Basic Information

Faculty

• Faculty of Science

Email Address

• Email Address

  aoki.kazuhiro.6vkyoto-u.ac.jp

Professional Memberships

• THE BIOPHYSICAL SOCIETY OF JAPAN
• THE JAPANESE CANCER ASSOCIATION
• 日本細胞生物学会
• 定量生物学の会
• 日本生化学会
• 日本分子生物学会

Academic Degree

• 25 Mar. 2004

  大阪大学修士（医科学）
• 23 Mar. 2007

  大阪大学博士（医学）

Academic Resume (Graduate Schools)

• 大阪大学, 大学院医学系研究科博士課程分子病態医学専攻, 修了
• 大阪大学, 大学院医学系研究科修士課程医科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 名古屋大学, 理学部物理学科, 卒業

Research History

• From Nov. 2023, To Present

  Kyoto University, Graduate School of Biostudies, Professor
• From Apr. 2019, To Mar. 2024

  National Institutes of Natural Sciences, International Research Collaboration Center, Quantitative and Imaging Biology, Professor
• From Apr. 2018, To Mar. 2024

  Nagoya City University, Graduate School of Pharmaceutical Sciences, Integrative Science for Dynamic Living Systems, Visiting Professor
• From Apr. 2018, To Present

  National Institutes of Natural Sciences, 定量生物学研究グループ, 教授（兼任）
• From Apr. 2016, To Present

  National Institutes of Natural Sciences, 定量生物学研究部門, 教授（兼任）
• From Apr. 2016, To Mar. 2018

  自然科学研究機構 岡崎統合バイオサイエンスセンター, 定量生物学研究部門, 教授
• From May 2013, To Mar. 2016

  Kyoto University, Graduate School of Medicine, 特定准教授
• From Jun. 2010, To Apr. 2013

  Kyoto University, Graduate School of Biostudies, 講師
• From Sep. 2009, To Mar. 2013

  科学技術振興機構 さきがけ, 研究員（兼任）
• From Aug. 2008, To May 2010

  Kyoto University, Graduate School of Biostudies, 助教
• From Apr. 2008, To Jul. 2008

  Kyoto University, Graduate School of Biostudies, 特定研究員
• From Apr. 2007, To Mar. 2008

  日本学術振興会 特別研究員（PD）
• From Apr. 2005, To Mar. 2007

  日本学術振興会 特別研究員（DC1）

Profile

• Profile

  細胞内シグナル伝達系を定量的に理解したいと考えています。

ID,URL

• External link

  http://kaken.nii.ac.jp/ja/r/80511427

researchmap URL

• https://researchmap.jp/kazuhiro_aoki

Research

Research Interests

• Optogenetics
• MAPキナーゼ
• Gタンパク質
• シグナル伝達
• Ras
• シミュレーション
• イメージング
• FRET

Research Areas

• Life sciences, Cell biology
• Life sciences, Medical biochemistry

Papers

• Opto-p53: A Light-Controllable p53 Signaling for Regulating p53-Dependent Cell Fate

  Tatsuki Tsuruoka; Yuhei Goto; Kazuhiro Aoki

  06 Apr. 2025

  
• Inverse signal importance in real exposome: How do biological systems dynamically prioritize multiple environmental signals?

  Thoma Itoh; Yohei Kondo; Tomoya Nakayama; Ai Shinomiya; Kazuhiro Aoki; Takashi Yoshimura; Honda Naoki

  04 Apr. 2025

  
• Network topology creates independent control of G2-M from G1-S checkpoints in the fission yeast cell cycle system

  Yuhei Yamauchi; Hironori Sugiyama; Yuhei Goto; Kazuhiro Aoki; Atsushi Mochizuki

  13 Mar. 2025

  
• Cellular Responses to Photothermal Therapy: Heat-Induced ERK Signaling and Intercellular Communication in Solid Tumors

  Farsai Taemaitree; Yuta Takano; Daisuke Yamaguchi; Kazushi Yamaguchi; Yudai Yamashita; Motosuke Tsutsumi; Chentao Wen; Kohei Otomo; Kenji Hirai; James Hutchison; Indra Van Zundert; Sandra Krzyzowska; Maria Bravo; Sayuki Hirano; Koutarou D Kimura; Kazuhiro Aoki; Susana Rocha; Tomomi Nemoto; Beatrice Fortuni; Hiroshi Uji-i

  03 Mar. 2025

  
• Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research

  Sachiya Nakashima; Aika Toyama; Hironori Sugiyama; Kazuhiro Aoki; Yuhei Goto

  Cell Structure and Function, 2025

  
• Dynamic behavior of cell-cell adhesion factors in collective cell migration.

  Sayuki Hirano; Kazuhiro Aoki; Naoto Ueno

  Cells & development, 23 Jan. 2025

  
• γ-Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells

  Kai Tahara; Akinobu Nakamura; Xiaotong Wang; Keishi Mitamura; Yuki Ichihashi; Keiko Kano; Emi Mishiro-Sato; Kazuhiro Aoki; Yasuteru Urano; Toru Komatsu; Shinya Tsukiji

  ACS Chemical Biology, 20 Nov. 2024

  
• Possible roles of CAHS proteins form Tardigrade in osmotic stress tolerance in mammalian cells

  Takahiro Bino; Yuhei Goto; Gembu Maryu; Kazuharu Arakawa; Kazuhiro Aoki

  Cell Structure and Function, 2024

  
• Quantification of Cyclin-CDK dissociation constants in living cells using fluorescence cross-correlation spectroscopy with green and near-infrared fluorescent proteins.

  Aika Toyama; Yuhei Goto; Yuhei Yamauchi; Hironori Sugiyama; Yohei Kondo; Atsushi Mochizuki; Kazuhiro Aoki

  15 Nov. 2024

  
• Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis

  Toshiyuki Sato; Yuting I. Li; David J. Jörg; Mitsuru Komeya; Hiroyuki Yamanaka; Hiroko Nakamura; Kodai Hirano; Yohei Kondo; Kazuhiro Aoki; Masahide Takahashi; Hiroki Nakata; Hiroshi Kimura; Takehiko Ogawa; Benjamin D. Simons; Shosei Yoshida

  04 Nov. 2024

  
• ZO-1 shuttles between tight junctions and podosomes by riding ERK activation waves during collective cell migration

  Sayuki Hirano; Yohei Kondo; Noriyuki Kinoshita; Tetsuhisa Otani; Mikio Furuse; Naoto Ueno; Kazuhiro Aoki

  09 Aug. 2024

  
• Revisiting the evolution of bow-tie architecture in signaling networks.

  Thoma Itoh; Yohei Kondo; Kazuhiro Aoki; Nen Saito

  NPJ systems biology and applications, 29 Jun. 2024, Peer-reviewed

  
• ErbB2/HER2 governs CDK4 inhibitor sensitivity and timing and irreversibility of G1/S transition by altering c-Myc and cyclin D function

  Ayaka Nagasato-Ichikawa; Ken Murakami; Kazuhiro Aoki; Mariko Okada

  14 May 2024

  
• A transcriptional program underlying the circannual rhythms of gonadal development in medaka

  Tomoya Nakayama; Miki Tanikawa; Yuki Okushi; Thoma Itoh; Tsuyoshi Shimmura; Michiyo Maruyama; Taiki Yamaguchi; Akiko Matsumiya; Ai Shinomiya; Ying-Jey Guh; Junfeng Chen; Kiyoshi Naruse; Hiroshi Kudoh; Yohei Kondo; Honda Naoki; Kazuhiro Aoki; Atsushi J. Nagano; Takashi Yoshimura

  Proceedings of the National Academy of Sciences, 18 Dec. 2023

  
• A genetically encoded red fluorescence dopamine biosensor enables dual imaging of dopamine and norepinephrine

  Chihiro Nakamoto; Yuhei Goto; Yoko Tomizawa; Yuko Fukata; Masaki Fukata; Kasper Harpsøe; David E. Gloriam; Kazuhiro Aoki; Tomonori Takeuchi

  26 May 2020

  
• Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

  Ellen H. Brumbaugh-Reed; Yang Gao; Kazuhiro Aoki; Jared E. Toettcher

  Nature Communications, 07 Aug. 2024, Peer-reviewed

  
• Live-cell fluorescence imaging and optogenetic control of PKA kinase activity in fission yeast Schizosaccharomyces pombe.

  Keiichiro Sakai; Kazuhiro Aoki; Yuhei Goto

  Yeast (Chichester, England), May 2024, Peer-reviewed

  
• Live-cell imaging defines a threshold in CDK activity at the G2/M transition.

  Hironori Sugiyama; Yuhei Goto; Yohei Kondo; Damien Coudreuse; Kazuhiro Aoki

  Developmental cell, 26 Feb. 2024, Peer-reviewed

  
• ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells.

  Moeka Ajiki; Masaru Yoshikawa; Tomoki Miyazaki; Asami Kawasaki; Kazuhiro Aoki; Fubito Nakatsu; Shinya Tsukiji

  RSC chemical biology, 05 Jun. 2024, Peer-reviewed

  
• Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast.

  Keiichiro Sakai; Yohei Kondo; Yuhei Goto; Kazuhiro Aoki

  Proceedings of the National Academy of Sciences of the United States of America, 25 Jun. 2024, Peer-reviewed, Last author, Corresponding author

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• Molecular Design of FRET Probes Based on Domain Rearrangement of Protein Disulfide Isomerase for Monitoring Intracellular Redox Status

  Maho Yagi-Utsumi; Haruko Miura; Christian Ganser; Hiroki Watanabe; Methanee Hiranyakorn; Tadashi Satoh; Takayuki Uchihashi; Koichi Kato; Kei-ichi Okazaki; Kazuhiro Aoki

  International Journal of Molecular Sciences, 16 Aug. 2023, Peer-reviewed, Last author, Corresponding author

  
• Stretching the limits of extracellular signal-related kinase (ERK) signaling - Cell mechanosensing to ERK activation.

  Tsuyoshi Hirashima; Naoya Hino; Kazuhiro Aoki; Michiyuki Matsuda

  Current opinion in cell biology, 11 Aug. 2023, Peer-reviewed, Invited, Corresponding author

  
• Chemogenetic Manipulation of Endogenous Proteins in Fission Yeast Using a Self-Localizing Ligand-Induced Protein Translocation System.

  Akinobu Nakamura; Yuhei Goto; Hironori Sugiyama; Shinya Tsukiji; Kazuhiro Aoki

  ACS chemical biology, 15 Dec. 2023

  
• Generation of pulsatile ERK activity in mouse embryonic stem cells is regulated by Raf activity.

  Yayoi Toyooka; Kazuhiro Aoki; Fumiko Matsukawa Usami; Sanae Oka; Azusa Kato; Toshihiko Fujimori

  Scientific reports, 10 Jun. 2023, Peer-reviewed

  
• Optimal inference of molecular interaction dynamics in FRET microscopy.

