The Association of Anti-dsDNA Antibodies with Patient-reported Outcomes of Patients with Systemic Lupus Erythematosus in a Two-consecutive Year Prospective Study.
Positivity in serum MMP-3 after clinical remission or low disease activity at 52 weeks leads to future joint destruction in patients with rheumatoid arthritis
Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study.
Factors affecting discrepancies in disease activity evaluation between patients and physicians in systemic lupus erythematosus-The importance of symptoms such as fatigue.
Patient satisfaction with total joint replacement surgery for rheumatoid arthritis: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines
The influence of medial cuneiform inclination on postoperative hallux valgus recurrence in rheumatoid arthritis patients: Insights from the KURAMA cohort study.
Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort
Comparison of safety and effectiveness between etanercept biosimilar LBEC0101 and reference in patients with rheumatoid arthritis in real-world data using the KURAMA cohort.
Predictive value of baseline concomitant glucocorticoid for abatacept-mediated long-term inhibition of radiographic progression: insights from the KURAMA cohort.
Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort.
Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis
POS0354 IDENTIFICATION OF SOMATIC MUTATIONS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS
T. Iwasaki; K. Ohmura; C. Endo; M. Shirakashi; R. Hiwa; H. Tsuji; K. Kitagori; S. Akizuki; R. Nakashima; H. Yoshifuji; A. Morinobu; F. Matsuda; Y. Kamatani
Annals of the Rheumatic Diseases, 30 May 2023
POS0241 MONOCYTE-DERIVED TRANSCRIPTOMES EXPLAIN THE INEFFECTIVENESS OF ABATACEPT IN RHEUMATOID ARTHRITIS
T. Iwasaki; R. Watanabe; H. Ito; T. Fujii; K. Ohmura; H. Yoshitomi; K. Murata; K. Murakami; A. Onishi; M. Tanaka; S. Matsuda; F. Matsuda; A. Morinobu; M. Hashimoto
Annals of the Rheumatic Diseases, 30 May 2023
Impact of methotrexate on humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis.
How do symptoms of each joint contribute to global pain, disease activity and functional disability in rheumatoid arthritis?-A comprehensive association study using a large cohort.
Serum Concentrations of Infliximab and IL-6 for Predicting One-Year Discontinuation of Infliximab Treatment Owing to Secondary Non-response in Patients with Rheumatoid Arthritis.
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in a patient with anti-melanoma differentiation-associated gene 5-positive dermatomyositis: A case report and systematic literature review.
Efficacy of personalized exercise program on physical function in elderly patients with rheumatoid arthritis at high risk for sarcopenia: study protocol for a randomized controlled trial
Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis.
A new autoantibody to valyl transfer RNA synthetase associated with anti-synthetase syndrome.
Tsuneo Sasai; Ran Nakashima; Mirei Shirakashi; Ryosuke Hiwa; Hideaki Tsuji; Koji Kitagori; Shuji Akizuki; Hajime Yoshifuji; Tsuneyo Mimori; Akio Morinobu
Rheumatology (Oxford, England), 04 Oct. 2022
High plasma homocysteine level is associated with increased prevalence of non-remission state in rheumatoid arthritis: findings from the KURAMA cohort.
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.
Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation.
Non-Drug and Surgical Treatment Algorithm and Recommendations for the 2020 Update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis - Secondary Publication.
Drug Treatment Algorithm and Recommendations from the 2020 update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis-Secondary Publication.
Differential efficacy of TNF inhibitors with or without the immunoglobulin fragment crystallizable (Fc) portion in rheumatoid arthritis: the ANSWER cohort study.
Pain catastrophizing hinders Disease Activity Score 28 - erythrocyte sedimentation rate remission of rheumatoid arthritis in patients with normal C-reactive protein levels.
International journal of rheumatic diseases, Dec. 2021
Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study
Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study.
Y Nakayama; M Hashimoto; R Watanabe; K Murakami; K Murata; M Tanaka; H Ito; W Yamamoto; K Ebina; K Hata; Y Hiramatsu; M Katayama; Y Son; H Amuro; K Akashi; A Onishi; R Hara; K Yamamoto; K Ohmura; S Matsuda; A Morinobu
Scandinavian journal of rheumatology, 13 Sep. 2021, Peer-reviewed
Prevalence of anti-dense fine speckled 70 antibodies in healthy individuals and patients with antinuclear antibody-associated autoimmune rheumatic diseases in Japan.
