基本情報

学部兼担

• 理学部

学内兼務

• 高等研究院, 物質－細胞統合システム拠点, 連携主任研究者

所属学協会

• アメリカ化学会
• 日本ケミカルバイオロジー学会
• 日本生物物理学会
• 日本分子生物学会
• 近畿化学協会
• 有機合成化学協会
• 日本癌学会
• 日本薬学会
• 日本化学会
• 日本光医学・光生物学会

学位

• 工学修士(京都大学)
• 工学博士(京都大学)

経歴

• 自 2022年04月, 至 現在

  物質ー細胞統合システム拠点, 特任教授
• 自 2008年04月, 至 2018年03月

  京都大学, 物質-細胞統合システム拠点, 主任研究員 併任
• 自 2003年04月, 至 2022年03月

  京都大学, 大学院理学研究科, 教授
• 自 1999年04月, 至 2003年03月

  東京医科歯科大学, 生体材料工学研究所, 教授
• 自 1996年11月, 至 1999年03月

  東京医科歯科大学, 医用器材研究所, 教授
• 自 1993年03月, 至 1996年10月

  京都大学, 工学部 合成化学科, 助教授
• 自 1987年04月, 至 1993年02月

  京都大学, 工学部 合成化学科, 助手
• 自 1986年04月, 至 1987年03月

  米国ヴァージニア大学, 日本学術振興会特別研究員
• 自 1984年04月, 至 1986年03月

  米国ヴァージニア大学, 博士研究員

プロフィール

• プロフィール

  核酸についてケミカルバイオロジー研究を進めている。有機合成化学、分子生物学、分子シュミレーション手法を用いて、遺伝子発現の化学的な原理の解明を目指している。
  
  現在、京都大学で進めている主な研究テーマは、（１）人工遺伝子スイッチの設計と評価、（２）テーラーメイド抗がん剤の開発、（３）DNAナノ構造体を用いた生体分子の機能評価、（４）DNAを基盤とした不斉触媒の開発、が挙げられる。

ID,URL

• J-Global ID

  201401010422554614

• 外部リンク

  https://www.namasivayam.icems.kyoto-u.ac.jp/visitingprof

関連Webサイト

• http://kuchem.kyoto-u.ac.jp/chembio/

researchmap URL

• https://researchmap.jp/7000009721

研究

研究テーマ・研究概要

• 研究テーマ

  DNAを中心としたケミカルバイオロジー研究

• 研究概要

  杉山グループでは核酸の生物有機化学を行っている。合成化学と分子生物学の手法を用いて、核酸の分子認識、反応性と構造について研究している。核酸を物質としてこのように一般的にそして基本的に研究しているグループは他にない。グループでは以下の領域での研究を具体的に行っている。DNAの塩基のアルキル化、水素引き抜き、電子移動によるDNAの修飾についての分子機構の解明。抗癌性抗生物質の作用機構の理解に基づいた配列特異的なアルキル化剤の開発。DNAの局所構造の解析法の開発。細胞の分化や病気の治療を目指した人工遺伝子スイッチの開発を長期的な目標としている。

研究キーワード

• 核酸化学
• ケミカルバイオロジー

研究分野

• ナノテク・材料, 生体化学

論文

• Cancer Accumulation and Anticancer Activity of "CROX (Cluster Regulation of RUNX)" PIP in HER2-Positive Gastric Cancer Evaluated by Chicken Egg Cancer Model.

  Tatsuya Masuda; Takayoshi Watanabe; Yasutoshi Tatsumi; Jason Lin; Kazuhiro Okumura; Toshinori Ozaki; Hiroshi Sugiyama; Yasuhiko Kamikubo

  Cancer medicine, 2025年04月

  
• NIR-Induced Photoswitching Hybrid DNA Nanoconstruct-Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

  Thanapat Pongkulapa; Ji Hye Yum; Callan D. Mcloughlin; Brandon Conklin; Tomotaka Kumagai; Li Ling Goldston; Hiroshi Sugiyama; Soyoung Park; Ki-Bum Lee

  SMALL, 2025年02月25日

  
• Evaluation of anti-cancer activity of the inhibitors against RUNX and p300 based on the CAM model

  Takayoshi Watanabe; Tatsuya Masuda; Yasutoshi Tatsumi; Utomo Rohmad; Hiroshi Sugiyama; Meiyanto Edy; Yasuhiko Kamikubo

  CANCER SCIENCE, 2025年01月

  
• Modulation of Excimer Formation and Photoexcitation Behaviour through DNA-Surfactant-Dye Supramolecular Assembly

  Dan Bai; Wenxuan Zhao; Huhu Feng; Hiroshi Sugiyama

  MACROMOLECULAR MATERIALS AND ENGINEERING, 2024年05月

  
• CROX (Cluster Regulation of RUNX) strategy against MYCN-amplified neuroblastoma through p53-mediated apoptosis

  Tatsuya Masuda; Yasutoshi Tatsumi; Takayoshi Watanabe; Toshinori Ozaki; Kazuma Nakatani; Ummi Zulfin; Yusuke Suenaga; Yoshitaka Hippo; Hiroshi Sugiyama; Yasuhiko Kamikubo

  CANCER SCIENCE, 2024年03月

  
• The use of Chorioallantoic membrane from fertilized chicken eggs as an anticancer drug evaluation system

  Takayoshi Watanabe; Tatsuya Masuda; Yasutoshi Tatsumi; Utomo Rohmad; Zulfin Ummi; Meiyanto Edy; Yoshitaka Hippo; Hiroshi Sugiyama; Yasuhiko Kamikubo

  CANCER SCIENCE, 2024年03月

  
• RNA G-quadruplex in functional regulation of noncoding RNA: Challenges and emerging opportunities

  Vinodh J. Sahayasheela; Hiroshi Sugiyama

  CELL CHEMICAL BIOLOGY, 2024年01月18日

  
• Follow your interests and use anything for research

  Hiroshi Sugiyama

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2024年

  
• Nucleic acid assembled semiconducting materials: Rational design, structure-property modulation, and performance evaluations

  Dan Bai; Wenxuan Zhao; Huhu Feng; Hiroshi Sugiyama

  APL MATERIALS, 2023年10月01日

  
• DNA Methylation Modification Patterns Identify Distinct Prognosis and Responses to Immunotherapy and Targeted Therapy in Renal Cell Carcinoma

  Dan Bai; Yan Cheng; Xiaolan Lu; Ganesh Pandian Namasivayam; Hiroshi Sugiyama

  FRONTIERS IN BIOSCIENCE-LANDMARK, 2023年09月

  
• Novel Auger-Electron-Emitting 191Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

  Honoka Obata; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Kaori Hashiya; Hayato Ikeda; Masatoshi Itoh; Katsuyuki Minegishi; Kotaro Nagatsu; Mikako Ogawa; Toshikazu Bando; Hiroshi Sugiyama; Ming-Rong Zhang

  Pharmaceuticals, 2023年10月27日

  
• Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.

  Kenta Kurayoshi; Yusuke Takase; Masaya Ueno; Kumiko Ohta; Kyoko Fuse; Shuji Ikeda; Takayoshi Watanabe; Yuki Nishida; Shin-Ichi Horike; Kazuyoshi Hosomichi; Yuichi Ishikawa; Yuko Tadokoro; Masahiko Kobayashi; Atsuko Kasahara; Yongwei Jing; Mahmoud I Shoulkamy; Makiko Meguro-Horike; Kensuke Kojima; Hitoshi Kiyoi; Hiroshi Sugiyama; Hiroki Nagase; Atsushi Tajima; Atsushi Hirao

  Cell Death & Disease, 2023年09月, 査読有り

  
• Artificial intelligence in microbial natural product drug discovery: current and emerging role

  Vinodh J. Sahayasheela; Manendra B. Lankadasari; Vipin Mohan Dan; Syed G. Dastager; Ganesh N. Pandian; Hiroshi Sugiyama

  Natural Product Reports, 2022年

  この論文にアクセスする：

  
• Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator: MitoScript

  Yang, L.; Rathnam, C.; Hidaka, T.; Hou, Y.; Conklin, B.; P; ian, G.N.; Sugiyama, H.; Lee, K.-B.

  Nano Letters, 2022年

  
• Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma

  Dan Bai; Huhu Feng; Jiajun Yang; Aiping Yin; Xiao Lin; Airong Qian; Hiroshi Sugiyama

  Molecular Therapy - Nucleic Acids, 2021年09月03日

  この論文にアクセスする：

  
• Controlling the function of genes and biologically active nucleic acids

  Makiya Nishikawa; Hiroshi Sugiyama

  Advanced Drug Delivery Reviews, 2019年07月01日

  
• DNAオリガミを用いた直行性を有する転写デバイスの合理的設計

  増渕 岳也; 遠藤 政幸; 飯塚 怜; 井口 彩香; Yoon Dong; 関口 哲志; Qi Hao; 飯沼 良介; 宮薗 侑也; 庄子 習一; 船津 高志; 杉山 弘; 原田 慶恵; 上田 卓也; 多田隈 尚史

  生命科学系学会合同年次大会, 2017年12月

  
• RUNX1によるE-selectinの転写制御は血管ニッチにおいて白血病の治療標的となる

  徳重 智恵子; 森田 剣; 前田 信太郎; 清瀬 大樹; 能浦 三奈; 片岡 竜貴; 杉山 弘; 上久保 靖彦; 足立 壮一

  日本癌学会総会記事, 2017年09月

  
• Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals

  Katsuhiko Abe; Haruhiko Eki; Yuki Hirose; Soyoung Park; Shanmugavel Chinnathambi; Ganesh Pandian Namasivayam; Kazuki Takeda; Hiroshi Sugiyama; Masayuki Endo

  Molecules, 2024年10月01日

  
• Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands

  Deepak Karna; Lin Liang; Grinsun Sharma; Shankar Mandal; Sefan Asamitsu; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Hanbin Mao

  Nucleic Acids Research, 2024年09月01日

  
• Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation.

  T. Bando; A. Narita; I. Saito; H. Sugiyama

  Nucleic acids research. Supplement (2001), 2001年

  
• A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures

  Mitsuharu Ooga; Vinodh Sahayasheela; Yuki Hirose; Daisuke Sasaki; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chemical Communications, 2024年

  
• Integrated analysis of immune-related gene subtype and immune index for immunotherapy in clear cell renal cell carcinoma

  Dan Bai; Suna Chen; Huhu Feng; Aiping Yin; Juncheng Lu; Yiran Ma; Hiroshi Sugiyama

  Pathology Research and Practice, 2021年09月01日

  
• Tropylium derivatives as new entrants that sense quadruplex structures

  Daisuke Hori; Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park

  Bulletin of the Chemical Society of Japan, 2021年07月01日

  この論文にアクセスする：

  
• Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs

  Wen Ann Wee; Ji Hye Yum; Shingo Hirashima; Hiroshi Sugiyama; Soyoung Park

  RSC Chemical Biology, 2021年06月01日

  この論文にアクセスする：

  
• Folding RNA–Protein Complex into Designed Nanostructures

  Tomonori Shibata; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito

  Methods in Molecular Biology, 2021年

  
• Histidine-conjugated DNA as a biomolecular depot for metal ions

  Soyoung Park; Haruka Matsui; Koyuki Fukumoto; Ji Hye Yum; Hiroshi Sugiyama

  RSC Advances, 2020年03月06日

  
• Telomeric quadruplexes as therapeutic targets

  Sefan Asamitsu; Norifumi Shioda; Hiroshi Sugiyama

  Annual Reports in Medicinal Chemistry, 2020年01月01日

  
• Epigenetic drug discovery by artificial genetic switches

  Toshikazu Bando; Hiroshi Sugiyama

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2020年

  
• Chb-M', an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in p53-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo.

  Yuki Hirose; Shinsuke Sato; Kaori Hashiya; Mitsuharu Ooga; Toshikazu Bando; Hiroshi Sugiyama

  Journal of medicinal chemistry, 2024年05月27日

  
• Structural Studies of a Complex of a CAG/CTG Repeat Sequence-Specific Binding Molecule and A-A-Mismatch-Containing DNA.

  Katsuhiko Abe; Yuki Hirose; Tomotaka Kumagai; Kaori Hashiya; Kumi Hidaka; Tomoko Emura; Toshikazu Bando; Kazuki Takeda; Hiroshi Sugiyama

  JACS Au, 2024年05月27日

  
• Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells.

  Yuki Hirose; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Journal of medicinal chemistry, 2023年09月14日

  
• Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effect

  Yusuke Kawamoto; You Wu; Soyoung Park; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura

  Chemical Communications, 2024年

  
• DNA折り紙上の異なった方式による遺伝子転写ナノデバイスの理論的な設計(Rational design of orthogonal gene transcription nano device on DNA origami)

  増渕 岳也; 多田隈 向史; 飯塚 怜; 遠藤 政幸; 船津 高志; 杉山 弘; 原田 慶恵; 上田 卓也

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月

  
• Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

  Hirohito Kubota; Kana Furuichi; Tatsuya Masuda; Toshiya Tatsuta; Hidefumi Hiramatsu; Junko Takita; Sugiyama Hiroshi; Souichi Adachi; Yasuhiko Kamikubo

  Blood, 2019年11月13日

  
• 遺伝子スイッチ法を用いたRUNXクラスター制御がもたらす強力な抗癌作用(RUNX cluster regulation by GENE SWITCH triggers a profound tumor regression of diverse origins)

  Morita Ken; Suzuki Kensho; Maeda Shintaro; Mitsuda Yoshihide; Tokushige Chieko; Kashiwazaki Gengo; Taniguchi Junichi; Maeda Rina; Noura Mina; Hirata Masahiro; Kataoka Tatsuki; Kiyos Hiroki; Tokumasu Mayu; Matsuo Hidemasa; Matsuo Akihiko; Tanaka Sunao; Okuno Yasushi; Muto Manabu; Naka Kazuhito; Ito Kosei; Kitamura Toshio; Kaneda Yasufumi; Liu Paul P.; Bando Toshikazu; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi

  臨床血液, 2017年09月

  
• RUNX1によるE-selectinの転写制御は血管ニッチにおいて白血病の治療標的となる(RUNX1 enhances leukemia cell engraftment in the vascular niche through up-regulating E-selectin)

  Tokushige Chieko; Morita Ken; Maeda Shintaro; Kiyose Hiroki; Noura Mina; Bando Toshikazu; Hirata Masahiro; Kataoka Tatsuki; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi

  臨床血液, 2017年09月

  
• 急性骨髄性白血病においてRUNX1、p53、CBFBは細胞自律性のフィードバックループを構成する(Cell-autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells)

  Noura Mina; Morita Ken; Tokushige Chieko; Maeda Shintaro; Bando Toshikazu; Sugiyama Hiroshi; Kamikubo Yasuhiko; Adachi Souichi

  臨床血液, 2017年09月

  
• Nucleic acid‐based small molecules as targeted transcription therapeutics for immunoregulation

  Dan Bai; Reihane Ziadlou; Thangavel Vaijayanthi; Subramani Karthikeyan; Shanmugavel Chinnathambi; Anutthaman Parthasarathy; Li Cai; Marie‐Charlotte Brüggen; Hiroshi Sugiyama; Ganesh N. Pandian

  Allergy, 2023年12月06日

  
• Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs

  Thangavel Vaijayanthi; Ganesh N. Pandian; Hiroshi Sugiyama

  Advanced Therapeutics, 2023年07月

  
• A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models.

  Susumu Ikenoshita; Kazuya Matsuo; Yasushi Yabuki; Kosuke Kawakubo; Sefan Asamitsu; Karin Hori; Shingo Usuki; Yuki Hirose; Toshikazu Bando; Kimi Araki; Mitsuharu Ueda; Hiroshi Sugiyama; Norifumi Shioda

  The Journal of clinical investigation, 2023年09月14日

  
• Structural Expansion of Catalytic RNA Nanostructures through Oligomerization of a Cyclic Trimer of Engineered Ribozymes

  Mst. Ayesha Siddika; Hiroki Oi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Molecules, 2023年09月06日

  
• Isothermal self-assembly of multicomponent and evolutive DNA nanostructures

  Caroline Rossi-Gendron; Farah El Fakih; Laura Bourdon; Koyomi Nakazawa; Julie Finkel; Nicolas Triomphe; Léa Chocron; Masayuki Endo; Hiroshi Sugiyama; Gaëtan Bellot; Mathieu Morel; Sergii Rudiuk; Damien Baigl

  Nature Nanotechnology, 2023年07月31日

  
• Two-Dimensional DNA Origami Lattices Assembled on Lipid Bilayer Membranes

  Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo

  Methods in Molecular Biology, 2023年05月12日

  
• Mitochondria and G-quadruplex evolution: an intertwined relationship

  Vinodh J. Sahayasheela; Zutao Yu; Takuya Hidaka; Ganesh N. Pandian; Hiroshi Sugiyama

  Trends in Genetics, 2023年01月, 査読有り, 最終著者, 責任著者

  この論文にアクセスする：

  
• Corrigendum to "Chlorambucil-conjugated PI-polyamide (Chb-M'), a transcription inhibitor of the RUNX family, has anti-tumor activity against SHH-type medulloblastoma with p53 mutation" [Biochem. Biophys. Res. Commun. 620 (10 September 2022) 150-157].

  Yasuzumi Matsui; Yohei Mineharu; Yuki Noguchi; Etsuko Yamamoto Hattori; Hirohito Kubota; Masahiro Hirata; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo

  Biochemical and biophysical research communications, 2023年05月14日

  
• Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition

  Takayoshi Watanabe; Ken-ichi Shinohara; Yoshinao Shinozaki; Syota Uekusa; Xiaofei Wang; Nobuko Koshikawa; Kiriko Hiraoka; Takahiro Inoue; Jason Lin; Toshikazu Bando; Hiroshi Sugiyama; Hiroki Nagase

  Advanced Techniques in Biology & Medicine, 2015年

  
• Single-Molecule Visualization of B–Z Transition in DNA Origami Using High-Speed AFM

  Masayuki Endo; Hiroshi Sugiyama

  Methods in Molecular Biology, 2023年03月10日

  
• Substitution to hydrophobic linker and formation of host-guest complex enhanced the effect of synthetic transcription factor made of pyrrole-imidazole polyamide.

  Junnosuke Hatanaka; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Bioorganic & medicinal chemistry, 2023年03月01日, 査読有り

  
• Twelve Colors of Streptavidin-Fluorescent Proteins (SA-FPs): A Versatile Tool to Visualize Genetic Information in Single-Molecule DNA.

  Yu Jin; Jaeyoung Bae; Tehee Yurie Kim; Hyeseung Hwang; Taesoo Kim; Myungheon Yu; Hyesoo Oh; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Kyubong Jo

  Analytical chemistry, 2022年12月06日

  
• N-terminal Cationic Modification of Linear Pyrrole-Imidazole Polyamide Improves Its Binding to DNA.

  Junnosuke Hatanaka; Yuki Hirose; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chembiochem : a European journal of chemical biology, 2022年07月19日

  
• Author Correction: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.

  Etsuko Yamamoto Hattori; Tatsuya Masuda; Yohei Mineharu; Masamitsu Mikami; Yukinori Terada; Yasuzumi Matsui; Hirohito Kubota; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Shuji Ikeda; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo

  Communications biology, 2022年09月27日

  
• A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.

  Etsuko Yamamoto Hattori; Tatsuya Masuda; Yohei Mineharu; Masamitsu Mikami; Yukinori Terada; Yasuzumi Matsui; Hirohito Kubota; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Shuji Ikeda; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo

  Communications biology, 2022年09月09日

  この論文にアクセスする：

  
• RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.