  Keita Kamino; Nirag Kadakia; Fotios Avgidis; Zhe-Xuan Liu; Kazuhiro Aoki; Thomas S Shimizu; Thierry Emonet

  Proceedings of the National Academy of Sciences of the United States of America, 11 Apr. 2023, Peer-reviewed

  
• Emergence of Bow-tie Architecture in Evolving Feedforward Networks

  Thoma Itoh; Yohei Kondo; Kazuhiro Aoki; Nen Saito

  29 Mar. 2023

  
• Live-cell imaging provides direct evidence for a threshold in CDK activity at the G2/M transition

  Hironori Sugiyama; Yuhei Goto; Yohei Kondo; Damien Coudreuse; Kazuhiro Aoki

  26 Mar. 2023

  
• Optical Control of Cell Signaling with Red/Far-Red Light-Responsive Optogenetic Tools in Caenorhabditis elegans.

  Shigekazu Oda; Emi Sato-Ebine; Akinobu Nakamura; Koutarou D Kimura; Kazuhiro Aoki

  ACS synthetic biology, 20 Feb. 2023, Peer-reviewed, Last author, Corresponding author

  
• Decoding cellular deformation from pseudo-simultaneously observed Rho GTPase activities.

  Katsuyuki Kunida; Nobuhiro Takagi; Kazuhiro Aoki; Kazushi Ikeda; Takeshi Nakamura; Yuichi Sakumura

  Cell reports, 03 Feb. 2023, Peer-reviewed

  
• In vivo expression vector derived from anhydrobiotic tardigrade genome enables live imaging in Eutardigrada

  Sae Tanaka; Kazuhiro Aoki; Kazuharu Arakawa

  Proceedings of the National Academy of Sciences, 31 Jan. 2023, Peer-reviewed

  
• A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.

  Naoya Hino; Kimiya Matsuda; Yuya Jikko; Gembu Maryu; Katsuya Sakai; Ryu Imamura; Shinya Tsukiji; Kazuhiro Aoki; Kenta Terai; Tsuyoshi Hirashima; Xavier Trepat; Michiyuki Matsuda

  Developmental cell, 26 Sep. 2022, Peer-reviewed

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• Quantitative live-cell imaging of GPCR downstream signaling dynamics.

  Ryosuke Tany; Yuhei Goto; Yohei Kondo; Kazuhiro Aoki

  The Biochemical journal, 29 Apr. 2022, Peer-reviewed, Last author, Corresponding author

  
• LIM Tracker: a software package for cell tracking and analysis with advanced interactivity

  Hideya Aragaki; Katsunori Ogoh; Yohei Kondo; Kazuhiro Aoki

  Scientific Reports, Feb. 2022, Peer-reviewed, Last author

  
• Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration.

  Shuhao Lin; Daiki Hirayama; Gembu Maryu; Kimiya Matsuda; Naoya Hino; Eriko Deguchi; Kazuhiro Aoki; Ryo Iwamoto; Kenta Terai; Michiyuki Matsuda

  Life science alliance, Jan. 2022, Peer-reviewed

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• Near-infrared imaging in fission yeast using a genetically encoded phycocyanobilin biosynthesis system.

  Keiichiro Sakai; Yohei Kondo; Hiroyoshi Fujioka; Mako Kamiya; Kazuhiro Aoki; Yuhei Goto

  Journal of cell science, 15 Dec. 2021, Peer-reviewed, Corresponding author

  
• Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis.

  Kei Yamamoto; Haruko Miura; Motohiko Ishida; Yusuke Mii; Noriyuki Kinoshita; Shinji Takada; Naoto Ueno; Satoshi Sawai; Yohei Kondo; Kazuhiro Aoki

  Nature communications, 08 Dec. 2021, Peer-reviewed, Last author, Corresponding author

  
• A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro.

  Chihiro Nakamoto; Yuhei Goto; Yoko Tomizawa; Yuko Fukata; Masaki Fukata; Kasper Harpsøe; David E Gloriam; Kazuhiro Aoki; Tomonori Takeuchi

  Molecular brain, 06 Dec. 2021, Peer-reviewed, Corresponding author

  
• 20 years of Developmental Cell: Looking forward.

  Takashi Hiiragi; Amy S Gladfelter; Irene Miguel-Aliaga; Hilary A Coller; On Sun Lau; Heidi M McBride; Kazuhiro Aoki; Andreas Linkermann; Stefano Santaguida; Geoffrey Wasteneys; Nicolas C Rivron; Marta N Shahbazi; Miki Ebisuya; Madeline A Lancaster

  Developmental cell, 06 Dec. 2021

  
• Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade.

  Maho Yagi-Utsumi; Kazuhiro Aoki; Hiroki Watanabe; Chihong Song; Seiji Nishimura; Tadashi Satoh; Saeko Yanaka; Christian Ganser; Sae Tanaka; Vincent Schnapka; Ean Wai Goh; Yuji Furutani; Kazuyoshi Murata; Takayuki Uchihashi; Kazuharu Arakawa; Koichi Kato

  Scientific reports, 04 Nov. 2021, Peer-reviewed

  
• Identification of ksg1 mutation showing long‐lived phenotype in fission yeast

  Kotaro Matsui; Keisuke Okamoto; Tomoka Hasegawa; Hokuto Ohtsuka; Takafumi Shimasaki; Kunio Ihara; Yuhei Goto; Kazuhiro Aoki; Hirofumi Aiba

  Genes to Cells, 17 Sep. 2021, Peer-reviewed

  
• Shedding light on developmental ERK signaling with genetically encoded biosensors.

  Akinobu Nakamura; Yuhei Goto; Yohei Kondo; Kazuhiro Aoki

  Development (Cambridge, England), 15 Sep. 2021, Peer-reviewed

  
• Multiplexed fluorescence imaging of GPCR downstream signaling dynamics at the single-cell level

  Ryosuke Tany; Yuhei Goto; Yohei Kondo; Kazuhiro Aoki

  22 Aug. 2021

  
• A self-exciting point process to study multicellular spatial signaling patterns.

  Archit Verma; Siddhartha G Jena; Danielle R Isakov; Kazuhiro Aoki; Jared E Toettcher; Barbara E Engelhardt

  Proceedings of the National Academy of Sciences of the United States of America, 10 Aug. 2021, Peer-reviewed

  
• Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems

  Farahani, P.E.; Reed, E.H.; Underhill, E.J.; Aoki, K.; Toettcher, J.E.

  Annual Review of Biomedical Engineering, 04 Jun. 2021, Peer-reviewed

  
• CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.

  Kentaro Kajiwara; Shotaro Yamano; Kazuhiro Aoki; Daisuke Okuzaki; Kunio Matsumoto; Masato Okada

  Life science alliance, Apr. 2021, Peer-reviewed

  
• 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images.

  Chentao Wen; Takuya Miura; Venkatakaushik Voleti; Kazushi Yamaguchi; Motosuke Tsutsumi; Kei Yamamoto; Kohei Otomo; Yukako Fujie; Takayuki Teramoto; Takeshi Ishihara; Kazuhiro Aoki; Tomomi Nemoto; Elizabeth Mc Hillman; Koutarou D Kimura

  eLife, 30 Mar. 2021, Peer-reviewed

  
• A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation

  Yuka Hatano; Sachio Suzuki; Akinobu Nakamura; Tatsuyuki Yoshii; Kyoko Atsuta-Tsunoda; Kazuhiro Aoki; Shinya Tsukiji

  Cell chemical biology, 16 Mar. 2021

  
• Hierarchical modeling of mechano-chemical dynamics of epithelial sheets across cells and tissue.

  Yoshifumi Asakura; Yohei Kondo; Kazuhiro Aoki; Honda Naoki

  Scientific reports, 18 Feb. 2021, Peer-reviewed

  
• Visualization and Manipulation of Intracellular Signaling

  Yuhei Goto; Yohei Kondo; Kazuhiro Aoki

  Advances in Experimental Medicine and Biology, Feb. 2021, Peer-reviewed, Invited

  
• Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction.

  Reina E Ito; Chitose Oneyama; Kazuhiro Aoki

  PloS one, 2021, Peer-reviewed, Last author, Corresponding author

  
• A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.

  Tomoki Yano; Kazuto Tsukita; Hatsuho Kanoh; Shogo Nakayama; Hiroka Kashihara; Tomoaki Mizuno; Hiroo Tanaka; Takeshi Matsui; Yuhei Goto; Akira Komatsubara; Kazuhiro Aoki; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  The EMBO journal, 21 Dec. 2020, Peer-reviewed

  
• Experimental evaluation of thermodynamic cost and speed limit in living cells via information geometry

  Keita Ashida; Kazuhiro Aoki; Sosuke Ito

  30 Nov. 2020

  
• Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics

  Youichi Uda; Haruko Miura; Yuhei Goto; Kei Yamamoto; Yusuke Mii; Yohei Kondo; Shinji Takada; Kazuhiro Aoki

  ACS Chemical Biology, 20 Nov. 2020, Peer-reviewed, Last author, Corresponding author

  
• Development of optogenetic tools to manipulate cell cycle checkpoints

  Yuhei Goto; Kazuhiro Aoki

  23 Jun. 2020

  
• ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization.

  Naoya Hino; Leone Rossetti; Ariadna Marín-Llauradó; Kazuhiro Aoki; Xavier Trepat; Michiyuki Matsuda; Tsuyoshi Hirashima

  Developmental cell, 22 Jun. 2020, Peer-reviewed

  
• Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells.

  Akinobu Nakamura; Choji Oki; Kenya Kato; Satoko Fujinuma; Gembu Maryu; Keiko Kuwata; Tatsuyuki Yoshii; Michiyuki Matsuda; Kazuhiro Aoki; Shinya Tsukiji

  ACS chemical biology, 17 Apr. 2020, Peer-reviewed

  
• Biophysical research in Okazaki, Japan.

  Shuji Akiyama; Kazuhiro Aoki; Yoshihiro Kubo

  Biophysical reviews, Apr. 2020, Peer-reviewed

  
• Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor.

  Hirokazu Yagi; Maho Yagi-Utsumi; Rena Honda; Yusaku Ohta; Taiki Saito; Miho Nishio; Satoshi Ninagawa; Kousuke Suzuki; Takahiro Anzai; Yukiko Kamiya; Kazuhiro Aoki; Mahito Nakanishi; Tadashi Satoh; Koichi Kato

  Nature communications, 13 Mar. 2020, Peer-reviewed

  
• CDCP1 controls compensatory renal growth by integrating Src and Met signaling

  Kajiwara K; Aoki K; Okuzaki D; Matsumoto K; Okada M

  bioRxiv, Oct. 2019

  
• Single-cell quantification of the concentrations and dissociation constants of endogenous proteins.

  Akira T Komatsubara; Yuhei Goto; Yohei Kondo; Michiyuki Matsuda; Kazuhiro Aoki

  The Journal of biological chemistry, 12 Apr. 2019, Peer-reviewed, Last author, Corresponding author

  
• Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death.

  Haruko Miura; Yohei Kondo; Michiyuki Matsuda; Kazuhiro Aoki

  Cell reports, 04 Sep. 2018, Peer-reviewed, Last author, Corresponding author

  
• Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.

  Yu Muta; Yoshihisa Fujita; Kenta Sumiyama; Atsuro Sakurai; M Mark Taketo; Tsutomu Chiba; Hiroshi Seno; Kazuhiro Aoki; Michiyuki Matsuda; Masamichi Imajo

  Nature communications, 05 Jun. 2018, Peer-reviewed

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• Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters.

