Basic Information

Faculty

• 農学部

Concurrent Affiliation

• Graduate School of Agriculture, 応用生命科学専攻 応用生化学講座, 協力教員（教授）

Email Address

• Email Address

  ueda.kazumitsu.7wkyoto-u.ac.jp

Professional Memberships

• 日本分子生物学会
• 米国癌学会 (AMERICAN ASSOCIATION FOR CANCER RESEARCH)
• 日本生化学会
• 日本癌学会
• 日本農芸化学会

Academic Degree

• 農学修士(京都大学)
• 農学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院農学研究科修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 農学部農芸化学科, 卒業

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0003-2980-6078

• J-Global ID

  200901098095256188

• External link

  https://www.icems.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/read0013041

Research

Research Topics, Overview of the research

• Research Topics

  Molecular mechanism of ABC proteins
  Mechanism of HDL formation

• Overview of the research

  Our body is made of 60 trillion cells and hundreds of billions of the cells die and are renewed with fresh ones every day. The fresh cells are constructed by using amino acids, carbohydrates and lipids contained in daily diet. Meat, grains and other food are digested, and the nutrients are absorbed from intestine. They are first delivered to liver and then transported to all the body cells to be used as materials for the cells. To maintain our life and health, absorbed nutrients should be transported properly via bloodstream to all the body cells.
  
  Cholesterol, one of lipids, is also a very important nutrient to construct cells. However, it has a bad reputation, because its over-accumulation destroys cells. Buildup of dead cells, in which cholesterol is over-accumulated, in artery wall hampers blood flow and causes atherosclerosis.
  
  Cholesterol is delivered from liver to all the body cells through bloodstream as LDL particles, so-called bad cholesterol, and excess cholesterol in body cells are reversely transported to liver through bloodstream as HDL particles, so-called good cholesterol. While both LDL and HDL particles are necessary for us, people with high LDL in blood have high risk of atherosclerosis. It is why LDL particles are called bad cholesterol.
  
  30 years ago, we discovered the mechanism by which lipophilic compounds are transported in our body for the first time. When our body has some defects in transporting lipophilic compounds including cholesterol, we suffer from various diseases, such as atherosclerosis, Alzheimer’s disease, skin diseases, eye diseases.
  
  Ueda group is trying to reveal the mechanism of lipid transport and HDL generation and to find ways to prevent and cure various diseases which trouble us.
  

Research Interests

• 分子生物学
• 癌化学療法
• 応用分子細胞生物学
• Molecular Biology
• Cancer Chemotherapy
• Applied Molecular Cell Biology

Research Areas

• Life sciences, Applied molecular and cellular biology
• Life sciences, Molecular biology

Papers

• ABCA1-mediated nascent HDL formation is precisely regulated by the plasma membrane cholesterol

  Fumihiko Ogasawara; Kazumitsu Ueda

  Journal of Lipid Research, Mar. 2025

  
• Successful utilization of coronary covered stents to treat a common hepatic artery pseudoaneurysm secondary to pancreatic fistula after Whipple's procedure: report of a case.

  Sasaki K; Ueda K; Nishiyama A; Yoshida K; Sako A; Sato M; Okumura M

  2009

  
• [Structures and functions of xenobiotic efflux pump P-glycoprotein and MRP--important molecular targets for cancer chemotherapy]

  Ueda K

  Dec. 1997

  
• [Multidrug resistance of cancer cells mediated by ABC superfamily transporters].

  Ueda K

  May 1997

  
• ABCA1 and cholesterol transfer protein Aster-A promote an asymmetric cholesterol distribution in the plasma membrane

  Fumihiko Ogasawara; Kazumitsu Ueda

  Journal of Biological Chemistry, Dec. 2022

  Access this paper :

  
• Targeted deletion of ecto-5′-nucleotidase results in retention of inosine monophosphate content in postmortem muscle of medaka (Oryzias latipes)

  Yu Murakami; Masashi Ando; Ryota Futamata; Tomohisa Horibe; Kazumitsu Ueda; Masato Kinoshita; Toru Kobayashi

  Scientific Reports, 03 Nov. 2022

  
• DNA damage caused by ascorbate in the presence of Cu2+ induces mutations.

  S. Kobayashi; K. Yoshida; K. Ueda; H. Sakai; T. Komano

  Nucleic acids symposium series, 1988

  
• The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids

  Kazuki Sakata; Noriyuki Kioka; Kazumitsu Ueda; Yasuhisa Kimura

  The Journal of Biochemistry, 31 May 2024

  
• 脂質輸送とABCタンパク質 ABC1サブファミリーに属するABC2の単離と組織発現

  稲垣 暢也; 周 成基; 田中 亜路; 中田 正範; 平林 敬浩; 天知 輝夫; 塩田 清二; 植田 和光; 趙 麗霞

  生化学, Aug. 2000

  
• SUBSTRATES FOR P-GLYCOPROTEIN IN KIDNEY

  R HORI; Y TANIGAWARA; M HIRAI; M YASUHARA; K UEDA; T KOMANO

  TRANSPORT IN THE LIVER, 1994, Peer-reviewed

  
• ゼネラルモータース癌研究財団国際シンポジウム"抗癌剤耐性:分子メカニズムと臨床への応用"

  植田 和光

  日本農芸化学会誌, 1993

  
• 31 治療前後で樹立した神経芽腫株における薬剤感受性とmdr-1 gene の関連性

  黒田 啓史; 杉本 徹; 堀井 由博; 松村 隆文; 沢田 淳; 植田 和光

  日本小児外科学会雑誌, 1988

  
• The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains.

  Hiroshi Tachibana; Kodai Minoura; Tomohiro Omachi; Kohjiro Nagao; Takafumi Ichikawa; Yasuhisa Kimura; Nozomu Kono; Yuta Shimanaka; Hiroyuki Arai; Kazumitsu Ueda; Noriyuki Kioka

  Journal of cell science, 15 Aug. 2023

  
• Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a Japanese medaka (Oryzias latipes)

  Ryota Futamata; Masato Kinoshita; Katsueki Ogiwara; Noriyuki Kioka; Kazumitsu Ueda

  Heliyon, Feb. 2023

  Access this paper :

  
• The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Atsushi Kodan; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  bioRxiv, Nov. 2019

  
• Function of ABCA1 and ABCG1 in Cholesterol Homeostasis

  MATSUO Michinori; UEDA Kazumitsu

  MEMBRANE, 01 Sep. 2007

  
• ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs.

  Atsushi Kodan; Ryota Futamata; Yasuhisa Kimura; Noriyuki Kioka; Toru Nakatsu; Hiroaki Kato; Kazumitsu Ueda

  FEBS letters, Mar. 2021

  
• Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein.

  Ryota Futamata; Noriyuki Kioka; Kazumitsu Ueda

  Bio-protocol, 20 Feb. 2021

  
• ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking

  Mitsuhiro Nakato; Naoko Shiranaga; Maiko Tomioka; Hitomi Watanabe; Junko Kurisu; Mineko Kengaku; Naoko Komura; Hiromune Ando; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Journal of Biological Chemistry, 2021

  Access this paper :

  
• Structural and functional diversity calls for a new classification of ABC transporters.

  Christoph Thomas; Stephen G Aller; Konstantinos Beis; Elisabeth P Carpenter; Geoffrey Chang; Lei Chen; Elie Dassa; Michael Dean; Franck Duong Van Hoa; Damian Ekiert; Robert Ford; Rachelle Gaudet; Xin Gong; I Barry Holland; Yihua Huang; Daniel K Kahne; Hiroaki Kato; Vassilis Koronakis; Christopher M Koth; Youngsook Lee; Oded Lewinson; Roland Lill; Enrico Martinoia; Satoshi Murakami; Heather W Pinkett; Bert Poolman; Daniel Rosenbaum; Balazs Sarkadi; Lutz Schmitt; Erwin Schneider; Yigong Shi; Show-Ling Shyng; Dirk J Slotboom; Emad Tajkhorshid; D Peter Tieleman; Kazumitsu Ueda; András Váradi; Po-Chao Wen; Nieng Yan; Peng Zhang; Hongjin Zheng; Jochen Zimmer; Robert Tampé

  FEBS letters, Dec. 2020

  
• ABC proteins in evolution.

  Fumihiko Ogasawara; Atsushi Kodan; Kazumitsu Ueda

  FEBS letters, Dec. 2020

  
• Stiffness of the extracellular matrix regulates differentiation into beige adipocytes.

  Kyoko Takata; Tsuyoshi Goto; Mito Kuroda; Yasuhisa Kimura; Ichiro Harada; Kazumitsu Ueda; Teruo Kawada; Noriyuki Kioka

  Biochemical and biophysical research communications, 05 Nov. 2020

  
• In vivo FRET analyses reveal a role of ATP hydrolysis–associated conformational changes in human P-glycoprotein

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Atsushi Kodan; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Journal of Biological Chemistry, 10 Apr. 2020, Peer-reviewed

  Access this paper :

  
• Cholesterol asymmetry at the tip of filopodia during cell adhesion.

  Takuma Kishimoto; Nario Tomishige; Motohide Murate; Reiko Ishitsuka; Hubert Schaller; Yves Mély; Kazumitsu Ueda; Toshihide Kobayashi

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 12 Mar. 2020, Peer-reviewed

  
• C-terminal of ABCA1 separately regulates cholesterol floppase activity and cholesterol efflux activity

  Kazumitsu Ueda

  Bioscience, Biotechnology, and Biochemistry, 02 Apr. 2020, Peer-reviewed

  
• Phosphorylation by protein kinase C stabilizes ABCG1 and increases cholesterol efflux.

  Watanabe T; Kioka N; Ueda K; Matsuo M

  Journal of biochemistry, May 2019, Peer-reviewed

  
• How ATP is used by P-glycoprotein to export multiple hydrophobic compounds

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  May 2019

  
• Cell migration is negatively modulated by ABCA1.

  Ito S; Kioka N; Ueda K

  Biosci Biotechnol Biochem, Mar. 2019, Peer-reviewed

  
• Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1

  Kazumitsu Ueda

  Bioscience, Biotechnology, and Biochemistry, 04 Mar. 2019, Peer-reviewed

  
• Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation

  Fumihiko Ogasawara; Fumi Kano; Masayuki Murata; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Scientific Reports, 14 Mar. 2019, Peer-reviewed

  Access this paper :

  
• An amphipathic helix of vinexin &[alpha] is necessary for substrate stiffness-dependent conformational change in vinculin.

  Hino N; Ichikawa T; Kimura Y; Matsuda M; Ueda K; Kioka N

  Journal of Cell Science, 2019, Peer-reviewed

  
• Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.

  Kodan A; Yamaguchi T; Nakatsu T; Matsuoka K; Kimura Y; Ueda K; Kato H

  Nature Communications, Jan. 2019, Peer-reviewed

  Access this paper :

  
• Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation

  Masato Ishigami; Fumihiko Ogasawara; Kohjiro Nagao; Hidehiko Hashimoto; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

  Access this paper :

  
• Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

  Ana Perea; José Ignacio Manzano; Yasuhisa Kimura; Kazumitsu Ueda; Santiago Castanys; Francisco Gamarro

  Biochemical Journal, 15 Jan. 2018, Peer-reviewed

  
• Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells.

  Kuroda M; Ueda K; Kioka N

  Scientific Reports, 2018, Peer-reviewed

  Access this paper :

  
• Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation

  Takafumi Ichikawa; Masahiro Kita; Tsubasa S. Matsui; Ayaka Ichikawa Nagasato; Tomohiko Araki; Shian-Huey Chiang; Takuhito Sezaki; Yasuhisa Kimura; Kazumitsu Ueda; Shinji Deguchi; Alan R. Saltiel; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, Oct. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7.

  Tomioka M; Toda Y; Mañucat NB; Akatsu H; Fukumoto M; Kono N; Arai H; Kioka N; Ueda K

  Biochimica et biophysica acta, Jul. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7.

  Tomioka M; Toda Y; Mañucat NB; Akatsu H; Fukumoto M; Kono N; Arai H; Kioka N; Ueda K

  Biochimica et biophysica acta. Molecular and cell biology of lipids, Jul. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7

  Maiko Tomioka; Yoshinobu Toda; Noralyn B. Manucat; Hiroyasu Akatsu; Manabu Fukumoto; Nozomu Kono; Hiroyuki Arai; Noriyuki Kioka; Kazumitsu Ueda

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jul. 2017, Peer-reviewed

  
• Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behaviore

  Tomohiro Omachi; Takafumi Ichikawa; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  PLOS ONE, Apr. 2017, Peer-reviewed

  Access this paper :

  
• Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes

  Mito Kuroda; Hiroki Wada; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, Mar. 2017, Peer-reviewed

  
• Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

  Shu-Lin Liu; Ren Sheng; Jae Hun Jung; Li Wang; Ewa Stec; Matthew J. O'Connor; Seohyoen Song; Rama Kamesh Bikkavilli; Robert A. Winn; Daesung Lee; Kwanghee Baek; Kazumitsu Ueda; Irena Levitan; Kwang-Pyo Kim; Wonhwa Cho

  NATURE CHEMICAL BIOLOGY, Mar. 2017, Peer-reviewed

  
• A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures

  Di Mao; Shin Ando; Shin-ichi Sato; Ying Qin; Nao Hirata; Yousuke Katsuda; Eihachiro Kawase; Ting-Fang Kuo; Itsunari Minami; Yuji Shiba; Kazumitsu Ueda; Norio Nakatsuji; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2017, Peer-reviewed

  
• Celebrating Dr. Satoshi mura, the recipient of the 2015 Nobel Prize in Physiology or Medicine: Agricultural chemistry, ivermectin, and MDR1

  Kazumitsu Ueda

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 2017, Peer-reviewed

  
• The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix

  Ayaka Ichikawa Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, Peer-reviewed

  
• Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport

  Ken-ichi Miyata; Yoshiaki Nakagawa; Yasuhisa Kimura; Kazumitsu Ueda; Miki Akamatsu

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2016, Peer-reviewed

  
• ビネキシンαの両親媒性ヘリックスはテーリンと協調的にビンキュリンと相互作用する

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本細胞生物学会大会講演要旨集, May 2016, Peer-reviewed

  
• ABCG1 and ABCG4 Suppress gamma-Secretase Activity and Amyloid beta Production

  Osamu Sano; Maki Tsujita; Yuji Shimizu; Reiko Kato; Aya Kobayashi; Noriyuki Kioka; Alan T. Remaley; Makoto Michikawa; Kazumitsu Ueda; Michinori Matsuo

  PLOS ONE, May 2016, Peer-reviewed

  Access this paper :

  
• In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines

  Ken-ichi Miyata; Yoshiaki Nakagawa; Yasuhisa Kimura; Kazumitsu Ueda; Miki Akamatsu

  TOXICOLOGY AND APPLIED PHARMACOLOGY, May 2016, Peer-reviewed

  
• 接着斑タンパク質ビネキシンαの両親媒性へリックスはビンキュリンの構造変化を引き起こすために必要である

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Peer-reviewed

  
• Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells

  Mitsuhiro Nakato; Michinori Matsuo; Nozomu Kono; Makoto Arita; Hiroyuki Arai; Jun Ogawa; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Oct. 2015, Peer-reviewed

  
• Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum

  Yoshio Yamauchi; Noriyuki Iwamoto; Maximillian A. Rogers; Sumiko Abe-Dohmae; Toyoshi Fujimoto; Catherine C. Y. Chang; Masato Ishigami; Takuma Kishimoto; Toshihide Kobayashi; Kazumitsu Ueda; Koichi Furukawa; Ta-Yuan Chang; Shinji Yokoyama

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2015, Peer-reviewed

  
• ビネキシンαの両親媒性ヘリックスはビンキュリンの頭部と相互作用する

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本細胞生物学会大会講演要旨集, Jun. 2015, Peer-reviewed

  
• Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1

  Shimpei Itoh; Kohjiro Nagao; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2015, Peer-reviewed

  
• ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner

  Yu Zhao; Masato Ishigami; Kohjiro Nagao; Kentaro Hanada; Nozomu Kono; Hiroyuki Arai; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Mar. 2015, Peer-reviewed

  
• Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation

  L. Tomiyama; T. Sezaki; M. Matsuo; K. Ueda; N. Kioka

  Oncogene, 26 Feb. 2015, Peer-reviewed

  
• Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe

  Tomohiro Chiba; Tsuyoshi Sakurada; Rie Watanabe; Kohji Yamaguchi; Yasuhisa Kimura; Noriyuki Kioka; Hirokazu Kawagishi; Michinori Matsuo; Kazumitsu Ueda

  PLOS ONE, Dec. 2014, Peer-reviewed

  
• Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I

  Risa Omura; Kohjiro Nagao; Norihiro Kobayashi; Kazumitsu Ueda; Hiroyuki Saito

  JOURNAL OF LIPID RESEARCH, Nov. 2014, Peer-reviewed

  
• ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane

  Osamu Sano; Shiho Ito; Reiko Kato; Yuji Shimizu; Aya Kobayashi; Yasuhisa Kimura; Noriyuki Kioka; Kentaro Hanada; Kazumitsu Ueda; Michinori Matsuo

