Basic Information

Affiliated programs (koza)

• Graduate School of Science, 生物科学専攻 霊長類学講座, 教授

Email Address

• Email Address

  akari.hirofumi.5zkyoto-u.ac.jp

Professional Memberships

• 実験動物学会
• 獣医学会
• エイズ学会
• ウイルス学会
• 日本HTLV-1学会

Academic Degree

• 農学修士(鹿児島大学)
• 博士（獣医学）(山口大学)

Academic Resume (Graduate Schools)

• 鹿児島大学, 大学院農学研究科獣医学専攻, 修了
• 山口大学, 大学院連合獣医学研究科獣医学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 鹿児島大学, 農学部獣医学科, 卒業

High School

• High School

  大阪府立池田高等学校

Research History

• From Apr. 2022, To Present

  Kyoto University, Center for the Evolutionary Origins of Human Behavior, Professor
• From 2009, To Mar. 2022

  Primate Research Institute, Kyoto University, Professor
• From 2005, To 2008

  National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba Primate Researh Center, Laboratory chief
• From 2002, To 2004

  国立感染症研究所 主任研究官
• From 1999, To 2001

  NIH, NIAID (USA) Research Fellow
• From 1997, To 2001

  The University of Tokushima, Faculty of Medicine
• From 1994, To 1996

  National Institute of Infectious Diseases, Tsukuba Primate Research Center, Post-doctoral scientist

Language of Instruction

• English

ID,URL

• J-Global ID

  200901077135246434

• External link

  https://akari-labo.jimdo.com/

Website(s) (URL(s))

• http://akari-labo.jimdo.com/

researchmap URL

• https://researchmap.jp/08050230904

Research

Research Topics, Overview of the research

• Research Topics

  Basic and applied research on intractable viral diseases using nonhuman primate models

• Overview of the research

  I elucidate the mechanisms of the pathogenesis and the persistence of intractable viral infections in the hosts and the immune responses against them, and also promote applied research such as the development of new therapies and vaccines.

Research Interests

• 感染症
• モデル動物
• ウイルス
• virology

Research Areas

• Life sciences, Immunology
• Life sciences, Virology
• Life sciences, Laboratory animal science

Papers

• Highly homologous simian T-cell leukemia virus type 1 genome in Japanese macaques: a large cohort study

  Kou Hiraga; Tomoya Kitamura; Madoka Kuramitsu; Megumi Murata; Kenta Tezuka; Kazu Okuma; Isao Hamaguchi; Hirofumi Akari; Takuo Mizukami

  Virology Journal, 30 Jul. 2024

  
• 短期培養した自家PBMCを抗原とする新規抗ATL免疫療法の前臨床検討(Preclinical evidence for an anti-ATL immunotherapy using short-term cultured autologous PBMC as a vaccine)

  神奈木 真理; 長谷川 温彦; 村田 めぐみ; 中嶋 伸介; 佐竹 敦志; 伊藤 量基; 宇都宮 與; 藤澤 順一; 大隈 和; 明里 宏文

  日本癌学会総会記事, Sep. 2023

  
• Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses.

  Takafumi Shichijo; Jun-Ichirou Yasunaga; Kei Sato; Kisato Nosaka; Kosuke Toyoda; Miho Watanabe; Wenyi Zhang; Yoshio Koyanagi; Edward L Murphy; Roberta L Bruhn; Ki-Ryang Koh; Hirofumi Akari; Terumasa Ikeda; Reuben S Harris; Patrick L Green; Masao Matsuoka

  Proceedings of the National Academy of Sciences of the United States of America, 26 Mar. 2024

  
• Production and Purification of Cell Culture–generated Hepatitis B Virus by Transient Transfection and Density Gradient

  Asako Murayama; Hirofumi Akari; Takanobu Kato

  BIO-PROTOCOL, Jul. 2023, Peer-reviewed, Invited

  
• Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation

  Jumpei Maki; Yusuke Hanaki; Ryo C Yanagita; Masayuki Kikumori; Anastasiia Kovba; Ayaka Washizaki; Chihiro Tsukano; Hirofumi Akari; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry, 08 Sep. 2023, Peer-reviewed

  
• Annual two-dose tetanus toxoid vaccination induces protective humoral immunity to all age groups of rhesus macaques.

  Megumi Murata; Anastasiia Kovba; Akihisa Kaneko; Mayumi Morimoto; Akiyo Ishigami; Takayoshi Natsume; Ayaka Washizaki; Takako Miyabe-Nishiwaki; Juri Suzuki; Hirofumi Akari

  Experimental animals, 06 Jun. 2023, Peer-reviewed, Last author, Corresponding author

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• Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses.

  Atsuhiko Hasegawa; Megumi Murata; Tomoka Fujikawa; Kuniko Katagiri; Yoshiko Nagano; Takao Masuda; Madoka Kuramitsu; Shinsuke Nakajima; Jun-Ichi Fujisawa; Kazu Okuma; Poonam Grover; Maureen Kidiga; Hirofumi Akari; Mari Kannagi

  PLoS pathogens, 02 Feb. 2023, Peer-reviewed

  
• Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques

  Hirotaka Ode; Akatsuki Saito; Ayaka Washizaki; Yohei Seki; Takeshi Yoshida; Shigeyoshi Harada; Hiroshi Ishii; Tatsuo Shioda; Yasuhiro Yasutomi; Tetsuro Matano; Tomoyuki Miura; Hirofumi Akari; Yasumasa Iwatani

  Journal of General Virology, 07 Oct. 2022, Peer-reviewed, Corresponding author

  
• Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

  Ayaka Washizaki; Asako Murayama; Megumi Murata; Tomoko Kiyohara; Keigo Yato; Norie Yamada; Hussein Hassan Aly; Tomohisa Tanaka; Kohji Moriishi; Hironori Nishitsuji; Kunitada Shimotohno; Yasumasa Goh; Ken J. Ishii; Hiroshi Yotsuyanagi; Masamichi Muramatsu; Koji Ishii; Yoshimasa Takahashi; Ryosuke Suzuki; Hirofumi Akari; Takanobu Kato

  Nature Communications, 05 Sep. 2022, Peer-reviewed, Corresponding author

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• A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening

  Hirotaka Sato; Tomoyuki Murakami; Ryosuke Matsuura; Masako Abe; Seiji Matsuoka; Yoko Yashiroda; Minoru Yoshida; Hirofumi Akari; Yosuke Nagasawa; Masami Takei; Yoko Aida

  Viruses, 16 Jun. 2022, Peer-reviewed

  
• CD163陽性細胞は高病原性SHIV感染サルの治療下におけるウイルスRNA陽性細胞である

  渡部 祐司; 岩見 真吾; 松浦 嘉奈子; 森 ひろみ; 日紫喜 隆行; 三浦 智行; 明里 宏文; 五十嵐 樹彦

  日本エイズ学会誌, Nov. 2015

  
• サルレトロウイルス4型によるニホンザル血小板減少症

  岡本 宗裕; 宮沢 孝幸; 吉川 禄助; 鈴木 樹理; 宮部 貴子; 佐藤 英次; 吉田 友教; 森本 真弓; 兼子 明久; 前田 典彦; 橋本 直子; 明里 宏文

  霊長類研究 Supplement, 2015

  
• The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation

  Ayaka Washizaki; Megumi Murata; Yohei Seki; Masayuki Kikumori; Yinpui Tang; Weikeat Tan; Nadita P. Wardani; Kazuhiro Irie; Hirofumi Akari

  Viruses, 09 Oct. 2021, Peer-reviewed, Last author, Corresponding author

  
• Prevalence of antibodies against human respiratory viruses potentially involving anthropozoonoses in wild bonobos.

  Tomoyuki Yoshida; Hiroyuki Takemoto; Tetsuya Sakamaki; Nahoko Tokuyama; John Hart; Terese Hart; Jef Dupain; Amy Cobden; Mbangi Mulavwa; Chie Hashimoto; Mina Isaji; Akihisa Kaneko; Yuki Enomoto; Eiji Sato; Takanori Kooriyama; Takako Miyabe-Nishiwaki; Juri Suzuki; Akatsuki Saito; Takeshi Furuichi; Hirofumi Akari

  Primates; journal of primatology, 02 Aug. 2021, Peer-reviewed, Last author, Corresponding author

  
• Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease.

  Yoshihiro Iwamoto; Yohei Seki; Kahoru Taya; Masahiro Tanaka; Shoichi Iriguchi; Yasuyuki Miyake; Emi E Nakayama; Tomoyuki Miura; Tatsuo Shioda; Hirofumi Akari; Akifumi Takaori-Kondo; Shin Kaneko

  Molecular therapy. Methods & clinical development, 11 Jun. 2021, Peer-reviewed

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• In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions.

  Mikiko Izaki; Jun-Ichirou Yasunaga; Kisato Nosaka; Kenji Sugata; Hayato Utsunomiya; Youko Suehiro; Takafumi Shichijo; Asami Yamada; Yasuhiko Sugawara; Taizo Hibi; Yukihiro Inomata; Hirofumi Akari; Anat Melamed; Charles Bangham; Masao Matsuoka

  PLoS pathogens, Feb. 2021, Peer-reviewed

  
• A Potent anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Rhesus Macaques.

  Saori Matsuoka; Takeo Kuwata; Hiroshi Ishii; Tsuyoshi Sekizuka; Makoto Kuroda; Masato Sano; Midori Okazaki; Hiroyuki Yamamoto; Mikiko Shimizu; Shuzo Matsushita; Yohei Seki; Akatsuki Saito; Hiromi Sakawaki; Vanessa M Hirsch; Tomoyuki Miura; Hirofumi Akari; Tetsuro Matano

  Journal of virology, 13 Jan. 2021, Peer-reviewed

  
• Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques.

  Megumi Murata; Jun-Ichirou Yasunaga; Ayaka Washizaki; Yohei Seki; Madoka Kuramitsu; Wei Keat Tan; Anna Hu; Kazu Okuma; Isao Hamaguchi; Takuo Mizukami; Masao Matsuoka; Hirofumi Akari

  Retrovirology, 23 Jun. 2020, Peer-reviewed, Last author, Corresponding author

  
• Hematological and blood chemistry values in captive Japanese macaques (Macaca fuscata fuscata).

  Takako Miyabe-Nishiwaki; Andrew J J MacIntosh; Akihisa Kaneko; Mayumi Morimoto; Juri Suzuki; Hirofumi Akari; Munehiro Okamoto

  Journal of medical primatology, Dec. 2019, Peer-reviewed

  
• 【HIV感染症の根治を目指して】HIV感染症の根治を目指して 非ヒト霊長類モデルを用いた取り組み

  関 洋平; 明里 宏文

  日本エイズ学会誌, Aug. 2019, Peer-reviewed, Last author, Corresponding author

  
• PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

  Kei Miyakawa; Satoko Matsunaga; Masaru Yokoyama; Masako Nomaguchi; Yayoi Kimura; Mayuko Nishi; Hirokazu Kimura; Hironori Sato; Hisashi Hirano; Tomohiko Tamura; Hirofumi Akari; Tomoyuki Miura; Akio Adachi; Tatsuya Sawasaki; Naoki Yamamoto; Akihide Ryo

  Nature communications, 23 Apr. 2019, Peer-reviewed

  
• HTLV-1感染におけるT細胞免疫抑制の霊長類モデルとしてのSTLV-1自然感染ニホンザル(Impaired T-cell responses in natural infection of STLV-1 as a primate model of immune suppression in HTLV-1 infection)

  長谷川 温彦; 冨士川 朋夏; Ganbaatar Undrakh; 永野 佳子; 増田 貴夫; 田中 勇悦; 明里 宏文; 神奈木 真理

  日本癌学会総会記事, Sep. 2018

  
• Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model.

  Hiroshi Yokokawa; Atsunori Higashino; Saori Suzuki; Masaki Moriyama; Noriko Nakamura; Tomohiko Suzuki; Ryosuke Suzuki; Koji Ishii; Kouji Kobiyama; Ken J Ishii; Takaji Wakita; Hirofumi Akari; Takanobu Kato

  Gut, Feb. 2018, Peer-reviewed, Corresponding author

  
• Understanding the facts and minding the gap of (HIV-1/HIV-2) primate research and infectious disease laboratories in Africa

  Ejikeugwu C; Eze P; Iroha I; Esimone C; Adikwu M; Akari H

  International Journal of Virology and AIDS, 2018, Peer-reviewed, Last author, Corresponding author

  
• Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates.

  Taeko K Naruse; Hirofumi Akari; Tetsuro Matano; Akinori Kimura

  Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2018, Peer-reviewed

  
• 新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである

  鷲崎 彩夏; 村田 めぐみ; 関 洋平; Tang Yin Pui; 寒川 裕之; 入江 一浩; 明里 宏文

  日本エイズ学会誌, Nov. 2017

  
• Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

  Rie Furuta; Jun-Ichirou Yasunaga; Michi Miura; Kenji Sugata; Akatsuki Saito; Hirofumi Akari; Takaharu Ueno; Norihiro Takenouchi; Jun-Ichi Fujisawa; Ki-Ryang Koh; Yusuke Higuchi; Mohamed Mahgoub; Masakazu Shimizu; Fumihiko Matsuda; Anat Melamed; Charles R Bangham; Masao Matsuoka

  PLoS pathogens, Nov. 2017, Peer-reviewed

  
• Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif.

  Masaaki Nakashima; Shinya Tsuzuki; Hiroaki Awazu; Akiko Hamano; Ayaka Okada; Hirotaka Ode; Masami Maejima; Atsuko Hachiya; Yoshiyuki Yokomaku; Nobuhisa Watanabe; Hirofumi Akari; Yasumasa Iwatani

  Journal of molecular biology, 21 Apr. 2017, Peer-reviewed

  
• Hematopoietic Stem Cell Infected with HTLV-1 Functions As a Viral Reservoir In Vivo

  Jun-ichirou Yasunaga; Rie Furuta; Michi Miura; Kenji Sugata; Akatsuki Saito; Akari Hirofumi; Takaharu Ueno; Norihiro Takenouchi; Jun-ichi Fujisawa; Masakazu Shimizu; Fumihiko Matsuda; Anat Melamed; Charles R. M. Bangham; Masao Matsuoka

  BLOOD, Dec. 2016, Peer-reviewed

  
• Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

  Kenji Sugata; Jun-Ichirou Yasunaga; Michi Miura; Hirofumi Akari; Atae Utsunomiya; Kisato Nosaka; Yuko Watanabe; Hitoshi Suzushima; Ki-Ryang Koh; Masanori Nakagawa; Michinori Kohara; Masao Matsuoka

  Scientific reports, 02 Jun. 2016, Peer-reviewed

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• Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to Cynomolgus macaque Trimcyp generated by random mutagenesis

  Tahmina Sultana; Emi E. Nakayama; Satoshi Tobita; Masaru Yokoyama; Yohei Seki; Akatsuki Saito; Masako Nomaguchi; Akio Adachi; Hirofumi Akari; Hironori Sato; Tatsuo Shioda

  Journal of General Virology, 01 Apr. 2016, Peer-reviewed

  
• Epidemiological Surveillance of Lymphocryptovirus Infection in Wild Bonobos.

  Tomoyuki Yoshida; Hiroyuki Takemoto; Tetsuya Sakamaki; Nahoko Tokuyama; John Hart; Terese Hart; Jef Dupain; Amy Cobden; Mbangi Mulavwa; Yoshi Kawamoto; Akihisa Kaneko; Yuki Enomoto; Eiji Sato; Takanori Kooriyama; Takako Miyabe-Nishiwaki; Juri Suzuki; Akatsuki Saito; Munehiro Okamoto; Masaki Tomonaga; Tetsuro Matsuzawa; Takeshi Furuichi; Hirofumi Akari

  Frontiers in microbiology, 2016, Peer-reviewed, Last author, Corresponding author

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• Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey.

  Saori Suzuki; Ken-Ichi Mori; Atsunori Higashino; Yuki Iwasaki; Yasuhiro Yasutomi; Noboru Maki; Hirofumi Akari

  Microbiology and immunology, Jan. 2016, Peer-reviewed

  
• Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers.

  Takushi Nomura; Hiroyuki Yamamoto; Hiroshi Ishii; Hirofumi Akari; Taeko K Naruse; Akinori Kimura; Tetsuro Matano

  PLoS Pathog., Nov. 2015, Peer-reviewed

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• Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

  Munehiro Okamoto; Takayuki Miyazawa; Shigeru Morikawa; Fumiko Ono; Shota Nakamura; Eiji Sato; Tomoyuki Yoshida; Rokusuke Yoshikawa; Kouji Sakai; Tetsuya Mizutani; Noriyo Nagata; Jun-ichiro Takano; Sachi Okabayashi; Masataka Hamano; Koji Fujimoto; Takaaki Nakaya; Tetsuya Iida; Toshihiro Horii; Takako Miyabe-Nishiwaki; Akino Watanabe; Akihisa Kaneko; Akatsuki Saito; Atsushi Matsui; Toshiyuki Hayakawa; Juri Suzuki; Hirofumi Akari; Tetsuro Matsuzawa; Hirohisa Hirai

  Scientific reports, 06 Mar. 2015, Peer-reviewed

  
• TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

  Guangyong Ma; Jun-ichirou Yasunaga; Hirofumi Akari; Masao Matsuoka

  Proceedings of the National Academy of Sciences of the United States of America, 17 Feb. 2015, Peer-reviewed

  
• Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers.