  Gembu Maryu; Haruko Miura; Youichi Uda; Akira T Komatsubara; Michiyuki Matsuda; Kazuhiro Aoki

  Cell structure and function, 25 Apr. 2018, Peer-reviewed, Last author, Corresponding author

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• Inverse tissue mechanics of cell monolayer expansion.

  Yohei Kondo; Kazuhiro Aoki; Shin Ishii

  PLoS Comput. Biol., 2018, Peer-reviewed

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• Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling.

  Youichi Uda; Yuhei Goto; Shigekazu Oda; Takayuki Kohchi; Michiyuki Matsuda; Kazuhiro Aoki

  Proceedings of the National Academy of Sciences of the United States of America, 07 Nov. 2017, Peer-reviewed, Last author, Corresponding author

  
• Propagating Wave of ERK Activation Orients Collective Cell Migration.

  Kazuhiro Aoki; Yohei Kondo; Honda Naoki; Toru Hiratsuka; Reina E Itoh; Michiyuki Matsuda

  Developmental cell, 06 Nov. 2017, Peer-reviewed, Corresponding author

  
• Corrigendum: Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo.

  Kamezaki A; Sato F; Aoki K; Asakawa K; Kawakami K; Matsuzaki F; Sehara-Fujisawa A

  Scientific reports, Apr. 2017, Peer-reviewed

  
• Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules

  Masataka Yamao; Kazuhiro Aoki; Naoto Yukinawa; Shin Ishii; Michiyuki Matsuda; Honda Naoki

  PLOS ONE, Oct. 2016, Peer-reviewed

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• Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo

  Aosa Kamezaki; Fuminori Sato; Kazuhiro Aoki; Kazuhide Asakawa; Koichi Kawakami; Fumio Matsuzaki; Atsuko Sehara-Fujisawa

  SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed

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• Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

  Kanako Inaba; Katsutoshi Oda; Kazuhiro Aoki; Kenbun Sone; Yuji Ikeda; Aki Miyasaka; Tomoko Kashiyama; Tomohiko Fukuda; Chinami Makii; Takahide Arimoto; Osamu Wada-Hiraike; Kei Kawana; Tetsu Yano; Yutaka Osuga; Tomoyuki Fujii

  ONCOTARGET, May 2016, Peer-reviewed

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• Variegated RHOA mutations in adult T-cell leukemia/lymphoma

  Yasunobu Nagata; Kenji Kontani; Terukazu Enami; Keisuke Kataoka; Ryohei Ishii; Yasushi Totoki; Tatsuki R. Kataoka; Masahiro Hirata; Kazuhiro Aoki; Kazumi Nakano; Akira Kitanaka; Mamiko Sakata-Yanagimoto; Sachiko Egami; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Yusuke Shiozawa; Tetsuichi Yoshizato; Hiromichi Suzuki; Ayana Kon; Kenichi Yoshida; Yusuke Sato; Aiko Sato-Otsubo; Masashi Sanada; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Satoru Miyano; Osamu Nureki; Tatsuhiro Shibata; Hironori Haga; Kazuya Shimoda; Toshiaki Katada; Shigeru Chiba; Toshiki Watanabe; Seishi Ogawa

  BLOOD, Feb. 2016, Peer-reviewed

  
• Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression

  Gembu Maryu; Michiyuki Matsuda; Kazuhiro Aoki

  CELL STRUCTURE AND FUNCTION, 2016, Peer-reviewed, Last author, Corresponding author

  
• Quantification of dissociation constant in living cells by fluorescence cross-correlation spectroscopy

  Aoki Kazuhiro

  Folia Pharmacologica Japonica, 2016, Peer-reviewed

  
• Distinct predictive performance of Rac1 and Cdc42 in cell migration

  Masataka Yamao; Honda Naoki; Katsuyuki Kunida; Kazuhiro Aoki; Michiyuki Matsuda; Shin Ishii

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

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• Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer

  Akira T. Komatsubara; Michiyuki Matsuda; Kazuhiro Aoki

  SCIENTIFIC REPORTS, Aug. 2015, Peer-reviewed, Last author, Corresponding author

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• mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

  N. Komatsu; Y. Fujita; M. Matsuda; K. Aoki

  Oncogene, 23 Feb. 2015, Peer-reviewed, Last author, Corresponding author

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• Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

  Toru Hiratsuka; Yoshihisa Fujita; Honda Naoki; Kazuhiro Aoki; Yuji Kamioka; Michiyuki Matsuda

  ELIFE, Feb. 2015, Peer-reviewed

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• Visualization of intracellular signaling with fluorescence resonance energy transfer-based biosensors

  Aoki, K.

  Protein Modifications in Pathogenic Dysregulation of Signaling, 2015

  
• Quantitative In Vivo Fluorescence Cross-Correlation Analyses Highlight the Importance of Competitive Effects in the Regulation of Protein-Protein Interactions

  Wakako Sadaie; Yoshie Harada; Michiyuki Matsuda; Kazuhiro Aoki

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2014, Peer-reviewed, Last author, Corresponding author

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• Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

  Yoshihisa Fujita; Naoki Komatsu; Michiyuki Matsuda; Kazuhiro Aoki

  FEBS JOURNAL, Jul. 2014, Peer-reviewed, Last author, Corresponding author

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• Development of a FRET Biosensor with High Specificity for Akt

  Haruko Miura; Michiyuki Matsuda; Kazuhiro Aoki

  CELL STRUCTURE AND FUNCTION, 2014, Peer-reviewed, Last author, Corresponding author

  
• Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

  Kazuhiro Aoki; Yuka Kumagai; Atsuro Sakurai; Naoki Komatsu; Yoshihisa Fujita; Clara Shionyu; Michiyuki Matsuda

  Molecular Cell, 21 Nov. 2013, Peer-reviewed, Corresponding author

  
• Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing

  Kazuhiro Aoki; Yuji Kamioka; Michiyuki Matsuda

  Development Growth and Differentiation, May 2013, Peer-reviewed, Corresponding author

  
• A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media

  Kazuhiro Aoki; Koichi Takahashi; Kazunari Kaizu; Michiyuki Matsuda

  SCIENTIFIC REPORTS, Mar. 2013, Peer-reviewed, Corresponding author

  
• FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

  Katsuyuki Kunida; Michiyuki Matsuda; Kazuhiro Aoki

  JOURNAL OF CELL SCIENCE, May 2012, Peer-reviewed, Last author, Corresponding author

  
• Stable expression of FRET biosensors: A new light in cancer research

  Kazuhiro Aoki; Naoki Komatsu; Eishu Hirata; Yuji Kamioka; Michiyuki Matsuda

  CANCER SCIENCE, Apr. 2012, Peer-reviewed

  
• Visualization of protein kinase activities in living cells

  Aoki, K.; Komatsu, N.; Goto, A.; Matsuda, M.

  Neuromethods, 2012

  
• Computational simulation based on experimentally-determined kinetic parameters in signal transduction

  Kazuhiro Aoki

  Seikagaku, 2012, Peer-reviewed

  
• Development of an optimized backbone of FRET biosensors for kinases and GTPases

  Naoki Komatsu; Kazuhiro Aoki; Masashi Yamada; Hiroko Yukinaga; Yoshihisa Fujita; Yuji Kamioka; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2011, Peer-reviewed, Corresponding author

  Access this paper :

  
• Processive phosphorylation of ERK MAP kinase in mammalian cells

  Kazuhiro Aoki; Masashi Yamada; Katsuyuki Kunida; Shuhei Yasuda; Michiyuki Matsuda

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2011, Peer-reviewed, Corresponding author

  Access this paper :

  
• SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility

  Maria Carla Parrini; Amel Sadou-Dubourgnoux; Kazuhiro Aoki; Katsuyuki Kunida; Marco Biondini; Anastassia Hatzoglou; Patrick Poullet; Etienne Formstecher; Charles Yeaman; Michiyuki Matsuda; Carine Rosse; Jacques Camonis

  MOLECULAR CELL, Jun. 2011, Peer-reviewed

  
• 3K1346 Identification of feedback loops regulating stochastic cell migration by FRET imaging and statistical signal processing(Cell biology 4,The 49th Annual Meeting of the Biophysical Society of Japan)

  Kunida Katsuyuki; Aoki Kazuhiro; Matsuda Michiyuki

  Seibutsu Butsuri, 2011

  
• Spatiotemporal Regulation of Small GTPases as Revealed by Probes Based on the Principle of Forster Resonance Energy Transfer (FRET): Implications for Signaling and Pharmacology

  Etsuko Kiyokawa; Kazuhiro Aoki; Takeshi Nakamura; Michiyuki Matsuda

  ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011, 2011, Peer-reviewed

  
• Revolving movement of a dynamic cluster of actin filaments during mitosis

  Masaru Mitsushima; Kazuhiro Aoki; Miki Ebisuya; Shigeru Matsumura; Takuya Yamamoto; Michiyuki Matsuda; Fumiko Toyoshima; Eisuke Nishida

  JOURNAL OF CELL BIOLOGY, Nov. 2010, Peer-reviewed

  
• Multiple Decisive Phosphorylation Sites for the Negative Feedback Regulation of SOS1 via ERK

  Yuji Kamioka; Shuhei Yasuda; Yoshihisa Fujita; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Peer-reviewed

  
• The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

  Rie Matsunaga-Udagawa; Yoshihisa Fujita; Sayaka Yoshiki; Kenta Terai; Yuji Kamioka; Etsuko Kiyokawa; Katsuyuki Yugi; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2010, Peer-reviewed, Corresponding author

  
• Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

  Sayaka Yoshiki; Rie Matsunaga-Udagawa; Kazuhiro Aoki; Yuji Kamioka; Etsuko Kiyokawa; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2010, Peer-reviewed

  
• 1P230 1C1355 Identification of molecular network based on FRET imaging and statistical signal processing in randomly migrating HT1080 cells(Cell biology,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

  Kunida Katsuyuki; Aoki Kazuhiro; Matsuda Michiyuki

  Seibutsu Butsuri, 2010

  
• On the Synchrony of Morphological and Molecular Signaling Events in Cell Migration

  Justin Dauwels; Yuki Tsukada; Yuichi Sakumura; Shin Ishii; Kazuhiro Aoki; Takeshi Nakamura; Michiyuki Matsuda; Francois Vialatte; Andrzej Cichocki

  ADVANCES IN NEURO-INFORMATION PROCESSING, PT I, 2009, Peer-reviewed

  
• Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

  Kazuhiro Aoki; Michiyuki Matsuda

  NATURE PROTOCOLS, 2009, Peer-reviewed

  
• Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells

  Teruko Nishioka; Kazuhiro Aoki; Kazuhiro Hikake; Hisayoshi Yoshizaki; Etsuko Kiyokawa; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Oct. 2008, Peer-reviewed

  
• FRET imaging and in silico simulation: analysis of the signaling network of nerve growth factor-induced neuritogenesis

  Takeshi Nakamura; Kazuhiro Aoki; Michiyuki Matsuda

  BRAIN CELL BIOLOGY, Aug. 2008, Peer-reviewed

  
• Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF

  Reina E. Itoh; Etsuko Kiyokawa; Kazuhiro Aoki; Teruko Nishioka; Tetsu Akiyama; Michiyuki Matsuda

  JOURNAL OF CELL SCIENCE, Aug. 2008, Peer-reviewed

  
• Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Forster resonance energy transfer

  Kazuhiro Aoki; Etsuko Kiyokawa; Takeshi Nakamura; Michiyuki Matsuda

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Jun. 2008, Peer-reviewed

  
• Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking.

