Basic Information

Faculty

• 理学部

Professional Memberships

• 日本免疫学会
• 日本生化学会

Academic Degree

• 工学修士(広島大学)
• 博士（工学）(広島大学)

Academic Resume (Graduate Schools)

• 広島大学, 大学院工学研究科博士課程（前期）工業化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 広島大学, 工学部第三類（化学系）, 卒業

Research History

• From 2015, To Present

  同准教授
• From 1999, To 2002

  Kyoto University, Graduate School of Biostudies
• From 1999, To 2002

  Graduate School of Bio studies, Kyoto University. Instructor
• From 2002

  - 京都大学大学院生命科学研究科講師
• From 2002

  - Graduate School of Biostudies, Kyoto University, Lecturer
• From 1997, To 1999

  Kyoto University, Faculty of Science
• From 1997, To 1999

  Graduate School of Science, Kyoto University. Instructor, 大学院理学研究科
• From 1993, To 1997

  米国ウィスコンシン大学医学部病理学ポストドクトラルフェロー
• From 1993, To 1997

  Post doctoral fellow, Dep. of Pathology. University of Wisconsin
• From 1986, To 1993

  宝酒造(株)研究員
• From 1986, To 1993

  Researcher, Takara shuzo
• From 1988, To 1990

  国立ガンセンター研究所派遣研究員
• From 1988, To 1990

  National Cancer Center Research Institute.
• From 1987, To 1988

  大阪大学細胞工学センター派遣研究員
• From 1987, To 1988

  Institute for Molecular and cellular Biology, Osaka University

Profile

• Profile

  これまでの研究内容
  
  1. ヒトV型コラーゲン遺伝子のクローニングとEhlers-Danlos症候群における変異の同定
  
  V型コラーゲンは他の繊維状コラーゲンの径･強度を制御すると考えられていた。そこで、当該cDNAをクローニングし、さらに遺伝子（Exon-Intron）構造を明らかにした。その結果、V型コラーゲンにはN末端非コラーゲン領域が存在し、これが繊維の径・強度に影響を与えるものと考えられた。さらに、皮膚、関節、血管等の脆弱性を示すEhlers-Danlos症候群の患者で、V型コラーゲン遺伝子の転座およびN末端非コラーゲン領域にてExon skipが生じる変異を同定した。
  
  
  2. コラーゲンの不溶化に働く酵素の同定
  
  コラーゲン前駆体は可溶性で、細胞外でC末端非コラーゲン領域が切断され不溶化する。しかし、その切断部位は非特異的分解を受けやすく、切断酵素の同定が困難であった。そこで始めに、当該切断活性を促進する因子PCOLCEをクローニングした。PCOLCEは蛋白間結合に働くCUBドメイン有していた。そこで、同ドメインを有するハエ胚背腹軸形成因子BMP-1を上記切断酵素であると予想し、これを証明した。以上の研究より、長年課題であったコラーゲンの不溶化機構を明らかにした。
  
  
  3. 免疫系細胞に発現するレクチンの同定と糖鎖認識に関する研究
  
  樹状細胞 (dendritic cell, DC)やマクロファージ（macrophage, Mf）は、多様なpattern recognition receptor（PRR）により病原体を認識する。このPRRの一つであるレクチンの機能を解析するために、マウスDC/Mfに発現するランゲリンおよび5個のSIGNRファミリー遺伝子を新規に同定し機能を解析した。続いて、その中のSIGNR1がサルモネラやキャンディダ等を認識し、サイトカイン産生を昂進する事を示した。また、それら病原体表面のSIGNR1認識糖鎖構造を明らかにした。
  
  
  4. 病原体認識における異なるPRRの共同作用に関する研究
  
  実際の免疫細胞による病原体認識は、多様なPRRにより同時に起こる。そこで、SIGNR1を中心に他のPRRとの共同作用を検討した。その結果、SIGNR1が同じくレクチンであるDectin-1や、タイプの異なるtoll-like receptor (TLR)2および4と物理的に会合し、殺菌性酸素種および炎症性サイトカインの産生を昂進する事を見出した。
  
  
  5. レクチンを介した免疫抑制機構に関する研究
  
  C. albicans表面の可溶性糖蛋白はヒトを免疫抑制状態に導く。そこでヒトレクチンDC-SIGNの同機構への関与を検討した。先ず、糖鎖アレイ解析でDC-SIGNは病原性C. albicans N-glycanには結合するが、非病原性のS. cerevisiae のそれには結合しないことを示した。また、DC-SIGN発現RAW264.7細胞株は、S. cerevisiaeよりもC. albicansのN-glycanに対して多くの免疫抑制性サイトカインIL-10を産生した。よって、C. albicansは当該N-glycanおよび宿主DC-SIGNを介して免疫応答を抑制すると思われる。
  
