Basic Information

Affiliated programs (koza)

• Graduate School of Science, 化学専攻 生体分子動態化学, 准教授
• Graduate School of Medicine, 医学専攻 腫瘍ウイルス生物学, 准教授
• Graduate School of Medicine, 医科学専攻 腫瘍ウイルス生物学, 准教授

Professional Memberships

• 日本分子生物学会
• 日本生化学会

Academic Degree

• 理学修士(大阪大学)
• 博士（理学）(大阪大学)

Academic Resume (Graduate Schools)

• 大阪大学, 大学院理学研究科生物化学専攻前期課程, 修了

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 理学部化学科, 卒業

Research History

• From Apr. 2022, To Present

  Kyoto University, 医生物学研究所, 准教授
• From Oct. 2016, To Mar. 2022

  Kyoto University, ウイルス・再生医科学研究所, 准教授
• From Aug. 2007, To Sep. 2016

  Kyoto University, Institute for Virus Research, 准教授
• From Apr. 2007, To Jul. 2007

  Kyoto University, Institute for Virus Research, 助教
• From Oct. 1996, To Mar. 2007

  Kyoto University, Institute for Virus Research, 助手
• From Apr. 1993, To Sep. 1996

  Tokyo University of Pharmacy and Life Sciences, School of Life Science, 助手
• From Apr. 1992, To Mar. 1993

  Osaka University, The Institute of Scientific and Industrial Research, 教務職員

Language of Instruction

• English

ID,URL

• J-Global ID

  200901014702626829

• External link

  https://infront-biomembrane.jp

researchmap URL

• https://researchmap.jp/read0044559

Research

Research Topics, Overview of the research

• Research Topics

  Protein translocation

• Overview of the research

  We are studying molecular mechanisms of protein translocation across the bio-membrane by structural and biochemical approaches.

Research Interests

• 生体膜
• Biomembrane

Research Areas

• Life sciences, Molecular biology
• Life sciences, Functional biochemistry
• Life sciences, Cell biology

Papers

• Translation arrest cancellation of VemP, a secretion monitor in Vibrio, is regulated by multiple cis and trans factors, including SecY.

  Yuki Ikeda; Ryoji Miyazaki; Tomoya Tsukazaki; Yoshinori Akiyama; Hiroyuki Mori

  The Journal of biological chemistry, Oct. 2024

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• 細菌の遺伝子発現制御の新展開 ビブリオ属細菌における翻訳アレストを介した遺伝子発現制御

  石井 英治; 松田 重輝; 飯田 哲也; 秋山 芳展; 森 博幸

  日本細菌学雑誌, Feb. 2023

  
• 細菌の外膜生合成と品質管理に関わる2機能性プロテアーゼBepAの基質認識機構

  宮崎 亮次; 吉谷 亘平; 森 博幸; 秋山 芳展

  日本生化学会大会プログラム・講演要旨集, Sep. 2020

  
• 改良型部位特異的in vivo光架橋法による生細胞内での翻訳途上ポリペプチド鎖の相互作用動態解析

  宮崎 亮次; 秋山 芳展; 森 博幸

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• Inner membrane YfgM-PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation.

  Ryoji Miyazaki; Mengting Ai; Natsuko Tanaka; Takehiro Suzuki; Naoshi Dhomae; Tomoya Tsukazaki; Yoshinori Akiyama; Hiroyuki Mori

  The Journal of biological chemistry, 07 Oct. 2022

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• A Photo-Crosslinking Approach to Monitoring the Assembly of an LptD Intermediate with LptE in a Living Cell.

  Ryoji Miyazaki; Hiroyuki Mori; Yoshinori Akiyama

  Methods in molecular biology (Clifton, N.J.), 2022

  
• 生化学・分子生物学 ビブリオ属細菌における2つの蛋白質膜透過促進因子の生理的意義と使い分け機構

  石井 英治; 森 博幸

  医学のあゆみ, Jun. 2017

  
• 1P-041 Crystal structure of bacterial Sec translocon(The 46th Annual Meeting of the Biophysical Society of Japan)

  Tsukazaki Tomoya; Mori Hiroyuki; Fukai Shuya; Ishitani Ryuichiro; Perederma Anna; Vassylyev Dmitry G.; Ito Koreaki; Nureki Osamu

  Seibutsu Butsuri, 2008

  
• 1P356 Crystallization and X-ray diffraction of SecYE translocon from Thermus thermophilus with a Fab fragment(13. Membrane transport,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

  Tsukazaki Tomoya; Mori Hiroyuki; Ishitani Ryuichiro; Fukai Shuya; Perederina Anna; Vassylyev Dmitry G.; Ito Koreaki; Nureki Osamu

  Seibutsu Butsuri, 2006

  
• 1SA02 SecA-SecYEG protein translocation machinery : toward molecular understanding of its dynamic actions

  Mori H.; Nakatogawa H.; Vassylyev Dmitry; Ito K.

  Seibutsu Butsuri, 2004

  
• 2SA2-04 Structure and function of bacterial protein translocation machinery(2SA2 Research frontiers of protein transport across the membrane,The 47th Annual Meeting of the Biophysical Society of Japan)

  Mori Hiroyuki; Tsukazaki Tomoya; Echizen Yuka; Nureki Osamu; Ito Koreaki

  Seibutsu Butsuri, 2009

  
• 1P114 1YA1000 Crystal structure of SecDF, a Sec translocon-associated membrane protein(Membrane proteins,Early Research in Biophysics Award Candidate Presentations,Early Research in Biophysics Award,The 48th Annual Meeting of the Biophysical Society of Japan)

  Tsukazaki Tomoya; Mori Hiroyuki; Echizen Yuka; Ishitani Ryuichiro; Fukai Shyuya; Tanaka Takeshi; Perederina Anna; Vassylyev Dmitry G.; Kohno Toshiyuki; Ito Koreaki; Nureki Osamu

  Seibutsu Butsuri, 2010

  
• 3S2-3 Crystal structure of bacterial Sec translocon(3S2 Structural basis for membrane-mediated transport and signal conversion,The 46th Annual Meeting of the Biophysical Society of Japan)

  Tsukazaki Tomoya; Mori Hiroyuki; Fukai Shuya; Ishitani Ryuichiro; Perederina Anna; Vassylyev Dmitry G.; Ito Koreaki; Nureki Osamu

  Seibutsu Butsuri, 2008

  
• PiXie Analysis for Monitoring Dynamic Protein Interaction and Folding in a Living Cell

  MIYAZAKI Ryoji; MORI Hiroyuki; AKIYAMA Yoshinori

  Seibutsu Butsuri, 2021

  
• Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation.

  Ryoji Miyazaki; Yoshinori Akiyama; Hiroyuki Mori

  eLife, 15 Dec. 2020

  
• Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation.

  Yasushi Daimon; Shin-Ichiro Narita; Ryoji Miyazaki; Yohei Hizukuri; Hiroyuki Mori; Yoshiki Tanaka; Tomoya Tsukazaki; Yoshinori Akiyama

  Proceedings of the National Academy of Sciences of the United States of America, 10 Nov. 2020

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• A photo-cross-linking approach to monitor protein dynamics in living cells.

  Ryoji Miyazaki; Yoshinori Akiyama; Hiroyuki Mori

  Biochimica et biophysica acta. General subjects, Feb. 2020, Peer-reviewed, Last author, Corresponding author

  
• Tree of motility - A proposed history of motility systems in the tree of life.

  Makoto Miyata; Robert C Robinson; Taro Q P Uyeda; Yoshihiro Fukumori; Shun-Ichi Fukushima; Shin Haruta; Michio Homma; Kazuo Inaba; Masahiro Ito; Chikara Kaito; Kentaro Kato; Tsuyoshi Kenri; Yoshiaki Kinosita; Seiji Kojima; Tohru Minamino; Hiroyuki Mori; Shuichi Nakamura; Daisuke Nakane; Koji Nakayama; Masayoshi Nishiyama; Satoshi Shibata; Katsuya Shimabukuro; Masatada Tamakoshi; Azuma Taoka; Yosuke Tashiro; Isil Tulum; Hirofumi Wada; Ken-Ichi Wakabayashi

  Genes to cells : devoted to molecular & cellular mechanisms, Jan. 2020, Peer-reviewed

  
• Monitoring substrate enables real-time regulation of a protein localization pathway

  Koreaki Ito; Hiroyuki Mori; Shinobu Chiba

  FEMS Microbiology Letters, 01 Jun. 2018, Peer-reviewed

  
• A photo-cross-linking approach to monitor folding and assembly of newly synthesized proteins in a living cell

  Ryoji Miyazaki; Naomi Myougo; Hiroyuki Mori; Yoshinori Akiyama

  Journal of Biological Chemistry, 12 Jan. 2018, Peer-reviewed

  
• Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis

  Hiroyuki Mori; Sohei Sakashita; Jun Ito; Eiji Ishii; Yoshinori Akiyama

  Journal of Biological Chemistry, 2018, Peer-reviewed, Lead author, Corresponding author

  
• Heat shock transcription factor 32 defective in membrane transport can be suppressed by transposon insertion into the genes for a restriction enzyme subunit or a putative autotransporter in E. coli.