  Yuki Tsukada; Kazuhiro Aoki; Takeshi Nakamura; Yuichi Sakumura; Michiyuki Matsuda; Shin Ishii

  PLoS Comput. Biol., 2008, Peer-reviewed

  
• Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

  Shu Hisata; Toshiaki Sakisaka; Takeshi Baba; Tomohiro Yamada; Kazuhiro Aoki; Mlchiyuki Matsuda; Yoshimi Takai

  JOURNAL OF CELL BIOLOGY, Aug. 2007, Peer-reviewed

  
• An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells

  Kazuhiro Aoki; Takeshi Nakamura; Takanari Inoue; Tobias Meyer; Michiyuki Matsuda

  JOURNAL OF CELL BIOLOGY, Jun. 2007, Peer-reviewed

  
• Regulation of RaIA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes

  H. Yoshizaki; K. Aoki; T. Nakamura; M. Matsuda

  BIOCHEMICAL SOCIETY TRANSACTIONS, Nov. 2006, Peer-reviewed

  
• GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion

  Kazuho Kawase; Takeshi Nakamura; Akiyuki Takaya; Kazuhiro Aoki; Kazuhiko Namikawa; Hiroshi Kiyama; Shuichiro Inagaki; Hiroshi Takemoto; Alan R. Saltiel; Michiyuki Matsuda

  DEVELOPMENTAL CELL, Sep. 2006, Peer-reviewed

  
• Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes

  A Fujioka; K Terai; RE Itoh; K Aoki; T Nakamura; S Kuroda; E Nishida; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2006, Peer-reviewed

  
• Monitoring spatio-temporal regulation of Ras and Rho GTPases with GFP-based FRET probes

  T Nakamura; K Aoki; M Matsuda

  METHODS, Oct. 2005, Peer-reviewed

  
• FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain

  T Nakamura; K Aoki; M Matsuda

  MOLECULAR BRAIN RESEARCH, Oct. 2005, Peer-reviewed

  
• Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells

  K Kurokawa; T Nakamura; K Aoki; M Matsuda

  BIOCHEMICAL SOCIETY TRANSACTIONS, Aug. 2005, Peer-reviewed

  
• Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells

  K Aoki; T Nakamura; K Fujikawa; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, May 2005, Peer-reviewed

  
• Improvement of the bioluminescence reporter system for real-time monitoring of circadian rhythms in the cyanobacterium Synechocystis sp strain PCC 6803

  K Kucho; K Aoki; S Itoh; M Ishiura

  GENES & GENETIC SYSTEMS, Feb. 2005, Peer-reviewed

  
• Dynamics of rho-family G proteins as visualized with FRET-based probes

  Y. Hisayoshi; A. Kazuhiro; M. Naoki; M. Matsuda

  Folia Pharmacologica Japonica, 2005, Peer-reviewed

  
• Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells

  K Aoki; T Nakamura; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2004, Peer-reviewed

  

Misc.

• 【蛍光タンパク質センサー】GPCRリガンドセンサーの開発

  後藤 祐平; 青木 一洋

  細胞, Apr. 2023

  
• 思春期

  Kazuhiro AOKI

  Seibutsu Butsuri, 2022, Invited, Lead author, Last author, Corresponding author

  
• 【生物物理学の進歩-生命現象の定量的理解へ向けて】細胞レベル 情報理論による真核細胞の情報伝達機構の解析

  近藤 洋平; 青木 一洋

  生体の科学, Jun. 2021

  
• ライブセルイメージングによる細胞内シグナル伝達の可視化と光操作

  後藤 祐平; 青木 一洋

  顕微鏡, 2021, Invited, Corresponding author

  
• Mechanism of specific glycosylation of glycoproteins tagged with a passport sequence

  山田梨乃; 矢木宏和; 戸島拓郎; 青木一洋; 本田怜奈; 矢木真穂; 矢木真穂; 足達俊吾; 加藤晃一; 加藤晃一

  日本糖質学会年会要旨集, 2021

  
• Unleashing mechanical constraint switches growth factor signaling dynamics underlying leader cell specification during collective cell migration

  日野直也; 松田樹生也; 真流玄武; 酒井克也; 酒井克也; 今村龍; 今村龍; 青木一洋; 寺井健太; 平島剛志; 平島剛志; 松本邦夫; 松本邦夫; 松田道行; 松田道行

  日本細胞生物学会大会(Web), 2021

  
• Development of phycocyanobilin biosynthesizing mice for optogenetic manipulation by red/far-red light

  小鉢健樹; 隅山健太; 青木一洋; 松田道行; 寺井健太

  日本細胞生物学会大会(Web), 2021

  
• Redundant roles of EGF ligands in the propagation of ERK activation wave and collective cell migration of MDCK cells

  LIN Shuhao; 平山大記; 日野直也; 真流玄武; 岩本亮; 青木一洋; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 集団細胞遊走における細胞層の自由端依存的なHGF感受性上昇による先導細胞の運命決定

  日野直也; 真流玄武; 青木一洋; 寺井健太; 平島剛志; 平島剛志; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 細胞の集団遊走におけるErbBファミリーの機能

  松田樹生也; 真流玄武; 平山大記; 日野直也; 青木一洋; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• Optical Manipulation of Intracellular Signal Transduction by Red/Far-Red Light with Phytochrome B

  青木 一洋

  光学 = Japanese journal of optics : publication of the Optical Society of Japan, Jan. 2020

  
• ERK MAPキナーゼによる細胞増殖と細胞集団運動の制御

  青木一洋; 青木一洋

  生化学, 25 Feb. 2019

  
• Red/far-red Light-induced Control of Intracellular Signaling in Mammalian Cells

  GOTO Yuhei; AOKI Kazuhiro

  Seibutsu Butsuri, 2019

  
• CHAPTER 7: Optogenetic Tools for Quantitative Biology: The Genetically Encoded PhyB-PIF Light-inducible Dimerization System and Its Application for Controlling Signal Transduction

  Oda, S.; Uda, Y.; Goto, Y.; Miura, H.; Aoki, K.

  Comprehensive Series in Photochemical and Photobiological Sciences, 2019, Peer-reviewed, Invited

  
• 光学顕微鏡 9.蛍光顕微鏡 iv.FRET

  青木一洋; 青木一洋

  実験医学, 15 Dec. 2018

  
• 【生きてるものは全部観る!イメージングの選び方・使い方100+】(第1章)光学顕微鏡 蛍光顕微鏡 FRET

  青木 一洋

  実験医学, Dec. 2018

  
• クローズアップ実験法 series301 細胞外からの発色団添加を必要としない赤色光/近赤外光によるシグナル伝達系の光操作

  青木一洋; 青木一洋; 宇田耀一; 宇田耀一; 小田茂和; 後藤祐平

  実験医学, 01 Aug. 2018

  
• 細胞多様性解明に資する光技術―見て,動かす IV.狙ったものを動かす 光誘導性二量体化による細胞内シグナル伝達経路の操作

  青木一洋; 宇田燿一; 小田茂和

  生体の科学, 15 Oct. 2017

  
• 生命科学・医学研究における事例に学ぶ II.シグナル伝達 5.確率的なERK活性化と細胞間伝搬現象の数理モデル

  青木一洋

  実験医学, 15 Mar. 2017

  
• Intercellular propagation of ERK MAP kinase signal transduction

  青木 一洋; 平塚 徹; 松田 道行

  生体の科学, Mar. 2016

  
• 細胞シグナル操作法 I.分子からみたシグナル操作法 3.キナーゼ 古典的MAPキナーゼ経路

  青木一洋

  生体の科学, 15 Oct. 2015

  
• 理論生物学―数理科学の医学への応用 螢光イメージングによる細胞増殖機構の定量解析

  青木一洋

  医学のあゆみ, 20 Jun. 2015

  
• Quantitative analysis of cell proliferation by fluorescence imaging

  青木 一洋

  医学のあゆみ, 20 Jun. 2015

  
• 生命動態システム科学 II.数理生物学 8.ネットワーク(3)細胞内情報伝達系の定量的なシミュレーション

  青木一洋

  生体の科学, 15 Oct. 2014

  
• 癌研究におけるFRETイメージング

  青木一洋

  月刊細胞, 20 Aug. 2014

  
• 定量的FRETイメージングによる細胞運動メカニズムの解明 バイオイメージ・インフォマティクスの研究事例として

  国田勝行; 青木一洋

  画像ラボ, 10 Jun. 2014

  
• バイオ・メディカル分野におけるビジョン技術 蛍光顕微鏡によるバイオイメージングの現状

  青木一洋

  画像ラボ, 10 May 2014

  
• 細胞の少数性と多様性に挑む―シングルセルアナリシス A.シングルセルアナリシスへ向けた技術開発 FRETバイオセンサーによるERK活性の単一細胞解析

  青木一洋

  生体の科学, 15 Apr. 2014

  
• Single cell analysis of ERK MAP kinase activity with a FRET biosensor

  青木 一洋

  生体の科学, Mar. 2014

  
• 数理的アプローチで迫るがんの本当の姿 定量的パラメータで見るがんのシグナルの本当の姿

  青木一洋

  実験医学, 01 Nov. 2013

  
• ポストゲノムプロジェクトとオーミクス研究の潮流 8.蛍光生体イメージングを用いてがん細胞の個性に迫る

  幸長弘子; 青木一洋; 松田道行

  実験医学, 10 Sep. 2013

  
• 3-4 Identification of Molecular Network Regulating the Random Cell Migration Based on the Quantitative FRET Imaging and Mathematical Modeling(3. Study Examples of the Bioimage Informatics,Bioimage Informatics)

  Kunida Katsuyuki; Aoki Kazuhiro

  The journal of the Institute of Image Information and Television Engineers, 01 Sep. 2013

  
• 2-1 Bioimaging with Fluorescence Microscopy(2. Bioimaging Technologies,Bioimage Informatics)

  Aoki Kazuhiro

  The journal of the Institute of Image Information and Television Engineers, 01 Sep. 2013

  
• Effects of Molecular Crowding on Processive Phosphorylation of ERK MAP Kinase

  AOKI KAZUHIRO

  生物物理, 25 Nov. 2012

  
• 実測パラメーターに基づく細胞内シグナル伝達系の定量的シミュレーション これまで見えてこなかった反応やモデルを精度よくあぶり出す

  青木一洋; 青木一洋

  化学と生物, 01 May 2012

  
• 「蛍光生物学」の最前線 5‐1 FRETバイオセンサーの最近の進歩

  青木一洋; 松田道行

  Dojin News, 05 Apr. 2012

  
• Computational simulation based on experimentally-determined kinetic parameters in signal transduction

