; 古賀 智裕; 川上 純; 北脇 年雄; 高折 晃史; 吉藤 元; 三森 経世; 吉崎 和幸

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2019

  
• 新たな指定難病と類縁疾患:リンパ増殖性疾患の鑑別診断と治療 キャッスルマン病

  川端 浩; 黒瀬 望; 藤本 信乃; 正木 康史; 古賀 智裕; 川上 純; 北脇 年雄; 高折 晃史; 吉藤 元; 三森 経世; 吉崎 和幸

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2019

  
• Clinical Impact of Complex Karyotype, Monosomal Karyotype and Acquisition of Chromosomal Abnormalities in Patients with Myelodysplastic Syndromes

  June Takeda; Hiroshi Kawabata; Kazunari Aoki; Shuichi Shiga; Masahiro Kawahara; Toshio Kitawaki; Masakatsu Hishizawa; Tadakazu Kondo; Toshiyuki Kitano; Noboru Yonetani; Sumie Tabata; Nobuhiro Hiramoto; Akiko Matsushita; Hisako Hashimoto; Takayuki Ishikawa; Norimitsu Kadowaki; Akifumi Takaori-Kondo

  BLOOD, Dec. 2014

  
• Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs

  中村桃子; 中村桃子; 蝶名林和久; 蝶名林和久; 森本有紀; 森本有紀; 越智陽太郎; 越智陽太郎; 南谷泰仁; 北脇年雄; 菱澤方勝; 菱澤方勝; 小川誠司; 高折晃史; 吉田善紀

  日本血液学会学術集会抄録(Web), 2021

  
• Immunological effects of dasatinib in patients with chronic myeloid leukemia

  石山 賢一; 北脇 年雄

  血液内科 = Hematology, Sep. 2017

  
• X連鎖重症複合免疫不全症に合併したホジキン様EBV関連リンパ増殖性疾患の1例

  和田 典也; 中村 桃子; 近藤 忠一; 進藤 岳郎; 北脇 年雄; 菱澤 方勝; 山下 浩平; 高折 晃史; 井澤 和司; 八角 高裕

  臨床血液, Feb. 2020

  
• がん治療用HSV-1を用いた造血器腫瘍に対するウイルス療法

  石野 亮; 川瀬 有美; 北脇 年雄; 杉本 直志; 稲生 靖; 藤堂 具紀; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jul. 2019

  
• 中分子アゴニスト創薬のロジカルデザイン

  高折晃史; 北脇年雄; 永田崇

  第２回モダリティ創薬デザイン研究会, グランフロント大阪(大阪) 2018.11.26, Nov. 2018

  
• レナリドミドは骨髄系樹状細胞に作用して抗骨髄腫および抗炎症効果を発揮する(Lenalidomide performs anti-myeloma and anti-inflammatory function through acting on myeloid DCs)

  山本 和代; 北脇 年雄; 杉本 直志; 川瀬 有美; 末木 佑季; 藤田 晴之; 高折 晃史; 門脇 則光

  臨床血液, Sep. 2018

  
• 造血器腫瘍に対するHSV-1ウイルス療法の効果規定因子(A determining factor in efficacy of oncolytic virus therapy with HSV-1 for hematologic malignancies)

  石野 亮; 川瀬 有美; 北脇 年雄; 杉本 直志; 稲生 靖; 藤堂 具紀; 高折 晃史; 門脇 則光

  臨床血液, Sep. 2018

  
• 造血器腫瘍に対するHSV-1ウイルス療法の効果規定因子

  石野 亮; 川瀬 有美; 北脇 年雄; 杉本 直志; 稲生 靖; 藤堂 具紀; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jul. 2018

  
• 造血器腫瘍に対するHSV-1ウイルス療法の開発

  石野 亮; 川瀬 有美; 北脇 年雄; 杉本 直志; 稲生 靖; 藤堂 具紀; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jun. 2017

  
• Safety and efficacy of the immune checkpoint inhibitor ipilimumab in patients with relapse after allogeneic hematopoietic stem cell transplantation

  北脇 年雄

  血液内科 = Hematology, May 2017

  
• Principal component analysis uncovers cytomegalovirus-associated NK cell activation in Ph+ leukemia patients treated with dasatinib (vol 31, 203, 2017)