  PLOS ONE, Oct. 2014, Peer-reviewed

  
• Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative

  Ting-Fang Kuo; Di Mao; Nao Hirata; Bilon Khambu; Yasuhisa Kimura; Eihachiro Kawase; Hiroki Shimogawa; Makoto Ojika; Norio Nakatsuji; Kazumitsu Ueda; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2014, Peer-reviewed

  
• The role of the interaction of the vinculin proline-rich linker region with vinexin alpha in sensing the stiffness of the extracellular matrix

  Hiroshi Yamashita; Takafumi Ichikawa; Daisuke Matsuyama; Yasuhisa Kimura; Kazumitsu Ueda; Susan W. Craig; Ichiro Harada; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, May 2014, Peer-reviewed

  
• Erratum to Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals [J. Pestic. Sci., 38, 3, (2013), 112-122] DOI: 10.1584/jpestics.D13-022

  Satoshi Kanaoka; Yasuhisa Kimura; Masaaki Fujikawa; Yoshiaki Nakagawa; Kazumitsu Ueda; Miki Akamatsu

  Journal of Pesticide Science, 06 Mar. 2014

  
• A Chemical Probe that Labels Human Pluripotent Stem Cells

  Nao Hirata; Masato Nakagawa; Yuto Fujibayashi; Kaori Yamauchi; Asako Murata; Itsunari Minami; Maiko Tomioka; Takayuki Kondo; Ting-Fang Kuo; Hiroshi Endo; Haruhisa Inoue; Shin-ichi Sato; Shin Ando; Yoshinori Kawazoe; Kazuhiro Aiba; Koh Nagata; Eihachiro Kawase; Young-Tae Chang; Hirofumi Suemori; Koji Eto; Hiromitsu Nakauchi; Shinya Yamanaka; Norio Nakatsuji; Kazumitsu Ueda; Motonari Uesugi

  CELL REPORTS, Mar. 2014, Peer-reviewed

  Access this paper :

  
• Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Sakiyama; Christopher J. Hipolito; Akane Fujioka; Ryo Hirokane; Keiji Ikeguchi; Bunta Watanabe; Jun Hiratake; Yasuhisa Kimura; Hiroaki Suga; Kazumitsu Ueda; Hiroaki Kato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2014, Peer-reviewed

  
• Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

  Shigenobu Kishino; Michiki Takeuchi; Si-Bum Park; Akiko Hirata; Nahoko Kitamura; Jun Kunisawa; Hiroshi Kiyono; Ryo Iwamoto; Yosuke Isobe; Makoto Arita; Hiroyuki Arai; Kazumitsu Ueda; Jun Shima; Satomi Takahashi; Kenzo Yokozeki; Sakayu Shimizu; Jun Ogawa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2013, Peer-reviewed

  Access this paper :

  
• Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport

  Nobukazu Shitan; Fabien Dalmas; Kazuyuki Dan; Nobuhiko Kato; Kazumitsu Ueda; Fumihiko Sato; Cyrille Forestier; Kazufumi Yazaki

  PHYTOCHEMISTRY, Jul. 2013, Peer-reviewed

  Access this paper :

  
• Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

  Naohiro Takemoto; Tetsuya Suehara; Heidie L. Frisco; Shin-ichi Sato; Takuhito Sezaki; Kosuke Kusamori; Yoshinori Kawazoe; Sun Min Park; Sayumi Yamazoe; Yoshiyuki Mizuhata; Rintaro Inoue; Gavin J. Miller; Steen U. Hansen; Gordon C. Jayson; John M. Gardiner; Toshiji Kanaya; Norihiro Tokitoh; Kazumitsu Ueda; Yoshinobu Takakura; Noriyuki Kioka; Makiya Nishikawa; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed

  
• 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1

  Akihiro Matsuda; Kohjiro Nagao; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  Journal of Neurochemistry, Jul. 2013, Peer-reviewed

  
• Dlg5 interacts with the TGF-β receptor and promotes its degradation

  Takuhito Sezaki; Lucia Tomiyama; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  FEBS Letters, 05 Jun. 2013, Peer-reviewed

  Access this paper :

  
• ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1.

  Ishigami M; Tominaga Y; Nagao K; Kimura Y; Matsuo M; Kioka N; Ueda K

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Apr. 2013, Peer-reviewed

  
• ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1

  Masato Ishigami; Yuko Tominaga; Kohjiro Nagao; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Apr. 2013

  
• ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging

  Koh O. Nagata; Chieko Nakada; Rinshi S. Kasai; Akihiro Kusumi; Kazumitsu Ueda

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2013, Peer-reviewed

  
• ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin

  Hiroshi Hirayama; Yasuhisa Kimura; Noriyuki Kioka; Michinori Matsuo; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Feb. 2013, Peer-reviewed

  
• Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding.

  Nagao K; Maeda M; Mañucat NB; Ueda K

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Feb. 2013, Peer-reviewed

  
• Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding

  Kohjiro Nagao; Minami Maeda; Noralyn B. Manucat; Kazumitsu Ueda

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Feb. 2013, Peer-reviewed

  
• オメガ３脂肪酸含有油脂の微生物による生産と変換

  櫻谷英治; 岸野重信; 安藤晃規; 新井洋由; 植田和光; 小川 順

  BIOINDUSTRY, Feb. 2013

  
• Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agro chemicals

  Satoshi Kanaoka; Yasuhisa Kimura; Masaaki Fujikawa; Yoshiaki Nakagawa; Kazumitsu Ueda; Miki Akamatsu

  JOURNAL OF PESTICIDE SCIENCE, 2013, Peer-reviewed

  
• オメガ３脂肪酸-より良い脂質バランスを実現するための機能解析と製品・生産法開発-

  小川 順; 新井洋由; 植田和光

  BIOINDUSTRY, 2013

  
• The Effects of Neurological Disorder-Related Codon Variations of ABCA13 on the Function of the ABC Protein

  Maiko Tomioka; Yoshinobu Toda; Junko Kurisu; Yasuhisa Kimura; Mineko Kengaku; Kazumitsu Ueda

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Dec. 2012, Peer-reviewed

  
• Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex

  Sabine Hulpke; Maiko Tomioka; Elisabeth Kremmer; Kazumitsu Ueda; Rupert Abele; Robert Tampe

  CELLULAR AND MOLECULAR LIFE SCIENCES, Oct. 2012, Peer-reviewed

  
• Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate Kinase Family Protein, in Epithelial-Mesenchymal Transition in LLc-PK1 Renal Epithelial Cells

  Takuhito Sezaki; Kohki Inada; Takayuki Sogabe; Kumiyo Kakuda; Lucia Tomiyama; Yohsuke Matsuno; Takafumi Ichikawa; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  PLOS ONE, Apr. 2012, Peer-reviewed

  Access this paper :

  
• Lysine residues of ABCA1 are required for the interaction with apoA-I.

  Nagao K; Kimura Y; Ueda K

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Mar. 2012, Peer-reviewed

  
• Lysine residues of ABCA1 are required for the interaction with apoA-I

  Kohjiro Nagao; Yasuhisa Kimura; Kazumitsu Ueda

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Mar. 2012

  
• ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding

  Kohjiro Nagao; Kei Takahashi; Yuya Azuma; Mie Takada; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Jan. 2012, Peer-reviewed

  
• Function and regulation of ABCA1-membrane meso-domain organization and reorganization

  Kohjiro Nagao; Maiko Tomioka; Kazumitsu Ueda

  FEBS JOURNAL, Sep. 2011, Peer-reviewed

  
• Liver X Receptor beta (LXR beta) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation

  Masako Hozoji-Inada; Youichi Munehira; Kohjiro Nagao; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• Liver X Receptor beta (LXR beta) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation

  Masako Hozoji-Inada; Youichi Munehira; Kohjiro Nagao; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• ABC Proteins Protect the Human Body and Maintain Optimal Health

  Kazumitsu Ueda

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Mar. 2011, Peer-reviewed

  Access this paper :

  
• WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions

  Hiroshi Yamashita; Kazumitsu Ueda; Noriyuki Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2011, Peer-reviewed

  
• WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions

  Hiroshi Yamashita; Kazumitsu Ueda; Noriyuki Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2011, Peer-reviewed

  
• Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins.

  Matsuo M; Campenot RB; Vance DE; Ueda K; Vance JE

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Jan. 2011, Peer-reviewed

  
• ABCA1-mediated HDL formation: Mechanism and regulation

  Kohjiro Nagao; Masako Hozoji-Inada; Yuya Azuma; Kazumitsu Ueda

  The ABC Transporters of Human Physiology and Disease: Genetics and Biochemistry of ATP Binding Cassette Transporters, 01 Jan. 2011, Peer-reviewed

  
• Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins

  Michinori Matsuo; Robert B. Campenot; Dennis E. Vance; Kazumitsu Ueda; Jean E. Vance

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jan. 2011, Peer-reviewed

  
• Lipid outward translocation by ABC proteins

  Kohjiro Nagao; Yasuhisa Kimura; Michinori Mastuo; Kazumitsu Ueda

  FEBS LETTERS, Jul. 2010, Peer-reviewed

  Access this paper :

  
• Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo

  Noriyuki Kioka; Takuya Ito; Hiroshi Yamashita; Natsuko Uekawa; Tsutomu Umemoto; Soh Motoyoshi; Hiroshi Imai; Kenzo Takahashi; Hideto Watanabe; Masayasu Yamada; Kazumitsu Ueda

  EXPERIMENTAL CELL RESEARCH, Jun. 2010, Peer-reviewed

  Access this paper :

  
• ATP-Binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion

  Mototada Shichiri; Yasukazu Takanezawa; Daisy E. Rotzoll; Yasukazu Yoshida; Tomokuni Kokubu; Kazumitsu Ueda; Hiroshi Tamai; Hiroyuki Arai

  JOURNAL OF NUTRITIONAL BIOCHEMISTRY, May 2010, Peer-reviewed

  
• Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP

  Kanako Terakado; Atsushi Kodan; Hiroaki Nakano; Yasuhisa Kimura; Kazumitsu Ueda; Toru Nakatsu; Hiroaki Kato

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Mar. 2010, Peer-reviewed

  
• Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin

  Tsutomu Umemoto; Kana Tanaka; Kazumitsu Ueda; Noriyuki Kioka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, Peer-reviewed

  
• Enzymatic measurement of phosphatidic acid in cultured cells

  Shin-ya Morita; Kazumitsu Ueda; Shuji Kitagawa

  JOURNAL OF LIPID RESEARCH, Sep. 2009, Peer-reviewed

  
• A novel missense mutation of ABCA1 in transmembrane α-helix in a Japanese patient with Tangier disease

  Mizuho Maekawa; Jiro Kikuchi; Kazuhiko Kotani; Kohjiro Nagao; Tsogbadrakh Odgerel; Kazumitsu Ueda; Mikihiko Kawano; Yusuke Furukawa; Ikunosuke Sakurabayashi

  Atherosclerosis, Sep. 2009, Peer-reviewed

  
• A novel missense mutation of ABCA1 in transmembrane alpha-helix in a Japanese patient with Tangier disease

  Mizuho Maekawa; Jiro Kikuchi; Kazuhiko Kotani; Kohjiro Nagao; Tsogbadrakh Odgerel; Kazumitsu Ueda; Mikihiko Kawano; Yusuke Furukawa; Ikunosuke Sakurabayashi

  ATHEROSCLEROSIS, Sep. 2009, Peer-reviewed

  
• Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells

  Atsushi Kodan; Hiroyuki Shibata; Takashi Matsumoto; Kanako Terakado; Keita Sakiyama; Michinori Matsuo; Kazumitsu Ueda; Hiroaki Kato

  PROTEIN EXPRESSION AND PURIFICATION, Jul. 2009, Peer-reviewed

  
• Mutational Analysis of Uncharged Polar Residues and Proline in the Distal One-Third (Thr(130)-Pro(142)) of the Highly Conserved Region of Mouse Slc10a2

  Tohru Saeki; Satoko Mizushima; Kazumitsu Ueda; Kimikazu Iwami; Ryuhei Kanamoto

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2009, Peer-reviewed

  
• Functional role of the linker region in purified human P-glycoprotein

  Tomomi Sato; Atsushi Kodan; Yasuhisa Kimura; Kazumitsu Ueda; Toru Nakatsu; Hiroaki Kato

  FEBS JOURNAL, Jul. 2009, Peer-reviewed

  
• v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin

  Tsutomu Umemoto; Takahiro Inomoto; Kazumitsu Ueda; Michinari Hamaguchi; Noriyuki Kioka

  CANCER LETTERS, Jun. 2009, Peer-reviewed

  
• Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation

  Kohjiro Nagao; Yu Zhao; Kei Takahashi; Yasuhisa Kimura; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Jun. 2009, Peer-reviewed

  
• Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1

  Masako Hozoji; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2009, Peer-reviewed

  
• The COP9 signalosome controls ubiquitinylation of ABCA1

  Yuya Azuma; Mie Takada; Minami Maeda; Noriyuki Kioka; Kazumitsu Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2009, Peer-reviewed

  
• Molecular Mechanisms of Subcellular Localization of ABCG5 and ABCG8

  Takashi Hirata; Morio Okabe; Aya Kobayashi; Kazumitsu Ueda; Michinori Matsuo

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Mar. 2009, Peer-reviewed

  
• Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation

  Yuya Azuma; Mie Takada; Hye-Won Shin; Noriyuki Kioka; Kazuhisa Nakayama; Kazumitsu Ueda

  GENES TO CELLS, Feb. 2009, Peer-reviewed

  
• ABCタンパク質の機能と輸送メカニズム 薬物トランスポーター活用ライブラリー（乾 賢一編）

  木村泰久; 植田和光

  羊土社 122-130, 2009

  
• Direct Interaction of Nuclear Liver X Receptor-beta with ABCA1 Modulates Cholesterol Efflux

  Masako Hozoji; Youichi Munehira; Yuika Ikeda; Makoto Makishima; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2008, Peer-reviewed

  
• Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1

  Arowu R. Tanaka; Fumi Kano; Akitsugu Yamamoto; Kazumitsu Ueda; Masayuki Murata

  GENES TO CELLS, Aug. 2008, Peer-reviewed

  
• The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress

  Arowu R. Tanaka; Fumi Kano; Kazumitsu Ueda; Masayuki Murata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2008, Peer-reviewed

  
• ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier

  Shin-Ichi Akanuma; Sumio Ohtsuki; Youko Doi; Masanori Tachikawa; Shingo Ito; Satoko Hori; Tomoko Asashima; Tadafumi Hashimoto; Kaoru Yamada; Kazumitsu Ueda; Takeshi Iwatsubo; Tetsuya Terasaki

  NEUROCHEMISTRY INTERNATIONAL, May 2008, Peer-reviewed

  
• Cholesterol fill-in model: mechanism for substrate recognition by ABC proteins

  Yasuhisa Kimura; Atsushi Kodan; Michinori Matsuo; Kazumitsu Ueda

  JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, Dec. 2007, Peer-reviewed

  
• Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1

  Osamu Sano; Aya Kobayashi; Kohjiro Nagao; Keigo Kumagai; Noriyuki Kioka; Kentaro Hanada; Kazumitsu Ueda; Michinori Matsuo

  JOURNAL OF LIPID RESEARCH, Nov. 2007, Peer-reviewed

  
• Mechanism of multidrug recognition by MDR1/ABCB1

  Yasuhisa Kimura; Shin-ya Morita; Michinori Matsuo; Kazumitsu Ueda

  CANCER SCIENCE, Sep. 2007, Peer-reviewed

  
• Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters

  Shizuko Tachibana; Maki Hirano; Takashi Hirata; Michinori Matsuo; Ikuo Ikeda; Kazumitsu Ueda; Ryuichiro Sato

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2007, Peer-reviewed

  
• Effects of ala substitution for conserved Cys residues in mouse ileal and hepatic Na+-dependent bile acid transporters

  Tohru Saeki; Yuki Munetaka; Kazurnitsu Ueda; Kimikazu Iwami; Ryuhei Kanamoto

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2007, Peer-reviewed

  
• Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

  Shin-ya Morita; Aya Kobayashi; Yasukazu Takanezawa; Noriyuki Kioka; Tetsurou Handa; Hiroyuki Arai; Michinori Matsuo; Kazumitsu Ueda

  HEPATOLOGY, Jul. 2007, Peer-reviewed

  
• Enhanced ApoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient chinese hamster ovary cells

  Kohjiro Nagao; Kei Takahashi; Kentaro Hanada; Noriyuki Kioka; Michinori Matsuo; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2007, Peer-reviewed

  
• Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation

  Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  EXPERIMENTAL CELL RESEARCH, May 2007, Peer-reviewed

  
• Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

  Yasuhisa Kimura; Noriyuki Kioka; Hiroaki Kato; Michinori Matsuo; Kazumitsu Ueda

  BIOCHEMICAL JOURNAL, Jan. 2007, Peer-reviewed

  
• Human MDR1 and MRP1 recognize berberine as their transport substrate

  Nobukazu Shitan; Miyako Tanaka; Koichiro Terai; Kazumitsu Ueda; Kazufumi Yazaki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 2007, Peer-reviewed

  
• Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency

  Yoshihiro Matsumura; Nobuhiro Ban; Kazumitsu Ueda; Nobuya Inagaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2006, Peer-reviewed

  
• Future drug discovery owing to structure analysis of the ABC(ATP-bindingcassette) protein.