  青木 一洋

  生化学, Apr. 2012

  
• 蛍光タンパク質を利用した腫瘍内pH環境の in vivo イメージング

  田中 正太郎; 青木 一洋; 上岡 裕治; 原田 浩; 平岡 真寛

  バイオイメージング, 15 Jul. 2009

  
• FRET imaging and in silico analysis of nerve growth factor-induced neurite outgrowth

  T. Nakamura; K. Aoki; M. Matsuda

  INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Dec. 2008

  
• Analysis of signal transduction of neuritogenesis using FRET imaging

  中村 岳史; 青木 一洋; 松田 道行

  The Cell, Apr. 2008

  
• FRET imaging and in silico analysis of NGF-induced neurite outgrowth signaling

  Takeshi Nakamura; Kazuhiro Aoki; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2008

  
• FRETの基礎と応用(D.GFPイメージング)

  中村 岳史; 青木 一洋; 松田 道行

  組織細胞化学, 10 Jul. 2007

  
• 蛋白質の時空間情報--シミュレーション構築のための必須パラメータを求めて (第1土曜特集 システム生物医学) -- (システム生物医学のための方法論)

  松田 道行; 青木 一洋

  医学のあゆみ, 02 Dec. 2006

  
• FRETプローブによるシグナル伝達分子の時空間的解析 (特集 プロテオミクスの細胞機能解析への挑戦)

  青木 一洋; 松田 道行

  細胞工学, Jun. 2006

  
• FRETプローブによるRhoファミリーGタンパク質の細胞内動態イメージング

  吉崎 尚良; 青木 一洋; 望月 直樹; 松田 道行

  日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA, 01 Aug. 2005

  
• Improvement of the biolumineseence reporter system for real-time monitoring of circadian rhythms in the cyanobacterium Synechocystis sp. strain PCC 6803 (vol 80, pg 19, 2005)

  K Kucho; K Aoki; S Itoh; M Ishiura

  GENES & GENETIC SYSTEMS, Jun. 2005

  
• Ras/ERK MAPKカスケードのダイナミクス

  藤岡亜紀; 寺井健太; 伊藤玲奈; 青木一洋; 中村岳史; 黒田真也; 西田栄介; 松田道行

  日本分子生物学会年会講演要旨集, 2005

  
• Local accumulation of PIP3 at plasma membrane recruits Vav2/Vav3 to activate Rac1/Cdc42 and to initiate outgrowth in NGF-stimulated PC12 cells

  K Aoki; T Nakamura; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2004

  

Presentations

• Cytoplasmic fluidization triggers dormancy breaking in fission yeast spores

  Kazuhiro Aoki

  RIKEN BDR Symposium 2025 Towards Redesigning Lifecycles, 05 Mar. 2025, Invited

  
• 蛍光イメージングと光遺伝学による 細胞周期の定量解析

  青木 一洋

  大阪大学・ニコンイメージングセンターシリーズセミナー第27回, 10 Jan. 2025, Invited

  
• ZO-1 shuttles between tight junctions and podosomes by riding ERK activation waves during collective cell migration

  Kazuhiro Aoki

  Kyoto University International Symposium“Dynamics in Cell Communications, 04 Dec. 2024, Invited

  
• Toward understanding the physical characteristics of cells and their significance

  Kazuhiro Aoki

  MathHuB 2024 / Mathematical Human Biology of Shape and Movement, 20 Nov. 2024, Invited

  
• Quantitative analysis of cell surface tension and cytoplasmic fluidity in cytokinesis and dormancy by live-cell imaging.

  Kazuhiro Aoki

  The 52nd Naito Conference on Frontiers of Physical and Mechanical Biology, 02 Oct. 2024, Invited

  
• Imaging cell state transition of vegetative and spores in fission yeast.

  Kazuhiro Aoki

  日本放射線影響学会第67回大会第12回日本放射線事故・災害医学会 年次学術集会合同大会, 27 Sep. 2024, Invited

  
• Quantitative analysis of cell cycle by using live cell imaging and optogenetics

  Kazuhiro Aoki

  PoL Seminar at TU Dresden, 06 Sep. 2024

  
• Optogenetics and live cell imaging visualize the dynamic regulation of cell surface tension and cell-cell junctions

  Kazuhiro Aoki

  EMBO Workshop Imaging mouse development, 04 Sep. 2024, Invited

  
• Cytoplasmic fluidization triggers breaking spore dormancy in fission yeast

  Kazuhiro Aoki

  Mechanical Control of Biological Self-organization, 17 Jun. 2024

  
• 蛍光イメージングによる細胞周期の定量解析

  青木一洋

  「集え、多分野研究者！」 感染症キャンプin 宮崎, 27 Jan. 2024, Invited

  
• Quantitative analysis of mechanical properties and their biological functions using live cell imaging and optogenetics

  Kazuhiro AOKI

  INFORMATION PHYSICS IN LIVING SYSTEMS, 09 Jan. 2024, Invited

  
• Live cell imaging of cell signaling and cell fate decision

  Kazuhiro AOKI

  Exploratory Research Center on Life and Living Systems (ExCELLS) and KAIST Sympoisum on Complex Biological Systems (Japan-Korea Collaborative Symposium), 24 Nov. 2023

  
• 蛍光イメージングと光遺伝学による細胞周期の定量解析

  青木一洋

  第32回日本バイオイメージング学会学術集会, 03 Nov. 2023, 日本バイオイメージング学会, Invited

  
• Genetically encoded phycocyanobilin synthesis, SynPCB, and its application to optogenetics and live-cell imaging.

  Kazuhiro AOKI

  15th International Conference on Tetrapyrrole Photoreceptors in Photosynthetic Organisms (ICTPPO2023), 21 Sep. 2023, Invited

  
• 生細胞イメージングと光遺伝学を使った細胞の力学的特性と生物学的機能の解析

  青木一洋

  日本物理学会 第78回年次大会, 16 Sep. 2023, 日本物理学会, Invited

  
• 生細胞蛍光イメ―ジングによる可視化と光操作

  青木一洋

  イメージングブートキャンプ2023, 12 Sep. 2023, 北海道大学大学院医学研究院 細胞生理学教室, Invited

  
• 生細胞イメージングによるGPCRシグナルの動的符号化原理の解明

  青木一洋

  生体機能と創薬シンポジウム2023, 24 Aug. 2023, 日本薬学会 薬理系薬学部会, Invited

  
• Quantitative analysis of cell cycle by live-cell imaging and optogenetics

  Kazuhiro Aoki

  The 3rd NINS-Princeton Joint Symposium EMERGING LIFE SCIENCES, 23 Mar. 2023, Invited

  
• 蛍光プローブと光遺伝学を用いた細胞周期の定量解析

  青木一洋

  イメージングブートキャンプ2022, 19 Jan. 2023, Invited

  
• 細胞内シグナル伝達系の可視化と光操作

  青木一洋

  EVIDENT Creative Forum 2023 Online 『次世代研究者と語る、これからのライブイメージング - New ERA of Live Cell Imaging with EVIDENT -』, 04 Jan. 2023, Invited

  
• Live-cell imaging illuminates the dynamic encoding of GPCR signaling

  Kazuhiro Aoki

  第45回日本分子生物学会年会, 02 Dec. 2022, Invited

  
• p38を介したJNKの阻害による確率的な細胞死

  青木 一洋

  第3回 細胞死コロキウム, 17 Nov. 2022, Invited

  
• Optical control of cell signaling with red/far-red light-responsive optogenetic tools in Caenorhabditis elegans.

  Kazuhiro Aoki

  The 8th IMCR Symposium on Endocrine and Metabolism: Beyond the Frontiers of Endocrinology & Metabolism, 10 Nov. 2022, Invited

  
• Optical relaxation of actomyosin contractility

  Kazuhiro AOKI

  the 15th Asia Pacific Physics Conference (APPC15), 21 Aug. 2022, Invited

  
• Visualization and manipulation of cell cycle regulation by live-cell imaging and optogenetics

  Kazuhiro AOKI

  Cell State Transitions: Approaches, Experimental Systems and Models, 26 Jul. 2022, Invited

  
• Live-cell imaging illuminates the dynamical encoding of GPCR signaling

  Kazuhiro AOKI

  第74回日本細胞生物学会大会, 30 Jun. 2022, Invited

  
• cAMP/PKA経路依存的な分裂酵母胞子の固体化の解消

  酒井 啓一郎; 後藤 祐平; 青木 一洋

  第74回日本細胞生物学会大会, 28 Jun. 2022

  
• GPCR下流シグナルダイナミクスの定量的ライブセルイメージング

  谷猪遼介; 後藤祐平; 近藤洋平; 青木一洋

  第74回日本細胞生物学会大会, 28 Jun. 2022

  
• Encoding and Decoding Biological Information

  Kazuhiro AOKI

  The 10th Japanese-French Frontiers of Science (JFFoS2022) symposium, 25 Jun. 2022, Invited

  
• 細胞内シグナル伝達系の可視化と操作

  青木一洋

  物性研ワークショップ「開放系トポロジーと生体・量子・統計物理」, 29 Mar. 2022, Invited

  
• SLIPT-PM: A new versatile chemogenetic platform for controlling plasma membrane signaling

  Sachio Suzuki; Yuka Hatano; Akinobu Nakamura; Kazuhiro Aoki; Shinya Tsukiji

  ACS Spring 2022, 22 Mar. 2022

  
• シグナル伝達ネットワークのbowtie構造の進化原理の探索

  伊藤冬馬; 青木一洋; 近藤洋平; 斉藤稔

  日本物理学会 第77回年次大会, 15 Mar. 2022

  
• 定量生物学の現状と展望

  青木一洋

  第３３回 生物学技術研究会, 17 Feb. 2022, Invited

  
• Optogenetic Relaxation of Actomyosin Contractility Uncovers Mechanistic Roles of Cortical Tension during Cytokinesis.