  K. Ishiyama; T. Kitawaki; N. Sugimoto; T. Sozu; N. Anzai; M. Okada; M. Nohgawa; K. Hatanaka; N. Arima; T. Ishikawa; S. Tabata; T. Onaka; S. Oka; Y. Nakabo; R. Amakawa; M. Matsui; T. Moriguchi; A. Takaori-Kondo; N. Kadowaki

  LEUKEMIA, Jan. 2017

  
• Expansion of Dysfunctional CD56-Negative NK Cells Is a Hallmark of NK Cell Activation in Ph+ Leukemia Patients Treated with Dasatinib

  Ken-ichi Ishiyama; Toshio Kitawaki; Naoshi Sugimoto; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  BLOOD, Dec. 2016

  
• Regeneration of Tumor Antigen Specific CTLs Utilizing iPSC Technology for Off-the-Shelf Immunotherapy

  Takuya Maeda; Seiji Nagano; Kyoko Masuda; Toshio Kitawaki; Keisuke Kataoka; Seishi Ogawa; Norimitsu Kadowaki; Akifumi Kondo Takaori; Hiroshi Kawamoto

  BLOOD, Dec. 2016

  
• REGENERATION OF WT1 SPECIFIC CTLS UTILIZING IPSC TECHNOLOGY

  T. Maeda; S. Nagano; K. Masuda; T. Kitawaki; A. Takaori-Kondo; H. Kawamoto

  HAEMATOLOGICA, Jun. 2016

  
• 造血器腫瘍に対するHSV-1ウイルス療法の開発

  石野 亮; 川瀬 有美; 北脇 年雄; 杉本 直志; 稲生 靖; 藤堂 具紀; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jun. 2016

  
• Regeneration of tumor antigen specific CTLs utilizing iPSC technology

  Takuya Maeda; Seiji Nagano; Hiroshi Ichise; Kyoko Masuda; Toshio Kitawaki; Akifumi Kondo-Takaori; Hiroshi Kawamoto

  CANCER IMMUNOLOGY RESEARCH, Jan. 2016

  
• Dendritic cell-based immunotherapy for leukemia

  門脇 則光; 北脇 年雄

  血液内科, Feb. 2015

  
• Expression of Tim-1 and Its Pathogenetic Role in Primary CNS Lymphoma

  Momoko Nishikori; Wataru Kishimoto; Hiroshi Arima; Kotaro Shirakawa; Toshio Kitawaki; Akifumi Takaori-Kondo

  BLOOD, Dec. 2014

  
• Dasatinib Expands Pre-Existing, CMV-Associated, Highly Differentiated NK Cells in Ph+ Leukemia

  Ken-ichi Ishiyama; Toshio Kitawaki; Akifumi Takaori; Norimitsu Kadowaki

  BLOOD, Dec. 2014

  
• ダサチニブ治療中のPh陽性白血病患者では高い細胞傷害活性を有するCMV関連NK細胞が増加する

  石山 賢一; 北脇 年雄; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jun. 2014

  
• 骨髄移植症例におけるドナー由来HLA抗体への対応

  YURUGI KIMIKO; MIURA YASUO; HISHIDA RIE; HIRAI HIDEYO; KITAWAKI TOSHIO; NISHIKORI MOMOKO; HISHIZAWA MASAKATSU; KONDO TADAKAZU; KITANO TOSHIYUKI; TAKAORI AKIFUMI; MAEKAWA TAIRA

  日本輸血細胞治療学会誌, 10 Apr. 2014

  
• 骨髄移植症例におけるドナー由来HLA抗体への対応

  YURUGI KIMIKO; MIURA YASUO; HISHIDA RIE; HIRAI HIDEYO; MAEKAWA TAIRA; KITAWAKI TOSHIO; NISHIKORI MOMOKO; HISHIZAWA KATAKATSU; KONDO TADAKAZU; KITANO TOSHIYUKI; TAKAORI AKIFUMI; ASHIHARA HIDEJI

  臨床血液, 28 Feb. 2014

  
• 【腫瘍免疫学とがん免疫療法 がんの進展・排除を司る免疫システムと逃避するがん-その制御による新たながん治療】(第I部)腫瘍免疫応答の制御法と基本 (第1章)腫瘍免疫における免疫担当細胞と免疫分子の役割 樹状細胞 腫瘍免疫制御のkey player