  Takushi Nomura; Hiroyuki Yamamoto; Hiroshi Ishii; Hirofumi Akari; Taeko K Naruse; Akinori Kimura; Tetsuro Matano

  PLoS pathogens, 2015, Peer-reviewed

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• Role of accessory proteins in primate immunopathogenesis

  Yoshida T; Akari H

  Journal of AIDS Research, 2015, Peer-reviewed

  
• 再生医療技術のエイズ研究応用のためのアカゲザルiPS 細胞樹立と CD34 陽性 細胞への分化

  田谷 かほる; 武田 英里; 中山 英美; 塩田 達雄; 明里 宏文; 金子 新

  Dec. 2014, Peer-reviewed

  
• Seroprevalence of Japanese encephalitis virus infection in captive Japanese macaques (Macaca fuscata).

  Hiroshi Shimoda; Akatsuki Saito; Keita Noguchi; Yutaka Terada; Ryusei Kuwata; Hirofumi Akari; Tomohiko Takasaki; Ken Maeda

  Primates; journal of primatology, Jul. 2014, Peer-reviewed

  
• Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques.

  Taeko K Naruse; Hirofumi Akari; Tetsuro Matano; Akinori Kimura

  Immunogenetics, Mar. 2014, Peer-reviewed

  
• Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans

  Meng Ling Moi; Tomohiko Takasaki; Tsutomu Omatsu; Shinichiro Nakamura; Yuko Katakai; Yasushi Ami; Yuriko Suzaki; Masayuki Saijo; Hirofumi Akari; Ichiro Kurane

  JOURNAL OF GENERAL VIROLOGY, Mar. 2014, Peer-reviewed

  
• Diversity of antiretroviral host factor TRIM5 gene in macaque monkeys: genetic information for establishment of HIV-1 primate model

  Saito A; Kono K; Kawamoto Y; Higashino A; Suzuki S; Yoshida T; Torii R; Yasutomi Y; Shioda T; E Nakayama EE; Akari H

  The journal of AIDS research, 2014, Invited

  
• New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood.

  Yasumitsu Fujie; Noemi Fusaki; Tomohiko Katayama; Makoto Hamasaki; Yumi Soejima; Minami Soga; Hiroshi Ban; Mamoru Hasegawa; Satoshi Yamashita; Shigemi Kimura; Saori Suzuki; Tetsuro Matsuzawa; Hirofumi Akari; Takumi Era

  PloS one, 2014, Peer-reviewed

  
• Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.

  Masako Nomaguchi; Masaru Yokoyama; Ken Kono; Emi E Nakayama; Tatsuo Shioda; Naoya Doi; Sachi Fujiwara; Akatsuki Saito; Hirofumi Akari; Kei Miyakawa; Akihide Ryo; Hirotaka Ode; Yasumasa Iwatani; Tomoyuki Miura; Tatsuhiko Igarashi; Hironori Sato; Akio Adachi

  Journal of virology, Nov. 2013, Peer-reviewed

  
• Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection

  Michi Miura; Jun-ichiro Yasunaga; Junko Tanabe; Kenji Sugata; Tiejun Zhao; Guangyong Ma; Paola Miyazato; Koichi Ohshima; Akihisa Kaneko; Akino Watanabe; Akatsuki Saito; Hirofumi Akari; Masao Matsuoka

  RETROVIROLOGY, Oct. 2013, Peer-reviewed

  
• Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration

  Tomoyuki Yoshida; Saori Suzuki; Yuki Iwasaki; Akihisa Kaneko; Akatsuki Saito; Yuki Enomoto; Atsunori Higashino; Akino Watanabe; Juri Suzuki; Kenichi Inoue; Teiko Kuroda; Masahiko Takada; Ryoji Ito; Mamoru Ito; Hirofumi Akari

  IMMUNOLOGY LETTERS, Jul. 2013, Peer-reviewed

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• TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1

  Akatsuki Saito; Masako Nomaguchi; Ken Kono; Yasumasa Iwatani; Masaru Yokoyama; Yasuhiro Yasutomi; Hironori Sato; Tatsuo Shioda; Wataru Sugiura; Tetsuro Matano; Akio Adachi; Emi E. Nakayama; Hirofumi Akari

  JOURNAL OF GENERAL VIROLOGY, Jun. 2013, Peer-reviewed

  
• Dynamics of cellular immune responses in the acute phase of dengue virus infection

  Tomoyuki Yoshida; Tsutomu Omatsu; Akatsuki Saito; Yuko Katakai; Yuki Iwasaki; Terue Kurosawa; Masataka Hamano; Atsunori Higashino; Shinichiro Nakamura; Tomohiko Takasaki; Yasuhiro Yasutomi; Ichiro Kurane; Hirofumi Akari

  ARCHIVES OF VIROLOGY, Jun. 2013, Peer-reviewed

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• Presence of viral genome in urine and development of hematuria and pathological changes in kidneys in common marmoset (Callithrix jacchus) after inoculation with dengue virus

  Meng Ling Moi; Tsutomu Omatsu; Takanori Hirayama; Shinichiro Nakamura; Yuko Katakai; Tomoyuki Yoshida; Akatsuki Saito; Shigeru Tajima; Mikako Ito; Tomohiko Takasaki; Hirofumi Akari; Ichiro Kurane

  Pathogens, 13 May 2013, Peer-reviewed

  
• Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells

  Masako Nomaguchi; Naoya Doi; Sachi Fujiwara; Akatsuki Saito; Hirofumi Akari; Emi E. Nakayama; Tatsuo Shioda; Masaru Yokoyama; Hironori Sato; Akio Adachi

  Microbes and Infection, Apr. 2013, Peer-reviewed

  
• TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.

  Akatsuki Saito; Masako Nomaguchi; Ken Kono; Yasumasa Iwatani; Masaru Yokoyama; Yasuhiro Yasutomi; Hironori Sato; Tatsuo Shioda; Wataru Sugiura; Tetsuro Matano; Akio Adachi; E Emi Nakayama; Hirofumi Akari

  The Journal of General Virology, 13 Mar. 2013, Peer-reviewed

  
• Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells.

  Masako Nomaguchi; Masaru Yokoyama; Ken Kono; E Emi Nakayama; Tatsuo Shioda; Akatsuki Saito; Hirofumi Akari; Yasuhiro Yasutomi; Tetsuro Matano; Hironori Sato; Akio Adachi

  Microbes and Infection, Jan. 2013, Peer-reviewed

  
• Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells

  Masako Nomaguchi; Masaru Yokoyama; Ken Kono; Emi E. Nakayama; Tatsuo Shioda; Akatsuki Saito; Hirofumi Akari; Yasuhiro Yasutomi; Tetsuro Matano; Hironori Sato; Akio Adachi

  MICROBES AND INFECTION, Jan. 2013, Peer-reviewed

  
• Epidemiological study of zoonoses derived from humans in captive chimpanzees

  Takanori Kooriyama; Michiko Okamoto; Tomoyuki Yoshida; Toshisada Nishida; Toshio Tsubota; Akatsuki Saito; Masaki Tomonaga; Tetsuro Matsuzawa; Hirofumi Akari; Hidekazu Nishimura; Takako Miyabe-Nishiwaki

  PRIMATES, Jan. 2013, Peer-reviewed

  
• Macaque-tropic human immunodeficiency virus type 1: Breaking out of the host restriction factors

  Akatsuki Saito; Hirofumi Akari

  Frontiers in Microbiology, 2013, Peer-reviewed

  
• Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus

  Tsutomu Omatsu; Meng Ling Moi; Tomohiko Takasaki; Shinichiro Nakamura; Yuko Katakai; Shigeru Tajima; Mikako Ito; Tomoyuki Yoshida; Akatsuki Saito; Hirofumi Akari; Ichiro Kurane

  JOURNAL OF MEDICAL PRIMATOLOGY, Oct. 2012, Peer-reviewed

  
• Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates

  Hitoshi Ohtani; Taeko K. Naruse; Yuki Iwasaki; Hirofumi Akari; Takafumi Ishida; Tetsuro Matano; Akinori Kimura

  IMMUNOGENETICS, Sep. 2012, Peer-reviewed

  
• アカゲザルULBP2/RAET1H遺伝子の多様性解析

  成瀬 妙子; 森 一泰; 明里 宏文; 俣野 哲朗; 木村 彰方

  MHC: Major Histocompatibility Complex, Aug. 2012

  
• 霊長類におけるTIM1遺伝子進化とHIV/AIDS

  木村 彰方; 大谷 仁志; 成瀬 妙子; Sharma Gaurav; Kaur Gurvindar; Mehra Narinder K.; 明里 宏文; 石田 貴文; 俣野 哲朗

  MHC: Major Histocompatibility Complex, Aug. 2012

  
• A Noncanonical mu-1A-Binding Motif in the N Terminus of HIV-1 Nef Determines Its Ability To Downregulate Major Histocompatibility Complex Class I in T Lymphocytes

  Sayuki Iijima; Young-Jung Lee; Hirotaka Ode; Stefan T. Arold; Nobuyuki Kimura; Masaru Yokoyama; Hironori Sato; Yasuhito Tanaka; Klaus Strebel; Hirofumi Akari

  JOURNAL OF VIROLOGY, Apr. 2012, Peer-reviewed

  
• A Noncanonical mu-1A-Binding Motif in the N Terminus of HIV-1 Nef Determines Its Ability To Downregulate Major Histocompatibility Complex Class I in T Lymphocytes

  Sayuki Iijima; Young-Jung Lee; Hirotaka Ode; Stefan T. Arold; Nobuyuki Kimura; Masaru Yokoyama; Hironori Sato; Yasuhito Tanaka; Klaus Strebel; Hirofumi Akari

  JOURNAL OF VIROLOGY, Apr. 2012, Peer-reviewed

  
• Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis).

  Akatsuki Saito; Ken Kono; Masako Nomaguchi; Yasuhiro Yasutomi; Akio Adachi; Tatsuo Shioda; Hirofumi Akari; Emi E Nakayama

  The Journal of general virology, Mar. 2012, Peer-reviewed

  
• Diversity of MHC class I haplotypes in cynomolgus macaques

  Yusuke Saito; Taeko K. Naruse; Hirofumi Akari; Tetsuro Matano; Akinori Kimura

  IMMUNOGENETICS, Feb. 2012, Peer-reviewed

  
• CD16(+) natural killer cells play a limited role against primary dengue virus infection in tamarins

  Tomoyuki Yoshida; Tsutomu Omatsu; Akatsuki Saito; Yuko Katakai; Yuki Iwasaki; Sayuki Iijima; Terue Kurosawa; Masataka Hamano; Shinichiro Nakamura; Tomohiko Takasaki; Yasuhiro Yasutomi; Ichiro Kurane; Hirofumi Akari

  ARCHIVES OF VIROLOGY, Feb. 2012, Peer-reviewed

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• Epidemiological study of zoonotic pathogens by screening of IgA antibodies in wild great apes in Africa.

  Yoshida T; Takemoto H; Sato E; Sakamaki T; Miyabe-Nishiwaki T; Ikoma T; Watanabe A; Kaneko A; Watanabe S; Hayakawa T; Suzuki J; Okamoto M; Matsuzawa T; Akari H; Furuichi T

  International Primatological Society XXIV Congress (2012/08, Cancun, Mexico)., 2012, Peer-reviewed

  
• An alternative tyrosine motif in the N-terminus of HIV-1 Nef determines its activity to down-regulate MHC-I in T lymphocytes

  Iijima S; Lee YJ; Ode H; Arold S; Kimura N; Yokoyama M; Sato H; Tanaka T; Strebel K; Akari H

  Journal of Virology, 2012, Peer-reviewed

  
• RV-4の関与が疑われるニホンザルの血小板減少症

  鈴木樹理; 明里宏文; 岡本宗裕; 吉田友教; 岡林佐知

  オベリスク, 2012

  
• Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H

  Yoshida T; Omatsu T; Saito A; Katakai Y; Iwasaki Y; Kurosawa T; Hamano M; Nakamura S; Takasaki T; Yasutomi Y; Kurane I; Akari H

  Archives of Virology 157:363-368., 2012, Peer-reviewed

  
• Allele frequency of antiretroviral host factor TRIMCyp in wild-caught cynomolgus macaques (Macaca fascicularis)

  Akatsuki Saito; Yoshi Kawamoto; Atsunori Higashino; Tomoyuki Yoshida; Tomoko Ikoma; Yuriko Suzaki; Yasushi Ami; Tatsuo Shioda; Emi E. Nakayama; Hirofumi Akari

  FRONTIERS IN MICROBIOLOGY, 2012, Peer-reviewed

  
• Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

  Hiroaki Takeuchi; Hiroshi Ishii; Tetsuya Kuwano; Natsuko Inagaki; Hirofumi Akari; Tetsuro Matano

  RETROVIROLOGY, Jan. 2012, Peer-reviewed

  
• Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity

  Tsutomu Omatsu; Meng Ling Moi; Takanori Hirayama; Tomohiko Takasaki; Shinichiro Nakamura; Shigeru Tajima; Mikako Ito; Tomoyuki Yoshida; Akatsuki Saito; Yuko Katakai; Hirofumi Akari; Ichiro Kurane

  JOURNAL OF GENERAL VIROLOGY, Oct. 2011, Peer-reviewed

  
• 旧世界ザルにおけるULBP4/RAET1E遺伝子の多様性

  成瀬 妙子; 奥田 裕紀子; 森 一泰; 明里 宏文; 俣野 哲朗; 木村 彰方

  MHC: Major Histocompatibility Complex, Aug. 2011

  
• ULBP4/RAET1E is highly polymorphic in the Old World monkey

  Taeko K. Naruse; Yukiko Okuda; Kazuyasu Mori; Hirofumi Akari; Tetsuro Matano; Akinori Kimura

  IMMUNOGENETICS, Aug. 2011, Peer-reviewed

  
• Molecular evolution of immunoglobulin superfamily genes in primates

  Hitoshi Ohtani; Toshiaki Nakajima; Hirofumi Akari; Takafumi Ishida; Akinori Kimura

  IMMUNOGENETICS, Jul. 2011, Peer-reviewed

  
• Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes

  Mikako Ito; Yuko Katakai; Fumiko Ono; Hirofumi Akari; Ryo-zabro Mukai; Tomohiko Takasaki; Akira Kotaki; Ichiro Kurane

  ARCHIVES OF VIROLOGY, Jun. 2011, Peer-reviewed

  
• Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications

  Akatsuki Saito; Masako Nomaguchi; Sayuki Iijima; Ayumu Kuroishi; Tomoyuki Yoshida; Young-Jung Lee; Toshiyuki Hayakawa; Ken Kono; Emi E. Nakayama; Tatsuo Shioda; Yasuhiro Yasutomi; Akio Adachi; Tetsuro Matano; Hirofumi Akari

  Microbes and Infection, Jan. 2011, Peer-reviewed

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• Diversity of MHC class I haplotypes in cynomolgus macaques

  Saito Y; Naruse TK; Akari H; Matano T; Kimura A

  Immunogenetics, in press. (Epub Sep 1, 2011), 2011, Peer-reviewed

  
• Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications

  Akatsuki Saito; Masako Nomaguchi; Sayuki Iijima; Ayumu Kuroishi; Tomoyuki Yoshida; Young-Jung Lee; Toshiyuki Hayakawa; Ken Kono; Emi E. Nakayama; Tatsuo Shioda; Yasuhiro Yasutomi; Akio Adachi; Tetsuro Matano; Hirofumi Akari

  MICROBES AND INFECTION, Jan. 2011, Peer-reviewed

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• Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets.

  Yuki Iwasaki; Ken-Ichi Mori; Koji Ishii; Noboru Maki; Sayuki Iijima; Tomoyuki Yoshida; Sachi Okabayashi; Yuko Katakai; Young-Jung Lee; Akatsuki Saito; Hiromi Fukai; Nobuyuki Kimura; Naohide Ageyama; Sayaka Yoshizaki; Tetsuro Suzuki; Yasuhiro Yasutomi; Tatsuo Miyamura; Mari Kannagi; Hirofumi Akari

  Frontiers in microbiology, 2011, Peer-reviewed

  
• Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets.

