Basic Information

Faculty

• Faculty of Engineering

Email Address

• Email Address

  matsuda.shyun.2xkyoto-u.ac.jp

Professional Memberships

• To Present

  The Japanese Environmental Mutagen and Genome Society

Academic Degree

• 24 Mar. 2008

  京都大学修士（工学）
• 24 Sep. 2012

  京都大学博士（工学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科博士後期課程都市環境工学専攻, 修了
• 京都大学, 大学院工学研究科修士課程都市環境工学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部地球工学科, 卒業

Research History

• From Apr. 2024, To Present

  Kyoto University, Laboratories for Environmental Health, Department of Environmental Engineering, Graduate School of Engineering, Associate Professor
• From Nov. 2022, To Mar. 2024

  DAIICHI SANKYO COMPANY, LIMITED, Senior Researcher
• From Jan. 2016, To Oct. 2022

  FUJIFILM Corporation, 研究員
• From Apr. 2014, To Dec. 2015

  Kyoto University, Graduate School of Engineering, Research Fellow
• From Oct. 2012, To Mar. 2014

  Japan Society for the Promotion of Science, Research Fellowship for Young Scientists PD)
• From Apr. 2012, To Sep. 2012

  Japan Society for the Promotion of Science, Research Fellowship for Young Scientists (DC2)
• From Mar. 2009, To Sep. 2009

  Kyoto University, Graduate School of Engineering, 研究員
• From Apr. 2008, To Feb. 2009

  Taiho Pharmaceutical Co., Ltd.

ID,URL

• ORCID ID

  0000-0002-4181-2772

• J-Global ID

  202401005517665433

• Researcher number

  41001209

researchmap URL

• https://researchmap.jp/shunmatsuda

Research

Research Interests

• Pyruvate kinase M2
• Arylhydrocarbon receptor
• LC-MS/MS
• DNA damage response
• Genotoxicity

Research Areas

• Environmental science/Agricultural science, Environmental effects of chemicals, 環境毒性学

Papers

• Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation

  Tomoya Hotani; Motonari Goto; Yukie Otsuki; Shun Matsuda; Nobuhiro Wada; Masakazu Shinohara; Tomonari Matsuda; Masayuki Yokoi; Kaoru Sugasawa; Yuki Ohsaki; Wataru Sakai

  05 Feb. 2025

  
• Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

  Satoshi Kitazawa; Yukiko Ishii; Keiko Makita-Suzuki; Koichi Saito; Kensuke Takayanagi; Hiromi Sugihara; Shun Matsuda; Takayuki Yamakawa; Yasuhiro Tsutsui; Tadashi Tanaka; Tomohisa Hatta; Tohru Natsume; Toru Kondo; Yuichi Ishikawa; Shinji Hagiwara; Hitoshi Kiyoi

  Blood, 13 Nov. 2019, Peer-reviewed

  
• Abstract 1228: FF-10850, a novel liposomal topotecan, achieved superior anti-tumor effects and a favorable safety profile via preferential distribution followed by dual payload release mechanisms in tumor

  Susumu Shimoyama; Ken Okada; Toshifumi Kimura; Noriyuki Kasagi; Shinji Nakayama; Keiko Makita-Suzuki; Shun Matsuda; Mikinaga Mori; Kiyohito Takada; Shinji Hagiwara; Takefumi Hara

  Cancer Research, 01 Jul. 2019, Peer-reviewed

  
• Absolute quantification of DNA damage response proteins

  Shun Matsuda; Tsuyoshi Ikura; Tomonari Matsuda

  Genes and Environment, 18 Dec. 2023, Peer-reviewed, Lead author

  
• Detection of DNA damage formation by natural organic matter using EGFP-fused MDC1-expressing cells

  Kentaro Misaki; Tomonari Matsuda; Taketoshi Kusakabe; Yoshihisa Shimizu

  Chemosphere, Nov. 2019, Peer-reviewed

  
• Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells

  Smile Echizenya; Yukiko Ishii; Satoshi Kitazawa; Tadashi Tanaka; Shun Matsuda; Eriko Watanabe; Masao Umekawa; Shunsuke Terasaka; Kiyohiro Houkin; Tomohisa Hatta; Tohru Natsume; Yoshimasa Maeda; Shin-Ichi Watanabe; Shinji Hagiwara; Toru Kondo

  Neuro-Oncology, 10 Sep. 2019, Peer-reviewed

  
• Quantitative analysis of γH2AX reveals distinct responses in multiple mouse organs after administration of mitomycin C or ethyl methanesulfonate

  Shun Matsuda; Sayaka Wanibuchi; Toshihiko Kasahara

  Mutagenesis, 31 Dec. 2018, Peer-reviewed, Lead author, Corresponding author

  
• Simultaneous and absolute quantification of nucleoside triphosphates using liquid chromatography–triple quadrupole tandem mass spectrometry

  Shun Matsuda; Toshihiko Kasahara

  Genes and Environment, Dec. 2018, Peer-reviewed, Lead author, Corresponding author

  
• High-content image analysis (HCIA) assay has the highest correlation with direct counting cell suspension compared to the ATP, WST-8 and Alamar blue assays for measurement of cytotoxicity.