  Kazuhiro AOKI

  10th Tokyo Tech International Symposium on Life Science and Technology, 13 Jan. 2022, Invited

  
• Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

  Kei Yamamoto; Haruko Miura; Yohei Kondo; Kazuhiro Aoki

  The 51st NIPS International Symposium, 06 Dec. 2021

  
• Optical control of cell signaling in cultured cells, fission yeast, and worms

  Kazuhiro AOKI

  第59回生物物理学会年会, 26 Nov. 2021, Invited

  
• Multiplexed fluorescence imaging illuminates the dynamical encoding of GPCR signaling

  青木一洋

  第94回日本生化学会大会, 05 Nov. 2021, Invited

  
• Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

  Kei Yamamoto; Haruko Miura; Yohei Kondo; Kazuhiro Aoki

  第59回日本生物物理学会, 05 Nov. 2021

  
• 合成化合物の細胞内分解：酵素同定と一般性評価

  田原海; 中村彰伸; 市橋祐樹; 浦野泰照; 小松徹; 築地真也

  第52回中部化学関係学協会支部連合秋季大会, 31 Oct. 2021

  
• 細胞膜シグナル制御のための汎用的な化学遺伝学ツールの開発

  鈴木祥央; 波多野結香; 中村彰伸; 吉川優; 吉井達之; 青木一洋; 築地真也

  第15回バイオ関連化学シンポジウム, 08 Sep. 2021

  
• 近赤外蛍光タンパク質iRFPによる分裂酵母の細胞内タンパク質の可視化法の確立

  酒井啓一郎; 近藤洋平; 青木一洋; 後藤祐平

  酵母遺伝学フォーラム 第54 回 研究報告会, 01 Sep. 2021

  
• 分裂酵母 Schizosaccharomyces pombe のCDK 活性ライブイメージング

  杉山博紀; 後藤祐平; 青木一洋

  酵母遺伝学フォーラム 第54回研究報告会, 31 Aug. 2021

  
• 赤色光/遠赤色光応答性の 光遺伝学ツールPhyB-PIF系の線虫への応用

  青木 一洋; 佐藤-海老根映美; 小田茂和

  第73回日本細胞生物学会大会, 01 Jul. 2021

  
• アクトミオシン収縮力の光操作による細胞質分裂中の表層張力の機能解析

  山本啓; 三浦晴子; 近藤洋平; 青木一洋

  第73回日本細胞生物学会大会, 02 Jul. 2021

  
• Phycocyanobilin (PCB) functions as a brighter chromophore of iRFP than biliverdin.

  酒井 啓一郎; 近藤 洋平; 青木 一洋; 後藤 祐平

  第73回日本細胞生物学会大会, 02 Jul. 2021

  
• Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

  Kazuhiro Aoki

  European Light Microscopy Initiative 2021 (elmi2021), 23 Jun. 2021, Invited

  
• 光遺伝学を用いた細胞質分裂中の表層張力の機能解析

  青木 一洋

  発動分子科学研究会, 11 Jun. 2021, Invited

  
• 光遺伝学による細胞周期の制御

  青木 一洋

  新学術領域研究「生命金属科学」領域会議 第二回地方巡業, 04 Apr. 2021, Invited

  
• 光で生命の本質を探る

  青木 一洋

  第31回自然科学研究機構シンポジウム ― 生きているとは何か？ ―, 13 Mar. 2021

  
• Visualization and manipulation of cell signaling and cell fates.

  Kazuhiro Aoki

  Virtual Workshop: Cell State Transitions: Approaches, Experimental Systems and Models, 14 Dec. 2020, Invited

  
• 蛍光イメージングを用いた細胞内シグナル伝達系の可視化・定量化・操作

  青木一洋

  NCU Life Science Seminar, 16 Oct. 2020, Invited

  
• Linear regression analysis of seasonal change in medaka gonads.

  青木一洋; 四宮愛; 近藤洋平; 本田直樹; 吉村崇

  2020年度日本数理生物学会年会, 22 Sep. 2020, Invited

  
• Optogenetics for manipulating cellular functions

  Kazuhiro Aoki

  OIST seminar, 28 Feb. 2020, Invited

  
• Quantification and manipulation of cell signaling by live cell imaging

  Kazuhiro Aoki

  第42回日本分子生物学会年会, 05 Dec. 2019, Invited

  
• Optical control of cell signaling in human cells, fission yeast, and worms

  Kazuhiro Aoki

  ICSB2019, 02 Nov. 2019

  
• Optical Control of Cell Signaling by Genetically Encoded PhyB-PIF System

  Kazuhiro Aoki

  Resonance Bio International Symposium, 31 Oct. 2019

  
• Visualization and manipulation of cell signaling

  Kazuhiro Aoki

  The 2nd NIBB-Princeton Joint Symposium Imaging and Quantitative Biology, 28 Oct. 2019

  
• 細胞内シグナル伝達系の 可視化・定量化から見えてきた 分子夾雑の効果

  青木一洋

  新学術領域「分子夾雑の生命化学」第2回関東シンポジウム, 16 Oct. 2019, Invited

  
• 遺伝子技術と生細胞イメージングによる内在性分子濃度と解離定数の定量化

  青木一洋

  第60回日本組織細胞化学会総会・学術集会, 20 Sep. 2019, Invited

  
• Live cell imaging of cell-to-cell heterogeneity in JNK activation and stochastic cell death

  Kazuhiro Aoki

  第92回日本生化学会大会, 18 Sep. 2019, Invited

  
• 生細胞イメージングによる細胞内シグナル伝達系の可視化、定量化、操作

  青木一洋

  第9回光科学異分野横断萌芽研究会, 08 Aug. 2019, Invited

  
• 細胞内シグナル伝達系の 可視化、定量化、光操作

  青木一洋

  大阪大学蛋白質研究所セミナー がん研究の新機軸, 04 Jul. 2019, Invited

  
• Live-cell quantification of endogenous protein interactions by genome editing technique and fluorescence cross-correlation spectroscopy

  Kazuhiro Aoki; Komatsubara Akira; Yuhei Goto; Yohei Kondo

  第71回細胞生物学会年次大会, 25 Jun. 2019

  
• Visualization and manipulation of cell signaling

  Kazuhiro Aoki

  ExCELLS visit talks at Institute of Biological Chemistry, Academia Sinica, 21 Jun. 2019, Invited

  
• Live-cell quantification of the concentration and dissociation constant of endogenous proteins by a combination of CRISPR/Cas9 genome editing and FCS/FCCS.

  Kazuhiro Aoki

  Interface between Immunology & Quantitative Biology, 20 May 2019, Invited

  
• ERK活性の細胞間伝搬による細胞集団運動の制御

  青木一洋

  細胞外環境と老化研究のフロンティア, 02 Mar. 2019, Invited

  
• Optical Control of Cell Signaling by the Fully-Genetically Encoded PhyB-PIF System in Human Cells, Yeast and Worms

  Yoichi Uda; Shigekazu Oda; Yuhei Goto; Michiyuki Matsuda; Kazuhiro Aoki

  The 66th NIBB Conference / ABiS International Symposium "Cutting Edge Techniques of Bioimaging", 17 Feb. 2019

  
• 細胞集団運動と 非平衡輸送現象の接点

  青木一洋

  第九回定量生物学の会年会, 12 Jan. 2019, Invited

  
• Live-cell FRET imaging reveals propagating wave of ERK activation and its function in collective cell migration.

  Kazuhiro Aoki

  International Meeting on Optical Biosensors, 16 Nov. 2018

  
• Visualization, quantification, and manipulation of cell signaling with fluorescence live-cell imaging

  Kazuhiro Aoki

  Special seminar, 06 Nov. 2018, Jared E. Toettcher, Invited

  
• 細胞間のERK活性伝搬による 細胞集団運動の制御と光操作

  青木一洋

  「細胞を作る」研究会11.0, 18 Oct. 2018, Invited

  
• Toward quantitative understanding of intracellular signal transduction

  Kazuhiro Aoki

  第1回ExCELLSシンポジウム, 15 Oct. 2018

  
• 生細胞イメージングによる細胞内シグナル伝達系の可視化と光操作

  青木一洋

  第77回日本癌学会学術総会, 27 Sep. 2018, Invited

  
• 実験と数理モデルによる細胞内の情報処理機構の解析

  青木一洋

  第15回生物数学の理論とその応用 - 次世代の数理科学への展開 -, 12 Sep. 2018, Invited

  
• Live-cell imaging reveals intercellular propagating wave of ERK activation and its function in collective cell migration

  Kazuhiro Aoki

  Frontier Bioorganization Forum 2018, 09 Jul. 2018, Invited

  
• 細胞内シグナル伝達系の定量生物学

  青木一洋

  第32回腫瘍病理セミナー 金沢医科大学, 03 Jul. 2018, 清川悦子, Invited

  
• Visualization and optical manipulation of intracellular signaling.

  Kazuhiro Aoki

  第18回日本蛋白質科学会年会, 27 Jun. 2018, Invited

  
• Propagation wave of ERK activity orients collective cell migration

  Kazuhiro Aoki

  the 50th Annual Meeting of Japanese Society of Developmental Biologists, 12 May 2017, Invited

  
• ERK MAP キナーゼによる細胞増殖と集団細胞運動の制御

  青木 一洋

  生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム2017 “生命動態の分子メカニズムと数理”, 17 Mar. 2017, Invited

  
• Propagating wave of ERK activation orients collective cell migration

  Kazuhiro Aoki

  FIFTH ANNUAL WINTER Q-BIO MEETING, 21 Feb. 2017

  
• ERK活性の細胞間伝搬による細胞集団運動の制御

  青木 一洋

  第八回定量生物学の会年会, 09 Jan. 2017, 定量生物学の会

  
• Effects of cellular cytoplasm on kinetic reactions.

  Kazuhiro Aoki

  第39回日本分子生物学会年会, 30 Nov. 2016, 日本分子生物学会, Invited

  
• Intercellular propagation of ERK activity orients collective cell migration

  Kazuhiro Aoki

  第54回日本生物物理学会年会, 25 Nov. 2016, 日本生物物理学会, Invited

  
• ERK MAP kinase signaling under molecular crowding

  Kazuhiro Aoki

  The 9th Korea-Japan Seminar: Experiments and Simulations, 13 Nov. 2016, Invited

  
• 実験と数理・統計を組み合わせた癌研究

  青木 一洋

  第1回肺癌パｲｵｶﾝﾌｧﾚﾝｽ, 24 Sep. 2016, Invited

  
• 細胞内シグナル伝達系の可視化と光制御による細胞運命制御機構の定量的解析

  青木 一洋

  20 Sep. 2016, 新潟大学医歯学系分子細胞機能学・神経生化学（医学部生化学第二）, Invited

  
• Propagating wave of ERK activation orients collective cell migration

  Kazuhiro Aoki

  第68回日本細胞生物学会年会, 15 Jun. 2016, 日本細胞生物学会

  
• ERK activity propagation orients collective cell migration

  Kazuhiro Aoki

  Swiss-Kyoto Joint Symposium on Life Science 2016, 13 Jun. 2016, Invited

  
• ERK活性の細胞間伝搬による細胞集団運動の制御

  青木 一洋

  生命動態システム科学四拠点・CREST・PRESTO・QBiC 合同シンポジウム, 25 Mar. 2016, Invited

  
• Propagating wave of ERK activation orients collective cell migration Kazuhiro

  Kazuhiro Aoki

  Japan Q-Bio week, Force, Information & Dynamics, NIG Symposium 2016, 09 Jan. 2016, Japanese Society for Quantitative Biology

  
• 細胞内シグナル伝達系の細胞間伝搬による細胞集団運動の制御

  青木 一洋

  基生研研究会 物理学は生物現象の謎を解けるか, 05 Jan. 2016, Invited

  
• ERK活性の細胞間伝搬の定量解析

  青木 一洋

  第15回日本蛋白質科学会年会, 26 Jun. 2015, Invited

  
• Quantitative analysis of intracellular signal transduction with live cell imaging

  Kazuhiro Aoki

  OIST seminar, 27 May 2015, Invited

  
• Quantitative analysis of Ras-ERK signaling with live cell imaging

  Kazuhiro Aoki

  Frontier in Quantitative Biology seminar, 23 Apr. 2015, Invited

  
• Live-cell measurements of dissociation constants of signaling molecule compexes by fluorescence cross-correlation spectroscopy

  Kazuhiro Aoki

  第88回 日本薬理学会年会, 19 Mar. 2015, Invited

  
• FRETイメージングを用いた分子標的薬における癌細胞の内因的抗性の定量解析

  青木 一洋

  がん研セミナー, 09 Feb. 2015, Invited

  
• Quantitative analysis of ERK signaling with live cell imaging

  Kazuhiro Aoki

  2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling, 24 Jan. 2015, Invited

  
• THE 定量

  青木 一洋

  第7回 定量生物学の会 年会, 11 Jan. 2015, Invited

  
• KRas変異またはBRaf変異癌細胞における分子標的薬抵抗性のシステム解析

  青木 一洋

  第24回 日本循環薬理学会, 05 Dec. 2014, Invited

  
• FRETイメージングによるEGFシグナル伝達系のフィードフォワード・フィードバック経路の定量解析と分子標的薬感受性の予測

  青木 一洋

  第87回日本生化学会年会, 15 Oct. 2014, 日本生化学会, Invited

  
• イメージングによる癌遺伝子情報伝達系の定量解析

  青木 一洋

  第二回生体分子サイエンスセミナー, 06 Sep. 2014, 東京工業大学大学院 生命理工学研究科 生体分子機能工学専攻, Invited

  
• イメージングによる細胞内シグナル伝達系と分子標的薬抵抗性の定量解析

  青木 一洋

  第11回日本病理学会カンファレンス, 01 Aug. 2014, 日本病理学会, Invited

  
• Systems analysis of intracellular signaling by live cell imaging.