  KODAN ATSUSHI; KIMURA YASUHISA; KATO HIROAKI; UEDA KAZUMITSU

  未来材料, 10 Oct. 2006

  
• Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface

  Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  GENES TO CELLS, Sep. 2006, Peer-reviewed

  
• Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation (vol 61, pg 491, 2006)

  Kazufumi Yazaki; Nao Yamanaka; Tsugumi Masuno; Satoshi Konagai; Nobukazu Shitan; Shuji Kaneko; Kazumitsu Ueda; Fumihiko Sato

  PLANT MOLECULAR BIOLOGY, Aug. 2006, Peer-reviewed

  
• Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

  Aya Kobayashi; Yasukazu Takanezawa; Takashi Hirata; Yuji Shimizu; Keiko Misasa; Noriyuki Kioka; Hiroyuki Arai; Kazumitsu Ueda; Michinori Matsuo

  JOURNAL OF LIPID RESEARCH, Aug. 2006, Peer-reviewed

  
• Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

  Sachi Nagao; Koji Murao; Hitomi Imachi; Wen-Ming Cao; Xiao Yu; Junhua Li; Kensuke Matsumoto; Takamasa Nishiuchi; Rania A. M. Ahmed; Norman C. W. Wong; Kazumitsu Ueda; Toshihiko Ishida

  FEBS LETTERS, Aug. 2006, Peer-reviewed

  
• Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner

  Sumiko Abe-Dohmae; Koichi H. Kato; Yoshitaka Kumon; Wei Hu; Hideaki Ishigami; Noriyuki Iwamoto; Mitsuyo Okazaki; Chen-Ai Wu; Maki Tsujita; Kazumitsu Ueda; Shinji Yokoyama

  JOURNAL OF LIPID RESEARCH, Jul. 2006, Peer-reviewed

  
• Abl kinase interacts with and phosphorylates vinexin

  Masaru Mitsushima; Honami Takahashi; Tomoyuki Shishido; Kazumitsu Ueda; Noriyuki Kioka

  FEBS LETTERS, Jul. 2006, Peer-reviewed

  
• Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation

  Kazufumi Yazaki; Nao Yamanaka; Tsugumi Masuno; Satoshi Konagai; Shuji Kaneko; Kazumitsu Ueda; Fumihiko Sato

  PLANT MOLECULAR BIOLOGY, Jun. 2006, Peer-reviewed

  
• Purification and ATPase activity of human ABCA1

  K Takahashi; Y Kimura; N Kioka; M Matsuo; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed

  
• A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

  K Mutoh; J Mitsuhashi; Y Kimura; S Tsukahara; E Ishikawa; K Sai; S Ozawa; J Sawada; K Ueda; K Katayama; Y Sugimoto

  MOLECULAR CANCER THERAPEUTICS, Apr. 2006, Peer-reviewed

  
• Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin

  M Mitsushima; T Sezaki; R Akahane; K Ueda; S Suetsugu; T Takenawa; N Kioka

  GENES TO CELLS, Mar. 2006, Peer-reviewed

  
• ABCA7, a molecule with unknown function

  S Abe-Dohmae; K Ueda; S Yokoyama

  FEBS LETTERS, Feb. 2006, Peer-reviewed

  
• [ABC proteins move lipids].

  Ueda K; Takahashi K; Kobayashi A; Matsuo M

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., Apr. 2006, Peer-reviewed

  
• Detection of ABCA7-positive cells in salivary glands from patients with Sjogren's syndrome

  Y Toda; R Aoki; Y Ikeda; Y Azuma; N Kioka; M Matsuo; M Sakamoto; S Mori; M Fukumoto; K Ueda

  PATHOLOGY INTERNATIONAL, Oct. 2005, Peer-reviewed

  
• Role of interaction with vinculin in recruitment of vinexins to focal adhesions

  H Takahashi; M Mitsushima; N Okada; T Ito; S Aizawa; R Akahane; T Umemoto; K Ueda; N Kioka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2005, Peer-reviewed

  
• Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7

  M Hayashi; S Abe-Dohmae; M Okazaki; K Ueda; S Yokoyama

  JOURNAL OF LIPID RESEARCH, Aug. 2005, Peer-reviewed

  
• Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism

  N Ban; M Sasaki; H Sakai; K Ueda; N Inagaki

  BIOCHEMICAL JOURNAL, Jul. 2005, Peer-reviewed

  
• K-ATP channel interaction with adenine nucleotides

  M Matsuo; Y Kimura; K Ueda

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jun. 2005, Peer-reviewed

  
• Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner

  R Arakawa; N Tamehiro; T Nishimaki-Mogami; K Ueda; S Yokoyama

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jun. 2005, Peer-reviewed

  
• [Glucose intolerance induced by tacrolimus (FK506), cyclosporin A].

  Ueda K; Tanizawa Y

  Nihon rinsho. Japanese journal of clinical medicine, Feb. 2005, Peer-reviewed

  
• ABC proteins: Key molecules for lipid homeostasis

  Kei Takahashi; Yasuhisa Kimura; Koh Nagata; Akitsugu Yamamoto; Michinori Matsuo; Kazumitsu Ueda

  Medical Molecular Morphology, 2005, Peer-reviewed

  
• ABC proteins as molecular targets for drug discovery

  A. Kobayashi; Y. Kimura; M. Matsuo; K. Ueda

  Folia Pharmacologica Japonica, 2005, Peer-reviewed

  
• Human ABCA3, a product of a responsible gene fair abca3 for fatal surfactant deficiency in newborns, exhibit unique ATP hydrolysis activity and generates intracellular multilamellar vesicles

  K Nagata; A Yamamoto; N Ban; AR Tanaka; M Matsuo; N Kioka; N Inagaki; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2004, Peer-reviewed

  
• Effect of PCB-126 on intracellular accumulation and transepithelial transport of vinblastine in LLC-PK1 and its transformant cells expressing human P-glycoprotein

  S Sasawatari; M Toki; T Horie; Y Nakano; T Ikeda; K Ueda; H Fujise

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Sep. 2004, Peer-reviewed

  
• Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin

  M Mitsushima; A Suwa; T Amachi; K Ueda; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2004, Peer-reviewed

  
• 3,3 ',4,4 ',5-pentachlorobiphenyl inhibits drug efflux through P-glycoprotein in KB-3 cells expressing mutant human P-glycoprotein

  H Fujise; S Sasawatari; T Annoura; T Ikeda; K Ueda

  JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, Jul. 2004, Peer-reviewed

  
• ABC proteins involved in lipid homeostasis

  K Ueda

  SEIKAGAKU, Jun. 2004, Peer-reviewed

  
• alpha 1-syntrophin modulates turnover of ABCA1

  Y Munehira; T Ohnishi; S Kawamoto; A Furuya; K Shitara; M Imamura; T Yokota; S Takeda; T Amachi; M Matsuo; N Kioka; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2004, Peer-reviewed

  
• Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column

  Y Kimura; S Shibasaki; K Morisato; N Ishizuka; H Minakuchi; K Nakanishi; M Matsuo; T Amachi; M Ueda; K Ueda

  ANALYTICAL BIOCHEMISTRY, Mar. 2004, Peer-reviewed

  
• Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via liver X receptor-independent mechanism

  S Suzuki; T Nishimaki-Mogami; N Tamehiro; K Inoue; R Arakawa; S Abe-Dohmae; AR Tanaka; K Ueda; S Yokoyama

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Mar. 2004, Peer-reviewed

  
• ATP hydrolysis-dependent multidrug efflux transporter: MDRI/P-glycoprotein

  Y Kimura; M Matsuo; K Takahashi; T Saeki; N Kioka; T Amachi; K Ueda

  CURRENT DRUG METABOLISM, Feb. 2004, Peer-reviewed

  
• Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein

  S Abe-Dohmae; Y Ikeda; M Matsuo; M Hayashi; K Okuhira; K Ueda; S Yokoyama

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2004, Peer-reviewed

  
• Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release

  Y Ikeda; S Abe-Dohmae; Y Munehira; R Aoki; S Kawamoto; A Furuya; K Shitara; T Amachi; N Kioka; M Matsuo; S Yokoyama; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2003, Peer-reviewed

  
• Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact

  M Wakabayashi; T Ito; M Mitsushima; S Aizawa; K Ueda; T Amachi; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2003, Peer-reviewed

  
• Erratum: Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis (The Journal of Biological Chemistry (2003) 278 (8815-8819))

  Arowu R. Tanaka; Arowu R. Tanaka; Sumiko Abe-Dohmae; Tomohiro Ohnishi; Ryo Aoki; Gaku Morinaga; Kei Ichiro Okuhira; Yuika Ikeda; Fumi Kano; Michinori Matsuo; Noriyuki Kioka; Teruo Amachi; Masayuki Murata; Shinji Yokoyama; Kazumitsu Ueda

  Journal of Biological Chemistry, 18 Apr. 2003

  
• Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis

  AR Tanaka; S Abe-Dohmae; T Ohnishi; R Aoki; G Morinaga; K Okuhira; Y Ikeda; F Kano; M Matsuo; N Kioka; T Amachi; M Murata; S Yokoyama; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2003, Peer-reviewed

  
• Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A

  H Umehara; Y Nishii; M Morishima; Y Kakehi; N Kioka; T Amachi; J Koizumi; M Hagiwara; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2003, Peer-reviewed

  
• Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins

  K Terasaka; N Shitan; F Sato; F Maniwa; K Ueda; K Yazaki

  PLANT AND CELL PHYSIOLOGY, Feb. 2003, Peer-reviewed

  
• Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists

  Y Sugimoto; S Tsukahara; Y Imai; Y Sugimoto; K Ueda; T Tsuruo

  MOLECULAR CANCER THERAPEUTICS, Jan. 2003, Peer-reviewed

  
• Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica

  N Shitan; Bazin, I; K Dan; K Obata; K Kigawa; K Ueda; F Sato; C Forestier; K Yazaki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2003, Peer-reviewed

  
• Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome

  K Hashimoto; T Uchiumi; T Konno; T Ebihara; T Nakamura; M Wada; S Sakisaka; F Maniwa; T Amachi; K Ueda; M Kuwano

  HEPATOLOGY, Nov. 2002, Peer-reviewed

  
• ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)

  AR Tanaka; K Tanabe; M Morita; M Kurisu; Y Kasiwayama; M Matsuo; N Kioka; T Amachi; T Imanaka; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein

  K Sakai; N Shitan; F Sato; K Ueda; K Yazaki

  JOURNAL OF EXPERIMENTAL BOTANY, Sep. 2002, Peer-reviewed

  
• Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands

  T Ohama; K Hirano; ZY Zhang; R Aoki; K Tsujii; Y Nakagawa-Toyama; K Tsukamoto; C Ikegami; A Matsuyama; M Ishigami; N Sakai; H Hiraoka; K Ueda; S Yamashita; Y Matsuzawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2002, Peer-reviewed

  
• Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding

  M Matsuo; M Dabrowski; K Ueda; FM Ashcroft

  EMBO JOURNAL, Aug. 2002, Peer-reviewed

  
• Vinexin beta regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor

  A Suwa; M Mitsushima; T Ito; M Akamatsu; K Ueda; T Amachi; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2002, Peer-reviewed

  
• Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein

  H Fujise; T Annoura; S Sasawatari; T Ikeda; K Ueda

  CHEMOSPHERE, Mar. 2002, Peer-reviewed

  
• Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction

  N Kioka; K Ueda; T Amachi

  CELL STRUCTURE AND FUNCTION, Feb. 2002, Peer-reviewed

  
• [XYZ of ABC proteins?: where is the goal for the study of ABC protein structure?].

  Matsuo M; Ueda K

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Sep. 2002, Peer-reviewed

  
• Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal

  T Kawauchi; M Ikeya; S Takada; K Ueda; M Shirai; Y Takihara; N Kioka; T Amachi

  MECHANISMS OF DEVELOPMENT, Aug. 2001, Peer-reviewed

  
• Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function

  ZS Chen; S Aoki; M Komatsu; K Ueda; T Sumizawa; T Furukawa; H Okumura; XQ Ren; MG Belinsky; K Lee; GD Kruh; M Kobayashi; S Akiyama

  INTERNATIONAL JOURNAL OF CANCER, Jul. 2001, Peer-reviewed

  
• Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome

  AR Tanaka; Y Ikeda; S Abe-Dohmae; R Arakawa; K Sadanami; A Kidera; S Nakagawa; T Nagase; R Aoki; N Kioka; T Amachi; S Yokoyama; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2001, Peer-reviewed

  
• Molecular mechanism of multidrug transporter MDR 1: ABC in host-defense machinery.

  植田和光

  蛋白質 核酸 酵素, 01 Apr. 2001, Peer-reviewed

  
• A novel Coptis japonica multidrug-resistant protein preferentially expressed in the alkaloid-accumulating rhizome

  K Yazaki; N Shitan; H Takamatsu; K Ueda; F Sato

  JOURNAL OF EXPERIMENTAL BOTANY, Apr. 2001, Peer-reviewed

  
• Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy

  M Matsuo; S Trapp; Y Tanizawa; N Kioka; T Amachi; Y Oka; FM Ashcroft; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2000, Peer-reviewed

  
• Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2

  LX Zhao; CJ Zhou; A Tanaka; M Nakata; T Hirabayashi; T Amachi; S Shioda; K Ueda; N Inagaki

  BIOCHEMICAL JOURNAL, Sep. 2000, Peer-reviewed

  
• Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B

  M Matsuo; K Tanabe; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2000, Peer-reviewed

  
• Molecular mechanism of defence to toxic substance

  K Ueda; T Amachi

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, Jul. 2000, Peer-reviewed

  
• Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1

  K Nagata; M Nishitani; M Matsuo; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2000, Peer-reviewed

  
• Direct photoaffinity labeling of Kir6.2 by [gamma-P-32]ATP-[gamma]4-azidoanilide

  K Tanabe; SJ Tucker; FM Ashcroft; P Proks; N Kioka; T Amachi; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2000, Peer-reviewed

  
• CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line

  Y Nishii; M Morishima; Y Kakehi; K Umehara; N Kioka; Y Terano; T Amachi; K Ueda

  FEBS LETTERS, Jan. 2000, Peer-reviewed

  
• ABC transporters: Molecular mechanisms and roles in the host defense machinery

  UEDA Kazumitsu; AMACHI Teruo

  Bioscience & industry, 01 Jan. 2000, Peer-reviewed

  
• Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy - Nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1

  Y Tanizawa; K Matsuda; M Matsuo; Y Ohta; N Ochi; M Adachi; M Koga; S Mizuno; M Kajita; Y Tanaka; K Tachibana; H Inoue; S Furukawa; T Amachi; K Ueda; Y Oka

  DIABETES, Jan. 2000, Peer-reviewed

  
• Molecular mechanism of defence to toxic substance

  Kazumitsu Ueda; Teruo Amachi

  Nippon Nogeikagaku Kaishi, 2000, Peer-reviewed

  
• ABCトランスポーター:医薬開発のターゲット

  植田 和光

  バイオサイエンスとインダストリー,58/,23, 2000, Peer-reviewed

  
• How do P-glycoprotein and other ABC proteins recognize their substrates?

  K Ueda; Y Taguchi

  CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS, 2000, Peer-reviewed

  
• ATP binding properties of the nucleotide-binding folds of SUR1

  M Matsuo; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

  
• Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities

  M Akamatsu; S Aota; A Suwa; K Ueda; T Amachi; KM Yamada; SK Akiyama; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

  
• Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins

  K Ueda; M Matsuo; K Tanabe; K Morita; N Kioka; T Amachi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 1999, Peer-reviewed

  
• Antitumor activity of KF22678, a novel thioester derivative of leinamycin

  T Ashizawa; K Kawashima; Y Kanda; K Gomi; M Okabe; K Ueda; T Tamaoki

  ANTI-CANCER DRUGS, Oct. 1999, Peer-reviewed

  
• NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1

  M Matsuo; SJ Tucker; FM Ashcroft; T Amachi; K Ueda

  FEBS LETTERS, Sep. 1999, Peer-reviewed

  
• Removal of digoxin and doxorubicin by multidrug resistance protein-overexpressed cell culture in hollow fiber

  S Tsuruoka; K Sugimoto; K Ueda; M Suzuki; M Imai; A Fujimura

  KIDNEY INTERNATIONAL, Jul. 1999, Peer-reviewed

  
• ATP-dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P

  ZS Chen; T Furukawa; T Sumizawa; K Ono; K Ueda; K Seto; SI Akiyama

  MOLECULAR PHARMACOLOGY, May 1999, Peer-reviewed

  
• Recent progress in P-glycoprotein research

  K Ueda; A Yoshida; T Amachi

  ANTI-CANCER DRUG DESIGN, Apr. 1999, Peer-reviewed

  
• Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP

  K Tanabe; SJ Tucker; M Matsuo; P Proks; FM Ashcroft; S Seino; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1999, Peer-reviewed

  
• Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide

  K Ueda; J Komine; M Matsuo; S Seino; T Amachi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1999, Peer-reviewed

  
• 薬剤耐性の分子生物学的機序

  植田 和光

  炎症と免疫,7/,114-120, 1999, Peer-reviewed

  
• トランスポーター型ABCタンパク質P糖タンパク質

  植田 和光

  最新医学,54/,360-365, 1999, Peer-reviewed

  
• アプローチ:ABCタンパク質の多機能性と生体防御.

