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Sugiyama, Hiroshi

Institute for Advanced Study

Sugiyama, Hiroshi
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    Last Updated :2025/05/27

    Basic Information

    Faculty

    • 理学部

    Concurrent Affiliation

    • Institute for Advanced Study, 物質－細胞統合システム拠点, 連携主任研究者

    Professional Memberships

    • アメリカ化学会
    • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
    • THE BIOPHYSICAL SOCIETY OF JAPAN
    • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
    • KINKI CHEMICAL SOCIETY, JAPAN
    • THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN
    • THE JAPANESE CANCER ASSOCIATION
    • THE PHARMACEUTICAL SOCIETY OF JAPAN
    • THE CHEMICAL SOCIETY OF JAPAN
    • 日本光医学・光生物学会

    Academic Degree

    • Master of Engineering(Kyoto University)
    • Ph.D(Kyoto University)

    Research History

    • From Apr. 2022, To Present
      物質ー細胞統合システム拠点, 特任教授
    • From Apr. 2008, To Mar. 2018
      Kyoto University, 物質-細胞統合システム拠点, 主任研究員
    • From Apr. 2003, To Mar. 2022
      Kyoto University, Graduate School of Science, 教授
    • From Apr. 1999, To Mar. 2003
      Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, 教授
    • From Nov. 1996, To Mar. 1999
      Tokyo Medical and Dental University, 医用器材研究所, 教授
    • From Mar. 1993, To Oct. 1996
      Kyoto University, Faculty of Engineering, 助教授
    • From Apr. 1987, To Feb. 1993
      Kyoto University, Faculty of Engineering, 助手
    • From Apr. 1986, To Mar. 1987
      米国ヴァージニア大学, 日本学術振興会特別研究員
    • From Apr. 1984, To Mar. 1986
      米国ヴァージニア大学, 博士研究員

    Profile

    • Profile

      核酸についてケミカルバイオロジー研究を進めている。有機合成化学、分子生物学、分子シミュレーションの手法を用いて、遺伝子発現の化学的な原理の解明を目指している。現在、京都大学高等研究院で進めている主な研究テーマは、（１）人工遺伝子スイッチの設計と評価、（２）ミトコンドリアのG4と進化の関連が挙げられる。

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        Chemical Biology of DNA

      • Overview of the research

        Professor Sugiyama's research interests involve the bioorganic chemistry of nucleic acids. Using the tools of synthetic physical organic chemistry and molecular biology, the Sugiyama group is defining the chemical principles underlying the recognition, reactivity and structure of nucleic acids. There are no other research groups on such a general and fundamental aspect of nucleic acids as a substance.The group utilizes a chemical approach in following areas: Molecular mechanism of DNA modification by DNA base alkylation, hydrogen abstraction and charge transfer. Design of highly efficient sequence-specific DNA acting agents based on understanding of the action mechanism of antitumor antibiotics. Design of unnatural nucleic acid for understanding of nucleic acid structure and function. Development of a method probing DNA local conformation in vivo. The long-range goal is creation of artificial genetic switches for targeted cell differentiation and treatment of many diseases.

