Morita, Daisuke(Institute for Life and Medical Sciences (LiMe)) | Activity Database on Education and Research, Kyoto University

Morita, Daisuke

Institute for Life and Medical Sciences (LiMe) Assistant Professor

Last Updated :2025/12/20

Basic Information

Affiliated programs (koza)

Graduate School of Medicine, 医学専攻免疫分子機構学, 助教

Academic Degree

修士（生命科学）(京都大学)

博士（生命科学）(京都大学)

Language of Instruction

English

ID,URL

J-Global ID
201401019589926391

researchmap URL

https://researchmap.jp/7000009412

Last Updated :2025/12/20

Research

Research Topics, Overview of the research

Research Topics
A new aspect of immune responses directed against lipid antigens and lipopeptide antigens
Overview of the research
Acquired immunity recognizes not only peptide antigens but also lipid antigens and lipopeptide antigens. I focus on researching T cell responses direct against these “non-peptide” antigens by utilizing animal models such as rhesus monkeys.

Research Areas

Life sciences, Immunology

Papers

TAP-independent induction of N-myristoylated lipopeptide-specific CTLs in transgenic mice expressing the rhesus MHC class I allomorph, Mamu-B*098
Hiromu Suzuki; Yuka Kunimatsu; Yuya Yoshioka; Minori Asa; Sho Yamasaki; Masahiko Sugita; Daisuke Morita
The Journal of Immunology, 07 May 2025, Peer-reviewed, Last author, Corresponding author

T Cell activation and responses(human and Vitro)(Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides)
Asa Minori; Morita Daisuke; Sugita Masahiko
日本免疫学会総会・学術集会記録, Nov. 2022

Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules.
Daisuke Morita; Minori Asa; Masahiko Sugita
International immunology, 21 Jan. 2023, Peer-reviewed

Neutrophil S100A9 supports M2 macrophage niche formation in granulomas
Tatsuaki Mizutani; Toshiaki Ano; Yuya Yoshioka; Satoshi Mizuta; Keiko Takemoto; Yuki Ouchi; Daisuke Morita; Satsuki Kitano; Hitoshi Miyachi; Tatsuaki Tsuruyama; Nagatoshi Fujiwara; Masahiko Sugita
iScience, Jan. 2023, Peer-reviewed
Access this paper :

Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding
Minori Asa; Daisuke Morita; Jin Kuroha; Tatsuaki Mizutani; Naoki Mori; Bunzo Mikami; Masahiko Sugita
Journal of Biological Chemistry, Jul. 2022, Peer-reviewed
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Crystal structure of the ternary complex of TCR, MHC class I, and lipopeptides.
Daisuke Morita; Chieri Iwashita; Tatsuaki Mizutani; Naoki Mori; Bunzo Mikami; Masahiko Sugita
International immunology, 28 Jul. 2020, Peer-reviewed

Crystal structures of lysophospholipid-bound MHC class I molecules.
Yoko Shima; Daisuke Morita; Tatsuaki Mizutani; Naoki Mori; Bunzo Mikami; Masahiko Sugita
The Journal of biological chemistry, 08 Apr. 2020, Peer-reviewed, Corresponding author

Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells.
Yukie Yamamoto; Daisuke Morita; Yoko Shima; Akihiro Midorikawa; Tatsuaki Mizutani; Juri Suzuki; Naoki Mori; Takashi Shiina; Hidetoshi Inoko; Yoshimasa Tanaka; Bunzo Mikami; Masahiko Sugita
Journal of immunology (Baltimore, Md. : 1950), 15 Jun. 2019, Peer-reviewed

Neutrophils and the S100A9 protein critically regulate granuloma formation.
Yuya Yoshioka; Tatsuaki Mizutani; Satoshi Mizuta; Ayumi Miyamoto; Satoru Murata; Toshiaki Ano; Hiroshi Ichise; Daisuke Morita; Hiroyuki Yamada; Yoshihiko Hoshino; Tatsuaki Tsuruyama; Masahiko Sugita
Blood advances, 27 Dec. 2016, Peer-reviewed
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Lipopeptides: a novel antigen repertoire presented by major histocompatibility complex class I molecules
Daisuke Morita; Masahiko Sugita
IMMUNOLOGY, Oct. 2016, Peer-reviewed