  Sefan Asamitsu; Yasushi Yabuki; Kazuya Matsuo; Moe Kawasaki; Yuki Hirose; Gengo Kashiwazaki; Anandhakumar Chandran; Toshikazu Bando; Dan Ohtan Wang; Hiroshi Sugiyama; Norifumi Shioda

  Science advances, 2023年02月24日

  
• Photocontrolled DNA nanotubes as stiffness tunable matrices for controlling cellular behavior

  Soumya Sethi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Nanoscale, 2023年

  この論文にアクセスする：

  
• Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes

  Mst. Ayesha Siddika; Takahiro Yamada; Risako Aoyama; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Molecules, 2022年11月28日

  
• Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation.

  Yasuzumi Matsui; Yohei Mineharu; Yuki Noguchi; Etsuko Yamamoto Hattori; Hirohito Kubota; Masahiro Hirata; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo

  Biochemical and biophysical research communications, 2022年09月10日, 査読有り

  
• RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors.

  Masamitsu Mikami; Tatsuya Masuda; Takuya Kanatani; Mina Noura; Katsutsugu Umeda; Hidefumi Hiramatsu; Hirohito Kubota; Tomoo Daifu; Atsushi Iwai; Etsuko Yamamoto Hattori; Kana Furuichi; Saho Takasaki; Sunao Tanaka; Yasuzumi Matsui; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Yasumichi Kuwahara; Tomoko Iehara; Hajime Hosoi; Yoichi Imai; Junko Takita; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo

  Molecules and cells, 2022年12月31日

  
• Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes

  Shankar Pandey; Sagun Jonchhe; Shubham Mishra; Tomoko Emura; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao

  The Journal of Physical Chemistry Letters, 2022年09月12日

  
• Box-shaped ribozyme octamer formed by face-to-face dimerization of a pair of square-shaped ribozyme tetramers

  Md Dobirul Islam; Kumi Hidaka; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Journal of Bioscience and Bioengineering, 2022年09月

  
• RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia.

  Tatsuya Masuda; Shintaro Maeda; Sae Shimada; Naoya Sakuramoto; Ken Morita; Asami Koyama; Kensho Suzuki; Yoshihide Mitsuda; Hidemasa Matsuo; Hirohito Kubota; Itaru Kato; Kuniaki Tanaka; Junko Takita; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Souichi Adachi; Hideyo Hirai; Shuichi Mizuta; Kazuhito Naka; Yoichi Imai; Shinya Kimura; Hiroshi Sugiyama; Yasuhiko Kamikubo

  Cancer science, 2022年02月, 査読有り, 責任著者

  この論文にアクセスする：

  
• 1PS042 多分子キネシン間の協調性は運搬物を効率的に長距離輸送するのに重要である(日本生物物理学会第50回年会(2012年度))

  Miyazono Yuya; Endo Masayuki; Ueda Takuya; Sugiyama Hiroshi; Harada Yoshie; Tadakuma Hisashi

  生物物理, 2012年

  
• PD20 DNA STRAND SCISSION BY NEOCARZINOSTATIN : REACTION OF SELF-COMPLEMENTARY OLIGONUCLOETIDE

  Kawabata Hiroshi; Sugiyama Hiroshi; Takeshita Hiroshi; Matsuura Teruo; Saito Isao

  International Symposium on the Chemistry of Natural Products, 1988年05月29日

  
• Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain

  Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Tatsuya Segawa; Jean-Pierre Bellier; Kumi Hidaka; Hiroshi Sugiyama; Daita Kaneda; Yoshio Hashizume; Hiroyasu Akatsu; Kunio Miki; Akiko Kita; Douglas G. Walker; Kazuhiro Irie; Ikuo Tooyama

  ACS Chemical Neuroscience, 2021年08月31日, 査読有り

  
• Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model

  Madhu Malinee; Ganesh Namasivayam Pandian; Hiroshi Sugiyama

  Cell Chemical Biology, 2022年02月, 査読有り

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• SLD2 OXIDATIVE STRAND SCISSION OF DNA

  Matsuura Teruo; Saito Isao; Sugiyama Hiroshi; Morii Takashi

  International Symposium on the Chemistry of Natural Products, 1988年05月29日

  
• DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion

  Shengtao Yao; Yongyun Chang; Zanjing Zhai; Hiroshi Sugiyama; Masayuki Endo; Weiping Zhu; Yufang Xu; Yangyang Yang; Xuhong Qian

  ACS Appl. Mater. Interfaces, 2022年04月29日, 査読有り

  
• 1M1524 DNA-kinesinハイブリッド・ナノマシンの構築(分子モーター2,第49回日本生物物理学会年会)

  Miyazono Yuya; Endo Masayuki; Ueda Takuya; Sugiyama Hiroshi; Harada Yoshie; Tadakuma Hisashi

  生物物理, 2011年

  
• An informatics approach to distinguish RNA modifications in nanopore direct RNA sequencing.

  Soundhar Ramasamy; Shubham Mishra; Surbhi Sharma; Sangamithirai Subramanian Parimalam; Thangavel Vaijayanthi; Yoto Fujita; Basavaraj Kovi; Hiroshi Sugiyama; Ganesh N Pandian

  Genomics, 2022年04月20日, 査読有り

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• Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses

  Soumya Sethi; Hiroshi Sugiyama; Masayuki Endo

  ChemBioChem, 2022年03月18日, 査読有り

  
• A Hexameric Ribozyme Nanostructure Formed by Double‐Decker Assembly of a Pair of Triangular Ribozyme Trimers

  Kai Yu; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  ChemBioChem, 2022年03月18日, 査読有り

  
• Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity

  Sagun Jonchhe; Shankar Pandey; Christian Beneze; Tomoko Emura; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao

  Nucleic Acids Research, 2022年01月25日, 査読有り

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• 2P-112 BrG置換されたヒトテロメアDNAの単 : 分子FRET計測に基づくG-quadruplex立体構造の考察(核酸・構造物性,第46回日本生物物理学会年会)

  Okamoto Kenji; Sannohe Yuta; Mashimo Tomoko; Sugiyama Hiroshi; Terazima Masahide

  生物物理, 2008年

  
• Strong and Specific Recognition of CAG/CTG Repeat DNA (5'-dWGCWGCW-3') by a Cyclic Pyrrole-Imidazole Polyamide.

  Yuki Hirose; Tomo Ohno; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chembiochem : a European journal of chemical biology, 2022年01月19日, 査読有り

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• Enhanced Immunostimulatory Activity of Covalent DNA Dendrons

  Yusuke Kawamoto; Wen Liu; Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura

  ChemBioChem, 2021年12月08日, 査読有り

  
• Comparative analysis of mitochondrial genomes in different species reveals the evolution of G-quadruplexes

  Hiroshi Sugiyama; Vinodh Sahayasheela; Zutao Yu; Ganesh Pandian

  2021年12月01日

  
• Sequence-Specific Control of Using Programmable Synthetic Gene Switches Called MITO-PIPs

  Takuya Hidaka; Hiroshi Sugiyama; Ganesh N. Pandian

  Methods in Molecular Biology, 2021年, 査読有り

  
• Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation

  Ganesh N. Pandian; Hiroshi Sugiyama

  Cell-Inspired Materials and Engineering, 2021年

  
• Photo-Controllable Phase Transition of Arylazopyrazole-Conjugated Oligonucleotides

  Takuya Hidaka; Wen Ann Wee; Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park

  Bioconjugate Chemistry, 2021年10月20日, 査読有り

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• Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs

  Satoru Ide; Asuka Sasaki; Yusuke Kawamoto; Toshikazu Bando; Hiroshi Sugiyama; Kazuhiro Maeshima

  Epigenetics & Chromatin, 2021年12月, 査読有り

  
• Non‐invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polymer

  Soumya Sethi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Angewandte Chemie International Edition, 2021年09月06日, 査読有り

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• Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.

  Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama

  Cell chemical biology, 2022年02月24日, 査読有り

  
• RUNX inhibitor suppresses graft‐versus‐host disease through targeting RUNX‐NFATC2 axis

  Hirohito Kubota; Tatsuya Masuda; Mina Noura; Kana Furuichi; Hidemasa Matsuo; Masahiro Hirata; Tatsuki R. Kataoka; Hidefumi Hiramatsu; Takahiro Yasumi; Tatsutoshi Nakahata; Yoichi Imai; Junko Takita; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo

  eJHaem, 2021年08月, 査読有り

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• HBD1 protein with a tandem repeat of two HMG-box domains is a DNA clip to organize chloroplast nucleoids in Chlamydomonas reinhardtii

  Mari Takusagawa; Yusuke Kobayashi; Yoichiro Fukao; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Takashi Hamaji; Yoshinobu Kato; Isamu Miyakawa; Osami Misumi; Toshiharu Shikanai; Yoshiki Nishimura

  Proceedings of the National Academy of Sciences, 2021年05月18日, 査読有り

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• Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways.

  Ming Wang; Xudong Ma; Kang Zhou; Huijuan Mao; Jiachun Liu; Xuqiong Xiong; Xiaoyin Zhao; Suresh Narva; Yoshimasa Tanaka; Yanling Wu; Chuanxin Guo; Hiroshi Sugiyama; Wen Zhang

  Journal of medicinal chemistry, 2021年05月05日, 査読有り

  
• Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment.

  Rina Maeda; Toshikazu Bando; Hiroshi Sugiyama

  Chembiochem : a European journal of chemical biology, 2021年05月04日, 査読有り

  
• Targeted epigenetic modulation using a DNA-based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells.

  Jin-A Lee; Jieun An; Junichi Taniguchi; Gengo Kashiwazaki; Ganesh N Pandian; Nazia Parveen; Tong Mook Kang; Hiroshi Sugiyama; Debojyoti De; Kyeong Kyu Kim

  Journal of cellular physiology, 2021年05月, 査読有り

  
• Flexible Assembly of Engineered Tetrahymena Ribozymes Forming Polygonal RNA Nanostructures with Catalytic Ability.

  Yuki Mori; Hiroki Oi; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Chembiochem : a European journal of chemical biology, 2021年04月19日, 査読有り

  
• Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin.

  Ji Hye Yum; Takumi Ishizuka; Koyuki Fukumoto; Daisuke Hori; Hong-Liang Bao; Yan Xu; Hiroshi Sugiyama; Soyoung Park

  ACS biomaterials science & engineering, 2021年04月12日, 査読有り

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• Landscape of immune cell infiltration in clear cell renal cell carcinoma to aid immunotherapy.

  Dan Bai; Huhu Feng; Jiajun Yang; Aiping Yin; Airong Qian; Hiroshi Sugiyama

  Cancer science, 2021年03月18日

  
• An RNA Triangle with Six Ribozyme Units Can Promote a Trans-Splicing Reaction through Trimerization of Unit Ribozyme Dimers

  Junya Akagi; Takahiro Yamada; Kumi Hidaka; Yoshihiko Fujita; Hirohide Saito; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Applied Sciences, 2021年03月14日

  
• Nucleosomes and Epigenetics from a Chemical Perspective.

  Yihong Feng; Masayuki Endo; Hiroshi Sugiyama

  Chembiochem : a European journal of chemical biology, 2021年02月15日

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• Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability.

  Bin Wang; Rizhao Pan; Weiping Zhu; Yufang Xu; Ye Tian; Masayuki Endo; Hiroshi Sugiyama; Yangyang Yang; Xuhong Qian

  Soft matter, 2021年02月15日

  
• Nanoscopic observation of a DNA crystal surface and its dynamic formation and degradation using atomic force microscopy.

  Haruhiko Eki; Katsuhiko Abe; Hiroshi Sugiyama; Masayuki Endo

  Chemical communications (Cambridge, England), 2021年02月14日

  
• Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole-Imidazole Polyamide.

  Yuki Hirose; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chemistry (Weinheim an der Bergstrasse, Germany), 2021年02月05日

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• Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.

  Tomoo Daifu; Masamitsu Mikami; Hidefumi Hiramatsu; Atsushi Iwai; Katsutsugu Umeda; Mina Noura; Hirohito Kubota; Tatsuya Masuda; Kana Furuichi; Saho Takasaki; Yuki Noguchi; Ken Morita; Toshikazu Bando; Masahiro Hirata; Tatsuki R Kataoka; Tatsutoshi Nakahata; Yasumichi Kuwahara; Tomoko Iehara; Hajime Hosoi; Junko Takita; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo

  Pediatric blood & cancer, 2021年02月

  
• Photocontrolled DNA Origami Assembly by Using Two Photoswitches.

  Shubham Mishra; Soyoung Park; Tomoko Emura; Hidaka Kumi; Hiroshi Sugiyama; Masayuki Endo

  Chemistry (Weinheim an der Bergstrasse, Germany), 2021年01月07日

  
• Construction of an optically controllable CRISPR-Cas9 system using a DNA origami nanostructure

  Katsuhiko Abe; Hiroshi Sugiyama; Masayuki Endo

  Chemical Communications, 2021年

  この論文にアクセスする：

  
• Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide.

  Yuki Araie; Shozo Ohtsuki; Soyoung Park; Makoto Nagaoka; Keisuke Umemura; Hiroshi Sugiyama; Kosuke Kusamori; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  Bioorganic & medicinal chemistry, 2021年01月01日

  
• CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.

  Sefan Asamitsu; Yasushi Yabuki; Susumu Ikenoshita; Kosuke Kawakubo; Moe Kawasaki; Shingo Usuki; Yuji Nakayama; Kaori Adachi; Hiroyuki Kugoh; Kazuhiro Ishii; Tohru Matsuura; Eiji Nanba; Hiroshi Sugiyama; Kohji Fukunaga; Norifumi Shioda

  Science advances, 2021年01月

  
• Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides.

  Takuya Hidaka; Hiroshi Sugiyama

  Chemical record (New York, N.Y.), 2020年12月17日

  
• Design, synthesis and anti-cancer activity of pyrrole-imidazole polyamides through target-downregulation of c-kit gene expression.

  Mi Zhang; Jing Liang; Shi-Kun Jiang; Ling Xu; Yan-Ling Wu; Annoor Awadasseid; Xiao-Yin Zhao; Xu-Qiong Xiong; Hiroshi Sugiyama; Wen Zhang

  European journal of medicinal chemistry, 2020年12月01日

  
• Direct Observation of Dynamic Interactions between Orientation-Controlled Nucleosomes in a DNA Origami Frame.

  Yihong Feng; Fumitaka Hashiya; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Chemistry (Weinheim an der Bergstrasse, Germany), 2020年11月26日

  
• DNA Alkylation of the RUNX-Binding Sequence by CBI-PI Polyamide Conjugates*.

  Rina Maeda; Shinji Ito; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chemistry (Weinheim an der Bergstrasse, Germany), 2020年11月17日, 査読有り

  
• Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.

  Nor Amira Khurshid Ahmed; Shern Kwok Lim; Ganesh N Pandian; Hiroshi Sugiyama; Chong Yew Lee; Boon Yin Khoo; Kit Lam Chan

  Molecular medicine reports, 2020年11月

  
• Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector.

  Takuya Hidaka; Yutaro Tsubono; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama

  Chemical communications (Cambridge, England), 2020年10月21日

  
• Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide.

  Yan Shan Ang; Toshikazu Bando; Hiroshi Sugiyama; Lin-Yue Lanry Yung

  Chembiochem : a European journal of chemical biology, 2020年10月15日, 査読有り

  
• A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres.

  Yutaro Tsubono; Yusuke Kawamoto; Takuya Hidaka; Ganesh N Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2020年10月14日

  
• Construction of a FRET System in a Double-Stranded DNA Using Fluorescent Thymidine and Cytidine Analogs.

  Shingo Hirashima; Hiroshi Sugiyama; Soyoung Park

  The journal of physical chemistry. B, 2020年10月08日

  
• Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions.

  Ji Hye Yum; Hiroshi Sugiyama; Soyoung Park

  Organic & biomolecular chemistry, 2020年09月21日

  
• Catalytic RNA nano-objects formed by self-assembly of group I ribozyme dimers serving as unit structures.

  Ryuji Kiyooka; Junya Akagi; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Journal of bioscience and bioengineering, 2020年09月, 査読有り

  
• DNA Nanostructures for Targeted Antimicrobial Delivery.

  Ioanna Mela; Pedro P Vallejo-Ramirez; Stanislaw Makarchuk; Graham Christie; David Bailey; Robert M Henderson; Hiroshi Sugiyama; Masayuki Endo; Clemens F Kaminski

  Angewandte Chemie (International ed. in English), 2020年07月27日, 査読有り

  
• DNA Nanostructures for Targeted Antimicrobial Delivery

  Ioanna Mela; Pedro P. Vallejo-Ramirez; Stanislaw Makarchuk; Graham Christie; David Bailey; Robert M. Henderson; Hiroshi Sugiyama; Masayuki Endo; Clemens F. Kaminski

  Angewandte Chemie, 2020年07月27日, 査読有り

  
• DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells.

  Tatsuoki Maezawa; Shozo Ohtsuki; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  Nanoscale, 2020年07月16日, 査読有り

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• Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles.

  Tomohiro Nobeyama; Kazuki Shigyou; Hirotaka Nakatsuji; Hiroshi Sugiyama; Naoko Komura; Hiromune Ando; Tsutomu Hamada; Tatsuya Murakami

  Langmuir : the ACS journal of surfaces and colloids, 2020年07月07日, 査読有り

  
• Development of Antibody-Oligonucleotide Complexes for Targeting Exosomal MicroRNA.

  Asako Yamayoshi; Shota Oyama; Yusuke Kishimoto; Ryo Konishi; Tsuyoshi Yamamoto; Akio Kobori; Hiroshi Harada; Eishi Ashihara; Hiroshi Sugiyama; Akira Murakami

  Pharmaceutics, 2020年06月12日, 査読有り

  
• X-ray crystal structure of a cyclic-PIP–DNA complex in the reverse-binding orientation

  Abe, Katsuhiko; Hirose, Yuki; Eki, Haruhiko; Takeda, Kazuki; Bando, Toshikazu; Endo, Masayuki; Sugiyama, Hiroshi

  Journal of the American Chemical Society, 2020年06月10日, 査読有り

  
• Duplex DNA Is Weakened in Nanoconfinement.

  Sagun Jonchhe; Shankar Pandey; Deepak Karna; Pravin Pokhrel; Yunxi Cui; Shubham Mishra; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao

  Journal of the American Chemical Society, 2020年06月03日, 査読有り

  
• Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications

  Soundhar Ramasamy; Vinodh J Sahayasheela; Zutao Yu; Takuya Hidaka; Li Cai; Hiroshi Sugiyama; Ganesh N. Pandian

  2020年05月20日

  
• Direct observation and analysis of TET-mediated oxidation processes in a DNA origami nanochip.

  Xiwen Xing; Shinsuke Sato; Nai-Kei Wong; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Nucleic acids research, 2020年05月07日, 査読有り

  この論文にアクセスする：

  
• N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.

  Callum J C Parr; Shunsuke Wada; Kenjiro Kotake; Shigetoshi Kameda; Satoshi Matsuura; Souhei Sakashita; Soyoung Park; Hiroshi Sugiyama; Yi Kuang; Hirohide Saito

  Nucleic acids research, 2020年04月06日, 査読有り

  この論文にアクセスする：

  
• A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.

  Zutao Yu; Mengting Ai; Soumen K Samanta; Fumitaka Hashiya; Junichi Taniguchi; Sefan Asamitsu; Shuji Ikeda; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Lyle Isaacs; Hiroshi Sugiyama

  Chemical communications (Cambridge, England), 2020年01月28日, 査読有り

  
• Advances in DNA Origami–Cell Interfaces

  Shubham Mishra; Yihong Feng; Masayuki Endo; Hiroshi Sugiyama

  ChemBioChem, 2020年01月15日, 査読有り

  
• A photocaged DNA nanocapsule for delivery and manipulation in cells.

