Basic Information

Academic Degree

• 生物化学(University of Tokyo)
• 分子生物学(Nagoya University)

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0002-4220-6408

• J-Global ID

  201701017039840970

researchmap URL

• https://researchmap.jp/7000019526

Research

Research Topics, Overview of the research

• Research Topics

  Developing nanoparticles for their application for cancer therapy

• Overview of the research

  We are developing　mesoporous　silica　nanoparticles　that for use in cancer therapy.　Synthesis and characterization of these nanoparticles are ongoing. To examine the efficacy of anticancer drug loaded nanoparticles, we are using animal models.

Research Areas

• Life sciences, Tumor biology

Papers

• Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape

  Miguel Gisbert-Garzaran; Daniel Lozano; Kotaro Matsumoto; Aoi Komatsu; Miguel Manzano; Fuyuhiko Tamanoi; Maria Vallet-Regi

  ACS Applied Materials and Interfaces, 03 Mar. 2021

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• Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy.

  Mathilde Laird; Kotaro Matsumoto; Yuya Higashi; Aoi Komatsu; Art Raitano; Kendall Morrison; Minoru Suzuki; Fuyuhiko Tamanoi

  Nanoscale advances, 02 May 2023

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• Tumor Accumulation of PIP-Based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model

  Yuya Higashi; Shuji Ikeda; Kotaro Matsumoto; Shinsuke Satoh; Aoi Komatsu; Hiroshi Sugiyama; Fuyuhiko Tamanoi

  Cancers, 14 Feb. 2022

  
• The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.

  Aoi Komatsu; Kotaro Matsumoto; Yuki Yoshimatsu; Yooksil Sin; Arisa Kubota; Tomoki Saito; Ayaka Mizumoto; Shinya Ohashi; Manabu Muto; Rei Noguchi; Tadashi Kondo; Fuyuhiko Tamanoi

  Cells, 01 Oct. 2021

  
• PROCESSING AND FATTY-ACID ACYLATION OF RAS PROTEINS

  F TAMANOI; A FUJIYAMA

  JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, Peer-reviewed

  
• DIFFERENTIAL ACTIVATION OF YEAST ADENYLATE-CYCLASE BY WILD-TYPE AND MUTANT RAS PROTEINS

  D BROEK; N SAMIY; O FASANO; A FUJIYAMA; F TAMANOI; J NORTHUP; M WIGLER

  CELL, 1985, Peer-reviewed

  
• Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

  Yuya Higashi; Kotaro Matsumoto; Hiroyuki Saitoh; Ayumi Shiro; Yue Ma; Mathilde Laird; Shanmugavel Chinnathambi; Albane Birault; Tan Le Hoang Doan; Ryo Yasuda; Toshiki Tajima; Tetsuya Kawachi; Fuyuhiko Tamanoi

  Scientific Reports, Dec. 2021

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• Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

  Fuyuhiko Tamanoi; Shanmugavel Chinnathambi; Mathilde Laird; Aoi Komatsu; Albane Birault; Takushi Takata; Tan Le-Hoang Doan; Ngoc Xuan Dat Mai; Arthur Raitano; Kendall Morrison; Minoru Suzuki; Kotaro Matsumoto

  International Journal of Molecular Sciences, 24 Feb. 2021, Peer-reviewed, Lead author

  
• Facile synthesis of biodegradable mesoporous functionalized-organosilica nanoparticles for enhancing the anti-cancer efficiency of cordycepin

  Ngoc Xuan Dat Mai; Uyen-Chi Nguyen Le; Linh Ho Thuy Nguyen; Hanh Thi Kieu Ta; Ha Van Nguyen; Tri Minh Le; Thang Bach Phan; Lien-Thuong Thi Nguyen; Fuyuhiko Tamanoi; Tan Le Hoang Doan

  Microporous and Mesoporous Materials, Feb. 2021, Peer-reviewed

  
• Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

  Shanmugavel Chinnathambi; Fuyuhiko Tamanoi

  Pharmaceutics, 18 Sep. 2020

  
• Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy.