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex
Daisuke Morita; Yukie Yamamoto; Tatsuaki Mizutani; Takeshi Ishikawa; Juri Suzuki; Tatsuhiko Igarashi; Naoki Mori; Takashi Shiina; Hidetoshi Inoko; Hiroaki Fujita; Kazuhiro Iwai; Yoshimasa Tanaka; Bunzo Mikami; Masahiko Sugita
NATURE COMMUNICATIONS, Jan. 2016, Peer-reviewed
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Glycerol Monomycolate Is a Novel Ligand for the Human, but Not Mouse Macrophage Inducible C-type Lectin, Mincle
Yuki Hattori; Daisuke Morita; Nagatoshi Fujiwara; Daiki Mori; Takashi Nakamura; Hideyoshi Harashima; Sho Yamasaki; Masahiko Sugita
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2014, Peer-reviewed
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Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques
Daisuke Morita; Ayumi Miyamoto; Yuki Hattori; Takaya Komori; Takashi Nakamura; Tatsuhiko Igarashi; Hideyoshi Harashima; Masahiko Sugita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, Peer-reviewed

Major T Cell Response to a Mycolyl Glycolipid Is Mediated by CD1c Molecules in Rhesus Macaques
Daisuke Morita; Yuki Hattori; Takashi Nakamura; Tatsuhiko Igarashi; Hideyoshi Harashima; Masahiko Sugita
INFECTION AND IMMUNITY, Jan. 2013, Peer-reviewed

Molecular Requirements for T Cell Recognition of N-Myristoylated Peptides Derived from the Simian Immunodeficiency Virus Nef Protein
Daisuke Morita; Yukie Yamamoto; Juri Suzuki; Naoki Mori; Tatsuhiko Igarashi; Masahiko Sugita
JOURNAL OF VIROLOGY, Jan. 2013, Peer-reviewed

Cutting Edge: T Cells Monitor N-Myristoylation of the Nef Protein in Simian Immunodeficiency Virus-Infected Monkeys
Daisuke Morita; Tatsuhiko Igarashi; Mariko Horiike; Naoki Mori; Masahiko Sugita
JOURNAL OF IMMUNOLOGY, Jul. 2011, Peer-reviewed

A Microbial Glycolipid Functions as a New Class of Target Antigen for Delayed-type Hypersensitivity
Takaya Komori; Takashi Nakamura; Isamu Matsunaga; Daisuke Morita; Yuki Hattori; Hirotaka Kuwata; Nagatoshi Fujiwara; Kenji Hiromatsu; Hideyoshi Harashima; Masahiko Sugita
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2011, Peer-reviewed
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Mycolyltransferase from Mycobacterium leprae Excludes Mycolate-containing Glycolipid Substrates
Hitomi Nakao; Isamu Matsunaga; Daisuke Morita; Takako Aboshi; Toshiyuki Harada; Yoshiaki Nakagawa; Naoki Mori; Masahiko Sugita
JOURNAL OF BIOCHEMISTRY, Nov. 2009, Peer-reviewed

Trans-species activation of human T cells by rhesus macaque CD1b molecules
Daisuke Morita; Kumiko Katoh; Toshiyuki Harada; Yoshiaki Nakagawa; Isamu Matsunaga; Tomoyuki Miura; Akio Adachi; Tatsuhiko Igarashi; Masahiko Sugita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2008, Peer-reviewed

Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, alpha-acaridial
Toshio Sasai; Yunosuke Hirano; Sayaka Maeda; Isamu Matsunaga; Atsushi Otsuka; Daisuke Morita; Ritsuo Nishida; Hideo Nakayama; Yasumasa Kuwahara; Masahiko Sugita; Naoki Mori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2008, Peer-reviewed

Genes, proteins and function of monkey group 1 CD1
D. MORITA; K. KATOH; I. MATSUNAGA; T. MIURA; T. IGARASHI; M. SUGITA
(1) Laboratory of Primate Model, IVR Biochem. Biophys. Res. Commun. 377:889, 2008, 2008, Peer-reviewed