  植田 和光

  最新医学,54/,352-359, 1999, Peer-reviewed

  
• Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein

  N Kusunoki; K Takara; Y Tanigawara; A Yamauchi; K Ueda; F Komada; Y Ku; Y Kuroda; Y Saitoh; K Okumura

  JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1998, Peer-reviewed

  
• Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein

  Y Takeda; K Yamada; Y Taguchi; K Kino; M Matsuo; SJ Tucker; T Komano; T Amachi; K Ueda

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Aug. 1998, Peer-reviewed

  
• Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets

  K Ueda; Y Tanizawa; H Ishihara; N Kizuki; Y Ohta; A Matsutani; Y Oka

  DIABETOLOGIA, Jun. 1998, Peer-reviewed

  
• Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM

  Y Ohta; Y Tanizawa; H Inoue; T Hosaka; K Ueda; A Matsutani; VP Repunte; M Yamada; Y Kurachi; J Bryan; L Aguilar-Bryan; MA Permutt; Y Oka

  DIABETES, Mar. 1998, Peer-reviewed

  
• MgADP antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1

  K Ueda; N Inagaki; S Seino

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1997, Peer-reviewed

  
• Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

  Y Taguchi; M Morishima; T Komano; K Ueda

  FEBS LETTERS, Aug. 1997, Peer-reviewed

  
• MDR 1/P-glycoprotein: An efflux pump of lipophilic xenobiotics

  K Ueda

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, Aug. 1997, Peer-reviewed

  
• Alteration of substrate specificity by mutations at the His(61) position in predicted transmembrane domain 1 of human MDR1/P-glycoprotein

  Y Taguchi; K Kino; M Morishima; T Komano; SE Kane; K Ueda

  BIOCHEMISTRY, Jul. 1997, Peer-reviewed

  
• How does P-glycoprotein recognize its substrates?

  K Ueda; Y Taguchi; M Morishima

  SEMINARS IN CANCER BIOLOGY, Jun. 1997, Peer-reviewed

  
• Protein kinase C-independent correlation between P-glycoprotein expression and volume sensitivity of Cl- channel

  A Miwa; K Ueda; Y Okada

  JOURNAL OF MEMBRANE BIOLOGY, May 1997, Peer-reviewed

  
• Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene

  K Tanaka; M Hirai; Y Tanigawara; K Ueda; M Takano; R Hori; K Inui

  BIOCHEMICAL PHARMACOLOGY, Mar. 1997, Peer-reviewed

  
• Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP)

  Y Taguchi; A Yoshida; Y Takada; T Komano; K Ueda

  FEBS LETTERS, Jan. 1997, Peer-reviewed

  
• [Molecular mechanisms for drug transport by MDR1/P-glycoprotein]

  Ueda K

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jun. 1997, Peer-reviewed

  
• 生体異物排出ポンプP-糖蛋白質とMRPの構造と活性-分子標的としての重要性-

  植田 和光

  癌と化学療法,/,24, 1997, Peer-reviewed

  
• 生体異物排出ポンプMDR1/P-糖タンパク質の分子機構.

  植田 和光

  日本農芸化学会誌,71/8,785, 1997, Peer-reviewed

  
• 抗癌剤に対する膜輸送機構の変化を介した耐性獲得.

  植田 和光

  日本臨床,55/5,1024, 1997, Peer-reviewed

  
• MDR1/P-糖タンパク質の薬剤輸送の分子機構.

  植田 和光

  蛋白質核酸酵素,42/8,1263, 1997, Peer-reviewed

  
• Volume-sensitive Cl- channel in human epithelial cells: Regulation by ATP and relation to P-glycoprotein

  Yasunobu Okada; Shigetoshi Oiki; Makoto Tominaga; Machiko Kubo; Akiko Miwa; Tomoko Tominaga; Takashi Tsumura; Kazumitsu Ueda

  Japanese Journal of Physiology, 1997, Peer-reviewed

  
• Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins

  K Kino; Y Taguchi; K Yamada; T Komano; K Ueda

  FEBS LETTERS, Dec. 1996, Peer-reviewed

  
• Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein

  K Tanaka; M Hirai; Y Tanigawara; M Yasuhara; R Hori; K Ueda; K Inui

  PHARMACEUTICAL RESEARCH, Jul. 1996, Peer-reviewed

  
• CEPHARANTHIN, A MULTIDRUG-RESISTANT MODIFIER, IS A SUBSTRATE FOR P-GLYCOPROTEIN

  M HIRAI; K TANAKA; T SHIMIZU; Y TANIGAWARA; M YASUHARA; R HORI; Y KAKEHI; O YOSHIDA; K UEDA; T KOMANO; KI INUI

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Oct. 1995, Peer-reviewed

  
• Family and super family of gene and proteins. Membrane transporter. ATP binding cassette transporter super family.

  植田和光

  生体の科学, Sep. 1995, Peer-reviewed

  
• P glyco proteins and anticancer drug resistance.

  植田和光

  Bio Clin, Dec. 1994, Peer-reviewed

  
• HUMAN P-GLYCOPROTEIN AS A MULTIDRUG TRANSPORTER ANALYZED BY USING TRANSEPITHELIAL TRANSPORT-SYSTEM

  K UEDA; T SAEKI; M HIRAI; Y TANIGAWARA; K TANAKA; M OKAMURA; M YASUHARA; R HORI; K INUI; T KOMANO

  JAPANESE JOURNAL OF PHYSIOLOGY, 1994, Peer-reviewed

  
• TRANSACTIVATION OF THE HUMAN MULTIDRUG-RESISTANCE (MDR1) GENE PROMOTER BY P53 MUTANTS

  KT NGUYEN; BR LIU; K UEDA; MM GOTTESMAN; PASTAN, I; KV CHIN

  ONCOLOGY RESEARCH, 1994, Peer-reviewed

  
• Structure and function of multidrug resistance(MDR) gene.

  植田和光; 駒野徹

  医学のあゆみ, 16 Oct. 1993, Peer-reviewed

  
• FUNCTIONAL EXPRESSION OF HUMAN P-GLYCOPROTEIN IN SCHIZOSACCHAROMYCES-POMBE

  K UEDA; AM SHIMABUKU; H KONISHI; Y FUJII; S TAKEBE; K NISHI; M YOSHIDA; T BEPPU; T KOMANO

  FEBS LETTERS, Sep. 1993, Peer-reviewed

  
• DIGOXIN-CYCLOSPORINE A-INTERACTION - MODULATION OF THE MULTIDRUG TRANSPORTER P-GLYCOPROTEIN IN THE KIDNEY

  N OKAMURA; M HIRAI; Y TANIGAWARA; K TANAKA; M YASUHARA; K UEDA; T KOMANO; R HORI

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Sep. 1993, Peer-reviewed

  
• P-GLYCOPROTEIN-MEDIATED TRANSCELLULAR TRANSPORT OF MDR-REVERSING AGENTS

  T SAEKI; K UEDA; Y TANIGAWARA; R HORI; T KOMANO

  FEBS LETTERS, Jun. 1993, Peer-reviewed

  
• HUMAN P-GLYCOPROTEIN TRANSPORTS CYCLOSPORINE-A AND FK506

  T SAEKI; K UEDA; Y TANIGAWARA; R HORI; T KOMANO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1993, Peer-reviewed

  
• Pー糖蛋白質の遺伝子と機能

  植田 和光

  ,/10,8-14, 1993, Peer-reviewed

  
• P-糖蛋白質

  植田 和光

  廣川タンパク質化学第2巻受容体タンパク質II,2,453-459, 1993, Peer-reviewed

  
• [要修正] MDRI遺伝子の構造と機能

  植田 和光

  ,30,688-695, 1993, Peer-reviewed

  
• HUMAN P-GLYCOPROTEIN TRANSPORTS CORTISOL, ALDOSTERONE, AND DEXAMETHASONE, BUT NOT PROGESTERONE

  K UEDA; N OKAMURA; M HIRAI; Y TANIGAWARA; T SAEKI; N KIOKA; T KOMANO; R HORI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1992, Peer-reviewed

  
• TRANSPORT OF DIGOXIN BY HUMAN P-GLYCOPROTEIN EXPRESSED IN A PORCINE KIDNEY EPITHELIAL-CELL LINE (LLC-PK1)

  Y TANIGAWARA; N OKAMURA; M HIRAI; M YASUHARA; K UEDA; N KIOKA; T KOMANO; R HORI

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 1992, Peer-reviewed

  
• PREPARATION AND CHARACTERIZATION OF A MURINE MONOCLONAL-ANTIBODY (MDR3M) REACTIVE WITH MDR3 GENE-PRODUCT

  SUGAWARA, I; A HIRATA; K UEDA; S ITOYAMA

  JAPANESE JOURNAL OF CANCER RESEARCH, Aug. 1992, Peer-reviewed

  
• Specific drug binding by purified lipid-reconstituted P-glycoprotein: Dependence on the lipid composition

  Tohru Saeki; Alfredo M. Shimabuku; Kazumitsu Ueda; Tohru Komano

  BBA - Biomembranes, 11 Jun. 1992, Peer-reviewed

  
• SPECIFIC DRUG-BINDING BY PURIFIED LIPID-RECONSTITUTED P-GLYCOPROTEIN - DEPENDENCE ON THE LIPID-COMPOSITION

  T SAEKI; AM SHIMABUKU; K UEDA; T KOMANO

  BIOCHIMICA ET BIOPHYSICA ACTA, Jun. 1992, Peer-reviewed

  
• QUERCETIN, A BIOFLAVONOID, INHIBITS THE INCREASE OF HUMAN MULTIDRUG RESISTANCE GENE (MDR1) EXPRESSION CAUSED BY ARSENITE

  N KIOKA; N HOSOKAWA; T KOMANO; K HIRAYOSHI; K NAGATA; K UEDA

  FEBS LETTERS, Apr. 1992, Peer-reviewed

  
• HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)

  N KIOKA; Y YAMANO; T KOMANO; K UEDA

  FEBS LETTERS, Apr. 1992, Peer-reviewed

  
• P-GLYCOPROTEIN - ATP HYDROLYSIS BY THE N-TERMINAL NUCLEOTIDE-BINDING DOMAIN

  AM SHIMABUKU; T NISHIMOTO; K UEDA; T KOMANO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1992, Peer-reviewed

  
• ALTERNATIVE SECONDARY STRUCTURES IN THE PHAGE-G4 ORIGIN OF THE COMPLEMENTARY-DNA STRAND SYNTHESIS - EFFECTS OF NACL CONCENTRATION ON THE BLEOMYCIN DNA INTERACTION

  K UEDA; H HIASA; S TAKEBE; H SAKAI; T KOMANO

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Mar. 1992, Peer-reviewed

  
• PRIMER-DEPENDENT AMPLIFICATION OF MDR1 MESSENGER-RNA BY POLYMERASE CHAIN-REACTION

  SUGAWARA, I; M WATANABE; A MASUNAGA; S ITOYAMA; K UEDA

  JAPANESE JOURNAL OF CANCER RESEARCH, Feb. 1992, Peer-reviewed

  
• MODULATION OF ACTIVITY OF THE PROMOTER OF THE HUMAN MDR1 GENE BY RAS AND P53

  KV CHIN; K UEDA; PASTAN, I; MM GOTTESMAN

  SCIENCE, Jan. 1992, Peer-reviewed

  
• Biochemistry of Human P-Glycoproteins, the Multidrug Transporter

  Kazumitsu Ueda

  Nippon Nogeikagaku Kaishi, 1992, Peer-reviewed

  
• 多剤耐性遺伝子MDR1

  植田 和光

  化学と生物,/30,410-411, 1992, Peer-reviewed

  
• EXPRESSION OF HUMAN P-GLYCOPROTEIN IN YEAST-CELLS - EFFECTS OF MEMBRANE COMPONENT STEROLS ON THE ACTIVITY OF P-GLYCOPROTEIN

  T SAEKI; AM SHIMABUKU; Y AZUMA; Y SHIBANO; T KOMANO; K UEDA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed

  
• PRODUCTION OF A SITE SPECIFICALLY CLEAVABLE P-GLYCOPROTEIN-BETA-GALACTOSIDASE FUSION PROTEIN

  AM SHIMABUKU; T SAEKI; K UEDA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Apr. 1991, Peer-reviewed

  
• DIFFERENT DRUG SENSITIVITY IN 2 NEUROBLASTOMA CELL-LINES ESTABLISHED FROM THE SAME PATIENT BEFORE AND AFTER CHEMOTHERAPY

  H KURODA; T SUGIMOTO; K UEDA; S TSUCHIDA; Y HORII; J INAZAWA; K SATO; T SAWADA

  INTERNATIONAL JOURNAL OF CANCER, Mar. 1991, Peer-reviewed

  
• 抗癌剤を細胞外に排出するPー糖蛋白質の本来の基質は何か

  植田 和光

  化学,/46,428-429, 1991, Peer-reviewed

  
• INSITU LOCALIZATION OF THE HUMAN MULTIDRUG-RESISTANCE GENE MESSENGER-RNA USING THYMINE-THYMINE DIMERIZED SINGLE-STRANDED CDNA

  SUGAWARA, I; T KOJI; K UEDA; PASTAN, I; MM GOTTESMAN; PK NAKANE; S MORI

  JAPANESE JOURNAL OF CANCER RESEARCH, Sep. 1990, Peer-reviewed

  
• EXPRESSION OF A HUMAN COMPLEMENTARY-DNA FOR THE MULTIDRUG RESISTANCE GENE IN MURINE HEMATOPOIETIC PRECURSOR CELLS WITH THE USE OF RETROVIRAL GENE-TRANSFER

  MCLACHLIN, JR; MA EGLITIS; K UEDA; PW KANTOFF; IH PASTAN; WF ANDERSON; MM GOTTESMAN

  JOURNAL OF THE NATIONAL CANCER INSTITUTE, Aug. 1990, Peer-reviewed

  
• USE OF RECOMBINANT P-GLYCOPROTEIN FRAGMENTS TO PRODUCE ANTIBODIES TO THE MULTIDRUG TRANSPORTER

  S TANAKA; SJ CURRIER; EP BRUGGEMANN; K UEDA; UA GERMANN; PASTAN, I; MM GOTTESMAN

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1990, Peer-reviewed

  
• THE EFFECTS OF METAL-IONS ON THE DNA DAMAGE INDUCED BY HYDROGEN-PEROXIDE

  S KOBAYASHI; K UEDA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jan. 1990, Peer-reviewed

  
• EXPRESSION OF THE MULTIDRUG RESISTANCE, MDR1, GENE IN NEUROBLASTOMAS

  LJ GOLDSTEIN; AT FOJO; K UEDA; W CRIST; A GREEN; G BRODEUR; PASTAN, I; MM GOTTESMAN

  JOURNAL OF CLINICAL ONCOLOGY, Jan. 1990, Peer-reviewed

  
• ヒト多剤耐性遺伝子を担うMDR1遺伝子の構造と機能

  植田 和光

  ファルマシア,/26,809-813, 1990, Peer-reviewed

  
• 多剤耐性の分子機構

  植田 和光

  腫瘍と感染,/3,443-450, 1990, Peer-reviewed

  
• MDR1とPー糖蛋白質

  植田 和光

  ,/6,301-306, 1990, Peer-reviewed

  
• GENOMIC ORGANIZATION OF THE HUMAN MULTIDRUG RESISTANCE (MDR1) GENE AND ORIGIN OF P-GLYCOPROTEINS

  CJ CHEN; D CLARK; K UEDA; PASTAN, I; MM GOTTESMAN; IB RONINSON

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1990, Peer-reviewed

  
• DETECTION OF MULTIDRUG RESISTANCE (MDR1) GENE RNA EXPRESSION IN HUMAN-TUMORS BY A SENSITIVE RIBONUCLEASE PROTECTION ASSAY

  K UEDA; Y YAMANO; N KIOKA; Y KAKEHI; O YOSHIDA; MM GOTTESMAN; PASTAN, I; T KOMANO

  JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1989, Peer-reviewed

  
• DELETION AND INSERTION MUTANTS OF THE MULTIDRUG TRANSPORTER

  SJ CURRIER; K UEDA; MC WILLINGHAM; PASTAN, I; MM GOTTESMAN

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1989, Peer-reviewed

  
• P-GLYCOPROTEIN GENE (MDR1) CDNA FROM HUMAN ADRENAL - NORMAL P-GLYCOPROTEIN CARRIES GLY185 WITH AN ALTERED PATTERN OF MULTIDRUG RESISTANCE

  N KIOKA; J TSUBOTA; Y KAKEHI; T KOMANO; MM GOTTESMAN; PASTAN, I; K UEDA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1989, Peer-reviewed

  
• USE OF A CLONED MULTIDRUG RESISTANCE GENE FOR COAMPLIFICATION AND OVERPRODUCTION OF MAJOR EXCRETED PROTEIN, A TRANSFORMATION-REGULATED SECRETED ACID PROTEASE

  SE KANE; BR TROEN; S GAL; K UEDA; PASTAN, I; MM GOTTESMAN

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 1988, Peer-reviewed

  
• 癌の多剤耐性はＭＤＲ１遺伝子が担っているのか？

  植田和光

  蛋白質 核酸 酵素, Jul. 1988, Peer-reviewed

  
• A RETROVIRUS CARRYING AN MDR1 CDNA CONFERS MULTIDRUG RESISTANCE AND POLARIZED EXPRESSION OF P-GLYCOPROTEIN IN MDCK CELLS

  PASTAN, I; MM GOTTESMAN; K UEDA; E LOVELACE; AV RUTHERFORD; MC WILLINGHAM

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 1988, Peer-reviewed

  
• DNA damage induced by ascorbate in the presence of Cu2+

  So Kobayashi; Kazumitsu Ueda; Junji Morita; Hiroshi Sakai; Tohru Komano

  BBA - Gene Structure and Expression, 25 Jan. 1988, Peer-reviewed

  
• DNA DAMAGE INDUCED BY ASCORBATE IN THE PRESENCE OF CU-2+

  S KOBAYASHI; K UEDA; J MORITA; H SAKAI; T KOMANO

  BIOCHIMICA ET BIOPHYSICA ACTA, Jan. 1988, Peer-reviewed

  
• The multidrug-resistance gene MDR1

  K. Ueda; T. Komano

  Japanese Journal of Cancer and Chemotherapy, 1988, Peer-reviewed

  
• 多剤耐性遺伝子MDR1とその発見機構

  植田 和光

  細胞工学,/9,96-104, 1988, Peer-reviewed

  
• [要修正] 多剤耐性遺伝子MDR1.

