Kimura, Ikuo(Graduate School of Biostudies, Division of Systemic Life Science) | Activity Database on Education and Research, Kyoto University

Kimura, Ikuo

Graduate School of Biostudies, Division of Systemic Life Science Professor

Last Updated :2023/05/27

Basic Information

Faculty

薬学部

Email Address

Email Address
kimura.ikuo.7xkyoto-u.ac.jp

Academic Degree

修士（薬学）(京都大学)

修士（薬学）(京都大学)

博士（薬学）(京都大学)

Ph.D. in Pharmacy(Kyoto University)

Academic Resume (Graduate Schools)

Kyoto University, Graduate School of Pharmaceutical Sciences, 修了

Kyoto University, Graduate School of Pharmaceutical Sciences, 修了

Academic Resume (Undergraduate School/Majors)

Kyoto University, Faculty of Pharmacy, 卒業

High School

High School
大阪府立茨木高校

Language of Instruction

Japanese

English

Last Updated :2023/05/27

Research

Research Interests

エネルギー代謝

腸内細菌

性ステロイド

脂肪酸

GPCR

Research Areas

Life sciences, Pharmaceuticals - health and biochemistry

Life sciences, Metabolism and endocrinology

Life sciences, Food sciences

Life sciences, Nutrition and health science

Papers

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem
Katoh T, Yamada C, Wallace MD, Yoshida A, Gotoh A, Arai M, Maeshibu T, Kashima T, Hagenbeek A, Ojima MN, Takada H, Sakanaka M, Shimizu H, Nishiyama K, Ashida H, Hirose J, Suarez-Diez M, Nishiyama M, Kimura I, Stubbs KA, Fushinobu S, Katayama T
Nature Chem Biol, 2023, Peer-reviewed

Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
Igarashi M, Iwasa K, Hayakawa T, Tsuduki T, Kimura I, Maruyama K, Yoshikawa K
Front Endocrinol (Lausanne), 2023, Peer-reviewed

Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides.
Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I*
Gut Microbes, 2023, Peer-reviewed, Corresponding author

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
Ohue-Kitano R, Nonaka H, Nishida A, Masujima Y, Takahashi D, Ikeda T, Uwamizu A, Tanaka M, Kohjima M, Igarashi M, Katoh H, Tanaka T, Inoue A, Suganami T, Hase K, Ogawa Y, Aoki J, Kimura I*
JCI Insight, 2023, Peer-reviewed, Corresponding author

Intestinal GPR119 activation by microbiota-derived metabolites impacts feeding behavior and energy metabolism.
Igarashi M, Hayakawa T, Tanabe H, Watanabe K, Nishida A, Kimura I*
Mol Metab, 2023, Peer-reviewed, Corresponding author

Consumption of barley flour increases gut fermentation and improves glucose intolerancevia the short-chain fatty acid receptor GPR43 in obese male mice.
Mio K; Iida-Tanaka N; Yamanaka C; Kimura I; Aoe S
Food Funct, 2022, Peer-reviewed

The impact of low-viscosity soluble dietary fibers on intestinal microenvironment and experimental colitis: A possible preventive application of alpha-cyclodextrin in intestinal inflammation.
Yamanouchi Y; Chudan S; Ishibashi R; Ohue-Kitano R; Nishikawa M; Tabuchi Y; Kimura I; Nagai Y; Ikushiro S; Furusawa Y
Mol Nutr Food Res, 2022, Peer-reviewed

Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases.
Ikeda T; Nishida A; Yamano M; Kimura I*
Pharmacol Ther, 2022, Peer-reviewed, Corresponding author

Impact of habitual chewing on gut motility via microbiota transition.
Yaoita F; Watanabe K; Kimura I; Miyazawa M; Tsuchiya S; Kanzaki M; Tsuchiya M; Tan-No K
Sci Rep, 2022, Peer-reviewed

Cooperative action of gut microbiota-accessible carbohydrates improves host metabolic function.
Tomioka S; Seki N; Sugiura Y; Akiyama M; Uchiyama J; Yamaguchi G; Yakabe K; Ejima R; Hattori K; Kimizuka T; Fujimura Y; Sato H; Gondo M; Ozaki S; Honme Y; Suematsu M; Kimura I; Inohara N; Núñez G; Hase K; Kim YG
Cell Rep, 2022, Peer-reviewed

Phloretin suppresses carbohydrate-induced GLP-1 secretion via inhibiting short chain fatty acid release from gut microbiome.
Ma Y; Lee E; Yoshikawa H; Noda T; Miyamoto J; Kimura I; Hatano R; Miki T
Biochem Biophys Res Commun, 2022, Peer-reviewed

Involvement of gut microbial metabolites derived from diet on host energy homeostasis.
Nishida A; Ando Y; Kimura I; Miyamoto J
Int J Mol Sci, 2022, Peer-reviewed

Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice.
Nonaka H; Ohue-Kitano R; Masujima Y; Igarashi M; Kimura I*
Front Nutr, 2022, Peer-reviewed, Corresponding author

Filamin A forms a complex with EphA2 and regulates EphA2 serine 897 phosphorylation and glioblastoma cell proliferation.
Tamura Y; Nakamizo Y; Watanabe Y; Kimura I; Katoh H
Biochem Biophys Res Commun, 2022, Peer-reviewed

Chemical synthesis and evaluation of exopolysaccharide frangments produced by Leuconostoc mesenteroides strain NTM048.
Inuki S; Tabuchi H; Matsuzaki C; Yonejima Y; Hisa K; Kimura I; Yamamoto K; Ohno H
Chem Pharm Bull (Tokyo), 2022, Peer-reviewed

GPR43 suppresses intestinal tumor growth by modification of the mammalian target of rapamycin complex 1 activity in ApcMin/+ mice.
Kong L; Hoshi N; Sui Y; Yamada Y T; Yoshiba R; Ooi M; Tian Z; Kimura I; Todama Y
Med Princ Pract, 2022, Peer-reviewed

Lecithin inclusion by a-Cyclodextrin activates SREBP2 signaling in the gut and ameliorates postprandial hyperglycemia.
Lee EY; Zhang X; Noda T; Miyamoto J; Kimura I; Tanaka T; Sakurai K; Hatano R; Miki T
Int J Mol Sci, 2021, Peer-reviewed

Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice.
Aoki R; Onuki M; Hattori K; Ito M; Yamada T; Kamikado K; Kim YG; Nakamoto N; Kimura I; Clarke JM; Kanai T; Hase K
Microbiome, 2021, Peer-reviewed

Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice.
Watanabe K, Yamano M, Masujima Y, Ohue-Kitano R, Kimura I*
Biochem Biophys Rep, 2021, Peer-reviewed, Corresponding author

Acetate differentially regulates IgA reactivity to commensal bacteria.
Takeuchi T; Miyauchi E; Kanaya T; Kato T; Nakanishi Y; Watanabe T; Kitami T; Taida T; Sasaki T; Negishi H; Shimamoto S; Matsuyama A; Kimura I; Williams IR; Ohara O; Ohno H
Nature, 2021, Peer-reviewed

Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice.
Nishida A, Miyamoto J, Shimizu H, Kimura I*
Biochem Biophys Res Commun, 2021, Peer-reviewed, Corresponding author

Contribution of uremic dysbiosis to insulin resistance and sarcopenia.
Fukuda T; Bouchi R; Takeuchi T; Amo-Shiinoki K; Kudo A; Tanaka S; Tanabe M; Akashi T; Hirayama K; Odamaki T; Igarashi M; Kimura I; Tanabe K; Tanizawa Y; Yamada T; Ogawa Y
Diabetes Care, 2021, Peer-reviewed

Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.
Hayashima K; Kimura I; Katoh H
Biochem Biophys Res Commun, 2021, Peer-reviewed

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.
Kimura I*, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
Science (New York, N.Y.), 28 Feb. 2020, Peer-reviewed, Lead author, Corresponding author

Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways.
Mikami D; Kobayashi M; Uwada J; Yazawa T; Kamiyama K; Nishimori K; Nishikawa Y; Nishikawa S; Yokoi S; Kimura H; Kimura I; Taniguchi T; Iwano M
Biochimica et biophysica acta. Molecular and cell biology of lipids, 13 Feb. 2020, Peer-reviewed

Contribution of uremic dysbiosis to insulin resistance and sarcopenia.
Uchiyama K; Wakino S; IrieJ; Miyamoto J; Matsui A; Tajima T; Ito T; Oshima Y; Yoshifuji A; Kimura I; Itoh H
Nephrol Dial Transplant, 2020, Peer-reviewed

Synthetic dietary inulin, Fuji FF, delays development of diet-induced obesity by improving gut microbiota profiles and increasing short-chain fatty acid production.
Igarashi M; Morimoto M; Suto A; Nakatani A; Hayakawa T; Hara K; Kimura I*
PeerJ, 2020, Peer-reviewed, Corresponding author

Bifidobacterium animalis subsp. lactis GCL2505 modulates host energy metabolism via the short-chain fatty acid receptor GPR43
Horiuchi H; Kamikado K; Aoki R; Suganuma N; Nishijima T; Nakatani A; Kimura I
Sci Rep, 2020, Peer-reviewed

Commensal bacteria-derived butyrate promotes the T cell-independent IgA response in the colon.
Isobe J; Maeda S; Obata Y; Iizuka K; Nakamura Y; Fujimura Y; Kimizuka T; Hattori K; Kim YG; Morita T; Kimura I; Offermanns S; Adachi T; Nakao A; Kiyono H; Takahashi D; Hase K
Int Immunol, 2020, Peer-reviewed

Free Fatty Acid Receptors in Health and Disease.
Kimura I*, Ichimura A, Ohue-Kitano R, Igarashi M
Physiological reviews, 01 Jan. 2020, Peer-reviewed, Lead author, Corresponding author