  Yuki Iwasaki; Ken-Ichi Mori; Koji Ishii; Noboru Maki; Sayuki Iijima; Tomoyuki Yoshida; Sachi Okabayashi; Yuko Katakai; Young-Jung Lee; Akatsuki Saito; Hiromi Fukai; Nobuyuki Kimura; Naohide Ageyama; Sayaka Yoshizaki; Tetsuro Suzuki; Yasuhiro Yasutomi; Tatsuo Miyamura; Mari Kannagi; Hirofumi Akari

  Frontiers in microbiology, 2011, Peer-reviewed

  
• Diversity of MHC class I genes in Burmese-origin rhesus macaques

  Taeko K. Naruse; Zhiyong Chen; Risa Yanagida; Tomoko Yamashita; Yusuke Saito; Kazuyasu Mori; Hirofumi Akari; Yasuhiro Yasutomi; Masaaki Miyazawa; Tetsuro Matano; Akinori Kimura

  IMMUNOGENETICS, Sep. 2010, Peer-reviewed

  
• カニクイザル産地別家系調査によるMHCクラスI遺伝子(Mafa-A・B)遺伝子のハプロタイプの決定

  齋藤 祐介; 成瀬 妙子; 明里 宏文; 俣野 哲朗; 保富 康弘; 木村 彰方

  MHC: Major Histocompatibility Complex, Aug. 2010

  
• Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by In Vitro Stimulation Due to the Induction of CCR5

  Yusuke Matsumoto; Tomoyuki Miura; Hirofumi Akari; Yoshitaka Goto; Takeshi Haga

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Aug. 2010, Peer-reviewed

  
• Characterization of natural killer cells in tamarins: a technical basis for studies of innate immunity

  Tomoyuki Yoshida; Akatsuki Saito; Yuki Iwasaki; Sayuki Iijima; Terue Kurosawa; Yuko Katakai; Yasuhiro Yasutomi; Keith A. Reimann; Toshiyuki Hayakawa; Hirofumi Akari

  FRONTIERS IN MICROBIOLOGY, 2010, Peer-reviewed

  
• Dys-Regulated Activation of a Src Tyroine Kinase Hck at the Golgi Disturbs N-Glycosylation of a Cytokine Receptor Fms

  Ranya Hassan; Shinya Suzu; Masateru Hiyoshi; Naoko Takahashi-Makise; Takamasa Ueno; Tsutomu Agatsuma; Hirofumi Akari; Jun Komano; Yutaka Takebe; Kazuo Motoyoshi; Seiji Okada

  JOURNAL OF CELLULAR PHYSIOLOGY, Nov. 2009, Peer-reviewed

  
• Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replication in cynomolgus monkey cells

  Ayumu Kuroishi; Akatsuki Saito; Yasuhiro Shingai; Tatsuo Shioda; Masako Nomaguchi; Akio Adachi; Hirofumi Akari; Emi E. Nakayama

  RETROVIROLOGY, Aug. 2009, Peer-reviewed

  
• Efficient inhibition of SDF-1 alpha-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists

  Yuki Iwasaki; Hirofumi Akari; Tsutomu Murakami; Sei Kumakura; Md Zahidunnabi Dewan; Mikiro Yanaka; Naoki Yamamoto

  CANCER SCIENCE, Apr. 2009, Peer-reviewed

  
• Molecular cloning and characterization of the common marmoset huntingtin gene

  Hirohiko Hohjoh; Hirofumi Akari; Yuko Fujiwara; Yoshiko Tamura; Hirohisa Hirai; Keiji Wada

  GENE, Mar. 2009, Peer-reviewed

  
• Non-human primate surrogate model of hepatitis C virus infection

  Hirofumi Akari; Yuki Iwasaki; Tomoyuki Yoshida; Sayuki Iijima

  MICROBIOLOGY AND IMMUNOLOGY, Jan. 2009, Peer-reviewed

  
• 霊長類飼育実験施設におけるバイオセーフティ

  明里宏文

  NBR Newsletter 5(2):2-5., 2009, Peer-reviewed

  
• MDM2 is a novel E3 ligase for HIV-1 Vif

  Taisuke Izumi; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hiroaki Higashitsuji; Katsuhiko Itoh; Katsuhiro Io; Masashi Matsui; Kazuhiro Iwai; Hiroshi Kondoh; Toshihiro Sato; Mitsunori Tomonaga; Satoru Ikeda; Hirofumi Akari; Yoshio Koyanagi; Jun Fujita; Takashi Uchiyama

  RETROVIROLOGY, Jan. 2009, Peer-reviewed

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• Natural selection in the TLR-related genes in the course of primate evolution

  Toshiaki Nakajima; Hitoshi Ohtani; Yoko Satta; Yasuhiro Uno; Hirofumi Akari; Takafumi Ishida; Akinori Kimura

  IMMUNOGENETICS, Dec. 2008, Peer-reviewed

  
• PREVALENCE AND MOLECULAR PHYLOGENETIC CHARACTERIZATION OF TRYPANOSOMA (MEGATRYPANUM) MINASENSE IN THE PERIPHERAL BLOOD OF SMALL NEOTROPICAL PRIMATES AFTER A QUARANTINE PERIOD

  Hiroshi Sato; Natalie Leo; Yuko Katakai; Jun-ichiro Takano; Hirofumi Akari; Shin-ichiro Nakamura; Yumi Une

  JOURNAL OF PARASITOLOGY, Oct. 2008, Peer-reviewed

  
• Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial

  Miki Kawada; Tetsuo Tsukamoto; Hiroyuki Yamamoto; Nami Iwamoto; Kyoko Kurihara; Akiko Takeda; Chikaya Moriya; Hiroaki Takeuchi; Hirofumi Akari; Tetsuro Matano

  JOURNAL OF VIROLOGY, Oct. 2008, Peer-reviewed

  
• Cloning and characterization of the common marmoset huntingtin gene

  Hohjoh Hirohiko; Fujiwara Yuko; Akari Hirofumi; Tamura Yoshiko; Wada Keiji

  NEUROSCIENCE RESEARCH, 2008, Peer-reviewed

  
• Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor

  Masateru Hiyoshi; Shinya Suzu; Yuka Yoshidomi; Ranya Hassan; Hideki Harada; Naomi Sakashita; Hirofumi Akari; Kazuo Motoyoshi; Seiji Okada

  BLOOD, Jan. 2008, Peer-reviewed

  
• Detection of SRV/D shedding in body fluids of cynomolgus macaques and comparison of partial gp70 sequences in SRV/D-T isolates

  Masayuki Hara; Toshihiko Kikuchi; Tetsutaro Sata; Noriko Nakajima; Yasushi Ami; Yuko Sato; Keiko Tanaka; Toyoko Narita; Fumiko Ono; Hirofumi Akari; Keiji Terao; Ryozaburo Mukai

  VIRUS GENES, Oct. 2007, Peer-reviewed

  
• Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.

  Takanori Yokota; Sayuki Iijima; Takayuki Kubodera; Koji Ishii; Yuko Katakai; Naohide Ageyama; Yingwei Chen; Young-Jung Lee; Toshinori Unno; Kazutaka Nishina; Yuki Iwasaki; Noboru Maki; Hidehiro Mizusawa; Hirofumi Akari

  Biochemical and biophysical research communications, 21 Sep. 2007, Peer-reviewed

  
• GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo.

  Koji Ishii; Sayuki Iijima; Nobuyuki Kimura; Young-Jung Lee; Naohide Ageyama; Shintaro Yagi; Kenjiro Yamaguchi; Noboru Maki; Ken-Ichi Mori; Sayaka Yoshizaki; Sanae Machida; Tetsuro Suzuki; Naoko Iwata; Tetsutaro Sata; Keiji Terao; Tatsuo Miyamura; Hirofumi Akari

  Microbes and infection, Apr. 2007, Peer-reviewed

  
• Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex

  K Shirakawa; A Takaori-Kondo; M Kobayashi; M Tomonaga; T Izumi; K Fukunaga; A Sasada; A Abudu; Y Miyauchi; H Akari; K Iwai; T Uchiyama

  VIROLOGY, Jan. 2006, Peer-reviewed

  
• Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation

  M Fujita; H Akari; A Sakurai; A Yoshida; T Chiba; K Tanaka; K Strebel; A Adachi

  MICROBES AND INFECTION, Jul. 2004, Peer-reviewed

  
• Detection of 14 alleles derived from the MHC class I A locus in cynomolgus monkeys

  A Uda; K Tanabayashi; YK Yamada; H Akari; YJ Lee; R Mukai; K Terao; A Yamada

  IMMUNOGENETICS, Jun. 2004, Peer-reviewed

  
• High level expression of human immunodeficiency virus type-1 Vif inhibits viral infectivity by modulating proteolytic processing of the gag precursor at the p2/nucleocapsid processing site

  H Akari; M Fujita; S Kao; MA Khan; M Shehu-Xhilaga; A Adachi; K Strebel

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2004, Peer-reviewed

  
• Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression

  KL Nguyen; M Llano; H Akari; E Miyagi; EM Poeschla; K Strebel; S Bour

  VIROLOGY, Feb. 2004, Peer-reviewed

  
• Age-related increase of peripheral CD4(+) CD8(+) double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution

  WW Lee; KH Nam; K Terao; H Akari; Y Yoshikawa

  IMMUNOLOGY, Jun. 2003, Peer-reviewed

  
• Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV

  M Fujita; A Yoshida; A Sakurai; J Tatsuki; F Ueno; H Akari; A Adachi

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, May 2003, Peer-reviewed

  
• Vpx and Vpr proteins of HIV-2 up-regulate the viral infectivity by a distinct mechanism in lymphocytic cells

  F Ueno; H Shiota; M Miyaura; A Yoshida; A Sakurai; J Tatsuki; AH Koyama; H Akari; A Adachi; M Fujita

  MICROBES AND INFECTION, Apr. 2003, Peer-reviewed

  
• Naturally occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release

  S Bour; H Akari; E Miyagi; K Strebel

  VIROLOGY, Apr. 2003, Peer-reviewed

  
• nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes

  C Sugimoto; K Tadakuma; Otani, I; T Moritoyo; H Akari; F Ono; Y Yoshikawa; T Sata; S Izumo; K Mori

  JOURNAL OF VIROLOGY, Apr. 2003, Peer-reviewed

  
• Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection

  S Kao; H Akari; MA Khan; M Dettenhofer; XF Yu; M Strebel

  JOURNAL OF VIROLOGY, Jan. 2003, Peer-reviewed

  
• Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease may be correlated with Vif function

  MA Khan; H Akari; S Kao; C Aberham; D Davis; A Buckler-White; K Strebel

  JOURNAL OF VIROLOGY, Sep. 2002, Peer-reviewed

  
• Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type I-specific CD8(+) T-cell cytolytic activity and cytokine production

  H Tomiyama; H Akari; A Adachi; M Takiguchi

  JOURNAL OF VIROLOGY, Aug. 2002, Peer-reviewed

  
• Different effects of nef-mediated HLA class I down-regulation on HIV-1-specific CD8(+) T cell cytolytic activity and cytokine production

  H Tomiyama; H Akari; A Adachi; M Takiguchi

  XIV INTERNATIONAL AIDS CONFERENCE: BASIC SCIENCES, 2002, Peer-reviewed

  
• The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappa B-dependent expression of antiapoptotic factors

  H Akari; S Bour; S Kao; A Adachi; K Strebel

  JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2001, Peer-reviewed

  
• Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC)gag capsid region

  M Fujita; A Yoshida; M Miyaura; A Sakurai; H Akari; AH Koyama; A Adachi

  JOURNAL OF VIROLOGY, Nov. 2001, Peer-reviewed

  
• Human immunodeficiency virus type I Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA

  MA Khan; C Aberham; S Kao; H Akari; R Gorelick; S Bour; K Strebel

  JOURNAL OF VIROLOGY, Aug. 2001, Peer-reviewed

  
• The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of I kappa B

  S Bour; C Perrin; H Akari; K Strebel

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2001, Peer-reviewed

  
• MHC-I expression in HTLV-1-positive and -negative cells

  A Yoshida; M Miyaura; A Sakurai; T Fukumori; M Fujita; H Akari; A Adachi

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Jul. 2000, Peer-reviewed

  
• Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys

  KH Nam; H Akari; K Terao; H Shibata; S Kawamura; Y Yoshikawa

  INTERNATIONAL IMMUNOLOGY, Jul. 2000, Peer-reviewed

  
• Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr

  T Fukumori; H Akari; A Yoshida; M Fujita; AH Koyama; S Kagawa; A Adachi

  MICROBES AND INFECTION, Jul. 2000, Peer-reviewed

  
• Host cell-dependent replication of HIV-1 mutants with deletions in gp41 cytoplasmic tail region is independent of the function of Vif

  H Akari; A Yoshida; T Fukumori; A Adachi

  MICROBES AND INFECTION, Jul. 2000, Peer-reviewed

  
• Cell-dependent requirement of human immunodeficiency virus type 1 gp41 cytoplasmic tail for Env incorporation into virions

  H Akari; T Fukumori; A Adachi

  JOURNAL OF VIROLOGY, May 2000, Peer-reviewed

  
• Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

  H Akari; S Arold; T Fukumori; T Okazaki; K Strebel; A Adachi

  JOURNAL OF VIROLOGY, Mar. 2000, Peer-reviewed

  
• Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of Vif for optimal infectivity: functional difference between Vif and Nef

  H Akari; T Uchiyama; T Fukumori; S Iida; AH Koyama; A Adachi

  JOURNAL OF GENERAL VIROLOGY, Nov. 1999, Peer-reviewed

  
• Effective delivery of a lipophilic 6-chloro-2 ',3 '-dideoxyguanosine (6-Cl-ddG) into rat lymphoid tissues

  Y Fujii; H Akari; M Machida; E Kojima; K Murakami; Y Yoshikawa

  EXPERIMENTAL ANIMALS, Oct. 1999, Peer-reviewed

  
• Accumulation of MAC387(+) macrophages in paracortical areas of lymph nodes in rhesus monkeys acutely infected with simian immunodeficiency virus

  Otani, I; K Mori; K Terao; K Doi; H Akari; Y Yoshikawa

  MICROBES AND INFECTION, Oct. 1999, Peer-reviewed

  
• Induction of apoptosis in Herpesvirus saimiri-immortalized T lymphocytes by blocking interaction of CD28 with CD80/CD86

  H Akari; T Fukumori; S Iida; A Adachi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1999, Peer-reviewed

  
• Effects of SIVmac infection on peripheral blood CD4(+)CD8(+) T lymphocytes in cynomolgus macaques

  H Akari; KH Nam; K Mori; Otani, I; H Shibata; A Adachi; K Terao; Y Yoshikawa

  CLINICAL IMMUNOLOGY, Jun. 1999, Peer-reviewed

  
• Compatibility of Vpu-like activity in the four groups of primate immunodeficiency viruses

  S Iida; T Fukumori; Y Oshima; H Akari; AH Koyama; A Adachi

  VIRUS GENES, Apr. 1999, Peer-reviewed

  
• Mutational analysis of human immunodeficiency virus type 1 vif gene

  K Sakai; M Horiuchi; S Iida; T Fukumori; H Akari; A Adachi

  VIRUS GENES, Apr. 1999, Peer-reviewed

  
• Rev-dependent expression of three species of HIV-1 mRNAs (Review)

  Tomoharu Fukumori; Susumu Kagawa; Shinya Iida; Yoko Oshima; Hirofumi Akari; A. Hajime Koyama; Akio Adachi

  International Journal of Molecular Medicine, 1999, Peer-reviewed

  
• Exchangeability of accessory Vif and Vpu proteins between various HIV/SIVs (Review)

  Akio Adachi; Shinya Iida; Tomoharu Fukumori; Michio Tamaki; Ritsuko Inubushi; Reika Shimano; Yoko Oshima; A. Hajime Koyama

  International Journal of Molecular Medicine, 1999, Peer-reviewed

  
• Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent

  K Tokunaga; A Kojima; T Kurata; K Ikuta; H Akari; AH Koyama; M Kawamura; R Inubushi; R Shimano; A Adachi

  JOURNAL OF GENERAL VIROLOGY, Oct. 1998, Peer-reviewed

  
• Functional roles of HIV accessory proteins for viral replication (Review)

  R Inubushi; M Tamaki; R Shimano; AH Koyama; H Akari; A Adachi

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Oct. 1998, Peer-reviewed

  
• Producer cell-dependent requirement of the nef protein for efficient entry of HIV-1 into cells

  K Tokunaga; A Kojima; T Kurata; K Ikuta; R Inubushi; R Shimano; M Kawamura; H Akari; AH Koyama; A Adachi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1998, Peer-reviewed

  
• Phenotypic changes in peripheral blood monocytes of cynomolgus monkeys acutely infected with simian immunodeficiency virus

  Otani, I; H Akari; KH Nam; K Mori; E Suzuki; H Shibata; K Doi; K Terao; Y Yosikawa

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Sep. 1998, Peer-reviewed

  
• Role of virus-induced apoptosis in a host defense mechanism against virus infection

  A. Hajime Koyama; Hiroshi Irie; Tomoharu Fukumori; So Hata; Shinya Iida; Hirofumi Akari; Akio Adachi

  Journal of Medical Investigation, Aug. 1998, Peer-reviewed

  
• The HIV-1 Vpr displays strong anti-apoptotic activity

  T Fukumori; H Akari; S Iida; S Hata; S Kagawa; Y Aida; AH Koyama; A Adachi

  FEBS LETTERS, Jul. 1998, Peer-reviewed

  
• Early function of HIV-1 Gag proteins is cell-dependent

  M Kawamura; R Shimano; R Inubushi; H Akari; A Adachi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1998, Peer-reviewed

  
• Age-related changes in major lymphocyte subsets in cynomolgus monkeys

  KH Nam; H Akari; K Terao; S Itagaki; Y Yoshikawa

  EXPERIMENTAL ANIMALS, Jul. 1998, Peer-reviewed

  
• Induction of MHC-IIDR expression on circulating CD8(+) lymphocytes in macaques infected with SIVmac239 nef-open but not with its nef-deletion mutant

  H Akari; K Mori; Otani, I; K Terao; F Ono; A Adachi; Y Yoshikawa

  AIDS RESEARCH AND HUMAN RETROVIRUSES, May 1998, Peer-reviewed

  
• Selective expression of beta 7 integrin on lymphocytes undergoing apoptosis in lymphoid tissues

  H Akari; H Yagita; T Nishida; K Nakamaru; K Terao; Y Yoshikawa; A Adachi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 1998, Peer-reviewed

  
• Age-dependent remodeling of peripheral blood CD4(+) CD8(+) T lymphocytes in Cynomolgus monkeys

  KH Nam; H Akari; K Terao; H Ohto; S Itagaki; Y Yoshikawa

  DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Mar. 1998, Peer-reviewed

  
• Simian T cell leukemia virus type I induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: Implication of CD8(+) T cell leukemia

  H Akari; F Ono; Sakakibara, I; H Takahashi; Y Murayama; A Hiyaoka; K Terao; Otani, I; R Mukai; A Adachi; Y Yoshikawa

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Mar. 1998, Peer-reviewed

  
• Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil

  Hirofumi Akari; Yoshihiko Yamamoto; Hiroko Hiwada; Yasuyoshi Saito; Noriyasu Takayanagi; A. Hajime Koyama; Akio Adachi

  Journal of Medical Investigation, Feb. 1998, Peer-reviewed

  
• The non-env tropism of HIV/SIV.