Allergic contact dermatitis with mite-derived lidpids
N. MORI; I .MATSUNAGA; A. OTSUKA; D. MORITA; M. SUGITA
(1) Graduate School of Agriculture, Kyoto University Biiochem. Biophys. Res. Commun. 375:336, 2008, 2008, Peer-reviewed

抗酸菌脂質を標的にした新しい感染防御機構
杉田昌彦; 森田大輔
BIO Clinica 22 巻 921-925, 2007, 2007, Peer-reviewed

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2(+), a homolog of the human gene predisposing to tuberous sclerosis complex
Yukiko Nakase; Keiko Fukuda; Yuji Chikashige; Chihiro Tsutsumi; Daisuke Morita; Shinpei Kawamoto; Maxi Ohnuki; Yasushi Hiraoka; Tomohiro Matsumoto
GENETICS, Jun. 2006, Peer-reviewed

Misc.

Structure and function of lipopeptide-presenting MHC class I molecules
麻実乃莉; 森田大輔; 杉田昌彦
日本生体防御学会学術総会講演抄録集, 2022

D-12 脂質を標的としたサル免疫システムの解明
杉田昌彦; 森田大輔
霊長類研究所年報, 04 Oct. 2012
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E-3 脂質を標的としたサル免疫システムの解明
杉田昌彦; 森田大輔
霊長類研究所年報, 04 Dec. 2014
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E-3 脂質を標的としたサル免疫システムの解明
杉田昌彦; 森田大輔
霊長類研究所年報, 13 Nov. 2013
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結核肉芽腫形成を制御する好中球機能の解明
水谷龍明; 吉岡祐弥; 大内結貴; 森田大輔; 森田大輔; 杉田昌彦; 杉田昌彦
日本生化学会大会(Web), 2017

Lipopeptide Ag presentation by MHC class I molecules: evidence from SIV-infected monkeys
MORITA DAISUKE; SUGITA MASAHIKO
日本免疫学会総会・学術集会記録, 18 Nov. 2013

Lipid-specific adaptive immunity in tuberculosis and AIDS.
SUGITA Masahiko; MORITA Daisuke; IGARASHI Tatsuhiko
The 19th East Asia Joint Symposium on Biomedical Research. Seoul, Korea. August 23-24., Aug. 2012

ウイルス蛋白質のミリスチン酸修飾を検知する新たなT細胞応答
森田大輔
第23回日本生体防御学会学術集会, 11 Jul. 2012, Peer-reviewed

Nef蛋白質のミリスチン酸修飾をモニターする新たな免疫システム
森田大輔
第25回日本エイズ学会学術集会, 02 Dec. 2011, Peer-reviewed

リポペプチド: エイズ免疫の新たな標的分子
森田大輔; 堀池麻理子; 三浦智行; 森直樹; 五十嵐樹彦; 杉田昌彦
第13回京都免疫ワークショップ学術集会大阪2010 年2 月13日, 2010, Peer-reviewed

らい菌のミコール酸転移酵素によるミコール酸糖脂質の産生
松永勇; 中尾瞳; 森田大輔; 杉田昌彦
第82 回日本生化学会総会神戸平成21年10月21-24 日, 2009, Peer-reviewed

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2(+), a homolog of the human gene predisposing to tuberous sclerosis complex (vol 173, pg 569, 2006)
Y. Nakase; K. Fukuda; Y. Chikashige; C. Tsutsumi; D. Morita; S. Kawamoto; M. Ohnuki; Y. Hiraoka; T. Matsumoto
GENETICS, Aug. 2006

Presentations

脂質抗原提示タンパク質CD1aに認識されるリポペプチドDDM-838の構造活性相関研究
岡本将志; 森田大輔; 秋葉宏樹; 服部明; 有地法人; 掛谷秀昭; 大野浩章; 井貫晋輔
日本薬学会第145年会, 28 Mar. 2025

CD1a拘束性T細胞を制御する結核菌由来リポペプチドDDM-838の構造活性相関研究
岡本将志; 森田大輔; 秋葉宏樹; 服部明; 有地法人; 掛谷秀昭; 大野浩章; 井貫晋輔
第41回メディシナルケミストリーシンポジウム

Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.
Morita D; Sugita M
The 50th Annual Meeting of the Japanese Society for Immunology, 09 Dec. 2021

