Our cells is constantly under the threat of DNA damage stress. The first step of DNA damage response is efficient detection of DNA damage, Since we found that the feedback system of DNA damage detection system that promote rapid inactivation after the activation of DNA damage response. Our final aim is to understand the molecular nature of the feedback system and uncover the universal nature of the feedback regulation at the stress responses.
Research Interests
バイオイメージング
細胞周期
DDK
チェックポイント
DNA損傷
環境応答
DNA修復
Rad9
細胞内情報伝達
リン酸化
染色体
分配
DNA結合
細胞分裂
無核
Research Areas
Life sciences, Molecular biology
Environmental science/Agricultural science, Environmental effects of chemicals
Environmental science/Agricultural science, Environmental effects of radiation
Papers
E‐cadherin‐dependent coordinated epithelial rotation on a two‐dimensional discoidal pattern
Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics
Masae Ikura; Kanji Furuya; Atsuhiko Fukuto; Ryo Matsuda; Jun Adachi; Tomonari Matsuda; Akira Kakizuka; Tsuyoshi Ikura
MOLECULAR AND CELLULAR BIOLOGY, May 2016, Peer-reviewed
Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin
Masae Ikura; Kanji Furuya; Shun Matsuda; Ryo Matsuda; Hiroki Shima; Jun Adachi; Tomonari Matsuda; Takuma Shiraki; Tsuyoshi Ikura
MOLECULAR AND CELLULAR BIOLOGY, Dec. 2015, Peer-reviewed
Absolute quantification of acetylation and phosphorylation of the histone variant H2AX upon ionizing radiation reveals distinct cellular responses in two cancer cell lines
Shun Matsuda; Kanji Furuya; Masae Ikura; Tomonari Matsuda; Tsuyoshi Ikura
RADIATION AND ENVIRONMENTAL BIOPHYSICS, Nov. 2015, Peer-reviewed
論考“科学教育と科学研究”
古谷寛治
こころの未来, Jun. 2014
Synchronous activation of cell division by light or temperature stimuli in the dimorphic yeast Schizosaccharomyces japonicus
Sho Okamoto; Kanji Furuya; Shingo Nozaki; Keita Aoki; Hironori Niki
Eukaryotic Cell, Sep. 2013, Peer-reviewed
Hyphal differentiation induced via a DNA damage checkpoint-dependent pathway engaged in crosstalk with nutrient stress signaling in Schizosaccharomyces japonicus
Kanji Furuya; Hironori Niki
CURRENT GENETICS, Dec. 2012, Peer-reviewed
Construction of an insertion marker collection of Sz. japonicus (IMACS) for genetic mapping and a fosmid library covering its genome
Kanji Furuya; Keita Aoki; Hironori Niki
YEAST, Jun. 2012, Peer-reviewed
Phosphorylated Rad9 is released from damaged chromatin
Kanji Furuya
Seikagaku, 2012, Peer-reviewed
Construction of diploid zygotes by interallelic complementation of ade6 in Schizosaccharomyces japonicus
Kanji Furuya; Hironori Niki
YEAST, Oct. 2011, Peer-reviewed
Breakage of the nuclear envelope by an extending mitotic nucleus occurs during anaphase in Schizosaccharomyces japonicus
Comparative Functional Genomics of the Fission Yeasts
Nicholas Rhind; Zehua Chen; Moran Yassour; Dawn A. Thompson; Brian J. Haas; Naomi Habib; Ilan Wapinski; Sushmita Roy; Michael F. Lin; David I. Heiman; Sarah K. Young; Kanji Furuya; Yabin Guo; Alison Pidoux; Huei Mei Chen; Barbara Robbertse; Jonathan M. Goldberg; Keita Aoki; Elizabeth H. Bayne; Aaron M. Berlin; Christopher A. Desjardins; Edward Dobbs; Livio Dukaj; Lin Fan; Michael G. FitzGerald; Courtney French; Sharvari Gujja; Klavs Hansen; Dan Keifenheim; Joshua Z. Levin; Rebecca A. Mosher; Carolin A. Mueller; Jenna Pfiffner; Margaret Priest; Carsten Russ; Agata Smialowska; Peter Swoboda; Sean M. Sykes; Matthew Vaughn; Sonya Vengrova; Ryan Yoder; Qiandong Zeng; Robin Allshire; David Baulcombe; Bruce W. Birren; William Brown; Karl Ekwall; Manolis Kellis; Janet Leatherwood; Henry Levin; Hanah Margalit; Rob Martienssen; Conrad A. Nieduszynski; Joseph W. Spatafora; Nir Friedman; Jacob Z. Dalgaard; Peter Baumann; Hironori Niki; Aviv Regev; Chad Nusbaum
SCIENCE, May 2011, Peer-reviewed
Novel episomal vectors and a highly efficient transformation procedure for the fission yeast Schizosaccharomyces japonicus
Keita Aoki; Reiko Nakajima; Kanji Furuya; Hironori Niki
YEAST, Dec. 2010, Peer-reviewed
DDK Phosphorylates Checkpoint Clamp Component Rad9 and Promotes Its Release from Damaged Chromatin
Kanji Furuya; Izumi Miyabe; Yasuhiro Tsutsui; Francesca Paderi; Naoko Kakusho; Hisao Masai; Hironori Niki; Antony M. Carr
MOLECULAR CELL, Nov. 2010, Peer-reviewed
The DNA Damage Checkpoint Regulates a Transition between Yeast and Hyphal Growth in Schizosaccharomyces japonicus
Kanji Furuya; Hironori Niki
MOLECULAR AND CELLULAR BIOLOGY, Jun. 2010, Peer-reviewed
Isolation of heterothallic haploid and auxotrophic mutants of Schizosaccharomyces japonicus.
Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin
Yuu Kimata; Akihisa Matsuyama; Koji Nagao; Kanji Furuya; Chikashi Obuse; Minoru Yoshida; Mitsuhiro Yanagida
JOURNAL OF CELL SCIENCE, Apr. 2008, Peer-reviewed
Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice
Mihoko Kai; Kanji Furuya; Francesca Paderi; Antony M. Carr; Teresa S. F. Wang
NATURE CELL BIOLOGY, Jun. 2007, Peer-reviewed
Postreplication repair and PCNA modification in Schizosaccharomyces pombe
Jonathan Frampton; Anja Irmisch; Catherine M. Green; Andrea Neiss; Michelle Trickey; Helle D. Ulrich; Kanji Furuya; Felicity Z. Watts; Antony M. Carr; Alan R. Lehmann
MOLECULAR BIOLOGY OF THE CELL, Jul. 2006, Peer-reviewed
Identification and functional analysis of TopBP1 and its homologs
Garcia, V; K Furuya; AM Carr
DNA REPAIR, Nov. 2005, Peer-reviewed
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BCRT domains of Rad4(TOPBP1)
K Furuya; M Poitelea; L Guo; T Caspari; AM Carr
GENES & DEVELOPMENT, May 2004, Peer-reviewed
DNA checkpoints in fission yeast
K Furuya; AM Carr
JOURNAL OF CELL SCIENCE, Oct. 2003, Peer-reviewed
Control of localization of a spindle checkpoint protein, Mad2, in fission yeast
AE Ikui; K Furuya; M Yanagida; T Matsumoto
JOURNAL OF CELL SCIENCE, Apr. 2002, Peer-reviewed
Requirement of chromatid cohesion proteins Rad21/Scc1 and Mis4/Scc2 for normal spindle-kinetochore interaction in fission yeast
Y Toyoda; K Furuya; G Goshima; K Nagao; K Takahashi; M Yanagida
CURRENT BIOLOGY, Mar. 2002, Peer-reviewed
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase
T Tomonaga; K Nagao; Y Kawasaki; K Furuya; A Murakami; J Morishita; T Yuasa; T Sutani; SE Kearsey; F Uhlmann; K Nasmyth; M Yanagida
GENES & DEVELOPMENT, Nov. 2000, Peer-reviewed
Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase
K Tanaka; T Yonekawa; Y Kawasaki; M Kai; K Furuya; M Iwasaki; H Murakami; M Yanagida; H Okayama
MOLECULAR AND CELLULAR BIOLOGY, May 2000, Peer-reviewed
Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G(1) phase
K Furuya; K Takahashi; M Yanagida
GENES & DEVELOPMENT, Nov. 1998, Peer-reviewed
Misc.
ジャポニカス分裂酵母菌を用いた核膜動態の遺伝学的解析
青木敬太; 志波優; 高田啓; 古谷寛治; 古谷寛治; 吉川博文; 吉川博文; 仁木宏典
日本分子生物学会年会プログラム・要旨集(Web), 2011
A data-driven approach to a new frontier in chromatin biology
井倉毅; 古谷寛治; 白木琢磨; 井倉正枝
日本環境変異原ゲノム学会大会プログラム・要旨集, 2021
融合研究への挑戦:動的細胞老化を司るヒストン蛋白質の新知見
井倉毅; 古谷寛治; 白木琢磨; 井倉正枝
日本生化学会大会(Web), 2021
Fluctuation of protein complex against various genome stresses
Cdk-Plk axis to destabilize a checkpoint protein Rad9
Kanji Furuya
The 4D nucleome 2014, 17 Dec. 2014
Cdk-Plk axis to destabilize a checkpoint protein Rad9
Kanji Furuya
The 9th 3R symposium, 17 Nov. 2014
Phosphorylation on checkpoint protein Rad9 contribute to genomic stability
Kanji Furuya
日本放射線影響学会 第57回大会, 01 Oct. 2014
DNA修復・複製の連携役としてのチェックポイント機構とクロマチン制御の機能関連
古谷寛治
新学術領域 ゲノム普遍的制御 第5回領域班会議, 07 May 2014
チェックポイントタンパク質Rad9のリン酸化による動態制御
古谷寛治
第22回 DNA複製・組換え・修復ワークショップ, 04 Feb. 2014
The regulation of chromatin binding of Rad9 via its phosphorylation
Kanji Furuya
International Conference, Kyoto, 2014, “Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity”, 04 Feb. 2014
Phosphorylation on Rad9 checkpoint clamp protein contributes to genomic stability
Kanji Furuya
第36回日本分子生物学会年会、ワークショップ, 03 Dec. 2013
チェックポイントタンパク質Rad9のリン酸化による動態制御
古谷寛治
日本放射線影響学会第56回大会, 18 Oct. 2013
チェックポイントタンパク質のダイナミクス制御
古谷寛治
遺伝研研究集会「染色体DNAの安定維持の分子メカニズム」, 27 Sep. 2013
DNA修復・複製の連携役としてのチェックポイント機構とクロマチン制御の機能関連
古谷寛治
新学術領域 ゲノム普遍的制御 第4回領域班会議, 08 May 2013
チェックポイントタンパク質のダイナミクス制御
古谷寛治
日本分子生物学会年会、ワークショップ, 13 Dec. 2012
The regulation of checkpoint proteins by checkpoint kinase ATR and DNA replication kinase DDK
古谷寛治
分子生物学会年会, 16 Dec. 2011
DDK phosphorylates checkpoint clamp Rad9 and promotes its release from damaged Chromatin.
古谷寛治
分子生物学会年会, 08 Dec. 2010
DDK phosphorylates checkpoint clamp Rad9 and promotes its release from damaged Chromatin