  Shimano, R; Inubushi, R; Tamaki, M; Akari, H; Koyama, A.H; Adachi, A

  International Journal of Molecular Medicine, 1998, Peer-reviewed

  
• Antiviral effects of 6-chloro-2 ',3 '-dideoxyguanosine in rhesus monkeys acutely infected with simian immunodeficiency virus

  Y Fujii; R Mukai; H Akari; M Machida; K Mori; M Takasaka; E Kojima; K Murakami; Y Yoshikawa

  ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, Jan. 1998, Peer-reviewed

  
• Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2

  AH Koyama; H Akari; A Adachi; F Goshima; Y Nishiyama

  ARCHIVES OF VIROLOGY, 1998, Peer-reviewed

  
• Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency

  M Kawamura; R Shimano; T Ogasawara; R Inubushi; K Amano; H Akari; A Adachi

  ARCHIVES OF VIROLOGY, 1998, Peer-reviewed

  
• Complete inhibition of SIVmac replication by its capsid mutants

  R Shimano; R Inubushi; K Amano; T Ogasawara; H Akari; AH Koyama; M Kawamura; A Adachi

  VIRUS GENES, 1998, Peer-reviewed

  
• Comparative analysis of human and macaque monkey CD4: Differences in formaldehyde lability and conformation

  H Akari; K Terao; KH Nam; A Adachi; Y Yoshikawa

  EXPERIMENTAL ANIMALS, Jan. 1998, Peer-reviewed

  
• Efficacy of 6-chloro-2 ',3 '-dideoxyguanosine (6-Cl-ddG) on rhesus macaque monkeys chronically infected with simian immunodeficiency virus (SIVmac239)

  Y Fujii; R Mukai; K Mori; H Akari; Otani, I; F Ono; E Kojima; M Takasaka; M Machida; K Murakami; Y Yoshikawa

  JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Dec. 1997, Peer-reviewed

  
• Functional domain mapping of HIV-1 gag proteins

  M Kawamura; R Shimano; R Inubushi; K Amano; T Ogasawara; H Akari; A Adachi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1997, Peer-reviewed

  
• Effects of 6-chloro-2', 3'-dideoxyguanosine (6-Cl-ddG) in surface lymph nodes of rhesus monkeys (Macaca mulatta) chronically infected with simian immunodeficiency virus (SIVmac239)

  Otani, I; Y Fujii; H Akari; R Mukai; K Mori; F Ono; E Kojima; M Machida; K Murakami; K Doi; Y Yoshikawa

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Oct. 1997, Peer-reviewed

  
• HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases

  RA Furuta; R Shimano; T Ogasawara; R Inubushi; K Amano; H Akari; M Hatanaka; M Kawamura; A Adachi

  FEBS LETTERS, Sep. 1997, Peer-reviewed

  
• Cleavage of Gag precursor is required for early replication phase of HIV-1

  M Kawamura; R Shimano; R Inubushi; K Amano; T Ogasawara; H Akari; A Adachi

  FEBS LETTERS, Sep. 1997, Peer-reviewed

  
• Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization

  H Akari; T Suzuki; K Ikeda; H Hoshino; T Tomono; T Murotsuka; K Terao; H Ito; Y Yoshikawa

  VACCINE, Aug. 1997, Peer-reviewed

  
• Peripheral blood CD4(+)CD8(+) lymphocytes in cynomolgus monkeys are of resting memory T lineage

  H Akari; K Terao; Y Murayama; KH Nam; Y Yoshikawa

  INTERNATIONAL IMMUNOLOGY, Apr. 1997, Peer-reviewed

  
• Peripheral blood CD4(+)CD8(+) lymphocytes in cynomolgus monkeys are of resting memory T lineage

  H Akari; K Terao; Y Murayama; KH Nam; Y Yoshikawa

  INTERNATIONAL IMMUNOLOGY, Apr. 1997, Peer-reviewed

  
• Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers

  Mari Kannagi; Tahei Nakamura; Hirofumi Akari; Marcelo J. Kuroda; Masahiro Fujii; Shinichi Oka; Aikichi Iwamoto; Takeshi Kurata; Daisuke Higashi; Shinji Harada

  Leukemia, 1997, Peer-reviewed

  
• Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus

  Y Fujii; R Mukai; Y Murayama; H Akari; M Machida; K Mori; M Takasaka; K Murakami; Y Yoshikawa

  EXPERIMENTAL ANIMALS, Jan. 1997, Peer-reviewed

  
• In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus Saimiri: Its susceptibility to infection with simian immunodeficiency viruses

  H Akari; K Mori; K Terao; Otani, I; M Fukasawa; R Mukai; Y Yoshikawa

  VIROLOGY, Apr. 1996, Peer-reviewed

  
• DETECTION OF THE CELLULAR MEMBRANE-PROTEINS ON HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I

  H AKARI; Y GOTO; T SHINJO

  ARCHIVES OF VIROLOGY, 1995, Peer-reviewed

  
• Differential reactivities of antibodies to HIV and HTLV-I in sera of suspected AIDS and ARC patients.

  M. Aidoo; O. Nishiwaki; H. Akari; J.A. Brandful; W. Ampofo; M. Hayami; N.K. Ayisi

  West African Journal of Medicine, Jul. 1994, Peer-reviewed

  
• EXPOSURE OF P19 MATRIX PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I (HTLV-I) ON THE SURFACE OF MOLT-4-NUMBER-8 CELLS AFTER VIRUS ADSORPTION

  H AKARI; MJ KURODA; T SHINJO; MA ELFARRASH; S HARADA

  ARCHIVES OF VIROLOGY, 1994, Peer-reviewed

  
• SIMPLE ASSAY SYSTEM FOR DETECTING HUMAN-T CELL LEUKEMIA-VIRUS TYPE I-BINDING CELLS AND ITS APPLICATION IN TITRATING BINDING INHIBITORY ANTIBODIES

  H AKARI; M KANNAGI; T SHINJO; S HARADA

  LABORATORY INVESTIGATION, Nov. 1993, Peer-reviewed

  
• ISOLATION AND CHARACTERIZATION OF SIMIAN IMMUNODEFICIENCY VIRUS FROM AFRICAN WHITE-CROWNED MANGABEY MONKEYS (CERCOCEBUS-TORQUATUS-LUNULATUS)

  K TOMONAGA; J KATAHIRA; M FUKASAWA; MA HASSAN; M KAWAMURA; H AKARI; T MIURA; T GOTO; M NAKAI; M SULEMAN; M ISAHAKIA; M HAYAMI

  ARCHIVES OF VIROLOGY, 1993, Peer-reviewed

  
• ISOLATION AND CHARACTERIZATION OF A HIGHLY DIVERGENT HIV-2[GH-2] - GENERATION OF AN INFECTIOUS MOLECULAR CLONE AND FUNCTIONAL-ANALYSIS OF ITS REV-RESPONSIVE ELEMENT IN RESPONSE TO PRIMATE RETROVIRUS TRANSACTIVATORS (REV AND REX)

  M KAWAMURA; J KATAHIRA; M FUKASAWA; JI SAKURAGI; KI ISHIKAWA; M NAKAI; JAA MINGLE; M OSEIKWASI; VBA NETTY; H AKARI; O HISHIDA; K TOMONAGA; T MIURA; M HAYAMI

  VIROLOGY, Jun. 1992, Peer-reviewed

  
• BIOLOGICAL CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND TYPE-2 MUTANTS IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

  H AKARI; J SAKURAGI; Y TAKEBE; K TOMONAGA; M KAWAMURA; M FUKASAWA; T MIURA; T SHINJO; M HAYAMI

  ARCHIVES OF VIROLOGY, 1992, Peer-reviewed

  
• FUNCTIONAL-ANALYSIS OF LONG TERMINAL REPEATS DERIVED FROM 4 STRAINS OF SIMIAN IMMUNODEFICIENCY VIRUS SIVAGM IN RELATION TO OTHER PRIMATE LENTIVIRUSES

  J SAKURAGI; M FUKASAWA; R SHIBATA; H SAKAI; M KAWAMURA; H AKARI; T KIYOMASU; A ISHIMOTO; M HAYAMI; A ADACHI

  VIROLOGY, Nov. 1991, Peer-reviewed

  
• ESTABLISHMENT OF A PHYLOGENETIC SURVEY SYSTEM FOR AIDS-RELATED LENTIVIRUSES AND DEMONSTRATION OF A NEW HIV-2 SUBGROUP

  T MIURA; J SAKURAGI; M KAWAMURA; M FUKASAWA; EN MORIYAMA; T GOJOBORI; K ISHIKAWA; JAA MINGLE; VBA NETTEY; H AKARI; M ENAMI; H TSUJIMOTO; M HAYAMI

  AIDS, Dec. 1990, Peer-reviewed

  
• Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro

  Yohei Seki; Tomoya Kitamura; Kenta Tezuka; Megumi Murata; Hirofumi Akari; Isao Hamaguchi; Kazu Okuma

  Viruses, 31 Mar. 2022, Peer-reviewed

  

Misc.

• STLV-1特異的CTLの低応答性を示すSTLV-1自然感染ニホンザルに対する自家末梢血単核球の免疫接種によるCTL応答の回復

  神奈木真理; 神奈木真理; 長谷川温彦; 長谷川温彦; 村田めぐみ; 中嶋伸介; 藤澤順一; 大隈和; 明里宏文

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2022

  
• STLV-1自然感染ニホンザルを用いた水平感染様式解明に向けた検討

  関洋平; 手塚健太; 平舘裕希; 水上拓郎; 倉光球; 大隈和; 大隈和; 村田めぐみ; 明里宏文; 明里宏文; 浜口功

  日本HTLV-1学会学術集会, 2021

  
• 肝炎ウイルスとワクチン—Hepatitis viruses and vaccines

  加藤 孝宣; 明里 宏文

  臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会 編, May 2023

  
• B型肝炎ワクチン—Neutralization of hepatitis B virus with vaccine-escape mutations by novel hepatitis B vaccine with large-HBs antigen

  加藤 孝宣; 明里 宏文

  ウイルス = Virus / 日本ウィルス学会 編, Dec. 2022

  
• 初期感染期におけるnef遺伝子によるSIVの感染様式の制御

  森 一泰; 大谷 功; 明里 宏文; 佐多 徹太郎; 小野 文子; 寺尾 恵治; 向井 錦三郎; 高阪 楕夫; 土井 邦雄; 吉川 泰弘

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent.

  Tokunaga Kenzo; Kojima Asato; Kurata Takeshi; Ikuta Kazuyoshi; Akari Hirofumi; Koyama Hajime; Kawamura Meiko; Inubushi Ritsuko; Shimano Reika; Adachi Akio

  Collected papers from the Institute of Immunological Science Hokkaido University, 1998

  
• Producer cell-dependent requirement of the Nef protein for efficient entry of HIV-1 into cells.

  Tokunaga Kenzo; Kojima Asato; Kurata Takeshi; Ikuta Kazuyoshi; Inubushi Ritsuko; Shimano Reika; Kawamura Meiko; Akari Hirofumi; Koyama A. Hajime; Adachi Akio

  Collected papers from the Institute of Immunological Science Hokkaido University, 1998

  
• 人類進化モデル研究センター(III.研究活動)

  平井 啓久; 明里 宏文; 岡本 宗裕; 鈴木 樹理; 宮部 貴子; 早川 敏之; 吉田 友教; 阿部 政光; 釜中 慶朗; 前田 典彦; 渡邉 朗野; 森本 真弓; 兼子 明久; 渡邉 祥平; 須田 直子

  霊長類研究所年報, 21 Oct. 2011

  Access this misc :

  
• 人類進化モデル研究センター(III.研究活動)

  平井 啓久; 松林 清明; 景山 節; 明里 宏文; 鈴木 樹理; 宮部 貴子; 早川 敏之; 熊崎 清則; 阿部 政光; 釜中 慶朗; 前田 典彦; 渡邉 朗野; 森本 真弓; 兼子 明久; 渡邉 祥平; 須田 直子

  霊長類研究所年報, 21 Sep. 2010

  Access this misc :

  
• 低CTL応答を示すSTLV-1感染ニホンザルに対するCTL活性化型ワクチンの効果

  長谷川温彦; 村田めぐみ; 片桐邦子; 鷲崎彩夏; 明里宏文; 増田貴夫; 神奈木真理

  日本HTLV-1学会学術集会, 2021

  
• 実験動物感染症の現状 サルT細胞白血病ウイルス(simian T-cell leukemia virus: STLV)

  明里 宏文; 村田 めぐみ

  Experimental animals, Apr. 2016

  
• STLV-1感染ニホンザルによるHTLV-1標的ウイルス療法の開発に向けた検討

  大隈和; 倉光球; 手塚健太; 水上拓郎; 村田めぐみ; 明里宏文; 浜口功

  日本実験動物学会総会講演要旨集(Web), 2020

  
• in vivo passageで獲得したサル馴化HIV-1のvif遺伝子領域における欠損変異の役割

  松岡和弘; 中田佳宏; 鷲﨑彩夏; 芳田剛; 齊藤暁; 大出裕高; 関洋平; 保富康宏; 俣野哲朗; 三浦智行; 蜂谷敦子; 今橋真弓; 横幕能行; 明里宏文; 岩谷靖雅

  第33回日本エイズ学会学術集会・総会. 2019年11月27-29日、熊本, Nov. 2019, Peer-reviewed

  
• PKC活性化剤とBET阻害剤の併用によるHIV再活性化能及び毒性への効果

  鷲崎彩夏; 村田めぐみ; 関洋平; Yin Pui Tang; Tan Wei Keat; 入江一浩; 明里宏文

  第33回日本エイズ学会学術集会・総会. 2019年11月27-29日、熊本, Nov. 2019, Peer-reviewed, Corresponding author

  
• HIV-1潜伏感染霊長類モデルにおけるHIV複製リザーバーの定量解析とその意義

  関洋平; 齊藤暁; 原田恵嘉; 村田めぐみ; 鷲崎彩夏; 引地優太; 吉村和久; 石井洋; 佐藤賢文; Islam M Saiful; 大出裕高; 岩谷靖雅; 芳田剛; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第33回日本エイズ学会学術集会・総会. 2019年11月27-29日、熊本, Nov. 2019, Peer-reviewed, Corresponding author

  
• Active reservoir size in lymph node may determine the present status and predict the outcome of HIV-1 controller

  Yohei Seki; Ayaka Washizaki; Akatsuki Saito; Shigeyoshi Harada; Megumi Murata; Wei Keat Tan; Yuta Hikichi; Kazuhisa Yoshimura; Hiroshi Ishii; Yorifumi Satou; Islam Mohammad Saiful; Hirotaka Ode; Yasumasa Iwatani; Takeshi Yoshida; Yasuhiro Yasutomi; Tetsuro Matano; Tomoyuki Miura; Hirofumi Akari