  Yihong Feng; Takeshi Tohgasaki; Yasuyuki Shitomi; Hiroshi Sugiyama; Masayuki Endo

  Methods in enzymology, 2020年, 査読有り

  
• Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake.

  Shozo Ohtsuki; Yukako Shiba; Tatsuoki Maezawa; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  Nanoscale, 2019年12月28日, 査読有り

  
• Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillization.

  Tashiro R; Taguchi H; Hidaka K; Endo M; Sugiyama H

  Chemistry, an Asian journal, 2019年12月02日, 査読有り

  
• Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide.

  Malinee M; Kumar A; Hidaka T; Horie M; Hasegawa K; Pandian GN; Sugiyama H

  Bioorganic & medicinal chemistry, 2019年12月, 査読有り

  
• G-quadruplexes as versatile scaffolds for catalysis.

  Yum JH; Park S; Sugiyama H

  Organic & biomolecular chemistry, 2019年11月, 査読有り

  この論文にアクセスする：

  
• Oligomerization of a modular ribozyme assembly of which is controlled by a programmable RNA–RNA interface between two structural modules

  Ryusei Tsuruga; Narumi Uehara; Yuki Suzuki; Hiroyuki Furuta; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  Journal of Bioscience and Bioengineering, 2019年10月, 査読有り

  
• Highly sensitive and selective mercury sensor based on mismatched base pairing with dioxT.

  Han JH; Hirashima S; Park S; Sugiyama H

  Chemical communications (Cambridge, England), 2019年08月, 査読有り

  この論文にアクセスする：

  
• Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole-Imidazole Polyamides.

  Hirose Y; Asamitsu S; Bando T; Sugiyama H

  Journal of the American Chemical Society, 2019年08月, 査読有り

  
• Switching Off Cancer-Causing Telomerase Using Small Molecules.

  Asamitsu S; Shioda N; Sugiyama H

  Cell chemical biology, 2019年08月, 査読有り

  
• Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

  Takashi Mino; Noriki Iwai; Masayuki Endo; Kentaro Inoue; Kotaro Akaki; Fabian Hia; Takuya Uehata; Tomoko Emura; Kumi Hidaka; Yutaka Suzuki; Daron M Standley; Mariko Okada-Hatakeyama; Shigeo Ohno; Hiroshi Sugiyama; Akio Yamashita; Osamu Takeuchi

  Nucleic Acids Research, 2019年07月22日, 査読有り

  この論文にアクセスする：

  
• A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell

  Takeshi Tohgasaki; Yasuyuki Shitomi; Yihong Feng; Saisei Honna; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Bioconjugate Chemistry, 2019年07月17日, 査読有り

  
• Direct Observation and Analysis of the Dynamics of the Photoresponsive Transcription Factor GAL4

  Guruprasad Raghavan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  Angewandte Chemie International Edition, 2019年06月03日, 査読有り

  
• Orientation preferences of hairpin pyrrole-imidazole polyamides toward ^mCGG site.

  Sato S; Asamitsu S; Bando T; Sugiyama H

  Bioorganic & medicinal chemistry, 2019年06月, 査読有り

  
• New Size-expanded Fluorescent Thymine Analogue: Synthesis, Characterization, and Application.

  Hiroshima S; Han JH; Tsuno H; Tanigaki Y; Park S; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2019年05月, 査読有り

  
• Programming Rotary Motions with a Hexagonal DNA Nanomachine

  Yangyang Yang; Shiwei Zhang; Shengtao Yao; Rizhao Pan; Kumi Hidaka; Tomoko Emura; Chunhai Fan; Hiroshi Sugiyama; Yufang Xu; Masayuki Endo; Xuhong Qian

  Chemistry – A European Journal, 2019年04月05日, 査読有り

  
• Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface.

  Mandal S; Kawamoto Y; Yue Z; Hashiya K; Cui Y; Bando T; Pandey S; Hoque ME; Hossain MA; Sugiyama H; Mao H

  Nucleic acids research, 2019年03月, 査読有り

  
• Therapeutic gene regulation using pyrrole-imidazole polyamides.

  Yu Z; Pandian GN; Hidaka T; Sugiyama H

  Advanced drug delivery reviews, 2019年02月, 査読有り

  
• Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones.

  Yum JH; Park S; Hiraga R; Okamura I; Notsu S; Sugiyama H

  Organic & biomolecular chemistry, 2019年02月, 査読有り

  
• Direct Observation of the Double-Stranded DNA Formation through Metal Ion-Mediated Base Pairing in the Nanoscale Structure

  Xiwen Xing; Yihong Feng; Zutao Yu; Kumi Hidaka; Fenyong Liu; Akira Ono; Hiroshi Sugiyama; Masayuki Endo

  Chemistry - A European Journal, 2019年01月28日, 査読有り

  
• Direct observation of dynamic movement of DNA molecules in DNA origami imaged using high-speed AFM

  M. Endo; X. Xing; H. Sugiyama

  Methods in Molecular Biology, 2019年, 査読有り, 招待有り

  
• 脂質膜表面におけるDNAオリガミの二次元自己集合化

  鈴木 勇揮; 遠藤 政幸; 杉山 弘

  生物物理, 2019年, 査読有り, 招待有り

  
• Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM

  Masayuki Endo; Xiwen Xing; Hiroshi Sugiyama

  Methods in Molecular Biology, 2019年, 査読有り

  
• Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy.

  Asamitsu S; Obata S; Yu Z; Bando T; Sugiyama H

  Molecules (Basel, Switzerland), 2019年01月, 査読有り

  この論文にアクセスする：

  
• Molecular characteristics of DNA-alkylating PI polyamides targeting RUNX transcription factors.

  Maeda R; Sato S; Ohno T; Kashiwazaki G; Obata S; Hashiya K; Bando T; Sugiyama H

  Journal of the American Chemical Society, 2019年01月, 査読有り

  
• RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

  Yoshihide Mitsuda; Ken Morita; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Moeka Obara; Masahiro Hirata; Tatsuki R. Kataoka; Manabu Muto; Yasufumi Kaneda; Tatsutoshi Nakahata; Pu Paul Liu; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo

  Scientific Reports, 2018年12月01日, 査読有り

  この論文にアクセスする：

  
• Chemical Control System of Epigenetics.

  Vaijayanthi T; Pandian GN; Sugiyama H

  Chemical record (New York, N.Y.), 2018年12月, 査読有り

  
• Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-Quadruplex.

  Jonchhe S; Ghimire C; Cui Y; Sasaki S; McCool M; Park S; Iida K; Nagasawa K; Sugiyama H; Mao H

  Angewandte Chemie (International ed. in English), 2018年11月, 査読有り

  
• Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.

  Hashiya F; Ito S; Sugiyama H

  Bioorganic & medicinal chemistry, 2018年11月, 査読有り

  
• Construction of integrated gene logic-chip

  Takeya Masubuchi; Masayuki Endo; Ryo Iizuka; Ayaka Iguchi; Dong Hyun Yoon; Tetsushi Sekiguchi; Hao Qi; Ryosuke Iinuma; Yuya Miyazono; Shuichi Shoji; Takashi Funatsu; Hiroshi Sugiyama; Yoshie Harada; Takuya Ueda; Hisashi Tadakuma

  Nature Nanotechnology, 2018年10月01日, 査読有り

  
• Decreased water activity in nanoconfinement contributes to the folding of G-quadruplex and i-motif structures

  Sagun Jonchhe; Shankar Pandey; Tomoko Emura; Kumi Hidaka; Mohammad Akter Hossain; Prakash Shrestha; Hiroshi Sugiyama; Masayuki Endo; Hanbin Mao

  Proceedings of the National Academy of Sciences, 2018年09月18日, 査読有り

  
• Novel Approach to the Investigation of Nucleosome Structure Using the Highly Emissive Nucleobase thdG-tC FRET Pair.

  Han JH; Park S; Hashiya F; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2018年09月, 査読有り

  
• Sequence preference and structural heterogeneity of BZ junctions.

  Kim D; Hur J; Han JH; Ha SC; Shin D; Lee S; Park S; Sugiyama H; Kim KK

  Nucleic acids research, 2018年09月, 査読有り

  
• Direct observation of H3-H4 octasome by high-speed AFM.

  Zou T; Hashiya F; Wei Y; Pandian GN; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2018年08月, 査読有り

  
• DNA Origami Nanomachines

  Masayuki Endo; Hiroshi Sugiyama

  Molecules, 2018年07月18日, 査読有り

  
• Colloidal stability of lipid/protein-coated nanomaterials in salt and sucrose solutions.

  NAMASIVAYAM; Ganesh Pandian

  ChemistrySelect, 2018年07月, 査読有り

  
• Environment-Dependent Self-Assembly of DNA Origami Lattices on Phase-Separated Lipid Membranes

  Yusuke Sato; Masayuki Endo; Masamune Morita; Masahiro Takinoue; Hiroshi Sugiyama; Satoshi Murata; Shin-ichiro M. Nomura; Yuki Suzuki

  Advanced Materials Interfaces, 2018年07月, 査読有り

  
• Orthogonal γPNA dimerization domains empower DNA binders with cooperativity and versatility mimicking that of transcription factor pairs.

  Yu Z; Hsieh WC; Asamitsu S; Hashiya K; Bando T; Ly DH; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2018年07月, 査読有り

  
• Ligand design to acquire specificity to intended G-quadruplex structures.

  Asamitsu S; Bando T; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2018年07月, 査読有り

  
• Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones

  Junichi Taniguchi; Yihong Feng; Ganesh N. Pandian; Fumitaka Hashiya; Takuya Hidaka; Kaori Hashiya; Soyoung Park; Toshikazu Bando; Shinji Ito; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2018年06月13日, 査読有り

  この論文にアクセスする：

  
• Complexing DNA Origami Frameworks through Sequential Self-Assembly Based on Directed Docking.

  Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo

  Angewandte Chemie (International ed. in English), 2018年06月11日, 査読有り

  
• TAMRA-polypyrrole for A/T sequence visualization on DNA molecules.

  Lee S; Kawamoto Y; Vaijayanthi T; Park J; Bae J; Kim-Ha J; Sugiyama H; Jo K

  Nucleic acids research, 2018年06月, 査読有り

  
• Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome article

  Norifumi Shioda; Yasushi Yabuki; Kouya Yamaguchi; Misaki Onozato; Yue Li; Kenji Kurosawa; Hideyuki Tanabe; Nobuhiko Okamoto; Takumi Era; Hiroshi Sugiyama; Takahito Wada; Kohji Fukunaga

  Nature Medicine, 2018年06月01日, 査読有り

  この論文にアクセスする：

  
• Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications

  Yusuke Kawamoto; Toshikazu Bando; Hiroshi Sugiyama

  Bioorganic and Medicinal Chemistry, 2018年05月01日, 査読有り

  
• Investigating Nucleosome Accessibility for MNase, Fe^II  Peplomycin, and Duocarmycin B₂ by Using Capillary Electrophoresis.

  Zou T; Kizaki S; Sugiyama H

  Chembiochem : a European journal of chemical biology, 2018年04月04日, 査読有り

  この論文にアクセスする：

  
• Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex

  Sefan Asamitsu; Shunsuke Obata; Anh Tuân Phan; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Chemistry - A European Journal, 2018年03月20日, 査読有り

  
• DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels.

  Tatsuki Kurokawa; Shigeki Kiyonaka; Eiji Nakata; Masayuki Endo; Shohei Koyama; Emiko Mori; Nam Ha Tran; Huyen Dinh; Yuki Suzuki; Kumi Hidaka; Masaaki Kawata; Chikara Sato; Hiroshi Sugiyama; Takashi Morii; Yasuo Mori

  Angewandte Chemie (International ed. in English), 2018年03月01日, 査読有り

  
• RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice.

  Morita K; Tokushige C; Maeda S; Kiyose H; Noura M; Iwai A; Yamada M; Kashiwazaki G; Taniguchi J; Bando T; Hirata M; Kataoka TR; Nakahata T; Adachi S; Sugiyama H; Kamikubo Y

  Blood advances, 2018年03月, 査読有り

  この論文にアクセスする：

  
• Pip-HoGu: An Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs

  Zutao Yu; Chuanxin Guo; Yulei Wei; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2018年02月21日, 査読有り

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• Triggering nucleic acid nanostructure assembly by conditional kissing interactions

  Laurent Azéma; Servane Bonnet-Salomon; Masayuki Endo; Yosuke Takeuchi; Guillaume Durand; Tomoko Emura; Kumi Hidaka; Eric Dausse; Hiroshi Sugiyama; Jean-Jacques Toulmé

  Nucleic Acids Research, 2018年02月16日, 査読有り

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• G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer

  Shunsuke Obata; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Biochemistry, 2018年02月06日, 査読有り

  この論文にアクセスする：

  
• Direct Observation of Dynamic Movement of DNA Molecules in DNA Origami Imaged Using High-Speed AFM

  Masayuki Endo; Hiroshi Sugiyama

  Methods in Molecular Biology, 2018年, 査読有り

  
• Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation

  Yulei Wei; Ganesh N. Pandian; Zutao Yu; Tingting Zou; Yue Li; Jayant Darokar; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  ACS Omega, 2018年, 査読有り

  
• UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258

  Abhijit Saha; Seiichiro Kizaki; Ji Hoon Han; Zutao Yu; Hiroshi Sugiyama

  Bioorganic and Medicinal Chemistry, 2018年01月01日, 査読有り

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• Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer

  Gengo Kashiwazaki; Rina Maeda; Takashi Kawase; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Bioorganic and Medicinal Chemistry, 2018年01月01日, 査読有り

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• DNA配列認識副溝結合物質(MGB)を応用した生体内のゲノム・エピゲノム構造介入 ピロールイミダゾールポリアミドによるクロマチン構造とダイナミクスの機能解析

  井手 聖; 佐々木 飛鳥; 河本 佑介; 板東 俊和; 杉山 弘; 岡田 康志; 前島 一博

  生命科学系学会合同年次大会, 2017年12月, 査読有り

  
• A Combination of Visible-light Photoredox and Metal Catalysis for the Mannich-type Reaction of N-Aryl Glycine Esters

  Izumi Okamura; Soyoung Park; Ji Hoon Han; Shunta Notsu; Hiroshi Sugiyama

  CHEMISTRY LETTERS, 2017年11月, 査読有り

  
• Single-Molecule Observation of the Photoregulated Conformational Dynamics of DNA Origami Nanoscissors

  Elena M. Willner; Yuu Kamada; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Hendrik Dietz; Hiroshi Sugiyama; Masayuki Endo

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017年11月, 査読有り

  
• Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

  Ken Morita; Mina Noura; Chieko Tokushige; Shintaro Maeda; Hiroki Kiyose; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Kenichi Yoshida; Toshifumi Ozaki; Hidemasa Matsuo; Seishi Ogawa; Pu Paul Liu; Tatsutoshi Nakahata; Hiroshi Sugiyama; Souichi Adachi; Yasuhiko Kamikubo

  SCIENTIFIC REPORTS, 2017年11月, 査読有り

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• Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex

  Jumpei Ariyoshi; Yohei Matsuyama; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi

  NUCLEIC ACID THERAPEUTICS, 2017年10月, 査読有り

  
• Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors

  Zutao Yu; Junichi Taniguchi; Yulei Wei; Ganesh N. Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017年09月, 査読有り

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• Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate

  Tomonori Shibata; Yoshihiko Fujita; Hirohisa Ohno; Yuki Suzuki; Karin Hayashi; Kaoru R. Komatsu; Shunsuke Kawasaki; Kumi Hidaka; Shin Yonehara; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito

  NATURE COMMUNICATIONS, 2017年09月, 査読有り

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• A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm

  Junichi Taniguchi; Ganesh N. Pandian; Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Kyeong Kyu Kim; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2017年09月, 査読有り

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• Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction

  Sohei Sakashita; Soyoung Park; Hiroshi Sugiyama

  CHEMISTRY LETTERS, 2017年08月

  
• Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions.

  Morita K; Maeda S; Suzuki K; Kiyose H; Taniguchi J; Liu PP; Sugiyama H; Adachi S; Kamikubo Y

  Blood advances, 2017年08月, 査読有り

  この論文にアクセスする：

  
• WITHDRAWN: Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer.

  Kashiwazaki G; Maeda R; Kawase T; Hashiya K; Bando T; Sugiyama H

  Bioorganic & medicinal chemistry, 2017年07月, 査読有り

  
• Confined space facilitates G-quadruplex formation

  Prakash Shrestha; Sagun Jonchhe; Tomoko Emura; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao

  NATURE NANOTECHNOLOGY, 2017年06月, 査読有り

  
• Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair

  Ji Hoon Han; Seigi Yamamoto; Soyoung Park; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2017年06月, 査読有り

  
• Genetic regulation of the RUNX transcription factor family has antitumor effects

  Ken Morita; Kensho Suzuki; Shintaro Maeda; Akihiko Matsuo; Yoshihide Mitsuda; Chieko Tokushige; Gengo Kashiwazaki; Junichi Taniguchi; Rina Maeda; Mina Noura; Masahiro Hirata; Tatsuki Kataoka; Ayaka Yano; Yoshimi Yamada; Hiroki Kiyose; Mayu Tokumasu; Hidemasa Matsuo; Sunao Tanaka; Yasushi Okuno; Manabu Muto; Kazuhito Naka; Kosei Ito; Toshio Kitamura; Yasufumi Kaneda; Paul P. Liu; Toshikazu Bando; Souichi Adachi; Hiroshi Sugiyama; Yasuhiko Kamikubo

  JOURNAL OF CLINICAL INVESTIGATION, 2017年06月, 査読有り

  
• Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression

  Takuya Hidaka; Ganesh N. Pandian; Junichi Taniguchi; Tomohiro Nobeyama; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017年06月, 査読有り

  
• Programmable formation of catalytic RNA triangles and squares by assembling modular RNA enzymes

  Hiroki Oi; Daisuke Fujita; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Shigeyoshi Matsumura; Yoshiya Ikawa

  JOURNAL OF BIOCHEMISTRY, 2017年05月, 査読有り

  
• Holliday junction resolvases mediate chloroplast nucleoid segregation

  Yusuke Kobayashi; Osami Misumi; Masaki Odahara; Kota Ishibashi; Masafumi Hirono; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama; Hiroshi Iwasaki; Tsuneyoshi Kuroiwa; Toshiharu Shikanai; Yoshiki Nishimura

  SCIENCE, 2017年05月, 査読有り

  
• A Photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement

  Yangyang Yang; Ryu Tashiro; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  CHEMISTRY-A EUROPEAN JOURNAL, 2017年03月, 査読有り

  
• Synthesis, Photophysical Properties, and Enzymatic Incorporation of an Emissive Thymidine Analogue

  Izumi Okamura; Soyoung Park; Ryota Hiraga; Seigi Yamamoto; Hiroshi Sugiyama

  CHEMISTRY LETTERS, 2017年02月, 査読有り

  
• The chemical compound bubblin induces stomatal mispatterning in Arabidopsis by disrupting the intrinsic polarity of stomatal lineage cells

  Yumiko Sakai; Shigeo S. Sugano; Takashi Kawase; Makoto Shirakawa; Yu Imai; Yusuke Kawamoto; Hiroshi Sugiyama; Tsuyoshi Nakagawa; Ikuko Hara-Nishimura; Tomoo Shimada

  DEVELOPMENT, 2017年02月, 査読有り

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• Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads

