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Graduate School of Medicine Program-Specific Associate Professor

list
    Last Updated :2025/04/23

    Basic Information

    Academic Degree

    • 博士（医学）(京都大学)

    Academic Resume (Undergraduate School/Majors)

    • 北海道大学, 獣医学部獣医学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2025/04/23

      Research

      Research Areas

      • Life sciences, Tumor biology

      Papers

      • 患者検体より採取した胃癌細胞由来球体細胞(スフェロイド)の効果的な新規培養法
        森本 智紀; 山本 健人; 前川 久継; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 三好 弘之; 武藤 誠; 小濱 和貴
        日本消化器外科学会雑誌, Nov. 2023
      • Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch.
        Yuki Aisu; Nobu Oshima; Fuminori Hyodo; Abdelazim Elsayed Elhelaly; Akihiko Masuo; Tomoaki Okada; Shigeo Hisamori; Shigeru Tsunoda; Koya Hida; Tomonori Morimoto; Hiroyuki Miyoshi; Makoto M Taketo; Masayuki Matsuo; Leonard M Neckers; Yoshiharu Sakai; Kazutaka Obama
        PloS one, 2024
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      • 患者検体より採取した胃癌細胞由来スフェロイドの胃癌個別化治療選択ツールとしての有効性
        森本 智紀; 安 英男; 山本 健人; 坂本 享史; 奥村 慎太郎; 前川 久継; 笠原 桂子; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 柿崎 文彦; 三好 弘之; 武藤 誠; 小濱 和貴
        日本外科学会定期学術集会抄録集, Apr. 2024
      • O-013 Defining the Basis of Epithelial Defects in Crohn's Using Intestinal Spheroid Culture
        VanDussen, K.; Miyoshi, H.; Sonnek, N.; Ciorba, M.; Stappenbeck, T.
        Inflamm Bowel Dis, 2016
      • Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis
        Jansen, M.; de Leng, W. W.; Baas, A. F.; Myoshi, H.; Mathus-Vliegen, L.; Taketo, M. M.; Clevers, H.; Giardiello, F. M.; Offerhaus, G. J.
        Gut, 2006
      • 患者検体より採取した胃癌細胞由来球体細胞(スフェロイド)の効果的培養法
        森本 智紀; 山本 健人; 前川 久継; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 三好 弘之; 武藤 誠; 小濱 和貴
        日本消化器外科学会総会, Jul. 2023
      • 患者検体より採取した胃癌細胞由来球体細胞(spheroid)の効果的培養法
        森本 智紀; 山本 健人; 前川 久継; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 三好 弘之; 武藤 誠; 小濱 和貴
        日本外科学会定期学術集会抄録集, Apr. 2023
      • 胃癌切除標本由来の胃癌細胞三次元培養法(Spheroid培養法)と臨床応用への有用性
        森本 智紀; 三好 弘之; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 小濱 和貴; 武藤 誠; 坂井 義治
        日本消化器外科学会総会, Dec. 2020
      • Novel and efficient method for culturing patient-derived gastric cancer stem cells.
        Tomonori Morimoto; Yukitoshi Takemura; Takemitsu Miura; Takehito Yamamoto; Fumihiko Kakizaki; Hideo An; Hisatsugu Maekawa; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; Yoshiaki Yuba; Hiroaki Terajima; Kazutaka Obama; Makoto Mark Taketo; Hiroyuki Miyoshi
        Cancer science, 20 May 2023
      • Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors.
        Hiroyuki Matsubara; Hiroyuki Miyoshi; Fumihiko Kakizaki; Tomonori Morimoto; Kenji Kawada; Takehito Yamamoto; Kazutaka Obama; Yoshiharu Sakai; Makoto Mark Taketo
        Molecular cancer therapeutics, 10 Feb. 2023
      • Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells
        Gen Nishikawa; kenji kawada; Keita Hanada; Hisatsugu Maekawa; Yoshiro Itatani; Makoto Taketo; Kazutaka Obama
        Cells, 18 Oct. 2022
      • Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
        Keita Hanada; Kenji Kawada; Gen Nishikawa; Kosuke Toda; Hisatsugu Maekawa; Yasuyo Nishikawa; Hideyuki Masui; Wataru Hirata; Michio Okamoto; Yoshiyuki Kiyasu; Shusaku Honma; Ryotaro Ogawa; Rei Mizuno; Yoshiro Itatani; Hiroyuki Miyoshi; Takehiko Sasazuki; Senji Shirasawa; M Mark Taketo; Kazutaka Obama; Yoshiharu Sakai
        Cancer letters, 01 Dec. 2021
      • The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells
        Takeshi Ito; Yohei Kawai; Yutaka Yasui; Shoichi Iriguchi; Atsutaka Minagawa; Tomoko Ishii; Hiroyuki Miyoshi; M. Mark Taketo; Kenji Kawada; Kazutaka Obama; Yoshiharu Sakai; Shin Kaneko
        Communications Biology, Dec. 2021
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      • EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase
        Takeshi Ouchi; Sohshi Morimura; Lukas E. Dow; Hiroyuki Miyoshi; Mark C. Udey
        Cells, 28 Jan. 2021
      • Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy.
        Takehito Yamamoto; Hiroyuki Miyoshi; Fumihiko Kakizaki; Hisatsugu Maekawa; Tadayoshi Yamaura; Tomonori Morimoto; Toshiro Katayama; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Cancers, 22 Jul. 2020, Peer-reviewed