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.
Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Ogawa J, Drucker DJ. Arita M, Itoh H, Kimura I*
Nature communications, 05 Sep. 2019, Peer-reviewed, Corresponding author

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.
Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K
Nature, Feb. 2019, Peer-reviewed

Dietary short-chain fatty acids intake improves the hepatic metabolic condition via FFAR3.
Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, Kimura I*
Sci Rep, 2019, Peer-reviewed, Corresponding author

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic condition.
Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I*
Proc Natl Acad Sci U S A, 2019, Peer-reviewed, Corresponding author

Regulation of host energy metabolism by gut microbiota-derived short-chain fatty acids.
Shimizu H; Ohue-Kitano R; Kimura I
Glycative Stress Res, 2019, Peer-reviewed, Corresponding author

Diet-Induced obese mice and leptin-deficient Lepob/ob mice exhibit increased circulating GIP levels produced by different mechanisms.
Lee EY; Miedzbrodzka E; Zhang X; Hatano R; Miyamoto J; Kimura I; Fujimoto K; Uematsu S; Rodriguez-Cuenca S; Vidal-Puig A; Gribble FM; Reimann F; Miki T
Int J Mol Sci, 2019, Peer-reviewed

3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice.
Ohue-Kitano R, Taira S, Watanabe K, Masujima Y, Kuboshima T, Miyamoto J, Nishitani Y, Kawakami H, Kuwahara H, Kimura I*
Nutrients, 2019, Peer-reviewed, Corresponding author

NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.
Igarashi M; Watanabe K; Tsuduki T; Kimura I; Kubota N
FASEB J, 2019, Peer-reviewed

Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.
Watanabe K; Igarashi M; Li X; Nakatani A; Miyamoto J; Inaba Y; Sutou A; Saito T; Sato T; Tachibana N; Inoue H; Kimura I*
PLoS One, Aug. 2018, Peer-reviewed, Corresponding author

Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner.
Nakatani A, Li X, Miyamoto J, Igarashi M, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H, Kimura I*
Biochemical and Biophysical Research Communications, 02 Jul. 2018, Peer-reviewed, Corresponding author

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.
Taka-Aki Koshimizu; Kenji Honda; Sachi Nagaoka-Uozumi; Atsuhiko Ichimura; Ikuo Kimura; Michio Nakaya; Nobuya Sakai; Katsushi Shibata; Kentarou Ushijima; Akio Fujimura; Akira Hirasawa; Hitoshi Kurose; Gozoh Tsujimoto; Akito Tanoue; Yukio Takano
Nature Neurosci, Jun. 2018, Peer-reviewed

Barley β-glucan improves metabolic condition via short-chain fatty acids produced by gut microbial fermentation in high fat diet fed mice
Junki Miyamoto; Keita Watanabe; Satsuki Taira; Mayu Kasubuchi; Xuan Li; Junichiro Irie; Hiroshi Itoh; Ikuo Kimura
PLoS ONE, 01 Apr. 2018, Peer-reviewed, Corresponding author

GPR41 / FFAR3.
Nakajima A; Kimura I
Encyclopedia of Signaling Molecules 2nd edition, Jan. 2018, Peer-reviewed, Corresponding author

Alpha-linolenic acid-derived metabolites from lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophage through G protein-coupled receptor 40.
Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park SB, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh YS, Jheng HF, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani F, Shimatsu A, Ogawa J, Satoh-Asahara N, Kawada T
FASEB J., 01 Jan. 2018, Peer-reviewed

An enteral formula containing fermented milk products and prebiotics promotes Glucagon-Like Peptide-1 secretion via short chain fatty acid signaling.
Kume H; Okazaki K; Yamamoto N; Omae Y; Ashida K; Takahashi T; Kimura I
J Nutr Food Sci, Jan. 2018, Peer-reviewed

Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway.
Lee EY; Zhang X; Miyamoto J; Kimura I; Tanaka T; Furusawa K; Jomori T; Fujimoto K; Uematsu S; Miki T
J Endocrinol, 2018, Peer-reviewed

Gut microbial dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases.
Li X, Watanabe K, Kimura I*
Front Immunol., Dec. 2017, Peer-reviewed, Corresponding author

Maternal high fiber diet during pregnancy and lactation influences regulatory T cell differentiation in offspring in mice.
Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S
JOURNAL OF IMMUNOLOGY, Nov. 2017, Peer-reviewed

Membrane progesterone receptor beta (mPRb/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling.
Kasubuchi M, Watanabe K, Hirano K, Inoue D, Li X, Terasawa K, Konishi M, Itoh N, Kimura I*
SCIENTIFIC REPORTS, Jul. 2017, Peer-reviewed, Corresponding author

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages
Nakajima A, Nakatani A, Hasegawa S, Irie J, Ozawa K, Tsujimoto G, Suganami T, Itoh H, Kimura I*
PLOS ONE, Jul. 2017, Peer-reviewed, Corresponding author

Anti-inflammatory and insulin-sensitizing effects of free fatty acid receptors
Miyamoto J, Kasubuchi M, Nakajima A, Kimura I*
Handbook of Experimental Pharmacology, 2017, Peer-reviewed, Corresponding author

Gut microbial metabolites short-chain fatty acids and obesity.
Li X; Shimizu Y; Kimura I*
Biosci Microbiota Food Health., 2017, Peer-reviewed, Corresponding author

The role of short-chain fatty acid on blood pressure regulation.
Miyamoto J, Kasubuchi M,Nakajima A, Irie J, Itoh H, Kimura I*
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, Sep. 2016, Peer-reviewed, Corresponding author

Nutritional signaling via free fatty acid receptors.
Miyamoto J, Hasegawa S, Kasubuchi M, Ichimura A,Nakajima A, Kimura I*
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Apr. 2016, Peer-reviewed, Corresponding author

Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) neurons abolishes GnRH expression and leads to hypogonadism and infertility.
Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL
JOURNAL OF NEUROSCIENCE, Mar. 2016, Peer-reviewed

Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets.
Hasegawa S, Kasubuchi M, Terasawa K, Kimura I*
CURRENT DRUG TARGETS, 2016, Peer-reviewed, Corresponding author

Editorial: Obesity and Diabetes: Energy regulation by free fatty acid receptors.
Ichimura A, Kimura I*
FRONTIERS IN ENDOCRINOLOGY, Nov. 2015, Peer-reviewed, Corresponding author

Neudesin as a unique secreted protein with multi-functional roles in neural functions, tumorigenesis, and energy metabolism.
Ohta H, Kimura I, Konishi M, Itoh N
Frontiers in Molecular Biosciences, 19 May 2015, Peer-reviewed

Deletion of the neurotrophic factor neudesin prevents diet-induced obesity by increased sympathetic activity.
Ohta H, Konishi M, Kobayashi Y, Kishio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I*, Itoh N
SCIENTIFIC REPORTS, May 2015, Peer-reviewed, Corresponding author

Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.
Kasubuchi M, Hasegawa S, Hiramatsu T, Ichimura A, Kimura I*
NUTRIENTS, Apr. 2015, Peer-reviewed, Corresponding author

Radiofluorinated probe for PET imaging of fatty acid binding protein 4 in cancer.
Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, Saji H
NUCLEAR MEDICINE AND BIOLOGY, Feb. 2015, Peer-reviewed

A gut microbial metabolite of linoleic acid, 10-Hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway.
Miyamoto J, Mizukure T, Park SB, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, Tanabe S
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2015, Peer-reviewed

A novel antidiabetic therapy: Free fatty acids receptors as potential druggable targets.
Sekiguchi H, Kasubuchi M, Hasegawa S, Pelisch N, Kimura I, Ichimura A
Current diabetes reviews, 2015, Peer-reviewed

Free fatty acids receptors as therapeutic targets for the treatment of diabetes.
Ichimura A, Hasegawa S, Kasubuchi M, Kimura I*
FRONTIERS IN PHARMACOLOGY, Nov. 2014, Peer-reviewed, Corresponding author

Host energy regulation via SCFAs receptors, as dietary nutrition sensors, by gut microbiota.
Kimura I
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2014, Peer-reviewed, Lead author, Corresponding author

Role of free fatty acid receptors in the regulation of energy metabolism.
Hara T, Kashihara D, Ichimura A, Kimura I, Tsujimoto G, Hirasawa A
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Sep. 2014, Peer-reviewed

A rapid and efficient method for neuronal induction of the P19 embryonic carcinoma cell line.
Nakayama Y, Wada A, Inoue R, Terasawa K, Kimura I, Nakamura N, Kurosaka A
JOURNAL OF NEUROSCIENCE METHODS, Apr. 2014, Peer-reviewed

Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4.
Nishigori K, Temma T, Onoe S, Sampei S, Kimura I, Ono M, Saji H
PLOS ONE, Apr. 2014, Peer-reviewed

Regulation of energy homeostasis by GPR41.
Inoue D, Tsujimoto G, Kimura I*
FRONTIERS IN ENDOCRINOLOGY, 2014, Peer-reviewed, Corresponding author

The SCFA receptor GPR43 and energy metabolism.
Kimura I*, Inoue D, Hirano K, Tsujimoto G
FRONTIERS IN ENDOCRINOLOGY, 2014, Peer-reviewed, Lead author, Corresponding author

Gene dosage of Otx2 is important for fertility in male mice.
Larder R, Kimura I, Meadows JD, Clark D, Mayo S, Mellon PL
MOLECULAR AND CELLULAR ENDOCRINOLOGY, Sep. 2013, Peer-reviewed

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.
Kimura I*, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
NATURE COMMUNICATIONS, May 2013, Peer-reviewed, Lead author, Corresponding author

FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models.
Takeuchi M, Hirasawa A, Hara T, Kimura I, Hirano T, Suzuki T, Miyata N, Awaji T, Ishiguro M, Tsujimoto G
BRITISH JOURNAL OF PHARMACOLOGY, Apr. 2013, Peer-reviewed

Free fatty acid receptors and their role in regulation of energy metabolism.
Hara T, Kimura I, Inoue D, Ichimura A, Hirasawa A
Reviews of physiology, biochemistry and pharmacology, 2013, Peer-reviewed

Neurotrophic effects of neudesin in the central nervous system.
Kimura I*, Nakayama Y, Zhao Y, Konishi M, Itoh N
FRONTIERS IN NEUROSCIENCE, 2013, Peer-reviewed, Lead author, Corresponding author

Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins.
Kimura I*, Nakayama Y, Konishi M, Terasawa K, Ohta M, Itoh N, Fujimoto M
CURRENT PROTEIN & PEPTIDE SCIENCE, Nov. 2012, Peer-reviewed, Lead author, Corresponding author

Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.
Inoue D, Kimura I, Wakabayashi M, Tsumoto H, Ozawa K, Hara T, Takei Y, Hirasawa A, Ishihama Y, Tsujimoto G
FEBS LETTERS, May 2012, Peer-reviewed

Dysfunction of Lipid-sensor GPR120 leads to obesity in both mouse and human.
Ichimura A, Hirasawa A, Godefroy OP, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Komer A, Kiess W, Pigeyre M, Cajazzo R, Hul WV, Gaal LV, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P
NATURE, Mar. 2012, Peer-reviewed

Physiological functions of fatty acid receptors and their therapeutic potential.
Hara T; Hirasawa A; Ichimura A; Kimura I; Tsujimoto G
Nihon Yakurigaku Zasshi., 2012, Peer-reviewed

Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic Disorders.
Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G
JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2011, Peer-reviewed

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via GPR41.
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2011, Peer-reviewed, Lead author

Circadian regulation of intracellular G-protein signaling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.
Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H
NATURE COMMUNICATIONS, May 2011, Peer-reviewed

Structure-activity relationships of GPR120 agonists based on a docking simulation.
Sun Q; Hirasawa A; Hara T; Kimura I; Adachi T; Awaji T; Ishiguro M; Suzuki T; Miyata N; Tsujimoto G
MOLECULAR PHARMACOLOGY, Nov. 2010, Peer-reviewed

Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis.
Kimura I*, Nakayama Y, Konishi M, Kobayashi T, Mori M, Ito M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M
JOURNAL OF NEUROCHEMISTRY, Mar. 2010, Peer-reviewed, Lead author, Corresponding author

Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade.
Kimura I*, Konishi M, Asaki T, Furukawa N, Ukai K, Mori M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2009, Peer-reviewed, Lead author, Corresponding author

Ca2+ inhibits the association of memantine with N-methyl-D-aspartate (NMDA) receptor-gated ion channels.
Fujimoto M, Iida H, Homma T, Kimura I, Mori M, Hamana H
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2008, Peer-reviewed

Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b(5)-like heme/steroid-binding domain.
Kimura I*, Nakayama Y, Yamauchi H, Konishi M, Miyake A, Mori M, Ohta M, Itoh N, Fujimoto M
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2008, Peer-reviewed, Lead author, Corresponding author

Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish.
Wakahara T, Kusu N, Yamauchi H, Kimura I, Konishi M, Miyake A, Itoh N
DEVELOPMENTAL BIOLOGY, Mar. 2007, Peer-reviewed

Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.
Kimura I, Konishi M, Miyake A, Fujimoto M, Itoh N
J Neurosci Res ., 2006, Peer-reviewed, Lead author

Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity
Kimura I; M Yoshioka; M Konishi; A Miyake; N Itoh
JOURNAL OF NEUROSCIENCE RESEARCH, Feb. 2005, Peer-reviewed, Lead author

Misc.

液性因子noudesinによるエネルギー代謝調節機構の解明
太田紘也; 太田紘也; 小西守周; 中山喜明; 中尾一和; 菅波孝祥; 木村郁夫; 伊藤信行
日本内分泌学会雑誌, 01 Apr. 2017

食事由来ω脂肪酸代謝産物の宿主エネルギー代謝への影響
宮本潤基; 粕渕真由; 中島啓; 岸野重信; 入江潤一郎; 菅原達也; 有田誠; 小川順; 伊藤裕; 木村郁夫
日本内分泌学会雑誌, Apr. 2017

新規肥満症鍵分子neudesinの寒冷ストレス暴露による発現変化および機能解析
迎武紘; 太田紘也; 山田祐維; 中山喜明; 増田有紀; 木村郁夫; 伊藤信之; 小西守周
日本生化学会大会(Web), 2017

Physiological function of short-chain fatty acid receptor under ketogenic condition
Mayu Kasubuchi; Sae Hasegawa; Atsuhiko Ichimura; Ikuo Kimura
FASEB JOURNAL, Apr. 2016

A gut microbial metabolite of linoleic acid and gut homeostasis
Junki Miyamoto; Shigenobu Kishino; Takuya Suzuki; Jun Ogawa; Ikuo Kimura; Soichi Tanabe
FASEB JOURNAL, Apr. 2016

The role of short-chain fatty acid receptor-mediated macrophages in adipose tissue inflammation
Sae Hasegawa; Mayu Kasubuchi; Junki Miyamoto; Ikuo Kimura
FASEB JOURNAL, Apr. 2016

分泌性因子neudesinの遺伝子欠損マウスは交感神経活性の亢進により食餌誘導性肥満に耐性を示す
太田紘也; 小西守周; 橋本大嗣; 樫尾篤樹; 持山喬之; 松村成暢; 井上和生; 伏木亨; 中山喜明; 中尾一和; 木村郁夫; 伊藤信行
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

Host energy regulation by short-chain fatty acids receptors through diet and gut microbiota
Ikuo Kimura; Gozoh Tsujimoto
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

細胞膜上プロゲステロン受容体群の組織における発現とその細胞内シグナルの検討
平野加奈子; 寺澤和哉; 中山喜明; 小西守周; 伊藤信行; 木村郁夫
日本分子生物学会年会プログラム・要旨集(Web), 2014

DEVELOPMENT OF A NOVEL RADIOFLUORINATED PROBE FOR PET IMAGING OF FATTY ACID BINDING PROTEIN 4 IN GLIOBLASTOMA
Temma T; Nishigori K; Kimura I; Ono M; Saji H
XIII Turku PET Symposium, 2014, Peer-reviewed

新規分泌性因子Neudesinの遺伝子欠損マウスは食餌誘導性肥満に耐性を示す
樫尾篤樹; 太田紘也; 小林祐介; 杉村絵理; 小西守周; 木村郁夫; 松村成暢; 井上和生; 伏木亨; 伊藤信行
日本分子生物学会年会プログラム・要旨集(Web), 2013

Structure-activity relationships of free fatty acid receptors GPR40 and GPR120 agonists based on a docking simulation
Takafumi Hara; Akira Hirasawa; Masato Takeuchi; Kumiko Ayukawa; Ryohei Shirai; Ikuo Kimura; Takayoshi Suzuki; Naoki Miyata; Gozoh Tsujimoto
FASEB JOURNAL, Apr. 2012

Short-chain fatty acids activate sympathetic neurons via a novel signaling pathway
Daisuke Inoue; Ikuo Kimura; Kentaro Ozawa; Yosinori Takei; Akira Hirasawa; Gozoh Tsujimoto
FASEB JOURNAL, Apr. 2012

カリフォルニア大学サンディエゴ校・Pamela Mellon Labに留学して
木村郁夫
血管, 2012

Role of free fatty acid receptor GPR120 in metabolic regulation
Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Satoshi Miyauchi; Ikuo Kimura; Koshimizu Taka-aki; Gozoh Tsujimoto
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

Neudesin, a Neurotrophic Factor, Is a Novel Extracellular Heme-binding Protein
Ikuo Kimura; Yoshiaki Nakayama; Masahiro Mori; Mitsuhiro Ohta; Nobuyuki Itoh; Masafumi Fujimoto
FASEB JOURNAL, Apr. 2008

Presentations

微生物が作る食物繊維、菌体外多糖による代謝機能改善「食物繊維の疾患予防・治療への可能性」
木村郁夫
第20回日本機能性食品医用学会, 04 Dec. 2022, Invited

腸内細菌代謝産物、短鎖脂肪酸と肥満
木村郁夫
第43回肥満学会・第40回肥満症治療学会, 02 Dec. 2022, Invited

腸内代謝物と宿主の健康「シンポストバイオの潮流～腸内代謝物の有益性と商品化」
木村郁夫
第74回日本生物工学会大会, 19 Oct. 2022, Invited

短鎖脂肪酸受容体と代謝・肥満
木村郁夫
第44回日本臨床栄養学会総会, 09 Oct. 2022, Invited

ケトン体受容体による脂質代謝制御「食品・栄養素による生体調節 Update」
木村郁夫
第44回日本臨床栄養学会総会, 08 Oct. 2022, Invited