  
  6. 微細粒子に対するサイズ依存的な細胞応答経路の解析
  
  シリカやアスベスト等の微細粒子はDC/MfからのIL-1bの産生を誘導する。しかし、これ迄は被検粒子が様々サイズの混合物であった為、粒子のサイズに依存する細胞応答が存在するかは不明であった。そこで、骨髄由来Mfを様々な大きさのラッテクスビーズ（LxB）で刺激したところ、1,000および20 nm径LxBはIL-1bの産生を誘導するが、100 nm径LxBはしないことを見出した。さらに1,000 nm径LxBはミトコンドリアからの活性酸素種依存的、20 nm径LxBは食胞からのcathepsin Bの漏出依存的に、独立してIL-1b産生に働くことが示された。これらの結果は、粒子サイズ依存的な応答経路の存在を示し、また、微細粒子の生体毒性機構の解明と新たな治療法の開発に寄与するものと考える。

Language of Instruction

• English

ID,URL

• J-Global ID

  200901088899721341

• External link

  http://zoo.zool.kyoto-u.ac.jp/imm/

researchmap URL

• https://researchmap.jp/read0057493

Research

Research Topics, Overview of the research

• Research Topics

  Development of new methods to control immune reactions though understanding immune system.

• Overview of the research

  Our interest is the induction and control of immunity. We focus on dendritic cells (DC), which are a primary antigen-presenting cell in the immune system. We are especially interested in functions of lectin molecules expressed on DC and its relative, macrophage, that recognize polysaccharides on pathogenic agents. The study includes analyses of interaction between polysaccharides and lectins, and subsequent cellular and systemic responses in co-operation with TLR signaling. In this study, we found that certain lectin-polysaccharide interaction induced immune suppressive environment, ameliorating excessive and lethal inflammation. By these studies, we would like to develop new methods to control immune system.

Research Interests

• 樹状細胞
• レクチン
• 免疫学
• Dendritic Cells
• Lectin
• Immunology

Research Areas

• Life sciences, Immunology
• Life sciences, Experimental pathology

Papers

• Vγ5Vδ1 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs

  Koichi Sudo; Takero Todoroki; Yuyo Ka; Kazuhiko Takahara

  International Immunology, Jan. 2022, Peer-reviewed, Corresponding author

  
• Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

  Kawakita, M., Oyama, T., Shirai, I., Tanaka, S., Akaki, K., Abe, S., Asahi, T., Cui, G., Itoh, F., Sasaki, M., Shibata, N., Ikuta, K., Hatakeyama, T. and Takahara, K.

  Commun. Biol., Mar. 2021, Peer-reviewed, Corresponding author

  
• IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.

  Guangwei Cui; Akihiro Shimba; Guangyong Ma; Kazuhiko Takahara; Shizue Tani-Ichi; Yuanbo Zhu; Takuma Asahi; Akifumi Abe; Hitoshi Miyachi; Satsuki Kitano; Takahiro Hara; Jun-Ichirou Yasunaga; Hirotsugu Suwanai; Hisakata Yamada; Masao Matsuoka; Kohjiro Ueki; Yasunobu Yoshikai; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 15 Feb. 2020, Peer-reviewed

  
• Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

  Takeo Goji; Kazuhiko Takahara; Manabu Negishi; Hironori Katoh

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2017, Peer-reviewed

  
• Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice

  Toshifumi Ishiguro; Tetsuya Fukawa; Kotaro Akaki; Koji Nagaoka; Tatsuki Takeda; Yoichiro Iwakura; Kayo Inaba; Kazuhiko Takahara

  EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2017, Peer-reviewed

  
• In vivo and in vitro analyses of alpha-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative

  Maki Ushida; Tomonori Iyoda; Mitsuhiro Kanamori; Hiroshi Watarai; Kazuhiko Takahara; Kayo Inaba

  IMMUNOLOGY LETTERS, Dec. 2015, Peer-reviewed, Corresponding author

  
• Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis

  Sumika Tokieda; Marie Komori; Toshifumi Ishiguro; Yoichiro Iwakura; Kazuhiko Takahara; Kayo Inaba

  BMC IMMUNOLOGY, Oct. 2015, Peer-reviewed, Corresponding author

  
• Amyloid beta oligomers induce interleukin-1 beta production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner

  Jun Taneo; Takumi Adachi; Aiko Yoshida; Kunio Takayasu; Kazuhiko Takahara; Kayo Inaba

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2015, Peer-reviewed

  
• Particle Size of Latex Beads Dictates IL-1 beta Production Mechanism

  Takumi Adachi; Kazuhiko Takahara; Jun Taneo; Yasuo Uchiyama; Kayo Inaba

  PLOS ONE, Jul. 2013, Peer-reviewed

  
• IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms

  Kento Minamino; Kazuhiko Takahara; Takumi Adachi; Koji Nagaoka; Tomonori Iyoda; Shinsuke Taki; Kayo Inaba

  INTERNATIONAL IMMUNOLOGY, Sep. 2012, Peer-reviewed

  
• Difference in Fine Specificity to Polysaccharides of Candida albicans Mannoprotein between Mouse SIGNR1 and Human DC-SIGN

  Kazuhiko Takahara; Takuya Arita; Sumika Tokieda; Nobuyuki Shibata; Yoshio Okawa; Hiroaki Tateno; Jun Hirabayashi; Kayo Inaba

