Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 免疫生物学, 教授
• Graduate School of Medicine, 医科学専攻 免疫生物学, 教授

Faculty

• 医学部

Concurrent Affiliation

• Open Innovation Institute, 研究代表者

Professional Memberships

• 日本胸腺研究会
• 抗加齢医学会
• 日本細胞生物学会
• THE JAPANESE SOCIETY FOR IMMUNOLOGY

Academic Degree

• 修士（医科学）(筑波大学)
• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  200901086676909214

researchmap URL

• https://researchmap.jp/read0112983

Research

Research Topics, Overview of the research

• Research Topics

  1. Development and functions of supporting cells for lymphohematopoietic tissues such as thymic epithelial cells, which play a central role in the differentiation and selection of T cells.
  2. Induction of thymic epithelial cells from iPS cells and reconstruction of thymic functions.
  3. Mechanisms of thymic involution and activation of thymic functions.
  4. Mechanism of immunosenescence and its association with age-related diseases.
  5. Understanding and regulation of the human immune system.

• Overview of the research

  The immune system protects our bodies against infectious diseases caused by pathogens. At the same time, it is responsible for immune rejection that occurs when organs are transplanted into a human body and is involved in the onset and pathology of various age-related diseases including cancers and lifestyle diseases.
  Our laboratory studies the development and function of T cells, which act as the conductor of the immune system, and the thymic tissues, which is crucial for the differentiation and selection of T cells. We will strive to explore the fundamental principles of immunology and develop strategies for controlling immune reactions in order to advance medicine and medical applications.
  

Research Interests

• iPS細胞
• 老化
• 免疫老化
• Ｔ細胞
• 胸腺
• ワクチン
• ヒト免疫
• 上皮細胞

Research Areas

• Life sciences, Immunology

Papers

• CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

  Yuki Sato; Akiko Oguchi; Yuji Fukushima; Kyoko Masuda; Naoya Toriu; Keisuke Taniguchi; Takahisa Yoshikawa; Xiaotong Cui; Makiko Kondo; Takeshi Hosoi; Shota Komidori; Yoko Shimizu; Harumi Fujita; Li Jiang; Yingyi Kong; Takashi Yamanashi; Jun Seita; Takuya Yamamoto; Shinya Toyokuni; Yoko Hamazaki; Masakazu Hattori; Yasunobu Yoshikai; Peter Boor; Jürgen Floege; Hiroshi Kawamoto; Yasuhiro Murakawa; Nagahiro Minato; Motoko Yanagita

  The Journal of clinical investigation, 18 Jan. 2022

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• Intravital Imaging Identifies the VEGF-TXA2 Axis as a Critical Promoter of PGE2 Secretion from Tumor Cells and Immune Evasion.

  Yoshinobu Konishi; Hiroshi Ichise; Tetsuya Watabe; Choji Oki; Shinya Tsukiji; Yoko Hamazaki; Yasuhiro Murakawa; Akifumi Takaori-Kondo; Kenta Terai; Michiyuki Matsuda

  Cancer research, 01 Aug. 2021

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• Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner.

  Takeshi Ito; Kohei Kometani; Nagahiro Minato; Yoko Hamazaki

  Journal of immunology (Baltimore, Md. : 1950), 15 Oct. 2020

  
• Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export.

  Takahiro Nagatake; Zhao Yan-Chun; Takeshi Ito; Masahiko Itoh; Kohei Kometani; Mikio Furuse; Azusa Saika; Eri Node; Jun Kunisawa; Nagahiro Minato; Yoko Hamazaki

  International immunology, 10 Oct. 2020

  
• Physiology and pathology of T-cell aging.

  Nagahiro Minato; Masakazu Hattori; Yoko Hamazaki

  International immunology, 22 Jan. 2020, Peer-reviewed

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• Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets.

  Hongtu Li; Abraham Neelankal John; Takahiro Nagatake; Yoko Hamazaki; Fang-Xu Jiang

  FEBS open bio, Jan. 2020, Peer-reviewed

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• Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer.

  Shojiro Kikuchi; Kazuma Noguchi; Keiko Wakai; Yoko Hamazaki; Katsuyuki Tozawa; Takahito Jomori; Mitsuru Sasako; Hiroto Miwa

  Anticancer research, Sep. 2019, Peer-reviewed

  
• Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis.

  Imai T; Tanaka H; Hamazaki Y; Minato N

  Cancer Sci., Apr. 2019, Peer-reviewed

  
• An improved clonogenic culture method for thymic epithelial cells.

  Sekai M; Wang J; Minato N; Hamazaki Y

  J Immunol Methods., Apr. 2019, Peer-reviewed

  
• Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

  Jianwei Wang; Miho Sekai; Takeshi Matsui; Yosuke Fujii; Mitsuru Matsumoto; Osamu Takeuchi; Nagahiro Minato; Yoko Hamazaki

  International Immunology, 05 Mar. 2019, Peer-reviewed

  
• Clonogenic Culture of Mouse Thymic Epithelial Cells.

  Sekai M; Wang J; Hamazaki Y

  Methods Mol Biol., 2019, Peer-reviewed, Invited

  
• Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

  Hidehiko Suzuki; Takahiro Nagatake; Ayaka Nasu; Huangwenxian Lan; Koji Ikegami; Mitsutoshi Setou; Yoko Hamazaki; Hiroshi Kiyono; Kiyohito Yagi; Masuo Kondoh; Jun Kunisawa

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

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• Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility.