      Research Interests

      • 核酸化学
      • ケミカルバイオロジー

      Research Areas

      • Life sciences, Bioorganic chemistry, nucleic acids

      Papers

      • Cancer Accumulation and Anticancer Activity of "CROX (Cluster Regulation of RUNX)" PIP in HER2-Positive Gastric Cancer Evaluated by Chicken Egg Cancer Model.
        Tatsuya Masuda; Takayoshi Watanabe; Yasutoshi Tatsumi; Jason Lin; Kazuhiro Okumura; Toshinori Ozaki; Hiroshi Sugiyama; Yasuhiko Kamikubo
        Cancer medicine, Apr. 2025
      • NIR-Induced Photoswitching Hybrid DNA Nanoconstruct-Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate
        Thanapat Pongkulapa; Ji Hye Yum; Callan D. Mcloughlin; Brandon Conklin; Tomotaka Kumagai; Li Ling Goldston; Hiroshi Sugiyama; Soyoung Park; Ki-Bum Lee
        SMALL, 25 Feb. 2025
      • Evaluation of anti-cancer activity of the inhibitors against RUNX and p300 based on the CAM model
        Takayoshi Watanabe; Tatsuya Masuda; Yasutoshi Tatsumi; Utomo Rohmad; Hiroshi Sugiyama; Meiyanto Edy; Yasuhiko Kamikubo
        CANCER SCIENCE, Jan. 2025
      • Modulation of Excimer Formation and Photoexcitation Behaviour through DNA-Surfactant-Dye Supramolecular Assembly
        Dan Bai; Wenxuan Zhao; Huhu Feng; Hiroshi Sugiyama
        MACROMOLECULAR MATERIALS AND ENGINEERING, May 2024
      • CROX (Cluster Regulation of RUNX) strategy against MYCN-amplified neuroblastoma through p53-mediated apoptosis
        Tatsuya Masuda; Yasutoshi Tatsumi; Takayoshi Watanabe; Toshinori Ozaki; Kazuma Nakatani; Ummi Zulfin; Yusuke Suenaga; Yoshitaka Hippo; Hiroshi Sugiyama; Yasuhiko Kamikubo
        CANCER SCIENCE, Mar. 2024
      • The use of Chorioallantoic membrane from fertilized chicken eggs as an anticancer drug evaluation system
        Takayoshi Watanabe; Tatsuya Masuda; Yasutoshi Tatsumi; Utomo Rohmad; Zulfin Ummi; Meiyanto Edy; Yoshitaka Hippo; Hiroshi Sugiyama; Yasuhiko Kamikubo
        CANCER SCIENCE, Mar. 2024
      • RNA G-quadruplex in functional regulation of noncoding RNA: Challenges and emerging opportunities
        Vinodh J. Sahayasheela; Hiroshi Sugiyama
        CELL CHEMICAL BIOLOGY, 18 Jan. 2024
      • Follow your interests and use anything for research
        Hiroshi Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2024
      • Nucleic acid assembled semiconducting materials: Rational design, structure-property modulation, and performance evaluations
        Dan Bai; Wenxuan Zhao; Huhu Feng; Hiroshi Sugiyama
        APL MATERIALS, 01 Oct. 2023
      • DNA Methylation Modification Patterns Identify Distinct Prognosis and Responses to Immunotherapy and Targeted Therapy in Renal Cell Carcinoma
        Dan Bai; Yan Cheng; Xiaolan Lu; Ganesh Pandian Namasivayam; Hiroshi Sugiyama
        FRONTIERS IN BIOSCIENCE-LANDMARK, Sep. 2023
      • Novel Auger-Electron-Emitting 191Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma
        Honoka Obata; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Kaori Hashiya; Hayato Ikeda; Masatoshi Itoh; Katsuyuki Minegishi; Kotaro Nagatsu; Mikako Ogawa; Toshikazu Bando; Hiroshi Sugiyama; Ming-Rong Zhang
        Pharmaceuticals, 27 Oct. 2023
      • Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.
        Kenta Kurayoshi; Yusuke Takase; Masaya Ueno; Kumiko Ohta; Kyoko Fuse; Shuji Ikeda; Takayoshi Watanabe; Yuki Nishida; Shin-Ichi Horike; Kazuyoshi Hosomichi; Yuichi Ishikawa; Yuko Tadokoro; Masahiko Kobayashi; Atsuko Kasahara; Yongwei Jing; Mahmoud I Shoulkamy; Makiko Meguro-Horike; Kensuke Kojima; Hitoshi Kiyoi; Hiroshi Sugiyama; Hiroki Nagase; Atsushi Tajima; Atsushi Hirao
        Cell Death & Disease, Sep. 2023, Peer-reviewed
      • Artificial intelligence in microbial natural product drug discovery: current and emerging role
        Vinodh J. Sahayasheela; Manendra B. Lankadasari; Vipin Mohan Dan; Syed G. Dastager; Ganesh N. Pandian; Hiroshi Sugiyama
        Natural Product Reports, 2022
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      • Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator: MitoScript
        Yang, L.; Rathnam, C.; Hidaka, T.; Hou, Y.; Conklin, B.; P; ian, G.N.; Sugiyama, H.; Lee, K.-B.
        Nano Letters, 2022
      • Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma
        Dan Bai; Huhu Feng; Jiajun Yang; Aiping Yin; Xiao Lin; Airong Qian; Hiroshi Sugiyama
        Molecular Therapy - Nucleic Acids, 03 Sep. 2021
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      • Controlling the function of genes and biologically active nucleic acids
        Makiya Nishikawa; Hiroshi Sugiyama
        Advanced Drug Delivery Reviews, 01 Jul. 2019
      • DNAオリガミを用いた直行性を有する転写デバイスの合理的設計
        増渕 岳也; 遠藤 政幸; 飯塚 怜; 井口 彩香; Yoon Dong; 関口 哲志; Qi Hao; 飯沼 良介; 宮薗 侑也; 庄子 習一; 船津 高志; 杉山 弘; 原田 慶恵; 上田 卓也; 多田隈 尚史
        生命科学系学会合同年次大会, Dec. 2017
      • RUNX1によるE-selectinの転写制御は血管ニッチにおいて白血病の治療標的となる
        徳重 智恵子; 森田 剣; 前田 信太郎; 清瀬 大樹; 能浦 三奈; 片岡 竜貴; 杉山 弘; 上久保 靖彦; 足立 壮一
        日本癌学会総会記事, Sep. 2017
      • Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals
        Katsuhiko Abe; Haruhiko Eki; Yuki Hirose; Soyoung Park; Shanmugavel Chinnathambi; Ganesh Pandian Namasivayam; Kazuki Takeda; Hiroshi Sugiyama; Masayuki Endo
        Molecules, 01 Oct. 2024
      • Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands
        Deepak Karna; Lin Liang; Grinsun Sharma; Shankar Mandal; Sefan Asamitsu; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Hanbin Mao
        Nucleic Acids Research, 01 Sep. 2024
      • Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation.
        T. Bando; A. Narita; I. Saito; H. Sugiyama
        Nucleic acids research. Supplement (2001), 2001
      • A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures
        Mitsuharu Ooga; Vinodh Sahayasheela; Yuki Hirose; Daisuke Sasaki; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chemical Communications, 2024
      • Integrated analysis of immune-related gene subtype and immune index for immunotherapy in clear cell renal cell carcinoma
        Dan Bai; Suna Chen; Huhu Feng; Aiping Yin; Juncheng Lu; Yiran Ma; Hiroshi Sugiyama
        Pathology Research and Practice, 01 Sep. 2021
      • Tropylium derivatives as new entrants that sense quadruplex structures
        Daisuke Hori; Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park
        Bulletin of the Chemical Society of Japan, 01 Jul. 2021
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      • Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs
        Wen Ann Wee; Ji Hye Yum; Shingo Hirashima; Hiroshi Sugiyama; Soyoung Park
        RSC Chemical Biology, 01 Jun. 2021
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      • Folding RNA–Protein Complex into Designed Nanostructures
        Tomonori Shibata; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito
        Methods in Molecular Biology, 2021
      • Histidine-conjugated DNA as a biomolecular depot for metal ions
        Soyoung Park; Haruka Matsui; Koyuki Fukumoto; Ji Hye Yum; Hiroshi Sugiyama
        RSC Advances, 06 Mar. 2020
      • Telomeric quadruplexes as therapeutic targets
        Sefan Asamitsu; Norifumi Shioda; Hiroshi Sugiyama
        Annual Reports in Medicinal Chemistry, 01 Jan. 2020
      • Epigenetic drug discovery by artificial genetic switches
        Toshikazu Bando; Hiroshi Sugiyama
        Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2020
      • Chb-M', an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in p53-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo.
        Yuki Hirose; Shinsuke Sato; Kaori Hashiya; Mitsuharu Ooga; Toshikazu Bando; Hiroshi Sugiyama
        Journal of medicinal chemistry, 27 May 2024
      • Structural Studies of a Complex of a CAG/CTG Repeat Sequence-Specific Binding Molecule and A-A-Mismatch-Containing DNA.
        Katsuhiko Abe; Yuki Hirose; Tomotaka Kumagai; Kaori Hashiya; Kumi Hidaka; Tomoko Emura; Toshikazu Bando; Kazuki Takeda; Hiroshi Sugiyama
        JACS Au, 27 May 2024
      • Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells.
        Yuki Hirose; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Journal of medicinal chemistry, 14 Sep. 2023
      • Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effect
        Yusuke Kawamoto; You Wu; Soyoung Park; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura
        Chemical Communications, 2024
      • DNA折り紙上の異なった方式による遺伝子転写ナノデバイスの理論的な設計(Rational design of orthogonal gene transcription nano device on DNA origami)
        増渕 岳也; 多田隈 向史; 飯塚 怜; 遠藤 政幸; 船津 高志; 杉山 弘; 原田 慶恵; 上田 卓也
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity
        Hirohito Kubota; Kana Furuichi; Tatsuya Masuda; Toshiya Tatsuta; Hidefumi Hiramatsu; Junko Takita; Sugiyama Hiroshi; Souichi Adachi; Yasuhiko Kamikubo
        Blood, 13 Nov. 2019
      • 遺伝子スイッチ法を用いたRUNXクラスター制御がもたらす強力な抗癌作用(RUNX cluster regulation by GENE SWITCH triggers a profound tumor regression of diverse origins)
        Morita Ken; Suzuki Kensho; Maeda Shintaro; Mitsuda Yoshihide; Tokushige Chieko; Kashiwazaki Gengo; Taniguchi Junichi; Maeda Rina; Noura Mina; Hirata Masahiro; Kataoka Tatsuki; Kiyos Hiroki; Tokumasu Mayu; Matsuo Hidemasa; Matsuo Akihiko; Tanaka Sunao; Okuno Yasushi; Muto Manabu; Naka Kazuhito; Ito Kosei; Kitamura Toshio; Kaneda Yasufumi; Liu Paul P.; Bando Toshikazu; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi
        臨床血液, Sep. 2017
      • RUNX1によるE-selectinの転写制御は血管ニッチにおいて白血病の治療標的となる(RUNX1 enhances leukemia cell engraftment in the vascular niche through up-regulating E-selectin)
        Tokushige Chieko; Morita Ken; Maeda Shintaro; Kiyose Hiroki; Noura Mina; Bando Toshikazu; Hirata Masahiro; Kataoka Tatsuki; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi
        臨床血液, Sep. 2017
      • 急性骨髄性白血病においてRUNX1、p53、CBFBは細胞自律性のフィードバックループを構成する(Cell-autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells)
        Noura Mina; Morita Ken; Tokushige Chieko; Maeda Shintaro; Bando Toshikazu; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi
        臨床血液, Sep. 2017
      • Nucleic acid‐based small molecules as targeted transcription therapeutics for immunoregulation
        Dan Bai; Reihane Ziadlou; Thangavel Vaijayanthi; Subramani Karthikeyan; Shanmugavel Chinnathambi; Anutthaman Parthasarathy; Li Cai; Marie‐Charlotte Brüggen; Hiroshi Sugiyama; Ganesh N. Pandian
        Allergy, 06 Dec. 2023
      • Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs
        Thangavel Vaijayanthi; Ganesh N. Pandian; Hiroshi Sugiyama
        Advanced Therapeutics, Jul. 2023
      • A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models.
        Susumu Ikenoshita; Kazuya Matsuo; Yasushi Yabuki; Kosuke Kawakubo; Sefan Asamitsu; Karin Hori; Shingo Usuki; Yuki Hirose; Toshikazu Bando; Kimi Araki; Mitsuharu Ueda; Hiroshi Sugiyama; Norifumi Shioda
        The Journal of clinical investigation, 14 Sep. 2023
      • Structural Expansion of Catalytic RNA Nanostructures through Oligomerization of a Cyclic Trimer of Engineered Ribozymes
        Mst. Ayesha Siddika; Hiroki Oi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Molecules, 06 Sep. 2023
      • Isothermal self-assembly of multicomponent and evolutive DNA nanostructures
        Caroline Rossi-Gendron; Farah El Fakih; Laura Bourdon; Koyomi Nakazawa; Julie Finkel; Nicolas Triomphe; Léa Chocron; Masayuki Endo; Hiroshi Sugiyama; Gaëtan Bellot; Mathieu Morel; Sergii Rudiuk; Damien Baigl
        Nature Nanotechnology, 31 Jul. 2023
      • Two-Dimensional DNA Origami Lattices Assembled on Lipid Bilayer Membranes
        Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo
        Methods in Molecular Biology, 12 May 2023
      • Mitochondria and G-quadruplex evolution: an intertwined relationship
        Vinodh J. Sahayasheela; Zutao Yu; Takuya Hidaka; Ganesh N. Pandian; Hiroshi Sugiyama
        Trends in Genetics, Jan. 2023, Peer-reviewed, Last author, Corresponding author
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      • Corrigendum to "Chlorambucil-conjugated PI-polyamide (Chb-M'), a transcription inhibitor of the RUNX family, has anti-tumor activity against SHH-type medulloblastoma with p53 mutation" [Biochem. Biophys. Res. Commun. 620 (10 September 2022) 150-157].
        Yasuzumi Matsui; Yohei Mineharu; Yuki Noguchi; Etsuko Yamamoto Hattori; Hirohito Kubota; Masahiro Hirata; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo
        Biochemical and biophysical research communications, 14 May 2023
      • Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition
        Takayoshi Watanabe; Ken-ichi Shinohara; Yoshinao Shinozaki; Syota Uekusa; Xiaofei Wang; Nobuko Koshikawa; Kiriko Hiraoka; Takahiro Inoue; Jason Lin; Toshikazu Bando; Hiroshi Sugiyama; Hiroki Nagase
        Advanced Techniques in Biology & Medicine, 2015
      • Single-Molecule Visualization of B–Z Transition in DNA Origami Using High-Speed AFM
        Masayuki Endo; Hiroshi Sugiyama
        Methods in Molecular Biology, 10 Mar. 2023
      • Substitution to hydrophobic linker and formation of host-guest complex enhanced the effect of synthetic transcription factor made of pyrrole-imidazole polyamide.
        Junnosuke Hatanaka; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Bioorganic & medicinal chemistry, 01 Mar. 2023, Peer-reviewed
      • Twelve Colors of Streptavidin-Fluorescent Proteins (SA-FPs): A Versatile Tool to Visualize Genetic Information in Single-Molecule DNA.
        Yu Jin; Jaeyoung Bae; Tehee Yurie Kim; Hyeseung Hwang; Taesoo Kim; Myungheon Yu; Hyesoo Oh; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Kyubong Jo
        Analytical chemistry, 06 Dec. 2022
      • N-terminal Cationic Modification of Linear Pyrrole-Imidazole Polyamide Improves Its Binding to DNA.
        Junnosuke Hatanaka; Yuki Hirose; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chembiochem : a European journal of chemical biology, 19 Jul. 2022
      • Author Correction: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.
        Etsuko Yamamoto Hattori; Tatsuya Masuda; Yohei Mineharu; Masamitsu Mikami; Yukinori Terada; Yasuzumi Matsui; Hirohito Kubota; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Shuji Ikeda; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo
        Communications biology, 27 Sep. 2022
      • A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.
        Etsuko Yamamoto Hattori; Tatsuya Masuda; Yohei Mineharu; Masamitsu Mikami; Yukinori Terada; Yasuzumi Matsui; Hirohito Kubota; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Shuji Ikeda; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo
        Communications biology, 09 Sep. 2022
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      • RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
        Sefan Asamitsu; Yasushi Yabuki; Kazuya Matsuo; Moe Kawasaki; Yuki Hirose; Gengo Kashiwazaki; Anandhakumar Chandran; Toshikazu Bando; Dan Ohtan Wang; Hiroshi Sugiyama; Norifumi Shioda
        Science advances, 24 Feb. 2023
      • Photocontrolled DNA nanotubes as stiffness tunable matrices for controlling cellular behavior
        Soumya Sethi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Nanoscale, 2023
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      • Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
        Mst. Ayesha Siddika; Takahiro Yamada; Risako Aoyama; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Molecules, 28 Nov. 2022
      • Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation.
        Yasuzumi Matsui; Yohei Mineharu; Yuki Noguchi; Etsuko Yamamoto Hattori; Hirohito Kubota; Masahiro Hirata; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo
        Biochemical and biophysical research communications, 10 Sep. 2022, Peer-reviewed
      • RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors.
        Masamitsu Mikami; Tatsuya Masuda; Takuya Kanatani; Mina Noura; Katsutsugu Umeda; Hidefumi Hiramatsu; Hirohito Kubota; Tomoo Daifu; Atsushi Iwai; Etsuko Yamamoto Hattori; Kana Furuichi; Saho Takasaki; Sunao Tanaka; Yasuzumi Matsui; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Yasumichi Kuwahara; Tomoko Iehara; Hajime Hosoi; Yoichi Imai; Junko Takita; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        Molecules and cells, 31 Dec. 2022
      • Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes
        Shankar Pandey; Sagun Jonchhe; Shubham Mishra; Tomoko Emura; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao
        The Journal of Physical Chemistry Letters, 12 Sep. 2022
      • Box-shaped ribozyme octamer formed by face-to-face dimerization of a pair of square-shaped ribozyme tetramers
        Md Dobirul Islam; Kumi Hidaka; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Journal of Bioscience and Bioengineering, Sep. 2022
      • RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia.
        Tatsuya Masuda; Shintaro Maeda; Sae Shimada; Naoya Sakuramoto; Ken Morita; Asami Koyama; Kensho Suzuki; Yoshihide Mitsuda; Hidemasa Matsuo; Hirohito Kubota; Itaru Kato; Kuniaki Tanaka; Junko Takita; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Souichi Adachi; Hideyo Hirai; Shuichi Mizuta; Kazuhito Naka; Yoichi Imai; Shinya Kimura; Hiroshi Sugiyama; Yasuhiko Kamikubo
        Cancer science, Feb. 2022, Peer-reviewed, Corresponding author
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      • 1PS042 Multiple kinesin molecules coordinate to ensure the long-distance walking : a DNA-kinesin hybrid nanomachine study(The 50th Annual Meeting of the Biophysical Society of Japan)
        Miyazono Yuya; Endo Masayuki; Ueda Takuya; Sugiyama Hiroshi; Harada Yoshie; Tadakuma Hisashi
        Seibutsu Butsuri, 2012
      • PD20 DNA STRAND SCISSION BY NEOCARZINOSTATIN : REACTION OF SELF-COMPLEMENTARY OLIGONUCLOETIDE
        Kawabata Hiroshi; Sugiyama Hiroshi; Takeshita Hiroshi; Matsuura Teruo; Saito Isao
        International Symposium on the Chemistry of Natural Products, 29 May 1988
      • Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
        Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Tatsuya Segawa; Jean-Pierre Bellier; Kumi Hidaka; Hiroshi Sugiyama; Daita Kaneda; Yoshio Hashizume; Hiroyasu Akatsu; Kunio Miki; Akiko Kita; Douglas G. Walker; Kazuhiro Irie; Ikuo Tooyama
        ACS Chemical Neuroscience, 31 Aug. 2021, Peer-reviewed
      • Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model
        Madhu Malinee; Ganesh Namasivayam Pandian; Hiroshi Sugiyama
        Cell Chemical Biology, Feb. 2022, Peer-reviewed
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      • SLD2 OXIDATIVE STRAND SCISSION OF DNA
        Matsuura Teruo; Saito Isao; Sugiyama Hiroshi; Morii Takashi
        International Symposium on the Chemistry of Natural Products, 29 May 1988
      • DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion
        Shengtao Yao; Yongyun Chang; Zanjing Zhai; Hiroshi Sugiyama; Masayuki Endo; Weiping Zhu; Yufang Xu; Yangyang Yang; Xuhong Qian
        ACS Appl. Mater. Interfaces, 29 Apr. 2022, Peer-reviewed
      • 1M1524 Constructing DNA-kinesin hybrid-nanomachine using the DNA-tile scaffold(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan)
        Miyazono Yuya; Endo Masayuki; Ueda Takuya; Sugiyama Hiroshi; Harada Yoshie; Tadakuma Hisashi
        Seibutsu Butsuri, 2011
      • An informatics approach to distinguish RNA modifications in nanopore direct RNA sequencing.
        Soundhar Ramasamy; Shubham Mishra; Surbhi Sharma; Sangamithirai Subramanian Parimalam; Thangavel Vaijayanthi; Yoto Fujita; Basavaraj Kovi; Hiroshi Sugiyama; Ganesh N Pandian
        Genomics, 20 Apr. 2022, Peer-reviewed
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      • Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses
        Soumya Sethi; Hiroshi Sugiyama; Masayuki Endo
        ChemBioChem, 18 Mar. 2022, Peer-reviewed
      • A Hexameric Ribozyme Nanostructure Formed by Double‐Decker Assembly of a Pair of Triangular Ribozyme Trimers
        Kai Yu; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        ChemBioChem, 18 Mar. 2022, Peer-reviewed
      • Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity
        Sagun Jonchhe; Shankar Pandey; Christian Beneze; Tomoko Emura; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao
        Nucleic Acids Research, 25 Jan. 2022, Peer-reviewed
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      • 2P-112 Examination of G-quadruplex Structures of Human Telomere DNA Based on the Single Molecule FRET Measurements with BrG-substitutions(The 46th Annual Meeting of the Biophysical Society of Japan)
        Okamoto Kenji; Sannohe Yuta; Mashimo Tomoko; Sugiyama Hiroshi; Terazima Masahide
        Seibutsu Butsuri, 2008
      • Strong and Specific Recognition of CAG/CTG Repeat DNA (5'-dWGCWGCW-3') by a Cyclic Pyrrole-Imidazole Polyamide.
        Yuki Hirose; Tomo Ohno; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chembiochem : a European journal of chemical biology, 19 Jan. 2022, Peer-reviewed
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      • Enhanced Immunostimulatory Activity of Covalent DNA Dendrons
        Yusuke Kawamoto; Wen Liu; Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura
        ChemBioChem, 08 Dec. 2021, Peer-reviewed
      • Comparative analysis of mitochondrial genomes in different species reveals the evolution of G-quadruplexes
        Hiroshi Sugiyama; Vinodh Sahayasheela; Zutao Yu; Ganesh Pandian
        01 Dec. 2021
      • Sequence-Specific Control of Using Programmable Synthetic Gene Switches Called MITO-PIPs
        Takuya Hidaka; Hiroshi Sugiyama; Ganesh N. Pandian
        Methods in Molecular Biology, 2021, Peer-reviewed
      • Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation
        Ganesh N. Pandian; Hiroshi Sugiyama
        Cell-Inspired Materials and Engineering, 2021
      • Photo-Controllable Phase Transition of Arylazopyrazole-Conjugated Oligonucleotides
        Takuya Hidaka; Wen Ann Wee; Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park
        Bioconjugate Chemistry, 20 Oct. 2021, Peer-reviewed
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      • Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs
        Satoru Ide; Asuka Sasaki; Yusuke Kawamoto; Toshikazu Bando; Hiroshi Sugiyama; Kazuhiro Maeshima
        Epigenetics & Chromatin, Dec. 2021, Peer-reviewed
      • Non‐invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polymer
        Soumya Sethi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Angewandte Chemie International Edition, 06 Sep. 2021, Peer-reviewed
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      • Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.
        Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama
        Cell chemical biology, 24 Feb. 2022, Peer-reviewed
      • RUNX inhibitor suppresses graft‐versus‐host disease through targeting RUNX‐NFATC2 axis
        Hirohito Kubota; Tatsuya Masuda; Mina Noura; Kana Furuichi; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R. Kataoka; Hidefumi Hiramatsu; Takahiro Yasumi; Tatsutoshi Nakahata; Yoichi Imai; Junko Takita; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo
        eJHaem, Aug. 2021, Peer-reviewed
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      • HBD1 protein with a tandem repeat of two HMG-box domains is a DNA clip to organize chloroplast nucleoids in Chlamydomonas reinhardtii
        Mari Takusagawa; Yusuke Kobayashi; Yoichiro Fukao; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Takashi Hamaji; Yoshinobu Kato; Isamu Miyakawa; Osami Misumi; Toshiharu Shikanai; Yoshiki Nishimura
        Proceedings of the National Academy of Sciences, 18 May 2021, Peer-reviewed
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      • Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways.
        Ming Wang; Xudong Ma; Kang Zhou; Huijuan Mao; Jiachun Liu; Xuqiong Xiong; Xiaoyin Zhao; Suresh Narva; Yoshimasa Tanaka; Yanling Wu; Chuanxin Guo; Hiroshi Sugiyama; Wen Zhang
        Journal of medicinal chemistry, 05 May 2021, Peer-reviewed
      • Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment.
        Rina Maeda; Toshikazu Bando; Hiroshi Sugiyama
        Chembiochem : a European journal of chemical biology, 04 May 2021, Peer-reviewed
      • Targeted epigenetic modulation using a DNA-based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells.
        Jin-A Lee; Jieun An; Junichi Taniguchi; Gengo Kashiwazaki; Ganesh N Pandian; Nazia Parveen; Tong Mook Kang; Hiroshi Sugiyama; Debojyoti De; Kyeong Kyu Kim
        Journal of cellular physiology, May 2021, Peer-reviewed
      • Flexible Assembly of Engineered Tetrahymena Ribozymes Forming Polygonal RNA Nanostructures with Catalytic Ability.
        Yuki Mori; Hiroki Oi; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Chembiochem : a European journal of chemical biology, 19 Apr. 2021, Peer-reviewed
      • Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin.
        Ji Hye Yum; Takumi Ishizuka; Koyuki Fukumoto; Daisuke Hori; Hong-Liang Bao; Yan Xu; Hiroshi Sugiyama; Soyoung Park
        ACS biomaterials science & engineering, 12 Apr. 2021, Peer-reviewed
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      • Landscape of immune cell infiltration in clear cell renal cell carcinoma to aid immunotherapy.
        Dan Bai; Huhu Feng; Jiajun Yang; Aiping Yin; Airong Qian; Hiroshi Sugiyama
        Cancer science, 18 Mar. 2021
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      • An RNA Triangle with Six Ribozyme Units Can Promote a Trans-Splicing Reaction through Trimerization of Unit Ribozyme Dimers
        Junya Akagi; Takahiro Yamada; Kumi Hidaka; Yoshihiko Fujita; Hirohide Saito; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Applied Sciences, 14 Mar. 2021
      • Nucleosomes and Epigenetics from a Chemical Perspective.
        Yihong Feng; Masayuki Endo; Hiroshi Sugiyama
        Chembiochem : a European journal of chemical biology, 15 Feb. 2021
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      • Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability.
        Bin Wang; Rizhao Pan; Weiping Zhu; Yufang Xu; Ye Tian; Masayuki Endo; Hiroshi Sugiyama; Yangyang Yang; Xuhong Qian
        Soft matter, 15 Feb. 2021
      • Nanoscopic observation of a DNA crystal surface and its dynamic formation and degradation using atomic force microscopy.
        Haruhiko Eki; Katsuhiko Abe; Hiroshi Sugiyama; Masayuki Endo
        Chemical communications (Cambridge, England), 14 Feb. 2021
      • Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole-Imidazole Polyamide.
        Yuki Hirose; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chemistry (Weinheim an der Bergstrasse, Germany), 05 Feb. 2021
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      • Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
        Tomoo Daifu; Masamitsu Mikami; Hidefumi Hiramatsu; Atsushi Iwai; Katsutsugu Umeda; Mina Noura; Hirohito Kubota; Tatsuya Masuda; Kana Furuichi; Saho Takasaki; Yuki Noguchi; Ken Morita; Toshikazu Bando; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Yasumichi Kuwahara; Tomoko Iehara; Hajime Hosoi; Junko Takita; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        Pediatric blood & cancer, Feb. 2021
      • Photocontrolled DNA Origami Assembly by Using Two Photoswitches.
        Shubham Mishra; Soyoung Park; Tomoko Emura; Hidaka Kumi; Hiroshi Sugiyama; Masayuki Endo
        Chemistry (Weinheim an der Bergstrasse, Germany), 07 Jan. 2021
      • Construction of an optically controllable CRISPR-Cas9 system using a DNA origami nanostructure
        Katsuhiko Abe; Hiroshi Sugiyama; Masayuki Endo
        Chemical Communications, 2021
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      • Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide.
        Yuki Araie; Shozo Ohtsuki; Soyoung Park; Makoto Nagaoka; Keisuke Umemura; Hiroshi Sugiyama; Kosuke Kusamori; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Bioorganic & medicinal chemistry, 01 Jan. 2021
      • CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.
        Sefan Asamitsu; Yasushi Yabuki; Susumu Ikenoshita; Kosuke Kawakubo; Moe Kawasaki; Shingo Usuki; Yuji Nakayama; Kaori Adachi; Hiroyuki Kugoh; Kazuhiro Ishii; Tohru Matsuura; Eiji Nanba; Hiroshi Sugiyama; Kohji Fukunaga; Norifumi Shioda
        Science advances, Jan. 2021
      • Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides.
        Takuya Hidaka; Hiroshi Sugiyama
        Chemical record (New York, N.Y.), 17 Dec. 2020
      • Design, synthesis and anti-cancer activity of pyrrole-imidazole polyamides through target-downregulation of c-kit gene expression.
        Mi Zhang; Jing Liang; Shi-Kun Jiang; Ling Xu; Yan-Ling Wu; Annoor Awadasseid; Xiao-Yin Zhao; Xu-Qiong Xiong; Hiroshi Sugiyama; Wen Zhang
        European journal of medicinal chemistry, 01 Dec. 2020
      • Direct Observation of Dynamic Interactions between Orientation-Controlled Nucleosomes in a DNA Origami Frame.
        Yihong Feng; Fumitaka Hashiya; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Chemistry (Weinheim an der Bergstrasse, Germany), 26 Nov. 2020
      • DNA Alkylation of the RUNX-Binding Sequence by CBI-PI Polyamide Conjugates*.
        Rina Maeda; Shinji Ito; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chemistry (Weinheim an der Bergstrasse, Germany), 17 Nov. 2020, Peer-reviewed
      • Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
        Nor Amira Khurshid Ahmed; Shern Kwok Lim; Ganesh N Pandian; Hiroshi Sugiyama; Chong Yew Lee; Boon Yin Khoo; Kit Lam Chan
        Molecular medicine reports, Nov. 2020
      • Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector.
        Takuya Hidaka; Yutaro Tsubono; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama
        Chemical communications (Cambridge, England), 21 Oct. 2020
      • Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide.
        Yan Shan Ang; Toshikazu Bando; Hiroshi Sugiyama; Lin-Yue Lanry Yung
        Chembiochem : a European journal of chemical biology, 15 Oct. 2020, Peer-reviewed
      • A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres.
        Yutaro Tsubono; Yusuke Kawamoto; Takuya Hidaka; Ganesh N Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Journal of the American Chemical Society, 14 Oct. 2020
      • Construction of a FRET System in a Double-Stranded DNA Using Fluorescent Thymidine and Cytidine Analogs.
        Shingo Hirashima; Hiroshi Sugiyama; Soyoung Park
        The journal of physical chemistry. B, 08 Oct. 2020
      • Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions.
        Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park
        Organic & biomolecular chemistry, 21 Sep. 2020
      • Catalytic RNA nano-objects formed by self-assembly of group I ribozyme dimers serving as unit structures.
        Ryuji Kiyooka; Junya Akagi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Journal of bioscience and bioengineering, Sep. 2020, Peer-reviewed
      • DNA Nanostructures for Targeted Antimicrobial Delivery.
        Ioanna Mela; Pedro P Vallejo-Ramirez; Stanislaw Makarchuk; Graham Christie; David Bailey; Robert M Henderson; Hiroshi Sugiyama; Masayuki Endo; Clemens F Kaminski
        Angewandte Chemie (International ed. in English), 27 Jul. 2020, Peer-reviewed
      • DNA Nanostructures for Targeted Antimicrobial Delivery
        Ioanna Mela; Pedro P. Vallejo-Ramirez; Stanislaw Makarchuk; Graham Christie; David Bailey; Robert M. Henderson; Hiroshi Sugiyama; Masayuki Endo; Clemens F. Kaminski
        Angewandte Chemie, 27 Jul. 2020, Peer-reviewed
      • DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells.
        Tatsuoki Maezawa; Shozo Ohtsuki; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Nanoscale, 16 Jul. 2020, Peer-reviewed
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      • Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles.
        Tomohiro Nobeyama; Kazuki Shigyou; Hirotaka Nakatsuji; Hiroshi Sugiyama; Naoko Komura; Hiromune Ando; Tsutomu Hamada; Tatsuya Murakami
        Langmuir : the ACS journal of surfaces and colloids, 07 Jul. 2020, Peer-reviewed
      • Development of Antibody-Oligonucleotide Complexes for Targeting Exosomal MicroRNA.
        Asako Yamayoshi; Shota Oyama; Yusuke Kishimoto; Ryo Konishi; Tsuyoshi Yamamoto; Akio Kobori; Hiroshi Harada; Eishi Ashihara; Hiroshi Sugiyama; Akira Murakami
        Pharmaceutics, 12 Jun. 2020, Peer-reviewed
      • X-ray Crystal Structure of a Cyclic-PIP-DNA Complex in the Reverse-Binding Orientation.
        Katsuhiko Abe; Yuki Hirose; Haruhiko Eki; Kazuki Takeda; Toshikazu Bando; Masayuki Endo; Hiroshi Sugiyama
        Journal of the American Chemical Society, 10 Jun. 2020, Peer-reviewed
      • Duplex DNA Is Weakened in Nanoconfinement.
        Sagun Jonchhe; Shankar Pandey; Deepak Karna; Pravin Pokhrel; Yunxi Cui; Shubham Mishra; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao
        Journal of the American Chemical Society, 03 Jun. 2020, Peer-reviewed
      • Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications
        Soundhar Ramasamy; Vinodh J Sahayasheela; Zutao Yu; Takuya Hidaka; Li Cai; Hiroshi Sugiyama; Ganesh N. Pandian
        20 May 2020
      • Direct observation and analysis of TET-mediated oxidation processes in a DNA origami nanochip.
        Xiwen Xing; Shinsuke Sato; Nai-Kei Wong; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Nucleic acids research, 07 May 2020, Peer-reviewed
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      • N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.
        Callum J C Parr; Shunsuke Wada; Kenjiro Kotake; Shigetoshi Kameda; Satoshi Matsuura; Souhei Sakashita; Soyoung Park; Hiroshi Sugiyama; Yi Kuang; Hirohide Saito
        Nucleic acids research, 06 Apr. 2020, Peer-reviewed
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      • A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.
        Zutao Yu; Mengting Ai; Soumen K Samanta; Fumitaka Hashiya; Junichi Taniguchi; Sefan Asamitsu; Shuji Ikeda; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Lyle Isaacs; Hiroshi Sugiyama
        Chemical communications (Cambridge, England), 28 Jan. 2020, Peer-reviewed
      • Advances in DNA Origami–Cell Interfaces
        Shubham Mishra; Yihong Feng; Masayuki Endo; Hiroshi Sugiyama
        ChemBioChem, 15 Jan. 2020, Peer-reviewed
      • A photocaged DNA nanocapsule for delivery and manipulation in cells.
        Yihong Feng; Takeshi Tohgasaki; Yasuyuki Shitomi; Hiroshi Sugiyama; Masayuki Endo
        Methods in enzymology, 2020, Peer-reviewed
      • Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake.
        Shozo Ohtsuki; Yukako Shiba; Tatsuoki Maezawa; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Nanoscale, 28 Dec. 2019, Peer-reviewed
      • Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillization.
        Ryu Tashiro; Hiroaki Taguchi; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama
        Chemistry, an Asian journal, 02 Dec. 2019, Peer-reviewed
      • Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide.
        Malinee M; Kumar A; Hidaka T; Horie M; Hasegawa K; Pandian GN; Sugiyama H
        Bioorganic & medicinal chemistry, Dec. 2019, Peer-reviewed
      • G-quadruplexes as versatile scaffolds for catalysis.
        Yum JH; Park S; Sugiyama H
        Organic & biomolecular chemistry, Nov. 2019, Peer-reviewed
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      • Oligomerization of a modular ribozyme assembly of which is controlled by a programmable RNA–RNA interface between two structural modules
        Ryusei Tsuruga; Narumi Uehara; Yuki Suzuki; Hiroyuki Furuta; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        Journal of Bioscience and Bioengineering, Oct. 2019, Peer-reviewed
      • Highly sensitive and selective mercury sensor based on mismatched base pairing with dioxT.
        Han JH; Hirashima S; Park S; Sugiyama H
        Chemical communications (Cambridge, England), Aug. 2019, Peer-reviewed
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      • Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole-Imidazole Polyamides.
        Hirose Y; Asamitsu S; Bando T; Sugiyama H
        Journal of the American Chemical Society, Aug. 2019, Peer-reviewed
      • Switching Off Cancer-Causing Telomerase Using Small Molecules.
        Asamitsu S; Shioda N; Sugiyama H
        Cell chemical biology, Aug. 2019, Peer-reviewed
      • Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
        Takashi Mino; Noriki Iwai; Masayuki Endo; Kentaro Inoue; Kotaro Akaki; Fabian Hia; Takuya Uehata; Tomoko Emura; Kumi Hidaka; Yutaka Suzuki; Daron M Standley; Mariko Okada-Hatakeyama; Shigeo Ohno; Hiroshi Sugiyama; Akio Yamashita; Osamu Takeuchi
        Nucleic Acids Research, 22 Jul. 2019, Peer-reviewed
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      • A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell
        Takeshi Tohgasaki; Yasuyuki Shitomi; Yihong Feng; Saisei Honna; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Bioconjugate Chemistry, 17 Jul. 2019, Peer-reviewed
      • Direct Observation and Analysis of the Dynamics of the Photoresponsive Transcription Factor GAL4
        Guruprasad Raghavan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        Angewandte Chemie International Edition, 03 Jun. 2019, Peer-reviewed
      • Orientation preferences of hairpin pyrrole-imidazole polyamides toward mCGG site.
        Sato S; Asamitsu S; Bando T; Sugiyama H
        Bioorganic & medicinal chemistry, Jun. 2019, Peer-reviewed
      • New Size-expanded Fluorescent Thymine Analogue: Synthesis, Characterization, and Application.
        Hiroshima S; Han JH; Tsuno H; Tanigaki Y; Park S; Sugiyama H
        Chemistry (Weinheim an der Bergstrasse, Germany), May 2019, Peer-reviewed