  Tahara H; Matsuda S; Yamamoto Y; Yoshizawa H; Fujita M; Katsuoka Y; Kasahara T

  Journal of pharmacological and toxicological methods, Nov. 2017, Peer-reviewed

  
• DNA damage assessment by visualization and quantification of DNA damage response

  松田 俊; 井倉 毅; 松田 知成

  Radiation Biology Research Communications, 31 Mar. 2017, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Chemically induced strong cellular hypertrophy often reduces the accuracy of cytotoxicity measurements obtained using the ATP assay.

  Tahara H; Yamamoto Y; Matsuda S; Yoshizawa H; Fujita M; Hioki T; Kasahara T

  The Journal of toxicological sciences, 2017, Peer-reviewed

  
• Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.

  Matsuda S; Matsuda Y; Yanagisawa SY; Ikura M; Ikura T; Matsuda T

  Jun. 2016, Peer-reviewed, Lead author

  
• Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin

  Masae Ikura; Kanji Furuya; Shun Matsuda; Ryo Matsuda; Hiroki Shima; Jun Adachi; Tomonari Matsuda; Takuma Shiraki; Tsuyoshi Ikura

  Molecular and Cellular Biology, 01 Dec. 2015, Peer-reviewed

  
• Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

  Shun Matsuda; Jun Adachi; Masaru Ihara; Nobuhiro Tanuma; Hiroshi Shima; Akira Kakizuka; Masae Ikura; Tsuyoshi Ikura; Tomonari Matsuda

  Nucleic Acids Research, 23 Sep. 2015, Peer-reviewed, Lead author

  Access this paper :

  
• Mutation assay using single-molecule real-time (SMRTTM) sequencing technology

  Tomonari Matsuda; Shun Matsuda; Masami Yamada

  Genes and Environment, 01 Sep. 2015, Peer-reviewed

  Access this paper :

  
• hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair.

  Okimoto S; Sun J; Fukuto A; Horikoshi Y; Matsuda S; Matsuda T; Ikura M; Ikura T; Machida S; Kurumizaka H; Miyamoto Y; Oka M; Yoneda Y; Kiuchi Y; Tashiro S

  Jun. 2015, Peer-reviewed

  
• Absolute quantification of acetylation and phosphorylation of the histone variant H2AX upon ionizing radiation reveals distinct cellular responses in two cancer cell lines

  Shun Matsuda; Kanji Furuya; Masae Ikura; Tomonari Matsuda; Tsuyoshi Ikura

  Radiation and Environmental Biophysics, 19 Jun. 2015, Peer-reviewed, Lead author

  
• Absolute quantification of γH2AX using liquid chromatography-triple quadrupole tandem mass spectrometry.

  Matsuda S; Ikura T; Matsuda T

  May 2015, Peer-reviewed, Lead author

  
• Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.

  Amanuma Y; Ohashi S; Itatani Y; Tsurumaki M; Matsuda S; Kikuchi O; Nakai Y; Miyamoto S; Oyama T; Kawamoto T; Whelan KA; Nakagawa H; Chiba T; Matsuda T; Muto M

  2015, Peer-reviewed

  Access this paper :

  
• An Easy-to-use Genotoxicity Assay Using EGFP-MDC1-expressing Human Cells

  Shun Matsuda; Ryo Matsuda; Yoko Matsuda; Shin-ya Yanagisawa; Masae Ikura; Tsuyoshi Ikura; Tomonari Matsuda

  Genes and Environment, 2014, Peer-reviewed, Lead author

  
• A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair

  Tomida, Junya; Itaya, Akiko; Shigechi, Tomoko; Unno, Junya; Uchida, Emi; Ikura, Masae; Masuda, Yuji; Matsuda, Shun; Adachi, Jun; Kobayashi, Masahiko; Meetei, Amom Ruhikanta; Maehara, Yoshihiko; Yamamoto, Ken-ichi; Kamiya, Kenji; Matsuura, Akira; Matsuda, Tomonari; Ikura, Tsuyoshi; Ishiai, Masamichi; Takata, Minoru

  Nucleic Acids Research, 2013, Peer-reviewed

  Access this paper :