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      • Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        Nature, Jan. 2020, Peer-reviewed
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      • MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer.
        Aya Nishiuchi; Shigeo Hisamori; Masazumi Sakaguchi; Keita Fukuyama; Nobuaki Hoshino; Yoshiro Itatani; Shusaku Honma; Hisatsugu Maekawa; Tatsuto Nishigori; Shigeru Tsunoda; Kazutaka Obama; Hiroyuki Miyoshi; Yohei Shimono; M Mark Taketo; Yoshiharu Sakai
        Cancers, 27 Nov. 2019, Peer-reviewed
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      • Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.
        Norihiro Goto; Akihisa Fukuda; Yuichi Yamaga; Takaaki Yoshikawa; Takahisa Maruno; Hisatsugu Maekawa; Susumu Inamoto; Kenji Kawada; Yoshiharu Sakai; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        Proceedings of the National Academy of Sciences of the United States of America, 25 Jun. 2019, Peer-reviewed
      • 大腸癌診療におけるprecision medicine 患者組織由来の癌幹細胞Spheroidから抽出した高純度DNA検体による大腸癌マイクロサテライト不安性検査
        山浦 忠能; 河田 健二; 前川 久継; 森本 智紀; 山本 健人; 三好 弘之; 坂井 義治; 武藤 誠
        日本外科学会定期学術集会抄録集, Apr. 2019, Peer-reviewed
      • Arid1a is essential for intestinal stem cells through Sox9 regulation.
        Yukiko Hiramatsu; Akihisa Fukuda; Satoshi Ogawa; Norihiro Goto; Kozo Ikuta; Motoyuki Tsuda; Yoshihide Matsumoto; Yoshito Kimura; Takuto Yoshioka; Yutaka Takada; Takahisa Maruno; Yuta Hanyu; Tatsuaki Tsuruyama; Zhong Wang; Haruhiko Akiyama; Shigeo Takaishi; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        Proceedings of the National Academy of Sciences of the United States of America, 29 Jan. 2019, Peer-reviewed
      • Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.
        Tadayoshi Yamaura; Hiroyuki Miyoshi; Hisatsugu Maekawa; Tomonori Morimoto; Takehito Yamamoto; Fumihiko Kakizaki; Koichiro Higasa; Kenji Kawada; Fumihiko Matsuda; Yoshiharu Sakai; M Mark Taketo
        Oncotarget, 25 Dec. 2018, Peer-reviewed
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      • A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells.
        Hisatsugu Maekawa; Hiroyuki Miyoshi; Tadayoshi Yamaura; Yoshiro Itatani; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Molecular cancer therapeutics, Oct. 2018, Peer-reviewed
      • 患者由来大腸癌細胞のスフェロイド培養およびそのマウスモデルを用いた抗癌剤感受性試験(A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells)
        前川 久継; 三好 弘之; 板谷 喜朗; 河田 健二; 坂井 義治; 武藤 誠
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • 高効率で低コストの患者由来大腸がんスフェロイド培養法(An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids)
        三好 弘之; 前川 久継; 柿崎 文彦; 河田 健二; 坂井 義治; 武藤 誠
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies
        Aoyama N; Miyoshi H; Miyachi H; Sonoshita M; Okabe M; Taketo MM
        Genes to Cells, May 2018, Peer-reviewed
      • An improved method for culturing patient-derived colorectal cancer spheroids.
        Hiroyuki Miyoshi; Hisatsugu Maekawa; Fumihiko Kakizaki; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Oncotarget, 24 Apr. 2018, Peer-reviewed
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      • Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine
        Norihiro Goto; Taro Ueo; Akihisa Fukuda; Kenji Kawada; Yoshiharu Sakai; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        CANCER RESEARCH, Jul. 2017, Peer-reviewed
      • Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium
        Hiroyuki Miyoshi; Kelli L. VanDussen; Nicole P. Malvin; Stacy H. Ryu; Yi Wang; Naomi M. Sonnek; Chin-Wen Lai; Thaddeus S. Stappenbeck
        EMBO JOURNAL, Jan. 2017, Peer-reviewed
      • Wnt-expressing cells in the intestines: guides for tissue remodeling
        Hiroyuki Miyoshi
        JOURNAL OF BIOCHEMISTRY, Jan. 2017, Peer-reviewed
      • Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2
        Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; M. Mark Taketo
        CANCER SCIENCE, Nov. 2016, Peer-reviewed
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      • Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis
        Yoshihisa Okuchi; Masamichi Imajo; Rei Mizuno; Yuji Kamioka; Hiroyuki Miyoshi; Makoto Mark Taketo; Satoshi Nagayama; Yoshiharu Sakai; Michiyuki Matsuda
        PLOS ONE, Sep. 2016, Peer-reviewed
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      • Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development
        Kazuhiko Uchiyama; Toshio Sakiyama; Takumu Hasebe; Mark W. Musch; Hiroyuki Miyoshi; Yasushi Nakagawa; Tong-Chuan He; Lev Lichtenstein; Yuji Naito; Yoshito Itoh; Toshikazu Yoshikawa; Bana Jabri; Thaddeus Stappenbeck; Eugene B. Chang
        SCIENTIFIC REPORTS, Aug. 2016, Peer-reviewed
      • Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
        Kelli L. VanDussen; Jeffrey M. Marinshaw; Nurmohammad Shaikh; Hiroyuki Miyoshi; Clara Moon; Phillip I. Tarr; Matthew A. Ciorba; Thaddeus S. Stappenbeck
        GUT, Jun. 2015, Peer-reviewed
      • Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair
        Lulu Sun; Hiroyuki Miyoshi; Sofia Origanti; Timothy J. Nice; Alexandra C. Barger; Nicholas A. Manieri; Leslie A. Fogel; Anthony R. French; David Piwnica-Worms; Helen Piwnica-Worms; Herbert W. Virgin; Deborah J. Lenschow; Thaddeus S. Stappenbeck
        CELL HOST & MICROBE, Jan. 2015, Peer-reviewed
      • Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis
        Thomas J. Hannan; Pacita L. Roberts; Terrence E. Riehl; Sjoerd van der Post; Jana M. Binkley; Drew J. Schwartz; Hiroyuki Miyoshi; Matthias Mack; Reto A. Schwendener; Thomas M. Hooton; Thaddeus S. Stappenbeck; Gunnar C. Hansson; William F. Stenson; Marco Colonna; Ann E. Stapleton; Scott J. Hultgren
        EBIOMEDICINE, Nov. 2014, Peer-reviewed
      • Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis
        C. Moon; K. L. VanDussen; H. Miyoshi; T. S. Stappenbeck
        MUCOSAL IMMUNOLOGY, Jul. 2014, Peer-reviewed
      • Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
        Khushbu K. Patel; Hiroyuki Miyoshi; Wandy L. Beatty; Richard D. Head; Nicole P. Malvin; Ken Cadwell; Jun-Lin Guan; Tatsuya Saitoh; Shizuo Akira; Per O. Seglen; Mary C. Dinauer; Herbert W. Virgin; Thaddeus S. Stappenbeck
        EMBO Journal, 11 Dec. 2013, Peer-reviewed
      • In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture
        Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        NATURE PROTOCOLS, Dec. 2013, Peer-reviewed
      • The Young and the Wnt-less: Transplantable Fetal Intestinal Spheroids without Wnts
        Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        CELL STEM CELL, Dec. 2013, Peer-reviewed
      • Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-beta
        Miyoshi, H.; Stappenbeck, T. S.
        Cell Cycle, Feb. 2013, Peer-reviewed
      • A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype
        Aly, H.; Rohatgi, N.; Marshall, C. A.; Grossenheider, T. C.; Miyoshi, H.; Stappenbeck, T. S.; Matkovich, S. J.; McDaniel, M. L.
        PLoS One, 2013, Peer-reviewed
      • Wnt5a Potentiates TGF-beta Signaling to Promote Colonic Crypt Regeneration After Tissue Injury
        Hiroyuki Miyoshi; Rieko Ajima; Christine T. Luo; Terry P. Yamaguchi; Thaddeus S. Stappenbeck
        SCIENCE, Oct. 2012, Peer-reviewed
      • Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice
        Nicholas A. Manieri; Monica R. Drylewicz; Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        GASTROENTEROLOGY, Jul. 2012, Peer-reviewed
      • Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
        Satoshi Yamazaki; Hideo Ema; Goran Karlsson; Tomoyuki Yamaguchi; Hiroyuki Miyoshi; Seiji Shioda; Makoto M. Taketo; Stefan Karlsson; Atsushi Iwama; Hiromitsu Nakauchi
        CELL, Nov. 2011, Peer-reviewed
      • LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain
        Atsuko Deguchi; Hiroyuki Miyoshi; Yasushi Kojima; Katsuya Okawa; Masahiro Aoki; Makoto M. Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2010, Peer-reviewed
      • CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium
        Fumihiko Kakizaki; Koji Aoki; Hiroyuki Miyoshi; Nancy Carrasco; Masahiro Aoki; Makoto M. Taketo
        GASTROENTEROLOGY, Feb. 2010, Peer-reviewed
      • Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice
        Hiroyuki Miyoshi; Atsuko Deguchi; Masayuki Nakau; Yasushi Kojima; Akira Mori; Masanobu Oshima; Masahiro Aoki; Makoto Mark Taketo