腸内細菌代謝産物による宿主エネルギー制御
木村郁夫
第34回微生物シンポジウム[Web開催：ライブ配信], 31 Aug. 2022, Invited

脂肪酸受容体と腸内細菌「腸内細菌と脂肪酸を理解しよう」
木村郁夫
第54回日本動脈硬化学会総会, 23 Jul. 2022, Invited

宿主代謝制御と腸内細菌叢「腸内細菌の最新の話題」
木村郁夫
第70回日本化学療法学会総会, 04 Jun. 2022, Invited

腸内細菌代謝産物、短鎖脂肪酸と肥満
木村郁夫
京都消化器医会定例学術講演会, 14 May 2022, Invited

短鎖脂肪酸受容体と代謝・肥満
木村郁夫
腸内微生物叢研究の最前線, 25 Apr. 2022, Invited

肥満症と腸内細菌
木村郁夫
第13回肥満症総合治療セミナー, 08 May 2022, Invited

腸内細菌による糖代謝と宿主肥満「肥満症における腸管の意義」
木村郁夫
第42回日本肥満学会・第39回日本肥満症治療, 27 Mar. 2022, Invited

腸内細菌と肥満症
木村郁夫
第42回日本肥満学会・第39回日本肥満症治療, 26 Mar. 2022, Invited

中鎖脂肪酸・ケトン体受容体による食・栄養シグナル
木村郁夫
第24回健康栄養シンポジウム[Web開催：ライブ配信], 19 Mar. 2022, Invited

ケトン体受容体と栄養シグナル「ケトン体の生理的意義を考える」
木村郁夫
第24・25回日本病態栄養学会年次学術集会[Web開催：ライブ配信], 29 Jan. 2022, Invited

脂肪酸受容体と食・栄養シグナル
木村郁夫
第19回日本機能性食品医用学会総会[Web開催：ライブ配信], 11 Dec. 2021, Invited

脂肪酸受容体と栄養シグナル
木村郁夫
第60回栄養・食糧学会近畿支部大会 [Web開催：ライブ配信], 27 Nov. 2021, Invited

脂肪酸受容体と食・栄養シグナル「食品･栄養成分の臓器間ネットワークを介した生体調節機能」
木村郁夫
第26回フードファクター学会大会[Web開催：ライブ配信], 20 Nov. 2021, Invited

ポリフェノール代謝物による生体生理機能への分子作用機序「腸内環境研究から次世代機能性食品開発を考える」
木村郁夫
食品開発展2021記念セミナー, 06 Oct. 2021, Invited

腸内細菌発酵産物による抗肥満メカニズム
木村郁夫
第5回発酵と酵素の機能食品研究会定期大会 [Web開催], 04 Jul. 2021, Invited

食用油の腸内細菌代謝と肥満の関係
木村郁夫
第21回日本抗加齢医学会総会, 26 Jun. 2021, Invited

ケトジェニック環境下における短鎖脂肪酸受容体の役割「腸管による代謝調節と糖尿病」
木村郁夫
第64回日本糖尿病学会年次学術集会 [Web開催], 22 May 2021, Invited

腸内細菌代謝産物と肥満
木村郁夫
第107回日本消化器病学会総会, 15 Apr. 2021, Invited

腸内代謝産物と肥満
木村郁夫
第７回Joy of Fatty Acids Secrets/Society (JFAS) [Web開催], 07 Feb. 2021, Invited

食・栄養シグナルと脂肪酸受容体
木村郁夫
第10回生理化学ユニットシンポジウム, 25 Dec. 2020, Invited

加齢による腸内環境変化と脂肪酸受容体を介した宿主のエネルギー代謝制御「腸内環境からみた老化・栄養・生体防御の相互連関」
木村郁夫
第43回日本分子生物学会年会 [Web開催], 04 Dec. 2020, Invited

腸内細菌による食用油由来、多価不飽和脂肪酸代謝と肥満への影響
木村郁夫
第35回水産油脂技術懇話会 [Web開催], 27 Nov. 2020, Invited

腸内細菌と代謝「腸内環境をデザインする」
木村郁夫
キックオフミーティング腸内デザイン学会, 19 Nov. 2020, Invited

腸内細菌代謝産物と短鎖脂肪酸受容体「腸内細菌の基礎と臨床」
木村郁夫
第22回日本神経消化器病学会総会, 19 Nov. 2020, Invited

腸内細菌による多価不飽和脂肪酸代謝と肥満「糖尿病・糖尿病合併症発症機序における臓器連関」
木村郁夫
第63回日本糖尿病学会年次学術集会 [Web開催], 23 Oct. 2020, Invited

腸内細菌と宿主エネルギー代謝
木村郁夫
機能性食品分科会第４回会合 [Web開催], 30 Jul. 2020, Invited

腸内細菌代謝産物と脂肪酸受容体「腸内細菌アップデート」
木村郁夫
第93回日本内分泌学会学術総会 [Web開催], 27 Jul. 2020, Invited

短鎖脂肪酸とDOHaD 「Developmental Origins of Health and Disease (DOHaD) と腸内細菌」
木村郁夫
第24回腸内細菌学会学術集会 [誌上開催], 12 Jun. 2020, Invited

乳酸菌と短鎖脂肪酸、そして代謝疾患制御「乳酸菌：その健康有益性の検討」
木村郁夫
第74回日本栄養・食糧学会大会 [誌上開催], 17 May 2020, Invited

腸内細菌代謝産物と肥満
木村郁夫
ビタミンB研究委員会2019年度シンポジウム [誌上開催], 06 Mar. 2020, Invited

Metabolism of dietary omega-6 fatty acids by gut microbiota and host energy regulation. [The importance of Lipid Quality (Lipoquality) in Health and Disease]
I. Kimura
The 9th International Conference on Polyphenols and Health (ICoFF2019), 04 Dec. 2019, Invited

The evaluation of host metabolic benefits by dietary intake of exopolysaccharides derived from lactic acid bacteria. [Novel approach to food and heath by lactic acids bacteria products exopolysaccharides]
I. Kimura
The 9th International Conference on Polyphenols and Health (ICoFF2019), 02 Dec. 2019, Invited

腸内細菌による多価不飽和脂肪酸代謝と宿主恒常性への影響「腸内環境とホメオスタシス」
木村郁夫
第44回比較内分泌学会, 09 Nov. 2019, Invited

短鎖脂肪酸と肥満
木村郁夫
第40回肥満学会, 03 Nov. 2019, Invited

腸内細菌によるオメガ6脂肪酸代謝と宿主恒常性への影響「肥満症における免疫・炎症・腸内細菌
木村郁夫
第40回肥満学会, 03 Nov. 2019, Invited

食由来腸内細菌代謝産物と宿主エネルギー代謝制御
木村郁夫
第14回日本杜仲研究会, 27 Jul. 2019, Invited

腸内細菌代謝産物と宿主恒常性
木村郁夫
第41回日本疼痛学会, 13 Jul. 2019, Invited

菌体外多糖と肥満・糖尿病「腸内細菌叢由来代謝物質がもたらす生体恒常性と疾患」
木村郁夫
第19回日本抗加齢医学会総会, 14 Jun. 2019, Invited

食由来栄養素と脂肪酸受容体 JES We Can「肥満の科学的アプローチ」
木村郁夫
第92回日本内分泌学会学術総会, 11 May 2019, Invited

腸内細菌由来短鎖脂肪酸と宿主代謝制御
木村郁夫
神戸大農工バイオプロダクション次世代農工連携拠点主催フォーラム「腸内から望む先制医療の行方」, 31 Jan. 2019, Invited

腸内細菌の代謝物とその機能「腸内細菌と健康と疾病研究の動向とICT人材の育成
木村郁夫
第２回「D2Kサイエンティスト緊急養成研究集会」, 21 Dec. 2018, Invited

食由来腸内代謝産物と肥満
木村郁夫
岐阜薬科大機能性健康食品研究講演会, 01 Dec. 2018, Invited

腸内細菌代謝産物と宿主エネルギー代謝ネットワークの統合的理解「腸内細菌と臓器－健康と疾病－」
木村郁夫
Visionary農芸化学100, 18 Nov. 2018, Invited

食由来腸内細菌代謝産物による宿主エネルギー代謝制御
木村郁夫
第161回日本獣医学会学術集会, 12 Sep. 2018, Invited

食物繊維・短鎖脂肪酸・生活習慣病克服への展望「オリゴ糖・多糖類研究の新知見」
木村郁夫
Food Congress 2018, 08 Sep. 2018, Invited

メタボリックシンドロームと腸内細菌「腸内細菌とメタボリックシンドローム」
木村郁夫
第33回日本乾癬学会, 07 Sep. 2018, Invited

食由来脂肪酸と脂肪酸受容体を介したエネルギー代謝制御「脂質栄養の最前線」
木村郁夫
脂質栄養学会第27回大会, 31 Aug. 2018, Invited

腸内細菌代謝産物と肥満
木村郁夫
JBAセミナー・未来へのバイオ技術勉強会, 27 Jul. 2018, Invited

腸内細菌代謝産物と宿主エネルギー代謝制御
木村郁夫
ウェルネスフードジャパン2018, 26 Jul. 2018, Invited

性ステロイドホルモンによる即時性反応を介した高次生理機能
木村郁夫
第45回日本毒性学会, 18 Jul. 2018, Invited

Host energy regulation by gut microbial metabolites 「New trends in microbiome research-微生物叢研究の新展開-」
木村郁夫
第22回腸内細菌学会, 31 May 2018, Invited

脂肪酸受容体と栄養‐神経‐エネルギー代謝制御「消化管と脳・神経系を結ぶ食品因子研究の新機軸」
木村郁夫
2018農芸化学会, 18 Mar. 2018, Invited

食由来腸内代謝産物と生体エネルギー制御
木村郁夫
第30回産学官若手交流会さんわか, 19 Jan. 2018, Invited

食由来腸内細菌発酵産物と宿主エネルギー代謝「脂質・エネルギー代謝、腸内細菌研究の最前線」
木村郁夫
第22回食物繊維学会, 25 Nov. 2017, Invited