  北脇 年雄; 門脇 則光

  実験医学, Aug. 2013

  
• ビタミンD刺激によってレチノイン酸を高産生するヒト樹状細胞の同定

  佐藤 貴之; 北脇 年雄; 藤田 晴之; 岩田 誠; 伊豫田 智典; 稲葉 カヨ; 樗木 俊聡; 坂井 義治; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jul. 2013

  
• 【がん免疫学と免疫療法の新展開】造血器腫瘍に対する樹状細胞療法

  門脇 則光; 北脇 年雄

  血液フロンティア, Jul. 2012

  
• Clinical Application of Dendritic Cells to Cancer Immunotherapy : Clinical Trials of Dendritic Cell-Based Immunotherapy for Acute Myeloid Leukemia

  Kitawaki Toshio

  日本アフェレシス学会雑誌, 2012

  
• Novel Approach Toward Advanced Dendritic Cell Therapy ヒト樹状細胞の機能制御による悪性腫瘍および炎症性疾患の治療

  門脇 則光; 北脇 年雄; 平井 麻起子

  臨床血液, Jul. 2011

  
• 樹状細胞と免疫制御 免疫疾患の解明に向けた新たな展開 樹状細胞を用いた急性骨髄性白血病に対する新規免疫療法の開発

  北脇 年雄; 笠井 泰成; 前川 平; 前川 隆司; 近藤 隆重; 贄田 美江; 葛島 清隆; 門脇 則光

  Cytometry Research, Jun. 2011

  
• ABLキナーゼ阻害薬ダサチニブによるヒト形質細胞様樹状細胞の機能抑制

  藤田 晴之; 北脇 年雄; 内山 卓; 高折 晃史; 門脇 則光

  日本がん免疫学会総会プログラム・抄録集, Jun. 2011

  
• Protein Kinase Inhibitor Dasatinib Potently Suppresses Immunostimulatory Activity of Human Plasmacytoid Dendritic Cells

  Haryuki Fujita; Toshio Kitawaki; Takashi Uchiyama; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  BLOOD, Nov. 2010

  
• Idiopathic CD4 Lymphocytopenia Due to Loss of Heterozygosity of the Mutant CD2 Gene

  Masaharu Tashima; Momoko Nishikori; Toshio Kitawaki; Masakatsu Hishizawa; Taisuke Izumi; Yayoi Fujiwara; Minako Mori; Kaori Kihara; Katsuyuki Ohmori; Tadakazu Kondo; Takayuki Ishikawa; Akifumi Takaori-Kondo

  BLOOD, Nov. 2010

  
• ABLキナーゼ阻害薬ダサチニブによるヒト形質細胞様樹状細胞の機能制御

  藤田 晴之; 門脇 則光; 北脇 年雄; 内山 卓

  日本がん免疫学会総会プログラム・抄録集, Jul. 2010

  
• 【AML診療の新たな展開】AMLに対する免疫療法の現状と可能性

  北脇 年雄; 門脇 則光

  血液・腫瘍科, Apr. 2010

  
• 高齢者AMLに対する樹状細胞を用いた細胞免疫療法の臨床試験

  KITAWAKI TOSHIO; KADOWAKI NORIMITSU; FUKUNAGA KEIKO; UTSUMI MAKI; HIRAI MAKIKO; KASAI YASUNARI; MAEKAWA TAIRA; OMORI KATSUYUKI; ITO TATSUYA; SHIMIZU AKIRA; KUZUSHIMA KIYOTAKA; TAKAHARA MASASHI; NIETA MIE; MAEKAWA TAKASHI; ISHIKAWA TAKAYUKI; UCHIYAMA TAKASHI

  日本造血細胞移植学会総会プログラム・抄録集, 2010

  
• 樹状細胞 プロテアソーム阻害薬ボルテゾミブによるヒト樹状細胞における核酸認識TLRシグナルの抑制機構

  平井 麻起子; 門脇 則光; 北脇 年雄; 宮地 良樹; 内山 卓

  日本がん免疫学会総会プログラム・抄録集, Jun. 2009

  
• 樹状細胞 自己白血病細胞を貪食させた樹状細胞を用いた高齢者急性骨髄性白血病に対する細胞免疫療法の第I/IIa相臨床試験

  北脇 年雄; 門脇 則光; 福永 桂子; 内海 真紀; 平井 麻起子; 笠井 泰成; 前川 平; 大森 勝之; 伊藤 達也; 清水 章; 石川 隆之; 内山 卓

  日本がん免疫学会総会プログラム・抄録集, Jun. 2009

  
• 【がん免疫の基礎と臨床】樹状細胞を用いたがん免疫療法

  門脇 則光; 北脇 年雄

  臨床血液, May 2009

  
• 【がんの免疫療法の進歩と限界】樹状細胞を用いた造血器腫瘍に対する免疫療法

  北脇 年雄; 門脇 則光

  血液フロンティア, Mar. 2009

  
• B Cells with BCL2/IGH Translocation Compose a Distinctive Cell Population That May Serve as a Reservoir of Lymphoma of Germinal Center B-Cell Type