  Chao-Da Xiao; Takumi Ishizuka; Xiao-Qing Zhu; Yue Li; Hiroshi Sugiyama; Yan Xu

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017年02月, 査読有り

  
• Characterization of the releasing profile of microRNA from RISC using anti-miRNA oligonucleotides

  Jumpei Ariyoshi; Nao Eimori; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi

  Chemistry Letters, 2017年, 査読有り

  
• DNA分子マシン

  遠藤 政幸; 杉山 弘

  日本化学会編『CSJカレントレビュー 分子マシンの展開』, 2017年, 査読有り

  
• DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates

  Chuanxin Guo; Sefan Asamitsu; Gengo Kashiwazaki; Shinsuke Sato; Toshikazu Bando; Hiroshi Sugiyama

  CHEMBIOCHEM, 2017年01月, 査読有り

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• A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes

  Yulei Wei; Ganesh N. Pandian; Tingting Zou; Junichi Taniguchi; Shinsuke Sato; Gengo Kashiwazaki; Thangavel Vaijayanthi; Takuya Hidaka; Toshikazu Bando; Hiroshi Sugiyama

  CHEMISTRYOPEN, 2016年12月, 査読有り

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• RNA-DNA Triplex Formation by Long Noncoding RNAs

  Yue Li; Junetha Syed; Hiroshi Sugiyama

  Cell Chemical Biology, 2016年11月17日, 査読有り

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• Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein

  Seiichiro Kizaki; Tingting Zou; Yue Li; Yong-Woon Han; Yuki Suzuki; Yoshie Harada; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2016年11月, 査読有り

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• Similarities and Differences between RNA and DNA Double-Helical Structures in Circular Dichroism Spectroscopy: A SAC-CI Study

  Tomoo Miyahara; Hiroshi Nakatsuji; Hiroshi Sugiyama

  JOURNAL OF PHYSICAL CHEMISTRY A, 2016年11月, 査読有り

  
• Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole-Imidazole Polyamide Probes

  Yusuke Kawamoto; Asuka Sasaki; Anandhakumar Chandran; Kaori Hashiya; Satoru Ide; Toshikazu Bando; Kazuhiro Maeshima; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016年10月, 査読有り

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• Torsional Constraints of DNA Substrates Impact Cas9 Cleavage

  Michael H. Raz; Kumi Hidaka; Shana J. Sturla; Hiroshi Sugiyama; Masayuki Endo

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016年10月, 査読有り

  
• Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by High-Throughput Sequencing

  Anandhakumar Chandran; Junetha Syed; Yue Li; Shinsuke Sato; Toshikazu Bando; Hiroshi Sugiyama

  CHEMBIOCHEM, 2016年10月, 査読有り

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• Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome

  Jason Lin; Kiriko Hiraoka; Takayoshi Watanabe; Tony Kuo; Yoshinao Shinozaki; Atsushi Takatori; Nobuko Koshikawa; Anandhakumar Chandran; Joe Otsuki; Hiroshi Sugiyama; Paul Horton; Hiroki Nagase

  PLOS ONE, 2016年10月, 査読有り

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• Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing

  Gengo Kashiwazaki; Anandhakumar Chandran; Sefan Asamitsu; Takashi Kawase; Yusuke Kawamoto; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMBIOCHEM, 2016年09月, 査読有り

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• Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids

  Ganesh N. Pandian; Hiroshi Sugiyama

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2016年08月, 査読有り

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• Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay

  Abhijit Saha; Seiichiro Kizaki; Debojyoti De; Masayuki Endo; Kyeong Kyu Kim; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2016年08月, 査読有り

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• Sequence-specific DNA binding by long hairpin pyrrole-imidazole polyamides containing an 8-amino-3,6-dioxaoctanoic acid unit

  Yoshito Sawatani; Gengo Kashiwazaki; Anandhakumar Chandran; Sefan Asamitsu; Chuanxin Guo; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2016年08月, 査読有り

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• Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores

  Prakash Shrestha; Tomoko Emura; Deepak Koirala; Yunxi Cui; Kumi Hidaka; William J. Maximuck; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao

  NUCLEIC ACIDS RESEARCH, 2016年08月, 査読有り

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• Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide

  Sefan Asamitsu; Yue Li; Toshikazu Bando; Hiroshi Sugiyama

  CHEMBIOCHEM, 2016年07月, 査読有り

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• Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes

  Asuka Sasaki; Satoru Ide; Yusuke Kawamoto; Toshikazu Bando; Yukinori Murata; Mari Shimura; Kazuhiko Yamada; Akiyoshi Hirata; Kiyoshi Nokihara; Tatsumi Hirata; Hiroshi Sugiyama; Kazuhiro Maeshima

  SCIENTIFIC REPORTS, 2016年07月, 査読有り

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• A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

  Yousuke Katsuda; Shin-ichi Sato; Lisa Asano; Yoshitaka Morimura; Tomoyuki Furuta; Hiroshi Sugiyama; Masaki Hagihara; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016年07月, 査読有り

  
• Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B-2 to Duplex DNA

  Tingting Zou; Seiichiro Kizaki; Ganesh N. Pandian; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2016年06月, 査読有り

  この論文にアクセスする：

  
• Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on α-Globin Gene Expression.

  Li Y; Syed J; Suzuki Y; Asamitsu S; Shioda N; Wada T; Sugiyama H

  Chembiochem : a European journal of chemical biology, 2016年05月, 査読有り

  この論文にアクセスする：

  
• Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing

  Anandhakumar Chandran; Junetha Syed; Rhys D. Taylor; Gengo Kashiwazaki; Shinsuke Sato; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2016年05月, 査読有り

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• Triple Helix Formation in a Topologically Controlled DNA Nanosystem

  Yutaro Yamagata; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo

  CHEMISTRY-A EUROPEAN JOURNAL, 2016年04月, 査読有り

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• Identification of Sequence Specificity of 5-Methylcytosine Oxidation by Tet1 Protein with High-Throughput Sequencing

  Seiichiro Kizaki; Anandhakumar Chandran; Hiroshi Sugiyama

  CHEMBIOCHEM, 2016年03月, 査読有り

  この論文にアクセスする：

  
• A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function

  Anton Kuzyk; Yangyang Yang; Xiaoyang Duan; Simon Stoll; Alexander O. Govorov; Hiroshi Sugiyama; Masayuki Endo; Na Liu

  NATURE COMMUNICATIONS, 2016年02月, 査読有り

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• Single-molecule observations of RNA-RNA kissing interactions in a DNA nanostructure

  Yosuke Takeuchi; Masayuki Endo; Yuki Suzuki; Kumi Hidaka; Guillaume Durand; Eric Dausse; Jean-Jacques Toulme; Hiroshi Sugiyama

  BIOMATERIALS SCIENCE, 2016年, 査読有り

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• The application of fluorescence-conjugated pyrrole/imidazole polyamides in the characterization of protein-DNA complex formation

  Yong-Woon Han; Hiroshi Sugiyama; Yoshie Harada

  BIOMATERIALS SCIENCE, 2016年, 査読有り

  
• Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion (vol 5, 14979, 2015)

  Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa

  SCIENTIFIC REPORTS, 2016年01月, 査読有り

  
• Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells

  Yu Nishida; Shozo Ohtsuki; Yuki Araie; Yuka Umeki; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016年01月, 査読有り

  
• Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA

  Tomoki Shiomi; Mengmeng Tan; Natsuki Takahashi; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  NANO RESEARCH, 2015年12月, 査読有り

  
• Water revealed as molecular mirror when measuring low concentrations of sugar with near infrared light

  György Bázár; Zoltan Kovacs; Mariko Tanaka; Akane Furukawa; Airi Nagai; Manami Osawa; Yukari Itakura; Hiroshi Sugiyama; Roumiana Tsenkova

  Analytica Chimica Acta, 2015年10月08日, 査読有り

  
• Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion

  Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa

  SCIENTIFIC REPORTS, 2015年10月, 査読有り

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• Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells

  Shozo Ohtsuki; Noriyuki Matsuzaki; Kohta Mohri; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Kenichi Ishiyama; Norimitsu Kadowaki; Yoshinobu Takakura; Makiya Nishikawa

  NUCLEIC ACID THERAPEUTICS, 2015年10月, 査読有り

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• Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression

  Sahishnu Patel; Sy-Tsong Dean Chueng; Perry T. Yin; Kholud Dardir; Zhichao Song; Nicholas Pasquale; Kelvin Kwan; Hiroshi Sugiyama; Ki-Bum Lee

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015年10月, 査読有り

  
• Direct Visualization of Walking Motions of Photocontrolled Nanomachine on the DNA Nanostructure

  Yangyang Yang; Marisa A. Goetzfried; Kumi Hidaka; Mingxu You; Weihong Tan; Hiroshi Sugiyama; Masayuki Endo

  NANO LETTERS, 2015年10月, 査読有り

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• Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates.

  Taylor RD; Chandran A; Kashiwazaki G; Hashiya K; Bando T; Nagase H; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2015年10月, 査読有り

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• Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure

  Masayuki Endo; Xiwen Xing; Xiang Zhou; Tomoko Emura; Kumi Hidaka; Bodin Tuesuwan; Hiroshi Sugiyama

  ACS NANO, 2015年10月, 査読有り

  この論文にアクセスする：

  
• Studying RNAP-promoter interactions using atomic force microscopy

  Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama

  METHODS, 2015年09月, 査読有り

  
• Single-Molecule Visualization of the Activity of a Zn2+-Dependent DNAzyme

  Masayuki Endo; Yosuke Takeuchi; Yuki Suzuki; Tomoko Emura; Kumi Hidaka; Fuan Wang; Itamar Willner; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015年09月, 査読有り

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• Development of DNA Metalloenzymes Using a Rational Design Approach and Application in the Asymmetric Diels-Alder Reaction

  Soyoung Park; Izumi Okamura; Sohei Sakashita; Ji Hye Yum; Chiranjit Acharya; Li Gao; Hiroshi Sugiyama

  ACS CATALYSIS, 2015年08月, 査読有り

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• Linking two DNA duplexes with a rigid linker for DNA nanotechnology

  Ryu Tashiro; Masahiro Iwamoto; Hironobu Morinaga; Tomoko Emura; Kumi Hidaka; Masayuki Endo; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2015年08月, 査読有り

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• Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease

  Atsushi Umemura; Tomoko Oeda; Kenji Yamamoto; Satoshi Tomita; Masayuki Kohsaka; Kwiyoung Park; Hiroshi Sugiyama; Hideyuki Sawada

  PLOS ONE, 2015年08月, 査読有り

  この論文にアクセスする：

  
• Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures

  Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama

  NATURE COMMUNICATIONS, 2015年08月, 査読有り

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• A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts

  Junetha Syed; Anandhakumar Chandran; Ganesh N. Pandian; Junichi Taniguchi; Shinsuke Sato; Kaori Hashiya; Gengo Kashiwazaki; Toshikazu Bando; Hiroshi Sugiyama

  CHEMBIOCHEM, 2015年07月, 査読有り

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• A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network

  Le Han; Ganesh N. Pandian; Anandhakumar Chandran; Shinsuke Sato; Junichi Taniguchi; Gengo Kashiwazaki; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Yufang Xu; Xuhong Qian; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015年07月, 査読有り

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• Inducing Stem Cell Myogenesis Using NanoScript

  Sahishnu Patel; Perry T. Yin; Hiroshi Sugiyama; Ki-Bum Lee

  ACS NANO, 2015年07月, 査読有り

  
• Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics

  Noriko Goto; Gyorgy Bazar; Zoltan Kovacs; Makoto Kunisada; Hiroyuki Morita; Seiichiro Kizaki; Hiroshi Sugiyama; Roumiana Tsenkova; Chikako Nishigori

  SCIENTIFIC REPORTS, 2015年07月, 査読有り

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• DNA NANOTECHNOLOGY Measuring chloride in live cells

  Masayuki Endo; Hiroshi Sugiyama

  NATURE NANOTECHNOLOGY, 2015年07月, 査読有り

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• Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.

  Igarashi J; Fukuda N; Inoue T; Nakai S; Saito K; Fujiwara K; Matsuda H; Ueno T; Matsumoto Y; Watanabe T; Nagase H; Bando T; Sugiyama H; Itoh T; Soma M

  PloS one, 2015年05月, 査読有り

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• Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells

  Kohta Mohri; Eri Kusuki; Shozo Ohtsuki; Natsuki Takahashi; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa

  BIOMACROMOLECULES, 2015年04月, 査読有り

  
• Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells

  Sahishnu Patel; Thanapat Pongkulapa; Perry T. Yin; Ganesh N. Pandian; Christopher Rathnam; Toshikazu Bando; Thangavel Vaijayanthi; Hiroshi Sugiyama; Ki-Bum Lee

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015年04月, 査読有り

  
• Mimicking Membrane-Related Biological Events by DNA Origami Nanotechnology

  Yuki Suzuki; Masayuki Endo; Hiroshi Sugiyama

  ACS NANO, 2015年04月, 査読有り

  
• Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate

  Kiriko Hiraoka; Takahiro Inoue; Rhys Dylan Taylor; Takayoshi Watanabe; Nobuko Koshikawa; Hiroyuki Yoda; Ken-ichi Shinohara; Atsushi Takatori; Hirokazu Sugimoto; Yoshiaki Maru; Tadamichi Denda; Kyoko Fujiwara; Allan Balmain; Toshinori Ozaki; Toshikazu Bando; Hiroshi Sugiyama; Hiroki Nagase

  NATURE COMMUNICATIONS, 2015年04月, 査読有り

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• Rational design of specific binding hairpin Py-Im polyamides targeting human telomere sequences

  Chuanxin Guo; Yusuke Kawamoto; Sefan Asamitsu; Yoshito Sawatani; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2015年02月, 査読有り

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• Synthetic strategies to identify and regulate noncoding RNAs

  Ganesh N. Pandian; Junetha Syed; Hiroshi Sugiyama

  Long Noncoding RNAs Structures and Functions, 2015年01月01日, 査読有り

  
• Development of a visible nanothermometer with a highly emissive 2 '-O-methylated guanosine analogue

  Seigi Yamamoto; Soyoung Park; Hiroshi Sugiyama

  RSC ADVANCES, 2015年, 査読有り

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• Direct Observation of G-Quadruplexes and their Folding Intermediates

  A. Rajendran; Y. Li; M. Endo; H. Sugiyama

  DNA G-quadruplexes as new anticancer targets (R. De Vooght-Johnson Ed.), Future Science, 2015年, 査読有り

  
• Tandem trimer pyrrole-imidazole polyamide probes targeting 18 base pairs in human telomere sequences

  Yusuke Kawamoto; Asuka Sasaki; Kaori Hashiya; Satoru Ide; Toshikazu Bando; Kazuhiro Maeshima; Hiroshi Sugiyama

  CHEMICAL SCIENCE, 2015年, 査読有り

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• Photoreactivity of the linker region of two consecutive G-quadruplexes formed by human telomeric DNA

  Yue Li; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2015年, 査読有り

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• Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2015年, 査読有り

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• A novel detection technique of polyamide binding sites by photo-induced electron transfer in BrU substituted DNA

  Abhijit Saha; Fumitaka Hashiya; Seiichiro Kizaki; Sefan Asamitsu; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2015年, 査読有り

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• Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies

  Chandran Anandhakumar; Seiichiro Kizaki; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  CHEMBIOCHEM, 2015年01月, 査読有り

  この論文にアクセスする：

  
• Folding RNA-Protein Complex into Designed Nanostructures.

  Tomonori Shibata; Yuki Suzuki; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito

  Methods in molecular biology (Clifton, N.J.), 2015年, 査読有り

  
• Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts

  Ganesh N. Pandian; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Kazuhiro Takashima; Junetha Syed; Le Han; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  ACS CHEMICAL BIOLOGY, 2014年12月, 査読有り

  
• Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of β-alanine.

  Anandhakumar C; Li Y; Kizaki S; Pandian GN; Hashiya K; Bando T; Sugiyama H

  Chembiochem : a European journal of chemical biology, 2014年12月, 査読有り

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• Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA

  Fumitaka Hashiya; Abhijit Saha; Seiichiro Kizaki; Yue Li; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2014年12月, 査読有り

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• Preparation of Chemically Modified RNA Origami Nanostructures

  Masayuki Endo; Yosuke Takeuchi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  Chemistry - A European Journal, 2014年11月01日, 査読有り

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• Development of DNA-Based Hybrid Catalysts through Direct Ligand Incorporation: Toward Understanding of DNA-Based Asymmetric Catalysis

  Soyoung Park; Linjie Zheng; Shunsuke Kumakiri; Sohei Sakashita; Haruka Otomo; Keiichi Ikehata; Hiroshi Sugiyama

  ACS CATALYSIS, 2014年11月, 査読有り

  
• Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials

  Tomohiro Takenaka; Masayuki Endo; Yuki Suzuki; Yangyang Yang; Tomoko Emura; Kumi Hidaka; Takayuki Kato; Tomoko Miyata; Keiichi Namba; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2014年11月, 査読有り

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• Direct quantification of loop interaction and π-π stacking for G-quadruplex stability at the submolecular level.

  Ghimire C; Park S; Iida K; Yangyuoru P; Otomo H; Yu Z; Nagasawa K; Sugiyama H; Mao H

  Journal of the American Chemical Society, 2014年11月, 査読有り

  
• Preparation of Chemically Modified RNA Origami Nanostructures

  Masayuki Endo; Yosuke Takeuchi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2014年11月, 査読有り

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• Chemical modification of a synthetic small molecule boosts its biological efficacy against pluripotency genes in mouse fibroblasts.

  Saha A; Pandian GN; Sato S; Taniguchi J; Kawamoto Y; Hashiya K; Bando T; Sugiyama H

  ChemMedChem, 2014年10月, 査読有り

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• Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMMEDCHEM, 2014年10月, 査読有り

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• Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide

  Junetha Syed; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Anandhakumar Chandran; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMISTRY & BIOLOGY, 2014年10月, 査読有り

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• Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates

  Rhys Dylan Taylor; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMISTRY-AN ASIAN JOURNAL, 2014年09月, 査読有り

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• Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats

  Sefan Asamitsu; Yusuke Kawamoto; Fumitaka Hashiya; Kaori Hashiya; Makoto Yamamoto; Seiichiro Kizaki; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2014年09月, 査読有り

  この論文にアクセスする：

  
• NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation

  Sahishnu Patel; Dongju Jung; Perry T. Yin; Peter Carlton; Makoto Yamamoto; Toshikazu Bando; Hiroshi Sugiyama; Ki-Bum Lee

  ACS NANO, 2014年09月, 査読有り

  
• A lock-and-key mechanism for the controllable fabrication of DNA origami structures

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Naohiko Shimada; Atsushi Maruyama; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2014年08月, 査読有り

  
• Structural Evaluation of Tandem Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres

  Akiyoshi Hirata; Kiyoshi Nokihara; Yusuke Kawamoto; Toshikazu Bando; Asuka Sasaki; Satoru Ide; Kazuhiro Maeshima; Takeshi Kasama; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014年08月, 査読有り

  
• Engineering RNA-Protein Complexes with Different Shapes for Imaging and Therapeutic Applications

  Eriko Osada; Yuki Suzuki; Kumi Hidaka; Hirohisa Ohno; Hiroshi Sugiyama; Masayuki Endo; Hirohide Saito

  ACS NANO, 2014年08月, 査読有り

  
• Helical DNA Origami Tubular Structures with Various Sizes and Arrangements

  Masayuki Endo; Seigi Yamamoto; Tomoko Emura; Kumi Hidaka; Nobuhiro Morone; John E. Heuser; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014年07月, 査読有り

  
• Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures

  Deepak Koirala; Prakash Shrestha; Tomoko Emura; Kumi Hidaka; Shankar Mandal; Masayuki Endo; Hiroshi Sugiyama; Hanbin Mao

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014年07月, 査読有り

  
• Single-Molecule Imaging of Dynamic Motions of Biomolecules in DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy

  Masayuki Endo; Hiroshi Sugiyama

  ACCOUNTS OF CHEMICAL RESEARCH, 2014年06月, 査読有り

  
• Single Molecule Visualization and Characterization of Sox2-Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame

  Seigi Yamamoto; Debojyoti De; Kumi Hidaka; Kyeong Kyu Kim; Masayuki Endo; Hiroshi Sugiyama

  NANO LETTERS, 2014年05月, 査読有り

  
• The origin of enantioselectivity for intramolecular Friedel-Crafts reaction catalyzed by supramolecular Cu/DNA catalyst complex

  Galina P. Petrova; Zhuofeng Ke; Soyoung Park; Hiroshi Sugiyama; Keiji Morokuma

  CHEMICAL PHYSICS LETTERS, 2014年04月, 査読有り

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• Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014年04月, 査読有り

  
• Specific Alkylation of Human Telomere Repeat Sequences by a Tandem-Hairpin Motif of Pyrrole-Imidazole Polyamides with Indole-seco-CBI

  Makoto Yamamoto; Toshikazu Bando; Yusuke Kawamoto; Rhys Dylan Taylor; Kaori Hashiya; Hiroshi Sugiyama

  BIOCONJUGATE CHEMISTRY, 2014年03月, 査読有り

  
• Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control.