腸内細菌と脂肪酸受容体を介した宿主エネルギー代謝制御
木村郁夫
食品免疫学会第12回宿泊セミナー, 17 Nov. 2017, Invited

母体腸内細菌叢と肥満：世代間連関「長期時間軸における生体変化と食品機能」
木村郁夫
第13回食品免疫学会, 10 Nov. 2017, Invited

腸内細菌、栄養シグナル、短鎖脂肪酸、肥満「栄養シグナルと生体応答」
木村郁夫
第39回日本臨床栄養学会, 14 Oct. 2017, Invited

共生菌による食事由来オメガ6脂肪酸代謝を介した宿主エネルギー恒常性制御
木村郁夫
BioJapan2017, 11 Oct. 2017, Invited

腸内代謝産物と肥満「肥満症と消化管制御」
木村郁夫
第38回日本肥満学会, 08 Oct. 2017, Invited

難消化性多糖の腸内環境改善メカニズム解明と機能性素材開発「腸内細菌から考えるこれからの機能性食品開発」
木村郁夫
食品開発展2017, 04 Oct. 2017, Invited

腸内細菌由来短鎖脂肪酸と肥満
木村郁夫
第61回日本薬学会関東支部会, 16 Sep. 2017, Invited

Dietary gut microbial metabolites and host energy homeostasis Symposia Session [Gut Microbiota: The Game Changer in Obesity?]
Ikuo Kimura
2017 International Congress on Obesity and Metabolic Syndrome (ICOMES), 02 Sep. 2017, Invited

食－腸内代謝物を介した宿主エネルギー代謝制御と脂肪酸受容体
木村郁夫
第169回分泌セミナー, 01 Jul. 2017, Invited

腸内細菌と代謝
木村郁夫
第21回睡眠科学研究講座, 28 Jun. 2017, Invited

腸内細菌代謝産物と肥満症治療「腸内細菌と肥満症・糖尿病」
木村郁夫
第35回日本肥満症治療学会, 23 Jun. 2017, Invited

腸内細菌由来代謝産物と宿主エネルギー代謝「腸内細菌と代謝」
木村郁夫
第17回日本抗加齢医学会総会, 02 Jun. 2017, Invited

腸内代謝脂肪酸による生体エネルギー代謝機構「脂質機能に関する新展開」
木村郁夫
第71回食糧・栄養学会, 20 May 2017, Invited

食由来栄養センサー脂肪酸受容体とエネルギー代謝制御
木村郁夫
第14回GPCR研究会, 13 May 2017, Invited

Gut microbiota and obesity Symposia Session [Gut microbiota and GI diseases]
Ikuo Kimura
5th Biennial Congress of the Asian Neurogastroenterology & Motility Association (ANMA), 23 Mar. 2017, Invited

内なる生態系からのメッセージ～腸内細菌のチカラ～
木村郁夫
農芸化学会2017, 18 Mar. 2017, Invited

腸内細菌代謝産物による宿主エネルギー制御機構「代謝異常と腸内細菌」
木村郁夫
第51回糖尿病学の進歩, 18 Feb. 2017, Invited

太るか痩せるかは、腸内細菌が作る化学物質に依存する「ヒトの菌を化学で解明」
木村郁夫
第6回CSJ化学フェスタ2016, 15 Nov. 2016, Invited

腸内細菌と臓器相関
木村郁夫
第54回小腸研究会, 12 Nov. 2016, Invited

腸内細菌によるエネルギー代謝調節機構「イムノメタボリズムと肥満症」
木村郁夫
第37回日本肥満学会, 08 Oct. 2016, Invited

食由来腸内細菌代謝産物による宿主エネルギー制御機構の解明と機能性食品開発「腸内細菌の全容解明と新たな機能性食品開発」
木村郁夫
食品開発展2016, 05 Oct. 2016, Invited

食由来脂肪酸代謝物による腸を起点としたエネルギー制御機構「腸内環境のメタボロミクス」
木村郁夫
フォーラム2016 衛生薬学・環境トキシコロジー, 11 Sep. 2016, Invited

腸内細菌とメタボエイジング
木村郁夫
第8回抗加齢内分泌研究会, 04 Sep. 2016, Invited

食と腸内細菌代謝産物を介した宿主のエネルギー制御機構
木村郁夫
フードフォーラムつくば2016夏の例会, 07 Jul. 2016, Invited

食由来腸内細菌代謝産物と宿主代謝機能
木村郁夫
第4回JCHMシンポジウム, 08 Jun. 2016, Invited

腸内細菌代謝産物、短鎖脂肪酸と肥満「腸内細菌叢と疾患」
木村郁夫
第63回日本実験動物学会総会, 18 May 2016, Invited

腸内細菌代謝産物、短鎖脂肪酸と肥満
木村郁夫
プロバイオティクスシンポジウム’16, 12 May 2016, Invited

Host beneficial metabolic effects by gut microbial metabolites, short-chain fatty acids. Hot Topics Symposia Session [Gut Microbiome Effects on Human Health]
Ikuo Kimura
107th AOCS Annual Meeting & Expo, 02 May 2016, Invited

食物繊維、腸内細菌、短鎖脂肪酸と宿主代謝制御「腸内細菌と肥満・糖代謝」
木村郁夫
第89回日本内分泌学会学術総会, 22 Apr. 2016, Invited

腸内細菌とつむぐ健康～人と腸内細菌との多様な対話を紐解く～
木村郁夫
日本農芸化学会2016年度大会, 28 Mar. 2016, Invited

腸内細菌代謝産物、短鎖脂肪酸によるエネルギー代謝調節と分子機構「消化管から脳への情報発信と全身機能制御」
木村郁夫
第93回日本生理学会大会, 23 Mar. 2016, Invited

脂肪酸受容体とエネルギー代謝「脂肪酸と炎症」
木村郁夫
第6回機能油脂懇話会, 14 Nov. 2015, Invited

腸内細菌代謝産物とエネルギー代謝疾患「腸内細菌と主体機能の新たな展開」
木村郁夫
第17回日本神経消化器病学会, 13 Nov. 2015, Invited

短鎖脂肪酸とエネルギー代謝
木村郁夫
腸内フローラシンポジウム, 30 Oct. 2015, Invited

Host beneficial metabolic effects by microbial metabolites, short-chain fatty acids.
Ikuo Kimura
Kyoto Conference of Young Lions in Obesity Research, 05 Oct. 2015, Invited

腸内細菌と代謝疾患-食由来腸内代謝脂質による抗肥満メカニズムの解明- 「腸内環境と健康・疾患予防」
木村郁夫
明治大学公開講演会, 03 Oct. 2015, Invited

腸内細菌代謝脂質と宿主エネルギー恒常性
木村郁夫
第33回内分泌代謝学サマーセミナー, Jul. 2015, Invited

腸内細菌代謝産物と肥満「解析がすすむ腸内フローラと疾患との関わり」
木村郁夫
第15回日本抗加齢医学会総会, May 2015, Invited

腸内細菌、短鎖脂肪酸受容体と肥満「肥満・慢性疾患・老化など人の健康に影響を与える微生物」
木村郁夫
第88回日本細菌学会, Mar. 2015, Invited

The short-chain fatty acid receptors and host energy regulation by gut microbiota.
Ikuo Kimura
International symposium on Homeostasis through development, life, and diseases, Nov. 2014, Invited

腸内細菌代謝産物と健康「腸管機能と健康」
木村郁夫
第17回日本補完代替医療学会, Nov. 2014, Invited

Host energy regulation by gut microbial metabolites sensors 若手の会シンポジウム「Regulation of feeding and metabolism by intestinal function」
木村郁夫
第48回日本味と匂学会, Oct. 2014, Invited

腸内細菌と短鎖脂肪酸「肥満と腸内環境」
木村郁夫
第35回日本肥満学会, Oct. 2014, Invited

腸内細菌叢による体脂肪蓄積抑制機構の解明
木村郁夫
第19回アディポサイエンス・シンポジウム「白色・褐色脂肪細胞の分化・増殖と機能」, Aug. 2014, Invited

食と腸内細菌による短鎖脂肪酸受容体を介した宿主エネルギー代謝制御シンポジウム「脂質の生体内ADME（吸収から排泄まで）」
木村郁夫
脂質栄養学会第23回大会, Aug. 2014, Invited

食と腸内細菌：短鎖脂肪酸受容体と生活習慣病
木村郁夫
第7回食品免疫学会「これからの食品免疫学」, Jun. 2014, Invited

腸内細菌と短鎖脂肪酸「脂肪酸の病態栄養学」
木村郁夫
第17回日本病態栄養学会年次学術集会, Jan. 2014, Invited

GPR41, short-chain fatty acids receptor, modulates metabolic activity via sympathetic nervous system.
Ikuo Kimura
6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects (IRS 2011), Apr. 2011, Invited

Books and Other Publications

腸内細菌が作り出す生理活性脂質
宮本潤基,木村郁夫, Joint work, Vol.59, No.1, p14-18 ファルマシア
2023

遺伝子医学
宮本潤基; 木村郁夫, Joint work, Vol.12 No.4, p62-67「母体腸内細菌による胎仔疾患感受性の制御」
2022

The Lipid
西田朱里; 泉綾乃; 池田貴子; 木村郁夫, Joint work, Vol.33 No.2, p40-46「代謝制御におけるケトン体受容体の役割」
2022

Microbiome Science
山野真由; 木村郁夫, Joint work, Vol.1 No.1, p49-52「腸内細菌叢は宿主の社会行動を制御する」
2022

循環器内科
塩野勝之; 北野(大植)隆司; 木村郁夫, Joint work, Vol.92 No.1, p77-83「ケトン体の新たな受容体の発見の意義」
2022