  Konishi Y; Terai K; Furuta Y; Kiyonari H; Abe T; Ueda Y; Kinashi T; Hamazaki Y; Takaori-Kondo A; Matsuda M

  iScience, Nov. 2018, Peer-reviewed

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• Combined effects of neoadjuvant letrozole and zoledronic acid on γδT cells in postmenopausal women with early-stage breast cancer

  Tomoharu Sugie; Eiji Suzuki; Akira Yamauchi; Kazuhiko Yamagami; Norikazu Masuda; Naomi Gondo; Eriko Sumi; Takafumi Ikeda; Harue Tada; Ryuji Uozumi; Shotaro Kanao; Yoshimasa Tanaka; Yoko Hamazaki; Nagahiro Minato; Masakazu Toi

  Breast, 01 Apr. 2018, Peer-reviewed

  
• CXCR3high CD8+ T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation.

  Kato A; Takaori-Kondo A; Minato N; Hamazaki Y

  Eur J Immunol. [Epub ahead of print], 2018, Peer-reviewed

  
• Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4(+) T Cells

  Kyosuke Sato; Aiko Kato; Miho Sekai; Yoko Hamazaki; Nagahiro Minato

  JOURNAL OF IMMUNOLOGY, Jul. 2017, Peer-reviewed

  
• A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.

  Ohigashi I; Ohte Y; Setoh K; Nakase H; Maekawa A; Kiyonari H; Hamazaki Y; Sekai M; Sudo T; Tabara Y; Sawai H; Omae Y; Yuliwulandari R; Tanaka Y; Mizokami M; Inoue H; Kasahara M; Minato N; Tokunaga K; Tanaka K; Matsuda F; Murata S; Takahama Y

  JCI insight, May 2017, Peer-reviewed

  
• Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin

  Takeshi Ito; Yoko Hamazaki; Akifumi Takaori-Kondo; Nagahiro Minato

  Cell Structure and Function, 2017, Peer-reviewed

  
• The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.

  Koyu Ito; Akira Nakajima; Yuji Fukushima; Keiichiro Suzuki; Keiko Sakamoto; Yoko Hamazaki; Kouetsu Ogasawara; Nagahiro Minato; Masakazu Hattori

  PloS one, 2017, Peer-reviewed

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• Obesity accelerates T cell senescence in murine visceral adipose tissue

  Kohsuke Shirakawa; Xiaoxiang Yan; Ken Shinmura; Jin Endo; Masaharu Kataoka; Yoshinori Katsumata; Tsunehisa Yamamoto; Atsushi Anzai; Sarasa Isobe; Naohiro Yoshida; Hiroshi Itoh; Ichiro Manabe; Miho Sekai; Yoko Hamazaki; Keiichi Fukuda; Nagahiro Minato; Motoaki Sano

  JOURNAL OF CLINICAL INVESTIGATION, Dec. 2016, Peer-reviewed

  
• Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

  Yuki Sato; Akiko Mii; Yoko Hamazaki; Harumi Fujita; Hirosuke Nakata; Kyoko Masuda; Shingo Nishiyama; Shinsuke Shibuya; Hironori Haga; Osamu Ogawa; Akira Shimizu; Shuh Narumiya; Tsuneyasu Kaisho; Makoto Arita; Masashi Yanagisawa; Masayuki Miyasaka; Kumar Sharma; Nagahiro Minato; Hiroshi Kawamoto; Motoko Yanagita

  JCI insight, 21 Jul. 2016, Peer-reviewed

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• Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution

  Yoko Hamazaki; Miho Sekai; Nagahiro Minato

  IMMUNOLOGICAL REVIEWS, May 2016, Peer-reviewed, Invited

  
• Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors

  Song Baik; Miho Sekai; Yoko Hamazaki; William E. Jenkinson; Graham Anderson

  EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2016, Peer-reviewed

  
• Adult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenance

  Yoko Hamazaki

  EUROPEAN JOURNAL OF IMMUNOLOGY, Nov. 2015, Peer-reviewed

  
• Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors

  Izumi Ohigashi; Saulius Zuklys; Mie Sakata; Carlos E. Mayer; Yoko Hamazaki; Nagahiro Minato; Georg A. Hollander; Yousuke Takahama

  CELL REPORTS, Nov. 2015, Peer-reviewed

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• A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

  Suhail Tahir; Yuji Fukushima; Keiko Sakamoto; Kyosuke Sato; Harumi Fujita; Joe Inoue; Toshimitsu Uede; Yoko Hamazaki; Masakazu Hattori; Nagahiro Minato

  JOURNAL OF IMMUNOLOGY, Jun. 2015, Peer-reviewed

  
• Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia

  Keiko Doi; Takahiko Imai; Christopher Kressler; Hideo Yagita; Yasutoshi Agata; Marc Vooijs; Yoko Hamazaki; Joe Inoue; Nagahiro Minato

  SCIENTIFIC REPORTS, Jan. 2015, Peer-reviewed

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• Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance

  Miho Sekai; Yoko Hamazaki; Nagahiro Minato

  IMMUNITY, Nov. 2014, Peer-reviewed

  
• In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

  Rei Mizuno; Yuji Kamioka; Kenji Kabashima; Masamichi Imajo; Kenta Sumiyama; Eiji Nakasho; Takeshi Ito; Yoko Hamazaki; Yoshihisa Okuchi; Yoshiharu Sakai; Etsuko Kiyokawa; Michiyuki Matsuda

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2014, Peer-reviewed

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• Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine

  Takahiro Nagatake; Harumi Fujita; Nagahiro Minato; Yoko Hamazaki

  PLOS ONE, Mar. 2014, Peer-reviewed

  
• Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis

  Harumi Fujita; Yoko Hamazaki; Yumi Noda; Masanobu Oshima; Nagahiro Minato

  PLOS ONE, Dec. 2012, Peer-reviewed

  
• 細胞接着・細胞外基質・細胞間相互作用 E-proteinによる胸腺内T細胞におけるクローディンの発現誘導とそのT細胞受容体シグナルにおける役割(Cell adhesion/ ECM/ Cell-cell interaction Claudin-4 induction by E-protein activity in thymic lymphocytes and its role in the TCR-mediated signaling)