  Yura, T; Miyazaki, R; Fujiwara, K; Ito, K; Chiba, S; Mori, H; Akiyama, Y

  Genes & Genetic Systems, 2018, Peer-reviewed

  
• The TPR domain of BepA is required for productive interaction with substrate proteins and the β-barrel assembly machinery complex

  Yasushi Daimon; Chigusa Iwama-Masui; Yoshiki Tanaka; Takuya Shiota; Takehiro Suzuki; Ryoji Miyazaki; Hiroto Sakurada; Trevor Lithgow; Naoshi Dohmae; Hiroyuki Mori; Tomoya Tsukazaki; Shin-Ichiro Narita; Yoshinori Akiyama

  Molecular Microbiology, 01 Dec. 2017, Peer-reviewed

  
• 

  Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF

  Arata Furukawa; Kunihito Yoshikaie; Takaharu Mori; Hiroyuki Mori; Yusuke V. Morimoto; Yasunori Sugano; Shigehiro Iwaki; Tohru Minamino; Yuji Sugita; Yoshiki Tanaka; Tomoya Tsukazaki

  CELL REPORTS, May 2017, Peer-reviewed

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• BepA mediates productive transfer of substrate proteins to the β-barrel assembly machinery (BAM) complex.

  Daimon, Y; Masui, C; Tanaka, Y; Shiota, T; Suzuki, T; Miyazaki, R; Sakurada, H; Lithgow, T; Dohmae, N; Mori, H; Tsukazaki, T; Narita, S; Akiyama, Y

  Mol. Microbiol., 2017, Peer-reviewed

  
• A Novel SRP Recognition Sequence in the Homeostatic Control Region of Heat Shock Transcription Factor sigma(32)

  Ryoji Miyazaki; Takashi Yura; Takehiro Suzuki; Naoshi Dohmae; Hiroyuki Mori; Yoshinori Akiyama

  SCIENTIFIC REPORTS, Apr. 2016, Peer-reviewed

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• 新生鎖が奏でる細胞機能制御 新生鎖の翻訳停止を介したSec膜透過装置のリモデリングによる海洋性細菌の環境適応

  森 博幸; 石井 英治; 千葉 志信; 橋本 成祐; 小嶋 誠司; 本間 道夫; 伊藤 維昭; 秋山 芳展

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria

  Eiji Ishii; Shinobu Chiba; Narimasa Hashimoto; Seiji Kojima; Michio Homma; Koreaki Ito; Yoshinori Akiyama; Hiroyuki Mori; Linda L. Randall

  Proceedings of the National Academy of Sciences of the United States of America, 06 Oct. 2015, Peer-reviewed, Last author, Corresponding author

  
• Roles of the membrane-reentrant beta-hairpin-like loop of RseP protease in selective substrate cleavage

  Koichiro Akiyama; Shinya Mizuno; Yohei Hizukuri; Hiroyuki Mori; Terukazu Nogi; Yoshinori Akiyama

  ELIFE, Oct. 2015, Peer-reviewed

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• Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

  Kaoru Kumazaki; Toshiki Kishimoto; Arata Furukawa; Hiroyuki Mori; Yoshiki Tanaka; Naoshi Dohmae; Ryuichiro Ishitani; Tomoya Tsukazaki; Osamu Nureki

  SCIENTIFIC REPORTS, Dec. 2014, Peer-reviewed

  
• Structural basis of Sec-independent membrane protein insertion by YidC

  Kaoru Kumazaki; Shinobu Chiba; Mizuki Takemoto; Arata Furukawa; Ken-ichi Nishiyama; Yasunori Sugano; Takaharu Mori; Naoshi Dohmae; Kunio Hirata; Yoshiko Nakada-Nakura; Andres D. Maturana; Yoshiki Tanaka; Hiroyuki Mori; Yuji Sugita; Fumio Arisaka; Koreaki Ito; Ryuichiro Ishitani; Tomoya Tsukazaki; Osamu Nureki

  NATURE, May 2014, Peer-reviewed

  
• Conformational variation of the translocon enhancing chaperone SecDF

  K. Mio; T. Tsukazaki; H. Mori; M. Kawata; T. Moriya; Y. Sasaki; R. Ishitani; K. Ito; O. Nureki; C. Sato

  Journal of Structural and Functional Genomics, 2014, Peer-reviewed

  
• 細菌のタンパク質分泌を促進する膜タンパク質SecDFの構造と機能

  森 博幸; 塚崎智也

  化学と生物, Jan. 2013, Peer-reviewed, Invited

  
• Post-liberation cleavage of signal peptides is catalyzed by the site-2 protease (S2P) in bacteria

  Akira Saito; Yohei Hizukuri; Ei-ichi Matsuo; Shinobu Chiba; Hiroyuki Mori; Osamu Nishimura; Koreaki Ito; Yoshinori Akiyama

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2011, Peer-reviewed

  
• Structure and function of a membrane component SecDF that enhances protein export

  Tomoya Tsukazaki; Hiroyuki Mori; Yuka Echizen; Ryuichiro Ishitani; Shuya Fukai; Takeshi Tanaka; Anna Perederina; Dmitry G. Vassylyev; Toshiyuki Kohno; Andres D. Maturana; Koreaki Ito; Osamu Nureki

  NATURE, Jun. 2011, Peer-reviewed

  
• Conformation Transition of Sec Machinery Inferred from Bacterial SecYE Structures

  TSUKAZAKI Tomoya; MORI Hiroyuki

  Seibutsu Butsuri, 25 Dec. 2009, Peer-reviewed

  
• [Molecular mechanisms of SecA-mediated protein translocation viewed from structural studies].

  Mori H; Tsukazaki T

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, May 2009, Peer-reviewed

  
• The Sec protein secretion system ・ pp. 3-22, in Bacterial Secreted Proteins

  Ito K; Mori H

  Ed. K. Wooldridge, Caister Academic Press, Norfolk, UK, 2009, 2009, Peer-reviewed

  
• 立体構造解析からみえてきたSecA による蛋白質膜透過の分子メカニズム

  森 博幸; 塚崎智也

  蛋白質核酸酵素第54 巻pp685-695 2009, 2009, Peer-reviewed

  
• Conformational transition of Sec machinery inferred from bacterial SecYE structures

  Tomoya Tsukazaki; Hiroyuki Mori; Shuya Fukai; Ryuichiro Ishitani; Takaharu Mori; Naoshi Dohmae; Anna Perederina; Yuji Sugita; Dmitry G. Vassylyev; Koreaki Ito; Osamu Nureki

  NATURE, Oct. 2008, Peer-reviewed

  
• Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer

  Dmitry G. Vassylyev; Hiroyuki Mori; Marina N. Vassylyeva; Tomoya Tsukazaki; Yoshiaki Kimura; Tahir H. Tahirov; Koreaki Ito

  JOURNAL OF MOLECULAR BIOLOGY, Dec. 2006, Peer-reviewed

  
• The long alpha-helix of SecA is important for the ATPase coupling of translocation

  Hiroyuki Mori; Koreaki Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2006, Peer-reviewed

  
• Different modes of SecY-SecA interactions revealed by site-directed in vivo photo-cross-linking

  Hiroyuki Mori; Koreaki Ito

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2006, Peer-reviewed

  
• Cloning, expression, purification, crystallization and initial crystallographic analysis of the preprotein translocation ATPase SecA from Thermus thermophilus

  Marina N. Vassylyeva; Hiroyuki Mori; Tomoya Tsukazaki; Shigeyuki Yokoyama; Tahir H. Tahirov; Koreaki Ito; Dmitry G. Vassylyev

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Sep. 2006, Peer-reviewed

  
• Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus

  T Tsukazaki; H Mori; S Fukai; T Numata; A Perederina; H Adachi; H Matsumura; K Takano; S Murakami; T Inoue; Y Mori; T Sasaki; DG Vassylyev; O Nureki; K Ito

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Apr. 2006, Peer-reviewed

  
• せなかあわせより、向かい合わせの方が好都合? トランスロコンのアセンブリー様式

  森博幸

  蛋白質核酸酵素51,169-170, 2006, Peer-reviewed

  
• SecM facilitates translocase function of SecA by localizing its biosynthesis

  H Nakatogawa; A Murakanti; H Mori; K Ito

  GENES & DEVELOPMENT, Feb. 2005, Peer-reviewed

  
• Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase

  H Mori; N Shimokawa; Y Satoh; K Ito

  JOURNAL OF BACTERIOLOGY, Jun. 2004, Peer-reviewed

  
• Molecular architecture of protein translocase

  H. Mori

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2004, Peer-reviewed

  
• Cold shock induction of RNase R and its role in the maturation of the quality control mediator SsrA/tmRNA

  F Cairrao; A Cruz; H Mori; CM Arraiano

  MOLECULAR MICROBIOLOGY, Nov. 2003, Peer-reviewed

  
• Nearest neighbor analysis of the SecYEG complex. 2. Identification of a SecY-SecE cytosolic interface

  Y Satoh; H Mori; K Ito

  BIOCHEMISTRY, Jun. 2003, Peer-reviewed

  
• Nearest neighbor analysis of the SecYEG complex. 1. Identification of a SecY-SecG interface

  Y Satoh; G Matsumoto; H Mori; K Ito

  BIOCHEMISTRY, Jun. 2003, Peer-reviewed

  
• Importance of transmembrane segments in Escherichia coli SecY

  N Shimokawa; H Mori; K Ito

  MOLECULAR GENETICS AND GENOMICS, May 2003, Peer-reviewed

  
• Fluorescence resonance energy transfer analysis of protein translocase - SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes

  H Mori; T Tsukazaki; R Masui; S Kuramitsu; S Yokoyama; AE Johnson; Y Kimura; Y Akiyama; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003, Peer-reviewed

  
• Interfering mutations provide in vivo evidence that Escherichia coli SecE functions in multimeric states