Does exercise therapy improve patient-reported outcomes in rheumatoid arthritis? A systematic review and meta-analysis for the update of the 2020 JCR guidelines for the management of rheumatoid arthritis.
Patient satisfaction, preferences, expectations, characteristics, and impact of suboptimal control of rheumatoid arthritis: A subgroup analysis of Japanese patients from a large international cohort study (SENSE).
Predominant Involvement of the Aortic Root in a Patient with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: Congestive Heart Failure due to Subacute Severe Aortic Regurgitation and Reversible Conduction Disturbance.
Glucocorticoid-sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis.
International journal of rheumatic diseases, Oct. 2019, Peer-reviewed
Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study.
CD45RA-Foxp3(low) non-regulatory T cells in the CCR7-CD45RA-CD27+CD28+effector memory subset are increased in synovial fluid from patients with rheumatoid arthritis
GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients
J. Saegusa; Y. Irino; M. Yoshida; S. Tanaka; Y. Kogata; G. Kageyama; G. Tsuji; T. Takenawa; S. Kawano; S. Kumagai; A. Morinobu
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Jan. 2014, Peer-reviewed
CD45RA-Foxp3(high) activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28+central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis.
European journal of dermatology : EJD, 01 Apr. 2013, Peer-reviewed
Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study.
Diagnostic Accuracy of Serum 1,3-beta-D-Glucan for Pneumocystis jiroveci Pneumonia, Invasive Candidiasis, and Invasive Aspergillosis: Systematic Review and Meta-Analysis
Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population
Serum matrix metalloproteinase-3 as predictor of joint destruction in rheumatoid arthritis, treated with non-biological disease modifying anti-rheumatic drugs
Trichostatin a cooperates with fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts
A Morinobu; B Wang; J Liu; S Yoshiya; M Kurosaka; S Kumagai
JOURNAL OF RHEUMATOLOGY, Jun. 2006
Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis
S. Morinobu; A. Morinobu; S. Kanagawa; N. Hayashi; K. Nishimura; S. Kumagai
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, May 2006
A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary Sjogren's syndrome
T Imanishi; A Morinobu; N Hayashi; S Kanagawa; M Koshiba; S Kondo; S Kumagai
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Jul. 2005
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression.
Akio Morinobu; Yuka Kanno; John J O'Shea
The Journal of biological chemistry, 24 Sep. 2004, Peer-reviewed
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
Jay H Bream; Deborah L Hodge; Rivkah Gonsky; Rosanne Spolski; Warren J Leonard; Stephanie Krebs; Stephan Targan; Akio Morinobu; John J O'Shea; Howard A Young
The Journal of biological chemistry, 24 Sep. 2004, Peer-reviewed
N-acetyltransferase 2 genotype-related efficacy of Sulfasalazine in patients with rheumatoid arthritis
S Kumagai; F Komada; T Kita; A Morinobu; S Ozaki; H Ishida; H Sano; T Matsubara; K Okumura
PHARMACEUTICAL RESEARCH, Feb. 2004, Peer-reviewed
The biology of IL-12: coordinating innate and adaptive immune responses
WT Watford; M Moriguchi; A Morinobu; JJ O'Shea
CYTOKINE & GROWTH FACTOR REVIEWS, Oct. 2003
Characterization and analysis of the proximal Janus kinase 3 promoter.
Martin Aringer; Sigrun R Hofmann; David M Frucht; Min Chen; Michael Centola; Akio Morinobu; Roberta Visconti; Daniel L Kastner; Josef S Smolen; John J O'Shea
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.