  Fuyuhiko Tamanoi; Kotaro Matsumoto; Tan Le Hoang Doan; Ayumi Shiro; Hiroyuki Saitoh

  Nanomaterials (Basel, Switzerland), 09 Jul. 2020, Peer-reviewed, Lead author

  
• Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle-Based Anticancer Drug.

  Ngoc Xuan Dat Mai; Albane Birault; Kotaro Matsumoto; Hanh Kieu Thi Ta; Soontaree Grace Intasa-Ard; Kendall Morrison; Phan Bach Thang; Tan Le Hoang Doan; Fuyuhiko Tamanoi

  ChemMedChem, 03 Apr. 2020, Peer-reviewed

  
• Recent excitements in the study of the CAM assay.

  Fuyuhiko Tamanoi

  The Enzymes, Oct. 2019, Peer-reviewed

  
• Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy.

  Kotaro Matsumoto; Hiroyuki Saitoh; Tan Le Hoang Doan; Ayumi Shiro; Keigo Nakai; Aoi Komatsu; Masahiko Tsujimoto; Ryo Yasuda; Tetsuya Kawachi; Toshiki Tajima; Fuyuhiko Tamanoi

  Scientific reports, 30 Sep. 2019, Peer-reviewed

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• Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues.

  Aoi Komatsu; Kotaro Matsumoto; Tomoki Saito; Manabu Muto; Fuyuhiko Tamanoi

  Cells, 10 May 2019, Peer-reviewed

  
• Relationship between the glutathione-responsive degradability of thiol-organosilica nanoparticles and the chemical structures

  Doura Tomoshiro; Nishio Tadashi; Tamanoi Fuyuhiko; Nakamura Michihiro

  JOURNAL OF MATERIALS RESEARCH, 15 Apr. 2019, Peer-reviewed

  
• がんの個別化医療を切り拓く鶏卵モデル

  玉野井 冬彦; 遠藤 良夫; 宇都 義浩; 楠橋 由貴; 二若 真菜; 松本 光太郎

  実験医学, Jan. 2019, Peer-reviewed

  
• Biodegradability of Disulfide-Organosilica Nanoparticles Evaluated by Soft X-ray Photoelectron Spectroscopy: Cancer Therapy Implications

  Harutaka Mekaru; Akitaka Yoshigoe; Michihiro Nakamura; Tomohiro Doura; Fuyuhiko Tamanoi

  ACS APPLIED NANO MATERIALS, Jan. 2019, Peer-reviewed

  
• Miniaturization of thiol-organosilica nanoparticles induced by an anionic surfactant

  Tomohiro Doura; Fuyuhiko Tamanoi; Michihiro Nakamura

  Journal of Colloid and Interface Science, 15 Sep. 2018, Peer-reviewed

  
• Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer.

  Binh Thanh Vu; Sophia Allaf Shahin; Jonas Croissant; Yevhen Fatieiev; Kotaro Matsumoto; Tan Le-Hoang Doan; Tammy Yik; Shirleen Simargi; Altagracia Conteras; Laura Ratliff; Chiara Mauriello Jimenez; Laurence Raehm; Niveen Khashab; Jean-Olivier Durand; Carlotta Glackin; Fuyuhiko Tamanoi

  Scientific reports, 04 Jun. 2018, Peer-reviewed

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• Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer.

  Shahin SA; Wang R; Simargi SI; Contreras A; Parra Echavarria L; Qu L; Wen W; Dellinger T; Unternaehrer J; Tamanoi F; Zink JI; Glackin CA

  Nanomedicine : nanotechnology, biology, and medicine, Apr. 2018, Peer-reviewed

  
• Isolation and characterization of the primary epithelial breast cancer cells and the adjacent normal epithelial cells from Iranian women's breast cancer tumors.