  藤田 春美; 河合 洋平; 藤田 秋一; 藤本 豊士; 古瀬 幹夫; 縣 保年; 湊 長博; 濱崎 洋子

  日本細胞生物学会大会講演要旨集, May 2011

  
• Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency

  Hiroki Tanaka; Akitoshi Tamura; Miho Sekai; Yoko Hamazaki; Nagahiro Minato

  CANCER SCIENCE, Apr. 2011, Peer-reviewed

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• SPA-1 controls the invasion and metastasis of human prostate cancer

  Yosuke Shimizu; Yoko Hamazaki; Masakazu Hattori; Keiko Doi; Naoki Terada; Takashi Kobayashi; Yoshinobu Toda; Toshinari Yamasaki; Takahiro Inoue; Yoichiro Kajita; Atsushi Maeno; Tomomi Kamba; Yoshiki Mikami; Toshiyuki Kamoto; Tomomi Yamada; Toru Kanno; Kiyotsugu Yoshikawa; Osamu Ogawa; Nagahiro Minato; Eijiro Nakamura

  CANCER SCIENCE, Apr. 2011, Peer-reviewed

  
• Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency

  Kawai, Y; Hamazaki, Y; Fujita, H; Fujita, A; Sato, T; Furuse, M; Fujimoto, T; Jetten, A. M; Agata, Y; Minato, N

  Proc Natl Acad Sci U S A, 08 Mar. 2011, Peer-reviewed

  
• PD-1(+) memory phenotype CD4(+) T cells expressing C/EBP alpha underlie T cell immunodepression in senescence and leukemia

  Kenichiro Shimatani; Yasuhiro Nakashima; Masakazu Hattori; Yoko Hamazaki; Nagahiro Minato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2009, Peer-reviewed

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• Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells

  Yoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro Minato

  BLOOD, Aug. 2009, Peer-reviewed

  
• Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins

  Makoto Adachi; Yoko Hamazaki; Yuka Kobayashi; Masahiko Itoh; Sachiko Tsukita; Mikio Furuse; Shoichiro Tsukita

  MOLECULAR AND CELLULAR BIOLOGY, May 2009, Peer-reviewed

  
• Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1

  Daiji Sakata; Hiroyuki Taniguchi; Shingo Yasuda; Aki Adachi-Morishima; Yoko Hamazaki; Rika Nakayama; Takashi Miki; Nagahiro Minato; Shuh Narumiya

  JOURNAL OF EXPERIMENTAL MEDICINE, Sep. 2007, Peer-reviewed

  
• Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties

  Yuko Sugihara-Mizuno; Makoto Adachi; Yuka Kobayashi; Yoko Hamazaki; Miyuki Nishimura; Toshio Imai; Mikio Furuse; Shoichiro Tsukita

  GENES TO CELLS, Apr. 2007, Peer-reviewed

  
• Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

  Yoko Hamazaki; Harumi Fujita; Takashi Kobayashi; Yongwon Choi; Hamish S. Scott; Mitsuru Matsumoto; Nagahiro Minato

  NATURE IMMUNOLOGY, Mar. 2007, Peer-reviewed

  
• Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells

  D Ishida; L Su; A Tamura; Y Katayama; Y Kawai; SF Wang; M Taniwaki; Y Hamazaki; M Hattori; N Minato

  IMMUNITY, Apr. 2006, Peer-reviewed

  
• Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin

  M Harazaki; Y Kawai; L Su; Y Hamazaki; T Nakahata; N Minato; M Hattori

  IMMUNOLOGY LETTERS, Apr. 2004, Peer-reviewed

  
• Spa-1分子によるB1細胞機能制御

  石田 大輔; 米谷 耕平; 浜崎 洋子; 服部 雅一; 湊 長博

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• 【細胞の接着と極性形成】タイトジャンクションの膜裏打ち領域と上皮細胞極性

  濱崎 洋子; 古瀬 幹夫

  実験医学, Mar. 2003

  
• Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule

  Y Hamazaki; M Itoh; H Sasaki; M Furuse; S Tsukita

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2002, Peer-reviewed

  
• タイトジャンクションの接着分子クローディンと結合する13個のPDZドメインを持つ新規裏打ち蛋白質の同定

  浜崎 洋子; 伊藤 雅彦; 古瀬 幹夫; 月田 承一郎

  日本細胞生物学会大会講演要旨集, Aug. 2000

  
• Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets

  Y Hamazaki; H Kojima; H Mano; Y Nagata; K Todokoro; T Abe; T Nagasawa

  ONCOGENE, May 1998, Peer-reviewed

  
• Modulation of platelet activation in vitro by thrombopoietin

  H Kojima; Y Hamazaki; Y Nagata; K Todokoro; T Nagasawa; T Abe

  THROMBOSIS AND HAEMOSTASIS, Dec. 1995, Peer-reviewed

  
• Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals

  Norihide Jo; Rui Zhang; Hideki Ueno; Takuya Yamamoto; Daniela Weiskopf; Miki Nagao; Shinya Yamanaka; Yoko Hamazaki

  Frontiers in Aging, 10 Aug. 2021, Peer-reviewed, Corresponding author

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Presentations

• The Impact of Aging on SARS-CoV-2 Reactive T Cells

  Yoko Hamazaki

  Cold Spring Harbor Lab meeting COVID/SARS CoV2 Rapid Research Reports #5, 27 Jan. 2021, Invited

  
• T cell aging due to thymic involution

  Yoko Hamazaki

  日本分子生物学会 国際シンポジウム T cell aging and exhaustion: from a perspective of metabolism/細胞の老化と疲弊：代謝制御の観点から, 04 Dec. 2020, Invited