Davide Agnello; Carla S R Lankford; Jay Bream; Akio Morinobu; Massimo Gadina; John J O'Shea; David M Frucht
Journal of clinical immunology, May 2003, Peer-reviewed
Association of the TAP2*Bky2 allele with presence of SS-A/Ro and other autoantibodies in Japanese patients with systemic lupus erythematosus
S Kanagawa; A Morinobu; M Koshiba; G Kageyama; N Hayashi; S Yoshino; Y Tokano; H Hashimoto; S Kumagai
LUPUS, 2003, Peer-reviewed
Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis
T Jikimoto; Y Nishikubo; M Koshiba; S Kanagawa; S Morinobu; A Morinobu; R Saura; K Mizuno; S Kondo; S Toyokuni; H Nakamura; J Yodoi; S Kumagai
MOLECULAR IMMUNOLOGY, Feb. 2002, Peer-reviewed
Polymorphisms of the mannose binding lectin gene in patients with Sjogren's syndrome
ZY Wang; A Morinobu; S Kanagawa; S Kumagai
ANNALS OF THE RHEUMATIC DISEASES, May 2001, Peer-reviewed
Bucillamine suppresses human Th1 cell development by a hydrogen peroxide-independent mechanism
A Morinobu; ZY Wang; S Kumagai
JOURNAL OF RHEUMATOLOGY, Apr. 2000, Peer-reviewed
A new allele of transporter associated with antigen processing gene (TAP2*Bky2) and glutathione S-transferase (GST) M1 homozygous null genotype were associated with anti-Ro/SS-A autoantibody production
S Kumagai; S Kanagawa; A Morinobu; M Koshiba; S Maekawa; N Hayashi; S Sugai; S Miyagawa
AUTOANTIGENS AND AUTOANTIBODIES: DIAGNOSTIC TOOLS AND CLUES TO UNDERSTANDING AUTOIMMUNITY, 2000, Peer-reviewed
Enzyme immunoassay by a mixture of a nuclear HEp-2 cell extract and recombinant proteins is equally or more useful than immunofluorescence assay for detection of antinuclear antibodies (ANA)
N Hayashi; T Kawamoto; M Mukai; A Morinobu; M Koshiba; S Kondo; S Kumagai
AUTOANTIGENS AND AUTOANTIBODIES: DIAGNOSTIC TOOLS AND CLUES TO UNDERSTANDING AUTOIMMUNITY, 2000, Peer-reviewed
Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjogren's syndrome in Japanese individuals
A Morinobu; S Kanagawa; M Koshiba; S Sugai; S Kumagai
ARTHRITIS AND RHEUMATISM, Dec. 1999, Peer-reviewed
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction
Sarpogrelate hydrochloride for Raynaud's phenomenon of patients with collagen diseases
S. Kumagai; A. Morinobu; S. Ozaki; K. Nakao; H. Ishida
Ryumachi, 1998, Peer-reviewed
Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val(577)), with susceptibility to Sjogren's syndrome
S Kumagai; S Kanagawa; A Morinobu; M Takada; K Nakamura; S Sugai; E Maruya; H Saji
ARTHRITIS AND RHEUMATISM, Sep. 1997, Peer-reviewed
IL-10 suppresses cell surface CD23/Fc epsilon RII expression, not by enhancing soluble CD23 release, but by reducing CD23 mRNA expression in human monocytes
A Morinobu; S Kumagai; H Yanagida; H Ota; H Ishida; M Matsui; J Yodoi; K Nakao
JOURNAL OF CLINICAL IMMUNOLOGY, Nov. 1996, Peer-reviewed
ENHANCED PRODUCTION OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) DURING AUTOLOGOUS MIXED LYMPHOCYTE-REACTION OF SYSTEMIC-SCLEROSIS PATIENTS
H OTA; S KUMAGAI; A MORINOBU; H YANAGIDA; K NAKAO
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Apr. 1995, Peer-reviewed
Misc.
Disease Duration Differentially Affects the Clinical Efficacy of Biologics and JAK Inhibitors in Rheumatoid Arthritis: The ANSWER Cohort Study
Genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a multicenter cohort study.