      • Programming Rotary Motions with a Hexagonal DNA Nanomachine
        Yangyang Yang; Shiwei Zhang; Shengtao Yao; Rizhao Pan; Kumi Hidaka; Tomoko Emura; Chunhai Fan; Hiroshi Sugiyama; Yufang Xu; Masayuki Endo; Xuhong Qian
        Chemistry – A European Journal, 05 Apr. 2019, Peer-reviewed
      • Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface.
        Mandal S; Kawamoto Y; Yue Z; Hashiya K; Cui Y; Bando T; Pandey S; Hoque ME; Hossain MA; Sugiyama H; Mao H
        Nucleic acids research, Mar. 2019, Peer-reviewed
      • Therapeutic gene regulation using pyrrole-imidazole polyamides.
        Yu Z; Pandian GN; Hidaka T; Sugiyama H
        Advanced drug delivery reviews, Feb. 2019, Peer-reviewed
      • Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones.
        Yum JH; Park S; Hiraga R; Okamura I; Notsu S; Sugiyama H
        Organic & biomolecular chemistry, Feb. 2019, Peer-reviewed
      • Direct Observation of the Double-Stranded DNA Formation through Metal Ion-Mediated Base Pairing in the Nanoscale Structure
        Xiwen Xing; Yihong Feng; Zutao Yu; Kumi Hidaka; Fenyong Liu; Akira Ono; Hiroshi Sugiyama; Masayuki Endo
        Chemistry - A European Journal, 28 Jan. 2019, Peer-reviewed
      • Direct observation of dynamic movement of DNA molecules in DNA origami imaged using high-speed AFM
        M. Endo; X. Xing; H. Sugiyama
        Methods in Molecular Biology, 2019, Peer-reviewed, Invited
      • 脂質膜表面におけるDNAオリガミの二次元自己集合化
        鈴木 勇揮; 遠藤 政幸; 杉山 弘
        生物物理, 2019, Peer-reviewed, Invited
      • Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM
        Masayuki Endo; Xiwen Xing; Hiroshi Sugiyama
        Methods in Molecular Biology, 2019, Peer-reviewed
      • Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy.
        Asamitsu S; Obata S; Yu Z; Bando T; Sugiyama H
        Molecules (Basel, Switzerland), Jan. 2019, Peer-reviewed
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      • Molecular characteristics of DNA-alkylating PI polyamides targeting RUNX transcription factors.
        Maeda R; Sato S; Ohno T; Kashiwazaki G; Obata S; Hashiya K; Bando T; Sugiyama H
        Journal of the American Chemical Society, Jan. 2019, Peer-reviewed
      • RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells
        Yoshihide Mitsuda; Ken Morita; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Moeka Obara; Masahiro Hirata; Tatsuki R. Kataoka; Manabu Muto; Yasufumi Kaneda; Tatsutoshi Nakahata; Pu Paul Liu; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo
        Scientific Reports, 01 Dec. 2018, Peer-reviewed
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      • Chemical Control System of Epigenetics.
        Vaijayanthi T; Pandian GN; Sugiyama H
        Chemical record (New York, N.Y.), Dec. 2018, Peer-reviewed
      • Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-Quadruplex.
        Jonchhe S; Ghimire C; Cui Y; Sasaki S; McCool M; Park S; Iida K; Nagasawa K; Sugiyama H; Mao H
        Angewandte Chemie (International ed. in English), Nov. 2018, Peer-reviewed
      • Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.
        Hashiya F; Ito S; Sugiyama H
        Bioorganic & medicinal chemistry, Nov. 2018, Peer-reviewed
      • Construction of integrated gene logic-chip
        Takeya Masubuchi; Masayuki Endo; Ryo Iizuka; Ayaka Iguchi; Dong Hyun Yoon; Tetsushi Sekiguchi; Hao Qi; Ryosuke Iinuma; Yuya Miyazono; Shuichi Shoji; Takashi Funatsu; Hiroshi Sugiyama; Yoshie Harada; Takuya Ueda; Hisashi Tadakuma
        Nature Nanotechnology, 01 Oct. 2018, Peer-reviewed
      • Decreased water activity in nanoconfinement contributes to the folding of G-quadruplex and i-motif structures
        Sagun Jonchhe; Shankar Pandey; Tomoko Emura; Kumi Hidaka; Mohammad Akter Hossain; Prakash Shrestha; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao
        Proceedings of the National Academy of Sciences, 18 Sep. 2018, Peer-reviewed
      • Novel Approach to the Investigation of Nucleosome Structure Using the Highly Emissive Nucleobase thdG-tC FRET Pair.
        Han JH; Park S; Hashiya F; Sugiyama H
        Chemistry (Weinheim an der Bergstrasse, Germany), Sep. 2018, Peer-reviewed
      • Sequence preference and structural heterogeneity of BZ junctions.
        Kim D; Hur J; Han JH; Ha SC; Shin D; Lee S; Park S; Sugiyama H; Kim KK
        Nucleic acids research, Sep. 2018, Peer-reviewed
      • Direct observation of H3-H4 octasome by high-speed AFM.
        Zou T; Hashiya F; Wei Y; Pandian GN; Sugiyama H
        Chemistry (Weinheim an der Bergstrasse, Germany), Aug. 2018, Peer-reviewed
      • DNA Origami Nanomachines
        Masayuki Endo; Hiroshi Sugiyama
        Molecules, 18 Jul. 2018, Peer-reviewed
      • Colloidal stability of lipid/protein-coated nanomaterials in salt and sucrose solutions.
        T. Nobeyama; M. Mori; K. Shiyou; Ganesh N. Pandian; H. Sugiyama; T. Murakami
        ChemistrySelect, Jul. 2018, Peer-reviewed
      • Environment-Dependent Self-Assembly of DNA Origami Lattices on Phase-Separated Lipid Membranes
        Yusuke Sato; Masayuki Endo; Masamune Morita; Masahiro Takinoue; Hiroshi Sugiyama; Satoshi Murata; Shin-ichiro M. Nomura; Yuki Suzuki
        Advanced Materials Interfaces, Jul. 2018, Peer-reviewed
      • Orthogonal γPNA dimerization domains empower DNA binders with cooperativity and versatility mimicking that of transcription factor pairs.
        Yu Z; Hsieh WC; Asamitsu S; Hashiya K; Bando T; Ly DH; Sugiyama H
        Chemistry (Weinheim an der Bergstrasse, Germany), Jul. 2018, Peer-reviewed
      • Ligand design to acquire specificity to intended G-quadruplex structures.
        Asamitsu S; Bando T; Sugiyama H
        Chemistry (Weinheim an der Bergstrasse, Germany), Jul. 2018, Peer-reviewed
      • Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones
        Junichi Taniguchi; Yihong Feng; Ganesh N. Pandian; Fumitaka Hashiya; Takuya Hidaka; Kaori Hashiya; Soyoung Park; Toshikazu Bando; Shinji Ito; Hiroshi Sugiyama
        Journal of the American Chemical Society, 13 Jun. 2018, Peer-reviewed
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      • Complexing DNA Origami Frameworks through Sequential Self-Assembly Based on Directed Docking.
        Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo
        Angewandte Chemie (International ed. in English), 11 Jun. 2018, Peer-reviewed
      • TAMRA-polypyrrole for A/T sequence visualization on DNA molecules.
        Lee S; Kawamoto Y; Vaijayanthi T; Park J; Bae J; Kim-Ha J; Sugiyama H; Jo K
        Nucleic acids research, Jun. 2018, Peer-reviewed
      • Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome article
        Norifumi Shioda; Yasushi Yabuki; Kouya Yamaguchi; Misaki Onozato; Yue Li; Kenji Kurosawa; Hideyuki Tanabe; Nobuhiko Okamoto; Takumi Era; Hiroshi Sugiyama; Takahito Wada; Kohji Fukunaga
        Nature Medicine, 01 Jun. 2018, Peer-reviewed
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      • Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
        Yusuke Kawamoto; Toshikazu Bando; Hiroshi Sugiyama
        Bioorganic and Medicinal Chemistry, 01 May 2018, Peer-reviewed
      • Investigating Nucleosome Accessibility for MNase, FeII Peplomycin, and Duocarmycin B2 by Using Capillary Electrophoresis
        Tingting Zou; Seiichiro Kizaki; Hiroshi Sugiyama
        ChemBioChem, 04 Apr. 2018, Peer-reviewed
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      • Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex
        Sefan Asamitsu; Shunsuke Obata; Anh Tuân Phan; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Chemistry - A European Journal, 20 Mar. 2018, Peer-reviewed
      • DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels.
        Tatsuki Kurokawa; Shigeki Kiyonaka; Eiji Nakata; Masayuki Endo; Shohei Koyama; Emiko Mori; Nam Ha Tran; Huyen Dinh; Yuki Suzuki; Kumi Hidaka; Masaaki Kawata; Chikara Sato; Hiroshi Sugiyama; Takashi Morii; Yasuo Mori
        Angewandte Chemie (International ed. in English), 01 Mar. 2018, Peer-reviewed
      • RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice.
        Morita K; Tokushige C; Maeda S; Kiyose H; Noura M; Iwai A; Yamada M; Kashiwazaki G; Taniguchi J; Bando T; Hirata M; Kataoka TR; Nakahata T; Adachi S; Sugiyama H; Kamikubo Y
        Blood advances, Mar. 2018, Peer-reviewed
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      • Pip-HoGu: An Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs
        Zutao Yu; Chuanxin Guo; Yulei Wei; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Journal of the American Chemical Society, 21 Feb. 2018, Peer-reviewed
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      • Triggering nucleic acid nanostructure assembly by conditional kissing interactions
        Laurent Azéma; Servane Bonnet-Salomon; Masayuki Endo; Yosuke Takeuchi; Guillaume Durand; Tomoko Emura; Kumi Hidaka; Eric Dausse; Hiroshi Sugiyama; Jean-Jacques Toulmé
        Nucleic Acids Research, 16 Feb. 2018, Peer-reviewed
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      • G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer
        Shunsuke Obata; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Biochemistry, 06 Feb. 2018, Peer-reviewed
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      • Direct Observation of Dynamic Movement of DNA Molecules in DNA Origami Imaged Using High-Speed AFM
        Masayuki Endo; Hiroshi Sugiyama
        Methods in Molecular Biology, 2018, Peer-reviewed
      • Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
        Yulei Wei; Ganesh N. Pandian; Zutao Yu; Tingting Zou; Yue Li; Jayant Darokar; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        ACS Omega, 2018, Peer-reviewed
      • UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258
        Abhijit Saha; Seiichiro Kizaki; Ji Hoon Han; Zutao Yu; Hiroshi Sugiyama
        Bioorganic and Medicinal Chemistry, 01 Jan. 2018, Peer-reviewed
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      • Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer
        Gengo Kashiwazaki; Rina Maeda; Takashi Kawase; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Bioorganic and Medicinal Chemistry, 01 Jan. 2018, Peer-reviewed
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      • DNA配列認識副溝結合物質(MGB)を応用した生体内のゲノム・エピゲノム構造介入 ピロールイミダゾールポリアミドによるクロマチン構造とダイナミクスの機能解析
        井手 聖; 佐々木 飛鳥; 河本 佑介; 板東 俊和; 杉山 弘; 岡田 康志; 前島 一博
        生命科学系学会合同年次大会, Dec. 2017, Peer-reviewed
      • A Combination of Visible-light Photoredox and Metal Catalysis for the Mannich-type Reaction of N-Aryl Glycine Esters
        Izumi Okamura; Soyoung Park; Ji Hoon Han; Shunta Notsu; Hiroshi Sugiyama
        CHEMISTRY LETTERS, Nov. 2017, Peer-reviewed
      • Single-Molecule Observation of the Photoregulated Conformational Dynamics of DNA Origami Nanoscissors
        Elena M. Willner; Yuu Kamada; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Hendrik Dietz; Hiroshi Sugiyama; Masayuki Endo
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Nov. 2017, Peer-reviewed
      • Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells
        Ken Morita; Mina Noura; Chieko Tokushige; Shintaro Maeda; Hiroki Kiyose; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Kenichi Yoshida; Toshifumi Ozaki; Hidemasa Matsuo; Seishi Ogawa; Pu Paul Liu; Tatsutoshi Nakahata; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        SCIENTIFIC REPORTS, Nov. 2017, Peer-reviewed
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      • Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex
        Jumpei Ariyoshi; Yohei Matsuyama; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi
        NUCLEIC ACID THERAPEUTICS, Oct. 2017, Peer-reviewed
      • Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors
        Zutao Yu; Junichi Taniguchi; Yulei Wei; Ganesh N. Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, Sep. 2017, Peer-reviewed
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      • Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate
        Tomonori Shibata; Yoshihiko Fujita; Hirohisa Ohno; Yuki Suzuki; Karin Hayashi; Kaoru R. Komatsu; Shunsuke Kawasaki; Kumi Hidaka; Shin Yonehara; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito
        NATURE COMMUNICATIONS, Sep. 2017, Peer-reviewed
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      • A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm
        Junichi Taniguchi; Ganesh N. Pandian; Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Kyeong Kyu Kim; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Sep. 2017, Peer-reviewed
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      • Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction
        Sohei Sakashita; Soyoung Park; Hiroshi Sugiyama
        CHEMISTRY LETTERS, Aug. 2017
      • Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions.
        Morita K; Maeda S; Suzuki K; Kiyose H; Taniguchi J; Liu PP; Sugiyama H; Adachi S; Kamikubo Y
        Blood advances, Aug. 2017, Peer-reviewed
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      • WITHDRAWN: Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer.
        Kashiwazaki G; Maeda R; Kawase T; Hashiya K; Bando T; Sugiyama H
        Bioorganic & medicinal chemistry, Jul. 2017, Peer-reviewed
      • Confined space facilitates G-quadruplex formation
        Prakash Shrestha; Sagun Jonchhe; Tomoko Emura; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao
        NATURE NANOTECHNOLOGY, Jun. 2017, Peer-reviewed
      • Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair
        Ji Hoon Han; Seigi Yamamoto; Soyoung Park; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2017, Peer-reviewed
      • Genetic regulation of the RUNX transcription factor family has antitumor effects
        Ken Morita; Kensho Suzuki; Shintaro Maeda; Akihiko Matsuo; Yoshihide Mitsuda; Chieko Tokushige; Gengo Kashiwazaki; Junichi Taniguchi; Rina Maeda; Mina Noura; Masahiro Hirata; Tatsuki Kataoka; Ayaka Yano; Yoshimi Yamada; Hiroki Kiyose; Mayu Tokumasu; Hidemasa Matsuo; Sunao Tanaka; Yasushi Okuno; Manabu Muto; Kazuhito Naka; Kosei Ito; Toshio Kitamura; Yasufumi Kaneda; Paul P. Liu; Toshikazu Bando; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo
        JOURNAL OF CLINICAL INVESTIGATION, Jun. 2017, Peer-reviewed
      • Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression
        Takuya Hidaka; Ganesh N. Pandian; Junichi Taniguchi; Tomohiro Nobeyama; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2017, Peer-reviewed
      • Programmable formation of catalytic RNA triangles and squares by assembling modular RNA enzymes
        Hiroki Oi; Daisuke Fujita; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa
        JOURNAL OF BIOCHEMISTRY, May 2017, Peer-reviewed
      • Holliday junction resolvases mediate chloroplast nucleoid segregation
        Yusuke Kobayashi; Osami Misumi; Masaki Odahara; Kota Ishibashi; Masafumi Hirono; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Hiroshi Iwasaki; Tsuneyoshi Kuroiwa; Toshiharu Shikanai; Yoshiki Nishimura
        SCIENCE, May 2017, Peer-reviewed
      • A Photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement
        Yangyang Yang; Ryu Tashiro; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        CHEMISTRY-A EUROPEAN JOURNAL, Mar. 2017, Peer-reviewed
      • Synthesis, Photophysical Properties, and Enzymatic Incorporation of an Emissive Thymidine Analogue
        Izumi Okamura; Soyoung Park; Ryota Hiraga; Seigi Yamamoto; Hiroshi Sugiyama
        CHEMISTRY LETTERS, Feb. 2017, Peer-reviewed
      • The chemical compound bubblin induces stomatal mispatterning in Arabidopsis by disrupting the intrinsic polarity of stomatal lineage cells
        Yumiko Sakai; Shigeo S. Sugano; Takashi Kawase; Makoto Shirakawa; Yu Imai; Yusuke Kawamoto; Hiroshi Sugiyama; Tsuyoshi Nakagawa; Ikuko Hara-Nishimura; Tomoo Shimada
        DEVELOPMENT, Feb. 2017, Peer-reviewed
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      • Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads
        Chao-Da Xiao; Takumi Ishizuka; Xiao-Qing Zhu; Yue Li; Hiroshi Sugiyama; Yan Xu
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2017, Peer-reviewed
      • Characterization of the releasing profile of microRNA from RISC using anti-miRNA oligonucleotides
        Jumpei Ariyoshi; Nao Eimori; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi
        Chemistry Letters, 2017, Peer-reviewed
      • DNA分子マシン
        遠藤 政幸; 杉山 弘
        日本化学会編『CSJカレントレビュー 分子マシンの展開』, 2017, Peer-reviewed
      • DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates
        Chuanxin Guo; Sefan Asamitsu; Gengo Kashiwazaki; Shinsuke Sato; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Jan. 2017, Peer-reviewed
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      • A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes
        Yulei Wei; Ganesh N. Pandian; Tingting Zou; Junichi Taniguchi; Shinsuke Sato; Gengo Kashiwazaki; Thangavel Vaijayanthi; Takuya Hidaka; Toshikazu Bando; Hiroshi Sugiyama
        CHEMISTRYOPEN, Dec. 2016, Peer-reviewed
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      • RNA-DNA Triplex Formation by Long Noncoding RNAs
        Yue Li; Junetha Syed; Hiroshi Sugiyama
        Cell Chemical Biology, 17 Nov. 2016, Peer-reviewed
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      • Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein
        Seiichiro Kizaki; Tingting Zou; Yue Li; Yong-Woon Han; Yuki Suzuki; Yoshie Harada; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Nov. 2016, Peer-reviewed
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      • Similarities and Differences between RNA and DNA Double-Helical Structures in Circular Dichroism Spectroscopy: A SAC-CI Study
        Tomoo Miyahara; Hiroshi Nakatsuji; Hiroshi Sugiyama
        JOURNAL OF PHYSICAL CHEMISTRY A, Nov. 2016, Peer-reviewed
      • Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole-Imidazole Polyamide Probes
        Yusuke Kawamoto; Asuka Sasaki; Anandhakumar Chandran; Kaori Hashiya; Satoru Ide; Toshikazu Bando; Kazuhiro Maeshima; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2016, Peer-reviewed
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      • Torsional Constraints of DNA Substrates Impact Cas9 Cleavage
        Michael H. Raz; Kumi Hidaka; Shana J. Sturla; Hiroshi Sugiyama; Masayuki Endo
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2016, Peer-reviewed
      • Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by High-Throughput Sequencing
        Anandhakumar Chandran; Junetha Syed; Yue Li; Shinsuke Sato; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Oct. 2016, Peer-reviewed
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      • Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome
        Jason Lin; Kiriko Hiraoka; Takayoshi Watanabe; Tony Kuo; Yoshinao Shinozaki; Atsushi Takatori; Nobuko Koshikawa; Anandhakumar Chandran; Joe Otsuki; Hiroshi Sugiyama; Paul Horton; Hiroki Nagase
        PLOS ONE, Oct. 2016, Peer-reviewed
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      • Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing
        Gengo Kashiwazaki; Anandhakumar Chandran; Sefan Asamitsu; Takashi Kawase; Yusuke Kawamoto; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Sep. 2016, Peer-reviewed
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      • Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids
        Ganesh N. Pandian; Hiroshi Sugiyama
        BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Aug. 2016, Peer-reviewed
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      • Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay
        Abhijit Saha; Seiichiro Kizaki; Debojyoti De; Masayuki Endo; Kyeong Kyu Kim; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Aug. 2016, Peer-reviewed
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      • Sequence-specific DNA binding by long hairpin pyrrole-imidazole polyamides containing an 8-amino-3,6-dioxaoctanoic acid unit
        Yoshito Sawatani; Gengo Kashiwazaki; Anandhakumar Chandran; Sefan Asamitsu; Chuanxin Guo; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2016, Peer-reviewed
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      • Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores
        Prakash Shrestha; Tomoko Emura; Deepak Koirala; Yunxi Cui; Kumi Hidaka; William J. Maximuck; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao
        NUCLEIC ACIDS RESEARCH, Aug. 2016, Peer-reviewed
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      • Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide
        Sefan Asamitsu; Yue Li; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Jul. 2016, Peer-reviewed
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      • Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes
        Asuka Sasaki; Satoru Ide; Yusuke Kawamoto; Toshikazu Bando; Yukinori Murata; Mari Shimura; Kazuhiko Yamada; Akiyoshi Hirata; Kiyoshi Nokihara; Tatsumi Hirata; Hiroshi Sugiyama; Kazuhiro Maeshima
        SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed
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      • A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA
        Yousuke Katsuda; Shin-ichi Sato; Lisa Asano; Yoshitaka Morimura; Tomoyuki Furuta; Hiroshi Sugiyama; Masaki Hagihara; Motonari Uesugi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2016, Peer-reviewed
      • Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B-2 to Duplex DNA
        Tingting Zou; Seiichiro Kizaki; Ganesh N. Pandian; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2016, Peer-reviewed
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      • Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on alpha-Globin Gene Expression
        Yue Li; Junetha Syed; Yuki Suzuki; Sefan Asamitsu; Norifumi Shioda; Takahito Wada; Hiroshi Sugiyama
        CHEMBIOCHEM, May 2016, Peer-reviewed
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      • Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing
        Anandhakumar Chandran; Junetha Syed; Rhys D. Taylor; Gengo Kashiwazaki; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, May 2016, Peer-reviewed
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      • Triple Helix Formation in a Topologically Controlled DNA Nanosystem
        Yutaro Yamagata; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo
        CHEMISTRY-A EUROPEAN JOURNAL, Apr. 2016, Peer-reviewed
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      • Identification of Sequence Specificity of 5-Methylcytosine Oxidation by Tet1 Protein with High-Throughput Sequencing
        Seiichiro Kizaki; Anandhakumar Chandran; Hiroshi Sugiyama
        CHEMBIOCHEM, Mar. 2016, Peer-reviewed
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      • A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function
        Anton Kuzyk; Yangyang Yang; Xiaoyang Duan; Simon Stoll; Alexander O. Govorov; Hiroshi Sugiyama; Masayuki Endo; Na Liu
        NATURE COMMUNICATIONS, Feb. 2016, Peer-reviewed
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      • Single-molecule observations of RNA-RNA kissing interactions in a DNA nanostructure
        Yosuke Takeuchi; Masayuki Endo; Yuki Suzuki; Kumi Hidaka; Guillaume Durand; Eric Dausse; Jean-Jacques Toulme; Hiroshi Sugiyama
        BIOMATERIALS SCIENCE, 2016, Peer-reviewed
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      • The application of fluorescence-conjugated pyrrole/imidazole polyamides in the characterization of protein-DNA complex formation
        Yong-Woon Han; Hiroshi Sugiyama; Yoshie Harada
        BIOMATERIALS SCIENCE, 2016, Peer-reviewed
      • Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion (vol 5, 14979, 2015)
        Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa
        SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed
      • Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells
        Yu Nishida; Shozo Ohtsuki; Yuki Araie; Yuka Umeki; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Jan. 2016, Peer-reviewed
      • Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA
        Tomoki Shiomi; Mengmeng Tan; Natsuki Takahashi; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        NANO RESEARCH, Dec. 2015, Peer-reviewed
      • Water revealed as molecular mirror when measuring low concentrations of sugar with near infrared light
        György Bázár; Zoltan Kovacs; Mariko Tanaka; Akane Furukawa; Airi Nagai; Manami Osawa; Yukari Itakura; Hiroshi Sugiyama; Roumiana Tsenkova
        Analytica Chimica Acta, 08 Oct. 2015, Peer-reviewed
      • Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion
        Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa
        SCIENTIFIC REPORTS, Oct. 2015, Peer-reviewed
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      • Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells
        Shozo Ohtsuki; Noriyuki Matsuzaki; Kohta Mohri; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Kenichi Ishiyama; Norimitsu Kadowaki; Yoshinobu Takakura; Makiya Nishikawa
        NUCLEIC ACID THERAPEUTICS, Oct. 2015, Peer-reviewed
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      • Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression
        Sahishnu Patel; Sy-Tsong Dean Chueng; Perry T. Yin; Kholud Dardir; Zhichao Song; Nicholas Pasquale; Kelvin Kwan; Hiroshi Sugiyama; Ki-Bum Lee
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Oct. 2015, Peer-reviewed
      • Direct Visualization of Walking Motions of Photocontrolled Nanomachine on the DNA Nanostructure
        Yangyang Yang; Marisa A. Goetzfried; Kumi Hidaka; Mingxu You; Weihong Tan; Hiroshi Sugiyama; Masayuki Endo
        NANO LETTERS, Oct. 2015, Peer-reviewed
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      • Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates
        Rhys D. Taylor; Anandhakumar Chandran; Gengo Kashiwazaki; Kaori Hashiya; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Oct. 2015, Peer-reviewed
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      • Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure
        Masayuki Endo; Xiwen Xing; Xiang Zhou; Tomoko Emura; Kumi Hidaka; Bodin Tuesuwan; Hiroshi Sugiyama
        ACS NANO, Oct. 2015, Peer-reviewed
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      • Studying RNAP-promoter interactions using atomic force microscopy
        Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama
        METHODS, Sep. 2015, Peer-reviewed
      • Single-Molecule Visualization of the Activity of a Zn2+-Dependent DNAzyme
        Masayuki Endo; Yosuke Takeuchi; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Fuan Wang; Itamar Willner; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2015, Peer-reviewed
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      • Development of DNA Metalloenzymes Using a Rational Design Approach and Application in the Asymmetric Diels-Alder Reaction
        Soyoung Park; Izumi Okamura; Sohei Sakashita; Ji Hye Yum; Chiranjit Acharya; Li Gao; Hiroshi Sugiyama
        ACS CATALYSIS, Aug. 2015, Peer-reviewed
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      • Linking two DNA duplexes with a rigid linker for DNA nanotechnology
        Ryu Tashiro; Masahiro Iwamoto; Hironobu Morinaga; Tomoko Emura; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Aug. 2015, Peer-reviewed
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      • Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease
        Atsushi Umemura; Tomoko Oeda; Kenji Yamamoto; Satoshi Tomita; Masayuki Kohsaka; Kwiyoung Park; Hiroshi Sugiyama; Hideyuki Sawada
        PLOS ONE, Aug. 2015, Peer-reviewed
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      • Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures
        Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama
        NATURE COMMUNICATIONS, Aug. 2015, Peer-reviewed
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      • A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts
        Junetha Syed; Anandhakumar Chandran; Ganesh N. Pandian; Junichi Taniguchi; Shinsuke Sato; Kaori Hashiya; Gengo Kashiwazaki; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Jul. 2015, Peer-reviewed
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      • A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network
        Le Han; Ganesh N. Pandian; Anandhakumar Chandran; Shinsuke Sato; Junichi Taniguchi; Gengo Kashiwazaki; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Yufang Xu; Xuhong Qian; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2015, Peer-reviewed
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      • Inducing Stem Cell Myogenesis Using NanoScript
        Sahishnu Patel; Perry T. Yin; Hiroshi Sugiyama; Ki-Bum Lee
        ACS NANO, Jul. 2015, Peer-reviewed
      • Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics
        Noriko Goto; Gyorgy Bazar; Zoltan Kovacs; Makoto Kunisada; Hiroyuki Morita; Seiichiro Kizaki; Hiroshi Sugiyama; Roumiana Tsenkova; Chikako Nishigori
        SCIENTIFIC REPORTS, Jul. 2015, Peer-reviewed
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      • DNA NANOTECHNOLOGY Measuring chloride in live cells
        Masayuki Endo; Hiroshi Sugiyama
        NATURE NANOTECHNOLOGY, Jul. 2015, Peer-reviewed
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      • Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-beta 1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model
        Jun Igarashi; Noboru Fukuda; Takashi Inoue; Shigeki Nakai; Kosuke Saito; Kyoko Fujiwara; Hiroyuki Matsuda; Takahiro Ueno; Yoshiaki Matsumoto; Takayoshi Watanabe; Hiroki Nagase; Toshikazu Bando; Hiroshi Sugiyama; Toshio Itoh; Masayoshi Soma
        PLOS ONE, May 2015, Peer-reviewed
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      • Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells
        Kohta Mohri; Eri Kusuki; Shozo Ohtsuki; Natsuki Takahashi; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        BIOMACROMOLECULES, Apr. 2015, Peer-reviewed
      • Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells
        Sahishnu Patel; Thanapat Pongkulapa; Perry T. Yin; Ganesh N. Pandian; Christopher Rathnam; Toshikazu Bando; Thangavel Vaijayanthi; Hiroshi Sugiyama; Ki-Bum Lee
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2015, Peer-reviewed
      • Mimicking Membrane-Related Biological Events by DNA Origami Nanotechnology
        Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama
        ACS NANO, Apr. 2015, Peer-reviewed
      • Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate
        Kiriko Hiraoka; Takahiro Inoue; Rhys Dylan Taylor; Takayoshi Watanabe; Nobuko Koshikawa; Hiroyuki Yoda; Ken-ichi Shinohara; Atsushi Takatori; Hirokazu Sugimoto; Yoshiaki Maru; Tadamichi Denda; Kyoko Fujiwara; Allan Balmain; Toshinori Ozaki; Toshikazu Bando; Hiroshi Sugiyama; Hiroki Nagase
        NATURE COMMUNICATIONS, Apr. 2015, Peer-reviewed
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      • Rational design of specific binding hairpin Py-Im polyamides targeting human telomere sequences
        Chuanxin Guo; Yusuke Kawamoto; Sefan Asamitsu; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2015, Peer-reviewed
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      • Synthetic strategies to identify and regulate noncoding RNAs
        Ganesh N. Pandian; Junetha Syed; Hiroshi Sugiyama
        Long Noncoding RNAs Structures and Functions, 01 Jan. 2015, Peer-reviewed
      • Development of a visible nanothermometer with a highly emissive 2 '-O-methylated guanosine analogue
        Seigi Yamamoto; Soyoung Park; Hiroshi Sugiyama
        RSC ADVANCES, 2015, Peer-reviewed
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      • Direct Observation of G-Quadruplexes and their Folding Intermediates
        A. Rajendran; Y. Li; M. Endo; H. Sugiyama
        DNA G-quadruplexes as new anticancer targets (R. De Vooght-Johnson Ed.), Future Science, 2015, Peer-reviewed
      • Tandem trimer pyrrole-imidazole polyamide probes targeting 18 base pairs in human telomere sequences
        Yusuke Kawamoto; Asuka Sasaki; Kaori Hashiya; Satoru Ide; Toshikazu Bando; Kazuhiro Maeshima; Hiroshi Sugiyama
        CHEMICAL SCIENCE, 2015, Peer-reviewed
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      • Photoreactivity of the linker region of two consecutive G-quadruplexes formed by human telomeric DNA
        Yue Li; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed
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      • Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed
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      • A novel detection technique of polyamide binding sites by photo-induced electron transfer in BrU substituted DNA
        Abhijit Saha; Fumitaka Hashiya; Seiichiro Kizaki; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed
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      • Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies
        Chandran Anandhakumar; Seiichiro Kizaki; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama
        CHEMBIOCHEM, Jan. 2015, Peer-reviewed
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      • Folding RNA-Protein Complex into Designed Nanostructures.
        Tomonori Shibata; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito
        Methods in molecular biology (Clifton, N.J.), 2015, Peer-reviewed
      • Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts
        Ganesh N. Pandian; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Kazuhiro Takashima; Junetha Syed; Le Han; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama
        ACS CHEMICAL BIOLOGY, Dec. 2014, Peer-reviewed
      • Next-Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specificity by the Addition of beta-Alanine
        Chandran Anandhakumar; Yue Li; Seiichiro Kizaki; Ganesh N. Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMBIOCHEM, Dec. 2014, Peer-reviewed
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      • Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA
        Fumitaka Hashiya; Abhijit Saha; Seiichiro Kizaki; Yue Li; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Dec. 2014, Peer-reviewed
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      • Preparation of Chemically Modified RNA Origami Nanostructures
        Masayuki Endo; Yosuke Takeuchi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        Chemistry - A European Journal, 01 Nov. 2014, Peer-reviewed
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      • Development of DNA-Based Hybrid Catalysts through Direct Ligand Incorporation: Toward Understanding of DNA-Based Asymmetric Catalysis
        Soyoung Park; Linjie Zheng; Shunsuke Kumakiri; Sohei Sakashita; Haruka Otomo; Keiichi Ikehata; Hiroshi Sugiyama
        ACS CATALYSIS, Nov. 2014, Peer-reviewed
      • Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials
        Tomohiro Takenaka; Masayuki Endo; Yuki Suzuki; Yangyang Yang; Tomoko Emura; Kumi Hidaka; Takayuki Kato; Tomoko Miyata; Keiichi Namba; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Nov. 2014, Peer-reviewed
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      • Direct Quantification of Loop Interaction and pi-pi Stacking for G-Quadruplex Stability at the Submolecular Level
        Chiran Ghimire; Soyoung Park; Keisuke Iida; Philip Yangyuoru; Haruka Otomo; Zhongbo Yu; Kazuo Nagasawa; Hiroshi Sugiyama; Hanbin Mao
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2014, Peer-reviewed
      • Preparation of Chemically Modified RNA Origami Nanostructures
        Masayuki Endo; Yosuke Takeuchi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Nov. 2014, Peer-reviewed
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      • Chemical modification of a synthetic small molecule boosts its biological efficacy against pluripotency genes in mouse fibroblasts.
        Saha A; Pandian GN; Sato S; Taniguchi J; Kawamoto Y; Hashiya K; Bando T; Sugiyama H
        ChemMedChem, Oct. 2014, Peer-reviewed
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      • Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts
        Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMMEDCHEM, Oct. 2014, Peer-reviewed
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      • Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide
        Junetha Syed; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Anandhakumar Chandran; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMISTRY & BIOLOGY, Oct. 2014, Peer-reviewed
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      • Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates
        Rhys Dylan Taylor; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        CHEMISTRY-AN ASIAN JOURNAL, Sep. 2014, Peer-reviewed
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      • Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats
        Sefan Asamitsu; Yusuke Kawamoto; Fumitaka Hashiya; Kaori Hashiya; Makoto Yamamoto; Seiichiro Kizaki; Toshikazu Bando; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 2014, Peer-reviewed
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      • NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation
        Sahishnu Patel; Dongju Jung; Perry T. Yin; Peter Carlton; Makoto Yamamoto; Toshikazu Bando; Hiroshi Sugiyama; Ki-Bum Lee
        ACS NANO, Sep. 2014, Peer-reviewed
      • A lock-and-key mechanism for the controllable fabrication of DNA origami structures