  Faridi N; Bathaie SZ; Abroun S; Farzaneh P; Karbasian H; Tamanoi F; Mohagheghi MA

  Cytotechnology, Apr. 2018, Peer-reviewed

  
• An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

  Jeffrey J. Heard; Ivy Phung; Mark I. Potes; Fuyuhiko Tamanoi

  BMC Cancer, 10 Jan. 2018, Peer-reviewed

  
• Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models.

  Le Hoang; Doan T; Mai NXD; Matsumoto K; Tamanoi F

  The Enzymes, 2018, Peer-reviewed

  
• Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application.

  Vallet-Regi M; Tamanoi F

  The Enzymes, 2018, Peer-reviewed

  
• Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model.

  Matsumoto K; Le Hoang; Doan T; Mai NXD; Nakai K; Komatsu A; Tamanoi F

  The Enzymes, 2018, Peer-reviewed

  
• A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group

  Ayumi Tanaka; Mohamed O. Radwan; Akiyuki Hamasaki; Asumi Ejima; Emiko Obata; Ryoko Koga; Hiroshi Tateishi; Yoshinari Okamoto; Mikako Fujita; Mitsuyoshi Nakao; Kazuo Umezawa; Fuyuhiko Tamanoi; Masami Otsuka

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2017, Peer-reviewed

  
• Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models

  Cai M. Roberts; Sophia Allaf Shahin; Wei Wen; James B. Finlay; Juyao Dong; Ruining Wang; Thanh H. Dellinger; Jeffrey I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Apr. 2017, Peer-reviewed

  
• Exploiting Enzyme Alterations in Cancer for Drug Activation, Drug Delivery, and Nanotherapy

  Joel Y. Hayashi; Fuyuhiko Tamanoi

  Enzymes, 2017, Peer-reviewed

  
• Exploiting Enzyme Alterations in Cancer for Drug Activation, Drug Delivery, and Nanotherapy.

  Hayashi JY; Tamanoi F

  The Enzymes, 2017, Peer-reviewed

  
• Mevalonate Pathway and Human Cancers

  Seyedeh Zahra Bathaie; Mahboobeh Ashrafi; Mahshid Azizian; Fuyuhiko Tamanoi

  CURRENT MOLECULAR PHARMACOLOGY, 2017, Peer-reviewed

  
• Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

  Jonas G. Croissant; Yevhen Fatieiev; Khachatur Julfakyan; Jie Lu; Abdul-Hamid Emwas; Dalaver H. Anjum; Haneen Omar; Fuyuhiko Tamanoi; Jeffrey I. Zink; Niveen M. Khashab

  CHEMISTRY-A EUROPEAN JOURNAL, Oct. 2016, Peer-reviewed

  
• Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells

  Jonas G. Croissant; Yevhen Fatieiev; Haneen Omar; Dalaver H. Anjum; Andrey Gurinov; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink; Niveen M. Khashab

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2016, Peer-reviewed

  
• Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

  Jonas G. Croissant; Dingyuan Zhang; Shahad Alsaiari; Jie Lu; Lin Deng; Fuyuhiko Tamanoi; Abdulaziz M. AlMalik; Jeffrey I. Zink; Niveen M. Khashab

  JOURNAL OF CONTROLLED RELEASE, May 2016, Peer-reviewed

  
• Rheb-CADシグナル伝達経路によるピリミジンヌクレオチド生合成促進機構

  下野 航; 佐藤 龍洋; 玉野井 冬彦; 服部 成介

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• TORの実像に迫れ! Rheb-mTORC1によるピリミジンヌクレオチド生合成制御機構の解析

  佐藤 龍洋; 玉野井 冬彦; 服部 成介

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

  Harutaka Mekaru; Jie Lu; Fuyuhiko Tamanoi

  ADVANCED DRUG DELIVERY REVIEWS, Dec. 2015, Peer-reviewed

  
• Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden

  James Finlay; Cai M. Roberts; Juyao Dong; Jeffrey I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Oct. 2015, Peer-reviewed