The Comparative Efficacy of Pneumocystis Pneumonia Prophylactic Regimens in Patients with Connective Tissue Diseases Receiving Prolonged High-dose Glucocorticoids
Kengo Akashi; Sadao Jinno; Akira Onishi; Mai Yamashita; Yoko Nose; Takaichi Okano; Yo Ueda; Sho Sendo; Jun Saegusa; Akio Morinobu
CD11b(+)Gr1(dim) tolerogenic dendritic dell-like cells are expanded in interstitial lung disease in SKG mice
Sho Sendo; Jun Saegusa; Hirotaka Yamada; Yoshihide Ichise; Ikuko Naka; Takaichi Okano; Soshi Takahashi; Yo Ueda; Kengo Akashi; Akio Morinobu
CYTOKINE, Dec. 2017
Inhibition of the Mechanistic Target of Rapamycin Pathway and Glutaminolysis Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG Mice
GLUTAMINE METABOLISM PLAYS A KEY ROLE IN THE CELL GROWTH OF FIBROBLAST-LIKE SYNOVIOCYTES IN RHEUMATOID ARTHRITIS
S. Takahashi; J. Saegusa; H. Yamada; Y. Ichise; I. Naka; T. Okano; K. Akashi; S. Sendo; Y. Ueda; A. Onishi; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2017
THE CLINICAL FEATURES OF 223 BEHCET'S DISEASE PATIENTS IN JAPAN
R. Saito; K. Nishimura; H. Mukoyama; Y. Nakamura; T. Nagamoto; K. Akashi; A. Onishi; Y. Kogata; J. Saegusa; A. Morinobu; T. Yokota
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2017
A LONGITUDINAL STUDY OF THE EFFECTS OF DISEASE ACTIVITY ON RENAL FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS UTILIZING LINEAR MIXED EFFECT MODELS - ANSWER COHORT STUDY
A. Onishi; K. Akashi; M. Hashimoto; M. Furu; W. Yamamoto; M. Katayama; R. Hara; T. Fujimura; S. Yoshida; K. Nagai; T. Hirano; K. Ebina; Y. Son; H. Amuro; H. Yamada; Y. Ichise; D. Waki; I. Naka; K. Tsuda; T. Okano; S. Takahashi; S. Sendo; Y. Ueda; Y. Kogata; J. Saegusa; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2017
RELIABILITY OF PATIENT GLOBAL ASSESSMENT IN RHEUMATOID ARTHRITIS PATIENTS
G. Kageyama; A. Onishi; Y. Ueda; J. Saegusa; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2017
CD11B(+)GR1DIM TOLEROGENIC DENDRITIC CELL-LIKE CELLS ARE EXPANDED IN INTERSTITIAL LUNG DISEASE IN SKG MICE
S. Sendo; J. Saegusa; Y. Ichise; H. Yamada; I. Naka; T. Okano; S. Takahashi; Y. Ueda; K. Akashi; A. Onishi; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2017
THE EFFICACY OF 2-YEARS DENOSUMAB TREATMENT FOR GLUCOCORTICOID-INDUCED OSTEOPOROSIS (GIOP)
K. Akashi; K. Nishimura; G. Kageyama; S. Ichikawa; T. Shirai; Y. Yamamoto; Y. Ichise; H. Yamada; I. Naka; D. Waki; T. Okano; S. Takahashi; Y. Ueda; S. Sendo; A. Onishi; J. Saegusa; A. Morinobu
CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice
Sho Sendo; Jun Saegusa; Takaichi Okano; Soshi Takahashi; Akio Morinobu
ARTHRITIS & RHEUMATOLOGY, Oct. 2016
Impact of Socioeconomic Status on Disease Outcomes in Japanese Patients with Rheumatoid Arthritis Under the Japanese National Insurance System
KNOCKOUT OF ENDOTHELIN TYPE B RECEPTOR SIGNALING ATTENUATES BLEOMYCIN-INDUCED SKIN SCLEROSIS IN MICE
K. Akashi; J. Saegusa; S. Sendo; K. Nishimura; K. Tsuda; I. Naka; T. Okano; S. Takahashi; M. Nishida; Y. Ueda; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2016
3-BROMOPYRUVATE AMELIORATES AUTOIMMUNE ARTHRITIS BY EXERTING A DUAL EFFECT ON BOTH TH17 AND TREG CELL DIFFERENTIATION AND DENDRITIC CELL ACTIVATION
T. Okano; J. Saegusa; K. Nishimura; S. Takahashi; S. Sendo; Y. Ueda; A. Onishi; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2016
SOME OF THE PAINFUL RA PATIENTS UNDERRATE GLOBAL HEALTH VAS AT HOSPITALS
G. Kageyama; A. Onishi; Y. Ueda; Y. Kamei; H. Yamada; Y. Ichise; D. Waki; I. Naka; K. Tsuda; T. Okano; S. Takahashi; M. Nishida; K. Akashi; K. Nishimura; S. Sendo; Y. Kogata; J. Saegusa; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2016
SUBJECTIVE WELL-BEING OF JAPANESE RA PATIENTS WHO REACH TREATMENT TARGET IS HIGHER THAN THE JAPANESE AVERAGE
G. Kageyama; A. Onishi; Y. Ueda; Y. Kamei; H. Yamada; Y. Ichise; D. Waki; I. Naka; K. Tsuda; T. Okano; S. Takahashi; M. Nishida; K. Akashi; K. Nishimura; S. Sendo; Y. Kogata; J. Saegusa; A. Morinobu