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Naohiko Shimada; Atsushi Maruyama; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, Aug. 2014, Peer-reviewed
      • Structural Evaluation of Tandem Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres
        Akiyoshi Hirata; Kiyoshi Nokihara; Yusuke Kawamoto; Toshikazu Bando; Asuka Sasaki; Satoru Ide; Kazuhiro Maeshima; Takeshi Kasama; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014, Peer-reviewed
      • Engineering RNA-Protein Complexes with Different Shapes for Imaging and Therapeutic Applications
        Eriko Osada; Yuki Suzuki; Kumi Hidaka; Hirohisa Ohno; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito
        ACS NANO, Aug. 2014, Peer-reviewed
      • Helical DNA Origami Tubular Structures with Various Sizes and Arrangements
        Masayuki Endo; Seigi Yamamoto; Tomoko Emura; Kumi Hidaka; Nobuhiro Morone; John E. Heuser; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2014, Peer-reviewed
      • Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures
        Deepak Koirala; Prakash Shrestha; Tomoko Emura; Kumi Hidaka; Shankar Mandal; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2014, Peer-reviewed
      • Single-Molecule Imaging of Dynamic Motions of Biomolecules in DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy
        Masayuki Endo; Hiroshi Sugiyama
        ACCOUNTS OF CHEMICAL RESEARCH, Jun. 2014, Peer-reviewed
      • Single Molecule Visualization and Characterization of Sox2-Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame
        Seigi Yamamoto; Debojyoti De; Kumi Hidaka; Kyeong Kyu Kim; Masayuki Endo; Hiroshi Sugiyama
        NANO LETTERS, May 2014, Peer-reviewed
      • The origin of enantioselectivity for intramolecular Friedel-Crafts reaction catalyzed by supramolecular Cu/DNA catalyst complex
        Galina P. Petrova; Zhuofeng Ke; Soyoung Park; Hiroshi Sugiyama; Keiji Morokuma
        CHEMICAL PHYSICS LETTERS, Apr. 2014, Peer-reviewed
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      • Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Apr. 2014, Peer-reviewed
      • Specific Alkylation of Human Telomere Repeat Sequences by a Tandem-Hairpin Motif of Pyrrole-Imidazole Polyamides with Indole-seco-CBI
        Makoto Yamamoto; Toshikazu Bando; Yusuke Kawamoto; Rhys Dylan Taylor; Kaori Hashiya; Hiroshi Sugiyama
        BIOCONJUGATE CHEMISTRY, Mar. 2014, Peer-reviewed
      • Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control.
        Pandian GN; Taniguchi J; Sugiyama H
        Clinical and translational medicine, Mar. 2014, Peer-reviewed
      • Dynamic Assembly/Disassembly Processes of Photoresponsive DNA Origami Nanostructures Directly Visualized on a Lipid Membrane Surface
        Yuki Suzuki; Masayuki Endo; Yangyang Yang; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2014, Peer-reviewed
      • Construction and characterization of Cy3-or Cy5-conjugated hairpin pyrrole-imidazole polyamides binding to DNA in the nucleosome
        Yong-Woon Han; Yasuo Tsunaka; Hiroaki Yokota; Tomoko Matsumoto; Gengo Kashiwazaki; Hironobu Morinaga; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Yoshie Harada
        BIOMATERIALS SCIENCE, 2014, Peer-reviewed
      • Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts
        Ganesh N. Pandian; Junichi Taniguchi; Syed Junetha; Shinsuke Sato; Le Han; Abhijit Saha; Chandran AnandhaKumar; Toshikazu Bando; Hiroki Nagase; Thangavel Vaijayanthi; Rhys D. Taylor; Hiroshi Sugiyama
        SCIENTIFIC REPORTS, Jan. 2014, Peer-reviewed
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      • Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transition
        Soyoung Park; Haruka Otomo; Linjie Zheng; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed
      • Sequence-Specific DNA Recognition by Cyclic Pyrrole-Imidazole Cysteine-Derived Polyamide Dimers
        Makoto Yamamoto; Toshikazu Bando; Hironobu Morinaga; Yusuke Kawamoto; Kaori Hashiya; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Jan. 2014, Peer-reviewed
      • G-quadruplex-binding ligand-induced DNA synapsis inside a DNA origami frame
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Hiroshi Sugiyama
        RSC ADVANCES, 2014, Peer-reviewed
      • DNA Origami Based Visualization System for Studying Site-Specific Recombination Events
        Yuki Suzuki; Masayuki Endo; Yousuke Katsuda; Keiyu Ou; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2014, Peer-reviewed
      • State-of-the-Art High-Speed Atomic Force Microscopy for Investigation of Single-Molecular Dynamics of Proteins
        Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama
        CHEMICAL REVIEWS, Jan. 2014, Peer-reviewed
      • CGmCGCG is a versatile substrate with which to evaluate Tet protein activity
        Seiichiro Kizaki; Hiroshi Sugiyama
        ORGANIC & BIOMOLECULAR CHEMISTRY, Jan. 2014, Peer-reviewed
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      • 1P316 Rational design of orthogonal gene transcription nano device on DNA origami(28. Bioengineering,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))
        Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya
        Seibutsu Butsuri, 2014
      • Amplification of fluorescent DNA through enzymatic incorporation of a highly emissive deoxyguanosine analogue
        Haruka Otomo; Soyoung Park; Seigi Yamamotoa; Hiroshi Sugiyama
        RSC ADVANCES, 2014, Peer-reviewed
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      • Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules
        Ganesh N. Pandian; Rhys D. Taylor; Syed Junetha; Abhijit Saha; Chandran Anandhakumar; Thangavel Vaijayanthi; Hiroshi Sugiyama
        BIOMATERIALS SCIENCE, 2014, Peer-reviewed
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      • Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and challenges
        Ganesh N. Pandian; Hiroshi Sugiyama
        Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, 01 Jan. 2014, Peer-reviewed
      • DNA オリガミ構造体を利用した１分子イメージングシステムの開発
        遠藤 政幸; 杉山 弘
        新材料・新素材シリーズ『超分子材料の設計と応用展開』、シーエムシー出版, 2014, Peer-reviewed
      • DNA ナノ構造体を利用したDNA 構造変化の１分子イメージング
        遠藤 政幸; 杉山 弘
        DOJIN BIOSCIENCE SERIES『１分子生物学』、化学同人, 2014, Peer-reviewed
      • AFM analysis of changes in nucleosome wrapping induced by DNA epigenetic modification
        Seiichiro Kizaki; Yuki Suzuki; Tomohiro Takenaka; Masayuki Endo; Hiroshi Sugiyama
        BIOMATERIALS SCIENCE, 2014, Peer-reviewed
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      • Controlling Electron Rebound within Four-Base pi-Stacks in Z-DNA by Changing the Sugar Moiety from Deoxy-to Ribonucleotide
        Yuta Sannohe; Seiichiro Kizaki; Shuhei Kanesato; Ayaka Fujiwara; Yue Li; Hironobu Morinaga; Ryu Tashiro; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Jan. 2014, Peer-reviewed
      • Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole-Imidazole Polyamide seco-CBI Conjugates
        Rhys Dylan Taylor; Sefan Asamitsu; Tomohiro Takenaka; Makoto Yamamoto; Kaori Hashiya; Yusuke Kawamoto; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Jan. 2014, Peer-reviewed
      • Direct observation of the dual-switching behaviors corresponding to the state transition in a DNA nanoframe
        Yangyang Yang; Masayuki Endo; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed
      • Direct analysis of Holliday junction resolving enzyme in a DNA origami nanostructure
        Yuki Suzuki; Masayuki Endo; Cristina Canas; Silvia Ayora; Juan C. Alonso; Hiroshi Sugiyama; Kunio Takeyasu
        NUCLEIC ACIDS RESEARCH, 2014, Peer-reviewed
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      • Investigation of B-Z transitions with DNA oligonucleotides containing 8-methylguanine
        Frederic Y.-H. Chen; Soyoung Park; Haruka Otomo; Sohei Sakashita; Hiroshi Sugiyama
        Artificial DNA: PNA and XNA, 2014, Peer-reviewed
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      • Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA
        Wataru Kameshima; Takumi Ishizuka; Masafumi Minoshima; Makoto Yamamoto; Hiroshi Sugiyama; Yan Xu; Makoto Komiyama
        Angewandte Chemie - International Edition, 16 Dec. 2013, Peer-reviewed
      • HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Jean-Louis Mergny; Robert J. Gorelick; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2013, Peer-reviewed
      • Regulation of B-Z Conformational Transition and Complex Formation with a Z-Form Binding Protein by Introduction of Constraint to Double-Stranded DNA by using a DNA Nanoscaffold
        Masayuki Endo; Masahiro Inoue; Yuki Suzuki; Chigusa Masui; Hironobu Morinaga; Kumi Hidaka; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Dec. 2013, Peer-reviewed
      • A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell
        Le Han; Ganesh N. Pandian; Syed Junetha; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Dec. 2013, Peer-reviewed
      • Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources
        Yan-Ling Wu; Ganesh N. Pandian; Yan-Ping Ding; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama
        CHEMISTRY & BIOLOGY, Nov. 2013, Peer-reviewed
      • Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres
        Yusuke Kawamoto; Toshikazu Bando; Fukumi Kamada; Yue Li; Kaori Hashiya; Kazuhiro Maeshima; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2013, Peer-reviewed
      • Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Jean-Louis Mergny; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Oct. 2013, Peer-reviewed
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      • Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach
        Shigeo Masuda; Jun Wu; Tomoaki Hishida; Ganesh N. Pandian; Hiroshi Sugiyama; Juan Carlos Izpisua Belmonte
        JOURNAL OF MOLECULAR CELL BIOLOGY, Oct. 2013, Peer-reviewed
      • Solid-supported DNA for asymmetric synthesis: A stepping-stone toward practical applications
        Soyoung Park; Keiichi Ikehata; Hiroshi Sugiyama
        Biomaterials Science, Oct. 2013, Peer-reviewed
      • Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′
        Yong-Woon Han; Gengo Kashiwazaki; Hironobu Morinaga; Tomoko Matsumoto; Kaori Hashiya; Toshikazu Bando; Yoshie Harada; Hiroshi Sugiyama
        Bioorganic and Medicinal Chemistry, 01 Sep. 2013, Peer-reviewed
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      • Guided Assembly of Tetramolecular G-Quadruplexes
        Liliya A. Yatsunyk; Olivier Pietrement; Delphine Albrecht; Phong Lan Thao Tran; Daniel Renciuk; Hiroshi Sugiyama; Jean-Michel Arbona; Jean-Pierre Aime; Jean-Louis Mergny
        ACS NANO, Jul. 2013, Peer-reviewed
      • RNA binding properties of novel gene silencing pyrrole-imidazole polyamides
        Akifumi Iguchi; Noboru Fukuda; Teruyuki Takahashi; Takayoshi Watanabe; Hiroyuki Matsuda; Hiroki Nagase; Toshikazu Bando; Hiroshi Sugiyama; Kazufumi Shimizu
        Biological and Pharmaceutical Bulletin, Jul. 2013, Peer-reviewed
      • Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity
        Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2013, Peer-reviewed
      • Hydrochlorothiazide Enhances UVA-Induced DNA Damage
        Makoto Kunisada; Taro Masaki; Ryusuke Ono; Hironobu Morinaga; Eiji Nakano; Flandiana Yogianti; Kunihiro Okunishi; Hiroshi Sugiyama; Chikako Nishigori
        PHOTOCHEMISTRY AND PHOTOBIOLOGY, May 2013, Peer-reviewed
      • Sequence-specific electron injection into DNA from an intermolecular electron donor
        Hironobu Morinaga; Tomohiro Takenaka; Fumitaka Hashiya; Seiichiro Kizaki; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama
        Nucleic Acids Research, Apr. 2013, Peer-reviewed
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      • Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences
        Deepak Koirala; Chiran Ghimire; Christopher Bohrer; Yuta Sannohe; Hiroshi Sugiyama; Hanbin Mao
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2013, Peer-reviewed
      • Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their gamma-turn
        Thangavel Vaijayanthi; Toshikazu Bando; Kaori Hashiya; Ganesh N. Pandian; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2013, Peer-reviewed
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      • Direct and real-time observation of rotary movement of a DNA nanomechanical device
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama
        Journal of the American Chemical Society, 23 Jan. 2013, Peer-reviewed
      • Photoreactivities of 5-Bromouracil-containing RNAs
        Hironobu Morinaga; Seiichiro Kizaki; Tomohiro Takenaka; Shuhei Kanesato; Yuta Sannohe; Ryu Tashiro; Hiroshi Sugiyama
        Bioorganic and Medicinal Chemistry, 15 Jan. 2013, Peer-reviewed
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      • DNA nanomachines that move on the DNA origami structures
        M. Endo; H. Sugiyama
        Kobunshi, 2013, Peer-reviewed
      • DNA origami technology for biomaterials applications
        Masayuki Endo; Yangyang Yang; Hiroshi Sugiyama
        BIOMATERIALS SCIENCE, 2013, Peer-reviewed
      • RNA-templated DNA origami structures
        Masayuki Endo; Seigi Yamamoto; Koichi Tatsumi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed
      • Helical Structure and Circular Dichroism Spectra of DNA: A Theoretical Study
        Tomoo Miyahara; Hiroshi Nakatsuji; Hiroshi Sugiyama
        JOURNAL OF PHYSICAL CHEMISTRY A, Jan. 2013, Peer-reviewed
      • Control of the two-dimensional crystallization of DNA origami with various loop arrangements
        Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed
      • The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases
        Jing Liang; Yan-Ling Wu; Bing-Jia Chen; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama
        INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2013, Peer-reviewed
      • 3P306 Construction and functional analysis of DNA origami base DNA-RNAP hybrid nanomachine(28.Bioengineering,Poster,The 51st Annual Meeting of the Biophysical Society of Japan)
        Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya
        Seibutsu Butsuri, 2013
      • GSM1289291: HDF_SAHA-PIP9_rep1
        Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi
        Gene Expression Omnibus, 2013, Peer-reviewed
      • E-GEOD-53317.raw.1.zip
        Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi
        ArrayExpress Archive, 2013, Peer-reviewed
      • E-GEOD-53316.processed.1.zip
        Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N
        ArrayExpress Archive, 2013, Peer-reviewed
      • E-GEOD-53316.idf.txt
        Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N
        ArrayExpress Archive, 2013, Peer-reviewed
      • A-GEOD-13497.adf.txt
        Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi
        ArrayExpress Archive, 2013, Peer-reviewed
      • ChemInform Abstract: Deciphering DNA-Based Asymmetric Catalysis Through Intramolecular Friedel-Crafts Alkylations.
        Park Soyoung; Ikehata Keiichi; Watabe Ryo; Hidaka Yuta; Rajendran Arivazhagan; Sugiyama Hiroshi
        ChemInform, 2013, Peer-reviewed
      • DNAオリガミ構造体と高速原子間力顕微鏡を用いた１分子観察系の構築
        遠藤 政幸; 杉山 弘
        生物物理, 2013, Peer-reviewed
      • G-quadruplex nanostructures probed at the single molecular level by force-based methods
        S. Dhakal; H. Mao; A. Rajendran; M. Endo; H. Sugiyama
        Guanine quartets: Structure and application, Royal Society of Chemistry, 2013, Peer-reviewed
      • Strategies to modulate heritable epigenetic defects in cellular machinery: Lessons from nature
        Ganesh N. Pandian; Hiroshi Sugiyama
        Pharmaceuticals, 27 Dec. 2012, Peer-reviewed
      • Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants
        Yong-Woon Han; Tomoko Matsumoto; Hiroaki Yokota; Gengo Kashiwazaki; Hironobu Morinaga; Kaori Hashiya; Toshikazu Bando; Yoshie Harada; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, Dec. 2012, Peer-reviewed
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      • Photo-Controllable DNA Origami Nanostructures Assembling into Predesigned Multiorientational Patterns
        Yangyang Yang; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2012, Peer-reviewed
      • DNA as a Chiral Scaffold for Asymmetric Synthesis
        Soyoung Park; Hiroshi Sugiyama
        MOLECULES, Nov. 2012, Peer-reviewed
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      • Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes
        Thangavel Vaijayanthi; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama
        CHEMBIOCHEM, Oct. 2012, Peer-reviewed
      • Synthesis of Pyrrole-Imidazole Polyamide seco-1-Chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole Conjugates with a Vinyl Linker Recognizing a 7 bp DNA Sequence
        Toshiki Takagaki; Toshikazu Bando; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012, Peer-reviewed
      • A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts
        Ganesh N. Pandian; Yusuke Nakano; Shinsuke Sato; Hironobu Morinaga; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama
        SCIENTIFIC REPORTS, Jul. 2012, Peer-reviewed
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      • Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells
        Kohta Mohri; Makiya Nishikawa; Natsuki Takahashi; Tomoki Shiomi; Nao Matsuoka; Kohei Ogawa; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura
        ACS NANO, Jul. 2012, Peer-reviewed
      • Recognition by Nonaromatic and Stereochemical Subunit-Containing Polyamides of the Four Watson-Crick Base Pairs in the DNA Minor Groove
        Hong-Fei Zhang; Yan-Ling Wu; Shi-Kun Jiang; Pu Wang; Hiroshi Sugiyama; Xing-Lai Chen; Wen Zhang; Yan-Juan Ji; Chuan-Xin Guo
        CHEMBIOCHEM, Jun. 2012, Peer-reviewed
      • Programmable genetic switches to control transcriptional machinery of pluripotency
        Ganesh N. Pandian; Hiroshi Sugiyama
        BIOTECHNOLOGY JOURNAL, Jun. 2012, Peer-reviewed
      • Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes
        Ganesh N. Pandian; Akimichi Ohtsuki; Toshikazu Bando; Shinsuke Sato; Kaori Hashiya; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2012, Peer-reviewed
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      • Sequence-Selective Single-Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold
        Tomofumi Yoshidome; Masayuki Endo; Gengo Kashiwazaki; Kumi Hidaka; Toshikazu Bando; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2012, Peer-reviewed
      • Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole-N-Methylimidazole Polyamide Conjugates
        Gengo Kashiwazaki; Toshikazu Bando; Tomofumi Yoshidome; Seiji Masui; Toshiki Takagaki; Kaori Hashiya; Ganesh N. Pandian; Junichi Yasuoka; Kazunari Akiyoshi; Hiroshi Sugiyama
        JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed
      • A DNA-based molecular motor that can navigate a network of tracks
        Shelley F. J. Wickham; Jonathan Bath; Yousuke Katsuda; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Andrew J. Turberfield
        NATURE NANOTECHNOLOGY, Mar. 2012, Peer-reviewed
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      • Single strand DNA catenane synthesis using the formation of G-quadruplex structure
        Yuta Sannohe; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed
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      • Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure
        Masayuki Endo; Ryoji Miyazaki; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2012, Peer-reviewed
      • Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure
        Masayuki Endo; Koichi Tatsumi; Kosuke Terushima; Yousuke Katsuda; Kumi Hidaka; Yoshie Harada; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed
      • Zinc-Finger Proteins for Site-Specific Protein Positioning on DNA-Origami Structures
        Eiji Nakata; Fong Fong Liew; Chisana Uwatoko; Shigeki Kiyonaka; Yasuo Mori; Yousuke Katsuda; Masayuki Endo; Hiroshi Sugiyama; Takashi Morii
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed
      • Immunotherapies: The Blockade of Inhibitory Signals
        Yan-Ling Wu; Jing Liang; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama
        INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2012, Peer-reviewed
      • Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure
        Masayuki Endo; Yangyang Yang; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed
      • Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations
        Soyoung Park; Keiichi Ikehata; Ryo Watabe; Yuta Hidaka; Arivazhagan Rajendran; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed
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      • SWI/SNF-mediated chromatin remodeling induces Z-DNA formation on a nucleosome
        Niveen Mulholland; Yan Xu; Hiroshi Sugiyama; Keji Zhao
        CELL AND BIOSCIENCE, Jan. 2012, Peer-reviewed
      • Dna origami: Synthesis and self-assembly
        Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama
        Current Protocols in Nucleic Acid Chemistry, 2012, Peer-reviewed
      • Structural and functional analysis of proteins by high-speed atomic force microscopy
        Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama
        Advances in Protein Chemistry and Structural Biology, 2012, Peer-reviewed
      • Intramolecular folding in three tandem guanine repeats of human telomeric DNA
        Deepak Koirala; Tomoko Mashimo; Yuta Sannohe; Zhongbo Yu; Hanbin Mao; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed
      • Single-Molecule Analysis Using DNA Origami
        Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed
      • Discrimination between T/A and A/T Base Pairs of Pyrrole-Imidazole Polyamides Substituted with Chiral ss-Hydroxy-?-Aminobutyric Acid/ss-Alanine Pairs
        Wen Zhang; Shi-Kun Jiang; Yan-Ling Wu; Chuan-Xin Guo; Hong-Fei Zhang; Hiroshi Sugiyama; Xing-Lai Chen
        CHEMBIOCHEM, Jan. 2012, Peer-reviewed
      • 3PT111 Construction and functional analysis of DNA origami base DNA-RNAP hybrid nanomachine(The 50th Annual Meeting of the Biophysical Society of Japan)
        Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya
        Seibutsu Butsuri, 2012
      • ChemInform Abstract: Single-Molecule Analysis Using DNA Origami
        Rajendran Arivazhagan; Endo Masayuki; Sugiyama Hiroshi
        ChemInform, 2012, Peer-reviewed
      • DNAオリガミによる１分子観察系の構築
        遠藤 政幸; 杉山 弘
        『疾患克服を目指したケミカルバイオロジー』実験医学2012年増刊号, 2012, Peer-reviewed
      • DNAオリガミ構造体と１分子観察への応用
        遠藤 政幸; 杉山 弘
        化学工業, 2012, Peer-reviewed
      • Zinc finger proteins as adaptor for locating proteins at specific addresses of DNA origami
        E. Nakata; L. Fong; C. Uwatoko; S. Kiyonaka; Y. Mori; Y. Katsuda; M. Endo; H. Sugiyama; T. Morii
        Angew. Chem. Int. Ed, 2012, Peer-reviewed
      • Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts
        Ganesh N. Pandian; Ken-ichi Shinohara; Akimichi Ohtsuki; Yusuke Nakano; Minoshima Masafumi; Toshikazu Bando; Hiroki Nagase; Yasuhiro Yamada; Akira Watanabe; Naohiro Terada; Shinsuke Sato; Hironobu Morinaga; Hiroshi Sugiyama
        CHEMBIOCHEM, Dec. 2011, Peer-reviewed
      • DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization
        Ai Yasuda; Kohji Noguchi; Masafumi Minoshima; Gengo Kashiwazaki; Teru Kanda; Kazuhiro Katayama; Junko Mitsuhashi; Toshikazu Bando; Hiroshi Sugiyama; Yoshikazu Sugimoto
        CANCER SCIENCE, Dec. 2011, Peer-reviewed
      • DNA Origami-based Construction of Meso-scale Multi-dimensional Architects and Expression of the Functionality in the Designed DNA Nanospace
        Masayuki Endo; Hiroshi Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Dec. 2011, Peer-reviewed
      • Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition in the DNA Minor Groove
        Hironobu Morinaga; Toshikazu Bando; Toshiki Takagaki; Makoto Yamamoto; Kaori Hashiya; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2011, Peer-reviewed
      • Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation
        Toshiki Takagaki; Toshikazu Bando; Masaaki Kitano; Kaori Hashiya; Gengo Kashiwazaki; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Oct. 2011, Peer-reviewed
      • A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
        Deepak Koirala; Soma Dhakal; Beth Ashbridge; Yuta Sannohe; Raphael Rodriguez; Hiroshi Sugiyama; Shankar Balasubramanian; Hanbin Mao
        NATURE CHEMISTRY, Oct. 2011, Peer-reviewed
      • SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome
        N. Mulholland; Y. Xu; H. Sugiyama; K. Zhao
        J. Am. Chem. Soc., Oct. 2011, Peer-reviewed
      • Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly
        Arivazhagan Rajendran; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2011, Peer-reviewed
      • Direct observation of stepwise movement of a synthetic molecular transporter
        Shelley F. J. Wickham; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Jonathan Bath; Hiroshi Sugiyama; Andrew J. Turberfield
        NATURE NANOTECHNOLOGY, Mar. 2011, Peer-reviewed
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      • Photocontrollable Sequence-Specific DNA Alkylation by a Pyrrole-Imidazole Polyamide seco-CBI Conjugate
        Soyoung Park; Toshikazu Bando; Ken-ichi Shinohara; Shigeki Nishijima; Hiroshi Sugiyama
        BIOCONJUGATE CHEMISTRY, Feb. 2011, Peer-reviewed
      • Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces
        Arivazhagan Rajendran; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        ACS NANO, Jan. 2011, Peer-reviewed
      • Lightweight Actuator Structure With SMA Honeycomb Core and CFRP Skins
        Yoji Okabe; Hiroshi Sugiyama; Toru Inayoshi
        JOURNAL OF MECHANICAL DESIGN, Jan. 2011, Peer-reviewed
      • Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-beta 1 promoter
        Hiroyuki Matsuda; Noboru Fukuda; Takahiro Ueno; Mayumi Katakawa; Xiaofei Wang; Takayoshi Watanabe; Sei-Ichi Matsui; Takahiko Aoyama; Kosuke Saito; Toshikazu Bando; Yoshiaki Matsumoto; Hiroaki Nagase; Koichi Matsumoto; Hiroshi Sugiyama
        KIDNEY INTERNATIONAL, Jan. 2011, Peer-reviewed
      • Recent progress in DNA origami unit 12.8 technology
        Masayuki Endo; Hiroshi Sugiyama
        Current Protocols in Nucleic Acid Chemistry, 2011, Peer-reviewed
      • Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold
        Masayuki Endo; Yangyang Yang; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed
      • Direct AFM observation of an opening event of a DNA cuboid constructed via a prism structure
        Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama
        ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, Peer-reviewed
      • Two-dimensional DNA origami assemblies using a four-way connector
        Masayuki Endo; Tsutomu Sugita; Arivazhagan Rajendran; Yousuke Katsuda; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama
        CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed
      • DNAナノ空間での生体分子のコントロールと直接的な観察
        遠藤 政幸; 杉山 弘
        パリティ, 2011, Peer-reviewed
      • Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure
        Yuta Sannohe; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2010, Peer-reviewed
      • Folding Pathways of Human Telomeric Type-1 and Type-2 G-Quadruplex Structures
        Tomoko Mashimo; Hirotaka Yagi; Yuta Sannohe; Arivazhagan Rajendran; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2010, Peer-reviewed
      • The Distance Between Donor and Acceptor Affects the Proportion of C1 ' and C2 ' Oxidation Products of DNA in a U-Br-Containing Excess Electron Transfer System
        Ryu Tashiro; Akimichi Ohtsuki; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2010, Peer-reviewed
      • Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates
        Gengo Kashiwazaki; Toshikazu Bando; Ken-ichi Shinohara; Masafumi Minoshima; Hana Kumamoto; Shigeki Nishijima; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2010, Peer-reviewed
      • A Chiral Wedge Molecule Inhibits Telomerase Activity
        Ken-ichi Shinohara; Yuta Sannohe; Shuji Kaieda; Ken-ichi Tanaka; Hideji Osuga; Hidetoshi Tahara; Yan Xu; Takashi Kawase; Toshikazu Bando; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2010, Peer-reviewed
      • Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition
        Ken-Ichi Shinohara; Toshikazu Bando; Hiroshi Sugiyama
        ANTI-CANCER DRUGS, Mar. 2010, Peer-reviewed
      • Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide
        Xiaofei Wang; Hiroki Nagase; Takayoshi Watanabe; Hiroyuki Nobusue; Tsukasa Suzuki; Yukihiro Asami; Yui Shinojima; Hiroyuki Kawashima; Keiko Takagi; Rajeev Mishra; Jun Igarashi; Makoto Kimura; Tadatoshi Takayama; Noboru Fukuda; Hiroshi Sugiyama
        CANCER SCIENCE, Mar. 2010, Peer-reviewed
      • Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure
        Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2010, Peer-reviewed
      • Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI
        Masafumi Minoshima; Toshikazu Bando; Ken-ichi Shinohara; Gengo Kashiwazaki; Shigeki Nishijima; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2010, Peer-reviewed
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      • Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content
        Shigeki Nishijima; Ken-ichi Shinohara; Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 2010, Peer-reviewed
      • Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes
        Masafumi Minoshima; James C. Chou; Sophie Lefebvre; Toshikazu Bando; Ken-ichi Shinohara; Joel M. Gottesfeld; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 2010, Peer-reviewed
      • RNA ポリメラーゼのDNA ナノ構造上 での１分子観測
        照島功祐; 遠藤政幸; 勝田陽介; 日高久美; 杉山弘
        日本化学会第90 春季年会, 大阪,2010年3 月26 日-3 月 29 日, 2010, Peer-reviewed
      • DNA-Based Hybrid Catalysts for Asymmetric Organic Synthesis
        Soyoung Park; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, Peer-reviewed
      • Overview of formation of G-quadruplex structures
        Yuta Sannohe; Hiroshi Sugiyama
        Current Protocols in Nucleic Acid Chemistry, 2010, Peer-reviewed
      • Error-prone translesion DNA synthesis by Escherichia coli DNA polymerase IV (DinB) on templates containing 1,2-dihydro-2-oxoadenine
        Masaki Hori; Shin-Ichiro Yonekura; Takehiko Nohmi; Petr Gruz; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama
        Journal of Nucleic Acids, 2010, Peer-reviewed
      • A Versatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair
        Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, Peer-reviewed
      • Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity
        Hiroshi Tanaka; Yoshikazu Tanaka; Masafumi Minoshima; Sho Yamaguchi; Shinichiro Fuse; Takayuki Doi; Susumu Kawauchi; Hiroshi Sugiyama; Takashi Takahashi
        CHEMICAL COMMUNICATIONS, 2010, Peer-reviewed
      • Programmed-Assembly System Using DNA Jigsaw Pieces
        Masayuki Endo; Tsutomu Sugita; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, 2010, Peer-reviewed
      • Synthesis and properties of PI polyamide-SAHA conjugate
        Akimichi Ohtsuki; Makoto T. Kimura; Masafumi Minoshima; Tsukasa Suzuki; Maki Ikeda; Toshikazu Bando; Hiroki Nagase; Ken-ichi Shinohara; Hiroshi Sugiyama
        TETRAHEDRON LETTERS, Dec. 2009, Peer-reviewed
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      • Photochemistry of 5-Bromouracil- or 5-Iodouracil-containing DNA: Probe for DNA Structure and Charge Transfer Along DNA
        Ryu Tashiro; Hiroshi Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Dec. 2009, Peer-reviewed
      • Eukaryotic DNA polymerases alpha, beta and epsilon incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone.
        Katsuhito Kino; Kaoru Sugasawa; Takeshi Mizuno; Toshikazu Bando; Hiroshi Sugiyama; Masaki Akita; Hiroshi Miyazawa; Fumio Hanaoka
        Chembiochem : a European journal of chemical biology, 02 Nov. 2009, Peer-reviewed
      • DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms
        Masayuki Endo; Kumi Hidaka; Takayuki Kato; Keiichi Namba; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2009, Peer-reviewed
      • Chemical Approaches to DNA Nanotechnology
        Masayuki Endo; Hiroshi Sugiyama
        CHEMBIOCHEM, Oct. 2009, Peer-reviewed
      • Reactivity of 5-Halopyrimidines in Nucleic Acids
        Ryu Tashiro; Hiroshi Sugiyama
        Radical and Radical Ion Reactivity in Nucleic Acid Chemistry, 28 Sep. 2009, Peer-reviewed
      • Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region
        Hironobu Morinaga; Shin-Ichiro Yonekura; Nobuya Nakamura; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama
        DNA REPAIR, Jul. 2009, Peer-reviewed
      • Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression
        Tsukasa Suzuki; Yukihiro Asami; Teruyuki Takahashi; Xiaofei Wang; Takayoshi Watanabe; Toshikazu Bando; Hiroshi Sugiyama; Noboru Fukuda; Hiroki Nagase
        JOURNAL OF ANTIBIOTICS, Jun. 2009, Peer-reviewed
      • Pharmacokinetic Modeling and Prediction of Plasma Pyrrole-Imidazole Polyamide Concentration in Rats Using Simultaneous Urinary and Biliary Excretion Data
        Takashi Nagashima; Takahiko Aoyama; Tsubasa Yokoe; Akiko Fukasawa; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2009, Peer-reviewed
      • Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry
        Takashi Nagashima; Takahiko Aoyama; Akiko Fukasawa; Satoshi Watabe; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Apr. 2009, Peer-reviewed
      • KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli
        Qiu-Mei Zhang-Akiyama; Hironobu Morinaga; Masahiro Kikuchi; Shin-Ichiro Yonekura; Hiroshi Sugiyama; Kazuo Yamamoto; Shuji Yonei
        NUCLEIC ACIDS RESEARCH, Apr. 2009, Peer-reviewed
      • The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides
        Yuta Sannohe; Kyosuke Sato; Akimasa Matsugami; Ken-ichi Shinohara; Tomoko Mashimo; Masato Katahira; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2009, Peer-reviewed
      • A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function
        Takahiro Ueno; Noboru Fukuda; Akiko Tsunemi; En-Hui Yao; Hiroyuki Matsuda; Kazunobu Tahira; Taro Matsumoto; Koichi Matsumoto; Yoshiaki Matsumoto; Hiroki Nagase; Hiroshi Sugiyama; Tatsuya Sawamura
        JOURNAL OF HYPERTENSION, Mar. 2009, Peer-reviewed
      • Pharmacokinetics of Pyrrole-imidazole Polyamides after Intravenous Administration in Rat
        Akiko Fukasawa; Takahiko Aoyama; Takashi Nagashima; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        BIOPHARMACEUTICS & DRUG DISPOSITION, Mar. 2009, Peer-reviewed
      • A pyrrole-imidazole polyamide targeting transforming growth factor-beta 1 inhibits restenosis and preserves endothelialization in the injured artery
        En-Hui Yao; Noboru Fukuda; Takahiro Ueno; Hiroyuki Matsuda; Hiroki Nagase; Yoshiaki Matsumoto; Hiroshi Sugiyama; Koichi Matsumoto
        CARDIOVASCULAR RESEARCH, Mar. 2009, Peer-reviewed
      • Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design
        Gengo Kashiwazaki; Toshikazu Bando; Ken-ichi Shinohara; Masafumi Minoshima; Shigeki Nishijima; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2009, Peer-reviewed
      • Erratum: Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (The Journal of Antibiotics (2009) 62 (345) doi:10.1038/ja.2009.42))
        T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase
        Journal of Antibiotics, 2009, Peer-reviewed
      • Design of a G-Quadruplex Topology through Glycosidic Bond Angles
        Mateus Webba da Silva; Marko Trajkovski; Yuta Sannohe; Nason Ma'ani Hessari; Hiroshi Sugiyama; Janez Plavec
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed
      • Stable Lariat Formation Based on a G-Quadruplex Scaffold
        Yan Xu; Hiroyuki Sato; Yuta Sannohe; Ken-ichi Shinohara; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2008, Peer-reviewed
      • Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe
        Jun Fujimoto; Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Shigeki Nishijima; Ken-ichi Shinohara; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2008, Peer-reviewed
      • Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression
        Teruyuki Takahashi; Yukihiro Asami; Eiko Kitamura; Tsukasa Suzuki; Xiaofei Wang; Jun Igarashi; Aiko Morohashi; Yui Shinojima; Hisao Kanou; Kosuke Saito; Toshiaki Takasu; Hiroki Nagase; Yuichi Harada; Kazumichi Kuroda; Takayoshi Watanabe; Satoshi Kumamoto; Takahiko Aoyama; Yoshiaki Matsumoto; Toshikazu Bando; Hiroshi Sugiyama; Chikako Yoshida-Noro; Noboru Fukuda; Nariyuki Hayashi
        CHEMISTRY & BIOLOGY, Aug. 2008, Peer-reviewed
      • G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution
        Kenji Okamoto; Yuta Sannohe; Tomoko Mashimo; Hiroshi Sugiyama; Masahide Terazima
        BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2008, Peer-reviewed
      • Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery After Injury
        En-Hui Yao; Noboru Fukuda; Takahiro Ueno; Hiroyuki Matsuda; Koichi Matsumoto; Hiroki Nagase; Yoshiaki Matsumoto; Ayako Takasaka; Kazuo Serie; Hiroshi Sugiyama; Tatsuya Sawamura
        HYPERTENSION, Jul. 2008, Peer-reviewed
      • Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers
        Jun Fujimoto; Toshikazu Bando; Masafumi Minoshima; Shinsuke Uchida; Makoto Iwasaki; Ken-ichi Shinohara; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2008, Peer-reviewed
      • Pyrrole-imidazole hairpin polyamides with high affinity at 5CGCG3 DNA sequence; influence of cytosine methylation on binding
        Masafumi Minoshima; Toshikazu Bando; Shunta Sasaki; Jun Fujimoto; Hiroshi Sugiyama