  
• Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells

  Jie Lu; Kohei Yoshimura; Koichi Goto; Craig Lee; Ken Hamura; Ohyun Kwon; Fuyuhiko Tamanoi

  PLOS ONE, Sep. 2015, Peer-reviewed

  
• Significance of filamin A in mTORC2 function in glioblastoma

  Naphat Chantaravisoot; Piriya Wongkongkathep; Joseph A. Loo; Paul S. Mischel; Fuyuhiko Tamanoi

  MOLECULAR CANCER, Jul. 2015, Peer-reviewed

  
• Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

  Fariborz Mortazavi; Jie Lu; Ryan Phan; Michael Lewis; Kenny Trinidad; Amir Aljilani; Gholamhossein Pezeshkpour; Fuyuhiko Tamanoi

  BMC CANCER, May 2015, Peer-reviewed

  
• Functional Nanovalves on Protein-Coated Nanoparticles for In vitro and In vivo Controlled Drug Delivery

  Angela A. Hwang; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink

  SMALL, Jan. 2015, Peer-reviewed

  
• Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP-and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

  Tatsuhiro Sato; Hitomi Akasu; Wataru Shimono; Chisa Matsu; Yuki Fujiwara; Yoshio Shibagaki; Jeffrey J. Heard; Fuyuhiko Tamanoi; Seisuke Hattori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2015, Peer-reviewed

  
• Hybrid Mesoporous Silica Nanoparticles with pH-Operated and Complementary H-Bonding Caps as an Autonomous Drug-Delivery System

  Christophe Theron; Audrey Gallud; Carole Carcel; Magali Gary-Bobo; Marie Maynadier; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink; Michel Wong Chi Man

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2014, Peer-reviewed

  
• Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter

  Akio Nakashima; Shinji Kamada; Fuyuhiko Tamanoi; Ushio Kikkawa

  BIOLOGY OPEN, Jun. 2014, Peer-reviewed

  
• Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves

  Jonas Croissant; Arnaud Chaix; Olivier Mongin; Miao Wang; Sebastien Clement; Laurence Raehm; Jean-Olivier Durand; Vincent Hugues; Mireille Blanchard-Desce; Marie Maynadier; Audrey Gallud; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Daniel P. Ferris; Derrick Tarn; Jeffrey I. Zink

  SMALL, May 2014, Peer-reviewed

  
• ファルネシルトランスフェラーゼの特異的阻害を目的とした亜鉛キレーターの設計及び合成

  田中 亜友美; 岡本 良成; 藤田 美歌子; 梅澤 和夫; 玉野井 冬彦; 大塚 雅巳

  日本薬学会年会要旨集, Mar. 2014, Peer-reviewed

  
• Silica-Based Nanoporous Materials

  Eunshil Choi; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink

  ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, Mar. 2014, Peer-reviewed

  
• Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*

  Kimberly Coffman; Bing Yang; Jie Lu; Ashley L. Tetlow; Emelia Pelliccio; Shan Lu; Da-Chuan Guo; Chun Tang; Meng-Qiu Dong; Fuyuhiko Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2014, Peer-reviewed

  
• Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

  Jonas Croissant; Marie Maynadier; Audrey Gallud; Harmel Peindy N'Dongo; Jeff L. Nyalosaso; Gaelle Derrien; Clarence Charnay; Jean-Olivier Durand; Laurence Raehm; Francoise Serein-Spirau; Nathalie Cheminet; Thibaut Jarrosson; Olivier Mongin; Mireille Blanchard-Desce; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Derrick Tarn; Tania M. Guardado-Alvarez; Jeffrey I. Zink

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Dec. 2013, Peer-reviewed

  
• De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.