  Pandian GN; Taniguchi J; Sugiyama H

  Clinical and translational medicine, 2014年03月, 査読有り

  
• Dynamic Assembly/Disassembly Processes of Photoresponsive DNA Origami Nanostructures Directly Visualized on a Lipid Membrane Surface

  Yuki Suzuki; Masayuki Endo; Yangyang Yang; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014年02月, 査読有り

  
• Construction and characterization of Cy3-or Cy5-conjugated hairpin pyrrole-imidazole polyamides binding to DNA in the nucleosome

  Yong-Woon Han; Yasuo Tsunaka; Hiroaki Yokota; Tomoko Matsumoto; Gengo Kashiwazaki; Hironobu Morinaga; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama; Yoshie Harada

  BIOMATERIALS SCIENCE, 2014年, 査読有り

  
• Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

  Ganesh N. Pandian; Junichi Taniguchi; Syed Junetha; Shinsuke Sato; Le Han; Abhijit Saha; Chandran AnandhaKumar; Toshikazu Bando; Hiroki Nagase; Thangavel Vaijayanthi; Rhys D. Taylor; Hiroshi Sugiyama

  SCIENTIFIC REPORTS, 2014年01月, 査読有り

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• Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transition

  Soyoung Park; Haruka Otomo; Linjie Zheng; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2014年, 査読有り

  
• Sequence-Specific DNA Recognition by Cyclic Pyrrole-Imidazole Cysteine-Derived Polyamide Dimers

  Makoto Yamamoto; Toshikazu Bando; Hironobu Morinaga; Yusuke Kawamoto; Kaori Hashiya; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2014年01月, 査読有り

  
• G-quadruplex-binding ligand-induced DNA synapsis inside a DNA origami frame

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Hiroshi Sugiyama

  RSC ADVANCES, 2014年, 査読有り

  
• DNA Origami Based Visualization System for Studying Site-Specific Recombination Events

  Yuki Suzuki; Masayuki Endo; Yousuke Katsuda; Keiyu Ou; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014年01月, 査読有り

  
• State-of-the-Art High-Speed Atomic Force Microscopy for Investigation of Single-Molecular Dynamics of Proteins

  Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama

  CHEMICAL REVIEWS, 2014年01月, 査読有り

  
• CGmCGCG is a versatile substrate with which to evaluate Tet protein activity

  Seiichiro Kizaki; Hiroshi Sugiyama

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2014年01月, 査読有り

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• 1P316 Rational design of orthogonal gene transcription nano device on DNA origami(28. Bioengineering,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya

  生物物理, 2014年

  
• Amplification of fluorescent DNA through enzymatic incorporation of a highly emissive deoxyguanosine analogue

  Haruka Otomo; Soyoung Park; Seigi Yamamotoa; Hiroshi Sugiyama

  RSC ADVANCES, 2014年, 査読有り

  この論文にアクセスする：

  
• Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules

  Ganesh N. Pandian; Rhys D. Taylor; Syed Junetha; Abhijit Saha; Chandran Anandhakumar; Thangavel Vaijayanthi; Hiroshi Sugiyama

  BIOMATERIALS SCIENCE, 2014年, 査読有り

  この論文にアクセスする：

  
• Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and challenges

  Ganesh N. Pandian; Hiroshi Sugiyama

  Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, 2014年01月01日, 査読有り

  
• DNA オリガミ構造体を利用した１分子イメージングシステムの開発

  遠藤 政幸; 杉山 弘

  新材料・新素材シリーズ『超分子材料の設計と応用展開』、シーエムシー出版, 2014年, 査読有り

  
• DNA ナノ構造体を利用したDNA 構造変化の１分子イメージング

  遠藤 政幸; 杉山 弘

  DOJIN BIOSCIENCE SERIES『１分子生物学』、化学同人, 2014年, 査読有り

  
• AFM analysis of changes in nucleosome wrapping induced by DNA epigenetic modification

  Seiichiro Kizaki; Yuki Suzuki; Tomohiro Takenaka; Masayuki Endo; Hiroshi Sugiyama

  BIOMATERIALS SCIENCE, 2014年, 査読有り

  この論文にアクセスする：

  
• Controlling electron rebound within four-base π-stacks in Z-DNA by changing the sugar moiety from deoxy- to ribonucleotide.

  Sannohe Y; Kizaki S; Kanesato S; Fujiwara A; Li Y; Morinaga H; Tashiro R; Sugiyama H

  Chemistry (Weinheim an der Bergstrasse, Germany), 2014年01月, 査読有り

  
• Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole-Imidazole Polyamide seco-CBI Conjugates

  Rhys Dylan Taylor; Sefan Asamitsu; Tomohiro Takenaka; Makoto Yamamoto; Kaori Hashiya; Yusuke Kawamoto; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2014年01月, 査読有り

  
• Direct observation of the dual-switching behaviors corresponding to the state transition in a DNA nanoframe

  Yangyang Yang; Masayuki Endo; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2014年, 査読有り

  
• Direct analysis of Holliday junction resolving enzyme in a DNA origami nanostructure

  Yuki Suzuki; Masayuki Endo; Cristina Canas; Silvia Ayora; Juan C. Alonso; Hiroshi Sugiyama; Kunio Takeyasu

  NUCLEIC ACIDS RESEARCH, 2014年, 査読有り

  この論文にアクセスする：

  
• Investigation of B-Z transitions with DNA oligonucleotides containing 8-methylguanine

  Frederic Y.-H. Chen; Soyoung Park; Haruka Otomo; Sohei Sakashita; Hiroshi Sugiyama

  Artificial DNA: PNA and XNA, 2014年, 査読有り

  この論文にアクセスする：

  
• Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA

  Wataru Kameshima; Takumi Ishizuka; Masafumi Minoshima; Makoto Yamamoto; Hiroshi Sugiyama; Yan Xu; Makoto Komiyama

  Angewandte Chemie - International Edition, 2013年12月16日, 査読有り

  
• HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Jean-Louis Mergny; Robert J. Gorelick; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013年12月, 査読有り

  
• Regulation of B-Z Conformational Transition and Complex Formation with a Z-Form Binding Protein by Introduction of Constraint to Double-Stranded DNA by using a DNA Nanoscaffold

  Masayuki Endo; Masahiro Inoue; Yuki Suzuki; Chigusa Masui; Hironobu Morinaga; Kumi Hidaka; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2013年12月, 査読有り

  
• A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell

  Le Han; Ganesh N. Pandian; Syed Junetha; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013年12月, 査読有り

  
• Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources

  Yan-Ling Wu; Ganesh N. Pandian; Yan-Ping Ding; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama

  CHEMISTRY & BIOLOGY, 2013年11月, 査読有り

  
• Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres

  Yusuke Kawamoto; Toshikazu Bando; Fukumi Kamada; Yue Li; Kaori Hashiya; Kazuhiro Maeshima; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013年11月, 査読有り

  
• Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Phong Lan Thao Tran; Jean-Louis Mergny; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2013年10月, 査読有り

  この論文にアクセスする：

  
• Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

  Shigeo Masuda; Jun Wu; Tomoaki Hishida; Ganesh N. Pandian; Hiroshi Sugiyama; Juan Carlos Izpisua Belmonte

  JOURNAL OF MOLECULAR CELL BIOLOGY, 2013年10月, 査読有り

  
• Solid-supported DNA for asymmetric synthesis: A stepping-stone toward practical applications

  Soyoung Park; Keiichi Ikehata; Hiroshi Sugiyama

  Biomaterials Science, 2013年10月, 査読有り

  
• Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5'-GCGC-3'.

  Han YW; Kashiwazaki G; Morinaga H; Matsumoto T; Hashiya K; Bando T; Harada Y; Sugiyama H

  Bioorganic & medicinal chemistry, 2013年09月01日, 査読有り

  この論文にアクセスする：

  
• Guided Assembly of Tetramolecular G-Quadruplexes

  Liliya A. Yatsunyk; Olivier Pietrement; Delphine Albrecht; Phong Lan Thao Tran; Daniel Renciuk; Hiroshi Sugiyama; Jean-Michel Arbona; Jean-Pierre Aime; Jean-Louis Mergny

  ACS NANO, 2013年07月, 査読有り

  
• RNA binding properties of novel gene silencing pyrrole-imidazole polyamides

  Akifumi Iguchi; Noboru Fukuda; Teruyuki Takahashi; Takayoshi Watanabe; Hiroyuki Matsuda; Hiroki Nagase; Toshikazu Bando; Hiroshi Sugiyama; Kazufumi Shimizu

  Biological and Pharmaceutical Bulletin, 2013年07月, 査読有り

  
• Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2013年07月, 査読有り

  
• Hydrochlorothiazide Enhances UVA-Induced DNA Damage

  Makoto Kunisada; Taro Masaki; Ryusuke Ono; Hironobu Morinaga; Eiji Nakano; Flandiana Yogianti; Kunihiro Okunishi; Hiroshi Sugiyama; Chikako Nishigori

  PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2013年05月, 査読有り

  
• Sequence-specific electron injection into DNA from an intermolecular electron donor

  Hironobu Morinaga; Tomohiro Takenaka; Fumitaka Hashiya; Seiichiro Kizaki; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Nucleic Acids Research, 2013年04月, 査読有り

  この論文にアクセスする：

  
• Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences

  Deepak Koirala; Chiran Ghimire; Christopher Bohrer; Yuta Sannohe; Hiroshi Sugiyama; Hanbin Mao

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013年02月, 査読有り

  
• Design of a new fluorescent probe: pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn.

  Vaijayanthi T; Bando T; Hashiya K; Pandian GN; Sugiyama H

  Bioorganic & medicinal chemistry, 2013年02月, 査読有り

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• Direct and real-time observation of rotary movement of a DNA nanomechanical device

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2013年01月23日, 査読有り

  
• Photoreactivities of 5-Bromouracil-containing RNAs

  Hironobu Morinaga; Seiichiro Kizaki; Tomohiro Takenaka; Shuhei Kanesato; Yuta Sannohe; Ryu Tashiro; Hiroshi Sugiyama

  Bioorganic and Medicinal Chemistry, 2013年01月15日, 査読有り

  この論文にアクセスする：

  
• DNA nanomachines that move on the DNA origami structures

  M. Endo; H. Sugiyama

  Kobunshi, 2013年, 査読有り

  
• DNA origami technology for biomaterials applications

  Masayuki Endo; Yangyang Yang; Hiroshi Sugiyama

  BIOMATERIALS SCIENCE, 2013年, 査読有り

  
• RNA-templated DNA origami structures

  Masayuki Endo; Seigi Yamamoto; Koichi Tatsumi; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2013年, 査読有り

  
• Helical Structure and Circular Dichroism Spectra of DNA: A Theoretical Study

  Tomoo Miyahara; Hiroshi Nakatsuji; Hiroshi Sugiyama

  JOURNAL OF PHYSICAL CHEMISTRY A, 2013年01月, 査読有り

  
• Control of the two-dimensional crystallization of DNA origami with various loop arrangements

  Arivazhagan Rajendran; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2013年, 査読有り

  
• The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases

  Jing Liang; Yan-Ling Wu; Bing-Jia Chen; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama

  INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2013年, 査読有り

  
• 3P306 DNAナノ構造体を用いたDNA-RNAポリメラーゼ・ハイブリッドナノマシンの構築と活性評価(28.バイオエンジニアリング,ポスター,日本生物物理学会年会第51回(2013年度))

  Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya

  生物物理, 2013年

  
• GSM1289291: HDF_SAHA-PIP9_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• E-GEOD-53317.raw.1.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.processed.1.zip

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.idf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• A-GEOD-13497.adf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• ChemInform Abstract: Deciphering DNA-Based Asymmetric Catalysis Through Intramolecular Friedel-Crafts Alkylations.

  Park Soyoung; Ikehata Keiichi; Watabe Ryo; Hidaka Yuta; Rajendran Arivazhagan; Sugiyama Hiroshi

  ChemInform, 2013年, 査読有り

  
• DNAオリガミ構造体と高速原子間力顕微鏡を用いた１分子観察系の構築

  遠藤 政幸; 杉山 弘

  生物物理, 2013年, 査読有り

  
• G-quadruplex nanostructures probed at the single molecular level by force-based methods

  S. Dhakal; H. Mao; A. Rajendran; M. Endo; H. Sugiyama

  Guanine quartets: Structure and application, Royal Society of Chemistry, 2013年, 査読有り

  
• Strategies to modulate heritable epigenetic defects in cellular machinery: Lessons from nature

  Ganesh N. Pandian; Hiroshi Sugiyama

  Pharmaceuticals, 2012年12月27日, 査読有り

  
• Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants

  Yong-Woon Han; Tomoko Matsumoto; Hiroaki Yokota; Gengo Kashiwazaki; Hironobu Morinaga; Kaori Hashiya; Toshikazu Bando; Yoshie Harada; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2012年12月, 査読有り

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• Photo-Controllable DNA Origami Nanostructures Assembling into Predesigned Multiorientational Patterns

  Yangyang Yang; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012年12月, 査読有り

  
• DNA as a Chiral Scaffold for Asymmetric Synthesis

  Soyoung Park; Hiroshi Sugiyama

  MOLECULES, 2012年11月, 査読有り

  この論文にアクセスする：

  
• Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes

  Thangavel Vaijayanthi; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  CHEMBIOCHEM, 2012年10月, 査読有り

  
• Synthesis of Pyrrole-Imidazole Polyamide seco-1-Chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole Conjugates with a Vinyl Linker Recognizing a 7 bp DNA Sequence

  Toshiki Takagaki; Toshikazu Bando; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012年08月, 査読有り

  
• A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts

  Ganesh N. Pandian; Yusuke Nakano; Shinsuke Sato; Hironobu Morinaga; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  SCIENTIFIC REPORTS, 2012年07月, 査読有り

  この論文にアクセスする：

  
• Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

  Kohta Mohri; Makiya Nishikawa; Natsuki Takahashi; Tomoki Shiomi; Nao Matsuoka; Kohei Ogawa; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura

  ACS NANO, 2012年07月, 査読有り

  
• Recognition by Nonaromatic and Stereochemical Subunit-Containing Polyamides of the Four Watson-Crick Base Pairs in the DNA Minor Groove

  Hong-Fei Zhang; Yan-Ling Wu; Shi-Kun Jiang; Pu Wang; Hiroshi Sugiyama; Xing-Lai Chen; Wen Zhang; Yan-Juan Ji; Chuan-Xin Guo

  CHEMBIOCHEM, 2012年06月, 査読有り

  
• Programmable genetic switches to control transcriptional machinery of pluripotency

  Ganesh N. Pandian; Hiroshi Sugiyama

  BIOTECHNOLOGY JOURNAL, 2012年06月, 査読有り

  
• Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes

  Ganesh N. Pandian; Akimichi Ohtsuki; Toshikazu Bando; Shinsuke Sato; Kaori Hashiya; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2012年04月, 査読有り

  この論文にアクセスする：

  
• Sequence-Selective Single-Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold

  Tomofumi Yoshidome; Masayuki Endo; Gengo Kashiwazaki; Kumi Hidaka; Toshikazu Bando; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012年03月, 査読有り

  
• Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole-N-Methylimidazole Polyamide Conjugates

  Gengo Kashiwazaki; Toshikazu Bando; Tomofumi Yoshidome; Seiji Masui; Toshiki Takagaki; Kaori Hashiya; Ganesh N. Pandian; Junichi Yasuoka; Kazunari Akiyoshi; Hiroshi Sugiyama

  JOURNAL OF MEDICINAL CHEMISTRY, 2012年03月, 査読有り

  
• A DNA-based molecular motor that can navigate a network of tracks

  Shelley F. J. Wickham; Jonathan Bath; Yousuke Katsuda; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Andrew J. Turberfield

  NATURE NANOTECHNOLOGY, 2012年03月, 査読有り

  この論文にアクセスする：

  
• Single strand DNA catenane synthesis using the formation of G-quadruplex structure

  Yuta Sannohe; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2012年03月, 査読有り

  この論文にアクセスする：

  
• Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure

  Masayuki Endo; Ryoji Miyazaki; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012年02月, 査読有り

  
• Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure

  Masayuki Endo; Koichi Tatsumi; Kosuke Terushima; Yousuke Katsuda; Kumi Hidaka; Yoshie Harada; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012年, 査読有り

  
• Zinc-Finger Proteins for Site-Specific Protein Positioning on DNA-Origami Structures

  Eiji Nakata; Fong Fong Liew; Chisana Uwatoko; Shigeki Kiyonaka; Yasuo Mori; Yousuke Katsuda; Masayuki Endo; Hiroshi Sugiyama; Takashi Morii

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012年, 査読有り

  
• Immunotherapies: The Blockade of Inhibitory Signals

  Yan-Ling Wu; Jing Liang; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama

  INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2012年, 査読有り

  
• Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure

  Masayuki Endo; Yangyang Yang; Yuki Suzuki; Kumi Hidaka; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012年, 査読有り

  
• Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations

  Soyoung Park; Keiichi Ikehata; Ryo Watabe; Yuta Hidaka; Arivazhagan Rajendran; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2012年, 査読有り

  この論文にアクセスする：

  
• SWI/SNF-mediated chromatin remodeling induces Z-DNA formation on a nucleosome

  Niveen Mulholland; Yan Xu; Hiroshi Sugiyama; Keji Zhao

  CELL AND BIOSCIENCE, 2012年01月, 査読有り

  
• Dna origami: Synthesis and self-assembly

  Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama

  Current Protocols in Nucleic Acid Chemistry, 2012年, 査読有り

  
• Structural and functional analysis of proteins by high-speed atomic force microscopy

  Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama

  Advances in Protein Chemistry and Structural Biology, 2012年, 査読有り

  
• Intramolecular folding in three tandem guanine repeats of human telomeric DNA

  Deepak Koirala; Tomoko Mashimo; Yuta Sannohe; Zhongbo Yu; Hanbin Mao; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2012年, 査読有り

  
• Single-Molecule Analysis Using DNA Origami

  Arivazhagan Rajendran; Masayuki Endo; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012年, 査読有り

  
• Discrimination between T/A and A/T base pairs of pyrrole-imidazole polyamides substituted with chiral β-hydroxy-γ-aminobutyric acid/β-alanine pairs.