  The 37th Annual Symposium on Nonhuman Primate Models for AIDS. November 12-15, 2019, San Antonio, Nov. 2019, Peer-reviewed, Corresponding author

  
• 組換えVSVによる抗HTLV-1ウイルス療法の開発に向けたSTLV-1感染ニホンザルのHTLV-1感染霊長類モデルへの応用

  大隈和; 倉光球; 手塚健太; 水上拓郎; 村田めぐみ; 明里宏文; 浜口功

  第67回日本ウイルス学会学術集会. 2019年10月29日～31日、東京, Oct. 2019, Peer-reviewed

  
• 母子感染における抗体価・PVLの動態の長期的調査 〜STLV-1自然感染ニホンザルを用いて〜

  村田めぐみ; 鷲崎彩夏; 関洋平; Wei Keat TAN; 森本真弓; 兼子明久; 夏目尊好; 鈴木樹理; 安永純一朗; 松岡雅雄; 水上拓郎; 明里宏文

  第6回日本HTLV-1学会学術集会．2019年8月23日〜25日、宮崎, Aug. 2019, Peer-reviewed, Corresponding author

  
• ニホンザル (Macaca fuscata) のSTLV-1ゲノム解析

  北村知也; 倉光球; 手塚健太; 水上拓郎; 明里宏文; 村田めぐみ; 大隈和; 浜口功

  第6回日本HTLV-1学会学術集会．2019年8月23日〜25日、宮崎, Aug. 2019, Peer-reviewed

  
• ヒト化マウスを用いたHTLV-1母子感染モデルの構築の試み

  水上拓郎; 野島清子; 佐藤結子; 古畑啓子; 松岡佐保子; 大隈和; 森内浩幸; 内丸薫; 明里宏文; 蕎麦田理英子; 佐竹正博; 浜口功

  第6回日本HTLV-1学会学術集会．2019年8月23日〜25日、宮崎, Aug. 2019, Peer-reviewed

  
• HTLV-1及びSTLV-1プロウイルス配列の網羅的解析

  七條敬文; 安永純一朗; 大西知帆; 志村和也; 高起良; 竹之内徳博; 佐藤佳; 小柳義夫; 明里宏文; 野坂生郷; 松岡雅雄

  第6回日本HTLV-1学会学術集会．2019年8月23日〜25日、宮崎, Aug. 2019, Peer-reviewed

  
• HTLV-1感染に対するウイルス療法確立に向けた腫瘍溶解性VSVの霊長類薬剤評価系の構築

  大隈和; 手塚健太; 北村知也; 倉光球; 水上拓郎; 村田めぐみ; 明里宏文; 浜口功

  第6回日本HTLV-1学会学術集会．2019年8月23日〜25日、宮崎, Aug. 2019, Peer-reviewed

  
• Development of humanized mouse model for studying mother to child HTLV-1 transmission and prevention with HTLV-1 antibody treatment

  Takuo Mizukami; Kiyoko Nojima; Yuko Sato; Keiko Furuhata; Eita Sasaki; Sahoko Matsuoka; Kazu Okuma; Hiroyuki Moriuchi; Kaoru Uchimaru; Hirofumi Akari; Masahiro Satake; Isao Hamaguchi

  24th Congress of Europian Hematology Association, June 14-17, 2019, Stockholm, Jun. 2019, Peer-reviewed

  
• サル感染モデルを用いたHTLV-1治療薬評価に向けた検討

  大隈和; 倉光球; 手塚健太; 水上拓郎; 村田めぐみ; 明里宏文; 浜口功

  日本実験動物学会総会講演要旨集(Web), 2019

  
• 新規PKC活性化剤10-Methyl-Aplog-1とJQ1の併用はLatency Reversing Agentとして理想的な活性を示す

  鷲崎彩夏; 村田めぐみ; 関洋平; Yin Pui Tang; 寒川裕之; Wei Keat Tan; 入江一浩; 明里宏文

  第32回 日本エイズ学会学術集会, 02 Dec. 2018, Peer-reviewed

  
• HIV感染霊長類モデルによるHIV根治研究

  明里宏文

  第32回 日本エイズ学会学術集会, 02 Dec. 2018, Peer-reviewed

  
• 新しいHIV感染霊長類モデル：HIV感染症の根治に向けて

  明里宏文

  第14回霊長類医科学フォーラム（講演）, 09 Nov. 2018, Peer-reviewed

  
• A novel PKC actvator 10-Methyl-Aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapy

  Ayaka Washizaki; Megumi Murata; Yohei Seki; Yin Pui Tang; Hiroyuki Kangawa; Tan Wei Keat; Kazuhiro Irie; Hirofumi Akari

  36th Annual Symposium Nonhuman Primate Models for AIDS, 28 Oct. 2018, Peer-reviewed

  
• Cooperative cellular and humoral immunity may contribute to the efficient control of HIV-1 replication in macaques

  Yohei Seki; Akatsuki Saito; Shigeyoshi Harada; Ayaka Washizaki; Megumi Murata; Yuta Hikichi; Kazuhisa Yoshimura; Hiroshi Ishii; Yorifumi Satou; Islam Mohammad Saiful; Hirotaka Ode; Yasumasa Iwatani; Takeshi Yoshida; Yasuhiro Yasutomi; Tetsuro Matano; Tomoyuki Miura; Hirofumi Akari

  36th Annual Symposium Nonhuman Primate Models for AIDS, 28 Oct. 2018, Peer-reviewed

  
• Molecular characterization of the env gene during transmission of macaque-tropic human immunodeficiency virus type 1 (HIV-1mt)

  Shigeyoshi Harada; Yuta Hikichi; Yohei Seki; Yasumasa Iwatani; Yasuhiro Yasutomi; Tomoyuki Miura; Tetsuro Matano; Hirofumi Akari; Kazuhisa Yoshimura

  36th Annual Symposium Nonhuman Primate Models for AIDS, 28 Oct. 2018, Peer-reviewed

  
• A novel PKC activator 10-Methyl-Aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapy

  Ayaka Washizaki; Megumi Murata; Yohei Seki; Yin Pui Tang; Hiroyuki Kangawa; Kazuhiro Irie; Hirofumi Akari

  66th Annual Meeting of the Japanese Society for Virology, 28 Oct. 2018, Peer-reviewed

  
• Frequent horizontal transmission is associated with high prevalence of STLV-1 infection_in Japanese macaques

  Megumi Murata; Ayaka Washizaki; Jun-ichiro Yasunaga; Yohei Seki; Masao Matsuoka; Hirofumi Akari

  66th Annual Meeting of the Japanese Society for Virology, 28 Oct. 2018, Peer-reviewed

  
• A novel PKC activator, 10-methyl-aplog-1 efficiently reactivate latent HIV-1 in combination with a BET inhibitor JQ1

  Ayaka Washizaki; Megumi Murata; Yin Pui Tang; Yohei Seki; Kazuhiro Irie; Hirofumi Akari

  JOURNAL OF MEDICAL PRIMATOLOGY, Oct. 2018

  
• ヒト化マウスを用いたHTLV-1母子感染モデルの構築と機序解明

  水上 拓郎; 野島 清子; 古畑啓子; 佐藤結子; 蕎麦田理英子; 松岡 佐保子; 松本千恵子; 大隈 和; 明里 宏文; 佐竹正博; 森内 浩幸; 斎藤 滋; 内丸 薫; 口 功

  第161回日本獣医学会学術集会, 11 Sep. 2018, Peer-reviewed

  
• STLV-1自然感染ニホンザルにおけるSTLV-1特異的T細胞免疫の低応答性

  冨士川朋夏; 長谷川温彦; ndrakh Ganbaatar; 永野佳子; 増田貴夫; 田中勇悦; 村田めぐみ; 明里宏文; 神奈木真理

  第5回日本HTLV-1学会学術集会, 31 Aug. 2018, Peer-reviewed

  
• ニホンザルにおける高頻度なSTLV-1自然感染に関する疫学調査

  村田めぐみ; 鷲崎彩夏; 関洋平; 安永純一朗; 松岡雅雄; 水上拓郎; 明里宏文

  第5回日本HTLV-1学会学術集会, 31 Aug. 2018, Peer-reviewed

  
• Development of humanized mouse models to evaluate and prevent mother-to-child HTLV-1 transmissions

  Takuo Mizukami; Kiyoko Nojima; Eita Sasaki; Yuki Hiradate; Keiko Furuhata; Yuko Sato; Sahoko Matsuoka; Kazu Okuma; Masahiro Satake; Hirofumi Akari; Kaoru Uchimaru; Isao Hamaguchi

  23rd Congress of European Hematology Association, 14 Jun. 2018, Peer-reviewed

  
• カニクイザルにおけるHIV‐1mt長期潜伏感染の解析

  関洋平; 齊藤暁; 佐藤賢文; 原田恵嘉; 吉村和久; 大出裕高; 岩谷靖雅; 石井洋; SAIFULISLAM M; 芳田剛; 村田めぐみ; 鷲崎彩夏; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文; 明里宏文

  日本エイズ学会誌, 20 Nov. 2017

  
• SIV感染サルをモデルとした中和抗体誘導メカニズムの解析

  桑田岳夫; 佐野雅人; 松岡佐織; 俣野哲朗; 関洋平; 明里宏文; 明里宏文; 三浦智行; 松下修三

  日本エイズ学会誌, 20 Nov. 2017

  
• Selective evolution of an anti-retroviral host factor TRIM5 in macaque monkeys.

  AKARI H

  2nd Kyoto International Symposium on Virus-Host Coevolution/Human-Nature Interplacement Life Science, Nov. 2017, Peer-reviewed

  
• Characterization of Long-term Latency of HIV-1mt Infection in Cynomolgus Macaques

  Seki Y; Saito A; Satou Y; Harada S; Yoshimura K; Ode H; Iwatani Y; Ishii H; Saiful IM; Yoshida T; Murata M; Washizaki A; Yasutomi Y; Matano T; Miura T; Akari H

  The 31th Annual Meeting of the Japanese Society for AIDS Research, Nov. 2017, Peer-reviewed

  
• A novel PKC activator 10-methyl-aplog-1 is a promising HIV-1 latency-reversing agent

  Washizaki A; Murata M; Seki Y; Tang YP; Kangawa H; Irie K; Akari H

  The 31th Annual Meeting of the Japanese Society for AIDS Research, Nov. 2017, Peer-reviewed

  
• Mechanism of neutralizing antibody induction in SIV-infected macaques

  Kuwata T; Sano M; Matsuoka S; Matano T; Seki Y; Akari H; Miura T; Matsushita S

  The 31th Annual Meeting of the Japanese Society for AIDS Research, Nov. 2017, Peer-reviewed

  
• Quantitative and qualitative evaluation of HIV-1 proviral DNA by digital droplet PCR and high-throughput sequencing

  Saiful IS; Miyazato P; Yohei Seki Y; Yang BTJ; Iwase S; Akari H; Satou Y

  The 31th Annual Meeting of the Japanese Society for AIDS Research, Nov. 2017, Peer-reviewed

  
• Development of HTLV-1 hyperimmune globulins against HTLV-1 infection

  Mizukami T; Nojima K; Sobata R; Murata M; Kuribayashi W; Matsumoto C; Sato Y; Washizaki A; Sasaki E; Seki Y; Furuhata K; Morimoto M; Hiradate Y; Matsuoka S; Natsume T; Ohkuma K; Uchimaru K; Akari H; Satake M; Hamaguchi I

  第79回日本血液学会学術集会, Oct. 2017, Peer-reviewed

  
• The transmission route of STLV-1 in Japanese macaques

  Murata M; Washizaki A; Seki Y; Yasunaga J; Matsuoka M; Akari H

  65th Annual Meeting of the Japanese Society for Virology, Oct. 2017, Peer-reviewed

  
• Absolute Quantitation of Integrated HIV-1 DNA In Vivo by using Droplet Digital PCR

  Saiful IS; Yohei Seki Y; Miyazato P; Yang BTJ; Akari H; Satou Y

  65th Annual Meeting of the Japanese Society for Virology, Oct. 2017, Peer-reviewed

  
• A novel PKC activator 10-methyl-aplog-1 is a promising HIV-1 latency-reversing agent

  Washizaki A; Murata M; Seki Y; Tang YP; Kangawa H; Irie K; Akari H

  65th Annual Meeting of the Japanese Society for Virology, Oct. 2017, Peer-reviewed

  
• Neutralizing antibody induction and changes in viral env sequences in the chronic phase of SIVsmH635FC infection

  Sano M; Kuwata T; Matsuoka S; Akari H; Miura T; Matano T

  65th Annual Meeting of the Japanese Society for Virology, Oct. 2017, Peer-reviewed

  
• Comparison of plasma neutralizing antibodies in two macaque-tropic HIV-1 infected macaques that were different response by CD8 depletion

  Shigeyoshi Harada; Yohei Seki; Yasuhiro Yasutomi; Tomoyuki Miura; Tetsuro Matano; Hirofumi Akari; Kazuhisa Yoshimura

  JOURNAL OF MEDICAL PRIMATOLOGY, Aug. 2017

  
• 閉経期雌ニホンザルの生殖器官におけるSTLV‐1感染動態の解析

  平舘裕希; 水上拓郎; 関洋平; 村田めぐみ; 鷲崎彩夏; 手塚健太; 鈴木樹理; 兼子明久; 石上暁代; 安永純一朗; 蔵田潔; 松岡雅雄; 明里宏文; 明里宏文; 浜口功

  日本獣医学会学術集会講演要旨集, Aug. 2017

  
• Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques

  Shigeyoshi Harada; Yuta Hikichi; Yohei Seki; Akatsuki Saito; Takeshi Yoshida; Hirotake Ode; Yasumasa Iwatani; Yasuhiro Yasutomi; Tomoyuki Miura; Tetsuro Matano; Hirofumi Akari; Kazuhisa Yoshimura

  35th Annual Symposium on Nonhuman Primate Models for AIDS, Aug. 2017, Peer-reviewed

  
• A novel PKC activator, 10-methyl-aplog-1 efficiently induces latently infected HIV-1 in combination with BET inhibitor JQ1

  Ayaka Washizaki; Megumi Murata; Yohei Seki; Yin Pui Tang; Kazuhiro Irie; Hirofumi Akari

  35th Annual Symposium on Nonhuman Primate Models for AIDS, Aug. 2017, Peer-reviewed

  
• 臨床応用を目指した抗HTLV‐1免疫グロブリン製剤の開発とニホンザルSTLV‐1母子感染動態の解析

  水上拓郎; 野島清子; 松本千恵子; 蕎麦田理英子; 村田めぐみ; 村田めぐみ; 平舘裕希; 鷲崎彩夏; 鷲崎彩夏; 関洋平; 関洋平; 森本真弓; 夏目尊好; 松岡佐保子; 大隈和; 内丸薫; 佐竹正博; 明里宏文; 明里宏文; 浜口功

  日本HTLV‐1学会学術集会, 2017

  
• 閉経期雌ニホンザルの生殖器官におけるSTLV‐1感染動態の解析

  平舘裕希; 水上拓郎; 関洋平; 村田めぐみ; 鷲崎彩夏; 手塚健太; 鈴木樹理; 兼子明久; 佐々木永太; 野島清子; 石上暁代; 安永純一朗; 蔵田潔; 松岡雅雄; 明里宏文; 明里宏文; 浜口功

  日本HTLV‐1学会学術集会, 2017

  
• HIV潜伏感染霊長類モデルの樹立及びリザーバー細胞の探索

  明里 宏文

  第30回日本エイズ学会学術集会, Nov. 2016, Peer-reviewed

  
• R5-tropic HIV-1 infection leads to long-term latency in cynomolgus macaques

  Hirofumi Akari; Yohei Seki; Akatsuki Saito; Yorifumi Satou; Shigeyoshi Harada; Kazuhisa Yoshimura; Hirotaka Ode; Yasumasa Iwatani; Takeshi Yoshida; Megumi Murata; Yuji Watanabe; Yasuhiro Yasutomi; Tetsuro Matano; Tomoyuki Miura

  第64回日本ウイルス学会学術集会, Oct. 2016, Peer-reviewed

  
• STLV−１自然感染ニホンザルに関するCohort研究：高感染率の機序

  村田めぐみ; 安永純一朗; 関洋平; 松岡雅雄; 明里宏文

  第64回日本ウイルス学会学術集会, Oct. 2016, Peer-reviewed

  
• Long-term Latency of HIV-1mt Infection in Cynomolgus Macaques is Reserved in Follicular Helper T Lymphocytes

  Yohei Seki; Akatsuki Saito; Yorifumi Satou; Shigeyoshi Harada; Hirotaka Ode; Hiroshi Ishii; Takeshi Yoshida; Megumi Murata; Hiroyuki Kangawa; Yuji Watanabe; Yasumasa Iwatani; Kazuhisa Yoshimura; Yasuhiro Yasutomi; Tomoyuki Miura; Tetsuro Matano; Hirofumi Akari