  INFECTION AND IMMUNITY, May 2012, Peer-reviewed

  
• Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-alpha production

  Kazuhiko Takahara; Sumika Tokieda; Koji Nagaoka; Kayo Inaba

  INTERNATIONAL IMMUNOLOGY, Feb. 2012, Peer-reviewed

  
• GM-CSF-Independent CD1a Expression in Epidermal Langerhans Cells: Evidence from Human CD1A Genome-Transgenic Mice

  Chisa Kobayashi; Takashi Shiina; Atsuko Tokioka; Yuki Hattori; Takaya Komori; Mikiko Kobayashi-Miura; Toshihiro Takizawa; Kazuhiko Takahara; Kayo Inaba; Hidetoshi Inoko; Motohiro Takeya; Glenn Dranoff; Masahiko Sugita

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jan. 2012, Peer-reviewed

  
• C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1

  Kazuhiko Takahara; Sumika Tokieda; Koji Nagaoka; Tatsuki Takeda; Yukino Kimura; Kayo Inaba

  EUROPEAN JOURNAL OF IMMUNOLOGY, May 2011, Peer-reviewed

  
• Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes

  Koji Nagaoka; Kazuhiko Takahara; Kento Minamino; Tatsuki Takeda; Yoko Yoshida; Kayo Inaba

  JOURNAL OF LEUKOCYTE BIOLOGY, Nov. 2010, Peer-reviewed

  
• Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1

  Dong-Min Shin; Chul-Su Yang; Jae-Min Yuk; Ji-Yeon Lee; Ki Hye Kim; Sung Jae Shin; Kazuhiko Takahara; Sung Joong Lee; Eun-Kyeong Jo

  CELLULAR MICROBIOLOGY, Aug. 2008, Peer-reviewed

  
• Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria

  K Nagaoka; K Takahara; H Yoshida; RM Steinman; S Saitoh; S Akashi-Takamura; K Miyake; YS Kang; CG Park; K Inaba

  INTERNATIONAL IMMUNOLOGY, Jul. 2005, Peer-reviewed

  
• Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins

  K Takahara; Y Yashima; Y Omatsu; H Yoshida; Y Kimura; YS Kang; RM Steinman; CG Park; K Inaba

  INTERNATIONAL IMMUNOLOGY, Jun. 2004, Peer-reviewed

  
• Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2

  E Ichikawa; S Hida; Y Omatsu; S Shimoyama; K Takahara; S Miyagawa; K Inaba; S Taki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2004, Peer-reviewed

  
• Transforming growth factor-beta induces secretion of activated ADAMTS-2 - A procollagen IIIN-proteinase

  WM Wang; S Lee; BM Steiglitz; IC Scott; CC Lebares; ML Allen; MC Brenner; K Takahara; DS Greenspan

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed

  
• SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran

  YS Kang; S Yamazaki; T Iyoda; M Pack; SA Bruening; JY Kim; K Takahara; K Inaba; RM Steinman; CG Park

  INTERNATIONAL IMMUNOLOGY, Feb. 2003, Peer-reviewed

  
• PCOLCE deletion and expression analyses in uterine leiomyomata

  AH Ligon; IC Scott; K Takahara; DS Greenspan; CC Morton

  CANCER GENETICS AND CYTOGENETICS, Sep. 2002, Peer-reviewed

  
• Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha 1(V) N-propeptides and Ehlers-Danlos syndrome type I

  K Takahara; U Schwarze; Y Imamura; GG Hoffman; H Toriello; LT Smith; PH Byers; DS Greenspan

  AMERICAN JOURNAL OF HUMAN GENETICS, Sep. 2002, Peer-reviewed

  
• The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo

  T Iyoda; S Shimoyama; K Liu; Y Omatsu; Y Akiyama; Y Maeda; K Takahara; RM Steinman; K Inaba

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2002, Peer-reviewed

  
• Identification and expression of mouse Langerin (CD207) in dendritic cells

  K Takahara; Y Omatsu; Y Yashima; Y Maeda; S Tanaka; T Iyoda; BE Clausen; K Matsubara; J Letterio; RM Steinman; Y Matsuda; K Inaba

  INTERNATIONAL IMMUNOLOGY, May 2002, Peer-reviewed

  
• Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells

  N Ichioka; M Inaba; T Kushida; T Esumi; K Takahara; K Inaba; R Ogawa; H Iida; S Ikehara

  STEM CELLS, 2002, Peer-reviewed

  
• Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN

  CG Park; K Takahara; E Umemoto; Y Yashima; K Matsubara; Y Matsuda; BE Clausen; K Inaba; RM Steinman

  INTERNATIONAL IMMUNOLOGY, Oct. 2001, Peer-reviewed

  
• Lack of BMP-1 gene mutations in patient with gastroschisis

  Komuro, H

  J. Pediatric Surgery 36, 885-887, 2001, Peer-reviewed

  
• マウス樹状細胞におけるCD8αの誘導と活性化

  山出 史也; 梅本 英司; 中島 康祐; 三鴨 晋也; 高原 和彦; 稲葉 カヨ

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain

  S Amano; IC Scott; K Takahara; M Koch; MF Champliaud; DR Gerecke; DR Keene; DL Hudson; T Nishiyama; S Lee; DS Greenspan; RE Burgeson

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2000, Peer-reviewed

  
• Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor

  JD Mott; CL Thomas; MT Rosenbach; K Takahara; DS Greenspan; MJ Banda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2000, Peer-reviewed