  E Matsuo; H Mori; K Ito

  MOLECULAR GENETICS AND GENOMICS, Mar. 2003, Peer-reviewed

  
• A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects

  H Mori; Y Akiyama; K Ito

  JOURNAL OF BACTERIOLOGY, Feb. 2003, Peer-reviewed

  
• Biochemical characterization of a mutationallv altered protein translocase: Proton motive force stimulation of the initiation phase of translocation

  H Mori; K Ito

  JOURNAL OF BACTERIOLOGY, Jan. 2003, Peer-reviewed

  
• Superactive SecY variants that fulfill the essential translocation function with a reduced cellular quantity

  H Mori; Y Shimizu; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed

  
• Roles of the C-terminal end of SecY in protein translocation and viability of Escherichia coli

  K Chiba; H Mori; K Ito

  JOURNAL OF BACTERIOLOGY, Apr. 2002, Peer-reviewed

  
• The Sec protein-translocation pathway

  Hiroyuki Mori; Koreaki Ito

  Trends in Microbiology, 01 Oct. 2001, Peer-reviewed

  
• An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY

  H. Mori; K. Ito

  Proceedings of the National Academy of Sciences of the United States of America, 24 Apr. 2001, Peer-reviewed

  
• Genetic dissection of SecA: suppressor mutations against the secY205 translocase defect

  G Matsumoto; H Nakatogawa; H Mori; K Ito

  GENES TO CELLS, Dec. 2000, Peer-reviewed

  
• Two independent mechanisms down-regulate the intrinsic SecA ATPase activity

  H Nakatogawa; H Mori; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2000, Peer-reviewed

  
• Length recognition at the N-terminal tail for the initiation of FtsH-mediated proteolysis

  S Chiba; Y Akiyama; H Mori; E Matsuo; K Ito

  EMBO REPORTS, Jul. 2000, Peer-reviewed

  
• Characterization of a mutant form of SecA that alleviates a SecY defect at low temperature and shows a synthetic defect with SecY alteration at high temperature

  H Nakatogawa; H Mori; G Matsumoto; K Ito

  JOURNAL OF BIOCHEMISTRY, Jun. 2000, Peer-reviewed

  
• A mutation in secY that causes enhanced SecA insertion and impaired late functions in protein translocation

  G Matsumoto; T Homma; H Mori; K Ito

  JOURNAL OF BACTERIOLOGY, Jun. 2000, Peer-reviewed

  
• Roles of SecG in ATP- and SecA-dependent protein translocation

  G Matsumoto; H Mori; K Ito

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 1998, Peer-reviewed

  
• Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation

  Y Akiyama; A Kihara; H Mori; T Ogura; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1998, Peer-reviewed

  
• Syd, a SecY-interacting protein, excludes SecA from, the SecYE complex with an altered secY24 subunit

  E Matsuo; H Mori; T Shimoike; K Ito

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1998, Peer-reviewed

  
• Amino-terminal region of SecA is involved in the function of SecG for protein translocation into Escherichia coli membrane vesicles

  H Mori; H Sugiyama; M Yamanaka; K Sato; M Tagaya; S Mizushima

  JOURNAL OF BIOCHEMISTRY, Jul. 1998, Peer-reviewed

  
• In vitro analysis of the stop-transfer process during translocation across the cytoplasmic membrane of Escherichia coli

  K Sato; H Mori; M Yoshida; M Tagaya; S Mizushima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1997, Peer-reviewed

  
• The hydrophobic region of signal peptides is involved in the interaction with membrane-bound SecA

  H Mori; M Araki; C Hikita; M Tagaya; S Mizushima

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, May 1997, Peer-reviewed

  
• Short hydrophobic segments in the mature domain of ProOmpA determine its stepwise movement during translocation across the cytoplasmic membrane of Escherichia coli

  K Sato; H Mori; M Yoshida; M Tagaya; S Mizushima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1997, Peer-reviewed

  
• Characterization of a potential catalytic residue, Asp-133, in the high affinity ATP-binding site of Escherichia coli SecA, translocation ATPase

  K Sato; H Mori; M Yoshida; S Mizushima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1996, Peer-reviewed

  
• Stepwise movement of preproteins in the process of translocation across the cytoplasmic membrane of Escherichia coli

  K Uchida; H Mori; S Mizushima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1995, Peer-reviewed

  
• ASSOCIATION OF N-ETHYLMALEIMIDE-SENSITIVE FACTOR WITH SYNAPTIC VESICLES

  RM HONG; H MORI; T FUKUI; Y MORIYAMA; M FUTAI; A YAMAMOTO; Y TASHIRO; M TAGAYA

  FEBS LETTERS, Aug. 1994, Peer-reviewed

  
• ENGINEERED PLANT PHOSPHORYLASE SHOWING EXTRAORDINARILY HIGH-AFFINITY FOR VARIOUS ALPHA-GLUCAN MOLECULES

  H MORI; K TANIZAWA; T FUKUI

  PROTEIN SCIENCE, Oct. 1993, Peer-reviewed

  
• A CHIMERIC ALPHA-GLUCAN PHOSPHORYLASE OF PLANT TYPE-L AND TYPE-H ISOZYMES - FUNCTIONAL-ROLE OF 78-RESIDUE INSERTION IN TYPE-L ISOZYME

  H MORI; K TANIZAWA; T FUKUI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1993, Peer-reviewed

  
• POTATO-TUBER TYPE-H PHOSPHORYLASE ISOZYME - MOLECULAR-CLONING, NUCLEOTIDE-SEQUENCE, AND EXPRESSION OF A FULL-LENGTH CDNA IN ESCHERICHIA-COLI

  H MORI; K TANIZAWA; T FUKUI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1991, Peer-reviewed

  
• STRUCTURAL RELATIONSHIPS IN HIGHER-PLANT ALPHA-GLUCAN PHOSPHORYLASE ISOZYMES DIFFERENTLY LOCALIZED WITHIN CELLS

  H MORI; K NAKANO; K TANIZAWA; T FUKUI

  ENZYMES DEPENDENT ON PYRIDOXAL PHOSPHATE AND OTHER CARBONYL COMPOUNDS AS COFACTORS, 1991, Peer-reviewed

  
• UDP-GLUCOSE PYROPHOSPHORYLASE FROM POTATO-TUBER - CDNA CLONING AND SEQUENCING

  T KATSUBE; Y KAZUTA; H MORI; K NAKANO; K TANIZAWA; T FUKUI

  JOURNAL OF BIOCHEMISTRY, Aug. 1990, Peer-reviewed

  
• MOLECULAR-CLONING OF CDNA-ENCODING POTATO AMYLOPLAST ALPHA-GLUCAN PHOSPHORYLASE AND THE STRUCTURE OF ITS TRANSIT PEPTIDE

  K NAKANO; H MORI; T FUKUI

  JOURNAL OF BIOCHEMISTRY, Oct. 1989, Peer-reviewed

  

Misc.

• Respiratory chain coupling with DsbB, a membrane protein that oxidizes DsbA, the disulfide bond formation factor

  KOBAYASHI Taeko; TAKAHASHI Yuki; MORI Hiroyuki; ITO Koreaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• The formation of the SecY-SecE translocation channel as analyzed using in vitro reconstitution system and mutant SecY proteins.

  MATSUO Ei-ichi; MORI Hiroyuki; ITO Koreaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Isolation and characterization of secA mutation thar suppree cold-sensitivity of the translocation-defective seeY205 mutant.

  MATSUMOTO Gen; MORI Hiroyuki; ITO Koreaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• 次世代研究者による動的構造生命 タンパク質膜透過を駆動するモータータンパク質のスナップショット(Dynamic structural biology by next-generation researchers Snapshots of a protein translocation motor)

  Furukawa Arata; Yoshikaie Kunihito; Mori Takaharu; Mori Hiroyuki; Morimoto Yusuke; Sugano Yasunori; Iwaki Shigehiro; Minamino Tooru; Sugita Yuji; Tanaka Yoshiki; Tsukazaki Tomoya

  生物物理, Oct. 2016

  
• Promotion of mRNA degradation by the nascent polypeptide chain-dependent membrane localization in bacteria

  石井英治; 石井英治; 秋山芳展; 森博幸

  日本農芸化学会大会講演要旨集(Web), 2020

  
• 部位特異的in vivo光架橋法による大腸菌外膜タンパク質LptDの成熟過程の解析

  宮﨑亮次; 渡邊哲朗; 森 博幸; 秋山芳展

  第42回日本分子生物学会年会, Dec. 2019

  
• 細菌の翻訳途上鎖による翻訳アレストを介したmRNA分解機構の解明

  石井英治; 秋山芳展; 森 博幸

  第42回日本分子生物学会年会, Dec. 2019, Last author, Corresponding author

  
• Vibrio alginolyticusにおける新生ポリペプチド鎖依存的なmRNA分解機構

  石井英治; 秋山芳展; 森 博幸

  第53回ビブリオシンポジウム, Oct. 2019, Last author, Corresponding author

  
• 改良型部位特異的in vivo光架橋法による生細胞内での翻訳途上ポリペプチド鎖の相互作用動態解析

  宮崎 亮次; 秋山 芳展; 森 博幸

  日本生化学会大会プログラム・講演要旨集, Sep. 2019, Last author, Corresponding author

  
• 部位特異的 in vivo 光架橋法を用いた大腸菌のLPSトランスロコンサブユニットLptDの生合成過程の解析

  渡邉哲朗; 宮﨑亮次; 森 博幸; 秋山芳展

  日本農芸化学会2019年度大会, Mar. 2019

  
• ビブリオ菌の新生ポリペプチド鎖を介した発現制御におけるmRNA 二次構造の役割

  石井英治; 秋山芳展; 森 博幸

  日本農芸化学会2019年度大会, Mar. 2019, Last author

  
• 大腸菌表層ストレス応答:インプットとアウトプットに働くプロテアーゼの機能

  秋山芳展; 秋山光市郎; 岩間(舛井)千草; 大門康志; 檜作洋平; 水野慎也; 宮崎亮次; 森博幸; 禾晃和; 塩田拓也; LITHGOW Trevor; 鈴木健裕; 堂前直; 岩木薫大; 桜田洋人; SHAHRIZAL Mohammad; 田中良樹; 塚崎智也; 中山慎太郎; 成田新一郎; 上久保裕生; 林有吾

  Institute for Fermentation, Osaka. Research Communications, 2019

  
• SRP経路を介したVemPの膜透過装置への輸送と翻訳アレスト解除

  宮崎亮次; 秋山芳展; 森 博幸

  第5回ribosome meeting, Sep. 2018, Last author, Corresponding author

  
• Roles of mRNA secondary structure of vemP-secD2 intergenic region in VemP translation arrest coupled SecD2 expression

  Ishii, E; Sakashita, S; Akiyama, Y; Mori, H

  International symposium Proteins: From the Cradle to the Grave, Aug. 2018, Last author, Corresponding author

  
• Analysis of cis and trans factors involved in export and translation arrest of VemP by an in vivo photo cross-linking approach.