消化器・肝臓内科
山口一樹; 加藤裕教; 木村郁夫, Joint work, Vol.11 No.4, p436-444「食物繊維と臓器相関」
2022

実験医学（増刊号）
宮本潤基; 中谷明穂; 木村郁夫, Joint work, Vol.35, No.20, p103-108「老化・代謝制御における腸内細菌叢」
2017

BIO Clinica
宮本潤基; 渡辺啓太; 木村郁夫, Joint work, Vol.32, No.14, p19-23「腸内細菌による脂肪酸代謝と宿主への影響」
2017

月刊BIO INDUSTRY
宮本潤基; 木村郁夫, Joint work, Vol.34, No.11, p9-13「食事の健康に与える影響～腸内細菌の働き解明～」
2017

Clinical Neuroscience
細野加奈子; 中谷明穂; 木村郁夫, Joint work, Vol.35, No.11, p1301-1303「腸内細菌の肥満・糖尿病などのエネルギー代謝疾患への関与」
2017

食と医療
木村郁夫, Joint work, Vol.2, p13-23「炭水化物（食物繊維）と腸内細菌」
2017

内分泌・糖尿病・代謝内科
宮本潤基; 渡辺啓太; 木村郁夫, Joint work, Vol.45, No.1, p7-13「代謝制御における食物繊維・短鎖脂肪酸の関与」
2017

消化と吸収
粕渕真由; 木村郁夫; 國澤純, Joint work, Vol.39, No.2 p66-70「腸内環境と腸管免疫・生体防御に関する新しいトピックス」
2017

Helicobacter Research
粕渕真由; 宮本潤基; 木村郁夫, Joint work, Vol.21, No.3 p38-43「肥満と腸内細菌」
2017

月刊糖尿病
中島啓; 木村郁夫, Joint work, Vol.9, No.5, p17-24「腸内細菌によるエネルギー代謝制御機構」
2017

化学と生物
宮本潤基; 鈴木卓弥; 木村郁夫; 田辺創一, Joint work, Vol.55, No.4, p278-284「腸内細菌脂質代謝物に見いだされた腸管バリア保護機能」
2017

実験医学（増刊号）
中島啓; 木村郁夫, Joint work, Vol.35, No.2, p145-151「腸内細菌叢を介した宿主エネルギー代謝と免疫制御機構‐糖尿病治療に向けて」
2017

生命誌年間号つむぐ
木村郁夫, Joint work, Vol.84-87, p107-112「腸内環境と宿主の肥満をつなぐ受容体」
2016

最新医学
中島啓; 宮路茜; 木村郁夫, Joint work, Vol.71, No.9, p1787-1794「腸内細菌による宿主エネルギー代謝制御機構」
2016

食品と開発
木村郁夫, Joint work, Vol.51, No.11, p66-68「特別レポート：食と腸内細菌代謝産物を介した宿主のエネルギー代謝制御」
2016

腸内フローラシンポジウム
木村郁夫, Joint work, Vol.24, p31-35「食物繊維由来腸内細菌代謝産物、短鎖脂肪酸とエネルギー代謝」
2016

フードスタイル21
木村郁夫; 宮路茜; 中島啓, Joint work, Vol.20, No.8, p44-47「腸内細菌代謝産物、短鎖脂肪酸と肥満」
2016

臨牀消化器内科
粕渕真由; 宮本潤基; 中島啓; 木村郁夫, Joint work, Vol.31, No.9, p1255-1260「腸内細菌叢と食欲」
2016

Diabetes Frontier
木村郁夫; 粕渕真由; 宮本潤基, Joint work, Vol.27, No.3, p302-308「腸内環境のフロンティア」
2016

機能性食品と薬理栄養
宮本潤基; 粕渕真由; 中島啓; 木村郁夫, Joint work, Vol.10, No.1, p414-420「腸内細菌とエネルギー代謝」
2016

Pharma Medica
中島啓; 木村郁夫, Joint work, Vol.34, No.5, p.21-26「腸内細菌による宿主エネルギー代謝制御機構」
2016

The Lipid
宮本潤基; 粕渕真由; 長谷川沙恵; 木村郁夫, Joint work, Vol.27, No.2, p32-39「腸内細菌と短鎖脂肪酸」
2016

食品と開発
木村郁夫; 長谷川沙恵; 粕渕真由; 宮本潤基, Joint work, Vol.51, No.4, p8-10「食由来腸内細菌代謝産物、短鎖脂肪酸の代謝制御機能」
2016

実験医学
木村郁夫; 粕渕真由; 長谷川沙恵, Joint work, Vol.34, No.6, p880-885「腸内環境制御と肥満・糖尿病治療戦略」
2016

ヒトマイクロバイオーム研究最前線
宮本潤基; 長谷川沙恵; 木村郁夫, Joint work, 第2章 1節, p203-208「腸内細菌叢と肥満（脂質）」
2016

診断と治療
長谷川沙恵; 粕渕真由; 木村郁夫, Joint work, Vol.104, No.2, p233-238「腸内細菌の代謝に果たす役割」
2016

医学のあゆみ特集号
木村郁夫; 粕渕真由, Joint work, Vol.256, No.5, p541-546「GPCR研究の最前線2016：食事性栄養センサー脂肪酸受容体」
2016

肝胆膵
粕渕真由; 長谷川沙恵; 木村郁夫, Joint work, Vol.70, No.6, p821-826「ヒト腸内細菌とエネルギー代謝」
2015

脂質栄養学
木村郁夫; 長谷川沙恵; 粕渕真由, Joint work, Vol.24, No.1, p33-40「食事由来腸内細菌代謝産物、短鎖脂肪酸と宿主代謝制御」
2015

化学と生物
木村郁夫, Joint work, Vol.53, No.4, p202-204「食と腸内細菌代謝産物を介した宿主エネルギー制御機構」
2015

Annual Review 糖尿病・代謝・内分泌 2015
木村郁夫, Joint work, p170-176「脂肪酸受容体によるエネルギー代謝制御」
2015

月刊糖尿病 1月号
木村郁夫, Joint work, Vol.7, No.1, p42-48「消化管細菌からみた糖尿病の病態と治療」
2015

消化と吸収
木村郁夫; 粕渕真由; 長谷川沙恵, Joint work, Vol.37, No.2, p62-66「代謝調節における脂肪酸受容体のもたらす新しい世界」
2014

医学のあゆみ特集号
木村郁夫, Joint work, Vol.251, No.1, p107-111「腸内細菌と肥満：腸内細菌代謝産物と宿主エネルギー制御」
2014

ファルマシア
木村郁夫, Joint work, Vol.50, No.9, p867-871「創薬応用を目指した脂肪酸受容体の機能解析「最前線」」
2014

実験医学（増刊号）
木村郁夫, Joint work, Vol.32, No.5, p768-772「肥満と腸内細菌-宿主のエネルギー代謝調節と短鎖脂肪酸受容体-」
2014

血管
市村敦彦; 原貴史; 木村郁夫; 平澤明; 辻本豪三, Joint work, Vol.34, No.4, p145-152「創薬標的としての遊離脂肪酸受容体：循環器疾患とメタボリックシンドローム」
2011

医学のあゆみ
木村郁夫; 辻本豪三, Joint work, Vol.239, No.2, p170-171「腸内細菌と脂肪酸受容体を介したエネルギー調節機構」
2011

血管
木村郁夫; 井上大輔; 前田岳志; 宮内諭; 市村敦彦; 平澤明; 辻本豪三, Joint work, Vol.33, No.3, p81-87「脂肪酸受容体：メタボリックシンドロームと循環器系疾患」
2010

糖尿病・内分泌代謝科
野仲葉月; 大植隆司; 木村郁夫, Joint work, Vol.54 No.1, p52-60「妊娠期の腸内環境と子供の代謝」
2022

実験医学（増刊号）
池田貴子; 西田朱里; 山野真由; 木村郁夫, Joint work, Vol.40 No.7, p98-104「栄養環境の変化を認識する短鎖脂肪酸受容体」
2022

食品免疫学事典
木村郁夫, Joint work, 7章 11節「短鎖脂肪酸」
2021

Medical Practice
宮本潤基; 木村郁夫, Joint work, Vol.38 No.7, p1017-1020「腸内環境と肥満」
2021

エッセンシャル栄養化学
木村郁夫, Joint work, 第11章 p229-246「食物繊維と腸内細菌」
2021

糖尿病・内分泌代謝科
早川徹彦; 森本深玖; 田邉はるか; 五十嵐美樹; 木村郁夫, Joint work, Vol.52 No.5, p469-475「脂肪酸受容体」
2021

糖尿病学2021
渡辺啓太; 西田朱里; 宮本潤基; 木村郁夫, Joint work, p17-25「妊娠中の食物繊維摂取と胎児の代謝」
2021

化学と生物
西田朱里; 宮本潤基; 木村郁夫, Joint work, Vol.59 No.6, p264-266「ケトン体（アセト酢酸）の受容体を介した脂質代謝」
2021

医学のあゆみ
大植隆司; 西田朱里; 木村郁夫, Joint work, Vol.276 No.12, p1098-1103「ケトン体による生体機能制御」
2021

実験医学（増刊号）
大植隆司; 加藤裕教; 木村郁夫, Joint work, Vol.39 No.5, p188-194「腸内細菌と肥満症」
2021

生化学
宮本潤基; 渡辺啓太; 木村郁夫, Joint work, 93巻 1号 p52-58「食と腸内細菌による宿主の代謝制御」
2021

腸内微生物叢最前線
大植隆司; 清水秀憲; 木村郁夫, Joint work, p12-16「腸内微生物叢と代謝制御システム」
2021

Pharma Medica
西田朱里; 宮本潤基; 大植隆司; 木村郁夫, Joint work, Vol.38 No.9, p79-83「低炭水化物食における分子栄養メカニズム」
2020

