Basic Information

Faculty

• Faculty of Science

Professional Memberships

• 日本分子生物学会

Academic Degree

• 26 Mar. 2004

  東京工業大学修士（理学）
• 30 Jun. 2007

  東京工業大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 東京工業大学, 生命理工学部生体機構学科, 卒業

Research History

• From 2022, To Present

  京都大学 大学院理学研究科, 教授
• From 2021, To 2022

  Nagoya University, 教授
• From 2016, To 2021

  名古屋大学 大学院理学研究科, 准教授
• From 2012, To 2016

  名古屋大学 高等研究院, 特任講師
• From 2008, To 2012

  Institute of Molecular Pathology (IMP), EMBO Longterm Fellow､ 学振海外特別研究員

ID,URL

• J-Global ID

  201301091148938799

researchmap URL

• https://researchmap.jp/7000006269

Research

Research Interests

• 染色体動態
• 染色体構造
• 一分子生物学
• SMC
• 遺伝性疾患
• 初期胚発生

Research Areas

• Life sciences, Cell biology
• Life sciences, Molecular biology

Papers

• Cohesin prevents local mixing of condensed euchromatic domains in living human cells

  Shimazoe MA; Iida S; Minami K; Higashi K; Tamura S; Kobayashi Y; Fujishiro S; Xiong L; Nakazato K; Ashwin SS; Nishiyama T; Nagata Y; Kanemaki MT; Kawaguchi A; Ohkawa Y; Schermelleh L; Toyoda A; Xie L; Kurokawa K; Ochiai H; Sasai M; Maeshima K

  Nature Genetics, 08 Sep. 2026

  
• Bridging-driven condensation by eukaryotic SMC complexes is a conserved feature of genome organization

  Jang JW, Higashi TL, Tang M, Kim C, Kinoshita Y, Myeong H, Lee J, Nishiyama T, Cho WK, Uhlmann F, Dekker C, Ryu JK

  Nucleic Acids Research, 24 Aug. 2026

  
• Single-Molecule Analyses of Human Cohesin Complex.

  Yoshimi Kinoshita; Tomoko Nishiyama

  Methods in molecular biology (Clifton, N.J.), 2026

  
• Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction

  Tsubota Y.; Shintomi K.; Kinoshita K.; Masahara-Negishi Y.; Aizawa Y.; Shima M.; Hirano T.; Nishiyama T.

  Nature Communications, 2025

  
• Sororin is an evolutionary conserved antagonist of WAPL

  Mota PI, Galova M, Schleiffer A, Nguyen TT, Kovacikova I, Saad CF, Litos G, Nishiyama T, Gregan J, Peters J-M, Schlögelhofer P

  Nature Communications, 2024

  
• 姉妹染色分体間接着因子コヒーシンの一分子動態解析

  Kinoshita Y, Nishiyama T

  生物物理, 2023

  
• A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping

  Kinoshita K, Tsubota Y, Tane S, Aizawa Y, Sakata R, Takeuchi K, Shintomi K, Nishiyama T, Hirano T

  The Journal of Cell Biology, 2022

  
• SMCタンパク質複合体による染色体高次構造制御

  Sakata R, Nishiyama T

  実験医学増刊, 2022

  
• （特集）DNAの物性から理解するゲノムモダリティ

  Nishiyama T (ed.)

  月刊細胞, 2022

  
• Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

  Tane S, Shintomi K, Tsubota Y, Yoshida MM, Nishiyama T, Hirano T

  eLife, 2022

  
• Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation

  Sakata R, Niwa K, Ugarte La Torre D, Gu C, Tahara E, Takada S, Nishiyama T

  Cell Reports, 2021

  
• DNAループを押し出す〜ゲノム高次構造形成の原動力〜

  Sakata R, Nishiyama T

  News & Hot Paper Digest 実験医学, 2020

  
• Compartments in the Ring

  Nishiyama T

  Molecular Cell, 2019

  
• コヒーシン・コンデンシンの一分子解析

  Nishiyama T

  実験医学増刊, 2018

  
• Cohesion and cohesin-dependent chromatin organization

  Nishiyama T

  Current Opinion in Cell Biology, 2018

  
• Drosophila Dalmatian combines sororin and shugoshin roles in establishment and protection of cohesion

  Yamada T, Tahara E, Kanke M, Kuwata K, Nishiyama T

  The EMBO Journal, 2017

  
• Cohesin acetylation and Wapl‐Pds5 oppositely regulate translocation of cohesin along DNA

  Kanke M, Tahara E, Huis in’t Veld PJ, Nishiyama T

  The EMBO Journal, 2016

  
• Wapl is an essential regulator of chromatin structure and chromosome segregation

  Tedeschi A, Wutz G, Huet S, Jaritz M, Wuensche A, Schirghuber E, Davidson IF, Tang W, Cisneros DA, Bhaskara V, Nishiyama T, Vaziri A, Wutz A, Ellenberg J, Peters JM

  Nature, 2013

  
• Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin

  Nishiyama T, Sykora MM, Huis In ‘t Veld PJ, Mechtler K, Peters JM

  Proceedings of the National Academy of Sciences USA, 2013

  
• Sister Chromatid Cohesion

  Peters JM, Nishiyama T

  Cold Spring Harbor Perspectives in Biology (DNA replication, eds Stephen D. Bell, Marcel Méchali, Melvin L. DePamphilis), 2012

  
• Sororin mediates sister chromatid cohesion by antagonizing Wapl

  Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K, Peters JM

  Cell, 2010

  
• Molecular mechanisms for meiotic arrest that is cancelled by fertilization in vertebrate eggs

  Nishiyama T, Ohsumi K

  蛋白質核酸酵素, 2008

  
• Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

  Nishiyama T, Ohsumi K, Kishimoto T

  Nature, 2007

  
• Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis

  Nishiyama T, Yoshizaki N, Kishimoto T, Ohsumi K

  Nature, 2007

  

Books and Other Publications

• Cytostatic arrest: post-ovulation arrest until fertilization in metazoan oocytes.