  植田 和光

  癌と化学療法,/15,2858-2862, 1988, Peer-reviewed

  
• ISOLATION AND SEQUENCE OF THE PROMOTER REGION OF THE HUMAN MULTIDRUG-RESISTANCE (P-GLYCOPROTEIN) GENE

  K UEDA; PASTAN, I; MM GOTTESMAN

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1987, Peer-reviewed

  
• EXPRESSION OF A FULL-LENGTH CDNA FOR THE HUMAN MDR1 GENE CONFERS RESISTANCE TO COLCHICINE, DOXORUBICIN, AND VINBLASTINE

  K UEDA; C CARDARELLI; MM GOTTESMAN; PASTAN, I

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 1987, Peer-reviewed

  
• The human multidrug resistance(mdrl)gene.

  植田 和光

  The Journal of Biological Chemistry,262/2, 1987, Peer-reviewed

  
• MOLECULAR-BIOLOGY OF DRUG-RESISTANCE

  A FOJO; M CORNWELL; C CARDARELLI; DP CLARK; N RICHERT; DW SHEN; K UEDA; M WILLINGHAM; MM GOTTESMAN; PASTAN, I

  BREAST CANCER RESEARCH AND TREATMENT, 1987, Peer-reviewed

  
• THE HUMAN MULTIDRUG RESISTANCE (MDR1) GENE - CDNA CLONING AND TRANSCRIPTION INITIATION

  K UEDA; DP CLARK; C CHEN; IB RONINSON; MM GOTTESMAN; PASTAN, I

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1987, Peer-reviewed

  
• EXPRESSION OF A MULTIDRUG-RESISTANCE GENE IN HUMAN-TUMORS AND TISSUES

  AT FOJO; K UEDA; DJ SLAMON; DG POPLACK; MM GOTTESMAN; PASTAN, I

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1987, Peer-reviewed

  
• THE MDRL GENE, RESPONSIBLE FOR MULTIDRUG-RESISTANCE, CODES FOR P-GLYCOPROTEIN

  K UEDA; MM CORNWELL; MM GOTTESMAN; PASTAN, I; IB RONINSON; LING, V; RIORDAN, JR

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1986, Peer-reviewed

  
• INTERNAL DUPLICATION AND HOMOLOGY WITH BACTERIAL TRANSPORT PROTEINS IN THE MDR1 (P-GLYCOPROTEIN) GENE FROM MULTIDRUG-RESISTANT HUMAN-CELLS

  CJ CHEN; JE CHIN; K UEDA; DP CLARK; PASTAN, I; MM GOTTESMAN; IB RONINSON

  CELL, Nov. 1986, Peer-reviewed

  
• INTERNAL DUPLICATION AND HOMOLOGY WITH BACTERIAL TRANSPORT PROTEINS IN THE MDR1 (P-GLYCOPROTEIN) GENE FROM MULTIDRUG-RESISTANT HUMAN-CELLS

  CJ CHEN; JE CHIN; K UEDA; DP CLARK; PASTAN, I; MM GOTTESMAN; IB RONINSON

  CELL, Nov. 1986, Peer-reviewed

  
• SEQUENCE-SPECIFIC MODIFICATION OF DNA BY 6-HYDROXYBENZO[A]PYRENE

  J MORITA; K UEDA; S KOBAYASHI; T KOMANO

  BIOCHIMICA ET BIOPHYSICA ACTA, Oct. 1986, Peer-reviewed

  
• SEQUENCE-SPECIFIC ALKALI-LABILE LESIONS IN DNA CAUSED BY D-ISOGLUCOSAMINE

  S NANJOU; S FUJII; J MORITA; K UEDA; T KOMANO

  BIOCHIMICA ET BIOPHYSICA ACTA, Feb. 1986, Peer-reviewed

  
• Site-specific DNA damage caused by lipid peroxidation products

  Kazumitsu Ueda; So Kobayashi; Junji Morita; Tohru Komano

  BBA - Gene Structure and Expression, 19 Apr. 1985, Peer-reviewed

  
• CLEAVAGE OF STEM-AND-LOOP STRUCTURE DNA BY BLEOMYCIN - REACTION ON THE BACTERIOPHAGE-G4 ORIGIN OF COMPLEMENTARY STRAND SYNTHESIS

  K UEDA; S KOBAYASHI; H SAKAI; T KOMANO

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed

  
• SITE-SPECIFIC DNA DAMAGE CAUSED BY LIPID-PEROXIDATION PRODUCTS

  K UEDA; S KOBAYASHI; J MORITA; T KOMANO

  BIOCHIMICA ET BIOPHYSICA ACTA, 1985, Peer-reviewed

  
• INDUCTION OF SINGLE-STRAND SCISSION IN PHI-X174 RFI DNA BY D-ISOGLUCOSAMINE

  S NANJOU; S FUJII; K TANAKA; K UEDA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed

  
• SEQUENCE SPECIFIC DAMAGE OF DNA INDUCED BY REDUCING SUGARS

  J MORITA; K UEDA; S NANJO; T KOMANO

  NUCLEIC ACIDS RESEARCH, 1985, Peer-reviewed

  
• INDUCTION OF STRAND BREAKAGE IN PHI-X174 RFI DNA BY AMINOSUGAR DERIVATIVES

  S NANJOU; S FUJII; K TANAKA; K UEDA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, Peer-reviewed

  
• SEQUENCE-SPECIFIC DNA DAMAGE INDUCED BY REDUCED MITOMYCIN-C AND 7-N-PARA-HYDROXYPHENYL)MITOMYCIN-C

  K UEDA; T KOMANO

  NUCLEIC ACIDS RESEARCH, 1984, Peer-reviewed

  
• SEQUENCE SPECIFICITY OF HEAT-LABILE SITES IN DNA INDUCED BY MITOMYCIN-C

  K UEDA; J MORITA; T KOMANO

  BIOCHEMISTRY, 1984, Peer-reviewed

  
• A NEW PROCEDURE FOR DETERMINING THYMINE RESIDUES IN DNA SEQUENCING - PHOTOINDUCED CLEAVAGE OF DNA FRAGMENTS IN THE PRESENCE OF SPERMINE

  SAITO, I; H SUGIYAMA; T MATSUURA; K UEDA; T KOMANO

  NUCLEIC ACIDS RESEARCH, 1984, Peer-reviewed

  
• DNA STRAND BREAKAGE INVITRO BY AUTOXIDIZED UNSATURATED FATTY-ACIDS

  J MORITA; K UEDA; K NAKAI; Y BABA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1983, Peer-reviewed

  
• PHAGE INACTIVATION AND DNA STRAND SCISSION ACTIVITIES OF "7-N-(PARA-HYDROXYPHENYL)MITOMYCIN-C

  K UEDA; J MORITA; T KOMANO

  JOURNAL OF ANTIBIOTICS, 1982, Peer-reviewed

  
• ACTIONS OF MITOMYCIN-C REDUCED WITH SODIUM-BOROHYDRIDE ON BACTERIOPHAGE-PHI-X174 AND ITS SINGLE-STRANDED AND DOUBLE-STRANDED DNAS

  K UEDA; J MORITA; T KOMANO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1982, Peer-reviewed

  
• INDUCTION OF SINGLE-STRAND SCISSION IN BACTERIOPHAGE -PHI-X174 REPLICATIVE FORM-I DNA BY MITOMYCIN-C

  K UEDA; J MORITA; T KOMANO

  JOURNAL OF ANTIBIOTICS, 1981, Peer-reviewed

  
• INACTIVATION OF BACTERIOPHAGE PHI-X174 BY MITOMYCIN-C IN THE PRESENCE OF SODIUM HYDROSULFITE AND CUPRIC IONS

  K UEDA; J MORITA; K YAMASHITA; T KOMANO

  CHEMICO-BIOLOGICAL INTERACTIONS, 1980, Peer-reviewed

  
• ATP binding/hydrolysis by and phosphorylation of peroxisomal ABC proteins PMP70 (ABCD3) and ALDP (ABCD1). J. Biol. Chem. 277, 40142-40147

  植田 和光

  J. Biol. Chem. r,277, 40142-40147, Peer-reviewed

  

Misc.

• Serum amyloid a generates HDL in an ABCA1-or ABCA7-dependent manner

  S. Abe-Dohmae; Y. Kumon; W. Hu; H. Ishigami; N. Iwamoto; M. Okazaki; K. Ueda; S. Yokoyama

  ATHEROSCLEROSIS SUPPLEMENTS, Jun. 2006

  
• ABCタンパク質による脂質恒常性維持と生活習慣病

  植田 和光

  バイオサイエンスとインダストリー, Oct. 2005

  
• 創薬ターゲットとしてのABC蛋白質 (特集 ABCトランスポーターの機能と創薬)

  植田 和光

  細胞, May 2004

  
• 体内のコレステロールをコントロールする : 脂質トランスポートに関与するABC蛋白質

  植田 和光

  化学と生物, 25 Jan. 2004

  
• ABCタンパク質の構造と機能一生体防御のABC

  植田 和光

  動脈硬化 = The journal of Japan Atherosclerosis Society, 15 May 2001

  
• ATP駆動型トランスポーター (特集 トランスポーターの構造と機能協関)

  植田 和光; 天知 輝夫

  生体の科学, Aug. 1999

  
• Novel SR protein CROP : Interaction with SF2 and subnuclear localization

  UMEHARA Hiroshi; MORISHIMA Masaki; NISHII Yoichi; KAKEHI Yoshiyuki; HAGIWARA Masatoshi; UEDA Kazumitsu; AMACHI Teruo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Identification and functional analysis of variant SUR1 in Japanese with non-insulin-dependent diabetes mellitus

  Y Tanizawa; Y Ota; H Inoue; VP Repunte; M Yamada; K Ueda; J Nomiyama; Y Kurachi; MA Permutt; J Bryan; L AguilarBryan; Y Oka

  DIABETOLOGIA, Jun. 1997

  
• ディファレンシャル・ディスプレイ法によるシスプラチン耐性細胞で発現上昇している遺伝子の単離

  森嶋 正樹; 西井 洋一; 吉田 あや; 田口 善智; 駒野 徹; 筧 善行; 吉田 修; 植田 和光

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• ヒトP-糖蛋白質の2つのATP結合領域のATP加水分解および薬剤輸送への関与

  山田 浩司; 木野 孝一; 田口 善智; 駒野 徹; 植田 和光

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• 1996 Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry

  HAYAKAWA Yoichi; NAKANO Hideo; NAKAJIMA Tasuku; UEDA Kazumitsu; IRIE Kazuhiro; MASAKI Haruhiko

  Bioscience & industry, 01 Jun. 1996

  
• ニッケルカラムおよびS-Tag精製キットによるヒトP-糖蛋白質の精製 : 動物

  山田 浩司; 田口 善智; 植田 和光; 駒野 徹

  日本農藝化學會誌, 05 Mar. 1996

  
• 抗癌剤耐性に関わる膜輸送体の分子機構 : 生体膜のダイナミズム : 分子基盤と応用への新展開 : 第1部 : 膜輸送体の実像に迫る : シンポジウム(S-7)

  植田 和光; 田口 善智; 西井 洋一; 山田 浩司; 吉田 あや; 高田 裕子; 森嶋 正樹; 駒野 徹

  日本農藝化學會誌, 05 Mar. 1996

  
• 過酸化脂質産物に対するP-糖蛋白質発現細胞の高感受性 : 動物

  福田 綾; 大澤 俊彦; 植田 和光; 内田 浩二

  日本農藝化學會誌, 05 Mar. 1996

  
• ヒトMDR1及びMDR2/P-糖蛋白質は、いずれもペプチド性抗真菌剤オーレオバシジンAを基質とする : 動物

  木野 孝一; 山田 浩司; 田口 善智; 植田 和光; 駒野 徹

  日本農藝化學會誌, 05 Jul. 1995

  
• 遺伝子改変による多剤耐性を担うヒトMDR蛋白(P糖蛋白質)の機能部位の解析(動物-遺伝子-)

  植田 和光; Gottesman M.M.; Pastan I.; 山野 好章; 駒野 徹

  日本農藝化學會誌, 15 Mar. 1988

  
• HPLCによる薬物トランスポーターMDR1の新規ATP加水分解活性測定法

  木村泰久; 芝崎誠司; 森里恵; 松尾道憲; 木岡紀幸; 天知輝夫; 植田充美; 植田和光

  日本分子生物学会年会プログラム・講演要旨集, 2003

  
• 接着斑細胞膜脂質の単離と解析

  箕浦広大; 市川尚文; 大町朋弘; 真鍋祐樹; 菅原達也; 植田和光; 植田和光; 木岡紀幸

  脂質生化学研究, 2017

  
• 細胞-ECM間接着領域における細胞膜脂質組成の解析

  箕浦広大; 市川尚文; 大町朋弘; 植田和光; 植田和光; 木岡紀幸

  日本生化学会大会(Web), 2017

  
• 細胞収縮力発生におけるビネキシンファミリータンパク質の役割

  市川尚文; 松井翼; 松井翼; 荒木智彦; 喜多真弘; 植田和光; 植田和光; 出口真次; 出口真次; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ビネキシンファミリータンパク質の接着斑を介したメカノセンシング機能の比較解析

  市川尚文; 喜多真弘; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本細胞生物学会大会要旨集, 2015

  
• ビネキシン-ビンキュリン相互作用の生化学的解析

  市川尚文; 山下寛; 松山大輔; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集, 2011

  
• メカノセンサーとしてのビネキシン-ビンキュリン相互作用

  山下寛; 松山大輔; 市川尚文; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集, 2011

  
• ビネキシンとビンキュリンの結合は接着斑のビンキュリンを安定化させる

  松山大輔; 山下寛; 市川尚文; 植田和光; 植田和光; 木岡紀幸

  生化学, 2010

  
• ABC蛋白質のXYZ?--ABC蛋白質構造研究のゴールは見えたか?

  松尾 道憲; 植田 和光

  蛋白質核酸酵素, Sep. 2002

  
• 序「リポネットワーク」

  植田 和光; 稲垣 暢也; 酒井 寿郎

  生化学, 25 Jun. 2004

  
• Mechanism of substance recognition by P-glycoprotein : Relationship between structures of various pesticides and ATPase activity

  KANAOKA Satoshi; KIMURA Yasuhisa; NAKAGAWA Yoshiaki; UEDA Kazumitsu; AKAMATSU Miki

  日本農薬学会大会講演要旨集, 11 Mar. 2008

  
• Mechanism of substrate recognition by ABC proteins involved in lipid homeostasis

  木村 泰久; 松尾 道憲; 植田 和光

  最新医学, Nov. 2007

  
• Functional analysis of anticancer drug transporter MRP by nucleotide trapping method

  NISHITANI Masahito; UEDA Kazumitsu; AMACHI Teruo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Interaction of inwardly rectifying pottasium channel, Kir6.2 and ATP

  TANABE Kouichi; KOMINE Jun; MATSUO Michinori; TUCKER S. J.; ASHCROFT F. M.; SEINO Susumu; UEDA Kazumitsu; AMACHI Teruo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Inhibition of ATP binding to sulfonylurea receptor SURl by NEM

  MATSUO Michinori; TUCKER Stephen J.; ASHCROFT Frances M.; SEINO Susumu; UEDA Kazumitsu; AMACHI Teruo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Glibenclamide blocks the cooperative nucleotide binding to sulfonylurea receptor SURl

  KOMINE Jun; MATSUO Michinori; SEINO Susumu; UEDA Kazumitsu; AMACHI Teruo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• P-糖蛋白質の第1膜貫通領域のアミノ酸変異体の機能解析

  田口 善智; 森嶋 正樹; 駒野 徹; 植田 和光

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• ヒトMDR1/P-糖蛋白質の第一膜貫通領域が薬剤の認識・輸送に関与する可能性の検討 : 動物

  田口 善智; 森嶋 正樹; 植田 和光; 駒野 徹

  日本農藝化學會誌, 05 Mar. 1996

  
• ABCA1KOマウスにおけるABCA7発現分布とコレステロール負荷による変化

  岩本 紀之; 堂前 純子; 胡 巍; 林 弥智; 植田 和光; 横山 信治

  脂質生化学研究, 02 Jun. 2005

  
• Serum amyloid A 含有HDLの産生機序と特性

  堂前 純子; 胡 巍; 石神 秀昭; 岩本 紀之; 公文 義雄; 岡崎 三代; 呉 成愛; 辻田 麻紀; 植田 和光; 横山 信治

  脂質生化学研究, 02 Jun. 2005

  
• ABCA7によるアポリポタンパク質依存性細胞コレステロール放出反応

  堂前 純子; 林 弥智; 堀田 典子; 植田 和光; 横山 信治

  脂質生化学研究, 18 Jun. 2004

  
• HDL新生反応とABCタンパク質

  堂前 純子; 植田 和光; 荒川 礼二郎; 和田 洋一郎; 油谷 浩幸; 横山 信治

  動脈硬化 = The journal of Japan Atherosclerosis Society, 15 May 2001

  
• Change in the Drug Excretivity of Human Mutant P-Glycoprotein Expressing Cell, KB3

  ANNOURA Takeshi; SASAWATARI Shigemi; MATSUTANI Haruka; IKEDA Teruo; UEDA Kazumitsu; FUJISE Hiroshi

  Veterinary biochemistry, 30 Apr. 2001

  
• C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity

  小笠原史彦; 岡本雄介; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Expression and purification of a lipid efflux ABC protein aiming for Cryo-EM analysis

  小段篤史; 光岡薫; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Thermodynamic analysis of the enhancement of substrate-dependent ATPase activity of MDR1 by cholesterol.