INEFFECTIVE FRACTURE PREVENTION BY BISPHOSPHONATE IN PATIENTS UNDERGOING HIGH DOSE GLUCOCORTICOID THERAPY WITH A FRAX TEN YEAR PROBABILITY GREATER THAN 5.8%
G. Kageyama; T. Okano; Y. Yamamoto; D. Sugiyama; G. Tsuji; K. Tsuda; S. Takahashi; M. Nishida; K. Akashi; K. Nishimura; S. Sendo; Y. Kogata; J. Saegusa; S. Kawano; S. Kumagai; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2014
SALIVARY METABOLOMICS OF PRIMARY SJOGREN'S SYNDROME
G. Kageyama; J. Saegusa; S. Tanaka; S. Takahashi; M. Nishida; K. Tsuda; Y. Yamamoto; T. Okano; K. Akashi; K. Nishimura; S. Sendo; Y. Kogata; S. Kawano; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2014
CD45RA-FOXP3LOW NON-REGULATORY T CELLS ARE INCREASED IN SYNOVIAL FLUID FROM PATIENTS WITH RHEUMATOID ARTHRITIS
J. Saegusa; F. Matsuki; K. Nishimura; Y. Miura; G. Kageyama; S. Kumagai; A. Morinobu
ANNALS OF THE RHEUMATIC DISEASES, Jun. 2014
GLUTAMATE AS A METABOLIC BIOMARKER FOR MONITORING DISEASE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUS
J. Saegusa; Y. Irino; M. Yoshida; S. Tanaka; Y. Kogata; G. Kageyama; G. Tsuji; S. Kawano; S. Kumagai; A. Morinobu
Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 5.8%.
Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions Of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients
Early Growth Response-1 (EGR-1) Controls Synoviocyte Apoptosis, and Its Expression Is Regulated by the Direct Binding of Fibroblast Growth Factor-1 (FGF1) or Insulin-Like Growth Factor-1 (IGF1) to Integrin alpha v beta 3
A Meta-Analysis: Diagnostic Accuracy of Serum Procalcitonin Concentrations for Detecting Systemic Bacterial Infection In Patients with Rheumatic Diseases.
The transcription factor Ets-1 is essential for janus kinase 3 (Jak3) promoter activity
M Aringer; S Hofmann; DM Frucht; C Min; M Centola; A Morinobu; R Visconti; H Haleem-Smith; DL Kastner; JS Smolen; JJ O'Shea
ARTHRITIS AND RHEUMATISM, Sep. 2002
Historic acetylation of interferon-gamma and T-bet genes during Th1 cell differentiation.
A Morinobu; JJ O'Shea
ARTHRITIS AND RHEUMATISM, Sep. 2002
STAT4 serine phosphorylation is critical for IL-12 induced IFN-gamma production and Th1 differentiation.
A Morinobu; M Gadina; R Visconti; GM Feldman; R Nishikomori; W Strober; JJ O'Shea
ARTHRITIS AND RHEUMATISM, Sep. 2001
Detection of antinuclear antibodies by use of an enzyme immunoassay with nuclear HEp-2 cell extract and recombinant antigens: Comparison with immunofluorescence assay in 307 patients
N Hayashi; T Kawamoto; M Mukai; A Morinobu; M Koshiba; S Kondo; S Maekawa; S Kumagai
CLINICAL CHEMISTRY, Sep. 2001
Down-regulation of alpha 6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc
H Fujimoto; Y Tanaka; ZJ Liu; H Yagita; K Okumura; A Kosugi; A Morinobu; H Umehara; H Yamamura; Y Minami
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice.
Sendo S; Saegusa J; Ichise Y; Yamada H; Naka I; Ueda Y; Okano T; Morinobu A
American College of Rheumatology 82nd Annual Scientific Meeting., Nov. 2018
Subjective well-being among rheumatoid arthritis patients.
Kageyama G; Onishi A; Ueda Y; Akashi Kengo; Sendo S; Saegusa J; Morinobu A
American College of Rheumatology 82nd Annual Scientific Meeting., Nov. 2018
Combined inhibition of mechanistic target of rapamycin and glutamine metabolism inhibits CD4 T cell proliferation and Th17 differentiation, facilitates the expansion of myeloid-derived suppressor cells, and synergistically ameliorates arthritis in SKG mic
Ueda Y; Saegusa J; Okano T; Sendo S; Yamada H; Yamada H; Onishi A; Morinobu A
American College of Rheumatology 82nd Annual Scientific Meeting., Nov. 2018
JAK阻害剤の基礎と臨床
MORINOBU AKIO
第27回日本シェーグレン症候群学会, Sep. 2018, Invited
The effects of trimethoprim-sulfamethoxazole on disease activity in patients with rheumatoid arthritis.