        NUCLEIC ACIDS RESEARCH, May 2008, Peer-reviewed
      • Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition
        Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Ken-ichi Shinohara; Shunta Sasaki; Akimichi Ohtsuki; Masataka Murakami; Satomi Nakazono; Hiroshi Suglyarna; Jun Fujimoto
        BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2008, Peer-reviewed
      • Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides
        Shunta Sasaki; Toshikazu Bando; Masafumi Minoshima; Ken-ichi Shinohara; Hiroshi Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, 2008, Peer-reviewed
      • Photoreaction of iodouracil in DNA duplex; C-I bond is cleaved via two different pathways 'homolysis and heterolysis'
        Ryu Tashiro; Kenta Nakamura; Hiroshi Sugiyama
        TETRAHEDRON LETTERS, Jan. 2008, Peer-reviewed
      • The androgen receptor as putative therapeutic target in hormone-refractory prostate cancer
        Yukio Kageyama; Nobuhiko Hyochi; Kazunori Kihara; Hiroshi Sugiyama
        RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, Nov. 2007, Peer-reviewed
      • Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma
        Akiko Fukasawa; Takashi Nagashima; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Nov. 2007, Peer-reviewed
      • Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides
        Toshikazu Bando; Jun Fujimoto; Masafumi Minoshima; Ken-ichi Shinohara; Shunta Sasaki; Gengo Kashiwazaki; Masatoshi Mizumura; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2007, Peer-reviewed
      • Recombinant Schizosaccharomyces pombe nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group
        Shin-Ichiro Yonekura; Nobuya Nakamura; Takashi Doi; Hiroshi Sugiyama; Kazuo Yamamoto; Shuji Yonei; Qiu-Mei Zhang
        JOURNAL OF RADIATION RESEARCH, Sep. 2007, Peer-reviewed
      • First International Meeting on Quadruplex DNA
        W. David Wilson; Hiroshi Sugiyama
        ACS CHEMICAL BIOLOGY, Sep. 2007, Peer-reviewed
      • Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solution
        Akimasa Matsugami; Yan Xu; Yuuki Noguchi; Hiroshi Sugiyama; Masato Katahira
        FEBS JOURNAL, Jul. 2007, Peer-reviewed
      • Photoreaction at 5 '-(G/C)AA(Br)UT-3 ' sequence in duplex DNA: Efficent generation of uracil-5-yl radical by charge transfer
        Takayoshi Watanabe; Ryu Tashiro; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2007, Peer-reviewed
      • Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta.
        Masatomi Shimizu; Petr Gruz; Hiroyuki Kamiya; Chikahide Masutani; Yan Xu; Yukio Usui; Hiroshi Sugiyama; Hideyoshi Harashima; Fumio Hanaoka; Takehiko Nohmi
        Biochemistry, 08 May 2007, Peer-reviewed
      • Chemical biology that controls DNA structure and function: Lessons in organic chemistry from nature
        Hiroshi Sugiyama
        BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, May 2007, Peer-reviewed
      • DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation
        Masafumi Minoshima; Toshikazu Bando; Shunta Sasaki; Ken-ichi Shinohara; Tatsuhiko Shimizu; Jun Fujimoto; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2007, Peer-reviewed
      • I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes
        Yan Xu; Yuuka Hirao; Yoshifumi Nishimura; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2007, Peer-reviewed
      • Photochemical determination of different DNA structures
        Yan Xu; Ryu Tashiro; Hiroshi Sugiyama
        NATURE PROTOCOLS, 2007, Peer-reviewed
      • Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells
        Mikako Hirota; Tsuyoshi Fujiwara; Satoru Mineshita; Hiroshi Sugiyama; Hirobumi Teraoka
        INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, Peer-reviewed
      • Synthesis and biological properties of pyrrole-imidazole polyamide conjugates.
        Minoshima M; Sasaki S; Fujimoto J; Shinohara K; Bando T; Sugiyama H
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Folding pathways of human telomeric hybrid G-quadruplex structure.
        Mashimo T; Sugiyama H
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Sequence-specific alkylation by a tandem motif of pyrrole-imidazole CBI conjugate.
        Sasaki S; Minoshima M; Fujimoto J; Shinohara K; Bando T; Sugiyama H
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides
        Toshikazu Bando; Hiroshi Sugiyama
        ACCOUNTS OF CHEMICAL RESEARCH, Dec. 2006, Peer-reviewed
      • Base pair recognition of the stereochemically alpha-substituted gamma-turn of pyrrole/imidazole hairpin polyamides
        Wen Zhang; Masafumi Minoshima; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2006, Peer-reviewed
      • Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers
        Shunta Sasaki; Toshikazu Bando; Masafumi Minoshima; Tatsuhiko Shimizu; Ken-ichi Shinohara; Toshiyasu Takaoka; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006, Peer-reviewed
      • The new models of the human telomere d[AGGG(TTAGGG)(3)] in K+ solution
        Yan Xu; Yuki Noguchi; Hiroshi Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2006, Peer-reviewed
      • Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5 '-TG-3 ' reader in DNA minor groove
        Wen Zhang; Toshikazu Bando; Hiroshi Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2006, Peer-reviewed
      • Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition
        T Bando; S Sasaki; M Minoshima; C Dohno; K Shinohara; A Narita; H Sugiyama
        BIOCONJUGATE CHEMISTRY, May 2006, Peer-reviewed
      • Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element
        Y Kageyama; H Sugiyama; H Ayame; A Iwai; Y Fujii; LE Huang; S Kizaka-Kondoh; M Hiraoka; K Kihara
        ACTA ONCOLOGICA, Apr. 2006, Peer-reviewed
      • Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker
        K Shinohara; T Bando; S Sasaki; Y Sakakibara; M Minoshima; H Sugiyama
        CANCER SCIENCE, Mar. 2006, Peer-reviewed
      • Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta 1 promoter for treatment of progressive renal diseases
        Noboru Fukuda; Takahiro Ueno; Yoshiko Tahira; Hirohito Ayame; Wen Zhang; Toshikazu Bando; Hiroshi Sugiyama; Satoshi Saito; Koichi Matsumoto; Hideo Mugishima; Kazuo Serie
        JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Feb. 2006, Peer-reviewed
      • Photochemical approach to probing different DNA structures
        Y Xu; H Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed
      • Alkylation of template strand of coding region causes effective gene silencing
        K Shinohara; S Sasaki; M Minoshima; T Bando; H Sugiyama
        NUCLEIC ACIDS RESEARCH, 2006, Peer-reviewed
      • Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)
        Y Xu; H Sugiyama
        NUCLEIC ACIDS RESEARCH, 2006, Peer-reviewed
      • Synthesis and evaluation of sequence-specific DNA alkylating agents: effect of alkylation subunits.
        Shimizu T; Sasaki S; Minoshima M; Shinohara K; Bando T; Sugiyama H
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • Molecular design of DNA alkylating pyrrole-imidazole polyamides with longer recognition sequence.
        Minoshima M; Sasaki S; Shinohara K; Shimizu T; Bando T; Sugiyama H
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta 1 gene
        YM Lai; N Fukuda; T Ueno; H Matsuda; S Saito; K Matsumoto; H Ayame; T Bando; H Sugiyama; H Mugishima; K Serie
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 2005, Peer-reviewed
      • The chemical biology that controls DNA function and structure
        T Bando; H Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Oct. 2005, Peer-reviewed
      • Specific adenine alkylation by pyrrole-imidazole CBI conjugates
        T Bando; A Narita; S Sasaki; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2005, Peer-reviewed
      • UVR-induced G-C to C-G transversions from oxidative DNA damage
        K Kino; H Sugiyama
        MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Apr. 2005, Peer-reviewed
      • 5-Exo versus 6-endo cyclization of nucleoside 2-sila-5-hexenyl radicals: Reaction of 6-(bromomethyl)dimethylsilyl 1 ',2 '-unsaturated uridines
        J Ogamino; H Mizunuma; H Kumamoto; S Takeda; K Haraguchi; KT Nakamura; H Sugiyama; H Tanaka
        JOURNAL OF ORGANIC CHEMISTRY, Mar. 2005, Peer-reviewed
      • Biomolecule-based switching devices that respond inversely to thermal stimuli
        R Tashiro; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2005, Peer-reviewed
      • DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNElL1 and hNTH1 enzymes in human cells
        QM Zhang; S Yonekura; M Takao; A Yasui; H Sugiyama; S Yonei
        DNA REPAIR, Jan. 2005, Peer-reviewed
      • Efficient generation of 2 '-deoxyuridin-5-yl at 5 '(G/C)AA(x)U(x)U-3 ' (X = Br, I) sequences in duplex DNA under UV irradiation
        T Watanabe; T Bando; Y Xu; R Tashiro; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2005, Peer-reviewed
      • Binding of distamycin A to UV-damaged DNA
        A Inase; TS Kodama; J Sharif; Y Xu; H Ayame; H Sugiyama; S Iwai
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2004, Peer-reviewed
      • Enantioselective DNA alkylation by a pyrrole-imidazole S-CIB conjugate
        T Bando; A Narita; K Asada; H Ayame; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2004, Peer-reviewed
      • (P)-helicene displays chiral selection in binding to Z-DNA
        Y Xu; YX Zhang; H Sugiyama; T Umano; H Osuga; K Tanaka
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2004, Peer-reviewed
      • Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-lodouracil-containing antiparallel G-quartet
        Y Xu; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2004, Peer-reviewed
      • Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides
        K Shinohara; A Narita; T Oyoshi; T Bando; H Teraoka; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2004, Peer-reviewed
      • Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide
        MSRC Murty; H Sugiyama
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2004, Peer-reviewed
      • Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.
        Katsuhito Kino; Yuichiro Shimizu; Kaoru Sugasawa; Hiroshi Sugiyama; Fumio Hanaoka
        Biochemistry, 16 Mar. 2004, Peer-reviewed
      • C-H to N substitution dramatically alters the sequence-specific DNA alkylation, cytotoxicity, and expression of human cancer cell lines
        T Bando; A Narita; A Iwai; K Kihara; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2004, Peer-reviewed
      • Unique charge transfer properties of the four-base pi-stacks in Z-DNA
        R Tashiro; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2003, Peer-reviewed
      • 8-methylguanosine: A powerful Z-DNA stabilizer
        Y Xu; R Ikeda; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2003, Peer-reviewed
      • Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides
        T Bando; H Iida; ZF Tao; A Narita; N Fukuda; T Yamori; H Sugiyama
        CHEMISTRY & BIOLOGY, Aug. 2003, Peer-reviewed
      • Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide
        R Takahashi; T Bando; H Sugiyama
        BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2003, Peer-reviewed
      • Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases AP lyases in Saccharomyces cerevisiae
        QM Zhang; K Hashiguchi; K Kino; H Sugiyama; S Yonei
        INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, May 2003, Peer-reviewed
      • Inhibition of transcription at a coding sequence by alkylating polyamide
        T Oyoshi; W Kawakami; A Narita; T Bando; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2003, Peer-reviewed
      • Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates
        T Bando; A Narita; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2003, Peer-reviewed
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      • Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases
        M Hori; S Yonei; H Sugiyama; K Kino; K Yamamoto; QM Zhang
        NUCLEIC ACIDS RESEARCH, Feb. 2003, Peer-reviewed
      • Efficient C2 'alpha-hydroxylation of deoxyribose in protein-induced Z-form DNA
        T Oyoshi; K Kawai; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2003, Peer-reviewed
      • Photoreactivity of 5-iodouracil-containing telomeric DNA.
        Y. Xu; H. Sugiyama
        Nucleic acids research. Supplement (2001), 2003, Peer-reviewed
      • Photochemistry of bromouracil containing Z-DNA.
        R. Tashiro; H. Sugiyama
        Nucleic acids research. Supplement (2001), 2003, Peer-reviewed
      • Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides.
        H. Ayame; T. Saito; T. Bando; N. Fukuda; H. Sugiyama
        Nucleic acids research. Supplement (2001), 2003, Peer-reviewed
      • Towards artificial repair of UV-damaged DNA: studies on drug binding and alkali hydrolysis.
        S. Iwai; A. Inase; S. Jafar; M. Higurashi; T. Ohtsuki; Y. Xu; H. Sugiyama
        Nucleic acids research. Supplement (2001), 2003, Peer-reviewed
      • A nanothermometer based on the different pi stackings of B- and Z-DNA
        R Tashiro; H Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed
      • Deglyco-peplomycin metal complexes on DNA fibers: a role of the sugar moiety for the stability and the orientation of the complexes
        T Iiyama; M Chikira; T Oyoshi; H Sugiyama
        JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, Jan. 2003, Peer-reviewed
      • Molecular design of hairpin pyrrole-imidazole polyamides possessing sequence specific DNA alkylating moiety.
        Narita A; Bando T; Sugiyama H
        Nucleic acids research. Supplement (2001), 2003, Peer-reviewed
      • The conformational study of two carbocyclic nucleosides: Why carbocyclic nucleic acids (CarNAs) form more stable duplexes with RNA than DNA does
        Y Xu; K Kino; H Sugiyama
        JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Dec. 2002, Peer-reviewed
      • Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation
        T Bando; A Narita; Saito, I; H Sugiyama
        CHEMISTRY-A EUROPEAN JOURNAL, Oct. 2002, Peer-reviewed
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      • Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates
        K Fujimoto; H Iida; M Kawakami; T Bando; ZF Tao; H Sugiyama
        NUCLEIC ACIDS RESEARCH, Sep. 2002, Peer-reviewed
      • Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein
        Miyabe, I; QM Zhang; K Kino; H Sugiyama; M Takao; A Yasui; S Yonei
        NUCLEIC ACIDS RESEARCH, Aug. 2002, Peer-reviewed
      • Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein
        K Hashiguchi; QM Zhang; H Sugiyama; S Ikeda; S Yonei
        INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Jul. 2002, Peer-reviewed
      • Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: The protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5 ' side
        T Oyoshi; AHJ Wang; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2002, Peer-reviewed
      • Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: The protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5 ' side
        T Oyoshi; AHJ Wang; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2002, Peer-reviewed
      • Molecular design of hairpin polyamide possessing sequence-specific alkylation activity.
        A. Narita; T. Bando; H. Sugiyama
        Nucleic Acids Res Suppl, 2002, Peer-reviewed
      • Regulation of gene expression by sequence-specific alkylating polyamide.
        T. Oyoshi; W. Kawakami; T. Bando; A. Narita; H. Sugiyama
        Nucleic Acids Res Suppl, 2002, Peer-reviewed
      • A third arm on the chest: Implications for the cortical reorganization theory of phantom limbs [8]
        Yu Sakagami; Toshiya Murai; Hiroshi Sugiyama
        Journal of Neuropsychiatry and Clinical Neurosciences, 2002, Peer-reviewed
      • Photoreactivity of 5-iodouracil-containing DNA-Z  complex
        T. Oyoshi; H. Sugiyama
        Nucleic Acids Symposium Series, 01 Nov. 2001
      • 出芽酵母粗抽出液からの8-oxoG結合活性の検出
        橋口 一成; 張 秋梅; 杉山 弘; 米井 脩治
        日本放射線影響学会大会講演要旨集, Oct. 2001
      • Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides
        T Fujiwara; M Kimoto; H Sugiyama; Hirao, I; S Yokoyama
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2001, Peer-reviewed
      • Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders
        PG Baraldi; G Balboni; MG Pavani; G Spalluto; MA Tabrizi; E De Clercq; J Balzarini; T Bando; H Sugiyama; R Romagnoli
        JOURNAL OF MEDICINAL CHEMISTRY, Aug. 2001, Peer-reviewed
      • Sequence-specific DNA interstrand cross-linking by imidazole-pyrrole CPI conjugate
        T Bando; H Iida; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2001, Peer-reviewed
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      • Possible cause of G center dot C -> C center dot G transversion mutation by guanine oxidation product, imidazolone
        K Kino; H Sugiyama
        CHEMISTRY & BIOLOGY, Apr. 2001, Peer-reviewed
      • Amplification of bleomycin-induced DNA cleavage at cytosine residues 3 ' to GGG sequences by pyrrole triamide
        Y Hiraku; S Oikawa; K Kuroki; H Sugiyama; Saito, I; S Kawanishi
        BIOCHEMICAL PHARMACOLOGY, Feb. 2001, Peer-reviewed
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      • Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli
        Miyabe, I; QM Zhang; H Sugiyama; K Kino; S Yonei
        INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Jan. 2001, Peer-reviewed
      • Identification of repair enzymes for 5-formyluracil in DNA - Nth, Nei, and MutM proteins of Escherichia coli
        QM Zhang; Miyabe, I; Y Matsumoto; K Kino; H Sugiyama; S Yonei
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2000, Peer-reviewed
      • Recognition of DNA sequences by pyrrole-imidazole polyamide: Rational drug design in the post-genome era
        H Iida; H Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Oct. 2000, Peer-reviewed
      • Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations
        S Kawanishi; S Oikawa; M Kawanishi; H Sugiyama; Saito, I; L Strekowski; WD Wilson
        BIOCHEMISTRY, Oct. 2000, Peer-reviewed
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      • Mechanism of DNA strand scission induced by (1,10-phenanthroline)copper complex: Major direct DNA cleavage is not through 1 ',2 '-dehydronucleotide intermediate nor beta-elimination of forming ribonolactone
        T Oyoshi; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2000, Peer-reviewed
      • Metallo-bleomycin cleaves parallel-stranded DNA similarly to B-DNA
        S Ikeda; Saito, I; H Sugiyama
        TETRAHEDRON LETTERS, May 2000, Peer-reviewed
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      • Enhanced cytotoxicity in a Z-photoisomer of a benzopyran derivative of propolis
        M Hirota; T Matsuno; T Fujiwara; H Sugiyama; S Mineshita
        JOURNAL OF NATURAL PRODUCTS, Mar. 2000, Peer-reviewed
      • Highly cooperative DNA dialkylation by the homodimer of imidazole-pyrrole diamide-CPI conjugate with vinyl linker
        ZF Tao; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2000, Peer-reviewed
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      • Imidazole-imidazole pair as a minor groove recognition motif for T : G mismatched base pairs
        XL Yang; RB Hubbard; M Lee; ZF Tao; H Sugiyama; AHJ Wang
        NUCLEIC ACIDS RESEARCH, Nov. 1999, Peer-reviewed
      • State transitions by molecules
        K Sakamoto; D Kiga; K Komiya; H Gouzu; S Yokoyama; S Ikeda; H Sugiyama; M Hagiya
        BIOSYSTEMS, Oct. 1999, Peer-reviewed
      • Modulation of sequence specificity of duocarmycin-dependent DNA alkylation by pyrrole-imidazole triamides
        T Fujiwara; ZF Tao; Y Ozeki; Saito, I; AHJ Wang; M Lee; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1999, Peer-reviewed
      • Substrate recognition by Escherichia coli MutY using substrate analogs
        CL Chepanoske; SL Porello; T Fujiwara; H Sugiyama; SS David
        NUCLEIC ACIDS RESEARCH, Aug. 1999, Peer-reviewed
      • Photochemical halogen-exchange reaction of 5-iodouracil-containing oligonucleotides
        Kiyohiko Kawai; Isao Saito; Hiroshi Sugiyama
        Tetrahedron Letters, 30 Jul. 1999, Peer-reviewed
      • Rational design of sequence-specific DNA alkylating agents based on duocarmycin A and pyrrole-imidazole hairpin polyamides
        ZF Tao; T Fujiwara; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1999, Peer-reviewed
      • Intrastrand 2 'beta hydrogen abstraction of 5 '-adjacent deoxyguanosine by deoxyuridin-5-yl in Z-form DNA
        K Kawai; Saito, I; E Kawashima; Y Ishido; H Sugiyama
        TETRAHEDRON LETTERS, Mar. 1999, Peer-reviewed
      • Conformation-dependent photochemistry of 5-halouracil-containing DNA: Stereospecific 2 'alpha-hydroxylation of deoxyribose in Z-form DNA
        K Kawai; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 1999, Peer-reviewed
      • Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides
        QM Zhang; H Sugiyama; Miyabe, I; S Matsuda; K Kino; Saito, I; S Yonei
        INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Jan. 1999, Peer-reviewed
      • Sequence-specific DNA alkylation by hybrid molecules between segment a of duocarmycin A and pyrrole/imidazole diamide
        ZF Tao; T Fujiwara; Saito, I; H Sugiyama
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1999, Peer-reviewed
      • Sequence-specific alkylation of DNA by duocarmycin A and its novel derivatives bearing PY/IM polyamides
        ZF Tao; T Fujiwara; Saito, I; H Sugiyama
        NUCLEOSIDES & NUCLEOTIDES, 1999, Peer-reviewed
      • Mapping of the hot spots for DNA damage by one-electron oxidation: Efficacy of GG doublets and GGG triplets as a trap in long-range hole migration
        Saito, I; T Nakamura; K Nakatani; Y Yoshioka; K Yamaguchi; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 1998, Peer-reviewed
      • Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine : cytosine and isocytosine : guanine basepairs by nuclear magnetic resonance spectroscopy
        XL Yang; H Sugiyama; S Ikeda; Saito, I; AHJ Wang
        BIOPHYSICAL JOURNAL, Sep. 1998, Peer-reviewed
      • Facile synthesis of puromycin-tethered oligonucleotides at the 3 '-end
        S Ikeda; Saito, I; H Sugiyama
        TETRAHEDRON LETTERS, Aug. 1998, Peer-reviewed
      • Stabilization of Hoogsteen base pairing by introduction of NH2 group at the C8 position of adenine
        Kiyohiko Kawai; Isao Saito; Hiroshi Sugiyama
        Tetrahedron Letters, 16 Jul. 1998, Peer-reviewed
      • Sequence dependent photoreduction of 5-bromouracil-containing oligonucleotides via electron transfer
        Kenzo Fujimoto; Hiroshi Sugiyama; Isao Saito
        Tetrahedron Letters, Apr. 1998, Peer-reviewed
      • Molecular mechanism of GG-specific photooxidation of DNA
        Katsuhito Kino; Hiroshi Sugiyama
        Journal of Medical and Dental Sciences, 1998, Peer-reviewed
      • Preferential C1' hydrogen abstraction by a uracilyl radical in a DNA-RNA hybrid
        H Sugiyama; K Fujimoto; Saito, I
        TETRAHEDRON LETTERS, Nov. 1997, Peer-reviewed
      • Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA
        QM Zhang; H Sugiyama; Miyabe, I; S Matsuda; Saito, I; S Yonei
        NUCLEIC ACIDS RESEARCH, Oct. 1997, Peer-reviewed
      • Interactions of deglycosylated cobalt(III) - Pepleomycin (green form) with DNA based on NMR structural studies
        J CaceresCortes; H Sugiyama; K Ikudome; Saito, I; AHJ Wang
        BIOCHEMISTRY, Aug. 1997, Peer-reviewed
      • Design of photochemical DNA-cleaving molecules via electron transfer
        Saito, I; M Takayama; H Sugiyama; T Nakamura
        JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, Jun. 1997, Peer-reviewed
      • Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies
        J CaceresCortes; H Sugiyama; K Ikudome; Saito, I; AHJ Wang
        EUROPEAN JOURNAL OF BIOCHEMISTRY, Mar. 1997, Peer-reviewed
      • New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior
        H Sugiyama; S Matsuda; K Kino; QM Zhang; S Yonei; Saito, I
        TETRAHEDRON LETTERS, Dec. 1996, Peer-reviewed
      • Remarkably stable parallel-stranded oligonucleotides containing 5-methylisocytosine and isoguanine
        H Sugiyama; S Ikeda; Saito, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 1996, Peer-reviewed
      • Catalytic activities of hammerhead ribozymes with a triterpenoid linker instead of stem/loop II
        H Sugiyama; K Hatano; Saito, I; S Amontov; K Taira
        FEBS LETTERS, Sep. 1996, Peer-reviewed
      • Theoretical studies of GC-specific photocleavage of DNA via electron transfer: Significant lowering of ionization potential and 5'-localization of HOMO of stacked GG bases in B-form DNA
        H Sugiyama; Saito, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 1996, Peer-reviewed
      • Synthesis, structure and thermodynamic properties of 8-methylguanine-containing oligonucleotides: Z-DNA under physiological salt conditions
        H Sugiyama; K Kawai; A Matsunaga; K Fujimoto; Saito, I; H Robinson; AHJ Wang
        NUCLEIC ACIDS RESEARCH, Apr. 1996, Peer-reviewed
      • Evidence for intrastrand C2' hydrogen abstraction in photoirradiation of 5-halouracil-containing oligonucleotides by using stereospecifically C2'-deuterated deoxyadenosine
        H Sugiyama; K Fujimoto; Saito, I
        TETRAHEDRON LETTERS, Mar. 1996, Peer-reviewed
      • Design of photoactivatable DNA-cleaving amino acids with high sequence selectivity - Guanine-guanine stacking rule for electron-transfer from DNA
        Saito, I; M Takayama; H Sugiyama; T Nakamura
        DNA AND RNA CLEAVERS AND CHEMOTHERAPY OF CANCER AND VIRAL DISEASES, 1996, Peer-reviewed
      • STEREOSPECIFIC 1,2-HYDRIDE SHIFT IN RIBONOLACTONE FORMATION IN THE PHOTOREACTION OF 2'-IODODEOXYURIDINE
        H SUGIYAMA; K FUJIMOTO; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1995, Peer-reviewed
      • Mechanism of oxidative DNA strand scission
        H. Sugiyama
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1995, Peer-reviewed
      • NMR characterization of guanine DNA site alkylated by kapurimycin A3, an antitumour antibiotic from Streptomyces sp.
        K. L. Chan; H. Sugiyama; I. Saito; M. Hara
        Phytochemistry, 1995, Peer-reviewed
      • OLIGONUCLEOTIDES CONTAINING A RADICAL TRAP - THE TRAPPING OF DEOXYRIBOSE C4' RADICAL IN BLEOMYCIN-MEDIATED REACTIONS
        H SUGIYAMA; K OHMORI; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 1994, Peer-reviewed
      • ACTIVATION OF NEOCARZINOSTATIN-CHROMOPHORE BY 4-HYDROXYTHIOPHENOL - INTRAMOLECULAR RADICAL TRAPPING OF BIRADICAL INTERMEDIATE
        H SUGIYAMA; T FUJIWARA; SAITO, I
        TETRAHEDRON LETTERS, Nov. 1994, Peer-reviewed
      • CHEMISTRY OF THERMAL-DEGRADATION OF ABASIC SITES IN DNA - MECHANISTIC INVESTIGATION ON THERMAL DNA STRAND CLEAVAGE OF ALKYLATED DNA
        H SUGIYAMA; T FUJIWARA; A URA; T TASHIRO; K YAMAMOTO; S KAWANISHI; SAITO, I
        CHEMICAL RESEARCH IN TOXICOLOGY, Sep. 1994, Peer-reviewed
      • APOPROTEIN-ASSISTED UNUSUAL CYCLIZATION OF NEOCARZINOSTATIN CHROMOPHORE
        H SUGIYAMA; K YAMASHITA; T FUJIWARA; SAITO, I
        TETRAHEDRON, Jan. 1994, Peer-reviewed
      • THE SCID MUTATION IN MICE CAUSES DEFECTS IN THE REPAIR SYSTEM FOR BOTH DOUBLE-STRAND DNA BREAKS AND DNA CROSS-LINKS
        T TANAKA; T YAMAGAMI; Y OKA; T NOMURA; H SUGIYAMA
        MUTATION RESEARCH, Aug. 1993, Peer-reviewed
      • PHOTOINDUCED DEOXYRIBOSE-C2' OXIDATION IN DNA - ALKALI-DEPENDENT CLEAVAGE OF ERYTHROSE-CONTAINING SITES VIA A RETROALDOL REACTION
        H SUGIYAMA; Y TSUTSUMI; K FUJIMOTO; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1993, Peer-reviewed
      • A NOVEL GUANINE N3 ALKYLATION BY ANTITUMOR ANTIBIOTIC DUOCARMYCIN-A
        H SUGIYAMA; K OHMORI; KL CHAN; M HOSODA; A ASAI; H SAITO; SAITO, I
        TETRAHEDRON LETTERS, Mar. 1993, Peer-reviewed
      • CONCERTED DNA RECOGNITION AND NOVEL SITE-SPECIFIC ALKYLATION BY DUOCARMYCIN-A WITH DISTAMYCIN-A
        K YAMAMOTO; H SUGIYAMA; S KAWANISHI
        BIOCHEMISTRY, Feb. 1993, Peer-reviewed
      • PHOTOCHEMISTRY OF 5-HALOURACIL-CONTAINING DNA
        H SUGIYAMA; Y TSUTSUMI; E YAMAGUCHI; SAITO, I
        FRONTIERS OF PHOTOBIOLOGY, 1993, Peer-reviewed
      • 6-ALPHA-HYDROXYEURYCOMALACTONE, A QUASSINOID FROM EURYCOMA-LONGIFOLIA
        KL CHAN; Y IITAKA; H NOGUCHI; H SUGIYAMA; SAITO, I; U SANKAWA
        PHYTOCHEMISTRY, Dec. 1992, Peer-reviewed
      • CHEMISTRY OF NEOCARZINOSTATIN-MEDIATED CLEAVAGE OF OLIGONUCLEOTIDES - COMPETITIVE RIBOSE C5' AND C4' HYDROXYLATION
        H SUGIYAMA; T FUJIWARA; H KAWABATA; N YODA; N HIRAYAMA; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 1992, Peer-reviewed
      • ANTISCHISTOSOMAL ACTIVITIES OF SESQUITERPENE LACTONES AND STEROID GLUCOSIDES FROM VERNONIA-AMYGDALINA, POSSIBLY USED BY WILD CHIMPANZEES AGAINST PARASITE-RELATED DISEASES
        M JISAKA; M KAWANAKA; H SUGIYAMA; K TAKEGAWA; MA HUFFMAN; H OHIGASHI; K KOSHIMIZU
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 1992, Peer-reviewed
      • A NOVEL CYCLIZATION PATHWAY IN ACTIVATION OF NEOCARZINOSTATIN CHROMOPHORE BY THIOL UNDER PHYSIOLOGICAL CONDITIONS
        H SUGIYAMA; K YAMASHITA; M NISHI; SAITO, I
        TETRAHEDRON LETTERS, Jan. 1992, Peer-reviewed
      • DNA cleavage reaction of antitumour antibiotic, kapurimycin A3, with deoxytetranucleotide d(CGCG)2
        Kit Lam Chan; Hiroshi Sugiyama; Isao Saito; Mitsunobu Hara
        Tetrahedron Letters, 23 Dec. 1991, Peer-reviewed
      • BIS(HYDROPEROXY)NAPHTHALDIIMIDE AS A PHOTO-FENTON REAGENT - SEQUENCE-SPECIFIC PHOTOCLEAVAGE OF DNA
        S MATSUGO; S KAWANISHI; K YAMAMOTO; H SUGIYAMA; T MATSUURA; SAITO, I
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, Oct. 1991, Peer-reviewed
      • BLEOMYCIN-MEDIATED DEGRADATION OF ARISTEROMYCIN-CONTAINING DNA - NOVEL DEHYDROGENATION ACTIVITY OF IRON(II) BLEOMYCIN
        H SUGIYAMA; T SERA; Y DANNOUE; R MARUMOTO; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1991, Peer-reviewed
      • HIGHLY SEQUENCE SELECTIVE PHOTOREACTION OF 5-BROMOURACIL-CONTAINING DEOXYHEXANUCLEOTIDES
        H SUGIYAMA; Y TSUTSUMI; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1990, Peer-reviewed
      • SPECIFIC DETECTION OF C-4' HYDROXYLATED ABASIC SITES GENERATED BY BLEOMYCIN AND NEOCARZINOSTATIN IN DNA
        H SUGIYAMA; H KAWABATA; T FUJIWARA; Y DANNOUE; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1990, Peer-reviewed
      • COVALENT ALKYLATION OF DNA WITH DUOCARMYCIN-A - IDENTIFICATION OF ABASIC SITE STRUCTURE
        H SUGIYAMA; M HOSODA; SAITO, I; A ASAI; H SAITO
        TETRAHEDRON LETTERS, 1990, Peer-reviewed
      • ANNEALING EFFECT ON LATTICE DISTORTION IN ANODIZED POROUS SILICON LAYERS
        H SUGIYAMA; O NITTONO
        JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS, Nov. 1989, Peer-reviewed
      • A NOVEL RIBOSE C-4' HYDROXYLATION PATHWAY IN NEOCARZINOSTATIN-MEDIATED DEGRADATION OF OLIGONUCLEOTIDES
        SAITO, I; H KAWABATA; T FUJIWARA; H SUGIYAMA; T MATSUURA
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 1989, Peer-reviewed
      • SYNTHETIC COBALT BLEOMYCIN MODELS AS A PHOTOCHEMICAL DNA CLEAVER
        SAITO, I; T MORII; T OBAYASHI; T SERA; H SUGIYAMA; T MATSUURA
        JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, Mar. 1989, Peer-reviewed
      • PHOTOINDUCED DNA STRAND SCISSION BY COBALT BLEOMYCIN GREEN COMPLEX
        SAITO, I; T MORII; H SUGIYAMA; T MATSUURA; CF MEARES; SM HECHT
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1989, Peer-reviewed
      • OXIDATIVE STRAND SCISSION OF DNA
        T MATSUURA; SAITO, I; H SUGIYAMA; T MORII; H KAWABATA
        PURE AND APPLIED CHEMISTRY, Mar. 1989, Peer-reviewed
      • CHARACTERIZATION OF POROUS SILICON LAYERS BY MEANS OF X-RAY DOUBLE-CRYSTAL DIFFRACTOMETRY
        H SUGIYAMA; O NITTONO
        ISIJ INTERNATIONAL, 1989, Peer-reviewed
      • METALLO-BLEOMYCIN-MEDIATED DEGRADATION OF DEOXYTETRANUCLEOTIDES - UNUSUAL C-4' HYDROXYLATION AT TERMINAL CYTIDINE
        H SUGIYAMA; T TASHIRO; Y DANNOUE; T MIWA; T MATSUURA; SAITO, I
        TETRAHEDRON LETTERS, 1989, Peer-reviewed
      • CHEMISTRY OF NEOCARZINOSTATIN-MEDIATED DEGRADATION OF D(GCATGC) - MECHANISM OF SPONTANEOUS THYMINE RELEASE
        H KAWABATA; H TAKESHITA; T FUJIWARA; H SUGIYAMA; T MATSUURA; SAITO, I
        TETRAHEDRON LETTERS, 1989, Peer-reviewed
      • EXCITED-STATE BEHAVIOR OF TRYPTAMINE AND RELATED INDOLES - REMARKABLY EFFICIENT INTRAMOLECULAR PROTON-INDUCED QUENCHING
        H SHIZUKA; M SERIZAWA; H KOBAYASHI; K KAMETA; H SUGIYAMA; T MATSUURA; SAITO, I
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1988, Peer-reviewed
      • CHEMISTRY OF THE ALKALI-LABILE LESION FORMED FROM IRON(II) BLEOMYCIN AND D(CGCTTTAAAGCG)
        H SUGIYAMA; C XU; N MURUGESAN; SM HECHT; GA VANDERMAREL; JH VANBOOM
        BIOCHEMISTRY, Jan. 1988, Peer-reviewed
      • COPPER-DEPENDENT CLEAVAGE OF DNA BY BLEOMYCIN
        GM EHRENFELD; JB SHIPLEY; DC HEIMBROOK; H SUGIYAMA; EC LONG; JH VANBOOM; GA VANDERMAREL; NJ OPPENHEIMER; SM HECHT
        BIOCHEMISTRY, Feb. 1987, Peer-reviewed
      • DNA STRAND SCISSION BY BLEOMYCIN - CATALYTIC CLEAVAGE AND STRAND SELECTIVITY
        H SUGIYAMA; RE KILKUSKIE; LH CHANG; LT MA; SM HECHT; GA VANDERMAREL; JH VANBOOM
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1986, Peer-reviewed
      • PERIODIC ACID-SCHIFF (PAS)-POSITIVE, ANTIGRANULOCYTES STRUCTURES INCREASE IN THE BRAIN OF SENESCENCE ACCELERATED MOUSE (SAM)
        H AKIYAMA; M KAMEYAMA; AKIGUCHI, I; H SUGIYAMA; T KAWAMATA; H FUKUYAMA; H KIMURA; M MATSUSHITA; T TAKEDA
        ACTA NEUROPATHOLOGICA, 1986, Peer-reviewed
      • DNA STRAND SCISSION BY BLEOMYCIN GROUP ANTIBIOTICS
        H SUGIYAMA; GM EHRENFELD; JB SHIPLEY; RE KILKUSKIE; LH CHANG; SM HECHT
        JOURNAL OF NATURAL PRODUCTS, Nov. 1985, Peer-reviewed
      • STACKING INTERACTION BETWEEN TRYPTOPHAN AND URACIL IN A SYNTHETIC MODEL-COMPOUND
        SAITO, I; H SUGIYAMA; T MATSUURA; K FUKUYAMA
        TETRAHEDRON LETTERS, 1985, Peer-reviewed
      • AN EFFICIENT, SITE-SPECIFIC DNA TARGET FOR BLEOMYCIN
        H SUGIYAMA; RE KILKUSKIE; SM HECHT; GA VANDERMAREL; JH VANBOOM
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, Peer-reviewed
      • PHOTOINDUCED REACTIONS .165. REGIO-CONTROLLED HYDROGEN-DEUTERIUM EXCHANGE OF BIOLOGICALLY IMPORTANT INDOLES UNDER UV IRRADIATION
        SAITO, I; S MURAMATSU; H SUGIYAMA; A YAMAMOTO; T MATSUURA
        TETRAHEDRON LETTERS, 1985, Peer-reviewed
      • ANALYSIS OF PRODUCTS FORMED DURING BLEOMYCIN-MEDIATED DNA-DEGRADATION
        N MURUGESAN; C XU; GM EHRENFELD; H SUGIYAMA; RE KILKUSKIE; LO RODRIGUEZ; LH CHANG; SM HECHT
        BIOCHEMISTRY, 1985, Peer-reviewed
      • STRUCTURE OF THE ALKALI-LABILE PRODUCT FORMED DURING IRON(II)-BLEOMYCIN-MEDIATED DNA STRAND SCISSION
        H SUGIYAMA; C XU; N MURUGESAN; SM HECHT
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, Peer-reviewed
      • A NEW PROCEDURE FOR DETERMINING THYMINE RESIDUES IN DNA SEQUENCING - PHOTOINDUCED CLEAVAGE OF DNA FRAGMENTS IN THE PRESENCE OF SPERMINE
        SAITO, I; H SUGIYAMA; T MATSUURA; K UEDA; T KOMANO
        NUCLEIC ACIDS RESEARCH, 1984, Peer-reviewed
      • PHOTOINDUCED REACTIONS .159. PHOTOCHEMICAL-REACTION BETWEEN TRYPTOPHAN AND THYMINE
        SAITO, I; H SUGIYAMA; T MATSUURA; K FUKUYAMA; Y KATSUBE
        TETRAHEDRON LETTERS, 1984, Peer-reviewed
      • PHOTOCHEMICAL HYDROGEN-DEUTERIUM EXCHANGE-REACTION OF TRYPTOPHAN - THE ROLE IN NONRADIATIVE DECAY OF SINGLET TRYPTOPHAN
        SAITO, I; H SUGIYAMA; A YAMAMOTO; S MURAMATSU; T MATSUURA
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, Peer-reviewed
      • PHOTOINDUCED REACTIONS .151. ISOLATION AND CHARACTERIZATION OF A THYMINE-LYSINE ADDUCT IN UV-IRRADIATED NUCLEI - THE ROLE OF THYMINE LYSINE PHOTOADDITION IN PHOTO-CROSS-LINKING OF PROTEINS TO DNA
        SAITO, I; H SUGIYAMA; T MATSUURA
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed
      • PHOTOREACTION OF THYMIDINE WITH ALKYLAMINES - APPLICATION TO SELECTIVE REMOVAL OF THYMINE FROM DNA
        SAITO, I; H SUGIYAMA; T MATSUURA
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, Peer-reviewed
      • PHOTOINDUCED REACTIONS .133. PHOTOCHEMICAL RING-OPENING OF THYMIDINE AND THYMINE IN THE PRESENCE OF PRIMARY AMINES
        SAITO, I; H SUGIYAMA; N FURUKAWA; T MATSUURA
        TETRAHEDRON LETTERS, 1981, Peer-reviewed
      • PHOTOINDUCED REACTIONS .130. A NOVEL PHOTOREACTION OF THYMIDINE WITH - PHOTOINDUCED MIGRATION OF THYMINE FROM DNA TO LYSINE
        SAITO, I; H SUGIYAMA; S ITO; N FURUKAWA; T MATSUURA
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, Peer-reviewed
      • ELECTROORGANIC CHEMISTRY .49. ELECTROREDUCTIVE HYDROCOUPLING OF ACTIVATED OLEFINS WITH KETONES OR ALDEHYDES IN THE PRESENCE OF TRIMETHYLCHLOROSILANE
        T SHONO; H OHMIZU; S KAWAKAMI; H SUGIYAMA
        TETRAHEDRON LETTERS, 1980, Peer-reviewed
      • ORGANIC-CHEMICAL APPROACH TO PHOTO-CROSS-LINKS OF NUCLEIC-ACIDS TO PROTEINS
        T MATSUURA; SAITO, I; S ITO; H SUGIYAMA; T SHINMURA
        PURE AND APPLIED CHEMISTRY, 1980, Peer-reviewed
      • Photochemical reaction of 8-azaxanthine with nucleophiles
        I. Saito; S. Ito; H. Sugiyama; M. Akita; T. Matsuura
        Tetrahedron Letters, 1979, Peer-reviewed
      • Elastic properties of (NH4)2SO4 in the paraelectrlc region
        N. Nakanishi; Y. Murakami; M. Tobioka; H. Sugiyama; S. Kachi
        Journal of the Physical Society of Japan, 1973, Peer-reviewed
      • Syntheses and reactions of deuterated troponoids
        S. Ito; J. Tsunetsugu; T. Kanno; H. Sugiyama; H. Takeshita
        Tetrahedron Letters, 1966, Peer-reviewed