Lipopeptide antigen presentation mediated by classical MHC class I molecules.
Asa, M; Morita, D; Sugita, M
The 13th International CD1-MR1 Conference., 26 Feb. 2024

N-myristoylated lipopeptide-specific T cell development independently of TAP transporters.
Suzuki, H; Morita, D
The 52nd Annual Meeting of the Japanese Society for Immunology., 19 Jan. 2024

A molecular basis for specific recognition of lipopeptides by TCRs.
Morita, D; Sugita, M
The 51th Annual Meeting of the Japanese Society for Immunology, 09 Dec. 2022

T-cell recognition of the lipopeptide-bound MHC class I complex; evidence from the crystal structure
Daisuke Morita; Chieri Iwashita; Masahiko Sugita
The 15th International Symposium of the Institute Network for Biomedical Sciences 2020, 05 Nov. 2020

霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構
森田大輔
第29回日本生体防御学会学術総会, 28 Jun. 2018

霊長類研究から見えてきた、「非ペプチド」抗原を標的とする新しい免疫システムの解明
森田大輔
ForteBioセミナーin大阪 2018, 10 May 2018

Lipopeptide: a novel immune target for viral infection
Daisuke Morita
日本薬学会第138年会, 28 Mar. 2018

Discovery of N-myristoylated lipopeptide Ag-presenting MHC class I molecules
Daisuke Morita
East Asia Joint Symposium, 18 Oct. 2016

「リポペプチド免疫応答」の発見とその分子機構の解明
森田大輔
第27回日本生体防御学会学術総会, 08 Jul. 2016

Discovery of lipopeptide Ag-presenting molecules: its molecular identity and X-ray crystallographic structure
Daisuke Morita
第44回日本免疫学会学術集会, 18 Nov. 2015

Discovery of a lipopeptide Ag-presenting molecule : its molecular identity and X-ray crystallographic structure
Daisuke Morita
第10回研究所ネットワーク国際シンポジウム, 24 Jul. 2015

霊長類研究から見えてきた、新しい獲得免疫応答
森田大輔
第30回藤田カンファレンス, 08 Sep. 2013, Invited

Awards

06 Feb. 2017
公益財団法人加藤記念バイオサイエンス振興財団, 優秀賞
「リポペプチド」免疫の学術基盤構築, Publisher
森田大輔

13 Feb. 2010
京都免疫ワークショップ学術集会, 石坂公成奨励賞

08 Sep. 2013
藤田カンファレンス, 藤田カンファレンスFC奨励賞

08 Jul. 2016
Japanese Society for Host Defense Research, 平成28年度日本生体防御学会奨励賞

18 Nov. 2015
Japanese Society for Immunology, Best Presentation Award 2015

External funds: Kakenhi

Lipopeptide Immunity: A novel approach to autoimmunity
Grant-in-Aid for Scientific Research (C)
Basic Section 49070:Immunology-related
Kyoto University
Daisuke Morita
From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
MHCクラス1;HLA;リポペプチド;ミリスチン酸修飾;エイズ;自己免疫
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07078/

Novel strategy of host defense targeted for "viral lipopeptides"
Grant-in-Aid for Scientific Research (C)
Basic Section 49070:Immunology-related
Kyoto University
Daisuke Morita
From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
MHCクラス1;リポペプチド;ミリスチン酸修飾;エイズ;Nef;T細胞エピトープ;リゾリン脂質;内在性リガンド;MHC class I;抗原提示
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07172/

Identification and functional analysis of a novel class of human MHC class I molecules presenting lipopeptide antigens
Grant-in-Aid for Young Scientists (B)
Kyoto University
Daisuke Morita
From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
MHCクラス1;リポペプチド;Nef;ミリスチン酸修飾;エイズ
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19151/

Crystallographic analysis of the MHC class I:lipopeptide complex and identification of the lipopepitide-angigen presentation pathway
Grant-in-Aid for Young Scientists (B)
Kyoto University
Daisuke Morita
From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
MHCクラス1;リポペプチド;ミリスチン酸修飾;HIV;抗原提示;MHCクラス１;エイズ;ウイルス感染
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860323/