        CANCER SCIENCE, Nov. 2009, Peer-reviewed
      • The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair
        Thaddeus S. Stappenbeck; Hiroyuki Miyoshi
        SCIENCE, Jun. 2009, Peer-reviewed
      • Efficient colonic mucosal wound repair requires Trem2 signaling
        Hiroshi Seno; Hiroyuki Miyoshi; Sarah L. Brown; Michael J. Geske; Marco Colonna; Thaddeus S. Stappenbeck
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2009, Peer-reviewed
      • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
        Ken Cadwell; John Y. Liu; Sarah L. Brown; Hiroyuki Miyoshi; Joy Loh; Jochen K. Lennerz; Chieko Kishi; Wumesh Kc; Javier A. Carrero; Steven Hunt; Christian D. Stone; Elizabeth M. Brunt; Ramnik J. Xavier; Barry P. Sleckman; Ellen Li; Noboru Mizushima; Thaddeus S. Stappenbeck; Herbert W. Virgin
        NATURE, Nov. 2008, Peer-reviewed
      • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action
        Nigel Turner; Jing-Ya Li; Alison Gosby; Sabrina W. C. To; Zhe Cheng; Hiroyuki Miyoshi; Makoto M. Taketo; Gregory J. Cooney; Edward W. Kraegen; David E. James; Li-Hong Hu; Jia Li; Ji-Ming Ye
        DIABETES, May 2008, Peer-reviewed
      • Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
        Yasushi Kojima; Hiroyuki Miyoshi; Hans C. Clevers; Masanobu Oshima; Masahiro Aoki; Makoto M. Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2007, Peer-reviewed
      • Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells
        K. Aoki; M. Aoki; M. Sugai; N. Harada; H. Miyoshi; T. Tsukamoto; T. Mizoshita; M. Tatematsu; H. Seno; T. Chiba; M. Oshima; C-L Hsieh; M. M. Taketo
        ONCOGENE, May 2007, Peer-reviewed
      • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
        Takanori Kitamura; Kohei Kometani; Hiroki Hashida; Akihiro Matsunaga; Hiroyuki Miyoshi; Hisahiro Hosogi; Masahiro Aoki; Masanobu Oshima; Masakazu Hattori; Arimichi Takabayashi; Nagahiro Minato; Makoto M. Taketo
        NATURE GENETICS, Apr. 2007, Peer-reviewed
      • Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
        Takaharu Maruyama; Kenichi Tanaka; Jun Suzuki; Hiroyuki Miyoshi; Naomoto Harada; Takao Nakamura; Yasuhisa Miyamoto; Akio Kanatani; Yoshitaka Tamai
        JOURNAL OF ENDOCRINOLOGY, Oct. 2006, Peer-reviewed
      • Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1(+/-)p53(-/-) compound mutant mice
        H Takeda; H Miyoshi; Y Kojima; M Oshima; MM Taketo
        ONCOGENE, Mar. 2006, Peer-reviewed
      • A targeted mutation of Nkd1 impairs mouse spermatogenesis
        Q Li; T Ishikawa; H Miyoshi; M Oshima; MM Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2005, Peer-reviewed
      • Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
        H Takeda; H Miyoshi; Y Tamai; M Oshima; MM Taketo
        BRITISH JOURNAL OF CANCER, Feb. 2004, Peer-reviewed
      • Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice
        S Okano; A Asano; Y Kon; H Miyoshi; T Watanabe
        BIOCHEMICAL GENETICS, Oct. 2002, Peer-reviewed
      • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
        M Nakau; H Miyoshi; MF Seldin; M Imamura; M Oshima; MM Taketo
        CANCER RESEARCH, Aug. 2002, Peer-reviewed
      • Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin
        N Harada; H Miyoshi; N Murai; H Oshima; Y Tamai; M Oshima; MM Taketo
        CANCER RESEARCH, Apr. 2002, Peer-reviewed
      • Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
        H Miyoshi; M Nakau; T Ishikawa; MF Seldin; M Oshima; MM Taketo
        CANCER RESEARCH, Apr. 2002, Peer-reviewed
      • Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
        K Takaku; H Miyoshi; A Matsunaga; M Oshima; N Sasaki; MM Taketo
        CANCER RESEARCH, Dec. 1999, Peer-reviewed
      • Jumbled spine and ribs (Jsr): a new mutation on mouse Chromosome 5
        H Miyoshi; Y Kon; KW Seo; HK Jin; A Hasegawa; T Watanabe
        MAMMALIAN GENOME, Mar. 1999, Peer-reviewed
      • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
        K Takaku; M Oshima; H Miyoshi; M Matsui; MF Seldin; MM Taketo
        CELL, Mar. 1998, Peer-reviewed
      • Chromosomal mapping and developmental study of tattered-Hokkaido (Td(ho))
        KW Seo; H Miyoshi; Y Kon; T Watanabe
        MAMMALIAN GENOME, Aug. 1997, Peer-reviewed