  
• Mammalian BMP-1/tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis

  IC Scott; IL Blitz; WN Pappano; Y Imamura; TG Clark; BM Steiglitz; CL Thomas; SA Maas; K Takahara; KWY Cho; DS Greenspan

  DEVELOPMENTAL BIOLOGY, Sep. 1999, Peer-reviewed

  
• Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein

  IC Scott; TG Clark; K Takahara; GG Hoffman; DS Greenspan

  GENOMICS, Jan. 1999, Peer-reviewed

  
• Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32 -> q33 and 10q23 -> q24 and assignment of murine Tll2 to chromosome 19

  IC Scott; TG Clark; K Takahara; GG Hoffman; RL Eddy; LL Haley; TB Shows; DS Greenspan

  CYTOGENETICS AND CELL GENETICS, 1999, Peer-reviewed

  
• Transforming growth factor-beta regulation of bone morphogenetic protein-1 procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes

  SB Lee; DE SolowCordero; E Kessler; K Takahara; DS Greenspan

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1997, Peer-reviewed

  
• Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid

  N Suzuki; PA Labosky; Y Furuta; L Hargett; R Dunn; AB Fogo; K Takahara; DMP Peters; DS Greenspan; BLM Hogan

  DEVELOPMENT, Nov. 1996, Peer-reviewed

  
• A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito

  HV Toriello; TW Glover; K Takahara; PH Byers; DE Miller; JV Higgins; DS Greenspan

  NATURE GENETICS, Jul. 1996, Peer-reviewed

  
• Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid bone morphogenetic protein-1

  K Takahara; R Brevard; GG Hoffman; N Suzuki; DS Greenspan

  GENOMICS, Jun. 1996, Peer-reviewed

  
• Bone morphogenetic protein-1: The type I procollagen C-proteinase

  E Kessler; K Takahara; L Biniaminov; M Brusel; DS Greenspan

  SCIENCE, Jan. 1996, Peer-reviewed

  
• Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein

  K Takahara; L Osborne; RW Elliott; LC Tsui; SW Scherer; DS Greenspan

  GENOMICS, Jan. 1996, Peer-reviewed

  
• Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L

  K Takahara; M Bong; R Brevard; RL Eddy; LL Haley; SJ Sait; TB Shows; GG Hoffman; DS Greenspan

  GENOMICS, Jan. 1996, Peer-reviewed

  
• COMPLETE STRUCTURAL ORGANIZATION OF THE HUMAN ALPHA-1(V) COLLAGEN GENE (COL5A1) - DIVERGENCE FROM THE CONSERVED ORGANIZATION OF OTHER CHARACTERIZED FIBRILLAR COLLAGEN GENES

  K TAKAHARA; GG HOFFMAN; DS GREENSPAN

  GENOMICS, Oct. 1995, Peer-reviewed

  
• STRUCTURAL ORGANIZATION AND GENETIC LOCALIZATION OF THE HUMAN BONE MORPHOGENETIC PROTEIN-1 MAMMALIAN TOLLOID GENE

  K TAKAHARA; S LEE; S WOOD; DS GREENSPAN

  GENOMICS, Sep. 1995, Peer-reviewed

  
• BONE MORPHOGENETIC PROTEIN-1 AND A MAMMALIAN TOLLOID HOMOLOG (MTLD) ARE ENCODED BY ALTERNATIVELY SPLICED TRANSCRIPTS WHICH ARE DIFFERENTIALLY EXPRESSED IN SOME TISSUES

  K TAKAHARA; GE LYONS; DS GREENSPAN

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1994, Peer-reviewed

  
• TYPE-I PROCOLLAGEN COOH-TERMINAL PROTEINASE ENHANCER PROTEIN - IDENTIFICATION, PRIMARY STRUCTURE, AND CHROMOSOMAL LOCALIZATION OF THE COGNATE HUMAN GENE (PCOLCE)

  K TAKAHARA; E KESSLER; L BINIAMINOV; M BRUSEL; RL EDDY; S JANISAIT; TB SHOWS; DS GREENSPAN

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1994, Peer-reviewed

  
• ALTERNATIVE SPLICING OF BOVINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE CDNA