  Kazuhiro Aoki

  The Joint Annual Meeting of the Japanese Society for Mathematical Biology, 31 Jul. 2014, 日本数理生物学会, Invited

  
• In vivo dissociation constants measured by FCCS reveal a potential role in competitive bindings

  Kazuhiro Aoki

  The 37th Naito Conference, 15 Jul. 2014, 内藤記念財団, Invited

  
• FCCSによるin vivo Kdの定量法の開発

  青木 一洋

  第66回日本細胞生物学会, 13 Jun. 2014, 日本細胞生物学会, Invited

  
• Imaging and Mathematical Modeling of Molecular Activities in Living Cells

  Kazuhiro Aoki

  第12回JAFOEシンポジウム, 08 Jun. 2014, JAFOE, Invited

  
• Analysis of Multicellular Dynamics with Image Processing

  青木 一洋

  第47回日本発生生物学会年会, 27 May 2014, 日本発生生物学会, Invited

  
• イメージングによる細胞内シグナル伝達系の定量解析

  青木 一洋

  Research PlaNet 2014, 10 May 2014, アステラス株式会社, Invited

  
• Toward a Quantitative Simulation Model of Ras-ERK Signaling Pathway

  Kazuhiro Aoki

  The MAPK workshop, 07 Apr. 2014, Invited

  
• Stochastic ERK activation induced by noise and cell-cell propagation regulates cell density-dependent proliferation

  青木 一洋

  第87回日本薬理学会年会, 19 Mar. 2014, 日本薬理学会, Invited

  
• 分子標的薬抵抗性のシステム解析

  青木 一洋

  【がん支援活動】 冬期公開シンポジウム, 30 Jan. 2014, 新学術領域 がん研究分野の特性等を踏まえた支援活動, Invited

  
• Stochastic ERK activity pulses induced by intrinsic noise and cell-to-cell propagation regulate cell density-dependent proliferation.

  Kazuhiro Aoki

  第36回日本分子生物学会年会, 03 Dec. 2013, 日本分子生物学会, Invited

  
• ノイズと伝搬による確率的なERK 活性化と細胞増殖制御

  青木 一洋

  第六回定量生物学の会年会, 23 Nov. 2013, 定量生物学の会

  
• THE定量

  青木 一洋

  第六回定量生物学の会年会 チュートリアル, 22 Nov. 2013, 定量生物学の会

  
• Stochastic ERK activity pulses induced by noise and cell-to-cell propagation regulate cell density-dependent proliferation.

  Kazuhiro Aoki

  第51回日本生物物理学会年会, 28 Oct. 2013, 日本生物物理学会, Invited

  
• KRas遺伝子、またはBRaf遺伝子変異陽性がん細胞株の生細胞イメージングによるMEK阻害剤感受性のシステム解析

  青木 一洋

  第72回日本癌学会学術総会, 03 Oct. 2013, 日本癌学会

  
• FCCS、FRETイメージングによるRas-ERKシグナル伝達系の定量解析

  青木 一洋

  第五回「光塾」, 07 Sep. 2013, 光イメージング若手の会「光塾」, Invited

  
• 分子標的薬抵抗性のシステム解析

  青木 一洋

  がん若手研究者ワークショップ, 04 Sep. 2013, 新学術領域 がん研究分野の特性等を踏まえた支援活動

  
• Quantitative measurement of in vivo dissociation constant with fluorescence cross-correlation spectroscopy.

  Kazuhiro Aoki

  The 2nd HD Physiology International Symposium on Multi-Level Systems Biology, 28 Jun. 2013, 新学術領域研究「多階層生体機能学 HD Physiology」, Invited

  
• Role of stochastic ERK dynamics in cell proliferation.

  青木 一洋; 松田道行

  Systems Biology, 19 Jun. 2013, 日本細胞生物学会

  
• Toward a quantitative simulation model of Ras-ERK signaling pathway: Quantitative measurement with FCCS and FRET.

  Kazuhiro Aoki

  The 10th NIBB-EMBL Symposium "Quantitative Bioimaging", 17 Mar. 2013, National Institutie for Basic Biololgy, Invited

  
• Cell density-modulated ERK pulse frequency determines cell proliferation.

  Kazuhiro Aoki

  iCeMS One-Day Symposium on Theoretical and Computational Biology, 01 Mar. 2013, iCeMS, Invited

  
• Stochastic oscillation of ERK MAPK activity induced cell proliferation

  Kazuhiro Aoki

  2nd Japanese-French Cancer Workshop, 28 Nov. 2012, Invited

  
• FRETイメージングによる細胞内シグナル 伝達系の多細胞動態の可視化

  青木 一洋

  E Cell Workshop 2012, 26 Nov. 2012, Invited

  
• 定量したら生命システムが理解できるか？

  青木 一洋

  NGS現場の会・オープンバイオ研究会・生命情報科学若手の会・定量生物学の会 ４会合同シンポジウム 「これからの生命科学を考える」, 16 Oct. 2012, NGS現場の会・オープンバイオ研究会・生命情報科学若手の会・定量生物学の会, Invited

  
• 定量したら生命システムが理解できるか？

  青木 一洋

  NGS現場の会・オープンバイオ研究会・生命情報科学若手の会・定量生物学の会 ４会合同シンポジウム 「これからの生命科学を考える」, 16 Oct. 2012, NGS現場の会・オープンバイオ研究会・生命情報科学若手の会・定量生物学の会, Invited

  
• FRETイメージングとモデリングを用いたERKによる細胞増殖制御機構の解析

  青木一洋; 松田道行

  第71回日本癌学会学術総会, 20 Sep. 2012, 日本癌学会

  
• 力学場と化学場の測定・可視化と摂動技術の開発

  青木 一洋

  第1回多細胞動態研究のためのブレインストーミング・ワークショップ, 27 Jun. 2012, 多細胞動態研究イニシアティブ, Invited

  
• 細胞内情報伝達系の定量解析

  青木 一洋

  生命機能数理モデル検討会, 20 Jun. 2012, 大阪大学・生命機能数理モデル研究会, Invited

  
• FRET imaging revealed a functional link between frequency of ERK oscillation and cell growth control.

  Kazuhiro Aoki

  Joint symposium by JST/BBSRC (UK) Molecular Imaging and Systems Biology, 30 Jan. 2012, Invited

  
• 分子混み合いの反応速度論的展開と実証

  青木 一洋

  第四回定量生物の会年会, 10 Jan. 2012, 定量生物学の会, Invited

  
• 分子混み合いの影響を加味した 反応速度論モデルの導出と検証

  青木 一洋

  第1回「細胞環境の測定とモデリング」ワークショップ, 07 Nov. 2011, 第四回JSBi応用システムバイオロジー研究会, Invited

  
• 分子混み合いの影響を加味した 反応速度論モデルの導出と検証

  青木 一洋

  第1回「細胞環境の測定とモデリング」ワークショップ, 07 Nov. 2011, 第四回JSBi応用システムバイオロジー研究会, Invited

  
• FRETイメージング によるERK活性の細胞増殖制御機構の定量解析

  青木一洋; 松田道行

  第84回日本生化学会大会, 21 Sep. 2011, 日本生化学会, Invited

  
• 実測パラメーターに基づく細胞内シグナル伝達系の定量的シミュレーション

  青木 一洋

  第６回トランスポーター研究会, 11 Jun. 2011, トランスポーター研究会, Invited

  
• 定量的な細胞シグナル伝達モデルの構築にむけて

  青木 一洋

  細胞システムの動態と論理, 31 Mar. 2011, Invited

  
• がんの制御に向けたシステム的なアプローチ

  青木 一洋

  公開シンポジウム 「日本のライフ研究開発を元気にする“夢”と“攻め” 〜バイオ研究と計算・情報科学の次世代型融合を探る〜」, 22 Jan. 2011, 神戸医療産業都市構想研究会, Invited

  
• Quantitative kinetic analysis reveals processive phosphorylation of ERK MAP kinase in mammalian cells.

  Kazuhiro Aoki

  BMB 2010, 07 Dec. 2010, Invited

  
• アクトミオシン収縮力の光操作技術の開発と応用

  山本啓; 三浦晴子; 近藤洋平; 青木一洋

  第6回CRESTオプトバイオ領域会議, 23 Dec. 2021

  
• ERK 活性伝搬による細胞集団運動の制御

  青木 一洋

  東京大学 医科学研究所 共同研究拠点事業 平成27 年度 若手シンポジウム 若手研究者が拓く医科学研究の道, Invited

  

Books and Other Publications

• 生体の科学 特集 生物物理学の進歩——生命現象の定量的理解へ向けて

  青木一洋, Editor

  医学書院, Jun. 2021, Not refereed

  
• 定量生物学 (DOJIN BIOSCIENCE SERIES)

  小林 徹也, Contributor

  化学同人, Aug. 2018, Not refereed

  Find Kyoto University's collection of books :

  
• バイオ画像解析手とり足とりガイド : バイオイメージングデータを定量して生命の形態や動態を理解する!