  Zhang W; Jiang SK; Wu YL; Guo CX; Zhang HF; Sugiyama H; Chen XL

  Chembiochem : a European journal of chemical biology, 2012年01月, 査読有り

  
• 3PT111 DNAナノ構造を用いたDNA-RNAポリメラーゼ・ハイプリッドナノマシンの構築と機能評価(日本生物物理学会第50回年会(2012年度))

  Masubuchi Takeya; Tadakuma Hisashi; Endo Masayuki; Sugiyama Hiroshi; Harada Yoshie; Ueda Takuya

  生物物理, 2012年

  
• ChemInform Abstract: Single-Molecule Analysis Using DNA Origami

  Rajendran Arivazhagan; Endo Masayuki; Sugiyama Hiroshi

  ChemInform, 2012年, 査読有り

  
• DNAオリガミによる１分子観察系の構築

  遠藤 政幸; 杉山 弘

  『疾患克服を目指したケミカルバイオロジー』実験医学2012年増刊号, 2012年, 査読有り

  
• DNAオリガミ構造体と１分子観察への応用

  遠藤 政幸; 杉山 弘

  化学工業, 2012年, 査読有り

  
• Zinc finger proteins as adaptor for locating proteins at specific addresses of DNA origami

  E. Nakata; L. Fong; C. Uwatoko; S. Kiyonaka; Y. Mori; Y. Katsuda; M. Endo; H. Sugiyama; T. Morii

  Angew. Chem. Int. Ed, 2012年, 査読有り

  
• Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts

  Ganesh N. Pandian; Ken-ichi Shinohara; Akimichi Ohtsuki; Yusuke Nakano; Minoshima Masafumi; Toshikazu Bando; Hiroki Nagase; Yasuhiro Yamada; Akira Watanabe; Naohiro Terada; Shinsuke Sato; Hironobu Morinaga; Hiroshi Sugiyama

  CHEMBIOCHEM, 2011年12月, 査読有り

  
• DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization

  Ai Yasuda; Kohji Noguchi; Masafumi Minoshima; Gengo Kashiwazaki; Teru Kanda; Kazuhiro Katayama; Junko Mitsuhashi; Toshikazu Bando; Hiroshi Sugiyama; Yoshikazu Sugimoto

  CANCER SCIENCE, 2011年12月, 査読有り

  
• DNA Origami-based Construction of Meso-scale Multi-dimensional Architects and Expression of the Functionality in the Designed DNA Nanospace

  Masayuki Endo; Hiroshi Sugiyama

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2011年12月, 査読有り

  
• Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition in the DNA Minor Groove

  Hironobu Morinaga; Toshikazu Bando; Toshiki Takagaki; Makoto Yamamoto; Kaori Hashiya; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011年11月, 査読有り

  
• Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation

  Toshiki Takagaki; Toshikazu Bando; Masaaki Kitano; Kaori Hashiya; Gengo Kashiwazaki; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2011年10月, 査読有り

  
• A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

  Deepak Koirala; Soma Dhakal; Beth Ashbridge; Yuta Sannohe; Raphael Rodriguez; Hiroshi Sugiyama; Shankar Balasubramanian; Hanbin Mao

  NATURE CHEMISTRY, 2011年10月, 査読有り

  
• SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome

  N. Mulholland; Y. Xu; H. Sugiyama; K. Zhao

  J. Am. Chem. Soc., 2011年10月, 査読有り

  
• Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly

  Arivazhagan Rajendran; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011年09月, 査読有り

  
• Direct observation of stepwise movement of a synthetic molecular transporter

  Shelley F. J. Wickham; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Jonathan Bath; Hiroshi Sugiyama; Andrew J. Turberfield

  NATURE NANOTECHNOLOGY, 2011年03月, 査読有り

  この論文にアクセスする：

  
• Photocontrollable Sequence-Specific DNA Alkylation by a Pyrrole-Imidazole Polyamide seco-CBI Conjugate

  Soyoung Park; Toshikazu Bando; Ken-ichi Shinohara; Shigeki Nishijima; Hiroshi Sugiyama

  BIOCONJUGATE CHEMISTRY, 2011年02月, 査読有り

  
• Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces

  Arivazhagan Rajendran; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  ACS NANO, 2011年01月, 査読有り

  
• Lightweight Actuator Structure With SMA Honeycomb Core and CFRP Skins

  Yoji Okabe; Hiroshi Sugiyama; Toru Inayoshi

  JOURNAL OF MECHANICAL DESIGN, 2011年01月, 査読有り

  
• Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter.

  Matsuda H; Fukuda N; Ueno T; Katakawa M; Wang X; Watanabe T; Matsui S; Aoyama T; Saito K; Bando T; Matsumoto Y; Nagase H; Matsumoto K; Sugiyama H

  Kidney international, 2011年01月, 査読有り

  
• Recent progress in DNA origami unit 12.8 technology

  Masayuki Endo; Hiroshi Sugiyama

  Current Protocols in Nucleic Acid Chemistry, 2011年, 査読有り

  
• Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold

  Masayuki Endo; Yangyang Yang; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2011年, 査読有り

  
• Direct AFM observation of an opening event of a DNA cuboid constructed via a prism structure

  Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2011年, 査読有り

  
• Two-dimensional DNA origami assemblies using a four-way connector

  Masayuki Endo; Tsutomu Sugita; Arivazhagan Rajendran; Yousuke Katsuda; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama

  CHEMICAL COMMUNICATIONS, 2011年, 査読有り

  
• DNAナノ空間での生体分子のコントロールと直接的な観察

  遠藤 政幸; 杉山 弘

  パリティ, 2011年, 査読有り

  
• Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure

  Yuta Sannohe; Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年11月, 査読有り

  
• Folding Pathways of Human Telomeric Type-1 and Type-2 G-Quadruplex Structures

  Tomoko Mashimo; Hirotaka Yagi; Yuta Sannohe; Arivazhagan Rajendran; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年10月, 査読有り

  
• The Distance Between Donor and Acceptor Affects the Proportion of C1 ' and C2 ' Oxidation Products of DNA in a U-Br-Containing Excess Electron Transfer System

  Ryu Tashiro; Akimichi Ohtsuki; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年10月, 査読有り

  
• Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates

  Gengo Kashiwazaki; Toshikazu Bando; Ken-ichi Shinohara; Masafumi Minoshima; Hana Kumamoto; Shigeki Nishijima; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2010年04月, 査読有り

  
• A Chiral Wedge Molecule Inhibits Telomerase Activity

  Ken-ichi Shinohara; Yuta Sannohe; Shuji Kaieda; Ken-ichi Tanaka; Hideji Osuga; Hidetoshi Tahara; Yan Xu; Takashi Kawase; Toshikazu Bando; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年03月, 査読有り

  
• Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition

  Ken-Ichi Shinohara; Toshikazu Bando; Hiroshi Sugiyama

  ANTI-CANCER DRUGS, 2010年03月, 査読有り

  
• Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide

  Xiaofei Wang; Hiroki Nagase; Takayoshi Watanabe; Hiroyuki Nobusue; Tsukasa Suzuki; Yukihiro Asami; Yui Shinojima; Hiroyuki Kawashima; Keiko Takagi; Rajeev Mishra; Jun Igarashi; Makoto Kimura; Tadatoshi Takayama; Noboru Fukuda; Hiroshi Sugiyama

  CANCER SCIENCE, 2010年03月, 査読有り

  
• Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure

  Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年02月, 査読有り

  
• Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI

  Masafumi Minoshima; Toshikazu Bando; Ken-ichi Shinohara; Gengo Kashiwazaki; Shigeki Nishijima; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2010年02月, 査読有り

  この論文にアクセスする：

  
• Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content

  Shigeki Nishijima; Ken-ichi Shinohara; Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2010年01月, 査読有り

  
• Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes

  Masafumi Minoshima; James C. Chou; Sophie Lefebvre; Toshikazu Bando; Ken-ichi Shinohara; Joel M. Gottesfeld; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2010年01月, 査読有り

  
• RNA ポリメラーゼのDNA ナノ構造上 での１分子観測

  照島功祐; 遠藤政幸; 勝田陽介; 日高久美; 杉山弘

  日本化学会第90 春季年会, 大阪,2010年3 月26 日-3 月 29 日, 2010年, 査読有り

  
• DNA-Based Hybrid Catalysts for Asymmetric Organic Synthesis

  Soyoung Park; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010年, 査読有り

  
• Overview of formation of G-quadruplex structures

  Yuta Sannohe; Hiroshi Sugiyama

  Current Protocols in Nucleic Acid Chemistry, 2010年, 査読有り

  
• Error-prone translesion DNA synthesis by Escherichia coli DNA polymerase IV (DinB) on templates containing 1,2-dihydro-2-oxoadenine

  Masaki Hori; Shin-Ichiro Yonekura; Takehiko Nohmi; Petr Gruz; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama

  Journal of Nucleic Acids, 2010年, 査読有り

  
• A Versatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair

  Masayuki Endo; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010年, 査読有り

  
• Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

  Hiroshi Tanaka; Yoshikazu Tanaka; Masafumi Minoshima; Sho Yamaguchi; Shinichiro Fuse; Takayuki Doi; Susumu Kawauchi; Hiroshi Sugiyama; Takashi Takahashi

  CHEMICAL COMMUNICATIONS, 2010年, 査読有り

  
• Programmed-Assembly System Using DNA Jigsaw Pieces

  Masayuki Endo; Tsutomu Sugita; Yousuke Katsuda; Kumi Hidaka; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2010年, 査読有り

  
• Synthesis and properties of PI polyamide-SAHA conjugate

  Akimichi Ohtsuki; Makoto T. Kimura; Masafumi Minoshima; Tsukasa Suzuki; Maki Ikeda; Toshikazu Bando; Hiroki Nagase; Ken-ichi Shinohara; Hiroshi Sugiyama

  TETRAHEDRON LETTERS, 2009年12月, 査読有り

  この論文にアクセスする：

  
• Photochemistry of 5-Bromouracil- or 5-Iodouracil-containing DNA: Probe for DNA Structure and Charge Transfer Along DNA

  Ryu Tashiro; Hiroshi Sugiyama

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2009年12月, 査読有り

  
• Eukaryotic DNA polymerases alpha, beta and epsilon incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone.

  Katsuhito Kino; Kaoru Sugasawa; Takeshi Mizuno; Toshikazu Bando; Hiroshi Sugiyama; Masaki Akita; Hiroshi Miyazawa; Fumio Hanaoka

  Chembiochem : a European journal of chemical biology, 2009年11月02日, 査読有り

  
• DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms

  Masayuki Endo; Kumi Hidaka; Takayuki Kato; Keiichi Namba; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009年11月, 査読有り

  
• Chemical Approaches to DNA Nanotechnology

  Masayuki Endo; Hiroshi Sugiyama

  CHEMBIOCHEM, 2009年10月, 査読有り

  
• Reactivity of 5-Halopyrimidines in Nucleic Acids

  Ryu Tashiro; Hiroshi Sugiyama

  Radical and Radical Ion Reactivity in Nucleic Acid Chemistry, 2009年09月28日, 査読有り

  
• Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region

  Hironobu Morinaga; Shin-Ichiro Yonekura; Nobuya Nakamura; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama

  DNA REPAIR, 2009年07月, 査読有り

  
• Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression

  Tsukasa Suzuki; Yukihiro Asami; Teruyuki Takahashi; Xiaofei Wang; Takayoshi Watanabe; Toshikazu Bando; Hiroshi Sugiyama; Noboru Fukuda; Hiroki Nagase

  JOURNAL OF ANTIBIOTICS, 2009年06月, 査読有り

  
• Pharmacokinetic Modeling and Prediction of Plasma Pyrrole-Imidazole Polyamide Concentration in Rats Using Simultaneous Urinary and Biliary Excretion Data

  Takashi Nagashima; Takahiko Aoyama; Tsubasa Yokoe; Akiko Fukasawa; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009年05月, 査読有り

  
• Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry

  Takashi Nagashima; Takahiko Aoyama; Akiko Fukasawa; Satoshi Watabe; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto

  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009年04月, 査読有り

  
• KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli

  Qiu-Mei Zhang-Akiyama; Hironobu Morinaga; Masahiro Kikuchi; Shin-Ichiro Yonekura; Hiroshi Sugiyama; Kazuo Yamamoto; Shuji Yonei

  NUCLEIC ACIDS RESEARCH, 2009年04月, 査読有り

  
• The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides

  Yuta Sannohe; Kyosuke Sato; Akimasa Matsugami; Ken-ichi Shinohara; Tomoko Mashimo; Masato Katahira; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2009年03月, 査読有り

  
• A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function

  Takahiro Ueno; Noboru Fukuda; Akiko Tsunemi; En-Hui Yao; Hiroyuki Matsuda; Kazunobu Tahira; Taro Matsumoto; Koichi Matsumoto; Yoshiaki Matsumoto; Hiroki Nagase; Hiroshi Sugiyama; Tatsuya Sawamura

  JOURNAL OF HYPERTENSION, 2009年03月, 査読有り

  
• Pharmacokinetics of Pyrrole-imidazole Polyamides after Intravenous Administration in Rat

  Akiko Fukasawa; Takahiko Aoyama; Takashi Nagashima; Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto

  BIOPHARMACEUTICS & DRUG DISPOSITION, 2009年03月, 査読有り

  
• A pyrrole-imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery

  E.-H. Yao; N. Fukuda; T. Ueno; H. Matsuda; H. Nagase; Y. Matsumoto; H. Sugiyama; K. Matsumoto

  Cardiovascular Research, 2009年03月, 査読有り

  
• Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design

  Gengo Kashiwazaki; Toshikazu Bando; Ken-ichi Shinohara; Masafumi Minoshima; Shigeki Nishijima; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2009年02月, 査読有り

  
• Erratum: Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (The Journal of Antibiotics (2009) 62 (345) doi:10.1038/ja.2009.42))

  T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase

  Journal of Antibiotics, 2009年, 査読有り

  
• Design of a G-Quadruplex Topology through Glycosidic Bond Angles

  Mateus Webba da Silva; Marko Trajkovski; Yuta Sannohe; Nason Ma'ani Hessari; Hiroshi Sugiyama; Janez Plavec

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009年, 査読有り

  
• Stable Lariat Formation Based on a G-Quadruplex Scaffold

  Yan Xu; Hiroyuki Sato; Yuta Sannohe; Ken-ichi Shinohara; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008年12月, 査読有り

  
• Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe

  Jun Fujimoto; Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Shigeki Nishijima; Ken-ichi Shinohara; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2008年11月, 査読有り

  
• Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression

  Teruyuki Takahashi; Yukihiro Asami; Eiko Kitamura; Tsukasa Suzuki; Xiaofei Wang; Jun Igarashi; Aiko Morohashi; Yui Shinojima; Hisao Kanou; Kosuke Saito; Toshiaki Takasu; Hiroki Nagase; Yuichi Harada; Kazumichi Kuroda; Takayoshi Watanabe; Satoshi Kumamoto; Takahiko Aoyama; Yoshiaki Matsumoto; Toshikazu Bando; Hiroshi Sugiyama; Chikako Yoshida-Noro; Noboru Fukuda; Nariyuki Hayashi

  CHEMISTRY & BIOLOGY, 2008年08月, 査読有り

  
• G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution

  Kenji Okamoto; Yuta Sannohe; Tomoko Mashimo; Hiroshi Sugiyama; Masahide Terazima

  BIOORGANIC & MEDICINAL CHEMISTRY, 2008年07月, 査読有り

  
• Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery After Injury

  En-Hui Yao; Noboru Fukuda; Takahiro Ueno; Hiroyuki Matsuda; Koichi Matsumoto; Hiroki Nagase; Yoshiaki Matsumoto; Ayako Takasaka; Kazuo Serie; Hiroshi Sugiyama; Tatsuya Sawamura

  HYPERTENSION, 2008年07月, 査読有り

  
• Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers

  Jun Fujimoto; Toshikazu Bando; Masafumi Minoshima; Shinsuke Uchida; Makoto Iwasaki; Ken-ichi Shinohara; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2008年06月, 査読有り

  
• Pyrrole-imidazole hairpin polyamides with high affinity at 5CGCG3 DNA sequence; influence of cytosine methylation on binding

  Masafumi Minoshima; Toshikazu Bando; Shunta Sasaki; Jun Fujimoto; Hiroshi Sugiyama

  NUCLEIC ACIDS RESEARCH, 2008年05月, 査読有り

  
• Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition

  Toshikazu Bando; Masafumi Minoshima; Gengo Kashiwazaki; Ken-ichi Shinohara; Shunta Sasaki; Akimichi Ohtsuki; Masataka Murakami; Satomi Nakazono; Hiroshi Suglyarna; Jun Fujimoto

  BIOORGANIC & MEDICINAL CHEMISTRY, 2008年03月, 査読有り

  
• Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides

  Shunta Sasaki; Toshikazu Bando; Masafumi Minoshima; Ken-ichi Shinohara; Hiroshi Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2008年, 査読有り

  
• Photoreaction of iodouracil in DNA duplex; C-I bond is cleaved via two different pathways 'homolysis and heterolysis'

  Ryu Tashiro; Kenta Nakamura; Hiroshi Sugiyama

  TETRAHEDRON LETTERS, 2008年01月, 査読有り

  
• The androgen receptor as putative therapeutic target in hormone-refractory prostate cancer

  Yukio Kageyama; Nobuhiko Hyochi; Kazunori Kihara; Hiroshi Sugiyama

  RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2007年11月, 査読有り

  
• Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma

  Akiko Fukasawa; Takashi Nagashima; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto

  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007年11月, 査読有り

  
• Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides

  Toshikazu Bando; Jun Fujimoto; Masafumi Minoshima; Ken-ichi Shinohara; Shunta Sasaki; Gengo Kashiwazaki; Masatoshi Mizumura; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2007年11月, 査読有り

  
• Recombinant Schizosaccharomyces pombe nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group

  Shin-Ichiro Yonekura; Nobuya Nakamura; Takashi Doi; Hiroshi Sugiyama; Kazuo Yamamoto; Shuji Yonei; Qiu-Mei Zhang

  JOURNAL OF RADIATION RESEARCH, 2007年09月, 査読有り

  
• First International Meeting on Quadruplex DNA

  W. David Wilson; Hiroshi Sugiyama

  ACS CHEMICAL BIOLOGY, 2007年09月, 査読有り

  
• Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solution

  Akimasa Matsugami; Yan Xu; Yuuki Noguchi; Hiroshi Sugiyama; Masato Katahira

  FEBS JOURNAL, 2007年07月, 査読有り

  
• Photoreaction at 5 '-(G/C)AA(Br)UT-3 ' sequence in duplex DNA: Efficent generation of uracil-5-yl radical by charge transfer

  Takayoshi Watanabe; Ryu Tashiro; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007年07月, 査読有り

  
• Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta.

  Masatomi Shimizu; Petr Gruz; Hiroyuki Kamiya; Chikahide Masutani; Yan Xu; Yukio Usui; Hiroshi Sugiyama; Hideyoshi Harashima; Fumio Hanaoka; Takehiko Nohmi

  Biochemistry, 2007年05月08日, 査読有り

  
• Chemical biology that controls DNA structure and function: Lessons in organic chemistry from nature

  Hiroshi Sugiyama

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2007年05月, 査読有り

  
• DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation

  Masafumi Minoshima; Toshikazu Bando; Shunta Sasaki; Ken-ichi Shinohara; Tatsuhiko Shimizu; Jun Fujimoto; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007年05月, 査読有り

  
• I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes

  Yan Xu; Yuuka Hirao; Yoshifumi Nishimura; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2007年02月, 査読有り

  
• Photochemical determination of different DNA structures

  Yan Xu; Ryu Tashiro; Hiroshi Sugiyama

  NATURE PROTOCOLS, 2007年, 査読有り

  
• Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells

  Mikako Hirota; Tsuyoshi Fujiwara; Satoru Mineshita; Hiroshi Sugiyama; Hirobumi Teraoka

  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007年, 査読有り

  
• Synthesis and biological properties of pyrrole-imidazole polyamide conjugates.