  K TAKAHARA; N HAYASHI; K FUJITASAGAWA; T MORISHITA; Y HASHIMOTO; A NODA

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Apr. 1994, Peer-reviewed

  
• EFFECTS OF FIBRONECTIN-TYPE-V COLLAGEN RECOMBINANT FUSION PROTEIN ON CELL-ADHESION AND CELL-PROLIFERATION

  M HATAI; K TAKAHARA; H HASHI; KATO, I; Y YAOI

  CELL STRUCTURE AND FUNCTION, Oct. 1992, Peer-reviewed

  
• COMPLETE PRIMARY STRUCTURE OF HUMAN COLLAGEN ALPHA-1(V) CHAIN

  K TAKAHARA; Y SATO; K OKAZAWA; N OKAMOTO; A NODA; Y YAOI; KATO, I

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed

  
• INSULIN BINDS TO TYPE-V COLLAGEN WITH RETENTION OF MITOGENIC ACTIVITY

  Y YAOI; K HASHIMOTO; K TAKAHARA; KATO, I

  EXPERIMENTAL CELL RESEARCH, Jun. 1991, Peer-reviewed

  
• ENDOGENOUS RETROVIRAL LTR DNA-SEQUENCES AS MARKERS FOR INDIVIDUAL HUMAN-CHROMOSOMES

  N NAKAMURA; H SUGINO; K TAKAHARA; C JIN; S FUKUSHIGE; K MATSUBARA

  CYTOGENETICS AND CELL GENETICS, 1991, Peer-reviewed

  
• PRIMARY STRUCTURE OF THE HEPARIN-BINDING SITE OF TYPE-V COLLAGEN

  Y YAOI; K HASHIMOTO; H KOITABASHI; K TAKAHARA; M ITO; KATO, I

  BIOCHIMICA ET BIOPHYSICA ACTA, Aug. 1990, Peer-reviewed

  
• A YEAST SYSTEM FOR STABLE EXPRESSION OF HEPATITIS-B SURFACE-ANTIGEN

  K SHIOSAKI; Y MIYATSU; K TAKAHARA; H MIZOKAMI; F HAMADA; K MATSUBARA

  JOURNAL OF BIOTECHNOLOGY, Jun. 1990, Peer-reviewed

  
• ASSIGNMENT OF HUMAN PEPSINOGEN-C (PGC) GENE TO CHROMOSOME-6

  K TAKAHARA; S FUKUSHIGE; T MUROTSU; Y ICHIHARA; T HAYANO; T ISHIHARA; K TAKAHASHI; K MATSUBARA

  CYTOGENETICS AND CELL GENETICS, 1989, Peer-reviewed

  

Misc.

• 樹状細胞による免疫寛容の誘導と維持 (特集1 制御性T細胞:免疫応答を負に制御する)

  高原 和彦; 稲葉 カヨ

  細胞工学, Nov. 2002

  
• 樹状細胞上のC-タイプレクチン群とそのリガンド

  高原 和彦; 長岡 孝治; 吉田 英雄

  臨床免疫, Feb. 2005

  
• 樹状細胞の抗原プロセシングと腫瘍免疫 (9月第5土曜特集 造血の再生医学と細胞療法) -- (腫瘍免疫の制御)

  高原 和彦; 稲葉 カヨ

  医学のあゆみ, 30 Sep. 2000

  
• Inflammation induced by small particles

  足立 匠; 高原 和彦; 稲葉 カヨ

  臨床免疫・アレルギー科, Dec. 2013

  
• Enhancement of TLR4 response by SIGNR1

  TAKAHARA Kazuhiko; NAGAOKA Koji; SAITOH Shin-ichroh; TAKEDA Tatsuki; AKASHI-TAKAMURA Sachiko; MIYAKE Kensuke; INABA Kayo

  日本免疫学会総会・学術集会記録, 2005

  
• マウスDC-SIGNホモログSIGNR1によるグラム陰性菌の認識とTLR4応答におよぼす影響

  高原 和彦; 長岡 孝治; 吉田 英雄; 斉藤 伸一郎; 高村 祥子; 司; 三宅 健介; 稲葉 カヨ

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• 樹状細胞におけるRP105とTLR-4の発現

  山出 史也; 壬生 優子; 赤司 祥子; 高原 和彦; 三宅 健介; 木本 雅夫; 稲葉 カヨ

  日本免疫学会総会・学術集会記録, Oct. 1999

  
• Novel matrix metalloproteinase inhibitor in human brain tumors

  JD Mott; K Takahara; MT Rosenbach; CL Thomas; S Lee; DS Greenspan; MJ Banda

  FASEB JOURNAL, Jul. 1997

  
• The gamma-2 chain of laminin 5 is processed by BMP-1 and processing is essential to basement membrane assembly in vivo.

  S Amano; K Takahara; DR Gerecke; T Nishiyama; S Lee; DS Greenspan; B Hogan; DE Birk; RE Burgeson

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1997

  
• Bone morphogenetic protein-1 is the processing enzyme for laminin 5 in human keratinocytes.

  S Amano; K Takahara; D Gerecke; T Nishiyama; S Lee; DS Greenspan; RE Burgeson

  MOLECULAR BIOLOGY OF THE CELL, Dec. 1996

  

Presentations

• 微細な粒子/蛋白凝集体はそのサイズ・形状により異なる細胞内応答経路を活性化する

  広島醗酵会総会・公開講演会, 02 Nov. 2013, 広島醗酵会

  
• 粒子サイズによる細胞応答性の差異

  高原 和彦

  京都環境ナノクラスター主催「ナノ材料の安全性・社会受容に関するシンポジウム」, 2012

  
• Role of SIGN-related molecules in innate immune responses

  TAKAHARA Kazuhiko

  CREST Symposium, 2009

  

Books and Other Publications

• 京大発 フロンティア生命科学

  高原 和彦, Contributor, 13.1節

  講談社, Mar. 2018, Not refereed

  
• Immune regulation though C-type lectin: Their roles in homeostasis and application

  高原 和彦

  Clinical Immunology & Allergology, Aug. 2016, Not refereed

  
• 微細粒子物質による炎症惹起

  足立 匠; 高原 和彦; 稲葉 カヨ

  臨床免疫・アレルギー科, Dec. 2013, Not refereed

  
• C-型レクチンDC-SIGNを介したIL-10産生と免疫制御.