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2021

  
• The analysis of the sterol specificity of human ABCA1 using liposomes

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Comparative analysis of the lipid composition of focal adhesion membrane and plasma membrane

  立花大; 箕浦広大; 長尾耕治郎; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• ヒトABCA1の活性誘導とステロール構造の関連解析

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  脂質生化学研究, 2021

  
• 多剤排出ポンプMDR1の薬剤絞り出しメカニズム

  小段篤史; 木村泰久; 植田和光

  トランスポーター研究会年会抄録集, 2020

  
• コレステロールによるMDR1の活性誘導とrhodamine化合物の構造関連性

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本生化学会大会(Web), 2020

  
• ABCA1のHDL産生活性およびコレステロールフロップ活性の調節

  岡本雄介; 小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2020

  
• HPLC-ELSDによるABCA1,ABCB4の脂質排出活性測定

  高橋智; 北悠人; 木岡紀幸; 木岡紀幸; 植田和光; 木村泰久

  トランスポーター研究会年会抄録集, 2020

  
• コレステロール輸送体ABCA1の生理的役割のメダカを用いた解析

  二股良太; 木下政人; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2020

  
• 巨大リポソーム(GUV)を用いたヒトABCA1の新規機能解析手法の開発

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  脂質生化学研究, 2020

  
• 巨大リポソーム(GUV)を用いたヒトABCA1の再構成系の開発

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本生化学会大会(Web), 2020

  
• 多剤排出ポンプMDR1の薬剤絞り出し機構

  小段篤史; 木村泰久; 植田和光

  ファルマシア(Web), 2020

  
• Establishment of an in vitro reconstitution system for nascent HDL formation.

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2020

  
• The Effect of Cholesterol on Substrate Transport of MDR1

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2020

  
• 硬さ感知・応答に関与する新規接着斑タンパク質の探索を目指したプロテオーム解析

  柴原正和; 立花大; 阿部雄一; 木村泰久; 植田和光; 木岡紀幸

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ABCA1とABCB4はアシル鎖非特異的にホスファチジルコリンを排出する

  高橋智; 木岡紀幸; 木岡紀幸; 植田和光; 木村泰久

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ELSD法を用いたヒトABCタンパク質の脂質輸送能解析手法の構築

  高橋智; 北悠人; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• ApoA-Iを封入した巨大リポソーム(GUV)の作製

  坂田和樹; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• ヒト多剤輸送体 P-糖タンパク質の酵素活性にコレステロールが与える影響の解析

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会関西支部講演会講演要旨集, 2019

  
• 極性脂質に含まれるヒトABCG4の輸送基質探索および認識機構の解析

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 細胞膜コレステロール濃度の上昇に依存したABCA1によるHDL産生速度の増加

  小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2019

  
• リン脂質輸送体ABCB4の第4膜貫通ヘリックスに存在するプロリンの機能解析

  小川峻; 末永健人; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 生化学的手法を基軸としたヒトABCタンパク質の機能解析

  木村泰久; 川野邊峻哲; 植田和光; 植田和光

  日本生化学会大会(Web), 2019

  
• 多剤輸送体P-glycoprotein(ABCB1)による薬剤輸送には2分子のATP結合・加水分解が共役する

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2019

  
• 接着斑細胞膜の単離手法の確立とビンキュリンの接着斑細胞膜への影響

  立花大; 柴原正和; 大町朋弘; 箕浦広大; 木村泰久; 植田和光; 木岡紀幸

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• HPLC-ELSDによるヒトABCタンパク質の脂質排出活性測定手法の確立

  高橋智; 北悠人; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会関西支部講演会講演要旨集, 2019

  
• ABCA1によるコレステロール輸送の生理的重要性

  小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  日本生化学会大会(Web), 2019

  
• ABCA1によるHDL産生活性は細胞膜コレステロール濃度に依存している

  小笠原史彦; 木村泰久; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2018

  
• コレステロール結合性細菌毒素ストレプトリジンOを用いたABCA1によるコレステロール輸送の証明

  小笠原史彦; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  脂質生化学研究, 2018

  
• 光反応性ホスファチジルコリンを用いた脂質抱合型apoA-Iの標識手法の確立

  藤本和希; 木村泰久; 安部真人; 三芳秀人; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2018

  
• ヒト由来浮遊培養細胞への遺伝子導入手法の検討

  木村泰久; 松尾道憲; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会関西支部講演会講演要旨集, 2018

  
• 生細胞膜上でヒト多剤輸送体MDR1(ABCB1)の構造変化の際にATPが果たす役割の解明

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• ABCG4が輸送する極性脂質中の未知基質の探索

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本生化学会大会(Web), 2018

  
• ABCAサブファミリータンパク質のC末端領域の機能解明を目的としたキメラタンパク質の解析

  岡本雄介; 永田紅; 笠井倫志; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• ヒト多剤輸送体(MDR1)の輸送基質取り込み機構の解析

  木村泰久; 井上修一; 末永健人; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• 超音波処理を用いた接着斑の単離

  柴原正和; 箕浦広大; 市川尚文; 木村泰久; 木村泰久; 植田和光; 植田和光; 木岡紀幸; 木岡紀幸

  日本生化学会大会(Web), 2018

  
• コレステロール結合性細菌毒素ストレプトリジンOを用いたABCA1によるコレステロール輸送の解析

  小笠原史彦; 木村泰久; 植田和光; 植田和光

  トランスポーター研究会年会抄録集, 2018

  
• ATP加水分解活性を指標としたヒトABCG4の輸送基質特異性解析

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 木村泰久

  トランスポーター研究会年会抄録集, 2018

  
• K_ATPチャネルの複合体安定性における薬剤とヌクレオチドの効果

  田中里実; 松尾道憲; 植田和光; 木村泰久

  トランスポーター研究会年会抄録集, 2018

  
• ABCA1とapoA-Iによるコレステロール排出メカニズム解明への新しい定量的アプローチ

  三好里奈; 小笠原史彦; 石神正人; 永田紅; 永田紅; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• コレステロール結合性細菌毒素ストレプトリジンOを用いたABCA1の機能解析

  小笠原史彦; 加納ふみ; 加納ふみ; 村田昌之; 村田昌之; 木村泰久; 植田和光; 植田和光

  日本生化学会大会(Web), 2017

  
• コレステロール結合性細菌毒素ストレプトリジンOを用いたABCタンパク質の機能解析

  小笠原史彦; 加納ふみ; 加納ふみ; 村田昌之; 村田昌之; 木村泰久; 植田和光; 植田和光

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2017

  
• 分子内FRETを用いたヒト多剤排出ポンプ(MDR1,ABCB1)の構造変化解析手法の確立

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ビネキシンのホスファチジン酸結合領域の解析

  伊藤有亮; 市川尚文; 折田雄一郎; 安部真人; 木村泰久; 植田和光; 植田和光; 三芳秀人; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• コレステロール認識配列CRACは,ヒトABCG4のコレステロール輸送において重要である

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 分子内FRETを用いたヒト多剤排出ポンプMDR1(ABCB1)の構造変化解析手法の確立

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2017

  
• ヒトABCB6によるポルフィリン認識機構の解析

  西澤奈美; 木村泰久; 大貫元; 木岡紀之; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 細胞-ECM間接着領域の細胞膜は脂質ラフト様の脂質組成を有する

  箕浦広大; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2017

  
• KATPチャネルの複合体安定性における薬剤とヌクレオチドの影響の解析

  田中里実; 松尾道憲; 植田和光; 木村泰久

  日本生化学会大会(Web), 2017

  
• ビネキシンαの両親媒性ヘリックスはビンキュリンの構造変化に必要である

  日野直也; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 間葉系幹細胞分化のレチノイン酸制御に与える接着斑タンパク質ビネキシンの影響

  高田恭子; 黒田美都; 黒田美都; 木村泰久; 植田和光; 植田和光; 木岡紀幸; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ヒトABCB6に存在する機能未知膜ドメイン(TMD0)の解析

  西澤奈美; 木村泰久; 大貫元; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• キノコ由来新規化合物がNPC1L1依存性コレステロール取込みに及ぼす影響

  千場智尋; 千場智尋; 櫻田剛史; 渡邊理恵; 山口宏二; 木村泰久; 木岡紀幸; 河岸洋和; 河岸洋和; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ビネキシンαとホスファチジン酸の相互作用解析

  伊藤有亮; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ヒトABCG4に存在するコレステロール認識配列の機能解析

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• HDL産生の鍵を握るABCA1のC末端領域の機能解析

  岡本雄介; 永田紅; 笠井倫志; 楠見明弘; 楠見明弘; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• 原子間力顕微鏡(AFM)観察に向けたABCタンパク質サンプルの最適化

  山原一晃; 木村泰久; 柴田幹大; 内橋貴之; 内橋貴之; 安藤敏夫; 安藤敏夫; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ヒトABCA1の細胞外ドメインに対するモノクローナル抗体の作製とエピトープ探索

  三好里奈; 富岡麻衣子; 小笠原史彦; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ABCA1細胞外ドメインのHDL産生における役割の解析

  小笠原史彦; 石神正登; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• 高速AFMによるABCタンパク質の動態観察

  滝ヶ浦尚平; 柴田幹大; 柴田幹大; 山原一晃; 木村泰久; 植田和光; 植田和光; 内橋貴之; 内橋貴之; 安藤敏夫

  日本生体エネルギー研究会討論会講演要旨集, 2016

  
• HDL産生におけるABCA1細胞外ドメインの脂質蓄積機能

  小笠原史彦; 石神正登; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2015

  
• ビンキュリンの細胞外マトリクスの硬さ感知にはアクチン繊維結合が必要である

  大町朋弘; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本生化学会大会(Web), 2015

  
• ABCG4のTM6に存在するCRAC domainの機能解析

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本生化学会大会(Web), 2015

  
• 2S2AM2 Molecular mechanism of ABC proteins involved in lipid homeostasis

  UEDA Kazumitsu

  日本生物工学会大会講演要旨集, 2007

  
• Inhibitory Action of Fomiroid A, A Novel Compound from the Mushroom, on Niemann-Pick C1-Like 1 (NPC1L1)-dependent Cholesterol Uptake

  千場 智尋; 河岸 洋和; 松尾 道憲; 植田 和光

  Bio industry = バイオインダストリー, Sep. 2015

  
• ヒト組織におけるABCA1,ABCA7蛋白の作用機構の解析

  戸田好信; 本庄原; 林田雅彦; 岡田光貴; 植田和光; 赤津裕康

  天理医療大学紀要, Mar. 2018

  
• ヒト,マウス組織におけるABCA1,ABCA7蛋白の作用機構の解析

  戸田好信; 赤津裕康; 植田和光

  臨床病理, Oct. 2017

  
• ヒトアルツハイマー病,アルツハイマー病モデルマウスにおける神経細胞,グリア細胞の動態,ABCA7蛋白発現に関する研究

  戸田好信; 末長敏彦; 林田雅彦; 岡田光喜; 池本正生; 植田和光; 赤津裕康

  天理医療大学紀要, Mar. 2017

  
• アルツハイマー病モデルマウス脳の神経細胞,グリア細胞におけるABCA7蛋白発現に関する研究

  戸田好信; 岡田光貴; 赤津裕康; 池本正生; 植田和光

  臨床病理, Sep. 2016

  
• Effect of nicotine on expression of ABCA7 in the brain of model mice with Alzheimer’s disease.

  戸田好信; 富岡麻衣子; 岡田光貴; 赤津裕康; 植田和光

  天理医療大学紀要, Aug. 2016

  
• X線自由電子レーザーを用いたP糖タンパク質ホモログの連続フェムト秒X線結晶構造解析

  大山諒; 潘東青; 中津亨; 佐藤友美; 山口知宏; 小段篤史; 植田和光; 岩田想; 加藤博章

  第14回次世代を担う若手のためのフィジカル・ファーマフォーラム（PPF2016）, Aug. 2016

  
• ヌクレオチド依存的なATP感受性カリウムチャンネルの構造変化

  木村泰久; 菅野亮; 松尾道憲; 加藤博章; 光岡薫; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2016

  
• Crystallographic study of the ABC transporter CmABCB1 covalently bound to substrate derivatives

  Matsuoka, K; Hirokane, R; Kodan, A; Yamaguchi, T; Nakatsu, T; Ueda, K; Kato, H

  6th Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases (ABC2016), Mar. 2016

  
• 真核生物由来ABC輸送体の分子機構

  小段篤史; 植田和光; 加藤博章

  日本生化学会大会(Web), 2016

  
• アルツハイマー病脳の神経細胞,グリア細胞におけるABCA7蛋白発現に関する研究

  戸田好信; 岡田光貴; 赤津裕康; 池本正生; 植田和光

  臨床病理, Oct. 2015

  
• アルツハイマー病モデルマウスの神経細胞,グリア細胞におけるニコチンの効果に関する研究

  戸田好信; 竹田真由; 岡田光貴; 赤津裕康; 池本正生; 植田和光

  日本病理学会会誌, Mar. 2015

  
• Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.

  L. Tomiyama; T. Sezaki; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• Distribution of vinculin to lipid rafts is involved in sensing ECM stiffness

  A. Nagasato; H. Yamashita; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• Comparison of the effect of the vinexin family proteins on vinculin-mediated mechanosensing.

  T. Ichikawa; M. Kita; T. Sezaki; S. Chiang; A. R. Saltiel; Y. Kimura; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• ABC多剤排出トランスポーターの立体構造の特徴

  山口知宏; 小段篤史; 中津亨; 植田和光; 加藤博章

  第87回日本生化学会大会, 15 Oct. 2014

  
• 喫煙者,非喫煙者アルツハイマー病脳の神経細胞,グリア細胞におけるABCA7蛋白発現に関する研究

  戸田好信; 竹田真由; 岡田光喜; 赤津裕康; 池本正生; 植田和光

  臨床病理, Oct. 2014

  
• ABC protein involved in membrane lipid transport

  植田 和光; 冨岡 麻衣子

  医学のあゆみ, 29 Mar. 2014

  
• 喫煙者,非喫煙者アルツハイマー病脳組織におけるABCA7蛋白発現及びグリア細胞に関する研究

  戸田好信; 竹田真由; 赤津裕康; 池本正生; 植田和光

  日本病理学会会誌, Mar. 2014

  
• Crystal structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Sakiyama; Christopher J. Hipolito; Akane Fujioka; Ryo Hirokane; Yasuhisa Kimura; Hiroaki Suga; Kazumitsu Ueda; Hiroaki Kato

  ABC2014, 5th FEBS Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Mar. 2014

  
• Structure-based functional aspects of the ABC multidrug transporter, CmABCB1 from a thermophilic eukaryote

  Tomohiro Yamaguchi; Atsushi Kodan; Toru Nakatsu; Keita Sakiyama; Christopher J. Hipolito; Akane Fujioka; Ryo Hirokane; Yasuhisa Kimura; Hiroaki Suga; Kazumitsu Ueda; Hiroaki Kato

  ABC2014, 5th FEBS Special Meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Mar. 2014

  
• Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agro chemicals (vol 38, pg 112, 2013)

  Satoshi Kanaoka; Yasuhisa Kimura; Masaaki Fujikawa; Yoshiaki Nakagawa; Kazumitsu Ueda; Mild Akamatsu

  JOURNAL OF PESTICIDE SCIENCE, 2014

  
• ABCA7の脳特異的発現および細胞内局在の免疫組織化学的解析

  戸田好信; 國領久美子; 富岡麻衣子; 橋詰良夫; 赤津裕康; 植田和光

  臨床病理, Oct. 2012

  
• トランスポーターにおけるATP駆動力共役メカニズムの立体構造基盤

  山口知宏; 小段篤史; 中津亨; 藤岡あかね; 植田和光; 加藤博章

  公開シンポジウム「ゆらぎと水―生命のエネルギーと機能の分子機構を探る」, Sep. 2012

  
• 結晶構造に基づく多剤排出型ABCトランスポーターメカニズムの解明

  藤岡あかね; 山口知宏; 小段篤史; 中津亨; 植田和光; 加藤博章

  次世代を担う若手ファーマ・バイオフォーラム講演要旨集,11th,49, Sep. 2012

  
• X-ray crystallographic analysis of an exporter-type ABC transporter

  Atsushi Kodan; Tomohiro Yamaguchi; Toru Nakatsu; Keita Sakiyama; Akane Fujioka; Kazumitsu Ueda; Hiroaki Kato

  ABC2012, the 4th FEBS Special Meeting “ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease” Hotel Grauer Bär (Innsbruck, Austria), Mar. 2012

  
• Regulation of Cholesterol Homeostasis by ABCA1

  長尾 耕治郎; 植田 和光

  細胞工学, 2012

  
• Vinexin-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions.

