Basic Information

Academic Degree

• 博士（理学）(兵庫県立大学)
• 修士（理学）(同志社大学)

Research History

• From Oct. 2021, To Present

  Kyoto University, バイオマスプロダクトツリー産学共同研究部門 （兼化学研究所 附属元素科学国際研究センター ）, 特定助教
• From Apr. 2018, To Mar. 2019

  日本学術振興会特別研究員DC2

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  202101000331026054

researchmap URL

• https://researchmap.jp/y.nakagawa

Research

Papers

• The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications.

  Shigeru Negi; Miki Imanishi; Mami Hamori; Yuka Kawahara-Nakagawa; Wataru Nomura; Kanae Kishi; Nobuhito Shibata; Yukio Sugiura

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Apr. 2023

  
• Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability

  Shigeru Negi; Mami Hamori; Yuka Kawahara-Nakagawa; Masato Mashimo; Miki Imanishi; Nozomi Kuki; Yuri Kawahito; Takayuki Manabe; Nobuyuki Kawamura; Jyunichiro Yasukawa; Hiroaki Kitagishi; Yukio Sugiura

  Chemistry Letters, 24 Dec. 2022

  
• Transpeptidation Reaction Mediated by Ligand- and Metal Cofactor-Substituted Sortase A from Staphylococcus aureus

  Shigeru Negi; Mami Hamori; Ayaka Sato; Kyoko Shimizu; Yuka Kawahara-Nakagawa; Takayuki Manabe; Nobuhito Shibata; Hiroaki Kitagishi; Masato Mashimo; Yukio Sugiura

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jul. 2022

  
• Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability.

  Shigeru Negi; Mami Hamori; Yuka Kawahara-Nakagawa; Miki Imanishi; Miku Kurehara; Chieri Kitada; Yuri Kawahito; Kanae Kishi; Takayuki Manabe; Nobuyuki Kawamura; Hiroaki Kitagishi; Masato Mashimo; Nobuhito Shibata; Yukio Sugiura

  RSC chemical biology, 03 Aug. 2022

  
• Fundamental electron-transfer and proton-coupled electron-transfer properties of Ru(iv)-oxo complexes.

  Hiroaki Kotani; Hinatsu Shimomura; Momoka Horimoto; Tomoya Ishizuka; Yoshihito Shiota; Kazunari Yoshizawa; Sachiko Yanagisawa; Yuka Kawahara-Nakagawa; Minoru Kubo; Takahiko Kojima

  Dalton transactions (Cambridge, England : 2003), 21 Sep. 2019

  
• New assay method based on Raman spectroscopy for enzymes reacting with gaseous substrates.

  Yuka Kawahara-Nakagawa; Koji Nishikawa; Satoru Nakashima; Shota Inoue; Takehiro Ohta; Takashi Ogura; Yasuteru Shigeta; Katsuyuki Fukutani; Tatsuhiko Yagi; Yoshiki Higuchi

  Protein science : a publication of the Protein Society, Mar. 2019

  
• Roles of carboxylate donors in O-O bond scission of peroxodi-iron(III) to high-spin oxodi-iron(IV) with a new carboxylate-containing dinucleating ligand

  Masahito Kodera; Tomokazu Tsuji; Tomohiro Yasunaga; Yuka Kawahara; Tomoya Hirano; Yutaka Hitomi; Takashi Nomura; Takashi Ogura; Yoshio Kobayashi; P. K. Sajith; Yoshihito Shiota; Kazunari Yoshizawa

  CHEMICAL SCIENCE, 2014

  
• Reversible O-O bond scission of peroxodiiron(III) to high-spin oxodiiron(IV) in dioxygen activation of a diiron center with a bis-tpa dinucleating ligand as a soluble methane monooxygenase model.

  Masahito Kodera; Yuka Kawahara; Yutaka Hitomi; Takashi Nomura; Takashi Ogura; Yoshio Kobayashi

  Journal of the American Chemical Society, 15 Aug. 2012

  

Misc.