      Misc.

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        Vinodh J. Sahayasheela; 杉山 弘
        化学 = Chemistry, Apr. 2023
      • 急性骨髄性白血病およびT細胞性免疫の新規治療標的としてのRUNX-NFATアキシス
        増田 達哉; 窪田 博仁; 櫻本 直也; 秦 明日香; 堀内 彩香; 佐々木 亜沙美; 武田 佳那子; 武田 瑞穂; 松尾 英将; 杉山 弘; 足立 壮一; 上久保 靖彦
        日本癌学会総会記事, Oct. 2020
      • PNA-ポリアミド複合体による二本鎖DNAの所定位置の認識
        亀島渡; 石塚匠; 蓑島維文; XU Yan; 杉山弘; 小宮山眞
        日本化学会講演予稿集, 2010
      • 大腸菌DNAポリメラーゼIIIによる酸化的損傷ヌクレオチドの取り込み
        清水雅富; 清水雅富; GRUZ Petr; 藤井慎吾; 紙谷浩之; XU Yan; 碓井之雄; 杉山弘; 原島秀吉; FUCHS Robert P; 能美健彦
        生化学, 2007
      • ヒトYファミリーDNAポリメラーゼによる酸化的損傷ヌクレオチドの取り込み
        清水雅富; GRUZ P; 紙谷浩之; 益谷央豪; XU Y; 杉山弘; 原島秀吉; 花岡文雄; 能美健彦
        日本分子生物学会年会プログラム・講演要旨集, 2003
      • Photoreaction of DNA Containing 5-Halouracil and its Products†
        Ryu Tashiro; Hiroshi Sugiyama
        Photochemistry and Photobiology, 2021
      • Sequence-specific PI polyamides make it possible to regulate DNA structure and function
        Toshikazu Bando; Hiroshi Sugiyama
        Bulletin of the Chemical Society of Japan, 01 Feb. 2020
      • AMLおよびGVHDの新しい治療標的としてのRUNX-NFAT軸の重要性(The importance of RUNX-NFAT axis as a novel therapeutic target for AML and GVHD)
        増田 達哉; 窪田 博仁; 櫻本 直也; 秦 明日香; 堀内 彩香; 佐々木 亜沙美; 武田 佳那子; 武田 瑞穂; 松尾 英将; 平田 勝啓; 今井 陽一; 中畑 龍俊; 滝田 順子; 杉山 弘; 足立 壯一; 上久保 靖彦
        日本血液学会学術集会, Sep. 2021
      • 薬剤耐性APL新規治療標的としてのRUNX1-NFATc2 axis(Identification of RUNX1-NFATc2 axis as a novel target for overcoming drug-resistant APL)
        立田 俊也; 古市 華菜; 増田 達哉; 窪田 博仁; 岩井 篤; 三上 真充; 服部 悦子; 松尾 英将; 杉山 弘; 足立 壮一; 上久保 靖彦
        日本癌学会総会記事, Sep. 2019
      • CROX:(Cluster Regulation of RUNX)による新規急性骨髄性白血病制御戦略の提唱
        野口勇貴; 能浦三奈; 岩井詩咲花; 嶌田紗英; 鈴木雄太; 鈴木雄太; 杉山弘; 足立壮一; 上久保靖彦
        日本小児血液・がん学会雑誌(Web), 2018
      • Regulation of B-Z Transition by Introduction of 8-Methyldeoxyguanosine.
        川井清彦; 藤本健造; 松永篤; 杉山弘; 斎藤烈
        日本化学会講演予稿集, 1995
      • Photoreactivity of BrU-Conaining Oligonucleotides in Z-form.
        川井清彦; 藤本健造; 杉山弘; 斎藤烈
        日本化学会講演予稿集, 1996
      • Synthesis of Oligonucleotides Containing 8-Methyldeoxyguanosine and Their Photoreactivity.
        杉山弘; 藤本健造; 松永篤; 川井清彦; 斎藤烈
        日本化学会講演予稿集, 1994
      • 102 Purification and Characterization of Schizosaccharomyces pombe Nth Homologue(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :
        YONEKURA ShinIchiro; ZHANG Qiu Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2003
      • Identification of Human Nei Protein as a 5-Formyluracil DNA Glycosylase/AP lyase :
        ZHANG Qiu-Mei; TAKAO Masashi; SUGIYAMA Hiroshi; YASUI Akira; YONEI Shuji
        Journal of radiation research, 2002
      • The chemical biology of the DNA binding polyamides
        BANDO Toshikazu; SUGIYAMA Hiroshi
        Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011
      • Guanine oxidation product, 2-aminoimidazolone, may cause G:C->C:G transversion mutation
        KINO Katsuhito; SUGIYAMA Hiroshi
        Photomedicine and photobiology, 04 Aug. 2000
      • Molecular Design of Effective Sequence-specific DNA Alkylating Agents using Pyrrole-Imidazole Polyamides
        Bando Toshikazu; Sugiyama Hiroshi
        Reports of the Institute of Biomaterials and Bioengineering, 2003
      • Identification of a DNA Glycosylase Activity of Human hNTH1 Protein Acting on 5-Formyluracil, a Major Oxidative Lesion of Thymine :
        MIYABE Izumi; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; KINO Katsuhito; TAKAO Masashi; YASUI Akira; YONEI Shuji
        Journal of radiation research, 2000
      • Identification of Repair Enzymes for 5-Formyluracil in DNA : Endonuclease III, Endonuclease VIII and MutM Proteins of Escherichia coli :
        ZHANG Qiu-Mei; MIYABE Izumi; MATSUMOTO Yukiko; SUGIYAMA Hiroshi; KINO Katsuhito; YONEI Shuji
        Journal of radiation research, 2000
      • Purification and Characterization of 5-Formyluracil DNA Glycosylase from Human Cells in Culture :
        ZHANG Qiu-Mei; MATSUMOTO Yukiko; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 1999
      • 5-Formyluracil, a Major Product of Thymine Oxidation, Induces Base Substitutions and Deletions on a Plasmid Replicated in Escherichia coli :
        MIYABE Izumi; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 1999
      • The Effect of 5-Formyluracil, a Major Oxidative Lesion of Thymine, on Biological Function of DNA in vivo and in vitro :
        MIYABE Izumi; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 1998
      • DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing Oxidized Bases :
        HORI Masaki; ZHANG Qiu-Mei; NOHMI Takehiko; GRUZ Petr; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2002
      • Purification and Characterization of Schizosaccharomyces pombe Nth Homologue :
        YONEKURA Shin-Ichiro; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2002
      • dentification of 5-Formyluracil DNA Glycosylase/AP Lyase Activity of S. cerevisiae Ntg1 and Ntg2 Proteins :
        ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2001
      • Identification of 5-Hydroxymethyluracil-DNA Glycosylase Activities in Extracts from Escherichia coli :
        HORI Masaki; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2001
      • Identification of Binding Activities to 8-Oxoguanine-Containing Oligonucleotides in Extracts Prepared fromSaccharomyces cerevisiae :
        HASHIGUCHI Kazunari; ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 2001
      • The Effect of 5-Formyluracil and 5-Hydroxymethyluracil, a Major Oxidative Lesion of Thymine, on Biological Functions of DNA : The Effect of 5-Formyluracil and 5-Hydroxymethyluracil, a Major Oxidative Lesion of Thymine, on Biological Functions of DNA
        ZHANG Qiu-Mei; MIYABE Izumi; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 1997
      • Replication of DNA Templates Containing the 5-Formyluracil, a Major Oxidative Lesion of Thymine in DNA : Replication of DNA Templates Containing the 5-Formyluracil, a Major Oxidative Lesion of Thymine in DNA
        ZHANG Qiu-Mei; SUGIYAMA Hiroshi; YONEI Shuji
        Journal of radiation research, 1996
      • Suppression of glioblastoma through novel drug based on 'Gene Switch Technology'
        Etsuko Y. Hattori; Yoshiki Arakawa; Youhei Mineharu; Masamitsu Mikami; Yasuzumi Matsui; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        CANCER SCIENCE, Feb. 2021
      • Synthesis of Fluorescent Nucleoside Analogues and their Application as Dual Probes for the Non-canonical DNA Structures
        WEE, Wen, Ann; PARK, Soyoung; YUM, Jihye; HIRASHIMA, Shingo; SUGIYAMA, Hiroshi
        日本化学会第100春季年会，講演予稿集P.56 3E6-20, Mar. 2020, Lead author
      • 逆配向型環状PIP-DNA複合体のX線結晶構造
        安倍 克彦; 廣瀬 優希; 浴 晴彦; 竹田 一旗; 遠藤 政幸; 板東 俊和; 杉山 弘
        日本化学会第100春季年会，講演予稿集P.55 2E6-31, Mar. 2020, Lead author
      • Direct Observation of Nucleosome Interaction in DNA Frame using High-speed AFM
        FENG, Yihong; HIDAKA, Kumi; SUGIYAMA, Hiroshi; ENDO, Masayuki
        日本化学会第100春季年会，講演予稿集P.56 4E6-04, Mar. 2020, Lead author
      • 蛍光性チミン・シトシンを用いた配向依存性を有するFRET系の構築と評価
        平島 眞吾; 朴 昭映; 杉山 弘
        日本化学会第100春季年会，講演予稿集P.56 3E6-19, Mar. 2020, Lead author
      • DNA Quadruplex-Duplex Hybrids as Bimolecular Scaffolds for Asymmetric Catalysis
        YUM, Jihye; PARK, Soyoung; SUGIYAMA, Hiroshi
        日本化学会第100春季年会, 講演予稿集P.55 2E6-25, Mar. 2020, Lead author
      • ピロールイミダゾールポリアミドを用いた塩基配列選択的なミトコンドリアDNA制御
        日高 拓也; Ganesh Pandian; Namasivayam; 板東 俊和; 杉山 弘
        第42回日本分子生物学会年会, Dec. 2019, Lead author
      • ピロールーイミダゾールポリアミドを用いたヒト生細胞におけるテロメアのイメージング
        坪野 友太朗; 日高 拓也; 河本 佑介; Ganesh Pandian; Namasivayam; 板東 俊和; 杉山 弘
        第42回日本分子生物学会年会, Dec. 2019, Lead author
      • DNA Quadruplex-Duplex Hybrids as Bimolecular Scaffolds for Asymmetric Catalysis
        Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Development of New Biohybrid Materials by Merging of DNA and Amino Acids
        Soyoung Park; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Telomere Imaging in Human Live cells with Pyrrole-Imidazole Polyamide
        Yutaro Tsubono; Takuya Hidaka; Yusuke Kawamoto; Kaori Hashiya; Ganesh Pandian Namasivayam; Toshikazu Bando; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Approach to determination of G-quadruplex structure on the Nucleosome Structure using thdG-tC FRET pair
        Ji Hoon Han; Soyoung Park; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Investigation into DNA Binding Orientation of Cyclic Pyrrole-Imidazole Polyamides
        Yuki Hirose; Sefan Asamitsu; Toshikazu Bando; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Construction, Characterization and Application of Histidine-modified G-quadruplex
        Koyuki Fukumoto; Soyoung Park; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Development of FRET System Using Fluorescent Thymine and Cytosine Analogues
        Shingo Hirashima; Ji Hoon Han; Soyoung Park; Hiroshi Sugiyama
        The 46th International Symposium on Nucleic Acids Chemistry (ISNAC 2019), Koganei Civic Center (Miyaji Gakki Hall), Koganei, Tokyo, Japan, Oct. 2019, Lead author
      • Enantioselective Hydration of α,β -unsaturated Ketone Using a DNA Hybrid Catalyst Containing an Intrastrand Bipyridine Ligand
        Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama
        The 2nd JGP Chem&ChemEn International Workshop: Sustainability-Oriented Organic Synthesis, Katsura Hall, Katsura Campus, Kyoto University, Kyoto, Japan, Sep. 2019, Lead author
      • Synthesis and Application of Fluorescent Nucleobase Analogues
        Shingo Hirashima; Ji Hoon Han; Soyoung Park; Hiroshi Sugiyama
        The 2nd JGP Chem&ChemEn International Workshop: Sustainability-Oriented Organic Synthesis, Katsura Hall, Katsura Campus, Kyoto University, Kyoto, Japan, Sep. 2019, Lead author
      • 人工遺伝子スイッチによるエピジェネティック創薬
        杉山 弘
        遺伝子・デリバリー研究会 第19回夏期セミナー（京都）, Sep. 2019, Lead author
      • 遺伝子発現を制御するPIPコンジュゲートの開発
        板東 俊和; 杉山 弘
        第13回バイオ関連化学シンポジウム2019, Sep. 2019, Lead author
      • Synthetic gene switches to regulate liver cell differentiation
        Soumya Sethi; Minh Nguyen Tuyet Le; Kouichi Hasegawa; Ganesh Pandian Namasivayam; Hiroshi Sugiyama
        Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019), Port Island Campus, Konan University, Kobe, Japan, Jul. 2019, Lead author
      • Construction, Characterization and Application of Histidine-modified G-quadruplex
        Soyoung Park; Koyuki Fukumoto; Hiroshi Sugiyama
        Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019), Port Island Campus, Konan University, Kobe, Japan, Jul. 2019, Lead author
      • Investigation of DNA Quadruplex-Duplex Hybrids and Its Application to Asymmetric Synthesis
        Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama
        Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019), Port Island Campus, Konan University, Kobe, Japan, Jul. 2019, Lead author
      • Cooperative DNA recognizing system assisted by orthogonal γPNA dimerization domains
        Zutao Yu; Danith H. Ly; Hiroshi Sugiyama
        Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019), Port Island Campus, Konan University, Kobe, Japan, Jul. 2019, Lead author
      • 環状ピロール−イミダゾールポリアミドの合成と評価
        廣瀬 優希; 朝光 世煌; 板東 俊和; 杉山 弘
        生体機能関連化学部会若手の会 第31回サマースクール, Jul. 2019, Lead author
      • ピロール−イミダゾールポリアミドを用いたテロメアのイメージング
        坪野 友太朗; 日高 拓也; 河本 佑介; Pandian; Ganesh Namasivayam; 板東 俊和; 杉山 弘
        生体機能関連化学部会若手の会 第31回サマースクール, Jul. 2019, Lead author
      • Chemical biology of nucleic acids: DNA origami and artificial genetic switch
        杉山 弘
        リエゾンラボ研究会 HIGO最先端セミナー，熊本大学 発生医学研究所, May 2019, Lead author
      • Development and Application of Fluorescent Nucleoside Analogues
        Shingo Hirashima; Ji Hoon Han; Soyoung Park; Hiroshi Sugiyama
        123rd Korean Chemical Society National Meeting & Exposition, Suwon Convention Center, Suwon, Korea, Apr. 2019, Lead author
      • Direct observation of nucleosome in DNA frame using high-speed AFM
        Y. Feng; K. Hidaka; F. Hashiya; H. Sugiyama; M. Endo
        日本化学会第99春季年会(2019), Mar. 2019
      • Surface Observation of Self-Assembled 3D DNA Crystals by Atomic Force Microscopy
        H. Eki; H. Sugiyama; M. Endo
        The 45th International Symposium on Nucleic Acid Chemistry, Nov. 2018
      • Genetic regulation of RUNX2 induce apoptotic cell death through regulating the expression of SOX2 in CRPC-NE cells
        Yuki Noguchi; Natsuki Wariishi; Shiina Iwai; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Masaya Baba; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo
        CANCER RESEARCH, Jul. 2018
      • 自己集合性3次元DNA結晶のAFMによる結晶表面観察
        浴 晴彦; 杉山 弘; 遠藤 政幸
        日本化学会第98春季年会(2018), Mar. 2018
      • グアニン四重鎖の生物学的意義ーローカル環境が与える影響とエピジェネティクスー
        朝光 世煌; 杉山 弘
        月刊「化学」, 2018, Invited
      • Cell-Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells
        Mina Noura; Ken Morita; Chieko Tokushige; Shintaro Maeda; Hiroki Kiyose; Toshikazu Bando; Kenichi Yoshida; Hidemasa Matsuo; Seishi Ogawa; Paul P. Liu; Hiroshi Sugiyama; Yasuhiko Kamikubo; Souichi Adachi
        BLOOD, Dec. 2017
      • RUNX1 Enhances Leukemia Cell Engraftment in the Vascular Niche through up-Regulating E-Selectin
        Chieko Tokushige; Ken Morita; Shintaro Maeda; Hiroki Kiyose; Mina Noura; Tatsuki Kataoka; Toshikazu Bando; Hiroshi Sugiyama; Yasuhiko Kamikubo; Souichi Adachi
        BLOOD, Dec. 2017
      • Direct observation of photoresponsive DNA nanodevice and its self-assembly
        Y. Kamada; E. Willner; Y. Suzuki; T. Emura; K. Hidaka; H. Dietz; H. Sugiyama; M. Endo
        The 44th International Symposium on Nucleic Acid Chemistry, Nov. 2017
      • Biophysical property of G-quadruplex caged in a confined DNA nanospace
        M. Endo; P. Shrestha; S. Jonchhe; T. Emura; K. Hidaka; H. Sugiyama; H. Mao
        DNA23: The 23rd International Meeting on DNA Computing and Molecular Programming, Sep. 2017, Peer-reviewed
      • DNAのらせん構造に基づくバイオハイブリッド触媒の開発と不斉合成への応用
        朴昭映; 杉山弘
        バイオ・高分子シンポジウム講演要旨集, 20 Jul. 2017
      • RUNX1 positively regulates ErbB2/HER2 signaling pathway through modulating the expression of SOS1 in gastric cancer cells
        Yoshihide Mitsuda; Ken Morita; Shintaro Maeda; Kensho Suzuki; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        CANCER RESEARCH, Jul. 2017
      • 光応答性を持つDNA分子デバイスの構築とその自己集積化
        鎌田 佑; Elena Willner; 鈴木 勇輝; 江村 智子; 日高 久美; Hendrik Dietz; 杉山 弘; 遠藤 政幸
        日本ケミカルバイオロジー学会 第12回年会, Jun. 2017
      • RUNX1 regulates KIT expression and is a novel therapeutic target in human mast-cell diseases.
        Mayu Tokumasu; Tatsuki R. Kataoka; Yuki Noguchi; Ken Morita; Hiroshi Sugiyama; Yasuhiko Kamikubo; Souichi Adachi
        JOURNAL OF IMMUNOLOGY, May 2017
      • Observation of single biomolecule properties in a DNA nanospace
        M. Endo; P. Shrestha; S. Jonchhe; T. Emura; K. Hidaka; H. Sugiyama; H. Mao
        14th Conference on the Foundations of Nanoscience 2017, Snowbird, UT, USA, Apr. 2017
      • コンフォメーション変換により化学反応を誘導するDNAナノ構造体の構築
        鎌田 佑; 竹内 洋祐; 竹中 友洋; 江村 智子; 杉山 弘; 遠藤 政幸
        日本化学会第97春季年会(2017), Mar. 2017
      • DNA鎖の拘束によるCas9切断への影響
        Michael H. Räz; 日高 久美; Shana J. Sturla; 杉山 弘; 遠藤 政幸
        日本化学会第97春季年会(2017), Mar. 2017
      • Chemical Biology which Controls DNA Structure and Function
        Sugiyama Hiroshi
        The Journal of The Japanese Society for Cataract Research, 2017
      • Cluster Regulation of RUNX Family By "Gene Switch" Triggers a Profound Tumor Regression of Diverse Origins
        Ken Morita; Kensho Suzuki; Shintaro Maeda; Yoshihide Mitsuda; Ayaka Yano; Yoshimi Yamada; Hiroki Kiyose; Chieko Tokushige; Paul P. Liu; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo
        BLOOD, Dec. 2016
      • Targeting Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia with a Novel Transcriptional Inhibitor
        Shintaro Maeda; Ken Morita; Kensho Suzuki; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo
        BLOOD, Dec. 2016
      • RNA-DNA Triplex Formation by Long Noncoding RNAs
        Yue Li; Junetha Syed; Hiroshi Sugiyama
        CELL CHEMICAL BIOLOGY, Nov. 2016
        Access this misc :
      • Filling cavities of lipid-bilayer-supported two-dimensional DNA origami arrays
        Y. Suzuki; H. Sugiyama; M. Endo
        DNA22: The Twentieth International Meeting on DNA Computing and Molecular Programming, Ludwig-Maximilians-Universität München, Germany, Sep. 2016, Peer-reviewed
      • Photoregulated DNA-based rotary nanomachine and direct visualization of the rotational movement
        Y. Yang; R. Tashiro; Y. Suzuki; T. Emura; K. Hidaka; H. Sugiyama; M. Endo
        DNA22: The Twentieth International Meeting on DNA Computing and Molecular Programming, Ludwig-Maximilians-Universität München, Germany, Sep. 2016, Peer-reviewed
      • Direct observation of the duplex formation and dissociation in the G-quadruplex-/i-motif-forming site
        M. Endo; X. Xing; X. Zhou; T. Emura; K. Hidaka; B. Tuesuwa; H. Sugiyama
        The 43rd International Symposium on Nucleic Acid Chemistry, Kumamoto, Sep. 2016
      • ATR-X症候群の臨床研究
        和田 敬仁; 塩田 倫史; 福永 浩司; 杉山 弘; 田辺 秀之; 岡本 伸彦; 黒澤 健司; 新保 裕子
        脳と発達, May 2016
      • ケミカルバイオロジーと科研費
        杉山 弘
        有合化, 2016
      • Potential of functional PI polyamide conjugate for nucleic acid medicines
        板東 俊和; 杉山 弘
        バイオサイエンスとインダストリー, 2016
      • DNA origamiを用いたイオンチャネル集積化法の開発
        黒川 竜紀; 清中 茂樹; 中田 栄司; 遠藤 政幸; 小山 祥平; 森 恵美子; 矢野 将太郎; 鈴木 勇輝; 日高 久美; 川田 正晃; 佐藤 主税; 杉山 弘; 森井 孝; 森 泰生
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Single-molecule manipulation and visualization of multiple DNA structural changes in the DNA nanostructures using high-speed AFM
        M. Endo; H. Sugiyama
        2015 International Chemical Congress of Pacific Basin Societies (PacifiChem 2015), Honolulu, HI, Dec. 2015
      • DNA ナノ構造体上での光駆動型DNA モーターの歩行運動の1 分子観察
        遠藤 政幸; 楊 泱泱; Marisa A. Goetzfried; 日高 久美; Mingxu You; Weihong Tan; 杉山 弘
        「細胞を創る」研究会8.0, Nov. 2015
      • 脂質膜‒溶液界面におけるDNA オリガミナノテクノロジー
        鈴木 勇輝; 遠藤 政幸; 杉山 弘
        「細胞を創る」研究会 8.0, Nov. 2015
      • Single-molecule observation of a photo-controlled DNA walker on the DNA origami tile
        Y. Yang; M. A. Goetzfried; K. Hidaka; M. You; W. Tan; H. Sugiyama; M. Endo
        The 42nd International Symposium on Nucleic Acid Chemistry, Himeji, Sep. 2015
      • Direct visualization of a photo-controlled DNA walker on the DNA nanostructure
        M. Endo; Y. Yang; M. Goetzfried; K. Hidaka; M. You; W. Tan; H. Sugiyama
        DNA21: The Twentieth International Meeting on DNA Computing and Molecular Programming, Harvard University, Cambridge, MA, Aug. 2015, Peer-reviewed
      • Direct observation of G-quadruplexes using DNA origami nanoscafiold
        Arivazhagan Rajendran; Yue Li; Masayuki Endo; Hiroshi Sugiyama
        Biological Relevance and Therapeutic Applications of DNA and RNA Quadruplexes, 01 Jul. 2015
      • Direct visualization of the dynamic process of DNA origami assembly on the lipid bilayer surface
        M. Endo; Y, Suzuki; H. Sugiyama
        12th Conference on the Foundations of Nanoscience 2015, Snowbird, UT, USA, Apr. 2015, Peer-reviewed
      • Chemical biology of DNA
        杉山 弘
        生体の科学, Mar. 2015
      • DNA as a Chiral Scaffold for Asymmetric Catalysis
        Soyoung Park; Hiroshi Sugiyama
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Dec. 2014
      • Lipid Bilayer-assisted 2D Crystallization of DNA Origami Nanostructures
        Y. Suzuki; M. Endo; H. Sugiyama
        The 8th International Symposium on NanoBiotechnology, National Center for Nanoscience and Technology, Beijing, Oct. 2014
      • Creation of artificial genetic switch based on epigenetic modification
        谷口 純一; 杉山 弘
        バイオサイエンスとインダストリー, 2014
      • Next Generation Nanosystem Using DNA Origami
        遠藤 政幸; 杉山 弘
        化學工業, Jan. 2014
      • Construction and Characterization of Cy3-or Cy5-Conjugated Hairpin Pyrrole/Imidazole Polyamides Binding to DNA in the Nucleosome
        Yong-Woon Han; Tomoko Matsumoto; Hiroaki Yokota; Yasuo Tsunaka; Gengo Kashiwazaki; Hironobu Morinaga; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Yoshie Harada
        BIOPHYSICAL JOURNAL, Jan. 2014, Peer-reviewed
      • Novel DNA origami tubular structures with variable arrangements
        S. Yamamoto; M. Endo; K. Hidaka; H. Sugiyama
        The 40th International Symposium on Nucleic Acid Chemistry, Yokohama, Nov. 2013, Peer-reviewed
      • Programmed DNA nanostructures: photocontrollable assembly to construct pre-designed multidirectional patterns
        Y. Yang; M. Endo; Y. Suzuki; K. Hidaka; H. Sugiyama
        The 40th International Symposium on Nucleic Acid Chemistry, Yokohama, Nov. 2013, Peer-reviewed
      • DNAオリガミによる生体分子の動的な観察システム
        遠藤 政幸; 杉山 弘
        現代化学, Jul. 2013
      • Single-molecule Analysis Using DNA Origami Nanostructures
        ENDO Masayuki; SUGIYAMA Hiroshi
        Seibutsu Butsuri, 25 May 2013
      • Direct visualization of Cre-loxP site specific recombination using DNA origami scaffold
        Y. Suzuki; Y. Katsuda; K. Ou; K. Hidaka; M. Endo; H. Sugiyama
        10th Conference on the Foundations of Nanoscience 2013, Snowbird, UT, Apr. 2013
      • Photo-functionalization of DNA origami: photo-responsible behavior observation and reversible multi-orientational assembling
        Y. Yang; M. Endo; Y. Suzuki; K. Hidaka; H. Sugiyama
        10th Conference on the Foundations of Nanoscience 2013, Snowbird, UT, Apr. 2013, Peer-reviewed
      • 3SCA-01 Chemical Biology that Controls DNA Structure and Function : DNA Origami and Artificial Genetic Switch(3SCA Frontier of functional nucleic acids toward elucidation of biological events and nucleic acid medicine,Symposium)
        Sugiyama Hiroshi
        Seibutsu Butsuri, 2013
      • Single-molecule observation of enzymes and DNA structural changes in the DNA nanostructures
        Hiroshi Sugiyama; Masayuki Endo
        JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Jan. 2013
      • TARGET EPIGENETIC REGULATION AT A SPECIFIC GENOMIC REGION TO INDUCE STEM CELL LIKE PHENOTYPE IN NEUROBLASTOMA CELLS
        Hiroki Nagase; Takayoshi Watanabe; Nobuko Koshikawa; Toshikazu Bando; Hiroshi Sugiyama
        PEDIATRIC BLOOD & CANCER, Dec. 2012
      • Induction of cell fate change by means of artificial regulation of target genome histone acetylation
        Hiroki Nagase; Nobuko Koshikawa; Takayoshi Watanabe; Hiroshi Sugiyama
        GENES & GENETIC SYSTEMS, Dec. 2012
      • Direct observation of reversible mechanical behaviors of photoresponsive oligonucleotides in DNA nanostructure
        Y. Yang; M. Endo; Y. Suzuki; K. Hidaka; H. Sugiyama
        The 39th International Symposium on Nucleic Acid Chemistry, Nagoya, Nov. 2012
      • Dynamic assembly and disassembly processes of photoresponsive DNA origami nanostructures captured by high-speed atomic force microscopy
        Y. Suzuki; M. Endo; Y. Yang; H. Sugiyama
        7th Annual Symposium on Nanobiotechnology, Bristol, UK, Nov. 2012
      • Nanoparticle-based synthetic transcription factor mimics for reprogramming of cells
        KiBum Lee; Sahishnu Patel; Perry Yin; DongJu Jung; Norio Nakatsuji; Hiroshi Sugiyama
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012
      • ナノ空間でDNA1分子の動作を捉える : 極小の分子システムで操るナノマシン
        遠藤 政幸; 杉山 弘
        化学, May 2012
      • Two-Dimensional Self-Assembly and Photo-Cross-Linking Induced Thermal-Stabilization of DNA Origami Structures
        A. Rajendran; M. Endo; K. Hidaka; H. Sugiyama
        9th Conference on the Foundations of Nanoscience 2012, Snowbird, UT, Apr. 2012
      • DNA Origami Structures for Application to Single-Molecule Observation
        遠藤 政幸; 杉山 弘
        化学工業, Feb. 2012
      • 2SI-06 Direct Observation of Single Molecular Event in DNA Origami Frame(2SI The art of energetic and functional efficiency in biomoiecular machines on the single molecule level,Symposium,The 50th Annual Meeting of the Biophysical Society of Japan)
        Sugiyama Hiroshi
        Seibutsu Butsuri, 2012
      • Programmed Self-Assembly and Thermal-Stabilization of DNA Origami Nanostructure
        A. Rajendran; M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama
        The 38th International Symposium on Nucleic Acid Chemistry, Sapporo, Nov. 2011
      • バイオサイエンス DNAオリガミ法による多次元構造体の構築と高次機能化
        遠藤 政幸; 杉山 弘
        未来材料, May 2011
      • 生命の設計図だけではないDNAの機能 DNAオリガミとDNAナノマシン (特集 自己組織化の物理学)
        杉山 弘
        パリティ, May 2011
      • DNA binding molecules as a new tool to regulate cancer cell fate
        Hiroki Nagase; Makoto T. Kimura; Xiaofei Wang; Takayoshi Watanabe; Kyoko Fujiwara; Rajeev Mishra; Hiroshi Sugiyama; Noboru Fukuda; Tadashi Terui
        CANCER RESEARCH, Apr. 2011
      • Direct observation of the movement of DNA modifying enzymes in the DNA nanostructure
        Y. Katsuda; M. Endo; K. Hidaka; H. Sugiyama
        8th Conference on the Foundations of Nanoscience 2011, Snowbird, UT,, Apr. 2011, Peer-reviewed
      • A DNA nanochip for direct analysis of DNA base-excision repair
        杉山 弘
        化学工業, Feb. 2011
      • DNAオリガミでの生体分子の制御と直接観察 (2010年の成果の総まとめ 特集 物理科学,この1年) -- (生物物理)
        遠藤 政幸; 杉山 弘
        パリティ, Jan. 2011
      • Development of the immobilization technology of functional proteins on DNA origami
        E. Nakata; C. Uwatoko; F.F. Liew; S. Kiyonaka; Y. Mori; Y. Katsuta; M. Endo; H. Sugiyama; T. Morii
        The 38th International Symposium on Nucleic Acid Chemistry，Hokkaido，2011.11.9-11, 2011, Peer-reviewed
      • DNA origami上への機能性タンパク質固定化技術の開発
        中田栄司; 上床知佐奈; 劉芳芳; 清中茂樹; 森泰生; 勝田陽介; 遠藤政幸; 杉山弘; 森井孝
        第5回バイオ関連化学シンポジウム，つくば国際会議場「エポカルつくば」，2011.9.12-14, 2011, Peer-reviewed
      • Configurable assembly of DNA origami on MEMS by microfluidic device
        Chunmei Huang; Takahiro Saeki; Masayuki Endo; Hiroshi Sugiyama; Chen-Hsun Weng; Gwo-Bin Lee; Koji Sugano; Toshiyuki Tsuchiya; Osamu Tabata
        NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 2011, Peer-reviewed
      • The chemistry of the functional PI polyamides directed for applications in chemical biology
        板東 俊和; 杉山 弘
        京都大学低温物質科学研究センター誌, Dec. 2010
      • Programmed Self-Assembly of Pre-Designed DNA Nanoconstrcts for the preparation of suitable Platform for Nano-Bio Application
        A. Rajendran; M. Endo; T. Sugita; Y. Katsuda; K. Hidaka; H. Sugiyama
        Pacific Basin Societies (PACIFICHEM), Hawaii, Dec. 2010, Peer-reviewed
      • Direct Analysis of DNA Modifying and Repair Enzymes Using High-Speed Atomic Force Microscopy
        Y. Katsuda; M. Endo; K. Hidaka; H. Sugiyama
        The International Chemical Congress of Pacific Basin Societies (PACIFICHEM), Hawaii, Dec. 2010, Peer-reviewed
      • Direct Observation of Single Molecular Behavior of T7 RNA Polymerase on the Defined DNA Nanostructure
        M. Endo; K. Tatsumi; K. Terushima; Y. Katsuda; K. Hidaka; H. Sugiyama
        Pacific Basin Societies (PACIFICHEM), Hawaii, Dec. 2010, Peer-reviewed
      • Dynamic Conformational Switching via G-Quadruplex Formation Observed in the DNA Nanostructure
        Y. Sannohe; M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama
        The 37th International Symposium on Nucleic Acids Chemistry 2010, Yokohama, Nov. 2010, Peer-reviewed
      • 近畿支部 : 若者に魅力的な拠点を目指して
        杉山 弘
        化学と工業 = Chemistry and chemical industry, 01 Oct. 2010
      • Design and construction of DNA nanostructures and their applications
        遠藤 政幸; 杉山 弘
        Bio industry, Oct. 2010
      • DNAとジグソーパズル
        遠藤 政幸; 杉山 弘
        化学, Jun. 2010
      • Development of PI polyamide targeting human ABCA1 gene
        Akiko Tsunemi; Takahiro Ueno; Noboru Fukuda; Takayoshi Watanabe; Kazunobu Tahira; Shiro Matsumoto; Chinami Nagura; Taro Matsumoto; Masayoshi Soma; Koichi Matsumoto; Yoshiaki Matsumoto; Hiroki Nagase; Hiroshi Sugiyama
        ENDOCRINE JOURNAL, Mar. 2010
      • Direct observation and control of enzymatic reaction in DNA frame
        H. Sugiyama; M. Endo
        7th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2010, 2010, Peer-reviewed
      • Development of Novel Therapeutic Strategies to Prevent the Development of Kidney Disease
        MATSUMOTO Koichi; FUKUDA Noboru; UENO Takahiro; IKEDA Kazuya; NAGURA Chinami; KAJIWARA Mamiko; MATSUMOTO Shiro; MARUYAMA Takashi; RA Chisei; SAITO Isao; MATSUMOTO Yoshiaki; SUGIYAMA Hiroshi
        Journal of Nihon University Medical Association, 01 Dec. 2009
      • Development of Novel Gene Silencing Medicine in Progressive Kidney Disease
        MATSUMOTO Koichi
        日大醫學雜誌, 01 Aug. 2009
      • Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (vol 62, pg 339, 2009)
        Tsukasa Suzuki; Yukihiro Asami; Teruyuki Takahashi; Xiaofei Wang; Takayoshi Watanabe; Toshikazu Bando; Hiroshi Sugiyama; Noboru Fukuda; Hiroki Nagase
        JOURNAL OF ANTIBIOTICS, Jun. 2009
      • Targeted chromatin modification mediated by pyrrole-imidazole polyamide to control gene expression for cancer therapy
        Makoto Kimura; Maki Ikeda; Takayoshi Watanabe; Akimichi Ohtsuki; Tsukasa Suzuki; Hiroshi Sugiyama; Hiroki Nagase
        CANCER RESEARCH, May 2009
      • Lightweight actuator structure with SMA honeycomb core and CFRP skins
        Yoji Okabe; Hiroshi Sugiyama; Toru Inayoshi
        Proceedings of the ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems 2009, SMASIS2009, 2009, Peer-reviewed
      • Molecular design of sequence specific DNA alkylating agents.
        M. Minoshima; T. Bando; K. Shinohara; H. Sugiyama
        Nucleic acids symposium series (2004), 2009, Peer-reviewed
      • Three-dimensional DNA nanostructures constructed by folding of multiple rectangles.
        M. Endo; H. Sugiyama
        Nucleic acids symposium series (2004), 2009, Peer-reviewed
      • Shape-variable sandwich structure with SMA honeycomb core and CFRP skins
        Yoji Okabe; Hiroshi Sugiyama
        Proceedings of SPIE - The International Society for Optical Engineering, 2009, Peer-reviewed
      • Development of Gene Silencing Pyrrole-Imidazole Polyamide Targeting the TGF-β1 Promoter for Treatment of Progressive Renal Diseases
        MATSUDA Hiroyuki; FUKUDA Noboru; UENO Takahiro; TAHIRA Yoshiko; AYAME Hirohito; ZHANG Wen; BANDO Toshikazu; SUGIYAMA Hiroshi; SAITO Satoshi; MATSUMOTO Koichi; MUGISHIMA Hideo; SERIE Kazuo
        日大醫學雜誌, 01 Dec. 2008
      • Effects of pyrrole-imidazole polyamide targeting LOX-1 on the apoptosis of endothelium and intimal hyperplasia in balloon-injured rat carotid artery
        T. Ueno; N. Fukuda; K. Tahira; T. Matsumoto; H. Matsuda; A. Tsunemi; K. Matsumoto; H. Sugiyama; T. Sawamura
        JOURNAL OF HYPERTENSION, Jun. 2008
      • Development of a novel gene silencer PI polyamide targeting TGF-beta 1 for chronic renal diseases and restenosis of artery
        H. Matsuda; N. Fukuda; E. -H. Yao; T. Ueno; H. Sugiyama; K. Matsumoto
        JOURNAL OF HYPERTENSION, Jun. 2008
      • Identification and characterization of NTH homologue in C. elegans
        MORINAGA Hironobu; YONEKURA Shin-Ichiro; SUGIYAMA Hiroshi; YONEI Shuji; AKIYAMA Qiu-Mei
        The Japan Radiation Research Society Annual Meeting Abstracts, 2008
      • DNAの構造と反応性: 実験とシミュレーション
        杉山 弘
        日本化学会情報化学部会誌, 2008
      • User-friendly Synthesis and Photoirradiation of a Flavin-linked Oligomer
        Kino Katsuhito; Miyazawa Hiroshi; Sugiyama Hiroshi
        VITAMINS, 2008
      • Structural stability analysis of the intermediates in the folding pathway of human telomeric hybrid-1 G-quadruplex based on fragment molecular orbital method.
        H. Yagi; T. Mashimo; Y. Sannohe; H. Sugiyama
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • Orientation of ends of G-quadruplex structure investigated with end-extended oligonucleotides.
        Y. Sannohe; K. Sato; A. Matsugami; K. Shinohara; T. Mashimo; M. Katahira; H. Sugiyama
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • Folding pathways of hybrid-1 and hybrid-2 G-quadruplex structures.
        T. Mashimo; Y. Sannohe; H. Yagi; H. Sugiyama
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • Targeting specific gene by alkylating pyrrole-imidazole polyamides.
        M. Minoshima; J. Chou; S. Lefebvre; T. Bando; K. Shinohara; J.M. Gottesfeld; H. Sugiyama
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction.
        G. Kashiwazaki; T. Bando; H. Sugiyama
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • DNA結合性化合物の応用--テロメアを分子標的とした抗がん剤 (特集 新しいナノバイオテクノロジーの進展(1))
        杉山 弘
        ケミカルエンジニヤリング, Jun. 2007
      • ハロウラシルの光反応性を利用したDNAの構造と電子移動の解析
        田代 竜; 杉山 弘
        放射線生物研究, Jun. 2007
      • 1P342 Single molecule FRET measurement of three dimensional G-quadruplex structure of human telomere DNA with Br-modification(New biophysical techniques and instrumentation,Poster Presentations)
        Okamoto Kenji; Sannohe Yuta; Mashimo Tomoko; Sugiyama Hiroshi; Terazima Masahide
        Seibutsu Butsuri, 2007
      • OPTIMIZATION AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY WITH UV DETECTION FOR DETERMINATION OF PYRROLE-IMIDAZOLE POLYAMIDES IN RAT PLASMA
        Akiko Fukasawa; Takashi Nagashima; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        DRUG METABOLISM REVIEWS, 2007
      • ESTABLISHMENT OF SOLID-PHASE EXTRACTION METHOD FOR THE RECOVERY OF PYRROLE-IMIDAZOLE POLYAMIDES FROM RAT URINE USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEM WITH ULTRAVIOLET DETECTOR
        Takashi Nagashima; Akiko Fukasawa; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
        DRUG METABOLISM REVIEWS, 2007
      • User-friendly Synthesis and Photoirradiation of a Flavin-linked Oligomer
        Katsuhito Kino; Hiroshi Miyazawa; Hiroshi Sugiyama
        Genes and Environment, 2007
      • T-loop formation by human telomeric G-quadruplex.
        Y. Xu; H. Sato; K. Shinohara; M. Komiyama; H. Sugiyama
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Chemical biology that controls DNA structure and function.
        H. Sugiyama
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Development of gene silencing pyrroleimidazole polyamide targeted to the TGF-beta1 promoter for treatment of progressive renal diseases
        Hiroyuki Matsuda; Noboru Fukuda; Takahiro Ueno; Yoshiko Tahira; Ryo Suzuki; Yukihiro Ikeda; Hiroto Takagi; Mayumi Katakawa; Koichi Matsumoto; Hiroshi Sugiyama
        JOURNAL OF HYPERTENSION, Dec. 2006
      • Pyrrole-imidazole polyamide targeting human lectin-like oxidized LDL receptor 1 gene reduced endothelial cell apoptosis induced by angiotensin II and oxidized LDL
        Takahiro Ueno; Noboru Fukuda; Akiko Tsunemi; Kazunobu Tahira; Taro Matsumoto; Hiroyuki Matsuda; Siro Matsumoto; Koichi Matsumoto; Hiroshi Sugiyama; Tatsuya Sawamura
        JOURNAL OF HYPERTENSION, Dec. 2006
      • Structural Biology of Functional RNA and DNA
        MATSUGAMI Akimasa; KOIZUMI Daisuke; OHYAMA Takako; INADA Masashi; TSUCHIBAYASHI Hiroaki; NAGATA Takashi; XU Yan; NOGUCHI Yuuki; SUGIYAMA Hiroshi; UMEHARA Takuya; NISHIKAWA Fumiko; NISHIKAWA Satoshi; KATAHIRA Masato; KATAHIRA Masato; KATAHIRA Masato
        Abstr Annu Meet NMR Soc Jpn, Nov. 2006
      • Photoreactivation of DNA by an archaeal nucleoprotein Sso7d
        Ryu Tashiro; Andrew H-J. Wang; Hiroshi Sugiyama
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2006, Peer-reviewed
      • 新規遺伝子発現抑制薬ピロールイミダゾールポリアミドの効果
        上野 高浩; 福田 昇; 松本 紘一; 杉山 弘
        日本臨床生理学会雑誌 = Japanese journal of applied physiology, 01 Aug. 2006
      • Effects of synthetic pyrrole-imidazole polyamide targeting TGF-b1 promoter on TGF-b1 expression and renal injury in rats
        H Matsuda; N Fukuda; T Ueno; K Matsumoto; H Sugiyama
        JOURNAL OF GENE MEDICINE, Mar. 2006
      • Effects of synthetic pyrrole-imidazole polyamide targeting TGF-b1 promoter on TGF-b1 expression and renal injury in rats
        H Matsuda; N Fukuda; T Ueno; K Matsumoto; H Sugiyama
        JOURNAL OF GENE MEDICINE, Mar. 2006
      • Incorporation of oxidized dNTPs by Y-family DNA polymerases.
        SHIMIZU Masatomi; YAMADA Masami; GRUZ Petr; NUNOSHIBA Tatsuo; XU Yan; MASUTANI Chikahide; USUI Yukio; SUGIYAMA Hiroshi; HANAOKA Fumio; NOHMI Takehiko
        The Japan Radiation Research Society Annual Meeting Abstracts, 2006
      • The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides.
        S. Sasaki; M. Minoshima; T. Shimizu; J. Fujimoto; K. Shinohara; T. Bando; H. Sugiyama
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • Detection of photoinduced electron transfer from Sso7d to DNA.
        R. Tashiro; A.H. Wang; H. Sugiyama
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • The recognition of higher-order G-quadruplex by chiral cyclic-helicene molecules.
        Y. Xu; S. Yamazaki; H. Osuga; H. Sugiyama
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • The new models of the human telomere DNA in K+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines.
        A. Matsugami; H. Tsuchibayashi; Y. Xu; Y. Noguchi; H. Sugiyama; M. Katahira
        Nucleic acids symposium series (2004), 2006, Peer-reviewed
      • DNAを中心としたケミカルバイオロジー
        杉山 弘
        現代化学, Mar. 2005
      • 配列特異的アルキル化剤の医薬品としての可能性
        板東俊和; 喜納克仁; 宮澤宏; 杉山弘
        医薬品研究, 2005
      • Inhibition of Telomerase with G-quadruplex-Stabilizing Molecules.
        Shinohara, K; Xu, Y; Sugiyama, H
        Chemistry, 2005
      • Reactivity of 2\\'-deoxyuridin-1\\'-yl radical in various DNA structures.
        W. Hasiba; Y. Xu; H. Sugiyama
        Nucleic acids symposium series (2004), 2005, Peer-reviewed
      • Sequence-specific gene silencing by alkylating Py-Im polyamide.
        K. Shinohara; S. Sasaki; T. Bando; H. Sugiyama
        Nucleic acids symposium series (2004), 2005, Peer-reviewed
      • Structural and functional characterizations of the G-quartet and i-motif elements in retinoblastoma susceptibility genes (Rb).
        Y. Xu; H. Sugiyama
        Nucleic acids symposium series (2004), 2005, Peer-reviewed
      • テーラーメイド抗がん剤の創製 (特集 先端バイオナノテクノロジーの開発と応用)
        杉山 弘
        化学工業, Apr. 2004
      • The recognition of Z-DNA by chiral helicene.
        Y. Xu; H. Sugiyama; K. Tanaka; H. Osuga
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • Analysis of distamycin A binding to UV-damaged DNA.
        A. Inase; T.S. Kodama; J. Sharif; Y. Xu; H. Ayame; H. Sugiyama; S. Iwai
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • The molecular-thermometer based on B-Z transition of DNA.
        R. Tashiro; H. Sugiyama
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • Translesion synthesis by human DNA polymerase eta across oxidative products of guanine.
        Katuhito Kino; Nobutoshi Ito; Kaoru Sugasawa; Hiroshi Sugiyama; Fumio Hanaoka
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • Molecular design of alkylating pyrrole-imidazole polyamides with indole linker.
        S. Sasaki; A. Narita; T. Bando; H. Sugiyama
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • Efficient generation of 2\\'-deoxyuridin-5-yl at 5\\'-(G/C)AA(X)U(X)U-3\\' (X = Br, I) sequences in duplex DNA under UV-irradiation.
        T. Watanabe; T. Bando; Y. Xu; H. Sugiyama
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • UVA-induced degradation of 8-hydroxyguanine in oligonucleotide and the effect on its activities in yeast oligonucleotide transformation assay.
        Y. Okugawa; C. Otsuka; D. Loakes; H. Sugiyama; K. Negishi
        Nucleic acids symposium series (2004), 2004, Peer-reviewed
      • Development of pyrrole-imidazole polyamides targeting TGF-beta 1 promoter as a gene therapy for the arterial proliferative diseases
        Y Lai; N Fukuda; H Kishioka; H Matsuda; S Saito; K Matsumoto; K Kanmatsuse; H Sugiyama
        ATHEROSCLEROSIS SUPPLEMENTS, Sep. 2003
      • Deglycopeplomycin metal complexes on DNA-fibers: a role of the sugar moiety for the stability and the orientation of the complexes
        M Chikira; T Iiyama; T Oyoshi; H Sugiyama
        JOURNAL OF INORGANIC BIOCHEMISTRY, Aug. 2001
      • DNAの局所構造を反映した水素引き抜き反応
        喜納 克仁; 大吉 崇文; 杉山 弘
        生体材料工学研究所年報, 2001
      • ポストゲノムの生物有機化学
        齋藤 烈; 齋藤 烈; 杉山 弘; 飯田博一; 中谷和彦; 山東信介
        化学同人, 2001
      • GC-->CG transversion mutation might be caused by 8-oxoguanine oxidation product.
        K. Kino; H. Sugiyama
        Nucleic acids symposium series, 2000, Peer-reviewed
      • The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity.
        T. Bando; H. Iida; I. Saito; H. Sugiyama
        Nucleic acids symposium series, 2000, Peer-reviewed
      • Synthesis of 6-(2-thienyl)purine nucleoside derivatives toward the expansion of the genetic code.
        T. Fujiwara; H. Sugiyama; I. Hirao; S. Yokoyama
        Nucleic acids symposium series, 2000, Peer-reviewed
      • Combinatorial approaches to targeting tumor-specific gene sequences.
        H Sugiyama; ZF Tao; T Fujiwara; Saito, I
        CLINICAL CANCER RESEARCH, Nov. 1999
      • Highly efficient DNA interstrand crosslinking induced by an antitumor antibiotic, carzinophilin
        T Fujiwara; Saito, I; H Sugiyama
        TETRAHEDRON LETTERS, Jan. 1999
      • Synthesis of pyrrole-imidazole-duocarmycin polyamide and its sequence selective DNA alkylation.
        T. Fujiwara; Z.F. Tao; I. Saito; H. Sugiyama
        Nucleic acids symposium series, 1999, Peer-reviewed
      • Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex.
        T. Oyoshi; H. Sugiyama; A.H. Wang
        Nucleic acids symposium series, 1999, Peer-reviewed
      • Amplification of bleomycin-induced DNA cleavage by pyrrole triamide.
        Y. Hiraku; S. Oikawa; S. Kawanishi; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1999, Peer-reviewed
      • Cleavage of parallel-stranded DNA duplex by peplomycin metal complexes.
        S. Ikeda; I. Saito; H. Sugiyama
        Nucleic acids symposium series, 1999, Peer-reviewed
      • Mechanisms for mutation induction and exzymatic repair of 5-formyluracil, a major oxidative lesion of thymine in DNA
        ZHANG Qiu-Mei; MIYABE Izumi; SUGIYAMA Hiroshu; YONEI Shuji
        日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998
      • Product analysis of GG-specific photooxidation of DNA via electron transfer: 2-aminoimidazolone as a major guanine oxidation product
        K Kino; Saito, I; H Sugiyama
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 1998
      • DNAの5′-GG-3′配列選択的な酸化的損傷の分子機構
        杉山 弘; 喜納 克仁; 斎藤 烈
        放射線生物研究, Jun. 1998
      • Molecular mechanism of GG-specific photooxidation of DNA
        Katsuhito Kino; Hiroshi Sugiyama
        Journal of Medical and Dental Sciences, 1998
      • Possibility of GC-CG Trnsversion Induced by Guanine Oxidation Product, Imidazolone
        齋藤 烈; K, Kino; I. Saito; H. Sugiyama
        Nucleic Acids Sym. Series, 1998
      • Conformation-dependent Photochemistry of 5-Halouracil-containing DNA: Spcific Ribose 2’-Hydroxylation in Z-Form DNA
        齋藤 烈; K. Kawai; H. Sugiyama; I. Saito
        Nucleic Acids Sym. Series, 1998
      • Guanine-guanine stacking rule for specific cleavage of duplex DNA by photoinduced electron transfer
        T Nakamura; M Takayama; C Dohno; K Nakatani; H Sugiyama; Saito, I
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1997
      • Photoreaction of 5-halouracil-containing Z-form DNA.
        K Kawai; H Sugiyama; Saito, I
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1997
      • Synthesis of puromycin-nucleic acid hybrids by DNA automated-synthesizer
        S Ikeda; H Sugiyama; Saito, I
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1997
      • Structure of DNA containing aristeromycin analog.
        T. Fujiwara; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1997, Peer-reviewed
      • Analysis of guanine oxidation product via electron transfer in 5\\'-d(TTGGTA)-3\\'.
        K. Kino; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1997, Peer-reviewed
      • Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A
        H Sugiyama; CY Lian; M Isomura; Saito, I; AHJ Wang
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1996, Peer-reviewed
      • 5-フォルミルウラシル : その生成, 生物作用および修復の機構
        張 秋海; 小林 元悟; 杉山 弘; 松田 成生; 斉藤 烈; 米井 脩治
        日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996
      • DNAの酸化的切断の分子機構(DNAの切断) (核酸化学の新展開--新しい機能性分子を求めて) -- (核酸の機能)
        杉山 弘
        蛋白質核酸酵素, Jul. 1995
      • PHOTOINDUCED DNA CLEAVAGE VIA ELECTRON-TRANSFER - DEMONSTRATION THAT GUANINE RESIDUES LOCATED 5' TO GUANINE ARE THE MOST ELECTRON-DONATING SITES
        SAITO, I; M TAKAYAMA; H SUGIYAMA; K NAKATANI
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1995
      • Synthesis of oligonucleotides containing a carbocyclic nucleoside.
        Y. Komeda; K. Sakata; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1995, Peer-reviewed
      • The most electron-donating sites in duplex DNA: guanine-guanine stacking rule.
        I. Saito; M. Takayama; T. Nakamura; H. Sugiyama; Y. Komeda; M. Iwasaki
        Nucleic acids symposium series, 1995, Peer-reviewed
      • 8-Methylguanine-containing oligonucleotides: useful structural constraint for Z form DNA.
        K. Kawai; H. Sugiyama; K. Fujimoto; I. Saito
        Nucleic acids symposium series, 1995, Peer-reviewed
      • Photoreaction of 5-bromouracil-containing DNA.
        K. Fujimoto; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1995, Peer-reviewed
      • Efficient guanine alkylation through cooperative heterodimeric formation of duocarmycin A and distamycin A.
        M. Isomura; H. Sugiyama; I. Saito
        Nucleic acids symposium series, 1995, Peer-reviewed
      • DNAをタ-ゲットとする抗ガン剤の分子機構
        杉山 弘; 斉藤 烈
        化学と生物, Feb. 1994
      • Mechanism of DNA Strand Cleavage by Antitumor Antibiotics.
        SUGIYAMA Hiroshi; SAITO Isao
        Kagaku To Seibutsu, 1994
      • Chemistry of oxidative DNA strand scission.
        H. Sugiyama; K. Fujimoto; K. Hatano; K. Ohmori; I. Saito
        Nucleic acids symposium series, 1993, Peer-reviewed
      • 第8回横浜21世紀フォ-ラム国際シンポ「分子構造と生命」に参加して (1992年の化学-4-)
        杉山 弘
        化学, Apr. 1992
      • Photochemical deoxyribose C2' oxidation in 5-iodouracil-containing hexanucleotide.
        H. Sugiyama; E. Yamaguchi; K. Yamashita; K. Fujimoto; Y. Tsutsumi; I. Saito
        Nucleic acids symposium series, 1992, Peer-reviewed
      • Site specific covalent alkylation of DNA by antitumor antibiotics, duocarmycin A and kapurimycin A3.
        H. Sugiyama; C.K. Lam; M. Hosoda; I. Saito
        Nucleic acids symposium series, 1991, Peer-reviewed
      • Current density dependence of microstructure and lattice expansion in porous silicon layers prepared by anodization
        Kuniko Takemoto; Hiroshi Sugiyama; Osamu Nittono
        Conference on Solid State Devices and Materials, 1991, Peer-reviewed
      • DNA STRAND SCISSION BY NEOCARZINOSTATIN - MOLECULAR RECOGNITION PROCESS RESPONSIBLE FOR SITE-SPECIFICITY
        H SUGIYAMA; T FUJIWARA; H KAWABATA; SAITO, I; N HIRAYAMA; N YODA
        SYMPOSIUM ON NUCLEIC ACIDS TECHNOLOGY, 1990, Peer-reviewed
      • DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTICS - DETECTION OF C-4'-HYDROXYLATED ABASIC SITES IN DNA
        H SUGIYAMA; H KAWABATA; T FUJIWARA; Y DANNOUE; T TASHIRO; T MATSUURA; SAITO, I
        SIXTEENTH SYMPOSIUM ON NUCLEIC ACIDS CHEMISTRY, 1989, Peer-reviewed
      • ブレオマイシンによるDNA切断 (化学のフロンティア-4-若い視点・挑戦) -- (生体関連化学)
        杉山 弘
        化学と工業, Mar. 1988
      • 22 Molecular Mechanisms of the Sequence-Specific Recognition and Cleavage Reaction of DNA by Bleomycin
        Saito Isao; Morii Takashi; Sugiyama Hiroshi; Matsuura Teruo
        Symposium on the Chemistry of Natural Products, symposium papers, 1987
      • Structure and chemistry of alkali-labile product formed during Fe(II)-bleomycin-mediated DNA strand scission.
        H. Sugiyama; T. Morii; I. Saito; T. Matsuura; S.M. Hecht
        Nucleic acids symposium series, 1986, Peer-reviewed
      • CHEMISTRY OF NUCLEOSIDE-AMINO ACID ADDUCTS AND ITS RELEVANCE TO PHOTOINDUCED LESIONS
        SAITO, I; H SUGIYAMA; MB GUPTA; T MATSUURA
        HETEROCYCLES, 1984
      • PHOTOCHEMICAL-REACTIONS OF NUCLEIC-ACIDS AND THEIR CONSTITUENTS OF PHOTOBIOLOGICAL RELEVANCE
        SAITO, I; H SUGIYAMA; T MATSUURA
        PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1983
      • SITE-SPECIFIC CHEMICAL-REACTIONS OF DNA THROUGH MOLECULAR RECOGNITION
        SAITO, I; H SUGIYAMA
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1982
      • PHOTOREACTION OF THYMIDINE IN THE PRESENCE OF LYSINE - PHOTOCHEMISTRY OF NUCLEIC-ACID BASE
        SAITO, I; S ITO; H SUGIYAMA; T MATSUURA
        HETEROCYCLES, 1981
      • Photoreaction of thymidine with primary amines. Application to specific modification of DNA.
        I. Saito; H. Sugiyama; N. Furukawa; T. Matsuura
        Nucleic acids symposium series, 1981, Peer-reviewed
      • Direct visualization of Cre-mediated site-specific recombination in the DNA origami scaffold
        Y. Suzuki; Y. Katsuda; K. Ou; K. Hidaka; M. Endo; H. Sugiyama
        The 39th International Symposium on Nucleic Acid Chemistry, Nagoya, Peer-reviewed
      • Controlled Movement of DNA Molecules on the Designed Pathway and Junctions
        Y. Katsuda; M. Endo; K. Hidaka; S. F. J. Wickham; J. Bath; A. J. Turberfield; H. Sugiyama
        The 38th International Symposium on Nucleic Acid Chemistry, Sapporo, Peer-reviewed