  
• 免疫応答 ウイルスから老化まで ―Ｔ細胞を中心に―

  濱崎 洋子

  日本抗加齢医学会 専門医・指導士認定委員会講習会, 15 Nov. 2020, Invited

  
• なぜ免疫は老化するのか？ その仕組みの理解と再生を目指して

  濱崎 洋子

  国際ソロプチミスト京都みやこ様 寄付金贈呈式, 10 Feb. 2020, Invited

  
• なぜ免疫は老化するのか？ その機構と再生 Ｔ細胞の産生臓器胸腺を中心に

  濱崎 洋子

  岡山経済同友会 １月定例幹事会兼地域振興委員会特別例会, 31 Jan. 2020, 岡山経済同友会, Invited

  
• Impacts of thymic involution on T cell aging and immunosenescence

  Yoko Hamazaki

  RIKEN Annual Aginf Project Meeting 2020, 20 Jan. 2020, 理化学研究所, Invited

  
• Road to the rejuvenation and reconstitution of the thymic microenvironment

  Yoko Hamazaki

  The 48th Annual Meeting of the Japanese Society for Immunology, 13 Dec. 2019, Invited

  
• 中学生時代から京都大学iPS細胞研究所(CiRA)まで

  濱崎 洋子

  JST平成31年度女子中高生の理系進路選択支援プログラム リケジョ合宿 in サンレイク, 12 Oct. 2019, Invited

  
• Ｔ細胞の発生と機能、そして老化

  濵﨑 洋子

  第35回西宮市ライフサイエンスセミナー 総合テーマ「免疫のライフサイエンス～最近の話題と免疫疾患～」, 25 Sep. 2019, Invited

  
• T cell aging due to thymic involution: role in immunosenescence and possible interventions

  HAMAZAKI Yoko

  France - Japan Symposium "Implications of Senescence in Age Related Disorders : Towards Healthy Aging", 05 Sep. 2019, Invited

  
• Thymic involution and T-cell aging

  HAMAZAKI Yoko

  本庶研究室リトリート, 24 May 2019, Invited

  
• Ｔ細胞の学校「胸腺」の謎にせまる そして学校をつくる？

  濵﨑 洋子

  サイエンスカフェ 聞かせて先生！CiRAの研究のお話, 26 Mar. 2019, Invited

  
• 胸腺退縮とＴ細胞老化

  濵﨑 洋子

  第51回ヒューマンサイエンス総合研究セミナー, 16 Jan. 2019

  
• 免疫システムの形成と破綻そして再構築－Ｔ細胞とその産生臓器 胸腺組織を中心に―

  濵﨑 洋子

  大阪市立大学 大学院セミナー, 20 Nov. 2018, Invited

  
• 自己と非自己を見分ける免疫の仕組みと加齢変化

  濵﨑 洋子

  京都大学丸の内セミナー（第９９回）, 05 Oct. 2018, Invited

  
• 1からわかる！iPS細胞

  濵﨑 洋子

  NHK文化センター 京都教室, 27 Jul. 2018, Invited

  
• 胸腺退縮と免疫老化

  濵﨑 洋子

  千里ライフサイエンスセミナーM1「老化メカニズムと疾患制御」, 30 May 2018, Invited

  
• 胸腺退縮とT細胞老化

  濵﨑 洋子

  第18回日本抗加齢医学会総会 シンポジウム 免疫⽼化の最前線, 25 May 2018, Invited

  
• Thymic involution and immunosenescence

  HAMAZAKI Yoko

  “Cutting Edge of Aging Research ~ Integrated Circuit of Inflammation, Immunity and Cognitive Function~”, 03 Feb. 2018

  
• Impacts of thymic involution on peripheral T cell gomeostasis and immunosenescence

  HAMAZAKI Yoko

  Leibniz-AMED Workshop on Immune Regulation of Disease and Aging, 09 Sep. 2017, AMED, Invited

  
• 免疫寛容とステルス性

  濵﨑 洋子

  第１回 免疫ステルス公開シンポジウム, 18 Aug. 2017, Invited

  
• Innate immune cell recruitment and activation by Hassall’s corpuscles in the thymic medulla: Implications of “sterile inflammation” on T-cell development

  HAMAZAKI Yoko

  The RIKEN IMS-JSI International Symposium on Immunology 2017 “Decoding Immune Complexity from Cell to System”, 23 Jun. 2017, Japanease Society for Immunology, RIKEN-IMS, Invited

  
• 中枢性自己寛容を保証する胸腺髄質上皮細胞の発生と機能に関する研究

  濵﨑 洋子

  花王科学賞 受賞講演, 16 Jun. 2017, 花王 芸術・科学財団, Invited

  
• ハッサル小体が関与する胸腺内好中球活性化とその意義

  濵﨑 洋子

  第３６回日本胸腺研究会, 04 Feb. 2017, 特定非営利活動法人 日本胸腺研究会, Invited

  
• 胸腺退縮に伴うＴ細胞の加齢変化とその意義

  濵﨑 洋子

  脳心血管抗加齢研究会 2016, 18 Dec. 2016, 脳心血管抗加齢研究会, Invited

  
• Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance

  HAMAZAKI Yoko

  Swiss-Kyoto Joint Symposium on Life Science, 13 Jun. 2016, Kyoto University, Invited

  
• Medullary thymic epithelial stem cells ensuring lifelong T-cell tolerance

  HAMAZAKI Yoko

  The Fifth Bizan Immunology Symposium at University of Tokushima (BISUT5) “Immune System Development, Deviation, and Regulation”, 03 Mar. 2016, Strategic Project for Innovative Research “IPUT”, University of Tokushima, Invited

  
• Medullary Thymic Epithelial Stem Cells Ensuring Lifelong Central T cell Tolerance