  Tomomi Sakai; Momoko Nishikori; Masaharu Tashima; Ryo Yamamoto; Toshio Kitawaki; Akifumi Takaori-Kondo; Shinobu Tsuzuki; Takashi Uchiyama

  BLOOD, Nov. 2008

  
• BCL2転座陽性B細胞の生理学的特徴と分化指向性の解析

  SAKAI TOMOMI; NISHIKIORI MOMOKO; TAJIMA MASAHARU; KITAWAKI TOSHIO; YAMAMOTO REI; TAKAORI AKIFUMI; UCHIYAMA TAKASHI

  臨床血液, 30 Sep. 2008

  
• 自己白血病細胞を貪食した樹状細胞による高齢者AMLに対する細胞免疫療法

  北脇 年雄; 門脇 則光; 福永 桂子; 平井 麻起子; 近藤 忠一; 笠井 泰成; 前川 平; 大森 勝之; 伊藤 達也; 多田 春江; 福島 雅典; 清水 章; 石川 隆之; 内山 卓

  臨床血液, Sep. 2008

  
• Characterizing biological features of B cells carrying BcL2/IGH translocation

  T. Sakai; M. Nishikori; T. Kitawaki; M. Tashima; R. Yamamoto; T. Uchiyama

  ANNALS OF ONCOLOGY, Jun. 2008

  
• A GATA-1-regulated microRNA cluster that is essential for erythropoiesis

  Ryo Yamamoto; Momoko Nishikori; Toshio Kitawaki; Tomomi Sakai; Masakatsti Hishizawa; Malsaharu Tashima; Tadakazu Kondo; Katsuyuki Ohmori; Takashi Uchiyama

  BLOOD, Nov. 2007

  
• PD-1/PD-1-ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma

  Ryo Yamamoto; Momoko Nishikori; Toshio Kitawaki; Tomomi Sakai; Masakatsti Hishizawa; Malsaharu Tashima; Tadakazu Kondo; Katsuyuki Ohmori; Takashi Uchiyama

  BLOOD, Nov. 2007

  
• CD70/CD27シグナルを介した、ヒト樹状細胞によるヘルパーT細胞の分化誘導(CD70/CD27 interaction potently enhances differentiation of naive CD4+ T cells into cytokine-producing effector T cells during the stimulation with dendritic cells)

  橋本 睦実; 北脇 年雄; 門脇 則光; 岩田 哲史; 森本 幾夫; 内山 卓

  日本免疫学会総会・学術集会記録, Oct. 2007

  
• BCL2転座陽性B細胞のマウス生体内における動態解析

  SAKAI TOMOMI; NISHIKIORI MOMOKO; YAMAMOTO REI; TAJIMA MASAHARU; KITAWAKI TOSHIO; UCHIYAMA TAKASHI

  臨床血液, 30 Sep. 2007

  
• 樹状細胞による刺激においてCD70シグナルはエフェクターCD4+T細胞を強力に誘導する

  橋本 睦実; 北脇 年雄; 門脇 則光; 岩田 哲史; 森本 幾夫; 内山 卓

  臨床血液, Sep. 2007

  
• 樹状細胞刺激時におけるCD4陽性T細胞のサイトカイン産生性エフェクターT細胞への分化のCD70/CD27相互作用による増強(CD70/CD27 interaction enhances differentiation of naive CD4+ T cells into cytokine-producing effector T cells during the stimulation with dendritic cells)