  Minoshima M; Sasaki S; Fujimoto J; Shinohara K; Bando T; Sugiyama H

  Nucleic acids symposium series (2004), 2007年, 査読有り

  
• Folding pathways of human telomeric hybrid G-quadruplex structure.

  Mashimo T; Sugiyama H

  Nucleic acids symposium series (2004), 2007年, 査読有り

  
• Sequence-specific alkylation by a tandem motif of pyrrole-imidazole CBI conjugate.

  Sasaki S; Minoshima M; Fujimoto J; Shinohara K; Bando T; Sugiyama H

  Nucleic acids symposium series (2004), 2007年, 査読有り

  
• Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides

  Toshikazu Bando; Hiroshi Sugiyama

  ACCOUNTS OF CHEMICAL RESEARCH, 2006年12月, 査読有り

  
• Base pair recognition of the stereochemically alpha-substituted gamma-turn of pyrrole/imidazole hairpin polyamides

  Wen Zhang; Masafumi Minoshima; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006年11月, 査読有り

  
• Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers

  Shunta Sasaki; Toshikazu Bando; Masafumi Minoshima; Tatsuhiko Shimizu; Ken-ichi Shinohara; Toshiyasu Takaoka; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006年09月, 査読有り

  
• The new models of the human telomere d[AGGG(TTAGGG)(3)] in K+ solution

  Yan Xu; Yuki Noguchi; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2006年08月, 査読有り

  
• Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5 '-TG-3 ' reader in DNA minor groove

  Wen Zhang; Toshikazu Bando; Hiroshi Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006年07月, 査読有り

  
• Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition

  T Bando; S Sasaki; M Minoshima; C Dohno; K Shinohara; A Narita; H Sugiyama

  BIOCONJUGATE CHEMISTRY, 2006年05月, 査読有り

  
• Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element

  Y Kageyama; H Sugiyama; H Ayame; A Iwai; Y Fujii; LE Huang; S Kizaka-Kondoh; M Hiraoka; K Kihara

  ACTA ONCOLOGICA, 2006年04月, 査読有り

  
• Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker

  K Shinohara; T Bando; S Sasaki; Y Sakakibara; M Minoshima; H Sugiyama

  CANCER SCIENCE, 2006年03月, 査読有り

  
• Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta 1 promoter for treatment of progressive renal diseases

  Noboru Fukuda; Takahiro Ueno; Yoshiko Tahira; Hirohito Ayame; Wen Zhang; Toshikazu Bando; Hiroshi Sugiyama; Satoshi Saito; Koichi Matsumoto; Hideo Mugishima; Kazuo Serie

  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006年02月, 査読有り

  
• Photochemical approach to probing different DNA structures

  Y Xu; H Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006年, 査読有り

  
• Alkylation of template strand of coding region causes effective gene silencing

  K Shinohara; S Sasaki; M Minoshima; T Bando; H Sugiyama

  NUCLEIC ACIDS RESEARCH, 2006年, 査読有り

  
• Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

  Y Xu; H Sugiyama

  NUCLEIC ACIDS RESEARCH, 2006年, 査読有り

  
• Synthesis and evaluation of sequence-specific DNA alkylating agents: effect of alkylation subunits.

  Shimizu T; Sasaki S; Minoshima M; Shinohara K; Bando T; Sugiyama H

  Nucleic acids symposium series (2004), 2006年, 査読有り

  
• Molecular design of DNA alkylating pyrrole-imidazole polyamides with longer recognition sequence.

  Minoshima M; Sasaki S; Shinohara K; Shimizu T; Bando T; Sugiyama H

  Nucleic acids symposium series (2004), 2006年, 査読有り

  
• Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta 1 gene

  YM Lai; N Fukuda; T Ueno; H Matsuda; S Saito; K Matsumoto; H Ayame; T Bando; H Sugiyama; H Mugishima; K Serie

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005年11月, 査読有り

  
• The chemical biology that controls DNA function and structure

  T Bando; H Sugiyama

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2005年10月, 査読有り

  
• Specific adenine alkylation by pyrrole-imidazole CBI conjugates

  T Bando; A Narita; S Sasaki; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005年10月, 査読有り

  
• UVR-induced G-C to C-G transversions from oxidative DNA damage

  K Kino; H Sugiyama

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005年04月, 査読有り

  
• 5-Exo versus 6-endo cyclization of nucleoside 2-sila-5-hexenyl radicals: Reaction of 6-(bromomethyl)dimethylsilyl 1 ',2 '-unsaturated uridines

  J Ogamino; H Mizunuma; H Kumamoto; S Takeda; K Haraguchi; KT Nakamura; H Sugiyama; H Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, 2005年03月, 査読有り

  
• Biomolecule-based switching devices that respond inversely to thermal stimuli

  R Tashiro; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005年02月, 査読有り

  
• DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNElL1 and hNTH1 enzymes in human cells

  QM Zhang; S Yonekura; M Takao; A Yasui; H Sugiyama; S Yonei

  DNA REPAIR, 2005年01月, 査読有り

  
• Efficient generation of 2 '-deoxyuridin-5-yl at 5 '(G/C)AA(x)U(x)U-3 ' (X = Br, I) sequences in duplex DNA under UV irradiation

  T Watanabe; T Bando; Y Xu; R Tashiro; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005年01月, 査読有り

  
• Binding of distamycin A to UV-damaged DNA

  A Inase; TS Kodama; J Sharif; Y Xu; H Ayame; H Sugiyama; S Iwai

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年09月, 査読有り

  
• Enantioselective DNA alkylation by a pyrrole-imidazole S-CIB conjugate

  T Bando; A Narita; K Asada; H Ayame; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年07月, 査読有り

  
• (P)-helicene displays chiral selection in binding to Z-DNA

  Y Xu; YX Zhang; H Sugiyama; T Umano; H Osuga; K Tanaka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年06月, 査読有り

  
• Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-lodouracil-containing antiparallel G-quartet

  Y Xu; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年05月, 査読有り

  
• Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides

  K Shinohara; A Narita; T Oyoshi; T Bando; H Teraoka; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年04月, 査読有り

  
• Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide

  MSRC Murty; H Sugiyama

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2004年04月, 査読有り

  
• Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.

  Katsuhito Kino; Yuichiro Shimizu; Kaoru Sugasawa; Hiroshi Sugiyama; Fumio Hanaoka

  Biochemistry, 2004年03月16日, 査読有り

  
• C-H to N substitution dramatically alters the sequence-specific DNA alkylation, cytotoxicity, and expression of human cancer cell lines

  T Bando; A Narita; A Iwai; K Kihara; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004年03月, 査読有り

  
• Unique charge transfer properties of the four-base pi-stacks in Z-DNA

  R Tashiro; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003年12月, 査読有り

  
• 8-methylguanosine: A powerful Z-DNA stabilizer

  Y Xu; R Ikeda; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003年11月, 査読有り

  
• Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides

  T Bando; H Iida; ZF Tao; A Narita; N Fukuda; T Yamori; H Sugiyama

  CHEMISTRY & BIOLOGY, 2003年08月, 査読有り

  
• Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide

  R Takahashi; T Bando; H Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2003年06月, 査読有り

  
• Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases AP lyases in Saccharomyces cerevisiae

  QM Zhang; K Hashiguchi; K Kino; H Sugiyama; S Yonei

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2003年05月, 査読有り

  
• Inhibition of transcription at a coding sequence by alkylating polyamide

  T Oyoshi; W Kawakami; A Narita; T Bando; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003年04月, 査読有り

  
• Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates

  T Bando; A Narita; Saito, I; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003年03月, 査読有り

  この論文にアクセスする：

  
• Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases

  M Hori; S Yonei; H Sugiyama; K Kino; K Yamamoto; QM Zhang

  NUCLEIC ACIDS RESEARCH, 2003年02月, 査読有り

  
• Efficient C2 'alpha-hydroxylation of deoxyribose in protein-induced Z-form DNA

  T Oyoshi; K Kawai; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003年02月, 査読有り

  
• Photoreactivity of 5-iodouracil-containing telomeric DNA.

  Xu Y; Sugiyama H

  Nucleic acids research. Supplement (2001), 2003年, 査読有り

  
• Photochemistry of bromouracil containing Z-DNA.

  Tashiro R; Sugiyama H

  Nucleic acids research. Supplement (2001), 2003年, 査読有り

  
• Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides.

  Ayame H; Saito T; Bando T; Fukuda N; Sugiyama H

  Nucleic acids research. Supplement (2001), 2003年, 査読有り

  
• Towards artificial repair of UV-damaged DNA: studies on drug binding and alkali hydrolysis.

  Iwai S; Inase A; Jafar S; Higurashi M; Ohtsuki T; Xu Y; Sugiyama H

  Nucleic acids research. Supplement (2001), 2003年, 査読有り

  
• A nanothermometer based on the different pi stackings of B- and Z-DNA

  R Tashiro; H Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003年, 査読有り

  
• Deglyco-peplomycin metal complexes on DNA fibers: a role of the sugar moiety for the stability and the orientation of the complexes

  T Iiyama; M Chikira; T Oyoshi; H Sugiyama

  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2003年01月, 査読有り

  
• Molecular design of hairpin pyrrole-imidazole polyamides possessing sequence specific DNA alkylating moiety.

  Narita A; Bando T; Sugiyama H

  Nucleic acids research. Supplement (2001), 2003年, 査読有り

  
• The conformational study of two carbocyclic nucleosides: Why carbocyclic nucleic acids (CarNAs) form more stable duplexes with RNA than DNA does

  Y Xu; K Kino; H Sugiyama

  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2002年12月, 査読有り

  
• Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation

  T Bando; A Narita; Saito, I; H Sugiyama

  CHEMISTRY-A EUROPEAN JOURNAL, 2002年10月, 査読有り

  この論文にアクセスする：

  
• Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates

  K Fujimoto; H Iida; M Kawakami; T Bando; ZF Tao; H Sugiyama

  NUCLEIC ACIDS RESEARCH, 2002年09月, 査読有り

  
• Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein

  Miyabe, I; QM Zhang; K Kino; H Sugiyama; M Takao; A Yasui; S Yonei

  NUCLEIC ACIDS RESEARCH, 2002年08月, 査読有り

  
• Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein

  K Hashiguchi; QM Zhang; H Sugiyama; S Ikeda; S Yonei

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2002年07月, 査読有り

  
• Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: The protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5 ' side

  T Oyoshi; AHJ Wang; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002年03月, 査読有り

  
• Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: The protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5 ' side

  T Oyoshi; AHJ Wang; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002年03月, 査読有り

  
• Molecular design of hairpin polyamide possessing sequence-specific alkylation activity.

  Narita A; Bando T; Sugiyama H

  Nucleic acids research. Supplement (2001), 2002年, 査読有り

  
• Regulation of gene expression by sequence-specific alkylating polyamide.

  Oyoshi T; Kawakami W; Bando T; Narita A; Sugiyama H

  Nucleic acids research. Supplement (2001), 2002年, 査読有り

  
• A third arm on the chest: Implications for the cortical reorganization theory of phantom limbs [8]

  Yu Sakagami; Toshiya Murai; Hiroshi Sugiyama

  Journal of Neuropsychiatry and Clinical Neurosciences, 2002年, 査読有り

  
• Photoreactivity of 5-iodouracil-containing DNA-Z  complex

  T. Oyoshi; H. Sugiyama

  Nucleic Acids Symposium Series, 2001年11月01日

  
• 出芽酵母粗抽出液からの8-oxoG結合活性の検出

  橋口 一成; 張 秋梅; 杉山 弘; 米井 脩治

  日本放射線影響学会大会講演要旨集, 2001年10月

  
• Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides

  T Fujiwara; M Kimoto; H Sugiyama; Hirao, I; S Yokoyama

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001年08月, 査読有り

  
• Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders

  PG Baraldi; G Balboni; MG Pavani; G Spalluto; MA Tabrizi; E De Clercq; J Balzarini; T Bando; H Sugiyama; R Romagnoli

  JOURNAL OF MEDICINAL CHEMISTRY, 2001年08月, 査読有り

  
• Sequence-specific DNA interstrand cross-linking by imidazole-pyrrole CPI conjugate

  T Bando; H Iida; Saito, I; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001年05月, 査読有り

  この論文にアクセスする：

  
• Possible cause of G center dot C -> C center dot G transversion mutation by guanine oxidation product, imidazolone

  K Kino; H Sugiyama

  CHEMISTRY & BIOLOGY, 2001年04月, 査読有り

  
• Amplification of bleomycin-induced DNA cleavage at cytosine residues 3 ' to GGG sequences by pyrrole triamide

  Y Hiraku; S Oikawa; K Kuroki; H Sugiyama; Saito, I; S Kawanishi

  BIOCHEMICAL PHARMACOLOGY, 2001年02月, 査読有り

  この論文にアクセスする：

  
• Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli

  Miyabe, I; QM Zhang; H Sugiyama; K Kino; S Yonei

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2001年01月, 査読有り

  
• Identification of repair enzymes for 5-formyluracil in DNA - Nth, Nei, and MutM proteins of Escherichia coli

  QM Zhang; Miyabe, I; Y Matsumoto; K Kino; H Sugiyama; S Yonei

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2000年11月, 査読有り

  
• Recognition of DNA sequences by pyrrole-imidazole polyamide: Rational drug design in the post-genome era

  H Iida; H Sugiyama

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2000年10月, 査読有り

  
• Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations

  S Kawanishi; S Oikawa; M Kawanishi; H Sugiyama; Saito, I; L Strekowski; WD Wilson

  BIOCHEMISTRY, 2000年10月, 査読有り

  この論文にアクセスする：

  
• Mechanism of DNA strand scission induced by (1,10-phenanthroline)copper complex: Major direct DNA cleavage is not through 1 ',2 '-dehydronucleotide intermediate nor beta-elimination of forming ribonolactone

  T Oyoshi; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000年07月, 査読有り

  
• Metallo-bleomycin cleaves parallel-stranded DNA similarly to B-DNA

  S Ikeda; Saito, I; H Sugiyama

  TETRAHEDRON LETTERS, 2000年05月, 査読有り

  この論文にアクセスする：

  
• Enhanced cytotoxicity in a Z-photoisomer of a benzopyran derivative of propolis

  M Hirota; T Matsuno; T Fujiwara; H Sugiyama; S Mineshita

  JOURNAL OF NATURAL PRODUCTS, 2000年03月, 査読有り

  
• Highly cooperative DNA dialkylation by the homodimer of imidazole-pyrrole diamide-CPI conjugate with vinyl linker

  ZF Tao; Saito, I; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000年03月, 査読有り

  この論文にアクセスする：

  
• Imidazole-imidazole pair as a minor groove recognition motif for T : G mismatched base pairs

  XL Yang; RB Hubbard; M Lee; ZF Tao; H Sugiyama; AHJ Wang

  NUCLEIC ACIDS RESEARCH, 1999年11月, 査読有り

  
• State transitions by molecules

  K Sakamoto; D Kiga; K Komiya; H Gouzu; S Yokoyama; S Ikeda; H Sugiyama; M Hagiya

  BIOSYSTEMS, 1999年10月, 査読有り

  
• Modulation of sequence specificity of duocarmycin-dependent DNA alkylation by pyrrole-imidazole triamides

  T Fujiwara; ZF Tao; Y Ozeki; Saito, I; AHJ Wang; M Lee; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999年08月, 査読有り

  
• Substrate recognition by Escherichia coli MutY using substrate analogs

  CL Chepanoske; SL Porello; T Fujiwara; H Sugiyama; SS David

  NUCLEIC ACIDS RESEARCH, 1999年08月, 査読有り

  
• Photochemical halogen-exchange reaction of 5-iodouracil-containing oligonucleotides

  Kiyohiko Kawai; Isao Saito; Hiroshi Sugiyama

  Tetrahedron Letters, 1999年07月30日, 査読有り

  
• Rational design of sequence-specific DNA alkylating agents based on duocarmycin A and pyrrole-imidazole hairpin polyamides

  ZF Tao; T Fujiwara; Saito, I; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999年06月, 査読有り

  
• Intrastrand 2 'beta hydrogen abstraction of 5 '-adjacent deoxyguanosine by deoxyuridin-5-yl in Z-form DNA

  K Kawai; Saito, I; E Kawashima; Y Ishido; H Sugiyama

  TETRAHEDRON LETTERS, 1999年03月, 査読有り

  
• Conformation-dependent photochemistry of 5-halouracil-containing DNA: Stereospecific 2 'alpha-hydroxylation of deoxyribose in Z-form DNA

  K Kawai; Saito, I; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999年02月, 査読有り

  
• Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides

  QM Zhang; H Sugiyama; Miyabe, I; S Matsuda; K Kino; Saito, I; S Yonei

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1999年01月, 査読有り

  
• Sequence-specific DNA alkylation by hybrid molecules between segment a of duocarmycin A and pyrrole/imidazole diamide

  ZF Tao; T Fujiwara; Saito, I; H Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1999年, 査読有り

  
• Sequence-specific alkylation of DNA by duocarmycin A and its novel derivatives bearing PY/IM polyamides

  ZF Tao; T Fujiwara; Saito, I; H Sugiyama

  NUCLEOSIDES & NUCLEOTIDES, 1999年, 査読有り

  
• Mapping of the hot spots for DNA damage by one-electron oxidation: Efficacy of GG doublets and GGG triplets as a trap in long-range hole migration

  Saito, I; T Nakamura; K Nakatani; Y Yoshioka; K Yamaguchi; H Sugiyama

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998年12月, 査読有り

  
• Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine : cytosine and isocytosine : guanine basepairs by nuclear magnetic resonance spectroscopy

  XL Yang; H Sugiyama; S Ikeda; Saito, I; AHJ Wang

  BIOPHYSICAL JOURNAL, 1998年09月, 査読有り

  
• Facile synthesis of puromycin-tethered oligonucleotides at the 3 '-end

  S Ikeda; Saito, I; H Sugiyama

  TETRAHEDRON LETTERS, 1998年08月, 査読有り

  
• Stabilization of Hoogsteen base pairing by introduction of NH2 group at the C8 position of adenine

  Kiyohiko Kawai; Isao Saito; Hiroshi Sugiyama

  Tetrahedron Letters, 1998年07月16日, 査読有り

  
• Sequence dependent photoreduction of 5-bromouracil-containing oligonucleotides via electron transfer

  Kenzo Fujimoto; Hiroshi Sugiyama; Isao Saito

  Tetrahedron Letters, 1998年04月, 査読有り

  
• Molecular mechanism of GG-specific photooxidation of DNA

  Katsuhito Kino; Hiroshi Sugiyama

  Journal of Medical and Dental Sciences, 1998年, 査読有り

  
• Preferential C1' hydrogen abstraction by a uracilyl radical in a DNA-RNA hybrid

  H Sugiyama; K Fujimoto; Saito, I

  TETRAHEDRON LETTERS, 1997年11月, 査読有り

  
• Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA

  QM Zhang; H Sugiyama; Miyabe, I; S Matsuda; Saito, I; S Yonei

  NUCLEIC ACIDS RESEARCH, 1997年10月, 査読有り

  
• Interactions of deglycosylated cobalt(III) - Pepleomycin (green form) with DNA based on NMR structural studies