  HAMAZAKI Yoko

  Environment controlling normal and diseased hematopoietic and immune systems, 02 Mar. 2016, MEXT Research Project on Analysis and Synthesis of Multidimensional Immune Organ Network and RIKEN, Invited

  
• Identification of Medullary Thymic Epithelial Stem Cells and Their Potential for Controlling Autoimmunity

  Yoko Hamazaki

  25 Sep. 2015, CiRA, Invited

  
• 胸腺における中枢性自己寛容の成立と胸腺退縮に伴うＴ細胞の加齢変化

  濵﨑 洋子

  CREATE （Cardio-Renal Interaction and Translational Research Enhancement）2015, 31 Jul. 2015, Invited

  
• 免疫系・内分泌系細胞に発現するクローディンとその意義

  濵﨑 洋子

  日本薬学会 第135年会 シンポジウム（上皮を標的とした創薬研究の新展開）, 27 Mar. 2015, 日本薬学会, Invited

  
• 免疫老化

  濵﨑 洋子

  日本抗加齢医学会 専門医・指導士認定委員会主催講習会 レクチャー, 22 Mar. 2015, 日本抗加齢医学会, Invited

  
• 中枢性免疫寛容を担う胸腺髄質上皮細胞の発生とその維持

  濵﨑 洋子

  第３４回日本胸腺研究会 ミニシンポジウム 胸腺の形成と維持 最近の話題, 07 Feb. 2015, 日本胸腺研究会, Invited

  
• Thymic microenvironments: Basics, Progress and Future

  濵﨑 洋子

  第４３回日本免疫学会学術集会 オーバーヴュートーク, 10 Dec. 2014, 日本免疫学会, Invited

  
• Identification of medullary thymic epithelial stem cells ensuring lifelong central T-cell tolerance

  HAMAZAKI Yoko

  第４３回 日本免疫学会学術集会 国際シンポジウム, 10 Dec. 2014, 日本免疫学会, Invited

  
• Thymic Medullary Epithelial Stem Cells Ensuring Lifelong Central T-cell Tolerance

  HAMAZAKI Yoko

  The 24th Hot Spring Harbor International Symposium 「Recent Advance in Immunology and Inflammation」, 07 Nov. 2014, 九州大学 生体防御医学研究所, Invited

  
• 中枢性免疫寛容を担う胸腺上皮細胞の発生とその維持

  濵﨑 洋子

  第一回 GSK皮膚免疫カンファレンス, 19 Jul. 2014, Invited

  
• 中枢性免疫寛容を担う胸腺上皮細胞の発生とその維持

  濵﨑 洋子

  第５１回 日本消化器免疫学会総会 教育セミナー, 10 Jul. 2014, 日本消化器免疫学会, Invited

  
• Medullary thymic epithelial stem cells ensuring lifelong central T-cell tolerance

  Yoko Hamazaki

  第４２回日本免疫学会学術集会 国際シンポジウム, 11 Dec. 2013, 日本免疫学会, Invited

  
• Identification of claudin-expressing medullary thymic epithelial stem cells that maintain the functional medulla during life

  Yoko Hamazaki

  特定領域研究（免疫系自己）第４回国際シンポジウム, 17 Feb. 2012, 特定領域研究（免疫系自己）, Invited

  
• 加齢に伴い増加する新規CD4 T細胞サブセットの同定とその意義

  濱崎洋子

  日本食品免疫学会 第７回学術総会 シンポジウム, 18 Oct. 2011, 日本食品免疫学会, Invited

  
• 自己と非自己を見分ける免疫のしくみ

  濱崎洋子

  京大サロントーク, 12 Jun. 2011, 京都大学, Invited

  
• Claudin expression in the thymus and its implication in T-cell development

  Yoko Hamazaki

  23 Mar. 2011, 華中科技大学同済医学院 中華人民共和国, Invited

  
• 胸腺組織上皮細胞の発生・分化と自己免疫寛容成立機構の解明

  濱崎洋子

  京都大学優秀女性研究者賞（たちばな賞）授賞式, 03 Mar. 2011, 京都大学, Invited

  
• Claudin expression in the thymus: implications in immune function

  Yoko Hamazaki

  Annual International Workshop on mucosal Immunity for young investigators, 18 Apr. 2008, 東京大学医科学研究所 感染・免疫部門 炎症免疫学分野, Invited

  
• Claudin expression in the thymus and its implication in central T cell tolerance

  Yoko Hamazaki

  第３７回日本免疫学会学術集会 国際シンポジウム, 22 Nov. 2007, 日本免疫学会, Invited

  
• クローディンを通して観た胸腺髄質形成とAire陽性胸腺上皮細胞の起源

  濱崎洋子

  東京免疫フォーラム, 15 Mar. 2007, Annual International Workshop on mucosal Immunity for young investigators, Invited

  
• タイトジャンクションに局在する2つの類似したPDZドメイン含有分子MUPP1とPatjの解析

  ADACHI MAKOTO; HAMAZAKI YOKO; KOBAYASHI YUKA; TSUKITA SACHIKO; FURUSE MIKIO; TSUKITA SHOICHIRO

  生化学, 2007

  
• 胸腺組織におけるクローディンの発現とＴ細胞分化

  濱崎洋子

  免疫監視機構の基盤とその制御 公開シンポジウム, 16 Feb. 2006, 文部科学省特定領域研究 免疫監視の基盤とその維持・制御, Invited

  
• Tight Junction components in the thymus and their implications in thymic architecture and function.