  Nishiyama T.; Tachibana K.; Kishimoto T., pp 357-384

  Oogenesis: the universal process (eds Marie-Helene Verlhac and Anne Villeneuve), Wiley-Backwell, 2010

  
• The Cell Cycle: principles of Control

  Chapter 9

  Oxford University Press, London, 2007

  

Awards

• 01 Apr. 2015

  文部科学大臣表彰 若手科学者賞

Media Coverage

• 先端人「染色体の姿 手に取るように」

  朝日新聞, Jan. 2022

  
• 細胞分裂タンパク特定

  中日新聞, Jun. 2017

  
• コヒーシンの働き解明

  中日新聞, Dec. 2016

  

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IID

  9153, Fall, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IIC

  9152, Spring, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IIB

  9151, Fall, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IIA

  9150, Spring, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IA

  9146, Spring, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control ID

  9149, Fall, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IC

  9148, Spring, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Genome Integrity and control IB

  9147, Fall, Graduate School of Science, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Special Study CourseII(Biological Sciences) 17

  8720, Year-long, Faculty of Science, 12
• From 01 Apr. 2026, To 31 Mar. 2027

  Molecular Biology I

  2702, Spring, Faculty of Science, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Chromosome Biology

  3770, Spring, Faculty of Science, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Laboratory work in Biological Science A

  3762, Spring, Faculty of Science, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IID

  9153, Fall, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control ID

  9149, Fall, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IC

  9148, Spring, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IB

  9147, Fall, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IIC

  9152, Spring, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IIB

  9151, Fall, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IIA

  9150, Spring, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Genome Integrity and control IA

  9146, Spring, Graduate School of Science, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Special Study CourseII(Biological Sciences) 17

  8720, Year-long, Faculty of Science, 12
• From 01 Apr. 2025, To 31 Mar. 2026

  Molecular Biology II

  2703, Fall, Faculty of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Molecular Biology I

  2702, Spring, Faculty of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Chromosome Biology

  3770, Spring, Faculty of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory work in Biological Science A

  3762, Spring, Faculty of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Fundamental Experiments of Cellular and Molecular Biology

  2729, Fall, Faculty of Science, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IA

  9146, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IID

  9153, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control ID

  9149, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IC

  9148, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IB

  9147, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IIC

  9152, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IIB

  9151, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Genome Integrity and control IIA

  9150, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Study CourseII(Biological Sciences) 17

  8720, Year-long, Faculty of Science, 12
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Chromosome Biology

  3770, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory work in Biological Science E

  3766, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biology II

  2703, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biology I

  2702, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IIA

  9150, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control ID

  9149, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IC

  9148, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IID

  9153, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IIC

  9152, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IIB

  9151, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IB

  9147, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Genome Integrity and control IA

  9146, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Special Study CourseII(Biological Sciences) 17

  8720, Year-long, Faculty of Science, 12
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Chromosome Biology

  3770, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory work in Biological Science E

  3766, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Biology I

  2702, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2

Participation in PhD Defense

• コヒーシン分子機能におけるサブユニット依存的なDNA結合安定性と構造ダイナミクスの制御機構の解析

  SAKATA RYOTA, Graduate School of Science, Chief Examiner

  23 Mar. 2026
• Multiscale computational studies on the mechanisms that regulate chromatin conformation

  GU CHENYANG, Graduate School of Science, Sub-chief Examiner

  25 Nov. 2025
• 溶液AFMイメージングと粗視化分子動力学シミュレーションによる酵母コンデンシンの構造モデリング

  KOIDE HIROKI, Graduate School of Science, Sub-chief Examiner

  24 Mar. 2025
• ヒストンリサイクリングの分子機構に関するシミュレーション・実験融合研究

  NAGAE FURITTSU, Graduate School of Science, Sub-chief Examiner

  24 Mar. 2025
• Application of Statistical Learning to Global-Scale Marine Microbial Ecology

  KANEKO HIROTO, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024
• Unveiling the global diversity and evolution of giant viruses through ocean metagenomics

  Lingjie Meng, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024

Administration

Faculty management (title, position)

• From 01 Apr. 2026, To 31 Mar. 2027

  理学部・教育委員会委員
• From 01 Apr. 2026, To 31 Mar. 2027

  理学部・教育委員会教務委員会委員
• From 01 Apr. 2025, To 31 Mar. 2026

  理学部・教育委員会委員
• From 01 Apr. 2025, To 31 Mar. 2026

  理学部・教育委員会　アドミッション委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学研究科SACRA国際戦略部門委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学部・教育委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学部・教育委員会　少人数担任委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  理学研究科自己点検・評価委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学部・教育委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学部・教育委員会　少人数担任委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科大学院教育教務委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科SACRA国際戦略部門委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科研究科会議構成員