  Miyazaki, R; Mori, H; Akiyama Y

  International symposium Proteins: From the Cradle to the Grave, Aug. 2018, Corresponding author

  
• Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis

  Hiroyuki Mori; Sohei Sakashita; Jun Ito; Eiji Ishii; Yoshinori Akiyama

  Journal of Biological Chemistry, 2018

  
• イオン駆動型の蛋白質膜透過モーター膜蛋白質の構造解析

  古川新; 吉海江国仁; 森貴治; 森博幸; 森本雄祐; 菅野泰功; 岩木薫大; 南野徹; 杉田有治; 田中良樹; 塚崎智也

  日本蛋白質科学会年会プログラム・要旨集, 22 May 2017

  
• 大腸菌のペリプラズムプロテアーゼBepAは,TPR domainを介したタンパク質間相互作用により外膜機能を維持する

  大門康志; 舛井千草; 宮崎亮次; 櫻田洋人; 田中良樹; 鈴木健裕; 堂前直; 森博幸; 塚崎智也; 成田新一郎; 秋山芳展

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2017

  
• 構造解析から明らかにされる細菌タンパク質機能 膜輸送装置の構造と機能(Function of bacterial proteins revealed by the structural analysis Structure and function of the proton-driven protein translocation motor)

  田中 良樹; 古川 新; 森 貴治; 森 博幸; 森本 雄祐; 菅野 泰功; 岩木 薫大; 南野 徹; 杉田 有治; 塚崎 智也

  日本細菌学雑誌, Feb. 2017

  
• 二つのモーター因子によるタンパク質膜透過の駆動メカニズム

  森博幸; 石井英治

  CSJ Current Review, 2017

  
• 部位特異的in vivo光架橋法による生細胞内での新生タンパク質のフォールディング・複合体形成の動的過程の解析

  宮崎亮次; 明後尚美; 森博幸; 秋山芳展

  日本生化学会大会(Web), 2017

  
• 新生ポリペプチド鎖を介した発現制御におけるmRNA二次構造形成の重要性

  石井英治; 石井英治; 坂下宗平; 秋山芳展; 森博幸

  日本生化学会大会(Web), 2017

  
• 部位特異的in vivo光架橋法を用いた生細胞内の動的タンパク質間相互作用解析

  森博幸; 宮崎亮次; 町田裕紀子; 三登一八; 何あゆみ; 秋山光市郎; 大門康志; 舛井千草; 塚崎智也; 堂前直; 成田新一郎; 秋山芳展

  日本蛋白質科学会年会プログラム・要旨集, 19 May 2016

  
• ビブリオ属細菌VemPの翻訳アレストを介したV.SecD2発現制御におけるvemP‐V.secD2遺伝子間領域で形成される巨大な二次構造の重要性

  石井英治; 坂下宗平; 秋山芳展; 森博幸

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria (vol 112, pg E5513, 2015)

  Eiji Ishii; Shinobu Chiba; Narimasa Hashimoto; Seiji Kojima; Michio Homma; Koreaki Ito; Yoshinori Akiyama; Hiroyuki Mori

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2015

  
• 新生鎖 VemP による V.SecDF2の発現制御を利用した Vibrio 菌の 環境適応

  森 博幸

  2014 年度遺伝研研究会「単細胞の増殖メカニズムの先端的研究」三島, Mar. 2015, Invited

  
• 熱ショック転写因子σ³²とシグナル認識粒子の相互作用

  宮崎亮次; 由良隆; 鈴木健裕; 堂前直; 森博幸; 秋山芳展

  日本生化学会大会(Web), 2015

  
• ビブリオ属細菌の低食塩環境への適応:アレストペプチドVemPによるSecDF発現制御の役割

  石井英治; 千葉志信; 橋本成祐; 小嶋誠司; 本間道夫; 伊藤維昭; 秋山芳展; 森博幸

  日本生化学会大会(Web), 2015

  
• S2Pファミリー膜内切断プロテアーゼRsePの膜内挿入ループ領域を介した基質選別

  秋山光市郎; 水野慎也; 檜作洋平; 森博幸; 禾晃和; 秋山芳展

  日本生化学会大会(Web), 2015

  
• 大腸菌膜内切断プロテアーゼRsePの保存された膜内挿入ループ領域の機能解析

  AKIYAMA KOICHIRO; MIZUNO SHIN'YA; HIZUKURI YOHEI; NOGI TERUKAZU; MORI HIROYUKI; AKIYAMA YOSHINORI

  日本蛋白質科学会年会プログラム・要旨集, 26 May 2014

  
• 大腸菌膜内切断プロテアーゼRsePの保存された膜内挿入ループ領域の機能解析

  AKIYAMA KOICHIRO; MIZUNO SHIN'YA; HIZUKURI YOHEI; NOGI TERUKAZU; MORI HIROYUKI; AKIYAMA YOSHINORI

  日本蛋白質科学会年会プログラム・要旨集, 26 May 2014

  
• 部位特異的 in vivo 光架橋法によるタンパク質膜透過促進因子SecDF の基質結合部位の探索

  三登 一八; 町田 裕紀子; 塚崎 智也; 伊藤 維昭; 秋山 芳展; 森 博幸

  第１０回 ２１世紀大腸菌研究会、伊豆, Jun. 2013

  
• ビブリオ菌SecDFパラログの発現制御機構

  森 博幸

  ２０１２年度国立遺伝学研究所研究会「単細胞システムの構築とその維持機構の研究」、三島, Mar. 2013

  
• 1SDA-01 Structure and function of SecDF, a membrane integrated protein translocation enhancing factor(1SDA Prof Berg's featured lecture and dancing harmonized motility machineries,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

  Mori Hiroyuki; Mito Kazuya; Machida Yukiko; Tsukazaki Tomoya; Ito Koreaki; Akiyama Yoshinori

  Seibutsu Butsuri, 2013

  
• 大腸菌熱ショック転写因子σ³²の膜へのtargetingを介した機能制御機構

  MIYAZAKI RYOJI; YURA TAKASHI; MORI HIROYUKI; AKIYAMA YOSHINORI

  日本生化学会大会(Web), 2013

  
• ビブリオ菌のタンパク質分泌マシナリー:SecDFパラログの発現制御機構

  MORI HIROYUKI; HASHIMOTO NARIMASA; KOJIMA SEIJI; HONMA MICHIO; AKIYAMA YOSHINORI

  日本生化学会大会(Web), 2012

  
• ビブリオ菌SecDF パラログの生理機能の解明に向けて

  橋本成祐; 森博幸; 秋山芳展; 本間道夫; 小嶋誠司

  第9 回21世紀大腸菌研究会、長浜、2012年6月21日- 22日, 2012, Peer-reviewed

  
• 大腸菌熱ショック応答に関わる転写因子σ32 の膜へのtargeting を介した機能調節機構の解析

  宮崎亮次; 由良 隆; 森 博幸; 秋山芳展

  2012年度国立遺伝学研究所研 究会「代謝、増殖、分裂研究会」、三島、2 0 12 年12 月8 日-9 日, 2012, Peer-reviewed

  
• タンパク質膜透過促進因子SecDF の構造と機能

  森博幸

  2011年度国立遺伝学研究所研究会「単細胞システムの細胞構築と増殖制御の研究」、三島、2012年3月20 日-21 日, 2012, Peer-reviewed

  
• Membrane targeting of heat shock transcription factor sigma 32: An essential step for feedback control

  Takashi Yura; Bentley Lim; Carol Gross; Hiroyuki Mori; Koreaki Ito; Yoshinori Akiyama

  GENES & GENETIC SYSTEMS, Dec. 2011

  
• 熱ショック転写因子シグマ32の細胞膜移行:フィードバック制御の必須段階

  YURA TAKASHI; RIMU BENTORE; GUROSU KYARORU; MORI HIROYUKI; ITO KOREAKI; AKIYAMA YOSHINORI

  日本遺伝学会大会プログラム・予稿集, 31 Aug. 2011

  
• 蛋白質膜透過の昂進因子SecDFの構造と機能

  森博幸; 塚崎智也; 越前由香; 濡木理; 伊藤維昭

  日本蛋白質科学会年会プログラム・要旨集, 27 May 2011

  
• 蛋白質膜透過を促進する膜内在性因子SecDFの構造と機能

  森博幸; 塚崎智也; 越前友香; 秋山芳展; 濡木理; 伊藤維新昭

  生化学, 2011

  
• Structure, function and regulation of bacterial Sec machinery.