  
• Genotoxicity of Colloidal Fullerene C-60

  Matsuda, S; Matsui, S; Shimizu, Y; Matsuda, T

  Environmental Science & Technology, 2011, Peer-reviewed, Lead author

  
• Lipid Peroxidation Generates Body Odor Component trans-2-Nonenal Covalently Bound to Protein in Vivo

  Ishino, K; Wakita, C; Shibata, T; Toyokuni, S; Machida, S; Matsuda, S; Matsuda, T; Uchida, K

  Journal of Biological Chemistry, 2010, Peer-reviewed

  Access this paper :

  
• Detection of Lipid Peroxidation-Induced DNA Adducts Caused by 4-Oxo-2(E)-nonenal and 4-Oxo-2(E)-hexenal in Human Autopsy Tissues

  Chou, PH; Kageyama, S; Matsuda, S; Kanemoto, K; Sasada, Y; Oka, M; Shinmura, K; Mori, H; Kawai, K; Kasai, H; Sugimura, H; Matsuda, T

  Chemical Research in Toxicology, 2010, Peer-reviewed

  Access this paper :

  

Misc.

• 塩基除去修復因子チミンDNAグリコシラーゼの構造活性相関と機能制御

  中村知史; 中村知史; 村上浩一; 村上浩一; 松田俊; 松田知成; 上原芳彦; 小野哲也; 西谷秀男; 菅澤薫; 菅澤薫

  日本生化学会大会(Web), Dec. 2015

  
• ゲノムストレス応答における普遍性と多様性の相互転換 DNA損傷応答における動的クロマチン平衡とその意義

  井倉 毅; 古谷 寛治; 松田 俊; 松田 知成; 松田 涼; 田代 聡; 井倉 正枝

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Invited

  
• 環境・衛生 miRNAイソ型の発現パターンでがんの種類を判別する

  松田 俊

  ファルマシア, Nov. 2017

  
• M2型ピルビン酸キナーゼによる増殖細胞特異的なAhRの機能制御

  松田俊; 松田俊

  Endocrine Disrupter News Letter, 2017

  
• 遺伝子制御の新たな主役 栄養シグナル 第1章 新たに見えてきた,栄養・代謝物シグナルによる遺伝子制御メカニズム 6.核内のピルビン酸キナーゼM2による転写調節機構

  松田知成; 松田俊; 松田俊; 井倉毅

  実験医学, 2016

  
• 増殖細胞特異的なAhRの機能制御

  松田俊; 松田俊

  環境ホルモン学会研究発表会プログラム・要旨集, 2016

  
• Validation of usefulness for multiple item measurable-cytotoxicity assay using image analysis. Comparison of various conventional cytotoxicity assays

  TAHARA Haruna; YAMAMOTO Yusuke; YOSHIZAWA Hiroe; MATSUDA Shun; FUJITA Masaharu; KATSUOKA Yasuhiro; KASAHARA Toshihiko

  Annual Meeting of the Japanese Society of Toxicology, 2016

  
• P-098(O-11) Absolute quantification of DNA repair and DNA damage-response proteins and histone modifications using LC/MS/MS(Poster Sessions)

  Matsuda,Shun; Ikura,Masae; Furuya,Kanji; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 24 Nov. 2015

  
• P-094(O-12) Mutation assay using SMRT DNA sequencer(Poster Sessions)

  Matsuda,Tomonari; Matsuda,Shun; Yamada,Masami

  日本環境変異原学会大会プログラム・要旨集, 24 Nov. 2015

  
• ピルビン酸キナーゼとピルビン酸デヒドロゲナーゼ複合体によるアセチルCoAの地産地消モデル

  松田俊; 足立淳; 井原賢; 田沼延公; 島礼; 垣塚彰; 井倉正枝; 井倉毅; 松田知成

  日本生化学会大会(Web), 2015

  
• Diversity and dynamics analysis of phosphorylation and acetylation of histone H2AX by absolute quantification

  Matsuda Shun; Furuya Kanji; Ikura Masae; Ikura Tsuyoshi; Matsuda Tomonari

  Abstracts for Annual Meeting of Japanese Proteomics Society, 2015

  
• P-034 Detection of DNA Damage Response Inhibition Using EGFP-MDC1-expressing Cells(Poster Sessions)

  Matsuda,Shun; Yanagisawa,Sin-ya; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 31 Oct. 2014

  
• P-014(O-3) Development of a Simple Mutagenicity Test Using eGFP-MDC1-expressing Cells(Poster presentation)

  Matsuda,Shun; Ikura,Masae; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 30 Oct. 2013

  
• P-063(O-6) Pyruvate Kinase Type M2 Acts as a Coactivator of Dioxin Receptor(IV. Functional Analysis,Poster Presentation)