  橋本 睦実; 北脇 年雄; 門脇 則光; 内山 卓

  基盤的癌免疫研究会総会抄録, May 2007

  
• 同種造血幹細胞移植後の急性骨髄性白血病再発に対するWT1ペプチドパルス・ドナー由来樹状細胞療法

  北脇 年雄; 門脇 則光; 近藤 忠一; 川村 和子; 田端 淑恵; 石川 隆之; 一戸 辰夫; 笠井 泰成; 前川 平; 内山 卓

  臨床血液, Sep. 2006

  
• 樹状細胞の臨床応用 造血器腫瘍に対する樹状細胞療法

  門脇 則光; 北脇 年雄; 平井 麻起子; 川村 和子; 田端 淑恵; 福永 桂子; 笠井 泰成; 内田 百合香; 中川 陽子; 木村 晋也; 前川 平; 内山 卓

  日本リンパ網内系学会会誌, Jun. 2006

  
• ウイルス刺激を受けた形質細胞様樹状細胞によるCD4陽性細胞傷害性免疫抑制性T細胞の誘導

  川村 和子; 門脇 則光; 北脇 年雄; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• ウイルス刺激を受けた形質細胞様樹状細胞によるCD4陽性細胞傷害性免疫抑制性T細胞の誘導

  川村 和子; 門脇 則光; 北脇 年雄; 内山 卓

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005

  
• 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導

  北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005

  
• ウイルス刺激を受けた形質細胞様樹状細胞によるCD4陽性細胞傷害性免疫抑制性T細胞の誘導

  川村 和子; 門脇 則光; 北脇 年雄; 内山 卓

  日本リンパ網内系学会会誌, Jun. 2005

  
• 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導

  北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓

  日本リンパ網内系学会会誌, Jun. 2005

  
• 形質細胞様樹状細胞によるCD4陽性細胞傷害性免疫抑制性T細胞の誘導

  川村 和子; 門脇 則光; 北脇 年雄; 内山 卓

  基盤的癌免疫研究会総会抄録, Jun. 2005

  
• SR-PSOX/CXCL16とCXCR6の相互作用におけるヒトDCサブセットの機能

  田端 淑恵; 門脇 則光; 北脇 年雄; 島岡 猛士; 米原 伸; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• ヒト肥満細胞による樹状細胞の活性化とT細胞反応への影響

  北脇 年雄; 杉本 直志; 門脇 則光; 神戸 直智; 内山 卓

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• 抗原内封IgG-リポソームをパルスした樹状細胞による特異的抗腫瘍免疫の誘導

  宇田川 悟史; 笠岡 敏; 宇都口 直樹; 門脇 則光; 川村 和子; 北脇 年雄; 杉本 央; 丸山 一雄

  日本薬学会年会要旨集, Mar. 2004

  
• Depletion and dysfunction of blood plasmacytoid dendritic cells in human T-cell lymphotropic virus Type-I-infected individuals.

  M Hishizawa; K Imada; T Kitawaki; N Kadowaki; T Uchiyama

  BLOOD, Nov. 2003

  
• Compromised recovery of natural interferon-alpha/beta-producing cells after allogeneic hematopoietic stem cell transplantation complicated by acute graft versus host disease and glucocorticoid administration.

  T Kitawaki; N Kadowaki; T Ishikawa; T Ichinohe; T Uchiyama

  BLOOD, Nov. 2003

  
• Compromised recovery of natural interferon-alpha/beta-producing cells after allogeneic hematopoietic stem cell transplantation complicated by acute graft versus host disease and glucocorticoid administration

  T Kitawaki; N Kadowaki; T Ishikawa; T Ichinohe; T Uchiyama

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Nov. 2003

  
• c‐MYC,BCL2,BCL6転座を同時に認めたびまん性大細胞型B細胞リンパ腫(DLBCL)の遺伝子解析

  UEDA CHIYOKO; NISHIKORI MOMOKO; KITAWAKI TOSHIO; ONO HITOSHI; UCHIYAMA TAKASHI

  臨床血液, 30 Aug. 2003

  
• Natural interferon producing cells(IPC)とHIV-1の相互作用の解析

  森田 林平; 堀 利行; 米澤 明仁; 高折 晃史; 門脇 則光; 北脇 年雄; 内山 卓

  日本エイズ学会誌, Nov. 2002

  
• HTLV-1感染者におけるnatural type 1 interferon-producing cellsの解析

  菱澤 方勝; 上田 真紀; 古賀 光; 北脇 年雄; 門脇 則光; 今田 和典; 内山 卓

  日本癌学会総会記事, Oct. 2002

  
• Fcγレセプターを介するエンドサイトーシスを利用したヒト樹状細胞による腫瘍特異的T細胞の効率的誘導

  北脇 年雄; 門脇 則光; 内山 卓

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• 同種造血幹細胞移植後におけるI型インターフェロン産生細胞(IPC)の回復