医学のあゆみ特集号
渡辺啓太; 宮本潤基; 長谷耕二; 木村郁夫, Joint work, Vol.275 No.9, p952-956「胎児期・乳児期の腸内細菌叢の長期的影響」
2020

Pharma Medica
宮本潤基; 渡辺啓太; 木村郁夫, Joint work, Vol.38 No.12, p37-40「腸内細菌とDOHaD学説」
2020

日本医師会雑誌
木村郁夫, Joint work, Vol.149 No.9, p1543-1546「腸内細菌とエネルギー代謝」
2020

臨床免疫・アレルギー科
宮本潤基; 吉本亜由美; 渡辺啓太; 木村郁夫; 長谷耕二, Joint work, Vol.74 No.5, p508-513「妊娠中の母体の代謝がこどもに与える影響」
2020

糖尿病・内分泌代謝科
渡辺啓太; 向山広美; 宮本潤基; 木村郁夫, Joint work, Vol.51 No.1, p1-7「食由来栄養シグナルと腸内環境を介した宿主エネルギー代謝制御」
2020

ヒトマイクロバイオーム最前線
向山広美; 宮本潤基; 木村郁夫, Joint work, 第4編第5章 Vol.2 p393-399「腸内細菌叢と肥満（脂質）」
2020

糖尿病学会誌
水島莉那; 後田ちひろ; 木村郁夫, Joint work, Vol.63, No.6「短鎖脂肪酸を介した宿主のエネルギー・糖代謝調節」
2020

バイオサイエンスとインダストリー（B&I）
渡辺啓太; 向山広美; 宮本潤基; 木村郁夫, Joint work, Vol.78, No.3, p196-201「ケトン体生成を促す食事療法による体脂肪減少メカニズム」
2020

実験医学別冊もっとよくわかる！腸内細菌叢
木村郁夫, Joint work, 第2部6章-2 p69-72「代謝性疾患」
2019

腸内環境改善食物繊維の技術と市場
宮本潤基; 木村郁夫, Joint work, 第3章 p19-26「腸内細菌の働き解明」
2019

腸内環境改善食物繊維の技術と市場
五十嵐美樹; 須藤明日香; 木村郁夫, Joint work, 第4章 p28-34「腸内細菌叢由来代謝物質とエネルギー代謝」
2019

医学のあゆみ特集
宮本潤基; 木村郁夫, Joint work, Vol.269, No.13, 989-994「短鎖脂肪酸による疾患制御」
2019

CARDIAC PRACTICE
清水秀憲; 大植隆司; 木村郁夫, Joint work, Vol.29, No.4, p23-27「腸内細菌代謝産物と生体機能～循環器・代謝疾患の治療への応用」
2019

実験医学（増刊号）
木村郁夫, Joint work, Vol.37, No.2, p119-126「宿主代謝制御と腸内細菌叢」
2019

ルミナコイド研究
平さつき; 渡辺啓太; 大植隆司; 木村郁夫, Joint work, Vol.22, No.2, p53-62「食物繊維由来腸内細菌代謝物、短鎖脂肪酸と宿主代謝制御」
2018

代謝センシング―健康、食、美容、薬、そして脳の代謝を知る
五十嵐美樹; 須藤明日香; 木村郁夫, Joint work, 第Ⅲ編第17章 p149-156「腸内細菌叢由来代謝物質とエネルギー代謝」
2018

腸内細菌叢を標的にした医薬品・保険機能食品の開発
宮本潤基; 木村郁夫, Joint work, 第3章第一節 p103-110「2型糖尿病治療におけるプロバイオティクスの可能性」
2018

臨床と研究
大植隆司; 平さつき; 木村郁夫, Joint work, Vol.95, No.9, p51-56「プロバイオティクス・プレバイオティクス臨床応用の現状肥満、2型糖尿病」
2018

フードスタイル21
五十嵐美樹; 須藤明日香; 木村郁夫, Joint work, Vol.22, No.8, p55-58「腸内細菌代謝物と抗肥満」
2018

腎臓内科・泌尿器科
中谷明穂; 須藤明日香; 木村郁夫, Joint work, Vol.7, No.6, p564-570「腸内細菌およびその代謝産物による宿主エネルギー代謝制御機構」
2018

食品機能性脂質の基礎と応用
大植隆司; 平さつき; 木村郁夫, Joint work, 第1編第2章 6節 p76-85「短鎖脂肪酸の産生と生理機能調節」
2018

実験医学（増刊号）
木村郁夫; 長谷耕二, Joint work, Vol.36, No.10, p142-146「腸内環境のリポクオリティと疾患制御」
2018

アンチ・エイジング医学
宮本潤基; 中谷明穂; 木村郁夫, Joint work, Vol.14, No.1, p30-35「脂肪酸代謝と腸内環境」
2018

食と医療
渡辺啓太; 平さつき; 木村郁夫, Joint work, Vol.4, p30-37「短鎖脂肪酸の産生・代謝と生理作用」
2018

Modern Physician
渡辺啓太; 宮本潤基; 木村郁夫, Joint work, Vol.38, No.2, p158-161「肥満と腸内細菌叢」
2018

医学のあゆみ特集号
木村郁夫, Joint work, Vol.264, No.1, p39-45「腸内細菌と肥満－宿主エネルギー代謝制御における腸内細菌の役割」
2018

Awards

Apr. 2022
令和4年度文部科学大臣表彰科学技術賞
長谷耕二, 木村郁夫

Dec. 2020
第25回安藤百福賞「優秀賞」
木村郁夫

Oct. 2017
第1回バイオインダストリー奨励賞
木村郁夫

Dec. 2016
第18回腸内細菌学会研究奨励賞
木村郁夫

Dec. 2016
第15回杉田玄白賞
木村郁夫

Apr. 2016
平成28年度文部科学大臣表彰若手科学者賞
木村郁夫

Apr. 2014
2014年度日本内分泌学会若手研究奨励賞
木村郁夫

Jan. 2014
2013年度日本薬学会近畿支部奨励賞
木村郁夫

Feb. 2010
第39回日本心脈管作動物質学会研究奨励賞
木村郁夫

External funds: Kakenhi

栄養環境の変化を認識する短鎖脂肪酸受容体を介した神経・免疫・代謝制御
Grant-in-Aid for Scientific Research (A)
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Kyoto University
木村郁夫
From 05 Apr. 2021, To 31 Mar. 2025, Granted
短鎖脂肪酸;GPCR;脂肪酸受容体;腸内細菌
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04862/

Molecular nutritional signaling via MCFA and ketone body receptors
Grant-in-Aid for Challenging Research (Exploratory)
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Tokyo University of Agriculture and Technology
Ikuo Kimura
From 29 Jun. 2018, To 31 Mar. 2020, Project Closed
中鎖脂肪酸;ケトン体;GPR84;GPR109A;GPR41;GPR43
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19731/

Pathophysiological functions via membrane progesterone receptors
Grant-in-Aid for Scientific Research (B)
Basic Section 44040:Morphology and anatomical structure-related
Kyoto University;Tokyo University of Agriculture and Technology
Kimura Ikuo
From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
プロゲステロン;GPCR;性ステロイドホルモン受容体;MAPR;mPR
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02472/

脂肪酸代謝物と脂肪酸受容体群による包括的エネルギー代謝ネットワークの解明
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Biological Sciences
Tokyo University of Agriculture and Technology
木村郁夫
From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
多価不飽和脂肪酸;腸内細菌;脂肪酸受容体;GPR40;GPR120;オメガ6脂肪酸;オメガ3脂肪酸;長鎖脂肪酸;中鎖脂肪酸;オメガ脂肪酸;肥満
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01355/

Dietary obesity and metabolic syndrome: Host energy regulation via short-chain fatty acid receptors by gut microbiota
Grant-in-Aid for Young Scientists (A)
Tokyo University of Agriculture and Technology
Ikuo Kimura
From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
腸内細菌;食物繊維;短鎖脂肪酸;脂肪酸受容体;肥満;生活習慣病;GPR41;GPR43;GPCR;短鎖脂肪酸受容体;食品薬理;薬理栄養
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05344/

Analyses of the immune cells involving intestinal inflammation and its application for development of foods with intestinal barrier-protecting activity
Grant-in-Aid for Scientific Research (B)
Hiroshima University
TANABE Soichi
From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
Caco-2;CD40;colitis;tight junction;baｃterial metabolite;lactic acid bacteria;bidifobacteria;intestinal barrier;commensal bacteria;bacterial metabolite;HYA;Th17;bifidobacteria;hypoxia
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25292074/

Energy regulation by dietary gut microbial metabolites via short-chain fatty acids receptors
Grant-in-Aid for Scientific Research (C)
Tokyo University of Agriculture and Technology;Kyoto University
Kimura IKUO
From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
脂肪酸受容体;脂肪組織;ノックアウトマウス;GPCR;短鎖脂肪酸;腸内細菌
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590077/

Mechanism of energy homeostasis maintenance via short-chain fatty acids receptor(GPR41), dietary energy sensor
Grant-in-Aid for Young Scientists (B)
Kyoto University
Ikuo KIMURA
From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
脂肪酸受容体;交感神経;ノックアウトマウス;GPCR;短鎖脂肪酸
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790065/

New genome medicine and drug discovery based on the comprehensive transcriptome analysis
Grant-in-Aid for Scientific Research (S)
Kyoto University
Gozoh TSUJIMOTO
From 01 Apr. 2007, To 31 Mar. 2012, Project Closed
包括的トランスクリプトーム解析;マイクロRNA;ネットワーク解析;超高感度DNAチップ;発現プロファイル;食道がん;乳がん;バイオマーカー;miRNA;上皮細胞;がん;分化;microRNA;トランスクリプトーム;DNAチップ;バイオインフォマッティックス;RNA;疾患動物モデル;バイオインフォマティックス
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19109001/