  J CaceresCortes; H Sugiyama; K Ikudome; Saito, I; AHJ Wang

  BIOCHEMISTRY, 1997年08月, 査読有り

  
• Design of photochemical DNA-cleaving molecules via electron transfer

  Saito, I; M Takayama; H Sugiyama; T Nakamura

  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1997年06月, 査読有り

  
• Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies

  J CaceresCortes; H Sugiyama; K Ikudome; Saito, I; AHJ Wang

  EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997年03月, 査読有り

  
• New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior

  H Sugiyama; S Matsuda; K Kino; QM Zhang; S Yonei; Saito, I

  TETRAHEDRON LETTERS, 1996年12月, 査読有り

  
• Remarkably stable parallel-stranded oligonucleotides containing 5-methylisocytosine and isoguanine

  H Sugiyama; S Ikeda; Saito, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996年10月, 査読有り

  
• Catalytic activities of hammerhead ribozymes with a triterpenoid linker instead of stem/loop II

  H Sugiyama; K Hatano; Saito, I; S Amontov; K Taira

  FEBS LETTERS, 1996年09月, 査読有り

  
• Theoretical studies of GC-specific photocleavage of DNA via electron transfer: Significant lowering of ionization potential and 5'-localization of HOMO of stacked GG bases in B-form DNA

  H Sugiyama; Saito, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996年07月, 査読有り

  
• Synthesis, structure and thermodynamic properties of 8-methylguanine-containing oligonucleotides: Z-DNA under physiological salt conditions

  H Sugiyama; K Kawai; A Matsunaga; K Fujimoto; Saito, I; H Robinson; AHJ Wang

  NUCLEIC ACIDS RESEARCH, 1996年04月, 査読有り

  
• Evidence for intrastrand C2' hydrogen abstraction in photoirradiation of 5-halouracil-containing oligonucleotides by using stereospecifically C2'-deuterated deoxyadenosine

  H Sugiyama; K Fujimoto; Saito, I

  TETRAHEDRON LETTERS, 1996年03月, 査読有り

  
• Design of photoactivatable DNA-cleaving amino acids with high sequence selectivity - Guanine-guanine stacking rule for electron-transfer from DNA

  Saito, I; M Takayama; H Sugiyama; T Nakamura

  DNA AND RNA CLEAVERS AND CHEMOTHERAPY OF CANCER AND VIRAL DISEASES, 1996年, 査読有り

  
• STEREOSPECIFIC 1,2-HYDRIDE SHIFT IN RIBONOLACTONE FORMATION IN THE PHOTOREACTION OF 2'-IODODEOXYURIDINE

  H SUGIYAMA; K FUJIMOTO; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995年03月, 査読有り

  
• Mechanism of oxidative DNA strand scission

  H. Sugiyama

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1995年, 査読有り

  
• NMR characterization of guanine DNA site alkylated by kapurimycin A3, an antitumour antibiotic from Streptomyces sp.

  K. L. Chan; H. Sugiyama; I. Saito; M. Hara

  Phytochemistry, 1995年, 査読有り

  
• OLIGONUCLEOTIDES CONTAINING A RADICAL TRAP - THE TRAPPING OF DEOXYRIBOSE C4' RADICAL IN BLEOMYCIN-MEDIATED REACTIONS

  H SUGIYAMA; K OHMORI; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994年11月, 査読有り

  
• ACTIVATION OF NEOCARZINOSTATIN-CHROMOPHORE BY 4-HYDROXYTHIOPHENOL - INTRAMOLECULAR RADICAL TRAPPING OF BIRADICAL INTERMEDIATE

  H SUGIYAMA; T FUJIWARA; SAITO, I

  TETRAHEDRON LETTERS, 1994年11月, 査読有り

  
• CHEMISTRY OF THERMAL-DEGRADATION OF ABASIC SITES IN DNA - MECHANISTIC INVESTIGATION ON THERMAL DNA STRAND CLEAVAGE OF ALKYLATED DNA

  H SUGIYAMA; T FUJIWARA; A URA; T TASHIRO; K YAMAMOTO; S KAWANISHI; SAITO, I

  CHEMICAL RESEARCH IN TOXICOLOGY, 1994年09月, 査読有り

  
• APOPROTEIN-ASSISTED UNUSUAL CYCLIZATION OF NEOCARZINOSTATIN CHROMOPHORE

  H SUGIYAMA; K YAMASHITA; T FUJIWARA; SAITO, I

  TETRAHEDRON, 1994年01月, 査読有り

  
• THE SCID MUTATION IN MICE CAUSES DEFECTS IN THE REPAIR SYSTEM FOR BOTH DOUBLE-STRAND DNA BREAKS AND DNA CROSS-LINKS

  T TANAKA; T YAMAGAMI; Y OKA; T NOMURA; H SUGIYAMA

  MUTATION RESEARCH, 1993年08月, 査読有り

  
• PHOTOINDUCED DEOXYRIBOSE-C2' OXIDATION IN DNA - ALKALI-DEPENDENT CLEAVAGE OF ERYTHROSE-CONTAINING SITES VIA A RETROALDOL REACTION

  H SUGIYAMA; Y TSUTSUMI; K FUJIMOTO; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993年06月, 査読有り

  
• A NOVEL GUANINE N3 ALKYLATION BY ANTITUMOR ANTIBIOTIC DUOCARMYCIN-A

  H SUGIYAMA; K OHMORI; KL CHAN; M HOSODA; A ASAI; H SAITO; SAITO, I

  TETRAHEDRON LETTERS, 1993年03月, 査読有り

  
• CONCERTED DNA RECOGNITION AND NOVEL SITE-SPECIFIC ALKYLATION BY DUOCARMYCIN-A WITH DISTAMYCIN-A

  K YAMAMOTO; H SUGIYAMA; S KAWANISHI

  BIOCHEMISTRY, 1993年02月, 査読有り

  
• PHOTOCHEMISTRY OF 5-HALOURACIL-CONTAINING DNA

  H SUGIYAMA; Y TSUTSUMI; E YAMAGUCHI; SAITO, I

  FRONTIERS OF PHOTOBIOLOGY, 1993年, 査読有り

  
• 6-ALPHA-HYDROXYEURYCOMALACTONE, A QUASSINOID FROM EURYCOMA-LONGIFOLIA

  KL CHAN; Y IITAKA; H NOGUCHI; H SUGIYAMA; SAITO, I; U SANKAWA

  PHYTOCHEMISTRY, 1992年12月, 査読有り

  
• CHEMISTRY OF NEOCARZINOSTATIN-MEDIATED CLEAVAGE OF OLIGONUCLEOTIDES - COMPETITIVE RIBOSE C5' AND C4' HYDROXYLATION

  H SUGIYAMA; T FUJIWARA; H KAWABATA; N YODA; N HIRAYAMA; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992年07月, 査読有り

  
• ANTISCHISTOSOMAL ACTIVITIES OF SESQUITERPENE LACTONES AND STEROID GLUCOSIDES FROM VERNONIA-AMYGDALINA, POSSIBLY USED BY WILD CHIMPANZEES AGAINST PARASITE-RELATED DISEASES

  M JISAKA; M KAWANAKA; H SUGIYAMA; K TAKEGAWA; MA HUFFMAN; H OHIGASHI; K KOSHIMIZU

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992年05月, 査読有り

  
• A NOVEL CYCLIZATION PATHWAY IN ACTIVATION OF NEOCARZINOSTATIN CHROMOPHORE BY THIOL UNDER PHYSIOLOGICAL CONDITIONS

  H SUGIYAMA; K YAMASHITA; M NISHI; SAITO, I

  TETRAHEDRON LETTERS, 1992年01月, 査読有り

  
• DNA cleavage reaction of antitumour antibiotic, kapurimycin A3, with deoxytetranucleotide d(CGCG)2

  Kit Lam Chan; Hiroshi Sugiyama; Isao Saito; Mitsunobu Hara

  Tetrahedron Letters, 1991年12月23日, 査読有り

  
• BIS(HYDROPEROXY)NAPHTHALDIIMIDE AS A PHOTO-FENTON REAGENT - SEQUENCE-SPECIFIC PHOTOCLEAVAGE OF DNA

  S MATSUGO; S KAWANISHI; K YAMAMOTO; H SUGIYAMA; T MATSUURA; SAITO, I

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991年10月, 査読有り

  
• BLEOMYCIN-MEDIATED DEGRADATION OF ARISTEROMYCIN-CONTAINING DNA - NOVEL DEHYDROGENATION ACTIVITY OF IRON(II) BLEOMYCIN

  H SUGIYAMA; T SERA; Y DANNOUE; R MARUMOTO; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991年03月, 査読有り

  
• HIGHLY SEQUENCE SELECTIVE PHOTOREACTION OF 5-BROMOURACIL-CONTAINING DEOXYHEXANUCLEOTIDES

  H SUGIYAMA; Y TSUTSUMI; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990年08月, 査読有り

  
• SPECIFIC DETECTION OF C-4' HYDROXYLATED ABASIC SITES GENERATED BY BLEOMYCIN AND NEOCARZINOSTATIN IN DNA

  H SUGIYAMA; H KAWABATA; T FUJIWARA; Y DANNOUE; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990年06月, 査読有り

  
• COVALENT ALKYLATION OF DNA WITH DUOCARMYCIN-A - IDENTIFICATION OF ABASIC SITE STRUCTURE

  H SUGIYAMA; M HOSODA; SAITO, I; A ASAI; H SAITO

  TETRAHEDRON LETTERS, 1990年, 査読有り

  
• ANNEALING EFFECT ON LATTICE DISTORTION IN ANODIZED POROUS SILICON LAYERS

  H SUGIYAMA; O NITTONO

  JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS, 1989年11月, 査読有り

  
• A NOVEL RIBOSE C-4' HYDROXYLATION PATHWAY IN NEOCARZINOSTATIN-MEDIATED DEGRADATION OF OLIGONUCLEOTIDES

  SAITO, I; H KAWABATA; T FUJIWARA; H SUGIYAMA; T MATSUURA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989年10月, 査読有り

  
• SYNTHETIC COBALT BLEOMYCIN MODELS AS A PHOTOCHEMICAL DNA CLEAVER

  SAITO, I; T MORII; T OBAYASHI; T SERA; H SUGIYAMA; T MATSUURA

  JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989年03月, 査読有り

  
• PHOTOINDUCED DNA STRAND SCISSION BY COBALT BLEOMYCIN GREEN COMPLEX

  SAITO, I; T MORII; H SUGIYAMA; T MATSUURA; CF MEARES; SM HECHT

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989年03月, 査読有り

  
• OXIDATIVE STRAND SCISSION OF DNA

  T MATSUURA; SAITO, I; H SUGIYAMA; T MORII; H KAWABATA

  PURE AND APPLIED CHEMISTRY, 1989年03月, 査読有り

  
• CHARACTERIZATION OF POROUS SILICON LAYERS BY MEANS OF X-RAY DOUBLE-CRYSTAL DIFFRACTOMETRY

  H SUGIYAMA; O NITTONO

  ISIJ INTERNATIONAL, 1989年, 査読有り

  
• METALLO-BLEOMYCIN-MEDIATED DEGRADATION OF DEOXYTETRANUCLEOTIDES - UNUSUAL C-4' HYDROXYLATION AT TERMINAL CYTIDINE

  H SUGIYAMA; T TASHIRO; Y DANNOUE; T MIWA; T MATSUURA; SAITO, I

  TETRAHEDRON LETTERS, 1989年, 査読有り

  
• CHEMISTRY OF NEOCARZINOSTATIN-MEDIATED DEGRADATION OF D(GCATGC) - MECHANISM OF SPONTANEOUS THYMINE RELEASE

  H KAWABATA; H TAKESHITA; T FUJIWARA; H SUGIYAMA; T MATSUURA; SAITO, I

  TETRAHEDRON LETTERS, 1989年, 査読有り

  
• EXCITED-STATE BEHAVIOR OF TRYPTAMINE AND RELATED INDOLES - REMARKABLY EFFICIENT INTRAMOLECULAR PROTON-INDUCED QUENCHING

  H SHIZUKA; M SERIZAWA; H KOBAYASHI; K KAMETA; H SUGIYAMA; T MATSUURA; SAITO, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988年03月, 査読有り

  
• CHEMISTRY OF THE ALKALI-LABILE LESION FORMED FROM IRON(II) BLEOMYCIN AND D(CGCTTTAAAGCG)

  H SUGIYAMA; C XU; N MURUGESAN; SM HECHT; GA VANDERMAREL; JH VANBOOM

  BIOCHEMISTRY, 1988年01月, 査読有り

  
• COPPER-DEPENDENT CLEAVAGE OF DNA BY BLEOMYCIN

  GM EHRENFELD; JB SHIPLEY; DC HEIMBROOK; H SUGIYAMA; EC LONG; JH VANBOOM; GA VANDERMAREL; NJ OPPENHEIMER; SM HECHT

  BIOCHEMISTRY, 1987年02月, 査読有り

  
• DNA STRAND SCISSION BY BLEOMYCIN - CATALYTIC CLEAVAGE AND STRAND SELECTIVITY

  H SUGIYAMA; RE KILKUSKIE; LH CHANG; LT MA; SM HECHT; GA VANDERMAREL; JH VANBOOM

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986年06月, 査読有り

  
• PERIODIC ACID-SCHIFF (PAS)-POSITIVE, ANTIGRANULOCYTES STRUCTURES INCREASE IN THE BRAIN OF SENESCENCE ACCELERATED MOUSE (SAM)

  H AKIYAMA; M KAMEYAMA; AKIGUCHI, I; H SUGIYAMA; T KAWAMATA; H FUKUYAMA; H KIMURA; M MATSUSHITA; T TAKEDA

  ACTA NEUROPATHOLOGICA, 1986年, 査読有り

  
• DNA STRAND SCISSION BY BLEOMYCIN GROUP ANTIBIOTICS

  H SUGIYAMA; GM EHRENFELD; JB SHIPLEY; RE KILKUSKIE; LH CHANG; SM HECHT

  JOURNAL OF NATURAL PRODUCTS, 1985年11月, 査読有り

  
• STACKING INTERACTION BETWEEN TRYPTOPHAN AND URACIL IN A SYNTHETIC MODEL-COMPOUND

  SAITO, I; H SUGIYAMA; T MATSUURA; K FUKUYAMA

  TETRAHEDRON LETTERS, 1985年, 査読有り

  
• AN EFFICIENT, SITE-SPECIFIC DNA TARGET FOR BLEOMYCIN

  H SUGIYAMA; RE KILKUSKIE; SM HECHT; GA VANDERMAREL; JH VANBOOM

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985年, 査読有り

  
• PHOTOINDUCED REACTIONS .165. REGIO-CONTROLLED HYDROGEN-DEUTERIUM EXCHANGE OF BIOLOGICALLY IMPORTANT INDOLES UNDER UV IRRADIATION

  SAITO, I; S MURAMATSU; H SUGIYAMA; A YAMAMOTO; T MATSUURA

  TETRAHEDRON LETTERS, 1985年, 査読有り

  
• ANALYSIS OF PRODUCTS FORMED DURING BLEOMYCIN-MEDIATED DNA-DEGRADATION

  N MURUGESAN; C XU; GM EHRENFELD; H SUGIYAMA; RE KILKUSKIE; LO RODRIGUEZ; LH CHANG; SM HECHT

  BIOCHEMISTRY, 1985年, 査読有り

  
• STRUCTURE OF THE ALKALI-LABILE PRODUCT FORMED DURING IRON(II)-BLEOMYCIN-MEDIATED DNA STRAND SCISSION

  H SUGIYAMA; C XU; N MURUGESAN; SM HECHT

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985年, 査読有り

  
• A NEW PROCEDURE FOR DETERMINING THYMINE RESIDUES IN DNA SEQUENCING - PHOTOINDUCED CLEAVAGE OF DNA FRAGMENTS IN THE PRESENCE OF SPERMINE

  SAITO, I; H SUGIYAMA; T MATSUURA; K UEDA; T KOMANO

  NUCLEIC ACIDS RESEARCH, 1984年, 査読有り

  
• PHOTOINDUCED REACTIONS .159. PHOTOCHEMICAL-REACTION BETWEEN TRYPTOPHAN AND THYMINE

  SAITO, I; H SUGIYAMA; T MATSUURA; K FUKUYAMA; Y KATSUBE

  TETRAHEDRON LETTERS, 1984年, 査読有り

  
• PHOTOCHEMICAL HYDROGEN-DEUTERIUM EXCHANGE-REACTION OF TRYPTOPHAN - THE ROLE IN NONRADIATIVE DECAY OF SINGLET TRYPTOPHAN

  SAITO, I; H SUGIYAMA; A YAMAMOTO; S MURAMATSU; T MATSUURA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984年, 査読有り

  
• PHOTOINDUCED REACTIONS .151. ISOLATION AND CHARACTERIZATION OF A THYMINE-LYSINE ADDUCT IN UV-IRRADIATED NUCLEI - THE ROLE OF THYMINE LYSINE PHOTOADDITION IN PHOTO-CROSS-LINKING OF PROTEINS TO DNA

  SAITO, I; H SUGIYAMA; T MATSUURA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983年, 査読有り

  
• PHOTOREACTION OF THYMIDINE WITH ALKYLAMINES - APPLICATION TO SELECTIVE REMOVAL OF THYMINE FROM DNA

  SAITO, I; H SUGIYAMA; T MATSUURA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983年, 査読有り

  
• PHOTOINDUCED REACTIONS .133. PHOTOCHEMICAL RING-OPENING OF THYMIDINE AND THYMINE IN THE PRESENCE OF PRIMARY AMINES

  SAITO, I; H SUGIYAMA; N FURUKAWA; T MATSUURA

  TETRAHEDRON LETTERS, 1981年, 査読有り

  
• PHOTOINDUCED REACTIONS .130. A NOVEL PHOTOREACTION OF THYMIDINE WITH - PHOTOINDUCED MIGRATION OF THYMINE FROM DNA TO LYSINE

  SAITO, I; H SUGIYAMA; S ITO; N FURUKAWA; T MATSUURA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981年, 査読有り

  
• ELECTROORGANIC CHEMISTRY .49. ELECTROREDUCTIVE HYDROCOUPLING OF ACTIVATED OLEFINS WITH KETONES OR ALDEHYDES IN THE PRESENCE OF TRIMETHYLCHLOROSILANE

  T SHONO; H OHMIZU; S KAWAKAMI; H SUGIYAMA

  TETRAHEDRON LETTERS, 1980年, 査読有り

  
• ORGANIC-CHEMICAL APPROACH TO PHOTO-CROSS-LINKS OF NUCLEIC-ACIDS TO PROTEINS

  T MATSUURA; SAITO, I; S ITO; H SUGIYAMA; T SHINMURA

  PURE AND APPLIED CHEMISTRY, 1980年, 査読有り

  
• Photochemical reaction of 8-azaxanthine with nucleophiles

  I. Saito; S. Ito; H. Sugiyama; M. Akita; T. Matsuura

  Tetrahedron Letters, 1979年, 査読有り

  
• Elastic properties of (NH₄)₂SO₄ in the paraelectrlc region

  N. Nakanishi; Y. Murakami; M. Tobioka; H. Sugiyama; S. Kachi

  Journal of the Physical Society of Japan, 1973年, 査読有り

  
• Syntheses and reactions of deuterated troponoids

  S. Ito; J. Tsunetsugu; T. Kanno; H. Sugiyama; H. Takeshita

  Tetrahedron Letters, 1966年, 査読有り