  高原 和彦; 石黒 俊史

  臨床免疫・アレルギー科, Dec. 2013, Not refereed

  
• 樹状細胞に発現するCタイプレクチンDCIR（Dendritic cell immunoreceptor）の機能と生体における働き）

  高原 和彦

  臨床免疫アレルギー科, 2009, Not refereed

  
• 樹状細胞み発現するC型レクチンの機能とシグナル伝達

  高原 和彦

  実験医学, 2008, Not refereed

  
• マウスC型レクチンSIGNR1とその免疫応答における役割

  長岡 孝治

  臨床免疫, 2006, Not refereed

  
• 樹状細胞上のC-タイプレクチン群とそのリガンド

  高原 和彦

  科学評論社, 2005, Not refereed

  
• 樹状細胞におけるパターン認識レセプターとしてのレクチン

  高原 和彦

  臨床免疫, 2003, Not refereed

  
• 樹状細胞による免疫寛容の誘導と維持

  高原 和彦

  細胞工学, 2002, Not refereed

  
• 樹状細胞の抗原プロセッシングと腫瘍免疫

  高原 和彦

  医学の歩み, 2000, Not refereed

  
• 樹状細胞による抗原ペプチドの提示とその腫瘍免疫への応用

  高原 和彦

  現代医学, 2000, Not refereed

  
• 抗腫瘍免疫療法における樹状細胞

  高原 和彦

  最新医学, 1999, Not refereed

  
• 生体防御における樹状細胞の役割と応用

  高原 和彦

  バイオインダストリ-協会, 1998, Not refereed

  
• BMP-1とI型プロコラーゲンC-プロテイナーゼ

  高原 和彦

  実験医学, 1996, Not refereed

  
• Technical Study on Analysis of Double Stained Human Chromosomes

  高原 和彦

  "Flow cytometry and image analysis for clinical application" Elsevier Science Publishers B. V.,/,89-94, Apr. 1991, Not refereed

  
• 人染色体のソーティング

  高原 和彦

  細胞工学, 1988, Not refereed

  

Industrial Property Rights

• 特開特開平11-092396 インスリン結合阻害剤, インスリン結合阻害剤

  
• 特開特開平11-092404, インスリン結合用担体

  
• 特許US Issued Patent No. 5939321, Mammalian Tolloid-Like Gene and Protein

  
• 特開特開平07-039378, 逆転写酵素遺伝子

  
• 特開特開平06-105687, ヒトコラーゲンＶ型遺伝子

  
• 特開特開平05-097698, 機能性ポリペプチド

  
• 特開特開平02-209899, インスリン結合活性を有するポリペプチド

  

Awards

• 2004

  日本免疫学会発行誌, Outstanding Merit Award from International Immunology
• 2006

  日本免疫学会発行誌, Outstanding Merit Award from International Immunology

External funds: Kakenhi

• 病原体の免疫抑制機構を利用した致死的サイトカインストームを抑制する糖鎖の開発

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49030:Experimental pathology-related

  Kyoto University

  高原 和彦

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  敗血症;サイトカインストーム;Candida albicans;糖鎖;IL-10

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06969/
• 自然免疫系レセプターの胎生期リンパ球発生における新たな働き

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  高原 和彦

  From 30 Jul. 2020, To 31 Mar. 2023, Declined

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21524/
• Immune control by polysaccharides derived from microbes

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko Takahara

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  微生物糖鎖;敗血症;免疫抑制;免疫賦活;C. albicans;レクチン;IL-10;IFN-gamma;糖鎖;免疫制御;ワクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08737/
• IL-1beta production depending on size of insoluble material generated in vivo

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Kayo INABA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  微細粒子;IL-1β;アミロイド β;炎症;凝集体;マイクログリア;アミロイド-b;原子間力顕微鏡;IL-1beta;アミロイド-beta;尿酸結晶

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670192/
• Immune regulation though C-type lectin using microbial polysaccharides

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko Takahara

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  C. albicans;C型レクチン;糖鎖;IL-10;免疫制御;免疫抑制;レクチン;敗血症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460494/
• Biological studies of size-effect by nano-particles

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Kayo INABA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  炎症;ナノ粒子;サイズ効果;マクロファージ;サイトカイン;ラテックスビーズ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659203/
• Observation of in vivo dynamics of macrophage subsets based on expression of lectin molecule

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko TAKAHARA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  細胞;レクチン;マクロファージ;樹状細胞;単球

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590417/
• 糖鎖認識におけるSIGNR1と他のファミリー分子における差異の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  高原 和彦

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  微生物;感染症;糖鎖;免疫学;レクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21022021/
• ナノ物質に対する細胞応答性とその差異の検討

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  稲葉 カヨ

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  マクロファージ;肺;ナノ;内皮細胞;線維芽細胞;繊維芽細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20659036/
• Functional analyses of mouse lectin SIGNR family

