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三好 弘之

ミヨシ ヒロユキ

医学部附属病院 先端医療研究開発機構 准教授

三好 弘之
list
    Last Updated :2022/08/08

    基本情報

    学位

    • 博士(医学)(京都大学)

    出身学校・専攻等

    • 北海道大学, 獣医学部獣医学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2022/08/08

      研究

      研究分野

      • ライフサイエンス, 腫瘍生物学

      論文

      • iPSC-based CAR-T therapy targeting for GPC3
        Ueda Tatsuki; Irigchi Shoich; Kawai Youhei; Minagawa Atsutaka; Miyoshi Hiroyuki; Terakura Seitaro; Uemura Yasushi; Woltjen Knut; Kodama Yuzo; Tamada Koji; Nakatsura Tetsuya; Seno Hiroshi; Kaneko Shin
        CANCER SCIENCE, 2018年01月, 査読有り
      • Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
        Keita Hanada; Kenji Kawada; Gen Nishikawa; Kosuke Toda; Hisatsugu Maekawa; Yasuyo Nishikawa; Hideyuki Masui; Wataru Hirata; Michio Okamoto; Yoshiyuki Kiyasu; Shusaku Honma; Ryotaro Ogawa; Rei Mizuno; Yoshiro Itatani; Hiroyuki Miyoshi; Takehiko Sasazuki; Senji Shirasawa; M Mark Taketo; Kazutaka Obama; Yoshiharu Sakai
        Cancer letters, 2021年12月01日
      • The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells
        Takeshi Ito; Yohei Kawai; Yutaka Yasui; Shoichi Iriguchi; Atsutaka Minagawa; Tomoko Ishii; Hiroyuki Miyoshi; M. Mark Taketo; Kenji Kawada; Kazutaka Obama; Yoshiharu Sakai; Shin Kaneko
        Communications Biology, 2021年12月
      • EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase
        Takeshi Ouchi; Sohshi Morimura; Lukas E. Dow; Hiroyuki Miyoshi; Mark C. Udey
        Cells, 2021年01月28日
      • 胃癌切除標本由来の胃癌細胞三次元培養法(Spheroid培養法)と臨床応用への有用性
        森本 智紀; 三好 弘之; 錦織 達人; 久森 重夫; 角田 茂; 河田 健二; 小濱 和貴; 武藤 誠; 坂井 義治
        日本消化器外科学会総会, 2020年12月
      • Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy.
        Takehito Yamamoto; Hiroyuki Miyoshi; Fumihiko Kakizaki; Hisatsugu Maekawa; Tadayoshi Yamaura; Tomonori Morimoto; Toshiro Katayama; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Cancers, 2020年07月22日, 査読有り
      • Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        Nature, 2020年01月, 査読有り
      • MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer.
        Aya Nishiuchi; Shigeo Hisamori; Masazumi Sakaguchi; Keita Fukuyama; Nobuaki Hoshino; Yoshiro Itatani; Shusaku Honma; Hisatsugu Maekawa; Tatsuto Nishigori; Shigeru Tsunoda; Kazutaka Obama; Hiroyuki Miyoshi; Yohei Shimono; M Mark Taketo; Yoshiharu Sakai
        Cancers, 2019年11月27日, 査読有り
      • Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.
        Norihiro Goto; Akihisa Fukuda; Yuichi Yamaga; Takaaki Yoshikawa; Takahisa Maruno; Hisatsugu Maekawa; Susumu Inamoto; Kenji Kawada; Yoshiharu Sakai; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        Proceedings of the National Academy of Sciences of the United States of America, 2019年06月25日, 査読有り
      • 大腸癌診療におけるprecision medicine 患者組織由来の癌幹細胞Spheroidから抽出した高純度DNA検体による大腸癌マイクロサテライト不安性検査
        山浦 忠能; 河田 健二; 前川 久継; 森本 智紀; 山本 健人; 三好 弘之; 坂井 義治; 武藤 誠
        日本外科学会定期学術集会抄録集, 2019年04月, 査読有り
      • Arid1a is essential for intestinal stem cells through Sox9 regulation.
        Yukiko Hiramatsu; Akihisa Fukuda; Satoshi Ogawa; Norihiro Goto; Kozo Ikuta; Motoyuki Tsuda; Yoshihide Matsumoto; Yoshito Kimura; Takuto Yoshioka; Yutaka Takada; Takahisa Maruno; Yuta Hanyu; Tatsuaki Tsuruyama; Zhong Wang; Haruhiko Akiyama; Shigeo Takaishi; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        Proceedings of the National Academy of Sciences of the United States of America, 2019年01月29日, 査読有り
      • Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.
        Tadayoshi Yamaura; Hiroyuki Miyoshi; Hisatsugu Maekawa; Tomonori Morimoto; Takehito Yamamoto; Fumihiko Kakizaki; Koichiro Higasa; Kenji Kawada; Fumihiko Matsuda; Yoshiharu Sakai; M Mark Taketo
        Oncotarget, 2018年12月25日, 査読有り
      • A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells.
        Hisatsugu Maekawa; Hiroyuki Miyoshi; Tadayoshi Yamaura; Yoshiro Itatani; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Molecular cancer therapeutics, 2018年10月, 査読有り
      • 患者由来大腸癌細胞のスフェロイド培養およびそのマウスモデルを用いた抗癌剤感受性試験(A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells)
        前川 久継; 三好 弘之; 板谷 喜朗; 河田 健二; 坂井 義治; 武藤 誠
        日本癌学会総会記事, 2018年09月, 査読有り
      • 高効率で低コストの患者由来大腸がんスフェロイド培養法(An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids)
        三好 弘之; 前川 久継; 柿崎 文彦; 河田 健二; 坂井 義治; 武藤 誠
        日本癌学会総会記事, 2018年09月, 査読有り
      • Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies
        Aoyama N; Miyoshi H; Miyachi H; Sonoshita M; Okabe M; Taketo MM
        Genes to Cells, 2018年05月, 査読有り
      • An improved method for culturing patient-derived colorectal cancer spheroids.
        Hiroyuki Miyoshi; Hisatsugu Maekawa; Fumihiko Kakizaki; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; M Mark Taketo
        Oncotarget, 2018年04月24日, 査読有り
      • Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine
        Norihiro Goto; Taro Ueo; Akihisa Fukuda; Kenji Kawada; Yoshiharu Sakai; Hiroyuki Miyoshi; Makoto Mark Taketo; Tsutomu Chiba; Hiroshi Seno
        CANCER RESEARCH, 2017年07月, 査読有り
      • Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.
        Miyoshi H; VanDussen KL; Malvin NP; Ryu SH; Wang Y; Sonnek NM; Lai CW; Stappenbeck TS
        The EMBO journal, 2017年01月, 査読有り
      • Wnt-expressing cells in the intestines: guides for tissue remodeling
        Hiroyuki Miyoshi
        JOURNAL OF BIOCHEMISTRY, 2017年01月, 査読有り
      • Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2
        Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; M. Mark Taketo
        CANCER SCIENCE, 2016年11月, 査読有り
      • Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis
        Yoshihisa Okuchi; Masamichi Imajo; Rei Mizuno; Yuji Kamioka; Hiroyuki Miyoshi; Makoto Mark Taketo; Satoshi Nagayama; Yoshiharu Sakai; Michiyuki Matsuda
        PLOS ONE, 2016年09月, 査読有り
      • Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development
        Kazuhiko Uchiyama; Toshio Sakiyama; Takumu Hasebe; Mark W. Musch; Hiroyuki Miyoshi; Yasushi Nakagawa; Tong-Chuan He; Lev Lichtenstein; Yuji Naito; Yoshito Itoh; Toshikazu Yoshikawa; Bana Jabri; Thaddeus Stappenbeck; Eugene B. Chang
        SCIENTIFIC REPORTS, 2016年08月, 査読有り
      • Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
        Kelli L. VanDussen; Jeffrey M. Marinshaw; Nurmohammad Shaikh; Hiroyuki Miyoshi; Clara Moon; Phillip I. Tarr; Matthew A. Ciorba; Thaddeus S. Stappenbeck
        GUT, 2015年06月, 査読有り
      • Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair
        Lulu Sun; Hiroyuki Miyoshi; Sofia Origanti; Timothy J. Nice; Alexandra C. Barger; Nicholas A. Manieri; Leslie A. Fogel; Anthony R. French; David Piwnica-Worms; Helen Piwnica-Worms; Herbert W. Virgin; Deborah J. Lenschow; Thaddeus S. Stappenbeck
        CELL HOST & MICROBE, 2015年01月, 査読有り
      • Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis
        Thomas J. Hannan; Pacita L. Roberts; Terrence E. Riehl; Sjoerd van der Post; Jana M. Binkley; Drew J. Schwartz; Hiroyuki Miyoshi; Matthias Mack; Reto A. Schwendener; Thomas M. Hooton; Thaddeus S. Stappenbeck; Gunnar C. Hansson; William F. Stenson; Marco Colonna; Ann E. Stapleton; Scott J. Hultgren
        EBIOMEDICINE, 2014年11月, 査読有り
      • Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis
        C. Moon; K. L. VanDussen; H. Miyoshi; T. S. Stappenbeck
        MUCOSAL IMMUNOLOGY, 2014年07月, 査読有り
      • Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
        Khushbu K. Patel; Hiroyuki Miyoshi; Wandy L. Beatty; Richard D. Head; Nicole P. Malvin; Ken Cadwell; Jun-Lin Guan; Tatsuya Saitoh; Shizuo Akira; Per O. Seglen; Mary C. Dinauer; Herbert W. Virgin; Thaddeus S. Stappenbeck
        EMBO Journal, 2013年12月11日, 査読有り
      • In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture
        Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        NATURE PROTOCOLS, 2013年12月, 査読有り
      • The Young and the Wnt-less: Transplantable Fetal Intestinal Spheroids without Wnts
        Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        CELL STEM CELL, 2013年12月, 査読有り
      • Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β.
        Miyoshi H; Stappenbeck TS
        Cell cycle (Georgetown, Tex.), 2013年02月, 査読有り
      • A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.
        Aly H; Rohatgi N; Marshall CA; Grossenheider TC; Miyoshi H; Stappenbeck TS; Matkovich SJ; McDaniel ML
        PloS one, 2013年, 査読有り
      • Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.
        Miyoshi H; Ajima R; Luo CT; Yamaguchi TP; Stappenbeck TS
        Science (New York, N.Y.), 2012年10月, 査読有り
      • Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice
        Nicholas A. Manieri; Monica R. Drylewicz; Hiroyuki Miyoshi; Thaddeus S. Stappenbeck
        GASTROENTEROLOGY, 2012年07月, 査読有り
      • Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
        Satoshi Yamazaki; Hideo Ema; Goran Karlsson; Tomoyuki Yamaguchi; Hiroyuki Miyoshi; Seiji Shioda; Makoto M. Taketo; Stefan Karlsson; Atsushi Iwama; Hiromitsu Nakauchi
        CELL, 2011年11月, 査読有り
      • LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain
        Atsuko Deguchi; Hiroyuki Miyoshi; Yasushi Kojima; Katsuya Okawa; Masahiro Aoki; Makoto M. Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2010年06月, 査読有り
      • CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium
        Fumihiko Kakizaki; Koji Aoki; Hiroyuki Miyoshi; Nancy Carrasco; Masahiro Aoki; Makoto M. Taketo
        GASTROENTEROLOGY, 2010年02月, 査読有り
      • Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice
        Hiroyuki Miyoshi; Atsuko Deguchi; Masayuki Nakau; Yasushi Kojima; Akira Mori; Masanobu Oshima; Masahiro Aoki; Makoto Mark Taketo
        CANCER SCIENCE, 2009年11月, 査読有り
      • The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair
        Thaddeus S. Stappenbeck; Hiroyuki Miyoshi
        SCIENCE, 2009年06月, 査読有り
      • Efficient colonic mucosal wound repair requires Trem2 signaling
        Hiroshi Seno; Hiroyuki Miyoshi; Sarah L. Brown; Michael J. Geske; Marco Colonna; Thaddeus S. Stappenbeck
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009年01月, 査読有り
      • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
        Ken Cadwell; John Y. Liu; Sarah L. Brown; Hiroyuki Miyoshi; Joy Loh; Jochen K. Lennerz; Chieko Kishi; Wumesh Kc; Javier A. Carrero; Steven Hunt; Christian D. Stone; Elizabeth M. Brunt; Ramnik J. Xavier; Barry P. Sleckman; Ellen Li; Noboru Mizushima; Thaddeus S. Stappenbeck; Herbert W. Virgin