  H. Yamashita; A. Nagasato; T. Ichikawa; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• Roles of Dlg5, a Crohn's disease associated protein, as a regulator of TGF-beta signals and epithelial to mesenchymal transition

  T. Sezaki; K. Inada; L. Tomiyama; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• Vinculin-vinexin alpha interaction plays a key role in sensing extracellular matrix stiffness

  T. Ichikawa; H. Yamashita; Y. Kimura; I. Harada; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• 好熱性紅藻由来ABCトランスポーターの輸送基質特異性の検討

  山口知宏; 木村泰久; 小段篤史; 池口圭司; 渡辺文太; 平竹潤; 中津亨; 植田和光; 加藤博章

  生体膜と薬物の相互作用シンポジウム講演要旨集,34th,120-121, 2012

  
• K_ATPチャネル複合体の精製および単粒子構造解析

  KANNO RYO; KIMURA YASUHISA; MATSUO MICHINORI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2011

  
• 好熱性真核生物由来の多剤排出ABCトランスポーターの機能解析

  山口知宏; 崎山慶太; 地主遼平; 佐藤友美; 小段篤史; 中津亨; 植田和光; 加藤博章

  日本薬学会年会要旨集,131st,3,116, 2011

  
• 好熱性紅藻由来の基質排出型ABCトランスポーターの基質特異性の解析

  山口知宏; 崎山慶太; 佐藤友美; 小段篤史; 中津亨; 植田和光; 加藤博章

  日本蛋白質科学会年会プログラム・要旨集,11th,134, 2011

  
• PKA forms a complex with WAVE2 and controls lamellipodia formation

  YAMASHITA Hiroshi; UEDA Kazumitsu; KIOKA Noriyuki

  日本細胞生物学会大会要旨集, 07 May 2010, Peer-reviewed

  
• ヒト培養細胞発現系を用いたKATPチャネル複合体の精製および機能評価

  KIMURA YASUHISA; KANNO RYO; MATSUO MICHINORI; MITSUOKA KAORU; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2010

  
• Structural study of ATP-sensitive potassium channel using the electron microscopy

  KANNO Ryo; KANNO Ryo; KIMURA Yasuhisa; MITSUOKA Kaoru; UEDA Kazumitsu

  生化学, 2010, Peer-reviewed

  
• 好熱性紅藻Cyanidioschyzon merolae由来のABCトランスポーターの発現,精製,及び機能解析

  崎山慶太; 山口知宏; 小段篤史; 中津亨; 佐藤友美; 植田和光; 加藤博章

  日本蛋白質科学会年会プログラム・要旨集,10th,162, 2010

  
• 好熱性紅藻由来ABCトランスポーターの多剤排出活性の特徴

  山口知宏; 崎山慶太; 池口圭司; 地主遼平; 佐藤友美; 渡辺文太; 小段篤史; 中津亨; 平竹潤; 植田和光; 加藤博章

  生体膜と薬物の相互作用シンポジウム講演要旨集,32nd,61-62, 2010

  
• Isolation and biochemical characterization of an ABC transporter from a thermophilic red alga, Cyanidioschyzon merolae

  YAMAGUCHI Tomohiro; SAKIYAMA Keita; KODAN Atsushi; NAKATSU Toru; UEDA Kazumitsu; KATO Hiroaki

  第31回生体膜と薬物の相互作用シンポジウム講演要旨集, Nov. 2009

  
• ヒト培養細胞を用いたATP感受性カリウムチャネルの大量発現・精製手法の開発

  KIMURA YASUHISA; HIRAYAMA HIROSHI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 25 Sep. 2009

  
• ヒト培養細胞を用いたATP感受性カリウムチャネル複合体の大量生産,高純度精製

  KIMURA YASUHISA; HIRAYAMA YUJI; MATSUO MICHINORI; KIOKA NORIYUKI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• 多剤排出トランスポーターP糖タンパク質のリンカー領域の薬物輸送における役割

  佐藤友美; 小段篤史; 木村泰久; 植田和光; 中津亨; 加藤博章

  日本薬学会年会要旨集,129th,4,256, 2009

  
• メタノール資化性酵母Pichia pastorisを用いたABCタンパク質の大量生産

  小段篤史; 崎山慶太; 山口知宏; 中津亨; 植田和光; 加藤博章

  生化学,ROMBUNNO.2P-332, 2009

  
• C末端の二本のαヘリックスの欠失による大腸菌由来ABCトランスポーターMsbA結晶の改良

  寺角香菜子; 小段篤史; 中野博明; 木村泰久; 中津亨; 植田和光; 加藤博章

  生化学,ROMBUNNO.2P-316, 2009

  
• ヒト培養細胞を用いたヒトABCタンパク質大量発現・精製手法の構築

  KIMURA YASUHISA; HIRAYAMA YUJI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会関西支部講演会講演要旨集, 10 Sep. 2008

  
• Enhanced clustering of .ALPHA.5 integrin and fibronectin fibrillogenesis in vinexin deficient mouse embryonic fibroblasts

  TAKAHASHI Honami; TAKEGAMI Megumi; SOGABE Takayuki; UEDA Kazumitsu; KIOKA Noriyuki

  日本細胞生物学会大会要旨集, 05 Jun. 2008, Peer-reviewed

  
• ヒト培養細胞を用いたヒトABCトランスポーターの大量発現系の構築および精製条件スクリーニング手法の開発

  KIMURA YASUHISA; HIRAYAMA YUJI; ASAMI NARUMI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 2008

  
• BIOFLO310を用いた大腸菌高密度培養による膜タンパク質の効率的生産系

  KODAN ATSUSHI; TERAKADO KANAKO; SUEGAMI SHINJI; KUBO TAKESHI; UEDA KAZUMITSU; NISHIKAWA SHIGEMICHI; KATO HIROAKI

  生化学, 2008

  
• 結晶化に適した好熱菌由来ABCトランスポーターのスクリーニング

  佐藤友美; 中津亨; 植田和光; 加藤博章

  日本薬学会年会要旨集,128th,4,65, 2008

  
• 構造解析に適した真核生物由来のABCトランスポーターのスクリーニング

  崎山慶太; 木村泰久; 小段篤史; 中津亨; 植田和光; 加藤博章

  日本薬学会年会要旨集,128th,4,65, 2008

  
• ABCB4(MDR2)による胆汁酸依存的な脂質排出

  森田 真也; 小林 綾; 松尾 道憲; 高根沢 康一; 新井 洋由; 北河 修治; 植田 和光

  薬剤学: 生命とくすり, 10 May 2007

  
• MDR2(ABCB4)による胆汁酸依存的なリン脂質とコレステロールの排出

  森田 真也; 小林 綾; 松尾 道憲; 高根沢 康一; 新井 洋由; 北河 修治; 植田 和光

  日本薬学会年会要旨集, Mar. 2007

  
• MDR2発現細胞によるリン脂質とコレステロールの排出

  森田 真也; 小林 綾; 松尾 道憲; 高根沢 康一; 新井 洋由; 植田 和光

  脂質生化学研究, May 2006

  
• Focal adhesion protein vinexin interacts with and stabilizes Wasp-family verprolin-homologous protein (WAVE) 2

  Masaru Mitushima; Takuhito Sezaki; Rje Akahane; Kazumitsu Ueda; Shiro Suetsugu; Tadaomi Takenawa; Noriyuki Kioka

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• 昆虫細胞Sf+を用いたヒトP糖タンパク質の大量精製

  TERAKADO KANAKO; KODAN ATSUSHI; SATO TOMOMI; SHIBATA HIROYUKI; UEDA KAZUMITSU; KATO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2005

  
• ERK2 activated by EGF and cell adhesion interacts with and phosphorylates vinexin

  O. Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  CELL STRUCTURE AND FUNCTION, May 2004

  
• Functional analysis of ABCA3, an ABC protein highly expressed in alveolar type II cells

  Koh Nagata; Michinori Matsuo; Noriyuki Kioka; Nobuhiro Ban; Nobuya Inagaki; Kazumitsu Ueda

  CELL STRUCTURE AND FUNCTION, May 2004

  
• ABCA7 expression induces apolipoprotein-mediated HDL generation in the absence of ABCA1

  S Abe-Dohmae; Y Ikeda; M Hayashi; K Ueda; S Yokoyama

  ATHEROSCLEROSIS SUPPLEMENTS, Sep. 2003

  
• Dominant expression of ATP binding cassette transporter A1 on basolateral surface of human intestinal epithelium

  T Ohama; K Hirano; Z Zhang; K Tsujii; Y Nakagawa-Toyama; A Matsuyama; M Ishigami; N Sakai; H Hiraoka; K Ueda; S Yamashita; Y Matsuzawa

  ATHEROSCLEROSIS SUPPLEMENTS, Sep. 2003

  
• Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis. (vol 278, pg 8815, 2003)

  AR Tanaka; S Abe-Dohmae; T Ohnishi; R Aoki; G Morinaga; K Okuhira; Y Ikeda; F Kano; M Matsuo; N Kioka; T Amachi; M Murata; S Yokoyama; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003

  
• Pichia pastorisのペキソファジーに関与する新規ABCタンパク質Paz17

  永田紅; 大西智裕; 向山博幸; 奥公秀; 加藤暢夫; 阪井康能; 松尾道憲; 植田和光; 天知輝夫

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• Detection of ABC proteins in plant cells by vanadate-induced nucleotide trapping and its application

  K Terasaka; N Shitan; F Sato; F Maniwa; K Ueda; K Yazaki

  PLANT AND CELL PHYSIOLOGY, 2003

  
• 酵母ペルオキシソーム膜タンパク質Pmp47の生化学的特徴

  阪井康能; 福田克治; 中川智行; 植田和光; 加藤暢夫

  日本農芸化学会関西支部講演会講演要旨集, 02 Feb. 2002

  
• ABC タンパク質による生体防御

  植田 和光

  日本農芸化学会誌, 05 Mar. 2001

  
• ヒトMDR1の昆虫細胞での大量発現,精製及びATP加水分解活性の測定

  KIMURA YASUHISA; MORINAGA MANABU; MATSUO MICHINORI; MATSUMOTO TAKASHI; KATO HIROAKI; KIOKA NORIYUKI; AMACHI TERUO; UEDA KAZUMITSU

  日本農芸化学会誌, 05 Mar. 2001

  
• Functional analysis of a mutant sulphonylurea receptor associated with a mild form of persistent hyperinsulinaemic hypoglycaemia of infancy

  S Trapp; P Jones; M Matsuo; T Amachi; K Ueda; Y Tanizawa; Y Oka; FM Ashcroft

  JOURNAL OF PHYSIOLOGY-LONDON, Sep. 2000

  
• 新生児低血糖症患者のSUR1遺伝子変異は,NBFへのアデニンヌクレオチドの協調的結合を障害する (Diabetes Frontier)

  谷澤幸生; 松田万幸; 松尾道憲; 太田康晴; 井上寛; 植田和光; 岡芳知

  Diabetes Frontier, 2000

  
• P-glycoprotein is neither a volume-sensitive Cl- channel nor a protein kinase C-mediated regulator

  Y Okada; M Tominaga; A Miwa; T Tominaga; K Ueda

  JOURNAL OF PHYSIOLOGY-LONDON, May 1996

  
• EXPRESSION OF THE HUMAN MDR-1 (MULTIDRUG-RESISTANCE) GENE

  K UEDA; D CLARK; IB RONINSON; MM GOTTESMAN; PASTAN, I

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1987

  
• Analyses of chimera proteins of ABCA1 suggest the importance of the C-terminal domain of ABCA2 and ABCA13, linked to the Alzheimer’s disease and schizophrenia

  〇Yusuke Okamoto; Koh Nagata; Rinshi Kasai; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• Live cell analysis of the conformational changes in human multidrug transporter MDR1

  〇Ryota Futamata; Fumihiko; Ogasawara; Takafumi Ichikawa; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• キメラタンパク質を用いたABCAサブファミリータンパク質のC末端領域の機能解析

  岡本雄介; 永田紅; 笠井倫志; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会 2018年度大会

  
• 超音波処理を用いた接着斑単離法の確立

  柴原正和; 市川尚文; 箕浦広大; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会 2018年度大会

  
• リン脂質輸送体ABCB4の 基質取り込みゲートの解析

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  日本農芸化学会 2018年度大会

  
• 間葉系幹細胞の細胞外基質の硬さに対する応答におけるSORBSファミリータンパク質の役割

  黒田美都; 植田和光; 木岡紀幸

  日本農芸化学会 2018年度大会

  
• ヒト多剤排出ポンプMDR1 (ABCB1)の構造変化において ATPが果たす役割の検討

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会2018年度名古屋大会

  
• ヒトABCB4の第4膜貫通ヘリックスの機能解析

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  2017年度生命科学系学会合同年次大会

  
• ABCA1は細胞内でコレステロールを動かすことによって細胞遊走を制御する

  伊藤志帆; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会

  
• 接着斑タンパク質ビネキシンがレチノイン酸により制御される間葉系幹細胞分化に与える効果

  高田恭子; 黒田美都; 木村泰久; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• 接着斑タンパク質ビネキシンおよびCAPはYAP/TAZの核局在を調節する

  黒田美都; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• 細胞外マトリックスの硬さによる細胞分化制御へのビンキュリンーYAP/TAZ系の関与

  黒田美都; 市川尚文; 長里彩花; 大町朋弘; 木村泰久; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• ポルフィリンのカルボキシル基はヒトABCB6によるポルフィリン認識に重要である

  西澤奈美; 木村泰久; 大貫元; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会, 2017

  
• 定量的アプローチによるABCA1とapoA-Iによる脂質排出メカニズムの解明

  三好里奈; 小笠原史彦; 石神正登; 永田紅; 木村泰久; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会

  
• ヒトABCB4の基質取り込み経路の検討

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会

  
• 分子内FRETを用いたヒト多剤排出ポンプMDR1(ABCB1)変異体の構造変化解析

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会

  
• 間葉系幹細胞の脂肪細胞分化におけるビネキシンファミリータンパク質の役割

  黒田美都; 植田和光; 木岡紀幸

  第22回アディポサイエンス・シンポジウム

  
• 細胞遊走とコレステロール合成に与えるABCA1の影響

  伊藤志帆; 木岡紀幸; 植田和光

  第69回日本細胞生物学会大会

  
• ビンキュリンは細胞外基質の硬さに応じてTAZの核局在を促進し、脂肪細胞への分化 を抑制する

  黒田美都; 和田洋樹; 植田和光; 木岡紀幸

  第69回日本細胞生物学会大会

  
• 細胞外基質の硬さの感知と収縮力発生におけるビネキシンファミリータンパク質の役割

  市川尚文; 喜多真弘; 植田和光; 木岡紀幸

  第69回日本細胞生物学会大会

  

Books and Other Publications

• ABCトランスポーター-生体防御のABC-遺伝子から疾患まで.

  植田 和光

  診断と治療社,, 2002, Not refereed

  
• MDR1遺伝子を介した多剤耐性.In癌の薬剤耐性とその克服-基礎と臨床,大沼尚夫,and竹村譲eds.

  植田 和光

  宇宙堂八木書店,/,63-72, 2001, Not refereed

  
• ガン細胞の薬剤耐性機構

  植田 和光

  In動物細胞細胞工学ハンドブック:朝倉書店,, 2001, Not refereed

  
• Cell volume regulation. The molecular mechanism and volume sensing machinery. (共著)

  植田 和光

  Volume sesor anion channel.,, 1998, Not refereed

  
• How does P-gp recognize its substrates? (共著)

  植田 和光

  Seminars in Cancer Biology,, 1997, Not refereed

  
• Role of P-glycoprotein in the transport of hormones and peptides.