• Deciphering the Molecular Mechanism Underlying Oxidation Reactions of Zinc Finger Proteins Using H₂O₂

  KISHI Kanae; HAMORI Mami; KAWAHARA-NAKAGAWA Yuka; SHIBATA Nobuhito; SUGIURA Yukio; NEGI Shigeru

  Peptide Science, 2021

  
• New Role of Biological Trace Metal Elements in Cooperative Protein Reduction by Glutathione and its Derivatives

  NEGI Shigeru; HASHIMOTO Rina; ITANI Yuka; KAWAHARA-NAKAGAWA Yuka; SUGIURA Yukio

  Peptide Science, 2021

  
• NEW ROLE OF BIOLOGICAL METAL IONS FOR THE COOPERATIVE REDUCTION OF PROTEIN BY GLUTATHIONE AND ITS DERIVETIVES

  NEGI Shigeru; HASHIMOTO Rina; KAWAHARA-NAKAGAWA Yuka; SUGIURA Yukio

  ペプチド討論会講演要旨集, 2020

  
• Development of inverse Raman micro spectroscopic system toward visualizing the dynamics of biomolecule in vivo and in cellulo

  KAWAHARA-NAKAGAWA Yuka; NAKASHIMA Satoru; OGURA Takashi

  生物物理(Web), 2017

  
• Involvement of trace metals in the reduction of disulfide bonds by glutathione

  Shigeru Negi; Mami Hamori; Rina Hashimoto; Yuka Nakagawa-Kawahara; Hiroaki Kitagishi; Yukio Sugiura

  30 Apr. 2022

  
• 高スピン二核鉄(IV)酸化活性種のsyn-anti構造変化による活性化:高いBDEをもつ強いC-H結合の活性化と非常に大きなKIE

  河原由佳

  Bulletin of Japan Society of Coordination Chemistry, 2014

  
• 6-hpa配位子のanti-dioxo high-spin diiron(IV)酸化活性種の生成と反応性:過酸化水素を酸化剤とする高効率高選択的アルカン水酸化

  石賀慎; 河原由佳; 辻朋和; 人見穣; 小寺政人

  錯体化学会討論会講演要旨集, 2014

  
• high spin(S=2)オキソ二核鉄(IV)錯体によるC-H活性化

  河原由佳; 人見穣; 小寺政人

  日本化学会講演予稿集, 2013

  
• カルボン酸含有二核化配位子(BPG₂E)を用いたパーオキソ二核鉄(III)錯体のO-O結合の開裂と基質酸化活性

  平野智也; 河原由佳; 人見穣; 小寺政人; 小林義男; 野村高志; 小倉尚志

  日本化学会講演予稿集, 2013

  
• 高スピン二核鉄(IV)酸化活性種のsyn-anti構造変化による活性化

  河原由佳; 人見穣; 小寺政人

  錯体化学会討論会講演要旨集, 2013

  
• 二核鉄錯体の酸素活性化に及ぼす電子効果: 6-hpa^R(R=4-OMe-3,5-Me₂or4-NO₂)二核化配位子を用いた二核鉄錯体の合成,結晶構造,及び酸素活性化

  日野彰大; 河原由佳; 人見穣; 小寺政人

  日本化学会講演予稿集, 2013

  
• 二核化配位子6-hpaの二核鉄錯体と過酸化水素の反応:パーオキソ二核鉄(III)からオキソ二核鉄(IV)酸化活性種への変換の分光学的追跡

  河原由佳; 野村高志; 小倉尚志; 小林義男; 人見穣; 小寺政人

  日本化学会講演予稿集, 2012

  
• 4つの電子供与性ペンダントピリジル基をもつbis-tpa型新規二核化配位子を用いた二核鉄錯体の合成

  葛尾昌晃; 入江寛彰; 河原由佳; 人見穣; 小寺政人

  日本化学会講演予稿集, 2012

  
• オキソ二核鉄(IV)high spin(S=2)錯体の反応性

  河原由佳; 野村高志; 小倉尚志; 小林義男; 人見穣; 小寺政人

  錯体化学会討論会講演要旨集, 2012

  
• オキソ二核鉄(IV)high spin(S=2)錯体の酸化反応活性

  河原由佳; 野村高志; 人見穣; 小林義男; 小倉尚志; 小寺政人

  酸化反応討論会講演要旨集, 2012

  
• 非ヘム二核鉄酸化酵素のcarboxylate-rich配位環境を模倣したカルボン酸含有二核化配位子(BPG₂E)を用いた二核鉄錯体による酸素活性化:パーオキソ二核鉄(III)およびオキソ二核鉄(IV)の生成と反応

  平野智也; 安永具弘; 河原由佳; 野村高志; 人見穣; 小林義男; 小倉尚志; 小寺政人

  酸化反応討論会講演要旨集, 2012

  
• 二核化配位子6-hpaの二核鉄錯体と過酸化水素の反応:パーオキソ二核鉄(III)から高原子価二核鉄(IV)酸化活性種への変換の検出

  河原由佳; 小林義男; 人見穣; 小寺政人

  酸化反応討論会講演要旨集, 2011