  34th Annual Symposium on Nonhuman Primate Models for AIDS, Oct. 2016, Peer-reviewed

  
• 臨床応用を目指した抗HTLV-1ヒト免疫グロブリンによるHTLV-1感染予防法の開発と安全性に関する研究

  水上拓郎; 野島清子; 松本千恵子; 栗林和華子; 蕎麦田理英子; 佐々木永太; 平舘裕希; 倉光球; 古畑啓子; 村田めぐみ; 松岡佐保子; 大隈和; 佐竹正博; 明里宏文; 内丸薫; 浜口功

  第３回HTLV-1学会学術集会, Aug. 2016, Peer-reviewed

  
• Structural FEATURES OF THE APOBEC3H REGION CRITICAL FOR HIV-1 VIF INTERACTION

  Masaaki Nakashima; Shinya Tsuzuki; Hiroaki Awazu; Hirotaka Ode; Masami Maejima; Atsuko Hachiya; Yoshiyuki Yokomaku; Nobuhisa Watanabe; Hirofumi Akari; Yasumasa Iwatani

  Cold Spring Harbor meeting on Retroviruses, May 2016, Peer-reviewed

  
• 血液系細胞におけるHTLV‐1感染とその意義

  古田梨愛; 安永純一朗; 三浦未知; 菅田謙治; 齊藤暁; 明里宏文; 上野孝治; 竹之内徳博; 藤澤順一; 清水正和; 松田文彦; ANAT Melamed; BANGHAM Charles; 松岡雅雄

  日本HTLV‐1学会学術集会, 2016

  
• 培養細胞由来C型肝炎ウイルス粒子ワクチンは非ヒト霊長類モデルにて感染中和抗体を誘導する

  横川 寛; 東濃 篤徳; 鈴木 沙織; 鈴木 知比古; 明里 宏文; 加藤 孝宣; 石井 孝司; 脇田 隆字

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Hypnotic effects and pharmacokinetics of a single bolus dose of alfaxalone in Japanese macaques (Macaca fuscata)

  T. Miyabe-Nishiwaki; A. Kaneko; N. Suda-Hashimoto; Y. Indo; A. Ishigami; S. Aisu; A. Yamanaka; K. Nakamura; H. Akari; M. Okamoto; T. Fukui; K. Masui

  12th World Congress of Veterinary Anaesthesiology, Sep. 2015

  
• 持続感染した霊長類肝炎ウイルスの適応変異:ウイルスゲノム変異が及ぼす病態への影響

  東濃篤徳; 鈴木紗織; 森健一; 大出裕高; 松岡和弘; 片貝祐子; 岡林佐知; 槇昇; 岩谷靖雅; 杉浦亙; 明里宏文

  霊長類研究, 20 Jun. 2015

  
• 新型センダイウイルスを用いたチンパンジー血液由来iPS細胞の作製

  藤江康光; 房木ノエミ; 片山朋彦; 濱崎誠; 副島由美; 曽我美南; 伴浩志; 長谷川譲; 山下賢; 木村重美; 鈴木沙織; 松沢哲郎; 明里宏文; 江良択実

  再生医療, 01 Feb. 2015

  
• サル指向性HIV-1のin vivoにおける増殖効率を上昇させる要因

  関洋平; 芳田剛; 齊藤暁; 松岡和弘; 大出裕高; 岩谷靖雅; 保富康宏; 俣野哲朗; 三浦智行; 杉浦亙; 明里宏文

  第62回日本実験動物学会, 2015, Peer-reviewed

  
• HCVベースのHCV/GBV-Bキメラウイルスはタマリンへ長期感染する

  鈴木紗織; 東濃篤徳; 森健一; 片貝祐子; 槇昇; 明里宏文

  第62回日本実験動物学会学術集会, 2015, Peer-reviewed

  
• 小型霊長類において持続感染したヘパチウイルスゲノムの経時的変異

  東濃篤徳; 鈴木紗織; 森健一; 大出裕高; 松岡和弘; 片貝祐子; 岡林佐知; 槇昇; 岩谷靖雅; 杉浦亙; 明里宏文

  第62回日本実験動物学会学術集会, 2015, Peer-reviewed

  
• Low humoral immune responses in New World Monkeys are associated with the persistent infection of primate hepatitis virus

  Suzuki Saori; Higashino Atsunori; Mori Ken-ichi; Ode Hirotaka; Matsuoka Kazuhiro; Iwatani Yasumasa; Sugiura Wataru; Katakai Yuko; Maki Noboru; Akari Hirofumi

  Primate Research Supplement, 2015, Peer-reviewed

  
• Genetic and immunological escape in persistent GBV-B infection

  Saori Suzuki; Atsunori Higashino; Ken-ichi Mori; Hirotaka Ode; Kazuhiro Matsuoka; Yasumasa Iwatani; Wataru Sugiura; Yuko Katakai; Noboru Maki; Hirofumi Akari

  22nd International Symposium on Hepatitis C Virus and Related Viruses, 2015, Peer-reviewed

  
• Novel elite controller model by HIV-1mt-infected cynomolgus macaques

  Yohei Seki; Akatsuki Saito; Takeshi Yoshida; Yorifumi Satou; Shigeyoshi Harada; Kazuhisa Yoshimura; Yuji Watanabe; Yasumasa Iwatani; Yasuhiro Yasutomi; Tetsuro Matano; Tomoyuki Miura; Hirofumi Akari

  33rd Annual Symposium on NHP Models for AIDS, 2015, Peer-reviewed

  
• Detection of potency and breadth of HIV-1 Neutralizing Antibodies in macaque-tropic HIV-1 infected cynomolgus monkeys using novel test panel viruses

  Shigeyoshi Harada; Akatsuki Saito; Takeshi Yoshida; Yohei Seki; Yuji Watanabe; Yasumasa Iwatani; Yasuhiro Yasutomi; Tomoyuki Miura; Tetsuro Matano; Hirofumi Akari; Kazuhisa Yoshimura

  33rd Annual Symposium on NHP Models for AIDS, 2015, Peer-reviewed

  
• HIV-1mt感染カニクイザルによる新規エリートコントローラーモデル

  関洋平; 齊藤暁; 芳田剛; 佐藤賢文; 原田恵嘉; 吉村和久; 渡部祐司; 岩谷靖雅; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第63回日本ウイルス学会学術集会, 2015, Peer-reviewed

  
• 高病原性HIV感染サルにおいてウイルス感染CD163陽性マクロファージは様々な半減期を持つ集団から構成され、最も半減期の長い集団は多剤併用療法下のリザーバーと成り得る

  渡部祐司; 岩見真吾; 森ひろみ; 松浦嘉奈子; 日紫喜隆行; 三浦智行; 明里宏文; 五十嵐樹彦

  第63回日本ウイルス学会学術集会, 2015, Peer-reviewed

  
• 慢性GBV-B感染におけるenvelope変異および液性免疫からの逃避

  鈴木紗織; 東濃篤徳; 森健一; 大出裕高; 松岡和弘; 岩谷靖雅; 杉浦亙; 片貝祐子; 槇昇; 明里宏文

  第63回日本ウイルス学会学術集会, 2015, Peer-reviewed

  
• 霊長類ヘパチウイルス慢性感染後寛解におけるウイルスゲノム変異の意義

  東濃篤徳; 鈴木紗織; 大出裕高; 松岡和弘; 森健一; 片貝祐子; 岡林佐知; 槇昇; 岩谷靖雅; 杉浦亙; 明里宏文

  第63回日本ウイルス学会学術集会, 2015, Peer-reviewed

  
• R5指向性HIV-1mt感染カニクイザルによる新規エリートコントローラーモデルの開発

  関洋平; 芳田剛; 齊藤暁; 佐藤賢文; 原田恵嘉; 吉村和久; 渡部祐司; 岩谷靖雅; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第29回日本エイズ学会学術集会, 2015, Peer-reviewed

  
• 高病原性SHIV感染サルにおいて、ART治療下で観察されたウイルスの減衰に関する検証

  渡部祐司; 岩見真吾; 森ひろみ; 松浦嘉奈子; 日紫喜隆行; 三浦智行; 明里宏文; 五十嵐樹彦

  第29回日本エイズ学会学術集会, 2015, Peer-reviewed

  
• Anti‐CCR4抗体はTregと感染細胞を同時に標的にする事で,STLV‐1自然感染ニホンザルでのウイルス特異的免疫反応を活性化させる

  SUGATA KENJI; YASUNAGA JUN'ICHIRO; MIURA MICHI; AKARI HIROFUMI; KOYANAGI YOSHIO; KOHARA MICHINORI; MATSUOKA MASAO

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014

  
• 培養細胞由来HCV粒子のマーモセットにおける抗HCV抗体誘導能の検討

  横川寛; 中村紀子; 東濃篤徳; 鈴木紗織; 明里宏文; 加藤孝宣; 石井孝司; 脇田隆字

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014

  
• サルレトロウイルス4型プロウイルス陽性非発症ニホンザルの解析

  SATO EIJI; KANEKO AKIHISA; SAITO SATORU; YAMANAKA ATSUSHI; SUZUKI JURI; WATANABE AKINO; YOSHIDA TOMONORI; YOSHIKAWA ROKUSUKE; MIYAZAWA TAKAYUKI; AKARI HIROFUMI; OKAMOTO MUNEHIRO

  日本獣医学会学術集会講演要旨集, 11 Aug. 2014

  
• 霊長類におけるULBP/RAET1遺伝子群の進化と特徴

  成瀬妙子; 飯塚淳次; 明里宏文; 俣野哲朗; 木村彰方

  日本組織適合性学会大会抄録集, 2014

  
• 霊長類におけるULBP5/RAET1-G遺伝子群の進化

  成瀬妙子; 飯塚淳次; 明里宏文; 俣野哲朗; 木村彰方

  日本遺伝子診療学会大会プログラム・抄録集, 2014

  
• 培養細胞由来C型肝炎ウイルス粒子のマーモセットにおけるワクチン効果の検討

  横川寛; 中村紀子; 東濃篤徳; 鈴木沙織; 明里宏文; 加藤孝宣; 石井孝司; 脇田隆字

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• GBV-B感染マーモセット/タマリンにおける慢性化移行には液性免疫応答の遅延が関与する

  鈴木紗織; 東濃篤徳; 森健一; 片貝祐子; 齊藤暁; 槇昇; 明里宏文

  第61回日本実験動物学会総会, 2014, Peer-reviewed

  
• 小型霊長類モデルを用いたヘパチウイルスの持続感染における慢性肝炎発症に影響するウイルスゲノム変異解析

  東濃篤徳; 鈴木紗織; 齊藤暁; 松岡和弘; 大出裕高; 片貝祐子; 岡林佐知; 森健一; 槇昇; 明里宏文

  第61回日本実験動物学会総会, 2014, Peer-reviewed

  
• 小型霊長類において持続感染したGBV-Bの変異解析

  東濃篤徳; 鈴木紗織; 森健一; 大出裕高; 松岡和弘; 片貝祐子; 岡林佐知; 槇昇; 岩谷靖雅; 杉浦亙; 明里宏文

  第62回日本ウイルス学会学術集会, 2014, Peer-reviewed

  
• サル個体におけるサル指向性HIV-1の増殖効率を上昇させる要因

  芳田剛; 齊藤暁; 松岡和弘; 大出裕高; 岩谷靖雅; 杉浦亙; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第62回日本ウイルス学会学術集会, 2014, Peer-reviewed

  
• サル指向性HIV-1の感染個体における増殖効率を上昇させる要因

  芳田剛; 齊藤暁; 松岡和弘; 大出裕高; 岩谷靖雅; 保富康宏; 俣野哲朗; 三浦智行; 杉浦亙; 明里宏文

  第28回日本エイズ学会学術集会, 2014, Peer-reviewed

  
• 組換えウイルスを用いた抗HTLV‐1ワクチンの作製とMacaque属での応用

  KANDA KENJI; YASUNAGA JUN'ICHIRO; MIURA MICHI; AKARI HIROFUMI; KOYANAGI YOSHIO; KOHARA MICHINORI; MATSUOKA MASAO

  日本ウイルス学会学術集会プログラム・抄録集, 29 Oct. 2013

  
• GBV‐B感染における慢性化移行には液性免疫応答の遅延が関与する

  鈴木紗織; 東濃篤徳; 森健一; 吉田友教; 片貝祐子; 齊藤暁; 槇昇; 明里宏文

  日本ウイルス学会学術集会プログラム・抄録集, 29 Oct. 2013

  
• 霊長類モデルを用いた培養細胞由来HCV粒子ワクチンの有効性の検討

  横川寛; 森山正樹; 中村紀子; 東濃篤徳; 明里宏文; 加藤孝宣; 石井孝司; 脇田隆字

  日本ウイルス学会学術集会プログラム・抄録集, 29 Oct. 2013

  
• 旧世界ザルにおけるULBP2/RAET1H遺伝子の種特異的多様性

  成瀬妙子; 森一泰; 明里宏文; 俣野哲朗; 木村彰方

  日本組織適合性学会大会抄録集, 2013

  
• 旧世界ザルULBP2/RAET1H遺伝子の種特異的多様性

  成瀬妙子; 森一泰; 明里宏文; 俣野哲朗; 木村彰方

  日本人類遺伝学会大会プログラム・抄録集, 2013

  
• アカゲザルを用いた培養細胞由来HCV粒子ワクチンの抗体誘導能と安全性の検討

  横川寛; 森山正樹; 中村紀子; 東濃篤徳; 明里宏文; 加藤孝宣; 石井孝司; 脇田隆字

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• 感染性分子クローン由来ウイルスを用いたニホンザル血小板減少症の病態解析

  坂口翔一; 吉川禄助; 岡本宗裕; 明里宏文; 齊藤暁; 佐藤英次; 安永純一郎; 三浦智行; 宮沢孝幸

  日本野生動物医学会大会・講演要旨集, 2013

  
• 霊長類を用いたHCV/ GBV-Bキメラウイルス感染モデル

  東濃篤徳; 森健一; 鈴木紗織; 岩崎優紀; 吉田友教; 齊藤暁; 槇昇; 明里宏文

  第６０回日本実験動物学会総会, 2013, Peer-reviewed

  
• レトロウイルス感受性に影響するマカク属サルTRIM5遺伝子の多様性

  齊藤暁; 中山英美; 塩田達雄; 吉田友教; 東濃篤徳; 鈴木紗織; 川本芳; 明里宏文

  第６０回日本実験動物学会総会, 2013, Peer-reviewed

  
• GBV-B感染新世界ザルの液性免疫解析

  鈴木紗織; 東濃篤徳; 森健一; 吉田友教; 齊藤暁; 槇昇; 明里宏文

  第６０回日本実験動物学会総会, 2013, Peer-reviewed

  
• Diversity of antiretroviral host factor TRIM5 gene in macaque monkeys

  Akatsuki Saito; Emi E Nakayama; Tatsuo Shioda; Tomoyuki Yoshida; Atsunori Higashino; Saori Suzuki; Yoshi Kawamoto; Hirofumi Akari

  Cold Spring Harbor meeting on Retroviruses, 2013, Peer-reviewed

  
• SRV-4

  鈴木樹理; 明里宏文; 岡本宗裕; 吉田友教; 森本真弓; 宮沢孝幸; 吉川禄助

  サル疾病ワークショップ, 2013, Peer-reviewed

  
• 京都大学霊長類研究所サル施設でサルレトロウイルス４型に感染したニホンザル由来感染性分子クローンを用いた感染実験

  坂口翔一; 吉川禄助; 岡本宗裕; 明里宏文; 齊藤暁; 佐藤英次; 安永純一郎; 三浦智行; 宮沢孝幸

  第１９回日本野生動物学会大会, 2013, Peer-reviewed

  
• ウイルスの標的細胞指向性はサル指向性HIV-1の増殖に影響するか？

  齊藤暁; 大附寛幸; 東濃篤徳; 鈴木紗織; 松田健太; 高橋尚史; 岩谷靖雅; 杉浦亙; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第156回日本獣医学会学術集会, 2013, Peer-reviewed

  
• ニホンザルにおけるサルレトロウイルス４型の臓器特異性の調査

  佐藤英次; 鈴木樹理; 渡邉朗野; 兼子明久; 吉川禄助; 吉田友教; 山中淳史; 齊藤暁; 齊藤波子; 明里宏文; 宮沢孝幸; 岡本宗裕

  第156回日本獣医学会学術集会, 2013, Peer-reviewed

  
• Analysis of dynamics in GB virus B quasispecies in the course of long-term persistent infection and disease progression in marmosets

  Atsunori Higashino; Saori Suzuki; Akatsuki Saito; Yuko Katakai; Sachi Okabayashi; Hirofumi Akari

  20th International Symposium on Hepatitis C Virus and Related Viruses, 2013, Peer-reviewed