  第１回RCAIワークショップ 免疫系の組織構築と免疫反応の時空間的制御機構, 18 Feb. 2005, 理化学研究所 免疫アレルギー科学 総合研究センター, Invited

  
• 上皮細胞の細胞間接着装置と極性

  農芸化学会中四国支部学術研究集会 若手研究者による講演会, 14 Jun. 2003, 農芸化学会, Invited

  
• 免疫の老化と再生医学

  濱崎 洋子

  東京都港区麻布赤坂歯科医師会・CiRA共催シンポジウム再生医学が未来を拓く ～歯の細胞とiPS細胞の可能性～, 17 Mar. 2022, Invited

  
• 免疫の老化：メカニズムの理解と健康長寿へのチャレンジ

  濱崎 洋子

  第８回京都大学―稲盛財団合同 京都賞シンポジウム 免疫系による個体統御, 13 Feb. 2022, Invited

  
• 免疫の老化と新型コロナウイルス感染症

  濱崎 洋子

  学校法人洛南高等学校 同附属中学校 講演会, 14 Dec. 2021, Invited

  
• T細胞老化と胸腺退縮

  濱崎 洋子

  第５４回日本眼炎症学会・第６３回日本コンタクトレンズ学会総会 合同シンポジウム, 24 Jul. 2021, Invited

  
• Ｔ細胞の加齢変化と免疫老化

  濱崎 洋子

  第58回日本消化器免疫学会総会 教育講演, 03 Jul. 2021, Invited

  
• Ｔ細胞の加齢変化とその意義

  濱崎 洋子

  第73回日本細胞生物学会 シンポジウム, 29 Jun. 2021, Invited

  
• なぜ免疫は老化するのか？ その仕組みの理解と再生を目指して

  濱崎 洋子

  CiRA国際広報室メディア勉強会, 22 Apr. 2021, Invited

  

Books and Other Publications

• 胸腺退縮に伴うT細胞老化とその意義

  濱崎 洋子, 特集イムノメタボリズムとT細胞の疲弊・老化 : 免疫機能不全を克服する新たなターゲット

  羊土社 実験医学, Dec. 2020

  Find Kyoto University's collection of books :

  
• 老化による免疫リプログラミング

  濱崎 洋子, 免疫リプログラミングと細胞デザイン

  医学のあゆみ 医歯薬出版株式会社, Oct. 2020

  
• 基礎を学ぶ～ウイルスに対する免疫応答～

  濱崎 洋子, 特別企画特集 緊急“新型コロナウイルス感染症（COVID-19）対策”

  日本抗加齢医学会雑誌 アンチ・エイジング医学, Jun. 2020

  
• T細胞の老化と免疫老化

  濵﨑 洋子; 湊 長博

  領域融合レビュー, 2018, Not refereed

  
• 胸腺退縮とＴ細胞老化

  濵﨑 洋子

  アンチ・エイジング医学―日本抗加齢医学会雑誌 13(3) 020-027, Jun. 2017, Not refereed

  
• 胸腺上皮幹細胞の早期活性低下に伴う胸腺退縮と免疫老化

  濵﨑 洋子; 湊長博

  実験医学 特集「臓器老化の本質に迫るステムセルエイジング」 35(8) 1309-1315, May 2017, Not refereed

  
• 免疫老化 ―Ｔ細胞の加齢変化を中心に―

  濵﨑 洋子; 湊

  腎臓内科・泌尿器科 科学評論社 3(4) 393-401, Apr. 2016, Not refereed

  
• 中枢性自己寛容を保証する胸腺髄質上皮幹細胞と自己免疫疾患におけるその制御

  濵﨑 洋子

  羊土社 実験医学増刊 自己免疫疾患―新たな発症メカニズムと治療戦略 33(12), 134-139, Aug. 2015, Not refereed

  
• T細胞の中枢性自己寛容を保証する胸腺髄質上皮幹細胞の同定とその制御

  濵﨑 洋子, Single work

  感染・免疫・炎症 45(4) 28-35, Apr. 2015, Not refereed

  
• Ｔ細胞の中枢性自己寛容を生涯にわたり保証する胸腺髄質上皮幹細胞の同定

  瀬海美穂; 濱崎洋子; 湊長博

  ライフサイエンス新着論文レビュー 大学共同利用機関法人 情報・システム研究機構 ライフサイエンス統合データベースセンター, Jan. 2015, Not refereed

  
• 免疫生物学

  監修 笹月健彦, Joint translation

  南江堂, 2010, Not refereed

  
• エッセンシャル免疫学（第２版）

  監修 笹月健彦, Joint translation

  メディカルサイエンスインターナショナル, 2010, Not refereed

  
• 胸腺の発生 （皮質・髄質上皮細胞の起源と分化）

  濱崎洋子; 湊長

  medicalbio オーム社 5(1), 24-31, 2008, Not refereed

  
• 胸腺上皮細胞の分化とクローディン

  濱崎洋子; 湊長

  医学のあゆみ 医歯薬出版株式会社 224(10), 797-798, 2008, Not refereed

  
• 胸腺上皮細胞に発現するクローディン

  濱崎洋子; 湊長

  感染・炎症、免疫 医薬の門社 38(1), 32-40, 2008, Not refereed

  
• エッセンシャル免疫学

  監修 笹月健彦, Joint translation

  メディカルサイエンスインターナショナル, 2007, Not refereed

  
• タイトジャンクションの膜裏打ち領域と上皮細胞極性

  濱崎洋子; 古瀬幹夫

  実験医学（別冊） 羊土社, 2003, Not refereed

  
• 高齢者における新型コロナウイルス反応性T細胞の特徴と交差免疫

  濱崎 洋子

  炎症と免疫（先端医学社）, 2021

  
• 胸腺退縮と恒常性増殖を基盤としたT細胞の老化

  城憲秀; 濱崎洋子

  Geriatric Medicine（老年医学）, 2021

  