        NATURE, 2008年11月, 査読有り
      • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action
        Nigel Turner; Jing-Ya Li; Alison Gosby; Sabrina W. C. To; Zhe Cheng; Hiroyuki Miyoshi; Makoto M. Taketo; Gregory J. Cooney; Edward W. Kraegen; David E. James; Li-Hong Hu; Jia Li; Ji-Ming Ye
        DIABETES, 2008年05月, 査読有り
      • Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
        Yasushi Kojima; Hiroyuki Miyoshi; Hans C. Clevers; Masanobu Oshima; Masahiro Aoki; Makoto M. Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2007年08月, 査読有り
      • Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells
        K. Aoki; M. Aoki; M. Sugai; N. Harada; H. Miyoshi; T. Tsukamoto; T. Mizoshita; M. Tatematsu; H. Seno; T. Chiba; M. Oshima; C-L Hsieh; M. M. Taketo
        ONCOGENE, 2007年05月, 査読有り
      • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
        Takanori Kitamura; Kohei Kometani; Hiroki Hashida; Akihiro Matsunaga; Hiroyuki Miyoshi; Hisahiro Hosogi; Masahiro Aoki; Masanobu Oshima; Masakazu Hattori; Arimichi Takabayashi; Nagahiro Minato; Makoto M. Taketo
        NATURE GENETICS, 2007年04月, 査読有り
      • Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
        Takaharu Maruyama; Kenichi Tanaka; Jun Suzuki; Hiroyuki Miyoshi; Naomoto Harada; Takao Nakamura; Yasuhisa Miyamoto; Akio Kanatani; Yoshitaka Tamai
        JOURNAL OF ENDOCRINOLOGY, 2006年10月, 査読有り
      • Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1(+/-)p53(-/-) compound mutant mice
        H Takeda; H Miyoshi; Y Kojima; M Oshima; MM Taketo
        ONCOGENE, 2006年03月, 査読有り
      • A targeted mutation of Nkd1 impairs mouse spermatogenesis
        Q Li; T Ishikawa; H Miyoshi; M Oshima; MM Taketo
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2005年01月, 査読有り
      • Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
        H Takeda; H Miyoshi; Y Tamai; M Oshima; MM Taketo
        BRITISH JOURNAL OF CANCER, 2004年02月, 査読有り
      • Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice
        S Okano; A Asano; Y Kon; H Miyoshi; T Watanabe
        BIOCHEMICAL GENETICS, 2002年10月, 査読有り
      • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
        M Nakau; H Miyoshi; MF Seldin; M Imamura; M Oshima; MM Taketo
        CANCER RESEARCH, 2002年08月, 査読有り
      • Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin
        N Harada; H Miyoshi; N Murai; H Oshima; Y Tamai; M Oshima; MM Taketo
        CANCER RESEARCH, 2002年04月, 査読有り
      • Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
        H Miyoshi; M Nakau; T Ishikawa; MF Seldin; M Oshima; MM Taketo
        CANCER RESEARCH, 2002年04月, 査読有り
      • Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
        K Takaku; H Miyoshi; A Matsunaga; M Oshima; N Sasaki; MM Taketo
        CANCER RESEARCH, 1999年12月, 査読有り
      • Jumbled spine and ribs (Jsr): a new mutation on mouse Chromosome 5
        H Miyoshi; Y Kon; KW Seo; HK Jin; A Hasegawa; T Watanabe
        MAMMALIAN GENOME, 1999年03月, 査読有り
      • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
        K Takaku; M Oshima; H Miyoshi; M Matsui; MF Seldin; MM Taketo
        CELL, 1998年03月, 査読有り
      • Chromosomal mapping and developmental study of tattered-Hokkaido (Td(ho))
        KW Seo; H Miyoshi; Y Kon; T Watanabe
        MAMMALIAN GENOME, 1997年08月, 査読有り