Onishi A; Akashi K; Hashimoto M; Yamamoto W; Murata K; Katayama M; Amuro H; Son Y; Yoshida S; Nagai K; Hara R; Ebina K; Hirano T; Yamamoto Y; Yamada H; Ichise Y; Naka I; Okano T; Takahashi S; Ueda Y; Sendo S; Saegusa J; Morinobu A
Annual European Congress of Rheumatology, Jun. 2018
Rapid elevation of erythrocyte methotrexate-polyglutamate3 (MTX-PG3) levels related to the efficacy of MTX in patients with rheumatoid arthritis (RA).
Nishida M; Tsuji G; Takahashi M; Saitou T; Noda Y; Yoneda K; Amano N; Sendo S; Onishi A; Morinobu A; Shinohara M; Kumagai S
Annual European Congress of Rheumatology, Jun. 2018
Tofacitinib Facilitate the Expansion of MDSCs and Suppress the Progression of Interstitial Lung Disease in SKG Mice.
Shou Sendou; Jun Saegusa; You Ueda; Ikuko Naka; Yoshihide Ichise; Hirotaka Yamada; Yuzuru Yamamoto; Akio Morinobu
第62回日本リウマチ学会総会・学術集会プログラム, Apr. 2018
The effects of trimethoprimsulfamethoxazole on disease activity in patients with RA - ANSWER longitudinal cohort study -
Onishi A; Akashi K; Hashimoto M; Yamamoto W; Murata K; Katayama M; Amuro H; Son Y; Yoshida S; Nagai K; Hara R; Ebina K; Hirano T; Yamamoto Y; Yamada H; Ichise Y; Naka I; Okano T; Takahashi S; Ueda Y; Sendo S; Jun Saegusa; Morinobu A
第62回日本リウマチ学会総会・学術集会プログラム, Apr. 2018
Inhibition of mTOR pathway and glutaminolysis facilitates the expansion of myeloidderived suppressor cells and synergistically ameliorates arthritis in SKG mice
Combined inhibition of mTOR and glutamine metabolism inhibits CD4+ T cell proliferation and Th17 differentiation, facilitates the expansion of myeloid-derived suppressor cells, and synergistically ameliorates arthritis in SKG mice.
Inhibition of the mTOR Pathway and Glutaminolysis Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG Mice.
CD11b+Grldim Tolerogenic Dendritic Cell-like Cells Differentiated from Monocytic-MDSCs Suppress the Progression of Interstitial Lung Disease in SKG Mice
Inhibition of mTOR pathway and glutaminolysis facilitates the expansion of myeloid-derived suppressor cells and synergistically ameliorates arthritis in SKG mice
ACR/ARHP Annual Meeting 2017, Nov. 2017, American Colleg of Rheumatology
SKGマウスの間質性肺炎ではユニークな免疫寛容性樹状細胞が誘導される
Saegusa Jun; Morinobu Akio
第4回JCRベーシックリサーチカンファレンス, Oct. 2017, 日本リウマチ学会
Inhibition of mTOR pathway and glutaminolysis facilitates the expansion of myeloid-derived suppressor cells and synergistically ameliorates arthritis in SKG mice
EULAR Congress 2017Annual European Congress of Rheumatology, Jun. 2017, European League Against Rheumatism
Subjective Well-being of Japanese RA patients who reach treatment target is higher than the Japanese average
Goichi Kageyama; Onishi Akira; Y. Ueda; Y. Kamei; Yamada Hideto; Y. Ichise; D. Waki; I. Naka; K. Tsuda; T. Okano; Takahashi Satoru; M. Nishida; Akashi Kengo; K. Nishimura; S. Sendo; Kogata Yoshinori; Saegusa Jun; Morinobu Akio
EULAR Congress 2016Annual European Congress of Rheumatology, Jun. 2017, European League Against Rheumatism
RELIABILITY OF PATIENT GLOBAL ASSESSMENT IN RHEUMATOID ARTHRITIS PATIENTS
G. kageyama; Onishi Akira; Y. Ueda; Saegusa Jun; Morinobu Akio
EULAR Congress 2017Annual European Congress of Rheumatology, Jun. 2017, European League Against Rheumatism
Longitudinal Study of The Effects of Disease Activity on Renal Function In Patients With Rheumatoid Arthritis Utilizing Linear Mixed Effect models - ANSWER Cohort Study -