Awards

• 03 Mar. 2011

  第３回京都大学優秀女性研究者賞（たちばな賞）
• 16 Jun. 2017

  花王 芸術・科学財団, The Kao Science Award
• 09 Apr. 2012

  文部科学省, 平成24年度　文部科学大臣表彰　若手科学者賞
• 03 Mar. 2011

  京都大学, 第３回　京都大学優秀女性研究者賞（たちばな賞）
• 20 May 2010

  日本細胞生物学会, 第62回　日本細胞生物学会　若手最優秀発表賞

External funds: Kakenhi

• Understanding the mechanisms of the breakdown of self-tolerance initiated from the thymus

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  Yoko Hamazaki

  From 29 Jun. 2018, To 31 Mar. 2023, Project Closed

  胸腺;中枢性自己寛容;ハッサル小体;胸腺髄質;自己寛容;胸腺上皮細胞;自己免疫疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19442/
• Understanding the role of Hassall's body abnormalities in the breakdown of self-tolerance

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  Kyoto University

  Yoko Hamazaki

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  胸腺;自己寛容;ハッサル小体;胸腺上皮細胞;自己免疫疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02640/
• 胸腺上皮幹細胞の早期老化機構の解明とその制御

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  胸腺;胸腺上皮細胞;幹細胞;老化;胸腺上皮幹細胞;胸腺退縮;免疫老化

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05641/
• Analysis of human senescence-related T cells using cohort study

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Yoko Hamazaki

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  T細胞;細胞老化;免疫老化;コホート研究;Ｔ細胞老化;老化Ｔ細胞;ゲノムコホート研究;Ｔ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15151/
• 胸腺上皮幹細胞の活性制御機構の解明とその応用

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  胸腺;胸腺上皮細胞;胸腺上皮幹細胞;自己免疫疾患;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01154/
• 免疫老化、自己免疫疾患発症における胸腺髄質上皮細胞の変容とその意義

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  胸腺;胸腺上皮細胞;幹細胞;胸腺退縮;自己免疫疾患;中枢性自己寛容

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25111505/
• Identification of medullary thymic epithelial stem cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yoko Hamazaki

  From 01 Apr. 2012, To 31 Mar. 2016, Project Closed

  胸腺;中枢性自己寛容;胸腺上皮細胞;幹細胞;胸腺退縮;自己免疫疾患;Aire;自己寛容;胸腺上皮幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590580/
• Function of claudins in Aire-expressing medullary thymic epithelial cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoko HAMAZAKI

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  T細胞分化;胸腺;自己免疫疾患;胸腺上皮細胞;クローディン;Aire;Ｔ細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790458/
• 胸腺細胞に発現するクローディンのT細胞分化選択における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  胸腺;T細胞分化;クローディン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22021020/
• Expression and function of claudins in Aire expressing medullary thymic epithelial cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoko HAMAZAKI

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  T細胞分化;胸腺;上皮細胞;胸腺上皮細胞;クローディン;Aire;免疫学;発生分化;タイトジャンクション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790373/
• Human MHC restricted T cell generation using thymic organoid

  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

  Kyoto University

  Yoko HAMAZAKI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  T細胞分化;胸腺;上皮細胞;ヒトT細胞誘導;表皮細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200069/
• 胸腺細胞に発現するクローディンのT細胞分化選択における役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  胸腺;クローディン;T細胞分化;胸腺細胞;免疫学;発生分化;上皮細胞;タイトジャンクション;クローデイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20060011/
• 胸腺組織におけるクローディンの発現とT細胞分化

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  免疫学;発生・分化;胸線;胸腺;上皮細胞;Aire;タイトジャンクション;クローディン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18790336/
• 胸腺上皮細胞におけるタイトジャンクション構成因子の発現とその組識構築における役割

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  胸腺;上皮細胞;タイトジャンクション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16790286/
• T細胞老化が加齢関連疾患の発症と病態に果たす役割の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  T細胞老化;胸腺;恒常性増殖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02849/
• ヒト胸腺発生の理解に向けたiPS細胞と胎児組織の統合トランスクリプトーム解析

  Fund for the Promotion of Joint International Research (International Collaborative Research)

  Medium-sized Section 48:Biomedical structure and function and related fields

  Kyoto University

  濱崎 洋子

  From 08 Sep. 2023, To 31 Mar. 2026, Granted

  胸腺;iPS細胞;発生;単一細胞トランスクリプトーム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23KK0136/
• T細胞老化が加齢関連疾患の発症と病態に果たす役割の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  Kyoto University

  濱崎 洋子

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  T細胞老化;胸腺;恒常性増殖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24111/

External funds: others

• 胸腺組織の発生および退縮機構の解明と 組織再構築による免疫制御法の開発

  武田科学振興財団　報彰医学研究助成

  From 2019

  濱崎　洋子
• 中枢性自己寛容を保証する胸腺髄質上皮細胞の発生と維持に関する研究

  花王科学賞

  From 2017

  濱崎洋子
• 免疫老化を担う分子細胞学的基盤の解明

  武田科学振興財団　生命科学研究助成

  From 2016

  濱崎洋子
• 胸腺上皮細胞におけるタイトジャンクション構成因子の発現とその組織構築における役割

  藤原記念財団　少壮研究者奨励金

  From 2016

  濱崎洋子
• 胸腺退縮メカニズムの解明と免疫老化制御の試み

  公益信託林女性自然科学者研究助成基金

  From 2012

  濱崎洋子
• 胸腺細胞におけるクローディンの発現とその意義

  武田科学振興財団　医学系研究奨励（基礎）

  From 2011

  濱崎洋子
• 胸腺髄質上皮細胞による自己免疫寛容の成立機構に関する研究

  先進医薬研究振興財団　血液医学分野萌芽研究助成

  From 2007

  濱崎洋子
• 胸腺髄質上皮細胞による自己免疫寛容の成立機構に関する研究

  第36回かなえ医薬振興財団「研究助成金」

  From 2007

  濱崎洋子
• 自己免疫疾患発症におけるクローディン陽性胸腺髄質上皮細胞の役割

  清水免疫学振興財団　研究助成金

  From 2006

  濱崎洋子
• Ｔ細胞老化機構とそれに基づく個体老化機構

  AMED 老化メカニズムの解明・制御プロジェクト

  From 01 Oct. 2017, To 31 Mar. 2021

  分担
• 胸腺機能の再構成による多様な反応性を持つヒトT細胞の再生

  AMED　再生医療実現拠点ネットワークプログラム

  From 01 Jun. 2020, To 31 Mar. 2024

  代表

Education

Teaching subject(s)