      Misc.

      • An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids
        Hiroyuki Miyoshi; Hisatsugu Maekawa; Fumihiko Kakizaki; Kenji Kawada; Yoshiharu Sakai; Makoto M. Taketo
        CANCER SCIENCE, Dec. 2018
      • Expression of metastasis suppressor gene AES driven by YY element in a CpG island promoter and transcription factor YY2
        Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; Makoto M. Taketo
        CANCER SCIENCE, Jan. 2018
      • Intestinal adenocarcinomas in compound mutant mice of both Dpc4(Samd4)and Apc Genes
        TAKAKU Kazuaki; OSHIMA Masanobu; MIYOSHI Hiroyuki; MATSUI Minoru; SELDIN Michael F.; TAKETO Makoto M.
        日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998
      • Lkb1欠損マウスに発生するHCCとその分子機序
        中右 雅之; 三好 弘之; 森 章; 小野寺 久; 大島 正伸; 武藤 誠; 今村 正之
        日本外科学会雑誌, 30 Apr. 2003
      • Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Akaki Kotaro; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Tomonori Hirano; Yasuhide Takeuchi; Hiroyuki Miyoshi; Yoshiharu Sakai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        CANCER RESEARCH, Aug. 2020
      • Prostaglandin E2 Promotes Intestinal Repair Through an Adaptive Cellular Response of the Epithelium
        Hiroyuki Miyoshi; Kelli VanDussen; Nicole Malvin; Stacy Ryu; Yi Wang; Naomi Sonnek; Chin-Wen Lai; Thaddeus Stappenbeck
        INFLAMMATORY BOWEL DISEASES, Feb. 2017
      • Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis
        Thomas J. Hannan; Pacita L. Roberts; Terrence E. Riehl; Sjoerd van der Post; Jana M. Binkley; Drew J. Schwartz; Hiroyuki Miyoshi; Matthias Mack; Reto A. Schwendener; Thomas M. Hooton; Thaddeus S. Stappenbeck; Gunnar C. Hansson; William F. Stenson; Marco Colonna; Ann E. Stapleton; Scott J. Hultgren
        JOURNAL OF WOMENS HEALTH, Oct. 2014
      • Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract
        Kelli L. VanDussen; Jeffrey M. Marinshaw; Hiroyuki Miyoshi; Matthew A. Ciorba; Thaddeus S. Stappenbeck
        GASTROENTEROLOGY, May 2013