  Ito K; Tsukazaki T; Mori H; Nureki O

  International Union of Microbiological Societies 2011 Congress, Symposium "Bacterial Protein Transport", September 6-10, Sapporo, Japan 2011, 2011, Peer-reviewed

  
• バクテリアの蛋白質膜透過チャネルSecYEG と相互作用する因子の解析

  森 博幸

  理研シンポジウム「第3 回生体分子の分離・解析法の進展一膜タンパク質への応用」, 和光, 2011 年10 月28 日, 2011, Peer-reviewed

  
• タンパク質の分泌を促進するSecDF 複合体の構造と機能

  森 博幸; 塚崎智也; 越前友香; 町田裕紀子; 秋山芳展; Andres D. Maturana; 濡木 理; 伊藤維昭

  第37 回日本生体エネルギー研究会、京都、2011 年12 月20 日-22 日, 2011, Peer-reviewed

  
• Secトランスロコンと共に機能するSecDF膜蛋白質の結晶構造

  塚崎智也; 森博幸; 越前友香; 石谷隆一郎; 深井周也; PEREDERINA Anna; VASSYLYEV Dmitry G.; 田中剛史; 河野俊之; 伊藤維昭; 濡木理

  日本蛋白質科学会年会プログラム・要旨集, 2010

  
• Structure, function and evolution of bacterial protein translocation machinery.

  Mori H; Tsukazaki T; Akiyama Y; Nureki O; Ito K

  第33 回日本分子生物学会年会・第83 回日本 生化学会大会合同大会 ワークショップ「進化からみたタンパク質社会」, 神戸, 2010 年12 月7 日-10日, 2010, Peer-reviewed

  
• タンパク質膜透過促進因子SecDFの機能解析

  森博幸; 塚崎智也; 越前由香; 秋山芳展; 濡木理; 伊藤維昭

  日本生体エネルギー研究会討論会講演要旨集, 2010

  
• Sec複合体によるタンパク質膜透過機構の構造機能相関

  塚崎智也; 森博幸; 石谷隆一郎; 河野俊之; MATURANA Andres; 伊藤維昭; 濡木理

  日本生体エネルギー研究会討論会講演要旨集, 2010

  
• Structural Analysis of Bacterial Sec Translocon machinery.

  Tsukazaki T; Mori H; Ito K; Nureki O

  Gordon Research Conferences on Protein Transport Across Cell Membranes, Galveston, U.S.A, March 7-12, 2010, 2010, Peer-reviewed

  
• A functionally important intramolecular interaction in SecA: involvement of hydrophobic amino acids in motif IV and anti-parallel beta sheet in translocase activation

  Mori H; Tsukazaki T; Nureki; Ito K; Akiyama Y

  The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010, 2010, Peer-reviewed

  
• Crystal structure of SecDF, a Sec translocon-associated membrane protein.

  Tsukazaki T; Mori H; Echizen Y; Ishitani R; Fukai S; Tanaka T; Perederina A; Vassylyev D G; Kohno H; Echizen Y; Ishitani R; Fukai S; Tanaka T; Perederina A; Vassylyev D G; Kohno T; Ito K; Nureki O

  The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010, 2010, Peer-reviewed

  
• SRP-dependent targeting of sigma 32 to the membrane: A critical step for the chaperone-mediated feedback control in bacterial heat shock response.

  Yura T; Lim B; Gross C; Ito K; Mori H; Akiyama Y

  The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010, 2010, Peer-reviewed

  
• Sec トランスロコンと共に機能するSecDF 膜 タンパク質の構造

  塚崎智也; 森博幸; 越前由香; 石谷隆一郎; 深井周也; 田中剛史; Perederina A; Vassylyev D. G; 河野俊之; 伊藤維昭; 濡木理

  第10 回蛋白質科学会年会, 札幌,2010 年6 月16 日-18 日, 2010, Peer-reviewed

  
• タンパク質膜透過装置補助因子SecDF の構造と機能

  森 博幸

  遺伝研研究会「単細胞シ ステムの細胞構築と増殖機構の研究」, 三島,2010 年3 月30 日― 31日, 2010, Peer-reviewed

  
• バクテリアのタンパク質膜透過装置の構造と機能

  森博幸; 塚崎智也; 越前友香; 濡木理; 伊藤維昭

  生化学, 25 Sep. 2009

  
• 立体構造解析からみえてきたSecAによる蛋白質の膜透過の駆動機構

  森博幸; 塚崎智也

  蛋白質 核酸 酵素, 01 May 2009

  
• 部位特異的 in vivo 光架橋実験法を用いたSecG 近接因子の同定

  田中夏子; 小林元; 堂前直; 鈴木健裕; 伊藤維昭; 秋山芳展; 森博幸

  第6 回21 世紀大腸菌研究会, 静岡, 2009 年6 月11 日-12 日, 2009, Peer-reviewed

  
• Sed 莫透過装置の構造、機能および制御

  伊藤維昭; 森博幸; 塚畸智也; 濡木理

  九州大学 P&P 合同公開シンポジウム「生命活動を制御する高次複合体の構造と機能」2009 年12 月22 日-23 日、福岡, 2009, Peer-reviewed

  
• 水晶発振子上でのSec系膜タンパク質を導入した平面脂質二分子膜の構築

  森田貴之; 古澤宏幸; 塚崎智也; 森博幸; 伊藤維昭; 岡畑恵雄

  日本化学会講演予稿集, 2008

  
• 水晶発振子上での平面脂質二分子膜の構築とSec系膜タンパク質の固定化

  古澤宏幸; 森田貴之; 三友秀之; 塚崎智也; 森博幸; 伊藤維昭; 岡畑恵雄

  生化学, 2008

  
• Crystal structure of T. thermophilus Sec translocon with an Fab fragment implies a translocation-initiating state of SecY.

  Tsukazaki T; Mori H; Fukai S; Ishitani R; Mori T; Dohmae N; Perederina A; Sugita Y; Vassylyev D. G; Ito K; Nureki O

  シンポジウム 「タンパク機発現システム - シャペロンからトランスロケーターまで」 第 回日本分子生物学会年会、第 回日本生化学会大会 合同大会 神戸 2008 年12月9-12 日, 2008, Peer-reviewed

  
• SecM の分泌は低温感受性の性 をもつ

  武藤洋樹; 森博幸; 秋山芳展; 伊藤維昭

  大大学白研究所セミナー 「 白 の白 の と 抻入の分子メカニズムーその核心と 抻入の分子メカニズムーその核心にる」吹田 2008 年1 月24-25 日, 2008, Peer-reviewed

  
• 水晶発振子上での平二分子の構築とSec 系タンパクの固定化

  古沢宏幸; 森田 之; 三友秀之; 塚崎智也; 森博幸; 伊 昭; 岡畑恵

  第31 回日本分子生物学会年会、第81 回日本生化学会大会合同大会、神戸、2008 年12 月9-12 日, 2008, Peer-reviewed

  
• 細菌型Sec トランスロコン腹合体の結晶構析

  Tsukazaki, T; Mori, H; Fukai, S; Ishitani, R; Perederina, A; Vassylyev, D. G; Ito, K; Nureki

  第46 回日本生物物理学会、福岡、2008 年12 月 3-5 日, 2008, Peer-reviewed

  
• 水晶発振子上でのSec 系 タンパク を導入した平面二分子膜の構築

  森田 之; 古澤宏幸; 塚崎智也; 森博幸; 伊 昭; 岡畑恵

  日本化学会第88 春季年会、東京、2008 年3 月26-30 日, 2008, Peer-reviewed

  
• 水晶発振子上での膜タンパク質を導入した平面脂質二分子膜の構築

  三友秀之; 古澤宏幸; 塚崎智也; 森博幸; 伊藤維昭; 岡畑恵雄

  日本化学会講演予稿集, 12 Mar. 2007

  
• Protein quality control devices in the Escherichia coli plasma membrane.

  Ito K; Shimohata N; Nagamori S; Kaback H.R; Sakoh M; Chiba S; Mori H; Akiyama Y

  20th IUBMB International Congress of Biochemistry and Molecular Biology. Symposium Quality Control of Proteins and Proteolysis, Abstract p. 75, Jun 18-23,2006, 2006, Peer-reviewed

  
• 高度好熱菌由来トランスロコン関連膜タンパク質SecDF の精製・結晶化ならびにX線回折

  塚畸智也; 森博幸; 深井周也; 沼田倫征; A. Perederina; 安達宏昭; 松村浩由; 高野和文; 村上聡; 井 上豪; 森勇介; 佐々木孝友; D. Vassylyev; 濡木理; 伊藤維昭

  第6回日本蛋白質科学会年会. 要旨集P.40, 京都,2006, 2006, Peer-reviewed

  
• 水晶発振子を用いた膜タンパク質の機 能解析系の構築

  三友秀之; 古澤宏幸; 塚畸智也; 森博幸; 伊藤維昭; 岡畑恵雄

  第21 回生体機能関連部会, 題9 回バイオテクノロジー部会, 第9 回生命化学研究 会合同シンポジウム. 京大佳キャンパス,2006, 2006, Peer-reviewed

  
• Preparation of supported lipid membrane for analyses of membrane proteins on a quartz-crystal microbalance (QCM) .