  David Akhavan; Alexandra L Pourzia; Alex A Nourian; Kevin J Williams; David Nathanson; Ivan Babic; Genaro R Villa; Kazuhiro Tanaka; Ali Nael; Huijun Yang; Julie Dang; Harry V Vinters; William H Yong; Mitchell Flagg; Fuyuhiko Tamanoi; Takashi Sasayama; C David James; Harley I Kornblum; Tim F Cloughesy; Webster K Cavenee; Steven J Bensinger; Paul S Mischel

  Cancer discovery, May 2013, Peer-reviewed

  
• In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

  Drazen B. Zimonjic; Lai N. Chan; Veenu Tripathi; Jie Lu; Ohyun Kwon; Nicholas C. Popescu; Douglas R. Lowy; Fuyuhiko Tamanoi

  BMC CANCER, Apr. 2013, Peer-reviewed

  
• Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

  Rolando E. Yanes; Derrick Tarn; Angela A. Hwang; Daniel P. Ferris; Sean P. Sherman; Courtney R. Thomas; Jie Lu; April D. Pyle; Jeffrey I. Zink; Fuyuhiko Tamanoi

  SMALL, Mar. 2013, Peer-reviewed

  
• A two-hybrid approach to identify inhibitors of the ras-raf interaction

  Vladimir Khazak; Susanne Eyrisch; Juran Kato; Fuyuhiko Tamanoi; Erica A. Golemis

  Enzymes, 2013, Peer-reviewed

  
• Tuning the Biodegradability of Silicon Nanoparticles for Drug Delivery

  Nick K. Hon; Zory Shaposhnik; Eric D. Diebold; Fuyuhiko Tamanoi; Bahram Jalali

  SURFACE TREATMENTS FOR BIOMEDICAL APPLICATIONS 3, 2013, Peer-reviewed

  
• Tailoring the biodegradability of porous silicon nanoparticles

  Nick K. Hon; Zory Shaposhnik; Eric D. Diebold; Fuyuhiko Tamanoi; Bahram Jalali

  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Dec. 2012, Peer-reviewed

  
• Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase

  Akio Nakashima; Yoko Otsubo; Akira Yamashita; Tatsuhiro Sato; Masayuki Yamamoto; Fuyuhiko Tamanoi

  JOURNAL OF CELL SCIENCE, Dec. 2012, Peer-reviewed

  
• PAK1 Kinase Promotes Cell Motility and Invasiveness through CRK-II Serine Phosphorylation in Non-Small Cell Lung Cancer Cells

  Matthew Rettig; Kenny Trinidad; G. Pezeshkpour; Patrick Frost; Sherven Sharma; Farhad Moatamed; Fuyuhiko Tamanoi; Fariborz Mortazavi

  PLOS ONE, Jul. 2012, Peer-reviewed

  
• Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

  Yanes RE; Tamanoi F

  Therapeutic delivery, Mar. 2012, Peer-reviewed

  
• In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification

  Jie Lu; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Feb. 2012, Peer-reviewed

  
• Continuous spectroscopic measurements of photo-stimulated release of molecules by nanomachines in a single living cell

  Yuen A. Lau; Bryana L. Henderson; Jie Lu; Daniel P. Ferris; Fuyuhiko Tamanoi; Jeffrey I. Zink

  NANOSCALE, 2012, Peer-reviewed

  
• Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I

  Lai N. Chan; Hannah D. G. Fiji; Masaru Watanabe; Ohyun Kwon; Fuyuhiko Tamanoi

  PLOS ONE, Oct. 2011, Peer-reviewed

  
• Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells

  Daniel P. Ferris; Jie Lu; Chris Gothard; Rolando Yanes; Courtney R. Thomas; John-Carl Olsen; J. Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I. Zink

  SMALL, Jul. 2011, Peer-reviewed

  
• pH-Operated Mechanized Porous Silicon Nanoparticles

  Min Xue; Xing Zhong; Zory Shaposhnik; Yongquan Qu; Fuyuhiko Tamanoi; Xiangfeng Duan; Jeffrey I. Zink

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2011, Peer-reviewed

  
• Ras signaling in yeast.