      Presentations

      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
        杉山 弘
        IUPAC International Symposium on Bioorganic Chemistry (ISBOC-12), Tsinghua Shenzhen International School (Tsinghua SIGS), Shenzhen, China, 16 Dec. 2019, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
        杉山 弘
        The 10th International Symposium, Interdisciplinary Science and Technology Innovations for Sustainable Society, Osaka University Hall, Toyonaka, Osaka, Japan, 09 Dec. 2019, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
        杉山 弘
        The K. T. Wang Bioorganic Chemistry Foundation Lecture, National Biotechnology Research Park, Taipei, Taiwan, 23 Oct. 2019, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
        杉山 弘
        2019 KSBB Fall Meeting and International Symposium: Biotechnology from the Nature to Human Life, EXCO, Daegu, Korea, 10 Oct. 2019, Invited
      • Chemical Biology of Nucleic: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Asia 3 Roundtable of Nucleic Acids (A3RONA 2019), Jibasan Building, Himeji, Japan, Oct. 2019, Invited
      • Chemical Biology of G-Quadruplex
        杉山 弘
        The 7th International Meeting on Quadruplex Nucleic Acids, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China, 07 Sep. 2019, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019), Kobe, Japan, 23 Jul. 2019, Invited
      • Chemical Biology of Nucleic Acids: Recent Progress of DNA Origami and Artificial Genetic Switch
        杉山 弘
        Nucleosides, Nucleotides and Oligonucleotides Gordon Research Conference, Salve Regina University, Newport, USA, Jun. 2019
      • Chemical biology of DNA local conformation
        杉山 弘
        18th TMIMS International Symposium on Structured nucleic acids: its recognition mechanisms, biology and diseases, Tokyo, Japan, 19 Dec. 2018, Invited
      • Chemical biology of nucleic acids: DNA origami and artificial genetic switch
        杉山 弘
        Asian 3 Roundtable on Nucleic Acids 2018 (A3RONA 2018), Korea, 15 Sep. 2018, Invited
      • Chemical biology of nucleic acids: DNA origami and artificial genetic switch
        杉山 弘
        XXIII International Roundtable on Nucleodides, Nucleotides and Nucleic Acids, University of California, San Diego, La Jolla, California, USA, 29 Aug. 2018, Invited
      • Deciphering of Nucleosome Structure Using an Emissive Nucleobase FRET Pair
        杉山 弘
        Fluorescent Biomolecules and their Building Blocks (FB3), University of Glasgow, Glasgow, England, 01 Jul. 2018, Invited
      • Pyrrole-imidazole Polyamides: Artificial Genetic Switches for Therapeutic Gene Modulation
        杉山 弘
        13th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS), Bordeaux Palais de la Bourse, Bordeaux, France, 24 Sep. 2017, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Gordon Research Conference, Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University Newport, RI, USA, 29 Jun. 2017, Invited
      • Chemical Biology of Nucleic Acids: G-quadruplex and DNA origami
        杉山 弘
        6th International Meeting on Quadruplex Nucleic Acids, Prague, Czech Republic, 01 Jun. 2017, Invited
      • Chemical Biology of Nucleic Acids: DNA origami and Artificial Genetic Switch
        杉山 弘
        The Catalysis and Sensing For Our Symposium 2017, Shanghai, China, 16 May 2017, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch
        杉山 弘
        BORDEAUX FOLDAMERS 2016 SYMPOSIUM, Institut Européen de Chimie et Biologie, Bordeaux-Pessac, France, 28 Sep. 2016, Invited
      • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch
        杉山 弘
        The First A3 Roundtable Meeting on Chemical Probe Research Hub, Hakata, Fukuoka, 23 Sep. 2016, Invited
      • Artificial epigenetic switches for therapeutic gene modulation
        杉山 弘
        The 9th International Symposium on Nanomedicine, Mie University, Mie, Japan, 10 Dec. 2015, Invited
      • Single-molecule imaging of molecular motions in the DNA origami scaffold
        杉山 弘
        The 4th International Conference on DNA Nanotechnology, Xian, China, 28 Jun. 2015, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        The 8th International Symposium on NanoBiotechnology, 20 Oct. 2014, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Telluride Meeting, Telluride, USA, 28 Jul. 2014, Invited
      • SINGLE-MOLECULE OBSERVATION IN THE DNA ORIGAMI NANOSTRUCTURES
        杉山 弘
        The 3rd International DNA Nanotechnology Conference, Suzhou, China, 26 May 2014, Invited
      • Single-Molecule Observation in the DNA Origami Nanostructures
        杉山 弘
        Biophysical Society 58th Annual Meeting, Nanoscale Biophysics Subgroup 2014 Symposium, San Francisco, USA, 15 Feb. 2014, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        The 13th Tateshina Conference on Organic Chemistry, Nagano, 10 Nov. 2013, Invited
      • Chemical Biology that Controls Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        The 8th National Conference on Chemical Biology of China, Shanghai, 16 Sep. 2013, Invited
      • Chemical Biology that Controls Structure and Function of DNA
        杉山 弘
        A3RONA 2013 Japan (Asian 3 Roundtable on Nucleic. Acids), Kobe, 01 Sep. 2013, Invited
      • Artificial Genetic Switch based on Pyrrole-Imidazole Polyamide
        杉山 弘
        Asian Chemical Biology Initiative 2013 Bangkok Meeting, 27 Jan. 2013, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        17th Malaysian Chemical Congress (17MCC), Kuala Lumpure, Malaysia, 16 Oct. 2012, Invited
      • Chemical Biology that Controls Structure and Function of DNA
        杉山 弘
        A3RONA 2012 Korea (Asian 3 Roundtable on Nucleic. Acids), 20 May 2012, Invited
      • Direct Observation of Single Molecular Event in DNA Origami Frame
        杉山 弘
        2012 MRS (Materials Research Society) Spring Meeting, Symposium NN: DNA Nanotechnology, California, USA, 11 Apr. 2012, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Asian 3 Roundtable on Nucleic acids, Wuhan, China, 15 Oct. 2011, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        14th Asian Chemical Congress (14ACC), Bangkok, 07 Sep. 2011, Invited
      • Visualization of DNA structural change in the DNA nanostructure
        杉山 弘
        8th Annual Conference Foundations of Nanoscience (FNANO11) Self-Assembled Architectures and Devices, Utah, USA, 14 Apr. 2011, Invited
      • PI Polyamide as a Artificial Genetic Switch
        杉山 弘
        The International Chemical Congress of Pacific Basin Societies (PACIFICHEM), Hawaii, 17 Dec. 2010, Invited
      • Chemical Biology of Human Telomere Repeat Sequence
        杉山 弘
        The International Chemical Congress of Pacific Basin Societies (PACIFICHEM), Hawaii, 15 Dec. 2010, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        A3RONA 2010 Japan (Asian 3 Roundtable on Nucleic. Acids 2010, Japan), Osaka, 30 Oct. 2010, Invited
      • Direct Observation of Enzymatic Reaction in DNA Origami Frame
        杉山 弘
        4th Annual Symposium on Nanobiotechnology, Munich, Germany, 06 Oct. 2010, Invited
      • DNA Origami for Observation of Single Molecular Behaviors
        杉山 弘
        Tellride Science Research Center Workshop (Nucleic Acid Topics), Tellrede, USA, 03 Aug. 2010, Invited
      • Chemical Biology that controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        The 3rd International Symposium on Bio-Inspired Engineering, Taipei, Taiwan, 22 Oct. 2009, Invited
      • Synthesis and Biological Properties of Sequence-Specific DNA-alkylating Pyrrole-Imidazole Polyamides
        杉山 弘
        The Next Generation Japanese Technology Showcase, New York, USA, 14 Jan. 2009, Invited
      • Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        First Symposium on Egypt-Japan University of Science and Technology, Alexandria, Egypt, 26 Nov. 2008, Invited
      • Chemical biology that controls DNA structure and function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        Nucleic Acid Topics, Telluride, USA, 04 Aug. 2008, Invited
      • Chemical biology that controls DNA structure and function: DNA Origami and Artificial Genetic Switch
        杉山 弘
        5th International Symposium on Nucleic Acids Chemistry (34th Symposium on Nucleic Acids Chemistry), Tokyo, 21 Nov. 2007, Invited
      • Chiral wedge molecule inhibits telomerase activity
        杉山 弘
        First International Meeting on Quadruplex DNA, Louisville, KY, USA, Apr. 2007, Invited
      • Selective Gene Silencing by Alkylating Pyrrole-Imidazole Polyamide
        杉山 弘
        KEYSTONE SYMPOSIA, Taos, New Mexico, USA, Apr. 2006, Invited
      • Structural Elucidation and Design of Specific Binder of G-Quadruplex
        杉山 弘
        Telomere and Telomerase in Cancer Research Taipei 2006 meeting, Taipei, Taiwan, Mar. 2006, Invited
      • Structural elucidation and design of specific binder of G-quartet
        杉山 弘
        Pacifichem 2005 Congress, Honolulu, USA, Dec. 2005, Invited
      • Photochemistry of 5-Halouracil containing DNA
        杉山 弘
        11th congress of the European Society for Photobiology, Aix-les-Bains, France, Sep. 2005, Invited
      • Photoreaction of 5-Halouracil-ContainingDNA
        杉山 弘
        14th International Congress on Photobiology Jeju, Korea, Jun. 2004, Invited
      • Photoreaction of 5-Halouracil-Containing Z-Form DNA
        杉山 弘
        The 21stInternational Conference on Photochemistry (ICP21), Nara, Jul. 2003, Invited