  Mitomo H; Ishizu Y; Furusawa H; Tsukazaki T; Mori H; Ito K; Okahata Y

  20th IUBMB International Congress of Biochemistry and Molecular Biology. Abstract p. 337, Jun 18-23, 2006, 2006, Peer-reviewed

  
• SecY alterations that impair membrane protein folding and generate a membrane stress.

  Ito K; Nagamori S; Shimohata N; Mori H; Akiyama Y; Kaback H.R

  ASM-FEMS Conerence Protein Traffic in Prokaryotes. Abstract p. 14, May 6-10, 2006, 2006, Peer-reviewed

  
• Site-specific crosslinking studies of in vivo SecY-SecA interactions.

  Mori H; Shimokawa N; Ito K

  ASM-FEMS Conerence Protein Traffic in Prokaryotes. Abstract p. 53, May 6-10, 2006, 2006, Peer-reviewed

  
• Stress response devices in the E. coli plasma membrane and their ability to sense abnormality of integral membrane proteins.

  Ito K; Shimohata N; Mori H; Kanehara K; Akiyama Y

  IUMS 2005. XI International Congress of Bacteriology and Applied Microbiology. Symposium "Envelope Stress". Abstracts p. 214-215. July 23-28, San Francisco, California, USA, 2005, 2005, Peer-reviewed

  
• The long α-helix of SecA is important for the coupling of ATP hydrolysis \nwith protein translocation

  Mori H; Ito K

  Gordon Research Conferences "Protein transport across cell membranes". June 15-17, New Hampshre, USA, 2005, 2005, Peer-reviewed

  
• Coordinated functions of SecA-SecYEG protein translocation system.

  Ito K; Shimohata N; Nakatogawa H; Murakami A; Muto H; Akiyama Y; Tsukazaki T; Mori H

  International Symposium on Life of Proteins. Maturation, Translocation and Quality Control in the Cell. 10.30-11.3, Awajisima, Hyogo, Japan, 2005, 2005, Peer-reviewed

  
• Structural analysis of Thermus thermophilus protein translocation complexes.

  Tsukazaki T; Mori H; Peredrerina A; Vassylyev D. G; Fukai S; Nureki O; Ito K

  International Symposium on Life of Proteins. Maturation, Translocation and Quality Control in the Cell. 10.30-11.3, Awajisima, Hyogo, Japan, 2005, 2005, Peer-reviewed

  
• 膜蛋白質の形成におけるトランスロコンの機能と機能不全感知システム

  伊藤維昭; 森博幸; 下畑宣行; 秋山芳展

  第２８回日本分子生物学会年会 ワークショップ「タンパク質と脂質の オーケストレーションによる膜の形成」 要旨集 p. 112. 12.7-10, 福岡, 2005, 2005, Peer-reviewed

  
• SecM によるSecA の翻訳と機能の調節

  村上亜希子; 中戸川仁; 武藤洋樹; 森博幸; 伊藤維昭

  ２１世紀大腸菌研究会 「モデル生物大腸菌の統合的理解にむけて」 予稿集p.22. 6/23-24, 三重県志摩市, 2005, 2005, Peer-reviewed

  
• FtsHによる膜蛋白質分解開始機構 N‐terminal tailの長さの認識

  千葉志信; 秋山芳展; 森博幸; 松尾英一; 伊藤維昭

  生化学, 25 Aug. 2000

  
• 大腸菌膜結合型AAAプロテアーゼFtsHのペリプラスム領域の機能の解析

  秋山芳展; 木原章雄; 森博幸; 伊藤維昭

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• Role of periplasmic domain 1 of SecY in protein translocation.

  HONMA TAKAYUKI; MORI HIROYUKI; MATSUMOTO GEN; YOSHIHISA TOORU; NITTA SHINJI; MATSUO EIICHI; AKIYAMA YOSHINOBU; ITO KOREAKI

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1997

  

Presentations

• 分泌モニター因子VemPの翻訳アレスト解除の制御機構

  森 博幸

  2023年度国立遺伝学研究所研究会「微生物の細胞複製システムから紐解く生命のデザイン」, 29 Mar. 2024, Invited

  
• 分泌モニターVemPの翻訳停止の解除に関わる新たなcis因子の同定とその作用機序の解明に向けて

  池田優希; 矢久保俊輝; 秋山芳展; 森 博幸

  第20回21世紀大腸菌研究会, 17 Jun. 2024

  
• Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of a marine bacterium, Vibrio alginolyticus.

  MORI Hiroyuki

  Commemorative symposium for 33rd international prize for biology ‘Marine biology opens a frontier for the future’, 05 Dec. 2017, Invited

  
• Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.

  Mori, H; Sakashita, S; Ito, J; Ishii, E; Akiyama, Y

  日本生物物理学会第55回年会シンポジウム「実験と理論計算で明らかになってきた細胞環境での蛋白質間相互作用」, 19 Sep. 2017, Invited

  
• Structure and Physiological Function of SecDF That Enhances Protein Export.

  MORI Hiroyuki

  International symposium ‘Harmonized supermolecular motility machinery and its diversity’, 13 Sep. 2017, Invited

  
• Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria.

  Mori, H; Ishii, E; Chiba, S; Sakashita, S; Ito, K; Akiyama, Y

  NASCENT CHAIN BIOLOGY, 01 Sep. 2016, Invited

  
• Environmental adaptation of marine Vibrio by nascent chain-mediated remodeling of protein export machinery.

  MORI Hiroyuki

  RNA2016 satellite-symposium 'Nascent biology and ribosome function, 27 Jun. 2016, Invited

  
• Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria.

  Mori, H; Ishii, E; Chiba, S; Hashimoto, N; Kojima, S; Homma, M; Ito, K; Akiyama, Y

  BMB2015, 03 Dec. 2015, Invited

  
• タンパク質分泌を駆動する反復モーターの駆動原理.

  森 博幸

  第53回生物物理学会年会シンポジウム「生体マシナリーにおける力発生と進化の共通原理」, 14 Sep. 2015, Invited

  
• Nascent chain-mediated regulation of a SecDF paralog optimizes sodium dependence of protein export for environmental adaptation of a marine-estuarine bacterium, Vibrio alginolyticus.

  Mori, H; Ishii E; Chiba, S; Hashimoto, N; Kojima, S; Homma, M; Ito, K; Akiyama, Y

  Kyushu-U and Stanford-U Joint Research and Education Program, First Symposium: From Genes to Human Diseases, Fukuoka,, 16 Mar. 2015, Invited

  
• タンパク質膜透過促進因子SecDFの構造と機能

  森 博幸; 三登一八; 町田裕紀子; 塚崎智也; 伊藤維昭; 秋山芳展

  第51回日本生物物理学会年会シンポジウム「バーグ教授記念講演と踊る運動超分子マシナリー」、京都, 28 Oct. 2013, Invited

  
• Structure and function of SecDF, a membrane integrated protein translocation enhancing factor

  第86回日本細菌学会ワークショップ 「細胞構造研究の新展開」, 19 Mar. 2013, 日本細菌学会

  
• ビブリオ菌のタンパク質分泌マシナリー：SecDFパラログの発現制御機構

  第85回日本生化学会大会シンポジウム「運動超分子マシナリーの機能メカニズム」, 15 Dec. 2012, 日本生化学会, Invited

  
• 細菌の蛋白質膜透過装置の構造・機能・病原性との関わり.

  森 博幸

  第48回細菌学会中部支部会 (特別講演) , 名古屋, 2011年10月21日-22日, 21 Oct. 2011, Invited

  
• 蛋白質の分泌を促進する膜因子SecDFの構造と機能

  第84回日本生化学会大会シンポジウム「生体膜エネルギー変換装置の超分子科学」, 21 Sep. 2011, 日本生化学会, Invited

  
• プロトン駆動力を用いたSecDFによる蛋白質膜透過の昂進機構

  森 博幸; 塚崎智也; 越前友香; 濡木 理; 伊藤維昭

  第11回日本蛋白質科学会年会ワークショップ「細胞膜ダイナミクス：In vitro再構成系によるアプローチ」, 07 Jun. 2011, 日本蛋白質科学会, Invited

  
• 蛋白質膜透過を促進する膜内在性因子SecDF の構造と機能

  森 博幸; 塚崎智也; 越前友香; 秋山芳展; 濡木 理; 伊藤維昭

  第84 回日本生化学会大会シンポジウム「生体膜エネルギー変換装置の超分子科学」, 京都 2011 年9 月21 日-24 日, 2011

  
• Structure, function and evolution of bacterial protein translocation machinery

  Mori H; Tsukazaki T; Akiyama Y; Nureki O; Ito K

  第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会ワークショップ「進化からみたタンパク質社会」, 10 Dec. 2010, 日本分子生物学会・日本生化学会, Invited

  
• 細菌のタンパク質膜透過装置の構造と機能

  第4回細菌学若手コロッセウム, 26 Aug. 2010, 日本細菌学会, Invited

  
• バクテリアのタンパク質膜透過装置の構造と機能

  第83回日本細菌学会総会ワークショップ「細菌のタンパク質分泌系」, 27 Mar. 2010, 日本細菌学会, Invited

  
• Molecular mechanisms of SecA mediated protein translocation

  第47回日本生物物理学会年会 シンポジウム「蛋白質の膜透過輸送の最前線」, 31 Oct. 2009, 日本生物物理学会, Invited

  
• Functional dissection of bacterial Sec translocation machinery.