      MISC

      • Smad4/Apcの複合変異ノックアウトと大腸癌
        高久 和明; 大島 正伸; 三好 弘之; 松井 稔; SELDIN Michael F.; 武藤 誠
        日本分子生物学会年会プログラム・講演要旨集, 1998年12月01日
      • Lkb1欠損マウスに発生するHCCとその分子機序
        中右 雅之; 三好 弘之; 森 章; 小野寺 久; 大島 正伸; 武藤 誠; 今村 正之
        日本外科学会雑誌, 2003年04月30日
      • Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Akaki Kotaro; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Tomonori Hirano; Yasuhide Takeuchi; Hiroyuki Miyoshi; Yoshiharu Sakai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        CANCER RESEARCH, 2020年08月
      • Prostaglandin E2 Promotes Intestinal Repair Through an Adaptive Cellular Response of the Epithelium
        Hiroyuki Miyoshi; Kelli VanDussen; Nicole Malvin; Stacy Ryu; Yi Wang; Naomi Sonnek; Chin-Wen Lai; Thaddeus Stappenbeck
        INFLAMMATORY BOWEL DISEASES, 2017年02月
      • Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis
        Thomas J. Hannan; Pacita L. Roberts; Terrence E. Riehl; Sjoerd van der Post; Jana M. Binkley; Drew J. Schwartz; Hiroyuki Miyoshi; Matthias Mack; Reto A. Schwendener; Thomas M. Hooton; Thaddeus S. Stappenbeck; Gunnar C. Hansson; William F. Stenson; Marco Colonna; Ann E. Stapleton; Scott J. Hultgren
        JOURNAL OF WOMENS HEALTH, 2014年10月
      • Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract
        Kelli L. VanDussen; Jeffrey M. Marinshaw; Hiroyuki Miyoshi; Matthew A. Ciorba; Thaddeus S. Stappenbeck
        GASTROENTEROLOGY, 2013年05月

      外部資金:科学研究費補助金

      • 成体上皮細胞の組織アイデンティティを特定するエピジェネティック修飾の解明
        基盤研究(B)
        小区分49030:実験病理学関連
        京都大学
        三好 弘之
        自 2018年04月01日, 至 2021年03月31日, 完了
        エピジェネティクス;スフェロイド培養;組織幹細胞;癌幹細胞;スフェロイド;がん幹細胞;Wnt
      • マウスモデルを用いた消化器癌転移の研究
        基盤研究(A)
        京都大学
        武藤 誠
        完了
        分子腫瘍学;癌;転移;病理学;細胞・組織;Notch;ケモカイン;マイクロアレイ;CXCR3
      • LKB1キナーゼ欠失による肝前癌病変形成メカニズムの解析
        基盤研究(C)
        京都大学
        三好 弘之
        完了
        肝臓癌;LKB1;キナーゼ;マウス;マイクロアレイ, Hepatocellular carcinoma;LKB1;Kinase;Mouse;Microarray
      • 上皮-間質相互作用の解析と分子標的治療
        特定領域研究
        生物系
        京都大学
        武藤 誠
        完了
        癌;炎症;血管新生;シグナル伝達;マイクロアレイ;遺伝子改変マウス;mTORC1;MMP7;Lkb1;病理学;トランスジェニックマウス;Apc;COX-2;間質細胞
      • 消化器癌の転移機構とその治療の研究
        学術創成研究費
        京都大学
        武藤 誠
        完了
        転移;浸潤;同所移植;マイクロアレイ;ケモカイン;CXCR3;CCR1;CCL9;トランスジェニックマウス;COX-2;CDX2;Wnt;LKB1;染色体不安定性;マクロファージ;プロテオミクス;Cdx2;mTOR;B16F10;リンパ管新生;LYVE-1;mPGES
      • 発癌機構における上皮と間質の相互作用の研究
        特定領域研究
        生物系
        京都大学
        武藤 誠
        完了
        APC;COX-2;プロスタグランジン;間質細胞;トランスジェニックマウス;癌;病理学;LKB1;Apc;マイクロアレイ;Lkb1;Fhit;線維芽細胞;TGF-βシグナル;大腸癌;肝癌;ノックアウトマウス;血管新生;Smad2;β-catenin;ポリープ;cPLA2;PGE_2;EP2, APC;COX-2;Prostaglandin;Stromal cells;Transgenic mouse;Cancer;Pathology;LKB 1
      • 大腸上皮の分化指標に基づく大腸がん予後予測新規因子の解明
        基盤研究(C)
        小区分50010:腫瘍生物学関連
        京都大学
        三好 弘之
        自 2022年04月01日, 至 2025年03月31日, 交付
        大腸がん;スフェロイド;幹細胞;分化;マーカー遺伝子

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