  
• The delayed humoral immune responses may be associated with the development of chronic GBV-B infection

  Saori Suzuki; Atsunori Higashino; Ken-ichi Mori; Yuko Katakai; Akatsuki Saito; Noboru Maki; Hirofumi Akari

  20th International Symposium on Hepatitis C Virus and Related Viruses, 2013, Peer-reviewed

  
• サルレトロウイルス４型持続感染ニホンザルにおける免疫学的役割の解明

  佐藤英次; 兼子明久; 齊藤暁; 山中淳史; 鈴木樹理; 渡邉朗野; 吉田友教; 吉川禄助; 齊藤波子; 牧野_恵美子; 道家由美子; 塩澤裕子; 安江美雪; 森本真弓; 宮沢孝幸; 明里宏文; 岡本宗裕

  第６１回日本ウイルス学会学術集会, 2013, Peer-reviewed

  
• 新世界ザルにおける持続感染GBV-BのQuasispecies解析

  東濃篤徳; 鈴木紗織; 齊藤暁; 片貝祐子; 岡林佐知; 明里宏文

  第６１回日本ウイルス学会学術集会, 2013, Peer-reviewed

  
• Development of a novel non-human primate model for secondary dengue virus infection using marmosets

  Moi ML; Omatsu T; Nakamura S; Ami Y; Katakai Y; Suzaki Y; Saijo M; Akari H; Kurane I; Takasaki T

  第６１回日本ウイルス学会学術集会, 2013, Peer-reviewed

  
• 急性及び慢性GBV-B感染症における液性免疫の比較解析

  鈴木紗織; 東濃篤徳; 森健一; 吉田友教; 片貝祐子; 齊藤暁; 槇昇; 明里宏文

  第６１回日本ウイルス学会学術集会, 2013, Peer-reviewed

  
• CCR5指向性を示す新規サル指向性HIV-1はサル個体に持続感染する

  齊藤暁; 大附寛幸; 東濃篤徳; 鈴木紗織; 松田健太; 高橋尚史; 松岡佐織; 岩谷靖雅; 杉浦亙; 野間口雅子; 足立昭夫; 保富康宏; 俣野哲朗; 三浦智行; 明里宏文

  第６１回日本ウイルス学会学術集会, 2013, Peer-reviewed

  
• タマリンを用いたHCV/GBV‐Bキメラウイルス感染モデル

  東濃篤徳; 森健一; 鈴木紗織; 岩崎優紀; 吉田友教; 齊藤暁; 槇昇; 明里宏文

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2012, Peer-reviewed

  
• EVOLUTIONAL MEDICINE IS AN APPROACH TO IDENTIFY THE HUMAN GENOME DIVERSITY ASSOCIATED WITH HIV/AIDS

  Akinori Kimura; Hitoshi Ohtani; Taeko Naruse; Toshiaki Nakajima; Kazuyasu Mori; Hirofumi Akari; Tetsuro Matano; Gaurav Sharma; Gurvinder Kaur; Narinder K. Mehra

  TISSUE ANTIGENS, Jun. 2012

  
• POLYMORPHISMS IN TWO OF ULBP2/RAET1H GENES IN THE OLD WOLD MONKEY

  Taeko Naruse; Kazuyasu Mori; Hirofumi Akari; Akinori Kimura

  TISSUE ANTIGENS, Jun. 2012

  
• 大型類人猿における糞便サンプルを用いた人獣共通感染症の抗体スクリーニング方法の開発

  吉田友教; 宮部貴子; 郡山尚紀; 竹本博幸; 生駒智子; 渡邉朗野; 兼子明久; 渡邉祥平; 斎藤暁; 早川敏之; 鈴木樹理; 岡本宗裕; 松沢哲郎; 古市剛史; 明里宏文

  第２８回日本霊長類学会 (2012/7 名古屋）, 2012

  
• アフリカ野生大型類人猿におけるIgA抗体スクリーニングによる人獣共通感染症の実態調査

  吉田友教; 竹本博幸; 佐藤英次; 坂巻哲也; 宮部貴子; 生駒智子; 渡邉朗野; 兼子明久; 渡邉祥平; 早川敏之; 鈴木樹理; 岡本宗裕; 松沢哲郎; 明里宏文; 古市剛史

  第５９回日本実験動物学会総会 (2012/5/24-26 別府）, 2012

  
• サルT 細胞白血病ウイルス1 型のウイルス学的解析と病原性

  三浦未知; 田邉順子; 菅田謙治; Zhao Tiejun; 齊藤暁; 安永純一朗; 明里宏文; 松岡雅雄

  第60 回日本ウイルス学会学術集会、プランキューブ大阪(大阪) 、2012 年11 月13-15, 2012, Peer-reviewed

  
• 大型類人猿における人獣共通感染症の抗体スクリーニング方法の開発

  吉田友教; 宮部貴子; 郡山尚紀; 竹元博幸; 生駒智子; 渡邉朗野; 兼子明久; 渡邉祥平; 齊藤暁; 早川敏之; 鈴木樹理; 岡本宗裕; 松沢哲郎; 古市剛史; 明里宏文

  第59回日本実験動物学会総会(2012/05/24-26, 別府), 2012, Peer-reviewed

  
• レトロウイルス感受性を規定するカニクイザルTRIM5遺伝子型の地理的多様性

  齊藤暁; 河野健; 中山英美; 日柳章彦; 保富康宏; 塩田達雄; 吉田友教; 東濃篤徳; 生駒智子; 川本芳; 鳥居隆三; 明里宏文

  第59回日本実験動物学会総会(2012/05/24-26), 2012, Peer-reviewed

  
• アジアに生息するマカク属サルで認められるTRIM5遺伝子の多様性

  齊藤暁; 河野健; 中山英美; 保富康宏; 塩田達雄; 吉田友教; 東濃篤徳; 川本芳; 鳥居隆三; 明里宏文

  第26回日本エイズ学会学術集会・総会 (2012/11, 神奈川), 2012, Peer-reviewed

  
• ヒト免疫不全ウイルスによる MHC-1 発現制御機構の分子構造学的解析

  明里宏文

  第 21 回日本組織適合性学会大会シンポジウム, 東京, 2012, Peer-reviewed

  
• カニクイザルTRIM5遺伝子アリルの地理的多様性とその機能的意義

  齊藤暁; 河野健; 中山英美; 日柳章彦; 足立昭夫; 野間口雅子; 保富康宏; 俣野哲朗; 塩田達雄; 吉田友教; 東濃篤徳; 生駒智子; 川本芳; 鳥居隆三; 明里宏文

  第153回日本獣医学会学術集会 (2012/03/27-29, 大宮), 2012, Peer-reviewed

  
• ニホンザル血小板減少症の原因ウイルスの探索

  吉川禄助; 佐藤英次; 岡本宗裕; 鈴木樹理; 吉田友教; 明里宏文; 三浦智行; 宮沢孝幸

  第153 回日本獣医学会学術集会, 埼玉, 2012 年3 月27-29 日, 2012, Peer-reviewed

  
• An animal model for chimeric virus of hepatitis C virus/GB virus B

  Higashino A; Mori K; Suzuki S; Iwasaki Y; Yoshida T; Saito A; Maki N; Akari H

  19th International Symposium on Hepatitis C Virus and Related Viruses (2012/10/05-09, Venice), 2012, Peer-reviewed

  
• Thrombocytopenia caused by SRV-4 in Japanese macaques (Macaca fuscata).

  Suzuki J; Akari H; Okamoto M; Yoshida T; Okabayashi S

  Satellite Symposium of the 5th Annual Meeting of the ASZWM(2012/10/14, Chiang Mai)., 2012, Peer-reviewed

  
• SRV-4の関与が疑われる血小板減少症

  鈴木樹理; 明里宏文; 岡本宗裕; 吉田友教; 岡林佐知

  第20回サル疾病ワークショップ (2011/07/02, 麻布大学（神奈川県）), 02 Jul. 2011, Peer-reviewed

  
• 京大霊長研で見られたニホンザル血小板減少症（１）：概要報告

  明里宏文; 鈴木樹理; 岡本宗裕; 宮部貴子; 渡邉朗野; 兼子明久; 熊崎清則; 阿部政光; 釜中慶朗; 前田典彦; 森本真弓; 渡邉祥平; 須田直子; 平井啓久; 松沢哲郎

  第５８回日本実験動物学会(2011/5 東京）, 2011

  
• Simian retrovirus-4-associated infectious thrombocytopenia in Japanese macaques.

  Yoshida T; Okamoto M; Akari H; Suzuki J; Miyabe-Nishiwaki T; Hayakawa T; Imai H; Matsui A; Watanebe A; Kaneko A; Hirai H

  The Unlimited World Microbes International Union of Microbiological Societies 2011 Congress XV International Congress of Virology. (2011/09, Sapporo, Japan)., 2011, Peer-reviewed

  
• Genotypic variation of cynomolgus monkey TRIM5α determines the susceptibility to monkey-tropic HIV-1 infection

  Akatsuki Saito; Masako Nomaguchi; Ken Kono; Emi E. Nakayama; Tatsuo Shioda; Yasuhiro Yasutomi; Akio Adachi; Tetsuro Matano; Hirofumi Akari

  IUMS2011, 2011, Peer-reviewed

  
• ニホンザル血小板減少症の発生に関する経過概要

  明里宏文; 鈴木樹理; 岡本宗裕; 宮部貴子; 渡邉朗野; 兼子明久; 阿部政光; 釜中慶朗; 前田典彦; 森本真弓; 渡邉祥平; 須田直子; 平井啓久; 松沢哲郎

  第152回日本獣医学会大会 (2011/10, 堺，大阪), 2011, Peer-reviewed

  
• サル指向性HIV-1への感受性に影響を与えるマカクサルTRIM5遺伝子の多様性

  齊藤暁; 河野健; 中山英美; 足立昭夫; 野間口雅子; 保富康宏; 俣野哲朗; 塩田達雄; 明里宏文

  第25回日本エイズ学会学術集会 (2011/11/30-12/2, 東京), 2011, Peer-reviewed

  
• ル指向性HIV-1感染慢性潜伏期のカニクイサルからの感染性ウイルスの回収

  高橋尚史; 齊藤暁; 野間口雅子; 松岡佐織; 足立昭夫; 明里宏文; 俣野哲朗

  第25回日本エイズ学会学術集会 (2011/11/30-12/2, 東京), 2011, Peer-reviewed

  
• 京大霊長研で見られたニホンザル血小板減少症(4)：疫学調査

  吉田友教; 岡本宗裕; 明里宏文; 今井啓雄; 松井淳; 早川敏之; 生駒智子; 伯川美穂; 齋藤波子; 渡邉朗野; 兼子明久; 宮部貴子; 鈴木樹理; 平井啓久

  第58回日本実験動物学会 (2011/05, 東京), 2011, Peer-reviewed

  
• SHRNA-MEDIATED GENE SILENCING IN NON-HUMAN PRIMATES WITH AAV8

  Takayuki Kubodera; Shinga Ohira; Yuko Katakai; Hirofumi Akari; Yukihiko Hirai; Hiroaki Mizukami; Keiya Ozawa; Takashi Shimada; Hidehiro Mizusawa; Takanori Yokota

  JOURNAL OF GENE MEDICINE, Dec. 2010

  
• ヒトおよびアカゲザルにおけるRAET1/ULBP遺伝子群の多様性

  成瀬妙子; 奥田裕紀子; 俣野哲朗; 明里宏文; 森一泰; 保富康宏; 宮澤正顕; 木村彰方

  日本人類遺伝学会大会プログラム・抄録集, 2010

  
• カニクイザルTRIM5 alleleがサル指向性HIV-1の増殖に与えるインパクト

  齊藤暁; 河野健; 中山英美; 塩田達雄; 足立昭夫; 野間口雅子; 保富康宏; 俣野哲朗; 明里宏文

  第24回日本エイズ学会学術集会・総会, 2010, Peer-reviewed

  
• カニクイザルにおける第3世代サル指向性HIV-1の増殖の解析

  齊藤暁; 河野健; 黒石歩; 中山英美; 塩田達雄; 足立昭夫; 野間口雅子; 保富康宏; 俣野哲朗; 明里宏文

  第24回日本エイズ学会学術集会・総会, 2010, Peer-reviewed

  
• C型肝炎とHIV感染症（AIDS）

  明里宏文

  第57回日本実験動物学会学術集会シンポジウム（京都）2010/5/12?14, 2010, Peer-reviewed

  
• C型肝炎の新規霊長類モデル開発

  明里宏文

  第47回日本ウイルス学会九州支部総会（宮崎）2010/9/3‐4., 2010, Peer-reviewed

  
• HIV-1感染霊長類モデルの開発

  明里宏文

  第58回日本ウイルス学会学術集会シンポジウム（徳島）2010/11/7‐9, 2010, Peer-reviewed

  
• HCV, HIVの新規霊長類モデル開発

  明里宏文

  大阪大学微生物病研究所セミナー（大阪）2010/8/26., 2010, Peer-reviewed

  
• Novel non-human primate models for hepatitis C and AIDS

  Hirofumi Akari

  2010 KALAS international symposium (Korea, Busan) August 19-21, 2010, 2010, Peer-reviewed

  
• SIV由来CA h6/7 loopを持つ第2世代サル指向性HIV-1クローンはカニクイザル個体で効率よく増殖する

  齊藤暁; 飯島沙幸; 岩崎優紀; 黒石歩; 中山英美; 塩田達雄; 足立昭夫; 野間口雅子; 俣野哲朗; 明里宏文

  第57回日本ウイルス学会学術集会, 2009, Peer-reviewed

  
• 第2世代サル指向性HIV-1クローンはカニクイザル個体において効率良く増殖する

  齊藤暁; 飯島沙幸; 岩崎優紀; 明里宏文

  第148回日本獣医学会学術集会, 2009, Peer-reviewed

  
• 肝炎ウイルスワクチン実用化のための基盤的研究 ワクチン評価のための霊長類C型肝炎サロゲートモデル開発の基盤研究

  明里宏文; 岩崎優紀; 飯島沙幸; 木村展之; 揚山直英; 石井孝司; 吉崎佐矢香; 鈴木哲朗; 宮村達男; 槇昇, 森健一

  肝炎ウイルスワクチン実用化のための基盤的研究 平成20年度 総括・分担研究報告書, 2009

  
• ウイルスと霊長類：共生のためのウイルス戦略

  明里宏文

  人獣共通感染症セミナー 宮崎大学, 2009, Peer-reviewed

  
• Selective and frequent non-synonymous mutations of the viral genome in chronically GBV-B-infected marmosets.

  Yoshida T; Iwasaki Y; Mori K; Maki N; Ishii K; Iijima S; Yoshizaki S; Katakai Y; Suzuki T; Miyamura T; Akari H

  16th International Symposium on Hepatitis C Virus and Related Viruses (2009/10/03-07, France, Nice)., 2009, Peer-reviewed

  
• Gag特異的CTLクローンのSIV複製抑制能の解析 (学会抄録)

  石井洋; 塚本徹雄; 川田真幹; 武内寛明; 明里宏文; 上野貴将; 滝口雅文; 俣野哲朗

  日本エイズ学会誌, Nov. 2008, Peer-reviewed

  
• 新規HIV-1/サルモデルの開発；新規HIV-1クローンNL-DT5Rはカニクイザル個体内で増殖する

  齊藤暁; 飯島沙幸; 岩崎優紀; 海津雅彦; 足立昭夫; 野間口雅子; 俣野哲朗; 明里宏文

  第56回日本ウイルス学会学術集会, Oct. 2008, Peer-reviewed

  
• マカクザル感染性新規HIV-1クローンの解析

  齊藤暁; 飯島沙幸; 岩崎優紀; 海津雅彦; 明里宏文

  第146回日本獣医学会学術集会, 2008, Peer-reviewed

  
• C型肝炎の治療とキャリアからの発症予防に関する基礎研究 サルを用いたC型肝炎サロゲートモデル開発に関する研究

  明里宏文; 岩崎優紀; 飯島沙幸; 木村展之; 揚山直英; 石井孝司; 吉崎佐矢香; 鈴木哲朗; 宮村達男; 槇昇, 森健一

  C型肝炎の治療とキャリアからの発症予防に関する基礎研究 平成19年度 総括・分担研究報告書, 2008

  
• 輸入リスザルおよびタマリンで高率に検出されるTrypanosoma minasense感染,並びに本種の分子系統学的位置づけ

  佐藤宏; 片貝裕子; 高野淳一朗; 明里宏文; 中村進一; 宇根有美

  日本寄生虫学会大会プログラム・抄録集, 23 Feb. 2007

  
• ゲノム創薬およびゲノム医療技術の開発・臨床応用に資する画期的な霊長類研究リソースの開発研究 C型肝炎モデルの有用性評価指標の開発

  明里宏文; 飯島沙幸; 木村展之; 揚山直英; 岩崎優紀; 石井孝司; 吉崎佐矢香; 鈴木哲朗; 宮村達男; 槇昇, 森健一

  ゲノム創薬およびゲノム医療技術の開発・臨床応用に資する画期的な霊長類研究リソースの開発研究 平成18年度 総括・分担研究報告書, 2007

  
• C型肝炎の治療とキャリアからの発症予防に関する基礎研究 サルを用いたC型肝炎サロゲートモデル開発に関する研究

  明里宏文; 岩崎優紀; 飯島沙幸; 木村展之; 揚山直英; 石井孝司; 吉崎佐矢香; 鈴木哲朗; 宮村達男; 槇昇, 森健一

  C型肝炎の治療とキャリアからの発症予防に関する基礎研究 平成18年度 総括・分担研究報告書, 2007

  
• C型肝炎の治療とキャリアからの発症予防に関する基礎研究 サルを用いたC型肝炎サロゲートモデル開発に関する研究

  明里宏文; 飯島沙幸; 木村展之; 揚山直英; 李永仲; 石井孝司; 吉崎佐矢香; 鈴木哲朗; 宮村達男; 八木慎太郎; 山口健次郎; 槙昇

  C型肝炎の治療とキャリアからの発症予防に関する基礎研究 平成17年度 総括・分担研究報告書, 2006

  
• カニクイザルにおけるMHC class Iの解析

  宇田 晶彦; 棚林 清; 寺尾 恵治; 明里 宏文; 向井 鐐三郎; 山田 章雄

  日本獣医学会学術集会講演要旨集, Mar. 2004

  
• Nef蛋白によるHLA‐ClassI分子の発現低下がHIV‐1特異的CD8T細胞の抗原認識に与える影響

  冨山宏子; 明里宏文; 足立昭夫; 滝口雅文

  日本エイズ学会誌, 20 Nov. 2001

  
• Expression of cytokine in the SIV experimentally infected monkey encephalitis lesion. (Ministry of Health and Welfare S ).