Onishi Akira; Akashi Kengo; Hashimoto M; Furu M; Yamamoto W; Katayama M; Hara R; Fujimura T; Yoshida S; Nagai K; Hirano T; Ebina K; Son Y; Amuro H; Yamada Hideto; Ichise Y; Waki D; Naka I; Tsuda K; Okano T; Takahashi Satoru; Ueda Y; Kogata Y; Saegusa Jun; Morinobu Akio
EULAR Congress 2017Annual European Congress of Rheumatology, Jun. 2017, European League Against Rheumatism
CD11b+Grldim Tolerogenic Dendritic Cell-Like Cells are Expanded in Interstitial Lung Disease in SKG Mice
A longitudinal study of the effects of disease activity on renal function in patients with RA utilizing linear mixed effect models - ANSWER cohort study
CD11b+Gr1dim cells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice
Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 9.3%
European League Against Rheumatism 2014 Annual Meeting, Jun. 2014, 欧州リウマチ学会
Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 9.3%
The 42th Annual Meeting of The Japanese Society for Immunology, Dec. 2013, Japanese Society for Immunology
CD45RA-Foxp3high activated/effector regulatory T cells in the CCR7+CD45RA-CD27+CD28+ central memory subset are decreased in peripheral blood from patients with rheumatoid arthrits
Saegusa Jun; KUMAGAI Shunichi; Morinobu Akio
The 42th Annual Meeting of The Japanese Society for Immunology, Dec. 2013, Japanese Society for Immunology
サラゾスルファピリジン(SASP)単剤治療でde novo B型肝炎を来した関節リウマチ(RA)の1例
The 28th Annual Meeting of Japanese society for Clinical Rheumatology and Related Research, Nov. 2013, Japanese Society for Clinical Rheumatology and Related Research
The 41th Annual Meeting of the Japan Society for Clinical Immunology, Nov. 2013, The Japan Society for Clinical Immunology
Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients.
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
バイオマーカー・プロファイリングによる関節リウマチ新規診断法の検討
宇賀 均; 宮本 佳昭; 岡澤 貴裕; Morinobu Akio; 熊谷 俊一; 倉田 寛一
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2013, Japan College of Rheumatology
バイオマーカー・プロファイリングによる関節リウマチ新規診断法の検討
宇賀 均; 宮本 佳昭; 岡澤 貴裕; Morinobu Akio; 熊谷 俊一; 倉田 寛一
23rd Annual Meeting of The Society of Anaytical Bio-Science, Feb. 2013, The Society of Analytical Bio-Science
Regulatory and Pro-Inflammatory Properties of CD4+ T-Cell Subsets Defined by CD45RA, CCR7, CD27, and CD28 in Patients with Rheumatoid Arthritis
The 76th ACR/ARHP Annual Meeting, Nov. 2012, American College of Rheumatology
Early Growth Response-1(EGR-1)Controls Synoviocyte Apoptosis, and Its Expression is Regulated by the Direct Binding of Fibroblast Growth Factor-1(FGF1)or Insulin-Like Growth Factor-1(IGF1) to Integrin αvβ3.
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
The 57th Annual General Assembly and Schientific Meeting of the Japan College of Rheumatology The 22nd International Rheumatology Symposium, Apr. 2012, Japan College of Rheumatology
Trichostatin A Induces CD8a Positive Tolerogenic Dendritic Cells, Regulatory T Cells in SKG Mice, and Ameliorates the Severe Arthritis.
Misaki K; Morinobu Akio; Saegusa Jun; Kasagi S; Fujita M; Miyamoto Y; Matsuki F; Kumagai S
第75回アメリカリウマチ学会, Nov. 2011
Meta-Analysis:Diagnostic Accuracy of Serum Procalcitonin Concentrations for Detecting Systemic Bacterial Infection in Patients with Rheumatic Diseases.
Usage of High Sensitivity CRP Test Together with Anti-Ciclic Citrullinated Peptide Antibody Significantly Raised the Predictive Value for Rheumatoid Arthritis.
Diagnostic and Prognostic Accuracy of Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Early Rheumatoid Arthritis. A Meta-Analysis.