  Mori H; Tsukazaki T; Echizen Y; Ishitani R; Nureki O; Ito K

  International Symposium Innovative Nanoscience of Supermolecular Motor Proteins Working in Biomembranes',Kyoto, Japan, September 8-10,2009, 08 Sep. 2009, Invited

  
• Functional dissection of bacterial protein translocation machinery

  第86回日本細菌学会ワークショップ 「細胞構造研究の新展開」, 08 Sep. 2009, 特定領域研究「革新的ナノバイオ」

  
• バクテリアのタンパク質膜透過装置の 構造と機能

  森博幸; 塚崎智也; 越前友香; 濡木理; 伊藤維昭

  第82 回日本生化学会大会 シンポジウム「タンパク質膜透過装置の構造とダイナミックな機能」、神戸、2009 年10 月21 日-24 日, 2009, Invited

  
• How does SecA ATPase interact with translocon and drive protein translocation?

  Mori H

  G-COE in Chemistry " Frontier of Organelle Dynamics and Protein Functions " March 11-13, Nagoya, Japan, 2008, 12 Mar. 2008, Invited

  
• SecA ATPase はどのようにtranslocon と相互作用し、タンパク を 動しているのか

  森博幸

  「 蛋白質の膜内挿入の分子メカニズムーその核心に迫る」 阪大 蛋白質研究所セミナー 吹田 2008 年1 月24-25 日, 24 Jan. 2008, Invited

  
• Functional forms of SecA.

  Mori H

  International Symposium "Milestones in the Life of Proteins" 16 March, Kyoto 2007, 2007, Invited

  
• How does SecA ATPase drive protein translocation?

  Mori H; Ito K

  The 14th East Asia Joint Symposium on Biomedical Research, November 14, 2007 Tokyo, Japan, 2007, Invited

  
• Structure, function and regulation of the protein translocation machine of E. coli.

  Mori H; Ito K

  Discussion on Theory and Simulation of Biomolecular Nano-machines. December 12-16, Kobe, Japan,2006, 2006, Invited

  
• タンパク質膜透過装置の構造、機能、調節について

  森 博幸

  京都大学ウイルス研究所コロキウ ム「膜輸送研究の新展開」 2.14-15, 京都, 2005, 14 Feb. 2005, Invited

  
• ２つの反復モーターによるタンパク質膜透過駆動メカニズム

  森 博幸

  大阪大学蛋白質研究所セミナー第６回分子モーター研究の最前線

  

Books and Other Publications

• 「タンパク質膜透過の駆動メカニズム」分子マシンの科学

  森 博幸; 石井英治, Joint work, 第５章の執筆を担当

  化学同人, Aug. 2017, Not refereed

  
• 「ビブリオ属細菌における２つのタンパク質膜透過促進因子の生理的意義と使い分け機構」医学の歩み

  石井英治; 森 博幸, Joint work, 雑誌のい一部を担当

  医歯薬出版, 2017, Not refereed

  
• 細菌のタンパク質分泌を促進する 膜タンパク質 SecDF の構造と機能

  森 博幸; 塚崎智也

  日本農芸化学会「化学と生物」, 01 Jan. 2013, Not refereed

  
• 「立体構造解析からみえてきたSecA による蛋白質膜透過の分子メカニズム」蛋白質核酸酵素54, 685-695

  森 博幸; 塚崎智也

  共立出版, 2009, Not refereed

  
• The Sec protein secretion system

  Ito, K; Mori, H

  Caister Academic Press, Norfolk, UK., 2009, Not refereed

  

External funds: Kakenhi

• Molecular mechanisms of translation arrest-cancelation of the secretion monitor VemP

  Grant-in-Aid for Scientific Research (C)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  Hiroyuki Mori

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  VemP;翻訳停止;SecD/F;タンパパク質膜透過;分泌;PpiD;SRP;YfgM;in vivo光架橋;分泌タンパク質;SecDF2;SecY;レポーター系;prlA;SecDF;Ffh;膜透過;新生鎖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K06556/
• Molecular mechanism of protein translocation stimulation by SecDF using proton motive force

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hiroyuki Mori

  From 01 Apr. 2017, To 31 Mar. 2021, Project Closed

  SecDF;プロトン駆動力;タンパク質膜透過;PMF;細菌;分泌;PpiD;in vivo光架橋実験;膜タンパク質;エネルギー変換

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07334/
• 膜タンパク質複合体の成熟化過程をin vivo活写する

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  森 博幸

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  In vivo光架橋実験;PiXie;VemP;SecDF;LptDE;pBPA;タンパク質間相互作用;in vivo光架橋法;パルスチェイス実験;新生鎖;pulse-chase;SecD/F;LtD/E;PhoA;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05879/
• 新生鎖VemPの翻訳伸長停止／解除機構の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  森 博幸

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  VemP;SecDF;タンパク質膜透過;ビブリオ菌;翻訳伸長停止;翻訳停止;発現制御;アレストモチーフ;蛋白質;細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05666/
• Mechanism of selective substrate cleqvage and novel cellular functions ofintramembrane protease RseP

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshinori Akiyama

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  生体膜;プロテアーゼ;膜内切断;表層ストレス応答;膜タンパク質;S2P;細菌;ストレス応答;膜プロテアーゼ;大腸菌;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04350/
• A novel regulation mechanism of cellular functions by intramembrane proteolysis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshinori AKIYAMA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  大腸菌;膜プロテアーゼ;膜内タンパク質切断;表層ストレス応答;S2Pプロテアーゼ;基質探索;PDZドメイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24370054/
• Elucidation of the working principle of repetitive motors driving protein export

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Hiroyuki Mori

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  SecDF;タンパク質膜透過;プロトン駆動力;SecA ATPase;大腸菌;ビブリオ菌;細菌;モータータンパク質;膜透過;SecA;トランスロコン;PMF;SecYEG;分泌;YidC;タンパク質分泌;反復モータ;イオンチャネル;エネルギー変換

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24117003/
• Generalization of harmonized supramolecular motility machinery and its diversity

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka City University

  Makoto MIYATA

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  クライオ電子顕微鏡;急速凍結レプリカ法;技術開発・支援;スマートフォンアプリ;ビデオライブラリー;質量分析;高速AFM;3Dプリンター;電子線クライオトモグラフィー;電子顕微鏡;分子モーター;ナノバイオ;蛋白質;微生物;３Dプリンター;電子線クライオトモグラフフィー

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-24117001/
• Degradation mechanisms of sigma 32 by membrane targeting via SRP pathway

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroyuki MORI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  生体膜;σ32;SRP;Ffh;SecY;FtsH;熱ショック応答;分子シャペロン;シグマ３２

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23657128/
• SecDF function and roles of the proton motive force in protein translocation

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroyuki MORI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  生体膜;SecDF;膜透過;in vivo光架橋実験;イオントランスポーター;SecYEG;細菌;プロトン駆動力;SecA;タンパク質膜透過;SecA ATPase;結晶構造解析;カチオントランスポーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370070/
• 部位特異的in vivo光架橋実験によるSecトランスロコンの網羅的相互作用解析

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  森 博幸

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  SecYEG;SecA ATPase;SecDF;in vivo光架橋;YfgM;translocon;in vivo光架橋実験;SecG;トランスロコン;タンパク質膜透過;SecA ATPse;pベンゾフェニルアラニン;アンバーサプレッション;アジ化ナトリウム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21657049/
• SecAに依存したタンパク質膜透過反応機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  森 博幸

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  SecYEG;SecA ATPase;タンパク質膜透過;トランスロコン;結晶構造解析;SecA;ATPase

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21023015/
• Analysis of the membrane stress response in E. coli

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshinori AKIYAMA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  生体膜;膜タンパク質;表層ストレス応答;タンパク質分解;RIP;プロテアーゼ;RseP;PDZドメイン;シグマE;品質管理;分子シャペロン;シグナルペプチ;枯草菌;大腸菌;分解;シャペロン;SecY;膜組み込み

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370078/
• Nascent chain biology

  Grant-in-Aid for Scientific Research (A)

  Kyoto Sangyo University;Kyoto University

  Koreaki ITO

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  翻訳;翻訳制御;リボソーム;翻訳伸長停止配列;アレストペプチド;SecM;MifM;ナッセントーム;polypeptidyl-tRNA;シャペロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20247020/
• In vivo光架橋実験によるタンパク質膜透過装置の相互作用ネットワーク解析

  Grant-in-Aid for Exploratory Research

  Kyoto University

  森 博幸

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  in vivo光架橋;SecA;タンパク質膜透過;SecY;SecG;translocon;pBPA;アミノ酸アナログ;SecYEG;SecDF;Protein translocation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19657061/
• Structural analysis of SecA-SecYE complex from Thermus thermophilus

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroyuki MORI

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  生体膜;SecA;SecYEG;トランスロコン;タンパク質膜透過膜;ATPase;X線結晶構造解析;バクテリア;化学架橋;SecYE;Fabフラグメント;タンパク質膜透過;膜タンパク質;膜タンパク質複合体;モノクローナル抗体;タンパク質膜透過装置;Translocon;SecY;E;好熱菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19370085/
• Maintenance of the endoplasmic reticulum function by the unfolded protein response (UPR)

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Kazutoshi MORI

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  小胞体;高次構造形成;分子シャペロン;タンパク質分解;品質管理;転写誘導;翻訳抑制;遺伝子ノックアウト;メダカ;初期発生;脊索;ニワトリ細胞;オルガネラ;スプライシング;翻訳;転写;脂質;プロテアソーム;分解;フォールディング;転写透導;オルガネラ形成;生体膜;リン脂質;B細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19058009/
• Quality control of E. coli membrane proteins