「リポペプチド」を提示するMHCクラスI分子の同定とその免疫機能解析
Grant-in-Aid for Research Activity Start-up
Kyoto University
森田大輔
From 30 Aug. 2013, To 31 Mar. 2015, Declined
MHC;ミリスチン酸修飾;リポペプチド
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25893102/

リポペプチド免疫応答を起点とした、新たな自己免疫病態の解明と制御
Grant-in-Aid for Scientific Research (C)
Basic Section 49070:Immunology-related
Kyoto University
森田大輔
From 01 Apr. 2024, To 31 Mar. 2028, Granted
MHCクラス1;HLA;リポペプチド;ミリスチン酸修飾;自己免疫;アレルギー;細胞傷害性T細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10256/

External funds: others

「リポペプチド免疫」の賦活化を基軸とした、新たなワクチン戦略の構築
公益財団法人武田科学振興財団, 2024年度武田科学振興財団医学系研究助成（感染領域）
From 20 Sep. 2024, To 31 Mar. 2029
森田大輔
研究代表者

リポペプチド提示MHCクラス1分子による自己免疫の新局面
公益財団法人小野医学研究財団, 2024年度小野医学研究財団研究奨励助成
From 24 Mar. 2025, To 31 Mar. 2026
森田大輔
研究代表者

Lipopeptide-presenting MHC class I-transgenic mice develop autoimmune disorder associated with viral infection.
京都大学医生物学研究所, LiMe Office of Director's Research Grants Program (2023)
From 01 Jul. 2023, To 31 Mar. 2024
研究代表者

脂質免疫応答に着目した自己免疫の新機序解明
一般財団法人藤原記念財団, 一般財団法人藤原記念財団少壮奨励金
From 01 Jul. 2023, To 31 Mar. 2024
研究代表者

「リポペプチド」を提示するMHCクラスI分子の同定とその免疫機能解析
京都大学, 京都大学若手研究者スタートアップ研究費
From 2013, To 2014
森田大輔
研究代表者

「リポペプチド」免疫の学術基盤構築
加藤記念バイオサイエンス振興財団, 第28回加藤記念バイオサイエンス振興財団研究助成金
From 06 Feb. 2017, To 31 Mar. 2019
森田大輔
研究代表者

リポペプチドを標的とした感染防御と自己免疫の新機序
公益財団法人上原記念生命科学財団, 公益財団法人上原記念生命科学財団2020年度研究奨励金
From 15 Feb. 2021, To 30 Apr. 2022
森田大輔
研究代表者

リポペプチド免疫を標的とした新たなウイルス制御戦略
一般財団法人清水免疫学・神経科学振興財団, 一般財団法人清水免疫学・神経科学振興財団研究助成金
From 07 Feb. 2023
森田大輔
研究代表者

リポペプチド：エイズ免疫の新たな標的分子
第28回清水免疫学振興財団助成金
From 04 Dec. 2010
森田大輔

Lipopeptide vaccine development by the use of BCG technology
京都大学ウイルス・再生医科学研究所, INFRONT Office of Directors’ Research Grants Program (2020)
From 01 Jul. 2020, To 31 Mar. 2021
森田大輔

Last Updated :2025/12/20

Education

Teaching subject(s)

From 01 Apr. 2024, To 31 Mar. 2025
ILAS Seminar
Z001, Spring, Institute for Liberal Arts and Sciences, 2

From Apr. 2014, To Mar. 2015
The Front Line of Life Science Research II
Spring, 全学共通科目

From Apr. 2015, To Mar. 2016
The Front Line of Life Science Research II
Spring, 全学共通科目

From Apr. 2019, To Mar. 2020
ILAS Seminar
Spring, 全学共通科目

Last Updated :2025/12/20

Administration

School management (title, position)

留学支援ネットワークメンバー

Faculty management (title, position)

From 01 Apr. 2024
化学物質管理委員会　委員

From 01 Apr. 2018
共同利用機器等委員会

From 01 Apr. 2013, To 31 Mar. 2017
化学物質管理委員会　委員

From 01 Apr. 2014, To 31 Mar. 2017
共同利用機器等委員会　委員

From 01 Oct. 2016, To 31 Mar. 2018
（旧ウイルス研）共同利用機器等委員会　委員

From 01 Apr. 2014, To 31 Mar. 2016
図書委員会　委員

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