  Tamanoi F

  Genes & cancer, Mar. 2011, Peer-reviewed

  
• Activating mutations of TOR (target of rapamycin)

  Molly Hardt; Naphat Chantaravisoot; Fuyuhiko Tamanoi

  GENES TO CELLS, Feb. 2011, Peer-reviewed

  
• Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves

  Huan Meng; Min Xue; Tian Xia; Yan-Li Zhao; Fuyuhiko Tamanoi; J. Fraser Stoddart; Jeffrey I. Zink; Andre E. Nel

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2010, Peer-reviewed

  
• Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

  Jie Lu; Monty Liong; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi

  SMALL, Aug. 2010, Peer-reviewed

  
• Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells

  Christopher Hom; Jie Lu; Monty Liong; Hanzhi Luo; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi

  SMALL, Jun. 2010, Peer-reviewed

  
• Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy

  Huaidong Jiang; Changyong Song; Chien-Chun Chen; Rui Xu; Kevin S. Raines; Benjamin P. Fahimian; Chien-Hung Lu; Ting-Kuo Lee; Akio Nakashima; Jun Urano; Tetsuya Ishikawa; Fuyuhiko Tamanoi; Jianwei Miao

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2010, Peer-reviewed

  
• Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

  T. Sato; A. Nakashima; L. Guo; K. Coffman; F. Tamanoi

  ONCOGENE, May 2010, Peer-reviewed

  
• Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin

  Akio Nakashima; Tatsuhiro Sato; Fuyuhiko Tamanoi

  JOURNAL OF CELL SCIENCE, Mar. 2010, Peer-reviewed

  
• Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

  A. B. Hanker; N. Mitin; R. S. Wilder; E. P. Henske; F. Tamanoi; A. D. Cox; C. J. Der

  ONCOGENE, Jan. 2010, Peer-reviewed

  
• Rheb G-Proteins and the Activation of mTORC1.

  Parmar N; Tamanoi F

  The Enzymes, 2010, Peer-reviewed

  
• [Rheb-mTOR signaling pathway involved in tumor formation].

  Sato T; Nakashima A; Tamanoi F

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jan. 2010, Peer-reviewed

  
• A novel approach to tag and identify geranylgeranylated proteins

  Lai N. Chan; Courtenay Hart; Lea Guo; Tamara Nyberg; Brandon S. J. Davies; Loren G. Fong; Stephen G. Young; Brian J. Agnew; Fuyuhiko Tamanoi

  ELECTROPHORESIS, Oct. 2009, Peer-reviewed

  
• mTOR活性変異体の同定およびRheb-mTORシグナル伝達の解析

  佐藤 龍洋; 服部 成介; 玉野井 冬彦

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• Construction of a model cell line for the assay of MDR1 (Multi Drug Resistance gene-1) substrates/inhibitors using HeLa cells

  Fumihiko Kugawa; T. Suzuki; M. Miyata; K. Tomono; F. Tamanoi

  Pharmazie, May 2009, Peer-reviewed

  
• In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

  Jie Lu; Lai Chan; Hannah D. G. Fiji; Russell Dahl; Ohyun Kwon; Fuyuhiko Tamanoi

  MOLECULAR CANCER THERAPEUTICS, May 2009, Peer-reviewed

  
• Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

  Tatsuhiro Sato; Akio Nakashima; Lea Guo; Fuyuhiko Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2009, Peer-reviewed

  
• The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner

  Jun Zhou; Chantal Chanel Vos; Ada Gjyrezi; Minoru Yoshida; Fadlo R. Khuri; Fuyuhiko Tamanoi; Paraskevi Giannakakou