  Matsuda,Shun; Adachi,Jun; Ihara,Masaru; Tanuma,Nobuhiro; Shima,Hiroshi; Ikura,Masae; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本分子生物学会年会プログラム・要旨集(Web), 29 Oct. 2012

  
• P-087 Analysis of the MLH1 complexes by BN/SDS-PAGE(Poster Presentation)

  Takeuchi,Tomoki; Matsuda,Shun; Adachi,Jun; Hattori,Tomomi; Ikura,Masae; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 20 Oct. 2011

  
• P-101 Functional Interaction between Pyruvate Kinase and Dioxin Receptor(Poster Presentation)

  Matsuda,Shun; Adachi,Jun; Ihara,Masaru; Tanuma,Nobuhiro; Shima,Hiroshi; Ikura,Masae; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 20 Oct. 2011

  
• P-074(O-4) Proteomic Analysis for Arylhydrocarbon Receptor (AhR) Complex(Poster Presentation)

  Matsuda,Shun; Adachi,Jun; Ihara,Masaru; Ikura,Masae; Ikura,Tsuyoshi; Matsuda,Tomonari

  日本環境変異原学会大会プログラム・要旨集, 29 Oct. 2010

  
• フラーレンのin vitro毒性評価—Toxicity of fullerene in vitro—京都大学環境衛生工学研究会 第30回シンポジウム講演論文集

  松田 知成; 松田 俊; 足立 淳

  環境衛生工学研究 = Environmental & sanitary engineering research : 京都大学環境衛生工学研究会機関誌, Jul. 2008

  

Presentations

• DNA損傷応答の定量化と可視化に関する研究

  松田俊

  日本環境変異学会第46回大会, Invited

  
• DNA損傷応答の可視化と絶対定量による遺伝毒性評価

  松田俊

  日本環境変異学会 平成29年度公開シンポジウム「若手が拓く環境変異原研究」, 10 Jun. 2017, Invited

  
• 増殖細胞特異的なAhR機能制御

  松田俊

  環境ホルモン学会第19回研究発表会, Invited

  

Books and Other Publications

• 遺伝情報の発現制御 : 転写機構からエピジェネティクスまで

  Latchman, David S.; 五十嵐, 和彦; 深水, 昭吉; 山本, 雅之, Joint translation, 第3章 遺伝子調節におけるクロマチン構造の役割

  メディカル・サイエンス・インターナショナル, Feb. 2012

  Find Kyoto University's collection of books :

  

Industrial Property Rights

• WO/2023/132338, 特願2022-001248, METHOD AND KIT FOR IDENTIFYING SUGAR-BOUND AMINO ACID SITE IN PROTEIN

  Shun Matsuda

  
• 特許第7126556号, JP2019038117, シタラビンを含む抗腫瘍剤、シタラビンと併用される抗腫瘍効果増強剤、抗腫瘍用キット、およびシタラビンと併用される抗腫瘍剤

  北澤 諭; 石井 由紀子; 齊藤 耕一; 松田 俊

  
• 特許第7369143号, JP2019050578, ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるRNAウイルス感染症治療剤

  米納 孝; 中谷 俊幸; 栗本 佑介; 松田 俊; 伴 寿一

  
• WO2020-138067, JP2019050578, ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるRNAウイルス感染症治療剤

  米納 孝; 中谷 俊幸; 栗本 佑介; 松田 俊; 伴 寿一

  
• WO2020-067412, JP2019038117, シタラビンを含む抗腫瘍剤、シタラビンと併用される抗腫瘍効果増強剤、抗腫瘍用キット、およびシタラビンと併用される抗腫瘍剤

  北澤 諭; 石井 由紀子; 齊藤 耕一; 松田 俊

  
• 特開2020-005581, 特願2018-130624, γH2AXを定量する方法、ヒストン含有試料を調製する方法、およびその利用

  松田 俊

  
• 特開2019-211217, 特願2018-104340, ヌクレオチドの定量方法

  松田 俊

  

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Enivironmental Engineering Lab.

  F470, Fall, Graduate School of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Environmental Health, Adv.

  A626, Spring, Graduate School of Engineering, 2

Academic, Social Contribution

Committee Memberships

• From Apr. 2025, To Present

  編集幹事, 京都大学衛生工学研究会
• From Apr. 2022, To Present

  Editorial Board, Genes and Environment
• From Apr. 2022, To Present

  The Publications Committee (1st), The Japanese Environmental Mutagen and Genome Society
• From Jan. 2021, To Dec. 2024

  The Publications Committee (2nd), The Japanese Environmental Mutagen and Genome Society
• From Nov. 2018, To Nov. 2018

  Executive Committee of 47th Annual Meeting of the Japanese Environmental Mutagen Society, The Japanese Environmental Mutagen Society