      External funds: Kakenhi

      • Investigation of epigenetic modifications that specify tissue identity of adult epithelial cells
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49030:Experimental pathology-related
        Kyoto University
        Hiroyuki Miyoshi
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        エピジェネティクス;スフェロイド培養;組織幹細胞;癌幹細胞;スフェロイド;がん幹細胞;Wnt
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02639/
      • Studies on digestive cancer metastasis using mouse models
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Makoto TAKETO
        From 01 Apr. 2007, To 31 Mar. 2009, Project Closed
        分子腫瘍学;癌;転移;病理学;細胞・組織;Notch;ケモカイン;マイクロアレイ;CXCR3
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19209010/
      • The mechanisms of preneoplastic nodule formation in the liver by loss of LKB1
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Hiroyuki MIYOSHI
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        肝臓癌;LKB1;キナーゼ;マウス;マイクロアレイ, Hepatocellular carcinoma;LKB1;Kinase;Mouse;Microarray
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590368/
      • Epitehial-stromal interactions and molecularly targeted therapy
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Makoto TAKETO
        From 01 Apr. 2005, To 31 Mar. 2010, Project Closed
        癌;炎症;血管新生;シグナル伝達;マイクロアレイ;遺伝子改変マウス;mTORC1;MMP7;Lkb1;病理学;トランスジェニックマウス;Apc;COX-2;間質細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016032/
      • 消化器癌の転移機構とその治療の研究
        Grant-in-Aid for Creative Scientific Research
        Kyoto University
        武藤 誠
        From 01 Apr. 2002, To 31 Mar. 2007, Project Closed
        転移;浸潤;同所移植;マイクロアレイ;ケモカイン;CXCR3;CCR1;CCL9;トランスジェニックマウス;COX-2;CDX2;Wnt;LKB1;染色体不安定性;マクロファージ;プロテオミクス;Cdx2;mTOR;B16F10;リンパ管新生;LYVE-1;mPGES
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14GS0316/
      • Epithelium-stroma interactions in carcinogenesis
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        KYOTO UNIVERSITY
        Makoto Mark TAKETO
        From 01 Apr. 2000, To 31 Mar. 2005, Project Closed
        APC;COX-2;プロスタグランジン;間質細胞;トランスジェニックマウス;癌;病理学;LKB1;Apc;マイクロアレイ;Lkb1;Fhit;線維芽細胞;TGF-βシグナル;大腸癌;肝癌;ノックアウトマウス;血管新生;Smad2;β-catenin;ポリープ;cPLA2;PGE_2;EP2, APC;COX-2;Prostaglandin;Stromal cells;Transgenic mouse;Cancer;Pathology;LKB 1
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12219203/
      • 大腸上皮の分化指標に基づく大腸がん予後予測新規因子の解明
        Grant-in-Aid for Scientific Research (C)
        Basic Section 50010:Tumor biology-related
        Kyoto University
        三好 弘之
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        大腸がん;スフェロイド;幹細胞;分化;マーカー遺伝子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07187/

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