  佐多徹太郎; 喜納奈緒; 巽正志; 小野文子; 大谷功; 明里宏文; 吉川泰弘; 岩崎琢也; 倉田毅

  エイズ動物モデルを利用した疾病に関する研究 平成8年度 研究成果報告書, 1997

  
• Evaluation on anti-AIDS medicine using the AIDS monkey model and the research on future prospect. ( Ministry of Health and Welfare S ).

  吉川泰弘; 向井りょう三郎; 大谷功; 森一泰; 村山裕一; 明里宏文; 高阪精夫; 佐多徹太郎; 小野文子

  エイズ動物モデルを利用した疾病に関する研究 平成8年度 研究成果報告書, 1997

  
• Pathology of SIV experimentally infected monkey encephalitis. ( Ministry of Health and Welfare S ).

  佐多徹太郎; 向井りょう三郎; 小野文子; 大谷功; 明里宏文; 森一泰; 吉川泰弘; 倉田毅

  エイズ動物モデルを利用した疾病に関する研究 平成7年度 研究成果報告書, 1996

  
• Research on the evaluation of anti-AIDS medicine using the AIDS infected monkey . ( Ministry of Health and Welfare S ).

  吉川泰弘; 向井りょう三郎; 森一泰; 村山裕一; 明里宏文; 大谷功; 高阪精夫; 佐多徹太郎; 小野文子

  エイズ動物モデルを利用した疾病に関する研究 平成7年度 研究成果報告書, 1996

  
• Pathology in monkey contracted to SIV and taken encephalitis. (Ministry of Health and Welfare S)

  佐多徹太郎; 向井りょう三郎; 小野文子; 大谷功; 明里宏文; 森一泰; 吉川泰弘; 倉田毅

  エイズ動物モデルの作成に関する研究 平成6年度研究報告書, 1995

  
• Anti-AIDS virus effects of 6-halo-ddP in the immune and central nervous systems.( Sponsor : Human Science Promotion Foundation ).

  村上邦睦; 町田誠; 藤井裕二; 向井りょう三郎; 明里宏文; 森一泰; 吉川泰弘; 落久保文子

  エイズ医薬品等開発研究報告 平成6年度, 1995

  

Books and Other Publications

• 感染症動物モデル−霊長類モデルを中心にー

  明里宏文

  実験医学増刊：パンデミック時代の感染症研究, Jan. 2021

  
• 実験用霊長類を用いた新規HIV感染モデルの樹立

  Anastasiia Kovba; 鷲崎 彩夏; 明里 宏文

  オベリスク, Jan. 2021

  
• Mammarian hepaciviruses

  東濃篤徳; 明里宏文, Joint work

  Atlas and textbook of pathogenic bacteria and viruses, Nov. 2017

  Find Kyoto University's collection of books :

  
• C型肝炎ウイルスワクチンとアジュバント

  加藤孝宣; 明里宏文

  次世代アジュバント開発のためのメカニズム解明と安全性評価, 2017, Not refereed

  
• サルT細胞白血病ウイルス（simian T-cell leukemia virus: STLV）

  明里宏文; 村田めぐみ

  実験動物ニュース, 65, 30-32, 2016, Not refereed

  
• 実験用霊長類の健康管理 — 感染症とその安全対策

  岡本宗裕; 明里宏文

  新・霊長類学のすすめ．187-198, 2012, Not refereed

  
• SRV-4の関与が疑われるニホンザルの血小板減少症

  鈴木樹理; 明里宏文; 岡本宗裕; 吉田友教; 岡林佐知

  オベリスク 17, 1, 2012, Not refereed

  
• 新しいC型肝炎の霊長類モデル

  明里 宏文

  生命のつづれ織り 3, 155-160, 2010, Not refereed

  
• エイズはサル起源なのですか？

  明里宏文, Contributor

  「新しい霊長類学｢人を深く知るための100問100答｣」 (京都大学霊長類研究所編) p.255-257 講談社, 2009, Not refereed

  
• 霊長類飼育実験施設におけるバイオセーフティ

  明里 宏文

  NBR Newsletter 3, 2-5, 2009, Not refereed

  

Industrial Property Rights

• 特願2022-2717, 特許権

  加藤孝宣; 明里宏文; 郷保正

  
• 特許第5315494号, 特開2009-189327, 特願2008-035178, ウイルス検査方法、及び、モデル動物

  明里 宏文; 高崎 智彦; 倉根 一郎

  
• 特開2009-189327, 特願2008-035178, ウイルス検査方法及びモデル動物

  明里 宏文

  

Awards

• 1997

  日本獣医学会, 獣医学奨励賞
• 2001

  National Institutes of Health, USA, The Fellows Award for Research Excellence

External funds: Kakenhi

• Synthetic studies of macrocyclic terpenoids toward development of highly selective anti-HIV seeds by controlling stereoconformation

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  Chihiro Tsukano

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  合成化学;有機化学;構造活性相関;全合成;生理活性;HIV

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19076/
• Trial of CD4 positive T cell induction from iPS cells

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Tatsuo Shioda

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  iPS;CD4;TRIM5;CCR5;サル;iPS細胞;アカゲザル;移植・再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05194/
• Elucidation of the onset and persistent mechanism of retrovirus induced thrombocytopenia in macaques and evaluation of their risks.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  MUNEHIRO OKAMOTO

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  ニホンザル;血小板減少症;SRV-4;SRV-5;感染実験;発症機序;カニクイザル;診断法;サリレトロウイルス;サルレトロウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04283/
• Trial of generating HIV-1-susceptible rhesus monkeys by using technologies in reproductive medicine

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University

  Tatsuo Shioda

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  HIV感染症;iPS細胞;再生医療;アカゲザル;iPS;CD4;HIV-1;再生医療技術;T細胞;サル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670218/
• Onset and persistent mechanism of retrovirus induced thrombocytopenia in Japanese macaques.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Munehiro OKAMOTO

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  ニホンザル;血小板減少症;SRV-4;発症機序;感染実験;SRV-5;感染持続

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24300153/
• Study of the roles of innate immunity on acute and chronic hepatitis C by a novel non-human primate model

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hirofumi AKARI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  個体;C型肝炎;動物モデル;自然免疫;HCV;GBV-B;NK細胞;CD16;新世界ザル;CD16(3G8);マーモセット;霊長類モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590526/
• MRI of the brain in a primate model of severe human malaria

  Grant-in-Aid for Scientific Research (C)

  Dokkyo Medical University

  Satoru KAWAI

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  磁気共鳴画像;MRI;脳マラリア;Plasmodium coatneyi;重症マラリア疾患モデル;マラリア疾患モデル, MRI;cerebral malaria;Plasmodium coatneyi;primate model;severe human malaria

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590404/
• Gene therapy of Hepatitis C using monkey by siRNA

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Takanori YOKOTA

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  RNA干渉;siRNA;AAV;タマリン;shRNA;マンモセット;GBV-B;ビタミンE;新世界ザル;カチオニックベクター;C型肝炎;AAV8;インターフェロン, RNA interference;siRNA;AAV;Tamarin;shRNA;marmoset;GBV-B;Vitamin E

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390215/
• Gene therapy of Hepatitis C using monkey by siRNA

  Grant-in-Aid for Scientific Research (B)

  Department of Neurology and Neurological Science, Tokyo medicak and Dental University

  Takanori YOKOTA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  RNA干渉;siRNA;カチオニックベクター;C型肝炎;タマリン;マーモセット;GBV-B;インテーフェロン;インターフェロン;HCV, RNA interference;siRNA;cationic vector;Hepatitis C;tamarin;marmoset;GBV-B;interferon

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390204/
• HIV−1vif遺伝子機能に関する分子遺伝学的解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokushima

  明里 宏文

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11770160/
• Basic studies on strategy against HIV

  Grant-in-Aid for Scientific Research (B).

  The University of Tokushima

  Akio ADACHI

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  HIV;Gag;Env;Vif;Vpr;Nef;アポトーシス;MHC-I;キャプシド, HIV;Gag;Env;Vif;Vpr;Nef;Apoptosis;MHC-I

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11557024/
• Cell biology of HIV-1 Nef and Vpr

  Grant-in-Aid for Scientific Research (B)

  The University of Tokushima

  Akio ADACHI

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  HIV;Nef;Vpr;MHC-I;CD4;アポトーシス, HIV;Nef;Vpr;MHC-I;CD4;Apoptosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470078/

External funds: others

• 経胎盤感染予防に資する次世代HTLV-1抗体医薬製剤開発研究

  AMED・新興･再興感染症に対する革新的医薬品等開発推進研究事業

  From 2023, To 2025

  分担
• HBV cccDNAの産生と維持に関わるウイルス及び宿主因子の探索

  AMED・肝炎等克服実用化研究事業

  From 2022, To 2024

  分担
• 成人T細胞白血病細胞の抗原性増大による新規免疫療法の開発

  AMED・次世代がん医療創生研究事業

  From 2021, To 2022

  分担
• 抗HTLV-1ヒト免疫グロブリンによる母子感染予防法の開発及びHTLV-1抗体医薬品製剤化に関する総合的研究

  AMED・新興･再興感染症に対する革新的医薬品等開発推進研究事業

  From 2021, To 2023

  分担
• SARS-Cov-2に対する抗体ミメティックを活用した治療薬開発

  AMED・新興再興感染症に対する革新的医薬品等開発推進研究事業

  From 2020, To 2020

  分担
• HIV感染霊長類モデルを用いたHIV根治療法の有効性評価に関する研究

  AMED・エイズ対策実用化研究事業

  From 2020, To 2022

  代表
• HTLV-1の総合的な感染対策に資する研究

  AMED・新興再興感染症に対する革新的医薬品等開発推進研究事業

  From 2020, To 2022

  分担
• 成人T細胞白血病細胞の免疫原性に基づく新規細胞治療法の開発

  AMED・次世代がん医療創生研究事業

  From 2019, To 2020

  分担
• 臨床応用を目指した抗HTLV-1ヒト免疫グロブリンによるHTLV-1感染予防法の開発と安全性に関する研究

  AMED・新興再興感染症に対する革新的医薬品等開発推進研究事業

  From 2018, To 2020

  分担
• 効果的な新規B型肝炎ウイルスワクチンの開発を目指した基礎的研究

  AMED・肝炎等克服実用化研究事業

  From 2017, To 2019

  分担
• HIV感染症の根治療法創出のための基礎・応用研究

  AMED・ｴｲｽﾞ対策実用化研究事業

  From 2017, To 2019

  代表
• 抗HTLV-1ヒト免疫グロブリン等による HTLV-1 感染予防法の開発に関する研究

  AMED・新興再興感染症に対する革新的医薬品等開発推進研究事業

  From 2015, To 2017

  分担
• HIV感染症の根治に向けた基盤的研究

  AMED・エイズ対策実用化研究事業

  From 2014, To 2016

  代表

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  9653, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Primate Cellular and Molecular Biology

  9643, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Practice on Laboratory Animal Science

  9636, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Interdisciplinary Seminar on Primatology

  9572, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Conservation Biology and Primate Medicine B

  9691, Fall, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Conservation Biology and Primate Medicine A

  9690, Spring, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Conservation Biology and Primate Medicine D

  9693, Fall, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Conservation Biology and Primate Medicine C

  9692, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Practice on Laboratory Animal Science

  9636, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Interdisciplinary Seminar on Primatology

  9572, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  9653, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Primate Cellular and Molecular Biology

  9643, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Conservation Biology and Primate Medicine B

  9691, Fall, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Conservation Biology and Primate Medicine A

  9690, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Conservation Biology and Primate Medicine D

  9693, Fall, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Conservation Biology and Primate Medicine C

  9692, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Primatology II

  N910, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  9637, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Conservation Biology and Primate Medicine C

  9692, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  9653, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Conservation Biology and Primate Medicine A

  9690, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Practice on Laboratory Animal Science

  9636, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Conservation Biology and Primate Medicine D

  9693, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Conservation Biology and Primate Medicine B

  9691, Fall, Graduate School of Science, 2
• From Apr. 2011, To Mar. 2012

  霊長類実験動物科学ゼミナールⅠA

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  霊長類実験動物科学ゼミナールⅠB

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  霊長類実験動物科学ゼミナールⅡA

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  霊長類実験動物科学ゼミナールⅡB

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  実験動物科学基礎論

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  実験動物科学特論

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  Primatology Today

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Topics in Primatology

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Introduction of primate virology

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Fundamental Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Laboratory Animal Science

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Laboratory Animal Science IA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Laboratory Animal Science IB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Laboratory Animal Science IIA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Laboratory Animal Science IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Fundamental Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Laboratory Animal Science

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Introduction of primate virology

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminar on Laboratory Animal Science IA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Laboratory Animal Science IB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Laboratory Animal Science IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Laboratory Animal Science IIB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Monkey Handling Training

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Practice on Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Practice on Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Primatology II

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Practice on Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Primatology II

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Practice on Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Primatology II

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Advanced Lectures in Primate Conservation Biology and Primate Medicine

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Practice on Laboratory Animal Science

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Conservation Biology and Primate Medicine A

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Conservation Biology and Primate Medicine B

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Conservation Biology and Primate Medicine C

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Conservation Biology and Primate Medicine D

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Fundamental Lectures in Primate Conservation Biology and Primate Medicine

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Primatology II

  Fall, 全学共通科目

Participation in PhD Defense

• Facial Expressions and Behaviours Associated with Pain in Japanese Macaques

  VANESSA NADINE GRIS, Graduate School of Science, Chief Examiner

  23 May 2023
• Development of novel mosaic adeno-associated virus vector for stable manipulation and imaging of neural activity in nonhuman primate brains

  KIMURA KEI, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024
• Feeding ecology of golden-faced sakis in a forest fragment in Manaus, Brazil: Comparison to sympatric squirrel monkeys

  TAKE MAKIKO, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024
• Linking Sociability to Parasite Infection in Macaques

  XU ZHIHONG, Graduate School of Science, Sub-chief Examiner

  25 Sep. 2023
• マカクサル由来腸管オルガノイド培養系の樹立と機能的なマカク腸管tuft細胞の作出

  INABA AKIHIKO, Graduate School of Science, Sub-chief Examiner

  24 Jul. 2023
• Innovation of Non-Invasive Endocrine Assays for Primates in the Wild

  MOURI KEIKO, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024

Administration

School management (title, position)

• From 15 Jul. 2022, To 30 Sep. 2024

  動物実験委員会
• From 01 Apr. 2023, To 31 Mar. 2025

  学生生活委員会第三小委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2025

  学生生活委員会 委員

Faculty management (title, position)

• From 01 Apr. 2021, To 31 Mar. 2023

  理学研究科大学院教育教務委員会委員

Academic, Social Contribution

Committee Memberships

• From Oct. 2021, To Present

  代議員, 日本エイズ学会
• From 2019, To Present

  評議員, 日本獣医学会
• From 2018, To Present

  評議員, 日本ウイルス学会
• From 2017, To Present

  運営委員, ナショナルバイオリソースプロジェクト「ニホンザル」
• From 2014, To 2015

  評議員, 日本実験動物学会