  植田 和光

  Multidrug resistance in cancer cells. (共著),, 1996, Not refereed

  
• 多剤耐性の分子機構

  植田 和光

  羊土社, 1994, Not refereed

  
• Substrates for P-glycoprotein in kidney

  植田 和光

  Transports in the liver (共著),/,223-232, 1994, Not refereed

  
• 脂溶性酸化物のDNA損傷作用及び脂溶性有害物質排出ポンプPー糖蛋白質(共著)

  植田 和光

  食品の生体調節機能,/,319-330, 1993, Not refereed

  
• ABCタンパク質:細胞のATPエンジン.In生体膜のエネルギー装置

  植田 和光

  バイオサイエンスの新世紀 共立出版,7, Not refereed

  

Awards

• 1992

  日本農芸化学会, 日本農芸化学会奨励賞
• Mar. 2010

  日本農芸化学会, 日本農芸化学会賞
• Jul. 2017

  科学技術分野の文部科学大臣表彰科学技術賞

External funds: Kakenhi

• Uncovering the secrets of lipid-transporting ABC proteins

  Grant-in-Aid for Scientific Research (S)

  Broad Section F

  Kyoto University

  Kazumitsu Ueda

  From 11 Jun. 2018, To 31 Mar. 2023, Project Closed

  ABC蛋白質;コレステロール;HDL;動脈硬化症;精神疾患;不妊;ABCA1;輸送酵素;細胞内輸送;Aster-A;細胞膜ー小胞体コンタクトサイト;メダカ;生殖反応;動脈硬化;Aster;ABCA13;統合失調症;神経細胞;ノックアウトマウス;トランスポーター;細胞接着;アルツハイマー病;神経変性疾患;構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H05269/
• HDL(善玉コレステロール)形成の鍵をにぎるABC蛋白質の作用機構解明

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  植田 和光

  From 01 Apr. 2013, To 31 Mar. 2014, Discontinued

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25252019/
• Molecular mechanism of ABC proteins involved in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu Ueda

  From 31 May 2013, To 31 Mar. 2018, Project Closed

  ABC蛋白質;トランスポーター;コレステロール;動脈硬化;アルツハイマー病;増殖シグナル;結晶構造解析;iPS細胞;神経細胞;1分子生物学;構造生物学;膜環境;多能性幹細胞;阻害剤;中枢神経細胞;3次元構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25221203/
• 脂質恒常性維持の空間的・時間的制御システム

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  植田 和光

  From 01 Apr. 2008, To 31 Mar. 2009, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20248035/
• Physiological substrates and functions of ABC proteins involved in lipid transport

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu UEDA

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  動物生化学;膜輸送タンパク質;ABC蛋白質;動脈硬化;アルツハイマー病;コレステロール;膜タンパク質;神経疾患;生活習慣病;1分子イメージング;ABCタンパク質;善玉コレステロール;ケミカルライブラリー;iPS細胞;ES細胞;1分子観察;トランスポーター;核内受容体;蛋白質相互作用;ACBタンパク質;アルツハイマー;タンパク質精製;プロテアソーム;遺伝病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20228001/
• PhYsiological function of focal adiesion protein vinexin

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Noriyuki KIOKA

  From 01 Apr. 2004, To 31 Mar. 2008, Project Closed

  細胞運動;創傷治癒;上皮間葉転換;細胞接着;シグナル伝達;がん;再生医学;ビネキシン;細胞骨格;分化;アクチン;浸潤;足場依存性, Cell Adhesion;Wound healing;Tumorigenesis;Migration;Signal transduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380229/
• Molecular mechanism of ATP-dependent transporters involvedinl in lipid homeostasis in brain

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kazumitsu UEDA

  From 01 Apr. 2004, To 31 Mar. 2008, Project Closed

  脳;コレステロール;ABC蛋白質;脂質;トランスポーター;生活習慣病;アルツハイマー;スフィンゴミエリン;ABCA1;ABCG1;HDL;ABCタンパク質;アルツハイマー病;膜蛋白質;自己免疫疾患;ATPase;α1-シントロフィン, brain;cholesterol;ABC proteins;lipids;transporters;lifestyle associated diseases;Alzheimer disease;sphingomyelin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380070/
• Molecular Basis of Novel Membrane Transport Mechanism

  Grant-in-Aid for Creative Scientific Research

  Kyoto University;Akita University

  Nobuya INAGAKI

  From 01 Apr. 2003, To 31 Mar. 2008, Project Closed

  遺伝子;蛋白質;脂質;ABC蛋白質;膜輸送;イオンチャネル, gene;protein;lipid;ABC protein;membrane transport;ion channel

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15GS0301/
• ABCGタンパク質複合体の品質管理機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  松尾 道憲

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  ABCタンパク質;ABCG;小胞体;コレステロール;品質管理;膜タンパク質複合体;リン脂質;二量体;RXR配列

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15032224/
• ABC蛋白の多機能性と生命維持機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  植田 和光

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  ABC蛋白質;生活習慣病;コレステロール;糖尿病;癌;トランスポーター;ABCタンパク質;チャネル;動脈硬化;膜タンパク質;構造解析;遺伝病;ATP;レセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10217101/
• Analysis of physiological function of a focal adhesion protein vinexin

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Noriyuki KIOKA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  細胞接着;ビネキシン;ビンチュリン;足場依存性;裏打ちタンパク質;ビンキュリン;細胞骨格;アクチン;裏打ち蛋白質, Cell Adhesion;Vinexin;Vinculin;Anchorage-dependence;foal adhesion protein

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14560287/
• Molecular mechanism of ATP-dependent transporters involved in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  コレステロール;トランスポーター;ABCタンパク質;動脈硬化;3次元構造解析;高脂血症;ABCA1;糖尿病;生活習慣病;リン脂質;構造解析, ABC proteins;cholesterol;atherosclerosis;α1-syntrophin;lipid;HDL;transporter;membrane

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14360053/
• 細胞の増殖シグナル及び癌の浸潤転移における新規裏打蛋白質ビネキシンの機能解析

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  細胞接着;ビンキュリン;足場依存;細胞増殖;MAPキナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12215075/
• Comprehensive study on the regulation of metabolism of lipids including long-chain fatty acids and very-long-chain faty acids

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Teruo AMACHI

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  脂肪酸;コレステロール;リン脂質;ABCタンパク質;トランスポーター;ペルオキシソーム;ABCA1;動脈硬化;ATP;遺伝子;クローニング;ベーター酸化, fatty acids;cholesterol;phospholipids;ABC proteins;transporter;peroxisome;ABCA1;atherosclerosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11460044/
• 裏打蛋白ビネキシンとSosの相互作用からみた細胞骨格とシグナル伝達のクロストーク

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  SH3;Signal Transduction;JNK;Sos;vinculin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11160208/
• ABC蛋白の機能の多様性の分子基盤

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  植田 和光

  From 01 Apr. 1998, To 31 Mar. 2003, Project Closed

  ABCタンパク質;トランスポーター;チャネル;動脈硬化;膜タンパク質;コレステロール;自己免疫疾患;生活習慣病;糖尿病;癌;遺伝病;ATP;レセプター;残耐射性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10217205/
• 抗癌剤排出ポンプP-糖蛋白質、MRP、cMOATの基質認識と輸送機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  植田 和光

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  癌;多剤耐性;P-糖蛋白質;MDR1;MRP;ATP;トランスポーター;SUR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10153228/
• A novel signal transduction mechanism via intracellular ATP sensor

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  ABCタンパク質;トランスポーター;K^+チャネル;CFTR;MDRI;SUR;シグナル伝達;ATP;P-糖タンパク質;MDR;MRP;糖尿病;癌;ABCス-パファミリー;k^+チャネル;多剤耐性;分子生物学;生化学, ABC proteins;transporter;K^+ channel;CFTR;MDRI;SUR;signal transductron;ATP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660086/
• Channel-Transporter Correlation

  Grant-in-Aid for Scientific Research on Priority Areas

  Okazaki National Research Institutes

  Yasunobu OKADA

  From 01 Apr. 1995, To 31 Mar. 1999, Project Closed

  イオンチャネル;水チャネル;トランスポータ;カルシウムポンプ;構造・機能相関;クローニング, ion channel;water channel;transporter;Ca pump;structure-function relation;cloning

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07276103/
• ATP駆動型トランスポータとチャネルの構造・機能協関

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1995, To 31 Mar. 1998, Project Closed

  ATP;チャネル;トランスポーター;分子生物学;電気生理学;糖尿病;脳;心臓;トランスポータ;抗がん剤耐性;膜輸送体;イオン;抗癌剤;ポンプ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07276101/
• Pharmacokinetic Studies on Drug Excretion Mechanism Mediated by P-Glycoprotein

  Grant-in-Aid for General Scientific Research (C)

  KOBE UNIVERSITY

  Yusuke TANIGAWARA

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  P糖蛋白質;MDR;シクロスポリン;PSC 833;耐性克服;薬物動態;ドキソルビシン;多剤耐性;薬物排泄;抗がん剤;薬剤耐性;トランスポーター, P-glycoprotein;MDR;Cyclosporin;PSC 833;Reversal of resistance;Pharmacokinetics;Doxorubicin;Multidrug resistance

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06672233/
• チャネルとトランスポータの構造・機能協関

  Grant-in-Aid for Co-operative Research (B)

  Okazaki National Research Institutes

  岡田 泰伸

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  チャネル;イオンチャネル;水チャネル;トランスポータ;キャリア;ポンプ;膜輸送;重点領域研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06354030/
• P糖蛋白質を分子標的とする耐性克服治療システムの開発とその臨床応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  癌治療;多剤耐性;P糖蛋白;抗癌剤;薬物動態;MDR1;転写制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06282229/
• 臨床応用可能な抗がん剤耐性マーカーの探索とその克服

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyushu University

  桑野 信彦

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  抗がん剤耐性;多剤耐性;P-糖蛋白;MDRI;MRP;耐性克服;シスプラチン耐性;DNAトポイソメラーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06282115/
• P糖蛋白質の物質輸送およびチャネル活性とATP加水分解の共役

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  多剤耐性;P-糖蛋白質;MDR1遺伝子;癌;トランスポーター;ATPase;クロライドチャネル;酵母

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05259214/
• P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  P糖蛋白質;多剤耐性;癌;抗癌剤;トランスポーター;癌遺伝子;ステロイドホルモン;シクロスポリンA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05152066/
• Molecular mechanism of steroid transporter P-glycoprotein

  Grant-in-Aid for General Scientific Research (C)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 1992, To 31 Mar. 1994, Project Closed

  P-糖蛋白質;多剤耐性;MDR1遺伝子;ステロイドホルモン;物質輸送;分子生物学;癌;トランスポーター;ジゴキシン, P-glycoprotein;Multidrug resistance;Steroid hormone;MDR1 gene;Cancer;Transporter;Chemotherapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04660085/
• 抗がん性抗生物質によるDNA分子の微細構造の認識、修飾並びに活性変動

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  駒野 徹

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  活性酸素;DNA鎖切断;ブレオマイシン作用;塩濃度とDNAの構造;DNAの高次構造;遷移金属と切断効果

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04220221/
• P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  多剤耐性;Pー糖蛋白質;MDR1遺伝子;遺伝子発現;癌遺伝子;分子生物学;免疫抑制剤;物質輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04152066/
• 抗がん性抗生物質によるDNA分子の微細構造の認識と修飾及び活性変動

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  駒野 徹

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  活性酸素;DNA鎖切断;アルカリ不安定部位;ブレオマイシン作用;塩濃度とブレオマイシン;遷移金属イオンの効果

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03236221/
• 新しい制がん剤耐性遺伝子群の解析と克服法の確立

  Grant-in-Aid for Cancer Research

  大分医科大学

  桑野 信彦

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  抗癌剤耐性;耐性獲得機序;耐性克服剤開発;多剤耐性遺伝子;Pー糖蛋白;DNAトポイソメラ-ゼ;シスプラチン;5ーフルオロウラシル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03151051/
• Mechanism of the ATP-dependent membrane transporter

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  Kazumitsu UEDA

  From 01 Apr. 1990, To 31 Mar. 1992, Project Closed

  Pー糖タンパク質;ATPase;膜タンパク質;輸送タンパク質;融合タンパク質;多剤耐性;嚢胞性繊維症;培養細胞;膜輸送蛋白質;Pー糖蛋白質;襄胞性繊維症;リン脂質;融合蛋白質;酵母, Transmembrane protein;P-glycoprotein;Cystic fibrosis;Multidrug resistance;ATPase;Fusion protein;Cultured cell;Transport protein

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02660091/
• Development and application of new regulatory genes

  Grant-in-Aid for General Scientific Research (A)

  Kyoto University

  Tohru KOMANO

  From 01 Apr. 1990, To 31 Mar. 1994, Project Closed

  複製開始領域;Btのプロモーター;SSIシグナル;熱ショックレスポンス;多剤耐性;糖鎖工学;DNA合成開始領域;プライマ-ゼ結合部位;ステム・ル-プ構造;転写調節機構;CRP結合部位;部位特異的変異;融合遺伝子;転写調節部位, Replication initiation region;Promoter of BT;SSI signal;Heat shock response;Multi-drug resistance;Glyco-technology

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02403023/
• 色々な機能を持つ食品成分の体内輸送へのPー糖蛋白質の関与の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1990, To 31 Mar. 1991, Project Closed

  Pー糖蛋白質;ビタミンD_2;膜輸送蛋白質;砒素;遺伝子発現;ストレス;食品;酵母

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02218208/
• 新しい制がん剤耐性遺伝子群の解析と克服法の確立

  Grant-in-Aid for Cancer Research

  大分医科大学

  桑野 信彦

  From 01 Apr. 1990, To 31 Mar. 1993, Project Closed

  耐性獲得;多剤耐性遺伝子;Pー糖蛋白;耐性克服;DNAトポイソメラ-ゼ;メタロチオネイン;グルタチオン・チオ-ル・トランスフェラ-ゼ;5ーフルオロウラシル耐性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02151053/
• 食品含有不飽和脂肪酸の劣化産物によって導入れさるDNA損傷および細胞変異の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1989, To 31 Mar. 1990, Project Closed

  過酸化脂質;DNA損傷;変異;酸素シジカル;過酸化水素;アスコルビン酸;ベンツピレン;MDRI遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01636506/
• 遺伝子改変による多剤耐性を担うMDR蛋白の機能と解析と耐性克服への応用

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1989, To 31 Mar. 1990, Project Closed

  多剤耐性;MDR1遺伝子;Pー糖蛋白質;遺伝子改変;癌;融合蛋白;発現制御;酵母内発現

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01015052/
• 副腎中で発現しているMDRcDNAの単離とMDR蛋白の大腸菌中での生産

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  植田 和光

  From 01 Apr. 1988, To 31 Mar. 1989, Project Closed

  Pー糖蛋白質;MDR;遺伝子;多剤耐性;副腎;動物培養細胞;ステロイドホルモン;酵母内発現;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63560083/
• 遺伝子改変による多剤耐性を担うヒトMDR蛋白の機能の解析

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1988, To 31 Mar. 1989, Project Closed

  多剤耐性;P-糖蛋白質;MDR1遺伝子;動物培養細胞;酵母内発現;薬剤結合活性;遺伝子改変;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63015045/
• Analysis of insecticidal -endotoxin protein genes and the modification of insecticidal activity by mutagenesis

  Grant-in-Aid for General Scientific Research (B)

  Kyoto University

  Tohru KOMANO

  From 01 Apr. 1987, To 31 Mar. 1990, Project Closed

  BTトキシン;delta-エンドトキシン;BTトキシン遺伝子;130kDa遺伝子;殺虫活性領域;組換えプラスミド;ISRH3;ISRH4;δ-エンドトキシン;殺虫性タンパク質;δーエンドトキシン;Bacillus thuringiensis var israelensisの殺虫性タンパク質;130kDaタンパク質遺伝子;BTIの殺虫性タンパク質遺伝子;BTの130kDaタンパク質遺伝子;130kDaタンパク質遺伝子の構造, BT toxin;delta-endotoxin;BT toxin genes;130 kDa protein genes;Insecticidal domain;Recombinant plasmid;ISRH3;ISRH4

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62470120/
• Direct visualization of ABCA1-mediated HDL formation

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  植田 和光

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ABCA1;HDL;高速AFM;クライオEM;コレステロール;クライオEMによる構造解析;動脈硬化症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00326/

External funds: others

• Molecular mechanism of multidrug transporter P-glycoprotein
• Molecular mechanism of ATP sensitine K⁺ channel
• Molecular mechanism of ABC proteins
• 脂質ホメオスタシスに関与するABC蛋白質の分子基盤

Education

Teaching subject(s)

• From Apr. 2011, To Mar. 2012

  応用生命科学入門III

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  分子生物学II

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  細胞生化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  細胞生化学専攻演習

  農学研究科
• From Apr. 2011, To Mar. 2012

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Integrated Cell-Material Sciences

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2013, To Mar. 2014

  Cellular Biochemistry

  Fall, 農学研究科
• From Apr. 2013, To Mar. 2014

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Integrated Cell-Material Sciences

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Applied Biochemistry

  Fall, 農学研究科
• From Apr. 2014, To Mar. 2015

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Applied Life Sciences

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Integrated Cell-Material Sciences

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Integrated Cell-Material Sciences

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Applied Biochemistry

  Fall, 農学研究科
• From Apr. 2016, To Mar. 2017

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Applied Biochemistry

  Fall, 農学研究科
• From Apr. 2018, To Mar. 2019

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences III

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Outline of Physiological Chemistry

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry

  Spring, 農学研究科