      Books and Other Publications

      Industrial Property Rights

      • 特願2017-100814, ピロール－イミダゾールポリアミド化合物群を用いた内在性制御因子のスクリーニング方法
        杉山 弘; 上久保靖彦
      • 特願2016-234399, RUNX阻害剤
        杉山 弘; 上久保靖彦
      • 特願PCT/JP2016/054162, 特定遺伝子の発現を活性化するCTB-PIポリアミドコンジュゲート
        杉山弘; 板東俊和
      • 特願PCT/JP2014/077766, ドライバーオンコジーンの遺伝子変異を標的にアルキル化する新規アルキル化剤
        永瀬浩喜; 杉山弘; 板東俊和
      • 特願PCT/JP2009/062054, 標的遺伝子特異的ヒストン修飾制御剤
        永瀬 浩喜; 杉山 弘; 鈴木 元; 板東 俊和; 木村 真; 大朏 彰道

      Awards

      • Jul. 2018
        日本光医学・光生物学会, 第40回日本光医学・光生物学会賞
      • Mar. 2018
        日本化学会, 第70回日本化学会賞
      • Mar. 2005
        日本化学会, 第22回日本化学会学術賞
      • Dec. 1999
        日本アイ・ビー・エム株式会社, 日本IBM科学賞

      External funds: Kakenhi

      • Development of molecules that control gene networks and their application to cells
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        Hiroshi SUGIYAMA
        From 05 Apr. 2021, To 31 Mar. 2024, Project Closed
        ケミカルバイオロジー;生物有機化学;遺伝子発現制御;ヌクレオソーム;DNAナノ構造体;AFM解析;ミトコンドリア;遺伝子発現
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04705/
      • A novel strategy for molecular diagnosis and prophylactic approach to non-syndromic cleft palate
        Grant-in-Aid for Scientific Research (B)
        Basic Section 57070:Developmental dentistry-related
        Osaka University
        山城 隆
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        口蓋裂;器官培養;Stat3;環境因子;遺伝因子;PIポリアミド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03148/
      • A novel strategy for dentin regeneration by transcriptional regulation of Runx2
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 57:Oral science and related fields
        Osaka University
        Takashi Yamashiro
        From 30 Jul. 2020, To 31 Mar. 2023, Project Closed
        Runx2;Wntシグナル;象牙芽細胞;歯髄細胞;Dspp;へパラン硫酸プロテオグリカン;PIポリアミド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21673/
      • Modality of nucleosome dynamics
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        National Institute of Genetics
        前島 一博
        From 19 Nov. 2020, To 31 Mar. 2025, Granted
        ヌクレオソーム;クロマチン;超解像顕微鏡;ゲノミックス解析;原子間力顕微鏡;ゲノミクス解析;超解像イメージング;AFM;PIポリアミド
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05936/
      • Study to develop nucleic acid analog to inhibit transcription network to maintain glioma stemness
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
        Kyoto University
        Susumu Miyamoto
        From 28 Jun. 2019, To 31 Mar. 2021, Project Closed
        がん幹細胞;グリオーマ;ステムネス;マスター転写因子;SOX2;転写ネットワーク;転写活性制御;核酸類似化合物;腫瘍幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22685/
      • Development of Artificial Transcription Factors for Cooperative Regulation of Cardiomyopathy-Related Mitochondrial and Nuclear Genes
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
        Kyoto University
        Ganesh Pandian NAMASIVAYAM
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        Transcription therapy;Epigenetic codes;Mitochondria;Reactive Oxygen Species;Energy metabolism;Nanoparticle;Immunotherapy;Heteroplasmy;ピロールイミダゾールポリアミド;エピジェネティクス;人工転写因子;ナノテクノロジー;心筋症
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03349/
      • Developing novel therapeutics for Translocation Renal Cell Carcinoma by sequence specific DNA alkylation
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
        Kumamoto University
        Masaya Baba
        From 29 Jun. 2018, To 31 Mar. 2020, Project Closed
        転座腎細胞癌;融合転写因子;TFE3;抗がん剤;創薬;コンセンサス配列;転座型腎細胞癌
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19619/
      • Hacking the sexual program of green algae by functional polyamides
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
        Kyoto University
        Yoshiki Nishimura
        From 29 Jun. 2018, To 31 Mar. 2021, Project Closed
        機能性ポリアミド;緑藻クラミドモナス;接合;細胞透過性;緑藻;生殖;生殖プログラム;シスエレメント
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19337/
      • Development of cancer immunity through innovative immune switch
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Yasuhiko Kamikubo
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        RUNX;遺伝子スイッチ;CROX;担癌マウスモデル;発現制御;癌;免疫学;シグナル伝達;薬理学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14632/
      • Regulation and mechanistic investigation of gene expression by artificial genetic switches
        Grant-in-Aid for Scientific Research (S)
        Kyoto University
        Hiroshi Sugiyama
        From 31 May 2016, To 31 Mar. 2021, Project Closed
        遺伝子発現制御;エピジェネティックス;DNAナノ構造体;AFM 解析;遺伝子発現;ピロールイミダゾールポリアミド;遺伝子スイッチ;原子間力顕微鏡;一分子解析;グルーブバインダー;塩基配列特異的結合
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06356/
      • Development of functional molecules for targeting circulating microRNA
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Asako Yamayoshi
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        核酸医薬;機能性分子開発;microRNA;エクソソーム;抗体結合型核酸;miRNA;DDS;アンチセンス核酸;exosome;抗体;核酸
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K05564/
      • Single-molecule characterization of target DNA search of tumor suppressor p53
        Grant-in-Aid for Young Scientists (B)
        Tohoku University
        Kiyoto Kamagata
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        蛋白質;DNA;１分子計測;１分子計測(SMD);遺伝子;単分子計測;天然変性蛋白質;探索;結合
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26840045/
      • Nature-inspired small molecules for regulation of therapeutically important genes
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Ganesh Pandian NAMASIVAYAM
        From 01 Apr. 2014, To 31 Mar. 2015, Project Closed
        天然分子を模倣した化合物;DNAベースの治療;遺伝子発現制御;マルチターゲットな小分子化合物;エピゲノム
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670055/
      • Selective modification of histone methylation using DNA binding-small molecules
        Grant-in-Aid for Scientific Research (C)
        Chiba University
        Ken-ichi Shinohara
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        ピロール・イミダゾール・ポリアミド;核酸化学;発現制御;エピゲノム;ヒストンメチル化;DNA配列認識;エピゲノム制御;ピロール・イミダゾールポリアミド;ピロール-イミダゾールポリアミド;エピジェネティクス
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26350977/
      • Development of programmable small molecules capable of switching ON the transcriptional machinery of pluripotency genes.
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Ganesh Pandian NAMASIVAYAM
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        人工遺伝子スイッチ;細胞リプログラミング;小分子;合成生物学;iPS細胞;人口遺伝子スイッチ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710261/
      • Control and elucidation of gene expression at a molecular level
        Grant-in-Aid for Scientific Research (S)
        Kyoto University
        Hiroshi SUGIYAMA
        From 31 May 2012, To 31 Mar. 2017, Project Closed
        遺伝子発現制御;エピジェネティックス;細胞初期化;Py-Imポリアミド;DNAナノ構造体;遺伝子発現;初期化;エピジェネティクス
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24225005/
      • Development of cancer therapy inducing histone acethylation at the specific region of cancer genome
        Grant-in-Aid for Scientific Research (B)
        Chiba Cancer Center (Research Institute)
        Hiroki NAGASE
        From 01 Apr. 2011, To 31 Mar. 2014, Project Closed
        ピロールイミダゾールポリアミド;ヒストンアセチル化;ヒストン脱アセチル化酵素阻害剤;がん;エピジェネティクス;ヒストン修飾;エピジェネティク;癌;リプログラミング;iPS細胞;SAHA;山中因子;内在性遺伝子の再発現
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300344/
      • Cell-biological analysis of sequence-specific DNA alkylating molecules.
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Shinohara KEN-ICHI
        From 01 Apr. 2008, To 31 Mar. 2010, Project Closed
        テロメア;核酸;Py-Imポリアミド;細胞老化;DNAアルキル化;PIポリアミド;白血病
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20710164/
      • Chemical Biology of DNA Structure and Functions
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Hiroshi SUGIYAMA
        From 01 Apr. 2007, To 31 Mar. 2011, Project Closed
        核酸;蛋白質;構造機能解析;光反応性;修飾塩基;5-ハロウラシル;DNA
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19205023/
      • Pyrrole-imidazole polyamides for suppression of hypoxia inducible factors in chemotherapy-resistant urogenital cancers
        Grant-in-Aid for Scientific Research (C)
        Tokyo Medical and Dental University
        Yukio KAGEYAMA
        From 01 Apr. 2005, To 31 Mar. 2008, Project Closed
        抗癌剤;ポリアミド;低酸素誘導転写因子;熱ショック蛋白;膀胱がん;尿路癌;抗がん剤;血管内皮成長因子;低酸素;転写;細胞周期, anticancer drugs;polyamide;Hypoxia inducible factor;heat shock protein;bladder cancer
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591667/
      • Pyrrole-imidazole polyamides against hormone refractory prostate cancer
        Grant-in-Aid for Scientific Research (C)
        Tokyo Medical and Dental University
        Nobuhiko HYOCHI
        From 01 Apr. 2005, To 31 Mar. 2008, Project Closed
        ポリアミド;前立腺がん;男性ホルモン受容体;抗男性ホルモン剤;遺伝子変異;前立腺癌;男性ホルモン;再燃, polyamide;prostate cancer;androgen receptor;antiandrogen
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591666/
      • Chemical biology based determination of DNA local structures in vivo
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Hiroshi SUGIYAMA
        From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
        構造解析;光反応;修飾塩基;Z型DNA;DNA四重鎖;修飾塩某, structural analysis;photoreaction;modified base;Z form DNA;G-quadruplex
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17201043/
      • Tailor-made Antitumor Agents based on DNA Sequence
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Hiroshi SUGIYAMA
        From 01 Apr. 2005, To 31 Mar. 2010, Project Closed
        Py-Imポリアミド;テーラーメード抗がん剤;塩基配列認識;配列特異的アルキル化;遺伝子発現制御;ピロール-イミダゾールポリアミド;配列特異的DNAアルキル化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016033/
      • Photochemical probe of DNA local structures
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Hiroshi SUGIYAMA
        From 01 Apr. 2003, To 31 Mar. 2005, Project Closed
        DNA;Z型DNA;光反応;5-ハロウラシル;DNA構造;DNAプローブ;構造解析;DNA損傷;修飾塩基, DNA;Z form DNA;photoreaction;H abstraction;DNA conformation;DNA probe;B-Z transition;5-halouracil
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15201046/
      • Suppression of VEGF transcription in renal cell carcinoma cells using pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element
        Grant-in-Aid for Scientific Research (B)
        Graduate School Tokyo Medical and Dental University
        Yukio KAGEYAMA
        From 01 Apr. 2002, To 31 Mar. 2005, Project Closed
        ポリアミド;腎臓癌;HIF;VEGF;血管新生;低酸素;転写因子;血管内皮成長因子;低酸素応答転写因子;HRE;血管新生抑制;ピロールイミダゾールポリアミド;腎癌, Polyamide;Renal cell cancer;Hypoxia inducible factor;VEGF;Neovascularization
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370505/
      • DNA塩基配列を正確に読み取るテーラーメード抗がん剤の開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University;Tokyo Medical and Dental University
        杉山 弘
        From 01 Apr. 2001, To 31 Mar. 2005, Project Closed
        ピロール-イミダゾールポリアミド;配列特異的DNAアルキル化;塩基配列認識;テーラーメード抗がん剤;遺伝子発現制御;DNAチップ;ピロールイミダゾールポリアミド;DNA塩基配列;コンビナトリアル合成
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13218046/
      • Sequence-Specific Alkylating Agent as A Novel Type of Antitumor Agent
        Grant-in-Aid for Scientific Research (A)
        Tokyo Medical and Dental University
        Hiroshi SUGIYAMA
        From 01 Apr. 2000, To 31 Mar. 2002, Project Closed
        抗がん剤;ピロールイミダゾールポリアミド;DNA塩基配列;ピロールイミダゾールポリアミ, Antitumor Agent;Pyrrole Imidazole Polyamide;Sequence-Specific Alkylation
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12358011/
      • DNA塩基配列を正確に読み取るテーラーメード抗がん剤の開発
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Tokyo Medical and Dental University
        杉山 弘
        From 01 Apr. 2000, To 31 Mar. 2002, Project Closed
        テーラーメード抗がん剤;コンビナトリアル合成;DNA塩基配列
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12217047/
      • Collaboration on DNA sequence-specific recognition by small molecules
        Grant-in-Aid for Scientific Research (B).
        Tokyo Medical and Dental University
        Hiroshi SUGIYAMA
        From 01 Apr. 1998, To 31 Mar. 2001, Project Closed
        ピロールイミダゾールポリアミド;抗生物質;塩基配列特異性;DNAアルキル化;ポストゲノム;抗がん剤;グルーブバインダー;分子認識;DNA分子認識;DNA構造;NMR;X線構造解析;ブレオマイシン;平行DNA, Antitumor Agent;Sequence-specific recognition of DNA;DNA alkylation;Post genome;Pyrrole-imidazole polyamides
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044134/
      • Design of Gene Therapeutic Agent Possessing Cooperative DNA Alkylating Ability
        Grant-in-Aid for Scientific Research (B)
        Tokyo Medical and Dental University
        Hiroshi SUGIYAMA
        From 01 Apr. 1997, To 31 Mar. 1999, Project Closed
        抗がん剤;ヘテロダイマー;デュオカルマイシン;デイスタマイシン;塩基配列;分子認識;DNAアルキル化;配列特異性;遺伝子治療;協同性, Antitumor agent;Heterodimer;Duocarmycin;Distamycin;DNA sequence;Molecular recognition
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09555283/
      • Synthesis of Puromycin Tethered RNA and It's Application for Molecular Evolution
        Grant-in-Aid for Scientific Research (B)
        Tokyo Medical and Dental University
        Hiroshi SUGIYAMA
        From 01 Apr. 1997, To 31 Mar. 1999, Project Closed
        ピューロマイシン;蛋白合成;mRNA;分子進化法;ヒューロマイシン;修飾RNA, Puromycin;Protein biosynthesis;mRNA;Molecular evolution
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09480139/
      • Probing DNA local structure by photoirradiation and application toward gene therapy.
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Hiroshi SUGIYAMA
        From 01 Apr. 1995, To 31 Mar. 1997, Project Closed
        DNA切断;光分子移動;ブロモウラシル;DNA構造;遺伝子治療;水素引き抜き;光電子移動;水素引きぬき, DNA cleavage;photo-electron-transfer;bromouracil;DNA structure;gene therapy;hydrogen abstraction
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07458143/
      • ブレオマイシン金属錯体による酸素活性化とDNA分子認識機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        杉山 弘
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        抗ガン剤;抗生物物質;ブレオマイシン;DNA切断;分子認識;DNA;酸素錯体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07216239/
      • Analysis of damage to human genes for estimating the carcinogenicity of environmental chemicals
        Grant-in-Aid for Developmental Scientific Research (B)
        KYOTO UNIVERSITY
        Shosuke KAWANISHI
        From 01 Apr. 1994, To 31 Mar. 1996, Project Closed
        ヒト遺伝子;Ameo試験;発がん物質;活性酸素種;DNA損傷;NADH;マンガン;複合作用;Ames試験;環境因子;金属イオン;トリプトファン代謝物;ペンタクロロフェノール;過酸化水素, human gene;Ame's test;carcinogen;active oxygen species;DNA damage;NADH;Mn;transition metal
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557028/
      • ブレオマイシン金属錯体による酸素活性化とDNA分子認識機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        杉山 弘
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        抗ガン剤;抗生物質;分子認識;DNA切断;ブレオマイシン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06227236/
      • Probing DNA Structure by Photoelectron Transter and Its Application toward Gene The rapy
        Grant-in-Aid for General Scientific Research (C)
        KYOTO UNIVERSITY
        Hiroshi SUGIYAMA
        From 01 Apr. 1993, To 31 Mar. 1995, Project Closed
        光電子移動;DNA局所構造;DNA切断;ブロモウラシル;電子移動;DNA構造;光遺伝子治療, photo electron transfer;DNA local conformatiom;DNA strand scission
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05680524/
      • ブレオマイシン金属錯体による酸素活性化とDNA分子認識機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        斉藤 烈
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        ブレオマイシン;分子認識;酸素活性化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05236221/
      • 特異的DNA切断分子の開発のための修飾オリゴヌクレオチドの大量合成とその高度利用
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        杉山 弘
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        DNA切断;オリゴヌクレオチド;DNA合成;アンチセンスDNA
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05210205/
      • 制がん剤のアンプリファイヤーによる効果増強機構の解析と新アンプリファイヤーの開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        川西 正祐
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        制がん剤;アンプリファイヤー;効果増強;DNA切断;デュオカルマイシンA;ディスタマイシンA;コンピューターグラフィックス;DNA認識;制がン剤;アンプリファィヤー;マイナーグルーブ;ネオカルジノスタチン;アクチノマイシンD
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04253219/
      • Design of Biofunctional Molecules based on Molecular Recognition
        Grant-in-Aid for General Scientific Research (A)
        KYOTO UNIVERSITY
        Isao SAITO
        From 01 Apr. 1992, To 31 Mar. 1995, Project Closed
        DNA切断;抗ガン剤;分子認識;超分子;人工蛋白質;分子設計;DNA切断分子;オリゴタクレオチド;DNA認識蛋白;人工制限酵素;ハイブリッド蛋白, DNA Recognition;DNA Cleaver;Antitumor Antibiotics;Bleomycins;Neocarzinostatin;DNA Cleavage
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04403010/
      • 特異的DNA切断分子の開発のための修飾オリゴタクレオチドの大量合成とその高度利用
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        杉山 弘
        From 01 Apr. 1992, To 31 Mar. 1993, Project Closed
        DNA切断分子;オリゴタクレオチド;DNA合成;アンチセンスDNA
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04226207/
      • ブレオマイシンのアンプリファイヤ-による効果増強機構の解析と新アンプリファイヤ-の開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        川西 正祐
        From 01 Apr. 1991, To 31 Mar. 1992, Project Closed
        ブレオマイシン;ディスタマイシンA;DNAシ-クエンジング法;DNA切断;抗生物質;デュオカルマイシン;ヒト培養細胞;アンプリファイヤ-
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03258219/
      • 制ガン剤ブレオマイシンおよびネオカルチノスタチンの分子機能解明とそのモデル化
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        斉藤 烈
        From 01 Apr. 1991, To 31 Mar. 1992, Project Closed
        制ガン剤;DNA切断;ブレオマイシン;ネオカルチノスタチン;分子認識;コンピュ-ク-グラフィクス
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03215217/
      • 特異的DNA切断分子の開発のための修飾オリゴタクレオチドの大量合成とその高度利用
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        杉山 弘
        From 01 Apr. 1990, To 31 Mar. 1991, Project Closed
        修飾オリゴヌクレオチド;DNA切断;5ーブロモウラシル;5ーヨ-ドウラシル;ブレオマイシン;ネオカルチノスタチン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03242205/
      • Design and Synthesis of DNA-Cleaving Molecules
        Grant-in-Aid for General Scientific Research (B)
        Kyoto University
        Isao SAITO
        From 01 Apr. 1990, To 31 Mar. 1992, Project Closed
        DNA切断;エンジエン系抗ガン剤;人工制限酵素;光によるDNA切断;水酸ラジカル発生剤;水酸ラジカル発生試薬;光DNA切断, DNA Cleavage;Ene-diyne Antitumor Antibiotics;Artificial Restriction Enzym;Photo-DNA-Cleavage;Hydroxyl Radical Cenerator
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02453023/
      • 制ガン剤ブレオマイシンおよびネオカルチノスタチンの分子機能解明とそのモデル化
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        斉藤 烈
        From 01 Apr. 1990, To 31 Mar. 1991, Project Closed
        制ガン剤;DNA切断;ブレオマイシン;ネオカルチノスタンチン;分子認識
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02231214/
      • 制ガン剤ブレオマイシンおよびネオカルチノスタチンの分子機能解明とそのモデル化
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        斉藤 烈
        From 01 Apr. 1989, To 31 Mar. 1990, Project Closed
        ブレオマイシン;抗ガン剤の作用機作;DNA切断分子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01649509/
      • CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNX
        Grant-in-Aid for Scientific Research (C)
        Basic Section 50010:Tumor biology-related
        Chiba Cancer Center (Research Institute)
        上久保 靖彦
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        RUNX;転移;抗腫瘍免疫
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07168/
      • Development of transcription therapy for skin cell rejuvenation using design-on-demand artificial transcription factors
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
        Kyoto University
        ナマシヴァヤム パンディアン
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02607/
      • Development of transcription therapy for skin cell rejuvenation using design-on-demand artificial transcription factors
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
        Kyoto University
        ナマシヴァヤム パンディアン
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27298/
      • A novel strategy for molecular diagnosis and prophylactic approach to non-syndromic cleft palate
        Grant-in-Aid for Scientific Research (B)
        Basic Section 57070:Developmental dentistry-related
        Osaka University
        山城 隆
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        口蓋裂;Stat3;p63;ペリダーム;器官培養;環境因子;遺伝因子;PIポリアミド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21497/

      External funds: others

      • 遺伝子発現制御と塩基配列認識を基盤とするライブラリー創薬支援 (2021年度分)
        文部科学省, 医療研究開発推進事業費補助金
        From 01 Apr. 2021, To 31 Mar. 2022
        代表
      • 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 （平成26年度分）
        国際共同研究事業国際化学研究協力事業
        From 01 Apr. 2014, To 31 Mar. 2015
        杉山　弘
      • 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 （平成27年度分）
        国際共同研究事業国際化学研究協力事業
        From 01 Apr. 2015, To 31 Mar. 2016
        杉山　弘
      • 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 （平成28年度分）
        国際共同研究事業国際化学研究協力事業
        From 01 Apr. 2016, To 31 Mar. 2017
        杉山　弘
      • 遺伝子発現制御と塩基配列認識を基盤とするライブラリー創薬支援 （平成29年度分）
        医療研究開発推進事業費補助金
        From 01 Apr. 2017, To 31 Mar. 2018
        杉山 弘
      • 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 （平成29年度分）
        国際共同研究事業国際化学研究協力事業
        From 01 Apr. 2017, To 31 Mar. 2018
        杉山 弘
      • 遺伝子発現制御と塩基配列認識を基盤とするライブラリー創薬支援 （平成30年度分）
        医療研究開発推進事業費補助金
        From 01 Apr. 2018, To 31 Mar. 2019
        杉山 弘
      • 遺伝子発現制御と塩基配列認識を基盤とするライブラリー創薬支援 （2019年度分）
        医療研究開発推進事業費補助金
        From 01 Apr. 2019, To 31 Mar. 2020
        杉山　弘
      • 遺伝子発現制御と塩基配列認識を基盤とするライブラリー創薬支援 （2020年度分）
        医療研究開発推進事業費補助金
        From 01 Apr. 2020, To 31 Mar. 2021
        杉山　弘
      list
        Last Updated :2025/05/27

        Education

        Teaching subject(s)

        • From Apr. 2011, To Mar. 2012
          生物化学ゼミナールⅠA
          Spring, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学ゼミナールⅠB
          Fall, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学ゼミナールⅠC
          Spring, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学ゼミナールⅠD
          Fall, 理学研究科
        • From Apr. 2011, To Mar. 2012
          ケミカルバイオロジー概論
          Spring, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学演習ⅠA
          Spring, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学演習ⅠB
          Fall, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学演習ⅠC
          Spring, 理学研究科
        • From Apr. 2011, To Mar. 2012
          生物化学演習ⅠD
          Fall, 理学研究科
        • From Apr. 2011, To Mar. 2012
          ケミカル・バイオロジー
          Spring, 理学部
        • From Apr. 2011, To Mar. 2012
          Introduction to Modern Chemistry
          Spring, 全学共通科目
        • From Apr. 2011, To Mar. 2012
          化学課題研究１６
          Year-long, 理学部
        • From Apr. 2012, To Mar. 2013
          Chemical Biology
          Spring, 理学部
        • From Apr. 2012, To Mar. 2013
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2012, To Mar. 2013
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2012, To Mar. 2013
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2013, To Mar. 2014
          Chemical Biology
          Spring, 理学部
        • From Apr. 2013, To Mar. 2014
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2013, To Mar. 2014
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2013, To Mar. 2014
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Chemical Biology
          Spring, 理学部
        • From Apr. 2014, To Mar. 2015
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2014, To Mar. 2015
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2014, To Mar. 2015
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Course in Molecular Biology and Biochemistry
          Fall, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2015, To Mar. 2016
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Biochemistry II
          Spring, 理学部
        • From Apr. 2015, To Mar. 2016
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2015, To Mar. 2016
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2015, To Mar. 2016
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2016, To Mar. 2017
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2016, To Mar. 2017
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Course in Molecular Biology and Biochemistry
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Biochemistry II
          Spring, 理学部
        • From Apr. 2016, To Mar. 2017
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2016, To Mar. 2017
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2017, To Mar. 2018
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2017, To Mar. 2018
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Biochemistry II
          Spring, 理学部
        • From Apr. 2017, To Mar. 2018
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2017, To Mar. 2018
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2018, To Mar. 2019
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2018, To Mar. 2019
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Course in Molecular Biology and Biochemistry
          Fall, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Biochemistry II
          Spring, 理学部
        • From Apr. 2018, To Mar. 2019
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2018, To Mar. 2019
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2018, To Mar. 2019
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2019, To Mar. 2020
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2019, To Mar. 2020
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Biochemistry II
          Spring, 理学部
        • From Apr. 2019, To Mar. 2020
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2019, To Mar. 2020
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2019, To Mar. 2020
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2020, To Mar. 2021
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2020, To Mar. 2021
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Course in Molecular Biology and Biochemistry
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Biochemistry II
          Spring, 理学部
        • From Apr. 2020, To Mar. 2021
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2020, To Mar. 2021
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2021, To Mar. 2022
          Special study course II (Chemistry) 16
          Year-long, 理学部
        • From Apr. 2021, To Mar. 2022
          Principles of Chemical Biology
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Biochemistry II
          Spring, 理学部
        • From Apr. 2021, To Mar. 2022
          Biochemistry IV
          Spring, 理学部
        • From Apr. 2021, To Mar. 2022
          Seminar on Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biochemistry IA
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biochemistry IB
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biochemistry IC
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biochemistry ID
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Exercises in Biochemistry
          Fall, 理学部

        Participation in PhD Defense

        • Investigating Advanced Properties of Modular DNAs as Biohybrid Catalyst and Aptamer
          Yum Ji Hye, Graduate School of Science, Chief Examiner
          23 Mar. 2022
        • Biomolecular nanotechnology-based approaches to investigate nucleic acid interactions
          SHUBHAM MISHRA, Graduate School of Science, Chief Examiner
          23 Mar. 2022
        • DNA based Photo-controllable Extracellular Matrix-like Scaffolds to Understand and Control Cell Behaviour
          SOUMYA SETHI, Graduate School of Science, Chief Examiner
          23 Mar. 2022
        list
          Last Updated :2025/05/27

          Administration

          School management (title, position)

          • From 01 Jan. 2020, To 31 Dec. 2020
            国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員
          • From 01 Jan. 2020, To 31 Dec. 2021
            国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員

          Faculty management (title, position)

          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科化学専攻副専攻長
          • From 01 Apr. 2016, To 31 Mar. 2017
            理学部・教育委員会委員
          • From 01 Apr. 2016, To 31 Mar. 2017
            理学部・教育委員会　少人数担任委員会委員
          • From 01 Apr. 2017, To 31 Mar. 2018
            理学部・教育委員会委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            理学部・教育委員会　少人数担任委員会委員
          • From 01 Apr. 2017, To 31 Mar. 2018
            理学研究科会議構成員
          • From 01 Apr. 2017, To 31 Mar. 2018
            理学部・教育委員会　少人数担任委員会委員
          • From 01 Apr. 2018, To 31 Mar. 2019
            理学研究科将来計画委員会委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            理学研究科将来計画委員会委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            理学研究科研究科会議構成員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科将来計画委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科自己点検・評価委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科大学院教育常任委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科大学院教育教務委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科研究科会議構成員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科専攻長会議構成員
          list
            Last Updated :2025/05/27

            Academic, Social Contribution

            Committee Memberships

            • From May 2021, To Apr. 2023
              会長, 近畿化学協会
            • From 2017, To Present
              Associate Editor, Bull. Chem. Soc. J.
            • From 2016, To Present
              Editorial Advisory Board, Cell, Chemical Biology
            • From 2014, To Present
              Editorial Board, Scientific Reports
            • From May 2010, To Apr. 2023
              理事, 近畿化学協会
            • From 2009, To Present
              Editional Board, J. Nucleic Acids.
            • From 2008, To Present
              理事, 日本光医学・光生物学会
            • From 2005, To Present
              Editorial Advisory Board, ChemBioChem.
            • From Apr. 2013, To Mar. 2016
              主任研究員, 日本学術振興会学術システムセンター
            • From 2012, To 2016
              Associate Editor, Biomaterials Science
            • From 2011, To 2014
              Editorial Board, The Chemical Record
            • From 2011, To 2014
              Editorial Advisory Board, J. Med. Chem.
            • From 2009, To 2014
              Editorial Advisory Board, J. Am. Chem. Soc.

            Academic Contribution

            • 人工遺伝子スイッチライブラリー（研究者と立ち話）
              京都大学, From 22 Sep. 2018
            • 人工遺伝子スイッチでがんを治す（研究者と立ち話）
              京都大学, From 30 Sep. 2017
            • 遺伝子スイッチでガンを治す（研究者と立ち話）
              京都大学, From 18 Sep. 2016
            • 人工遺伝子スイッチを創る（研究者と立ち話）
              京都大学, From 04 Oct. 2015
            • DNAオリガミを使ってできること（研究者と立ち話）
              京都大学, From 28 Sep. 2014

            Social Contribution

            • 遺伝子発現を観て操る
              Official expert
              京都大学, アカデミックデイ2019, From 15 Sep. 2019

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