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko TAKAHARA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  レクチン;単クローン抗体;微生物;マクロファージ;樹状細胞;単球;糖鎖;モノクローナル抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590389/
• 微生物感染におけるSIGNR1の働き

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  高原 和彦

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  酵母;感染症;糖鎖;レクチン;マクロファージ;単球;樹状細胞;モノクローナル抗体;微生物;TLR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19041036/
• Microbe recognition and effect on TLR response by C-type lection expressing in immune cells.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko TAKAHARA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  レクチン;TLR4;TLR2;グラム陰性菌;Candida albicans;サイトカイン;リボ多糖;マクロファージ;RAW264.7;Zymosan;樹状細胞;TLR;酵母;DC-SIGN, lectin;TLR4;TLR2;macrophage;Gram-negative bacteria;cytokine;Candida albicans;lipopolysaccharide

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590342/
• マウスレクチンSIGNR1の微生物認識およびTLR4との相互作用

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  高原 和彦

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  レクチン;TLR4;リポ多糖;グラム陰性菌;C.albicans;菌糸型;TLR2;マクロファージ;微生物;糖鎖;Toll-like receptor;酵母;CD14

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16017245/
• Microbes and polysaccharide recognition of Langerin

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazuhiko TAKAHARA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  樹状細胞;ランゲリン;ランゲルハンス細胞;C型レクチン;捕捉活性;微生物認識;酵母;グラム陰性菌, Dendritic cells;Langerhans cells;Langerin;C-type lectin;Microbe recognition;C.albicans;zymosan;Phagocytosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590336/
• Function of Dendritic cells as Sentinel and Regulator

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Kayo INABA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  樹状細胞;T細胞活性化;サブセット;免役応答制御;細胞分化;Th1;Th2;抗原捕捉;クロスプレゼンティーション;免疫応答制御;クロスプレゼンテイーション, Dendritic cells;T cell activation;Subsets;Immune regulation;Differentiation;Th1;Th2;Antigen capture;Cross presentation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370075/
• Behavior and function of mouse Langerin^+ cells in skin and mucosa.

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazuhiko TAKAHARA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ランゲルハンス細胞;ランゲリン;FISH;TGF-β;樹状細胞;zymosan;マンナン;C型レクチン;多重体, dendritic cells;Langerhans cells;Langerin;C-type lectin;FISH;mannan;TGF-β;zymosan

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670213/
• 抗腫瘍免疫応答における樹状細胞の役割

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  稲葉 カヨ

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  樹状細胞;細胞亜集団;食作用;死細胞;抗原提示

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13218063/
• 免疫寛容の誘導・維持と破綻における樹状細胞の機能と作用メカニズムの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  稲葉 カヨ

  From 01 Apr. 2001, To 31 Mar. 2006, Project Closed

  樹状細胞;免疫応答制御;制御性T細胞;抗原提示;T細胞活性化;抗原特異性;クロストレランス;クロストプライミング;Th1;Th2;補助刺激分子;免疫寛容;CD25^+CD4^+制御性T細胞;CD80;86;サブセット;抗原捕捉;クロスプレゼンテイーション;T細胞増殖;T細胞除去;IFN-γ;樹状細胞活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13140202/
• 抗原提示細胞によるT細胞活性化機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  稲葉 カヨ

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  樹状細胞;T細胞活性化;サブセット;抗原捕捉;クロスプレゼンテーション;免疫寛容;クロスプレゼンテイーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13037019/
• マウス系統間における皮膚炎症応答の違いとアレルギー獲得性の相関

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  高原 和彦

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ランゲルハンス細胞;アレルギー発症;マトリックス;TGF-β;ランゲリン;樹状細胞;NC;Ngaマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12204062/
• Myeloid dendritic cells and lymphoid dendritic cells

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Kayo INABA

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  樹状細胞;細胞分化;成熟;T細胞活性化;抗原提示;亜集団;表現型;サブセット;ランゲルハンス細胞;ランゲリン;接触過敏応答;IL-12;食作用;アポトーシス;腫瘍細胞;TH1;TH2;免疫制御;単球;MHCクラスII分子;抗原プロセッシング;細胞間相互作用, Dendritic cells;Development;Maturation;T cell activation;Antigen presentation;Subsets;Phenotype

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11470085/
• 炎症領域におけるTGF-β1のランゲルハンス細胞及び樹状細胞に対する影響

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  高原 和彦

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  ランゲルハンス細胞;樹状細胞;皮膚炎症;TGF-β1;BMP-1;PCP;PCPE;マトリックス再構築;Tolloid-like gene