• 免疫学

  医学部
• 組織学

  医学部
• 医科学研究

  医学研究科
• From Apr. 2016, To Mar. 2017

  Immunology

  Spring, 医学研究科
• From Apr. 2017, To Mar. 2018

  Immunology

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  Immunology

  Spring, 医学研究科

Participation in PhD Defense

• Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

  YI RENXING, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

  SIWAKORN PUNYAWATTHANANUKOOL, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus

  NISHIDA YURI, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells

  FLAHOU Charlotte Astrid Denise, Graduate School of Medicine, Sub-chief Examiner

  25 Sep. 2023
• Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2

  YOSHIDA SHIGEO, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification

  WAJID AMIN, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• HNRNPU Facilitates Antibody Class Switch Recombination through C-NHEJ Promotion and R-loop Suppression

  AHMED MOHAMED REFAAT MOHAMED, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Smooth muscle protein 22α‐Cre recombination in resting cardiac fibroblasts and hematopoietic precursors

  IKEDA SHINYA, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow

  ABE SHINYA, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• iPS cells from Chediak-Higashi syndrome patients recapitulate the giant granules in myeloid cells

  OH SHIGEHARU, Graduate School of Medicine, Chief Examiner

  25 Sep. 2023
• A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties

  KAMIO NAOKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

  ASAHI TAKUMA, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages

  YAKU AI, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2023
• Circadian rhythm affects the magnitude of contact hypersensitivity response in mice

  MIYAKE TOSHIYA, Graduate School of Medicine, Sub-chief Examiner

  25 Jul. 2022
• Metabolic syndrome and comorbidities in psoriasis: A community-based case-control study from the Nagahama Cohort in Japan

  ENDO YUICHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2023
• Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

  NAGAHATA YOSUKE, Graduate School of Medicine, Chief Examiner

  23 Jan. 2023
• A Phenotypic Analysis of Involucrin-Membrane-Bound Ovalbumin Mice after Adoptive Transfer of Ovalbumin-Specific CD8+ T Cells

  NAKAGAWA YUJIN, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2022
• A ROCK Inhibitor Promotes Graft Survival during Transplantation of iPS-Cell-Derived Retinal Cells

  ISHIDA MASAAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells

  ITO TAKESHI, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice

  YAMAMOTO YU, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T cell sensitivity to PD-1-dependent immunoregulation

  WANG GUANNING, Graduate School of Medicine, Chief Examiner

  24 Jan. 2022
• KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia

  IZUMI KIYOTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease

  IWAMOTO YOSHIHIRO, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Generation of hypoimmunogenic T cells from genetically engineered allogeneic iPS cells for off-the-shelf cancer immunotherapy

  BO WANG, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021

Part-time lecturer

• From 01 Apr. 2007, To 31 Mar. 2016

  免疫学Ｉ

  京都保健衛生専門学校
• From 01 Apr. 2012

  免疫学

  広島大学, 歯学部
• From 09 Apr. 2013, To 30 Sep. 2013

  分子細胞機能学特論

  広島大学, 生物生産学部

Administration

School management (title, position)

• From 01 Apr. 2023, To 30 Sep. 2024

  男女共同参画推進センター研究支援・実験補助対象者選考委員会 委員
• From 01 Apr. 2015, To 31 Mar. 2017

  環境管理専門委員会 有機廃液情報管理小委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2022

  京都大学優秀女性研究者賞（たちばな賞）選考委員会委員

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2026

  人権委員会
• From 01 Apr. 2018, To 31 Mar. 2026

  共通機器管理運営委員会
• From 01 Apr. 2018, To 31 Mar. 2026

  動物実験委員会
• From 01 Apr. 2020, To 31 Mar. 2025

  発明委員会
• From 01 Apr. 2022, To 31 Mar. 2024

  iPS細胞研究所 副所長
• From 01 Apr. 2022, To 31 Mar. 2024

  教員業績評価委員会
• From 01 Apr. 2022, To 31 Mar. 2024

  教員表彰選考委員会
• From 01 Apr. 2014, To 31 Mar. 2024

  医学部動物実験委員会
• From 01 Apr. 2020, To 31 Mar. 2022

  組換えDNA実験安全委員会
• From 02 Oct. 2017, To 31 Mar. 2022

  医学研究科・医学部共同研究講座運営委員会
• From 01 Apr. 2014, To 31 Mar. 2018

  医学部動物実験施設運営委員会

Academic, Social Contribution

Committee Memberships

• From Jun. 2014, To Present

  理事, 日本細胞生物学会
• From 2014, To Present

  理事, 日本胸腺研究会
• From Oct. 2016, To Present

  評議員, 日本免疫学会
• From Dec. 2015, To Present

  広報委員, 日本免疫学会
• From 2013, To Present

  運営委員, Kyoto T Cell Conference
• From Jun. 2016, To May 2018

  会計幹事, 日本細胞生物学会
• From 2015, To 2016

  代議員, 日本細胞生物学会
• From 2014, To 2016

  会計幹事, 日本細胞生物学会
• From Jan. 2022, To Present

  選挙管理委員会 委員長, 日本免疫学会
• From Jun. 2020, To Present

  庶務幹事, 日本細胞生物学会