C321, Spring, Faculty of Pharmaceutical Sciences, 1
From 01 Apr. 2024, To 31 Mar. 2025
Allergic and Immune Disease
C009, Fall, Faculty of Medicine, 1
From 01 Apr. 2024, To 31 Mar. 2025
Immunology II
8031, Spring, Faculty of Medicine, 1
From 01 Apr. 2024, To 31 Mar. 2025
Clinical Overview of Medicine D
3226, Spring, Faculty of Medicine, 1
From 01 Apr. 2024, To 31 Mar. 2025
Pathophysiology
M044, Spring, Graduate School of Medicine, 2
From 01 Apr. 2023, To 31 Mar. 2024
Immunology II
8031, Spring, Faculty of Medicine, 1
From 01 Apr. 2023, To 31 Mar. 2024
Clinical Overview of Medicine D
3226, Spring, Faculty of Medicine, 1
From 01 Apr. 2023, To 31 Mar. 2024
Allergic and Immune Disease
C009, Fall, Faculty of Medicine, 1
From 01 Apr. 2023, To 31 Mar. 2024
Pathophysiology
M044, Spring, Graduate School of Medicine, 2
From 01 Apr. 2022, To 31 Mar. 2023
Immunology II
8031, Spring, Faculty of Medicine, 1
From 01 Apr. 2022, To 31 Mar. 2023
Allergic and Immune Disease
C009, Fall, Faculty of Medicine, 1
From 01 Apr. 2022, To 31 Mar. 2023
Clinical Overview of Medicine D
3226, Spring, Faculty of Medicine, 1
From Apr. 2021, To Mar. 2022
Allergic and Immune Disease
Fall, 医学部
From Apr. 2021, To Mar. 2022
Clinical Overview of Medicine D
Spring, 医学部(人間健康科学科)
Participation in PhD Defense
Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2
YOSHIDA SHIGEO, Graduate School of Medicine, Chief Examiner
24 Jul. 2023
Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease
HAMAKAWA YOKO, Graduate School of Medicine, Chief Examiner
23 May 2023
Diagnostic value of an algorithm for autoimmune epilepsy in a retrospective cohort
SAKAMOTO MITSUHIRO, Graduate School of Medicine, Chief Examiner
23 May 2023
PD-L1 on mast cells suppresses effector CD8+ T-cell activation in the skin in murine contact hypersensitivity
HIRANO TOMOKO, Graduate School of Medicine, Sub-chief Examiner
23 May 2023
Lung fibrogenic microenvironment in mouse reconstitutes human alveolar structure and lung tumor
MIYATA RYO, Graduate School of Medicine, Chief Examiner
23 Mar. 2023
A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties
KAMIO NAOKA, Graduate School of Medicine, Chief Examiner
23 Mar. 2023
Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways
YAMASAKI TOMOHIRO, Graduate School of Medicine, Chief Examiner
23 Mar. 2023
Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases
Tse Ka Man Carman, Graduate School of Medicine, Sub-chief Examiner
26 Sep. 2022
Circadian rhythm affects the magnitude of contact hypersensitivity response in mice
MIYAKE TOSHIYA, Graduate School of Medicine, Sub-chief Examiner
25 Jul. 2022
In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy
OKADA HIROKAZU, Graduate School of Medicine, Chief Examiner
25 Jul. 2022
Metabolic syndrome and comorbidities in psoriasis: A community-based case-control study from the Nagahama Cohort in Japan
ENDO YUICHIRO, Graduate School of Medicine, Sub-chief Examiner
23 Jan. 2023
Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross?sectional study
UDA MIYABI, Graduate School of Medicine, Sub-chief Examiner
26 Sep. 2022
Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation
NIHIRA HIROSHI, Graduate School of Medicine, Chief Examiner
23 Mar. 2022
STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T cell sensitivity to PD-1-dependent immunoregulation
WANG GUANNING, Graduate School of Medicine, Sub-chief Examiner
24 Jan. 2022
Specialized pro-resolving lipid meditators agonistic to formyl peptide receptor type 2 attenuate ischemia-reperfusion injury in rat lung
ODA HIROMI, Graduate School of Medicine, Sub-chief Examiner
23 Mar. 2022
Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis
KUWADA TAKESHI, Graduate School of Medicine, Chief Examiner
23 Mar. 2022
IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype
SUNADOME HIRONOBU, Graduate School of Medicine, Sub-chief Examiner
24 May 2021
Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids
ADACHI AKIMASA, Graduate School of Medicine, Chief Examiner
24 Sep. 2021
Glucocorticoids suppress fibroblast apoptosis in an in vitro thermal injury model
MATSUURA YOSHITAKA , Graduate School of Medicine, Sub-chief Examiner