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2009, Peer-reviewed

  
• Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

  Brandon S. J. Davies; Shao H. Yang; Emily Farber; Roger Lee; Suzanne B. Buck; Douglas A. Andres; H. Peter Spielmann; Brian J. Agnew; Fuyuhiko Tamanoi; Loren G. Fong; Stephen G. Young

  JOURNAL OF LIPID RESEARCH, Jan. 2009, Peer-reviewed

  
• Silica nanoparticles as a delivery system for nucleic acid-based reagents

  Christopher Hom; Jie Lu; Fuyuhiko Tamanoi

  JOURNAL OF MATERIALS CHEMISTRY, 2009, Peer-reviewed

  
• Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery

  Yaroslav Klichko; Monty Liong; Eunshil Choi; Sarah Angelos; Andre E. Nel; J. Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I. Zink

  JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Jan. 2009, Peer-reviewed

  
• 栄養・代謝・成長から高次機能へ TOR経路研究の最前線 Rheb small G proteinによるmTORの活性化機構

  佐藤 龍洋; 玉野井 冬彦

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27

  John D. Short; Kevin D. Houston; Ruhee Dere; Sheng-Li Cai; Jinhee Kim; Charles L. Johnson; Russell R. Broaddus; Jianjun Shen; Susie Miyamoto; Fuyuhiko Tamanoi; David Kwiatkowski; Gordon B. Mills; Cheryl Lyn Walker

  CANCER RESEARCH, Aug. 2008, Peer-reviewed

  
• Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery

  Monty Liong; Jie Lu; Michael Kovochich; Tian Xia; Stefan G. Ruehm; Andre E. Nel; Fuyuhiko Tamanoi; Jeffrey I. Zink

  ACS NANO, May 2008, Peer-reviewed

  
• Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds

  Masaru Watanabe; Hannah D. G. Fiji; Lea Guo; Lai Chan; Sape S. Kinderman; Dennis J. Slamon; Ohyun Kwon; Fuyuhiko Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2008, Peer-reviewed

  
• Light-activated nanoimpeller-controlled drug release in cancer cells

  Jie Lu; Eunshil Choi; Fuyuhiko Tamanoi; Jeffrey I. Zink

  SMALL, Apr. 2008, Peer-reviewed

  
• Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control

  Kyoko Ikeda; Susumu. Morigasaki; Hisashi Tatebe; Fuyuhiko Tamanoi; Kazuhiro Shiozaki; These authors contributed equally to this wor

  Cell Cycle, Feb. 2008, Peer-reviewed

  
• Characterization of the Rheb-mTOR signaling pathway in mammalian cells: Constitutive active mutants of Rheb and mTOR

  Tatsuhiro Sato; Akiko Umetsu; Fuyuhiko Tamanoi

  SMALL GTPASES IN DISEASE, PART A, 2008, Peer-reviewed

  
• Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs

  Jie Lu; Monty Liong; Jeffrey I. Zink; Fuyuhiko Tamanoi

  SMALL, Aug. 2007, Peer-reviewed

  
• The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells

  Paul-Joseph Aspuria; Tatsuhiro Sato; Fuyuhiko Tamanoi

  CELL CYCLE, Jul. 2007, Peer-reviewed

  
• Small-molecule inhibitors of protein geranylgeranyltransferase type I

  Sabrina Castellano; Hannah D. G. Fiji; Sape S. Kinderman; Masaru Watanabe; Pablo de Leon; Fuyuhiko Tamanoi; Ohyun Kwon

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2007, Peer-reviewed

  
• Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.