  北脇 年雄; 門脇 則光; 石川 隆之; 一戸 辰夫; 内山 卓

  臨床血液, Aug. 2002

  
• HTLV-I感染者におけるblood dendritic cellsの解析

  菱澤 方勝; 上田 真紀; 古賀 光; 北脇 年雄; 門脇 則光; 今田 和典; 内山 卓

  臨床血液, Aug. 2002

  
• 末梢血pDC2(I型インターフェロン産生細胞)のHIV-1感染感受性とインターフェロン産生応答

  米澤 昭仁; 堀 利行; 高折 晃史; 門脇 則光; 北脇 年雄; 森田 林平; 内山 卓

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 末梢血樹状細胞サブセットにおけるHIV-1感染と免疫応答の相異

  米澤 昭仁; 堀 利行; 高折 晃史; 門脇 則光; 北脇 年雄; 森田 林平; 内山 卓

  日本エイズ学会誌, Nov. 2001

  
• Fludarabine+busulfan+200cGy TBIを前処置に用いた難治性・ハイリスク造血器腫ように対するミニ移植

  KITAWAKI TOSHIO; ICHINOHE TATSUO; HISHIZAWA NORIKATSU; NISHIHARA TOSHIO; UEDA MAKI; YAMADA HIROKO; KOBAYASHI MASAYUKI; NISHIKIORI MOMOKO; UCHIYAMA SUGURU

  臨床血液, 30 Oct. 2001

  
• CD14high及びCD14lowヒト末梢血単球亜群のToll-like receptor発現と樹状細胞への分化能の検討

  北脇 年雄; 門脇 則光; Ho Stephen; Antonenko Sventlana; Liu Yong-Jun; 内山 卓

  日本臨床免疫学会会誌, Oct. 2001

  
• ATG非使用レジメンによるミニトランスプラント後の免疫再構築過程の検討(Immune-reconstitution following non-myeloablative transplantation without pretransplant ATG)

  菱澤 方勝; 北脇 年雄; 門脇 則光; 今田 和典; 一戸 辰夫; 石川 隆之; 大野 仁嗣; 内山 卓

  International Journal of Hematology, Mar. 2001

  

Presentations

• 高齢者急性骨髄性白血病に対する樹状細胞療法

  第6回北海道血液・腫瘍カンファレンス, 16 Oct. 2009, 北海道血液・腫瘍カンファレンス

  

External funds: Kakenhi

• Phosphoproteomic analysis of IFN production mechanism by plasmacytoid dendritic cells

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49070:Immunology-related

  Kyoto University

  Toshio Kitawaki

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  形質細胞様樹状細胞;定量的リン酸化プロテオーム解析;インターフェロン・アルファ;チロシンキナーゼ阻害剤;トル様受容体9;インターフェロンα;自己免疫性疾患;自己免疫疾患;尋常性乾癬;インターフェロン;リン酸化プロテオーム解析;自然免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07605/
• Development of innovative therapy combining molecularly targeted drugs and immunotherapy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kitawaki Toshio

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  ダサチニブ;免疫チェックポイント阻害剤;NK細胞;サイトメガロウイルス;免疫チェックポイント阻害薬;分子標的薬;チロシンキナーゼ阻害剤;併用療法;PD-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461419/
• Comprehensive screening and identification of novel molecules involved in the spatiotemoral regulation of endosomes in plasmacytoid dendritic cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Toshio KITAWAKI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  自然免疫;形質細胞様樹状細胞;I型インターフェロン;二重レポーターシステム;エンドソーム;IRF7;レポーターシステム;DNAマイクロアレイ;DNAメチル化解析;レトロウイルス挿入変異;生体防御;分子メカニズム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790535/
• Proof-of-Concept Study of Combination Therapy of Epigenetics Regulation and Chemokine Receptor-Transduced CAR-T Cells

  Grant-in-Aid for Scientific Research (C)

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University

  北脇 年雄

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  CAR-T細胞療法;エピジェネティクス;ケモカイン受容体;B細胞リンパ腫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10451/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology II

  8031, Spring, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Hematology II

  8050, Fall, Faculty of Medicine, 1

Administration

Faculty management (title, position)

• From 01 Apr. 2013, To 31 Mar. 2015

  医学図書館図書連絡委員