External funds: others

メタボリックシンドローム予防を目的とした革新的な機能性食品素材（米ぬか発酵代謝物）の研究開発 (2021年度分)
経済産業省, 中小企業経営支援等対策費補助金
From 01 Apr. 2021, To 31 Mar. 2022
分担

Last Updated :2023/05/27

Education

Teaching subject(s)

From 01 Apr. 2023, To 31 Mar. 2024
Introduction to Biology and Life Science
N484, Spring, Institute for Liberal Arts and Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Research Proposal Writing Practice B
8403, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Research Proposal Writing Practice A
8402, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Pharmaceutical Laboratory Coaching Practice A
8301, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Laboratory Practice in Basic Physiological Chemistry
4206, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Industry-academia Collaborative Internship A
8305, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
International Skills Practice A
8303, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Pharmaceutical Laboratory Coaching Practice B
8302, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Course in Immunology and Human Disorders
1031, Spring, Graduate School of Biostudies, 1

From 01 Apr. 2023, To 31 Mar. 2024
Research Training(Molecular Endocrinology)
D172, Year-long, Faculty of Pharmaceutical Sciences, 10

From 01 Apr. 2023, To 31 Mar. 2024
Research Training(Molecular Neurobiology)
D143, Year-long, Faculty of Pharmaceutical Sciences, 10

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar D
2009, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar D
2009, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar C
2008, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar A
2006, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar A
2006, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar C
2008, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar B
2007, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar B
2007, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Research in Basic Molecular Neurobiology
3212, Year-long, Graduate School of Pharmaceutical Sciences, 4

From 01 Apr. 2023, To 31 Mar. 2024
Medicinal Frontier Science Research B
8407, Year-long, Graduate School of Pharmaceutical Sciences, 4

From 01 Apr. 2023, To 31 Mar. 2024
Medicinal Frontier Science Research A
8406, Year-long, Graduate School of Pharmaceutical Sciences, 4

From 01 Apr. 2023, To 31 Mar. 2024
Research Training(Molecular Neurobiology)
8143, Year-long, Faculty of Pharmaceutical Sciences, 6

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Experiments in Systemic Life Sciences
5013, Fall, Graduate School of Biostudies, 4

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Experiments in Systemic Life Sciences
5013, Spring, Graduate School of Biostudies, 4

From 01 Apr. 2023, To 31 Mar. 2024
Biological Chemistry III (Molecular biology)
C214, Fall, Faculty of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Biological Chemistry 3 (Molecular biology)
A214, Fall, Faculty of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Critical Reading of Scientific Papers B
8405, Year-long, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Critical Reading of Scientific Papers A
8404, Year-long, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Introduction to Pharmaceutical Biochemistry
8103, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Basic Laboratory Techniques in Biological Chemistry
1207, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Basic Laboratory Techniques in Biological Chemistry
1207, Fall, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Introduction to Modern Life Sciences for Drug Discovery
1027, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
２１ＣＯＥ化学講義３（理）
8001, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Introduction to Pharmaceutical Sciences
6002, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Seminar in Basic Molecular Neurobiology
2312, Year-long, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar C
2008, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar B
2007, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Biological Chemistry III (Molecular biology)
C214, Fall, Faculty of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Pharmaceutical Laboratory Coaching Practice A
8301, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2022, To 31 Mar. 2023
Introduction to Pharmaceutical Biochemistry
8103, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Seminar in Basic Molecular Neurobiology
2312, Year-long, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Experiments in Systemic Life Sciences
5013, Spring, Graduate School of Biostudies, 4

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Experiments in Systemic Life Sciences
5013, Fall, Graduate School of Biostudies, 4

From 01 Apr. 2022, To 31 Mar. 2023
Basic Laboratory Techniques in Biological Chemistry
1207, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
２１ＣＯＥ化学講義３（理）
8001, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Research Training(Molecular Neurobiology)
8143, Year-long, Faculty of Pharmaceutical Sciences, 6

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar A
2006, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Introduction to Modern Life Sciences for Drug Discovery
1027, Spring, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Laboratory Practice in Basic Physiological Chemistry
4206, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Critical Reading of Scientific Papers A
8404, Year-long, Graduate School of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Pharmaceutical Biochemistry B
8206, Spring, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar D
2009, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Research in Basic Molecular Neurobiology
3212, Year-long, Graduate School of Pharmaceutical Sciences, 4

From 01 Apr. 2022, To 31 Mar. 2023
Medical Frontier Science Research A
8406, Year-long, Graduate School of Pharmaceutical Sciences, 4

From 01 Apr. 2022, To 31 Mar. 2023
Research Training(Molecular Neurobiology)
D143, Year-long, Faculty of Pharmaceutical Sciences, 10

From 01 Apr. 2022, To 31 Mar. 2023
Biological Chemistry 3 (Molecular biology)
A214, Fall, Faculty of Pharmaceutical Sciences, 2

From 01 Apr. 2022, To 31 Mar. 2023
Research Proposal Writing Practice A
8402, Year-long, Graduate School of Pharmaceutical Sciences, 1

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar C
2008, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar B
2007, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar D
2009, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar A
2006, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Course in Immunology and Human Disorders
1031, Spring, Graduate School of Biostudies, 1

ゲノム創薬科学／薬理ゲノミクス実習

基礎化学実習

From Apr. 2011, To Mar. 2012
薬学専門実習III
Fall, 薬学部

From Apr. 2011, To Mar. 2012
薬学専門実習４
Fall, 薬学部

From Apr. 2012, To Mar. 2013
Pharmaceutical Laboratory IV: Pharmaceutics and Pharmacology
Fall, 薬学部

From Apr. 2012, To Mar. 2013
Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
Fall, 薬学部

From Apr. 2013, To Mar. 2014
Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
Fall, 薬学部

From Apr. 2021, To Mar. 2022
Introduction to Modern Life Sciences for Drug Discovery
Spring, 薬学研究科

From Apr. 2021, To Mar. 2022
Laboratory Practice in Basic Physiological Chemistry
Year-long, 薬学研究科

From Apr. 2021, To Mar. 2022
Basic Laboratory Techniques in Biological Chemistry
Spring, 薬学研究科

From Apr. 2021, To Mar. 2022
Basic Laboratory Techniques in Biological Chemistry
Fall, 薬学研究科

From Apr. 2021, To Mar. 2022
Research in Basic Molecular Neurobiology
Year-long, 薬学研究科

From Apr. 2021, To Mar. 2022
Seminar in Basic Molecular Neurobiology
Year-long, 薬学研究科

From Apr. 2021, To Mar. 2022
Research Training(Molecular Neurobiology)
Year-long, 薬学部

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Advanced Experiments in Systemic Life Sciences
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Advanced Experiments in Systemic Life Sciences
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Biological Chemistry III (Molecular biology)
Fall, 薬学部

From Apr. 2021, To Mar. 2022
Biological Chemistry 3 (Molecular biology)
Fall, 薬学部

From Apr. 2021, To Mar. 2022
Frontiers of Biology
Spring, 全学共通科目

From Apr. 2021, To Mar. 2022
Advanced Course in Immunology and Human Disorders
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Basic Laboratory Techniques in Pharmaceutical Sciences
Spring, 薬学研究科

Participation in PhD Defense

気道炎症における2型自然リンパ球の維持及び活性化に対する局所インターロイキン7の機能に関する研究
TAKAMI DAICHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner
23 Mar. 2023

アレルギー性気道炎症におけるアンドロゲンによる２型ヘルパーT細胞抑制機構の解析
EJIMA AKI, Graduate School of Biostudies, Sub-chief Examiner
23 Mar. 2023

臨床ビッグデータ解析と薬理学的実験の統合による腱障害予防法の探索
FURUTA HARUKA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner
23 Mar. 2023

EphA2によるグリオブラストーマの細胞増殖制御機構に関する研究
TAMURA YUHO, Graduate School of Pharmaceutical Sciences, Chief Examiner
26 Sep. 2022

グルコース飢餓におけるアミノ酸トランスポーターxCTを介したEphA2リガンド非依存的シグナルの制御
TERAMOTO KOJI, Graduate School of Pharmaceutical Sciences, Chief Examiner
23 Mar. 2022

妊娠における母体肝臓リモデリング機構の解析
KOZUKI SATOSHI, Graduate School of Biostudies, Sub-chief Examiner
23 Mar. 2022

Part-time lecturer

From 01 Oct. 2021, To 31 Mar. 2022
奈良女子大学

Last Updated :2023/05/27

Administration

School management (title, position)

From 01 Apr. 2023, To 31 Mar. 2025
教育制度委員会教育質保証専門委員会委員

From 01 Apr. 2023, To 31 Mar. 2025
教育制度委員会委員

Faculty management (title, position)

From 01 Apr. 2022
SPFマウス実験室運営委員会

From 01 Apr. 2022
教務委員会

From 01 Apr. 2022, To 31 Mar. 2023
高次生命科学専攻長

From 01 Apr. 2021, To 31 Mar. 2022
高次生命科学副専攻長

From 01 Apr. 2021
情報発信・ホームページ委員会　委員

From 01 Apr. 2021, To 31 Mar. 2023
改善委員会　委員

From 01 Apr. 2021, To 31 Mar. 2023
同窓会

From 01 Apr. 2021, To 31 Mar. 2022
男女共同参画推進アクションプラン推進委員会　委員

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Kimura, Ikuo

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External funds: Kakenhi

External funds: others

Education

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Participation in PhD Defense

Part-time lecturer

Administration

School management (title, position)

Faculty management (title, position)