  小林, 徹也; 青木, 一洋

  羊土社, Dec. 2014

  Find Kyoto University's collection of books :

  

Industrial Property Rights

• 特開2017-165688, 特願2016-053156, NRG1の切断検出用プローブ、NRG1の切断検出用プローブをコードするポリヌクレオチド、NRG1の切断検出用プローブの発現ベクター、NRG1の切断検出用形質転換体、NRG1の切断検出方法、およびNRG1切断酵素の阻害剤のスクリーニング方法

  瀬原 淳子; 亀崎 青沙; 佐藤 文規; 青木 一洋; 川上 浩一

  
• WO2015-182625, JP2015065150, Ras活性阻害薬及びその用途

  松田 道行; 齋藤 勝広; 大石 真也; 小松 直貴; 青木 一洋; 李 春杰

  
• 特許第5802674号, 特願2012-536438, 蛍光共鳴エネルギー移動の原理に基づく一分子型FRETバイオセンサーのリンカー

  松田 道行; 小松 直貴; 青木 一洋; 上岡 裕治; 幸長 弘子; 稲岡 芳恵; 櫻井 敦朗; 清川 悦子; 隅山 健太

  
• WO2012-043477, JP2011071891, 蛍光共鳴エネルギー移動の原理に基づく一分子型FRETバイオセンサーのリンカー

  松田 道行; 小松 直貴; 青木 一洋; 上岡 裕治; 幸長 弘子; 稲岡 芳恵; 櫻井 敦朗; 清川 悦子; 隅山 健太

  

Awards

• 20 Jun. 2013

  若手最優秀発表賞（日本細胞生物学会）
• 07 Sep. 2013

  がん若手研究者ワークショップ最優秀演者賞（新学術領域「がん支援」若手支援委員会）
• 15 Apr. 2015

  科学技術分野の文部科学大臣表彰 若手科学者賞

External funds: Kakenhi

• Gating mechanism of ERK and AKT in cell cycle checkpoint

  Grant-in-Aid for Scientific Research (B)

  Basic Section 44010:Cell biology-related

  National Institutes of Natural Sciences

  青木 一洋

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ERK;Akt;細胞周期;イメージング;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02625/
• 多細胞動態を司る支配方程式のデータ駆動的解読

  Grant-in-Aid for Scientific Research (B)

  Basic Section 62010:Life, health and medical informatics-related

  Hiroshima University

  本田 直樹

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  データ駆動生物学;数理モデリング;機械学習;数理モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03541/
• Understanding of cell signaling with information physics

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  National Institutes of Natural Sciences

  青木 一洋

  From 28 Jun. 2019, To 31 Mar. 2024, Granted

  情報理論;細胞内情報伝達;FRETイメージング;1分子イメージング;EGF;EGFR;ERK;情報量;１分子イメージング;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19H05798/
• Information physics of living matters

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  The University of Tokyo

  岡田 康志

  From 28 Jun. 2019, To 31 Mar. 2024, Granted

  情報物理学;生物物理学;非平衡統計力学;情報熱力学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-19H05794/
• Development of optogenetic tools for manipulation of cellular function by genetically encoded PhyB-PIF system

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Center for Novel Science Initatives, National Institutes of Natural Sciences

  青木 一洋

  From 01 Apr. 2018, To 31 Mar. 2020, Discontinued

  光遺伝学;optogenetics;Phytochrome;ERK;PhyB;PIF;線虫;分裂酵母;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04754/
• Quantitative understanding of the mechanism of G1-S phase checkpoint regulated by ERK signal

  Grant-in-Aid for Scientific Research (B)

  Basic Section 44010:Cell biology-related

  Center for Novel Science Initatives, National Institutes of Natural Sciences

  Kazuhiro AOKI

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  ERK;Akt;光遺伝学;細胞周期;チェックポイント;RB;FRET;G1-S期チェックポイント;イメージング;G1/S;サイクリン;CDK

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02444/
• 癌細胞の脆弱性と頑強性の構成的理解

  Grant-in-Aid for Scientific Research (B)

  Center for Novel Science Initatives, National Institutes of Natural Sciences;Okazaki Research Facilities, National Institutes of Natural Sciences

  青木 一洋

  From 19 Jul. 2016, To 31 Mar. 2020, Discontinued

  oncogene addiction;KRas;BRaf;ERK;intrinsic resistance;Oncogene addiction;Intrinsic resistance;Ras;遺伝子編集

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16KT0069/
• ERK活性伝播による３次元形態形成制御の構成的理解

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Okazaki Research Facilities, National Institutes of Natural Sciences

  青木 一洋

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ERK;細胞集団運動;collective migration;FRET;集団運動;細胞間伝搬;シグナル伝達;光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01447/
• 遺伝子にコードされたPhyB-PIF系を用いた細胞機能の光制御技術の開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Okazaki Research Facilities, National Institutes of Natural Sciences

  青木 一洋

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  光遺伝学;Phytochrome;ERK;シグナル伝達;PIF;Optogenetics;PhyB

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01425/
• Systems analysis of intrinsic resistance to MEK inhibitor in KRas- or BRaf-mutataed cancer cells

  Grant-in-Aid for Scientific Research (B)

  Okazaki Research Facilities, National Institutes of Natural Sciences;Kyoto University

  Kazuhiro AOKI

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  内因的抵抗性;FRETイメージング;数理モデル;シミュレーション;KRas;BRaf;ERK;PI3K;FRET;Akt;イメージング;レポーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26290053/
• 反応速度論的パラメーター測定のためのイメージング基盤技術構築

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  青木 一洋

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  FCS;FCCS;解離定数;定量;FRET;レンチウイルス;レトロウイルス;組換え

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25136706/
• ERK経路の多細胞動態と細胞増殖制御の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  青木 一洋

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  FRETイメージング;シミュレーション;ERK;オプトジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25117715/
• Systematic analysis of Ras/ERK pathway with FRET imaging

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kazuhiro AOKI

  From 28 Apr. 2011, To 31 Mar. 2015, Project Closed

  FRETイメージング;分子標的薬;Ras;ERK;PI3K;mTOR;シミュレーション;FRET;Akt;フィードバック;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701052/
• 生体イメージングによる反応速度論的パラメーターの高感度計測

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  青木 一洋

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  FRET;FCCS;パラメーター;シミュレーション;解離定数

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23136504/
• Multidimendional FRET imaging of intracellular signal transduction

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Michiyuki Matsuda

  From 01 Apr. 2010, To 31 Mar. 2016, Project Closed

  がん;二光子イメージング;フレットイメージング;蛍光タンパク質;バイオセンサー;FRETイメージング;FRET;蛍光共鳴エネルギー移動;生体イメージング;蛍光イメージング;神経発生;トランスジェニックマウス;Rac1;二光子顕微鏡;FRETバイオセンサー;Cdc42;MDCK細胞;脳腫瘍

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22113002/
• Analysis of mechanisms of ERK MAP kinase phosphorylation

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kazuhiro AOKI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  FRET;イメージング;シグナル伝達;システム生物学;癌;ERK;シミュレーション;リン酸化;パラメーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790273/
• Mathematical study for homeostasis in living systems based on network structure

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43040:Biophysics-related

  Kyoto University

  Atsushi Mochizuki

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  反応ネットワーク;制御ネットワーク;数理理論;構造感度解析;構造分岐解析;細胞周期;恒常性;ネットワーク;感度解析;分岐解析;チェックポイント制御;ダイナミクス;数理解析;構造理論;数理生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03196/
• Mechanisms of cancer cell elimination by remodeling of cell adhesion molecules

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  青木 一洋

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  細胞競合;ERK;ZO-1;タイトジャンクション

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01416/
• Gating mechanism of ERK and AKT in cell cycle checkpoint

  Grant-in-Aid for Scientific Research (B)

  Basic Section 44010:Cell biology-related

  Kyoto University;National Institutes of Natural Sciences

  青木 一洋

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ERK;AKT;細胞周期;イメージング;Akt;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23888/
• Data-driven identification of governing equations for multicellular dynamics

  Grant-in-Aid for Scientific Research (B)

  Basic Section 62010:Life, health and medical informatics-related

  Hiroshima University

  本田 直樹

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  データ駆動生物学;数理モデリング;機械学習;数理モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21716/
• Advanced Bioimaging Support

  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)

  National Institute for Physiological Sciences

  鍋倉 淳一

  From 01 Apr. 2022, To 31 Mar. 2028, Granted

  バイオイメージング;光学顕微鏡支援;電子顕微鏡支援;磁気共鳴画像支援;画像解析支援;トレーニング;科研費課題;Global BioImaging (GBI)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04926/
• 成長因子バイオセンサーの開発と生体内での成長因子の可視化

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  National Institutes of Natural Sciences

  青木 一洋

  From 28 Jun. 2024, To 31 Mar. 2027, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21981/
• 成長因子バイオセンサーの開発と生体内での成長因子の可視化

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  青木 一洋

  From 28 Jun. 2024, To 31 Mar. 2027, Granted

  成長因子;蛍光バイオセンサー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21981/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biology and Life Science

  N484, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Mathematical, Statistical and Computational Biology for Expe rimental Biologists

  M344, Year-long, Institute for Liberal Arts and Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Mathematical, Statistical and Computational Biology for Experimental Biologists

  1034, Year-long, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Studies on Signal Transduction

  1029, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Chromosome Researches

  1027, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Beginning Science

  1025, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Study CourseII(Biological Sciences) 21

  8724, Year-long, Faculty of Science, 12
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory work in Biological Science C

  3764, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Cell Biology II

  2718, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Cell Biology I

  2717, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5

Participation in PhD Defense

• 数理モデリングを用いた予測符号化に基づく免疫記憶形成によって実現される抗原の有害/無害識別メカニズムの解明

  YOSHIDO KANA, Graduate School of Biostudies, Sub-chief Examiner

  25 Mar. 2024
• バーンズ迷路における空間スケールがマウスの空間学習に与える影響

  TACHIKI YUTO, Graduate School of Biostudies, Sub-chief Examiner

  25 Mar. 2024

Administration

Faculty management (title, position)

• From 01 Apr. 2024

  生命動態共用研究施設運営委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  ダイバーシティ推進委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  同窓会 副会長
• From 01 Apr. 2024, To 31 Mar. 2025

  改善委員会
• From 01 Nov. 2023

  将来像検討委員会
• From 01 Apr. 2024

  教務委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  統合生命科学副専攻長

Academic, Social Contribution

Committee Memberships

• From Jun. 2024, To Jun. 2026

  理事、庶務幹事, 日本細胞生物学会
• From Jun. 2018, To Jun. 2022

  理事, 日本細胞生物学会
• From Apr. 2024, To Mar. 2029

  アドバイザー, JST ACT-X「生命と情報」
• From Apr. 2022, To Feb. 2027

  アドバイザー, JST CREST「多細胞」
• From Oct. 2023, To Sep. 2025

  アドバイザー, JST 創発「岡田パネル」

Social Contribution

• 進路講演会

  Lecturer

  岡崎北高校, 進路講演会, From 11 Dec. 2023, To 11 Dec. 2023

  
• ニコニコ生放送「生命の基本単位『細胞』を見て、感じて、操作しよう！」

  Guest

  niconico, ニコニコ生放送, From 17 Nov. 2023, To 18 Nov. 2023

  
• EGAO FRIDAY SCIENCE LAB

  Guest

  エフエムEGAO, EGAO FRIDAY SCIENCE LAB, From 04 Aug. 2023, To 04 Aug. 2023

  
• 光で生命の本質に迫る

  Guest, Panelist

  大学共同利用機関法人自然科学研究機構, 第31回自然科学研究機構シンポジウム, From 13 Mar. 2021, To 13 Mar. 2021