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10770096/

External funds: others

• パターン認識受容体TLRとレクチンの微生物認識における共同作用

  ﾎｸﾄ生物科学振興財団

  From 2006, To 2007

  高原　和彦
• C型レクチンによるC. albicansの認識と免疫制御

  京都大学コアステージバックアップ研究費

  From 2012, To 2012

  高原　和彦
• シリカ粒子によるサイズ依存的なIL-1β産生経路の存在

  清水免疫学・神経科学振興財団研究助成

  From 2013, To 2014

  高原　和彦
• 免疫抑制性サイトカインIL-10産生を誘導する新規糖鎖の開発

  GAPファンドプログラム

  From 01 Dec. 2018, To 30 Nov. 2019

  高原　和彦
• 京都大学ﾘｻｰﾁ･ﾃﾞｨﾍﾞﾛｯﾌﾟﾒﾝﾄﾌﾟﾛｸﾞﾗﾑ 【いしずえ】

  From 2019, To 2019

  高原和彦
• 病原微生物の免疫抑制作用を基にした炎症抑制性糖鎖の開発と応用

  京都大学教育研究振興財団、研究活動推進助成

  From 2019, To 2020

  高原和彦
• 自然免疫レセプターDectin-1は個体最初のT細胞発生に必須である

  清水免疫学・神経科学振興財団研究助成

  From 2020, To 2021

  高原　和彦
• 橋渡し研究戦略的推進プログラム 異分野融合型研究開発推進支援事業 支援課題(異分野融合型研究シーズ)

  From 01 Apr. 2021, To 31 Mar. 2022

  高原　和彦
• マウスマクロファージ/DCサブセットの応答における均衡維持機構

  CREST

  From 2008, To 2013

  分担

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Immunology and Human Disorders

  1031, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Special Study CourseII(Biological Sciences) 7

  8710, Year-long, Faculty of Science, 12
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory work in Biological Science D

  3765, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunobiology

  3722, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunobiology

  3722, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminars in Biological Science B

  4732, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Immunology and Human Disorders

  1031, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory work in Biological Science D

  3765, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Biology and Life Science

  N484, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Study CourseII(Biological Sciences) 7

  8710, Year-long, Faculty of Science, 12
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From Apr. 2011, To Mar. 2012

  免疫生物学

  Spring, 理学部
• From Apr. 2011, To Mar. 2012

  生物学実習Ｄ　（２）

  Fall, 理学部
• From Apr. 2011, To Mar. 2012

  生物学セミナ－Ｂ　（５）

  Fall, 理学部
• From Apr. 2011, To Mar. 2012

  生物科学課題研究７

  Year-long, 理学部
• From Apr. 2012, To Mar. 2013

  Immunobiology

  Spring, 理学部
• From Apr. 2012, To Mar. 2013

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2012, To Mar. 2013

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2012, To Mar. 2013

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2013, To Mar. 2014

  Immunobiology

  Spring, 理学部
• From Apr. 2013, To Mar. 2014

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2013, To Mar. 2014

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2013, To Mar. 2014

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2013, To Mar. 2014

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Study of Life Science II

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Immunobiology

  Spring, 理学部
• From Apr. 2014, To Mar. 2015

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2014, To Mar. 2015

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2014, To Mar. 2015

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2014, To Mar. 2015

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Study of Life Science II

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Immunobiology

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2015, To Mar. 2016

  Study of Life Science II

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2015, To Mar. 2016

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2015, To Mar. 2016

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2015, To Mar. 2016

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Immunobiology

  Spring, 理学部
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2016, To Mar. 2017

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2016, To Mar. 2017

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Immunobiology

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2017, To Mar. 2018

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2017, To Mar. 2018

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Immunobiology

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2018, To Mar. 2019

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2018, To Mar. 2019

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Immunobiology

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2019, To Mar. 2020

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Laboratory work in Biological Science D

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2019, To Mar. 2020

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Immunobiology

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2020, To Mar. 2021

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Laboratory Work in Biological Science D

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2020, To Mar. 2021

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Immunobiology

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Self-defense mechanisms

  Spring, 総合生存学館
• From Apr. 2021, To Mar. 2022

  Seminars in Biological Science B

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Laboratory Work in Biological Science D

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Special Study CourseII(Biological Sciences) 7

  Year-long, 理学部
• From Apr. 2021, To Mar. 2022

  Advanced Course in Immunology and Human Disorders

  Spring, 生命科学研究科

Administration

School management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  京都大学教務事務電算管理運営委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2017

  京都大学教務事務電算管理運営委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2015

  環境管理専門委員会有機廃液情報管理小委員会　委員
• From 01 Oct. 2014, To 30 Sep. 2016

  京都大学動物実験委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2019

  京都大学教務事務電算管理運営委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  環境管理専門委員会有機廃液情報管理小委員会委員
• From 01 Apr. 2019, To 31 Mar. 2021

  京都大学教務事務電算管理運営委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  京都大学教務事務電算管理運営委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  化学物質専門委員会 委員

Faculty management (title, position)

• From 01 Apr. 2022

  安全・環境保全委員会
• From 01 Apr. 2022

  衛生管理者
• From 01 Apr. 2003

  図書委員会委員
• From 01 Apr. 2016, To 31 Mar. 2021

  安全・環境保全委員会委員
• From 01 Oct. 2015

  データ保全委員会委員
• From 01 Apr. 2017, To 31 Mar. 2021

  化学物質管理小委員会委員
• From 08 Feb. 2007

  特別管理産業廃棄物管理責任者
• From 01 Apr. 2019

  SPFマウス実験室運営委員会委員
• From 01 Apr. 2019

  SPFマウス実験室管理委員会委員
• From 01 Apr. 2020, To 31 Mar. 2021

  衛生管理者
• From 01 Apr. 2021

  化学物質管理小委員会　委員長