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Yoshinori AKIYAMA

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  膜タンパク質;品質管理;膜プロテアーゼ;ストレス応答;タンパク質膜透過;膜内切断プロテアーゼ;ロンボイド;基質特異性;大腸菌;RIP;表層ストレス応答;SecDF;プロトン駆動力;purotea-ze

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19058007/
• タンパク質膜透過システムの一分子計測

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  森 博幸

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  一分子計測;SecA;SecYEG;translocon;タンパク質膜透過;ATPase;平面膜;再構成;SecY;E;1分子計測;前駆体タンパク質;蛍光プローブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19042014/
• Structure analysis of SecA-SecYE protein translocation machinery

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hiroyuki MORI

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  膜タンパク質;タンパク質膜透過;SecA;SecYE;高度好熱菌;結晶構造;X線;X線結晶構造解析;SecY;SecE;ATPase;チャネル, Membrane protein;Protein translocation;SecA;SecYE;Thermus thermophilus;crystal structure;X-ray

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16570094/
• 高度好熱菌SecYEタンパク質膜透過チャンネルの構造生物学的解析

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  森 博幸

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  タンパク質膜透過;SecY;SecE;SecA;X線結晶解析;蛍光共鳴エネルギー転移(FRET);クライオ電子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14780542/
• Cellular systems that control protein dynamism across the membrane

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Koreaki ITO

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  蛋白質膜透過;トランスロコン;SecY;SecA;翻訳アレスト;プロテアーゼ;ストレスレスポンス;ジスルフィド結合;膜蛋白質;トンスロコン;タンパク質膜透過;トランスコロン;蛋白質膜透渦, protein translocation across membrane;translocon;SecY;SecA;translation arrest;protease;stress response;disulfide bond

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037231/
• SecYEGチャンネルによる膜透過活性発現機構のアミノ酸残基レベルでの解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  森 博幸

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  SecY;SecG;SecA;SecE;protein translocation;channel;reconstitution;ATPase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12780535/
• Regulation mechanism of the DsbA/DsbB system that catalyzes disulfine bond formation

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Koreaki ITO

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  ジスルフィド結合;呼吸鎖;レドックス制御;ペリプラズム;大腸菌;Protein folding;タンパク質フォールディング;キノン;膜タンパク質;DsbA;DsbB, disulfide bond;Respiratory chain;Redox regulation;Periplasm;E.coli;protein folding

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12480188/
• 分泌型タンパク質の膜透過効率を制御する新たな細胞因子

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  森 博幸

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  SecY;SecA;SecE;膜透過;ATP;PMF;再構成;サプレッサー;タンパク質膜透過;ATPase;SecG

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10780441/
• Factors involved in the stop transfer process in membrane protein biogenesis

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Yoshinori AKIYAMA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  FisH;ストップトランスファー;膜タンパク質;FtsH;SecY;prlA, FtsH;stop tranfer;membrane proteins

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680691/
• SecY functions that support the dynamic movement of SecA, a protein-translocating ATPase

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Koreaki ITO

  From 01 Apr. 1997, To 31 Mar. 2000, Project Closed

  蛋白質膜透過;SecY;SecA;膜蛋白質;蛋白質相互作用;ATPase, protein translocation;SecY;SecA;membrane protein;protein-protein interaction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09480150/
• 分泌型タンパク質の膜内移動の分子機構

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Tokyo University of Pharmacy and Life Science

  森 博幸

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  膜透過;SecY;SecA;SecG

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08780685/
• 膜透過反応における分泌型タンパク質とSecAとの相互作用の分子機構

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Tokyo University of Pharmacy and Life Science

  森 博幸

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  膜透過;SecA;分泌型タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07780633/
• Molecular mechanism of protein translocation in Escherichia coli

  Grant-in-Aid for Scientific Research (A)

  Tokyo University of Pharmacy and Life Science

  Katsuko SHISHIDO

  From 01 Apr. 1995, To 31 Mar. 1998, Project Closed

  膜透過;分泌型蛋白質;大腸菌;シグナル配列;膜蛋白質;小胞体;Stepwise Translocation;SecA;前駆体タンパク質;結晶解析;シグナル認識粒子, translocation;secretory protein;Escherichia coli;signal sequence

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07408015/
• 分子シャペロンとしてのSecAの機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo University of Pharmacy and Life Science

  森 博幸

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  膜透過;SecA;分泌型タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07253225/
• 分泌型蛋白質の膜内移動の分子機構

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Tokyo University of Pharmacy and Life Science

  森 博幸

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  シグナルペプチド;SecA;分泌型蛋白質;膜透過

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06780588/
• 大腸菌BepAによる外膜タンパク質トリアージ機構とその制御

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  秋山 芳展

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  大腸菌外膜;膜タンパク質分解;タンパク質構造;タンパク質機能制御;タンパク質品質管理;外膜タンパク質;表層プロテアーゼ;トリアージ;分子シャペロン;大腸菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02571/
• タンパク質膜透過装置による分泌モニター因子VemPの翻訳アレスト解除の調節メカニズム

  Grant-in-Aid for Scientific Research (C)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  森 博幸

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  VemP;SecD/F;PpiD/YfgM;タンパク質膜透過;SecY;PMF;翻訳アレスト;PpiD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05694/
• Mechanism and regulation of the outer membrane protein triage by E. coli BepA

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  秋山 芳展

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  大腸菌外膜;膜タンパク質分解;タンパク質構造;タンパク質機能制御;タンパク質品質管理;外膜タンパク質;表層プロテアーゼ;トリアージ;分子シャペロン;大腸菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23835/

External funds: others

• Physiological functions of SecD/F paralogs

  上原記念生命科学財団研究助成金

  From 01 Apr. 2011, To 31 Mar. 2012

  森 博幸
• Molecular mechanisms of SecDF mediated protein export stimulation

  野田産業科学研究所研究助成

  From 01 Apr. 2012, To 31 Mar. 2013

  森 博幸

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Biochemistry IIB

  7093, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Biochemistry IIA

  7092, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Biochemistry IIC

  7094, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biochemistry IIB

  7197, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biochemistry IIA

  7196, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Biochemistry IID

  7095, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biochemistry IID

  7199, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biochemistry IIC

  7198, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Exercises in Biochemistry

  3628, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemistry III

  8602, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Dynamic aspects of proteins in the cell

  7033, Fall, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry IIB

  7093, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry IIA

  7092, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biochemistry IIA

  7196, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry IID

  7095, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry IIC

  7094, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biochemistry IID

  7199, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biochemistry IIC

  7198, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biochemistry IIB

  7197, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Gene Expression

  9008, Fall, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemistry III

  8602, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Exercises in Biochemistry

  3628, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Genetics I

  2704, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Biochemistry IIB

  7197, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Gene Expression

  9008, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Biochemistry IIA

  7092, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Exercises in Biochemistry

  3628, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Biochemistry IIB

  7093, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Biochemistry IID

  7199, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Biochemistry IIC

  7198, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Biochemistry IIA

  7196, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Biochemistry IIC

  7094, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Dynamic aspects of proteins in the cell

  7033, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Biochemistry IID

  7095, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Genetics I

  2704, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Biochemistry III

  8602, Fall, Faculty of Science, 2
• From Apr. 2011, To Mar. 2012

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  生物化学III

  Fall, 理学部
• From Apr. 2011, To Mar. 2012

  生物化学演習

  Fall, 理学部
• From Apr. 2012, To Mar. 2013

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Biochemistry III

  Fall, 理学部
• From Apr. 2012, To Mar. 2013

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2013, To Mar. 2014

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2013, To Mar. 2014

  Biochemistry III

  Fall, 理学部
• From Apr. 2013, To Mar. 2014

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2014, To Mar. 2015

  Biochemistry III

  Fall, 理学部
• From Apr. 2014, To Mar. 2015

  Dynamic aspects of proteins in the cell

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Biochemistry III

  Fall, 理学部
• From Apr. 2015, To Mar. 2016

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Dynamic aspects of proteins in the cell

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Biochemistry III

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Biochemistry III

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Dynamic aspects of proteins in the cell

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Biochemistry III

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Biochemistry III

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :The Frontiers in Life Science (Medical and Biological Science) Research

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Molecular Genetics I

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Introduction to Gene Expression

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Dynamic aspects of proteins in the cell

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Biochemistry III

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Exercises in Biochemistry

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :The Frontiers in Life Science (Medical and Biological Science) Research

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Molecular Genetics I

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Introduction to Gene Expression

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Biochemistry III

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Seminar on Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Biochemistry IID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Biochemistry IIA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Biochemistry IIB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Biochemistry IIC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Biochemistry IID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Exercises in Biochemistry

  Fall, 理学部

Administration

School management (title, position)

• From 01 Apr. 2011, To 31 Mar. 2013

  化学物質専門委員会　委員

Faculty management (title, position)

• From 01 Apr. 2024

  医生物学研究所　研究支援室　共同利用機器ユニット
• From 20 Jul. 2023

  学術委員会　委員
• From 01 Jul. 2021

  感染症モデル研究センター運営委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  化学物質管理委員会　委員長
• From 01 Apr. 2010, To 31 Mar. 2012

  自己点検・評価委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  動物実験委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  霊長類小委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  安全衛生委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2018

  動物実験委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2019

  共同利用機器等委員会
• From 01 Oct. 2016, To 30 Jun. 2021

  ウイルス動物実験専門委員会　委員
• From 01 Apr. 2016, To 31 Mar. 2018

  （旧ウイルス研）共同利用機器等委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2021

  （旧ウイルス研）予算委員会