  Lu J; Liong M; Sherman S; Xia T; Kovochich M; Nel AE; Zink JI; Tamanoi F

  Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences, May 2007, Peer-reviewed

  
• Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast

  Tomohiko Matsuo; Yoko Otsubo; Jun Urano; Fuyuhiko Tamanoi; Masayuki Yamamoto

  MOLECULAR AND CELLULAR BIOLOGY, Apr. 2007, Peer-reviewed

  
• Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

  Jun Urano; Tatsuhiro Sato; Tomohiko Matsuo; Yoko Otsubo; Masayuki Yamamoto; Fuyuhiko Tamanoi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2007, Peer-reviewed

  
• Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

  Parthive H. Patel; Fuyuhiko Tamanoi

  JOURNAL OF CELL SCIENCE, Oct. 2006, Peer-reviewed

  
• Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

  J Urano; MJ Comiso; L Guo; PJ Aspuria; R Deniskin; AP Tabancay; J Kato-Stankiewicz; F Tamanoi

  MOLECULAR MICROBIOLOGY, Nov. 2005, Peer-reviewed

  
• Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

  CL Gau; J Kato-Stankiewicz; C Jiang; S Miyamoto; L Guo; F Tamanoi

  MOLECULAR CANCER THERAPEUTICS, Jun. 2005, Peer-reviewed

  
• Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

  AP Tabancay; CL Gau; IMP Machado; EJ Uhlmann; DH Gutmann; L Guo; F Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2003, Peer-reviewed

  
• Drosophila Rheb GTPase is required for cell cycle progression and cell growth

  PH Patel; N Thapar; L Guo; M Martinez; J Maris; CL Gau; JA Lengyel; F Tamanoi

  JOURNAL OF CELL SCIENCE, Sep. 2003, Peer-reviewed

  
• A novel metal-chelating inhibitor of protein farnesyltransferase

  Akiyuki Hamasaki; Hayato Naka; Fuyuhiko Tamanoi; Kazuo Umezawa; Masami Otsuka

  Bioorganic and Medicinal Chemistry Letters, 05 May 2003

  
• Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells

  J Kato-Stankiewicz; Hakimi, I; G Zhi; J Zhang; Serebriiskii, I; L Guo; H Edamatsu; H Koide; S Menon; R Eckl; S Sakamuri; YC Lu; QZ Chen; S Agarwal; WR Baumbach; EA Golemis; F Tamanoi; Khazak, V

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2002, Peer-reviewed

  
• RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer

  BS Finlin; CL Gau; GA Murphy; HP Shao; T Kimel; RS Seitz; YF Chiu; D Botstein; PO Brown; F Tamanoi; DA Andres; CM Perou

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2001, Peer-reviewed

  
• Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: Implications in breast cancer

  S Pervin; R Singh; CL Gau; H Edamatsu; F Tamanoi; G Chaudhuri

  CANCER RESEARCH, Jun. 2001, Peer-reviewed

  
• Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines

  H Edamatsu; CL Gau; T Nemoto; L Guo; F Tamanoi

  ONCOGENE, Jun. 2000, Peer-reviewed

  
• The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

  J Urano; AP Tabancay; WL Yang; F Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2000, Peer-reviewed

  
• Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe

  WL Yang; J Urano; F Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2000, Peer-reviewed

  
• A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors

  K Del Villar; J Urano; L Guo; F Tamanoi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1999, Peer-reviewed

  
• Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70

  Nicole G. G. Robinson; Lea Guo; Jun Imai; Akio Toh-E; Yasushi Matsui; Fuyuhiko Tamanoi

  Molecular and Cellular Biology, May 1999, Peer-reviewed

  
• Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

  N Suzuki; J Urano; F Tamanoi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1998, Peer-reviewed

  
• Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

  N Suzuki; K Del Villar; F Tamanoi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 1998, Peer-reviewed

  
• Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I

  Keith Del Villar; Hiroshi Mitsuzawa; Wenli Yang; Isabel Sattler; Fuyuhiko Tamanoi

  Journal of Biological Chemistry, 1997, Peer-reviewed

  
• Advances in the development of farnesyltransferase inhibitors: Substrate recognition by protein farnesyltransferase

  Wenli Yang; Keith Del Villar; Jun Urano; Hiroshi Mitsuzawa; Fuyuhiko Tamanoi

  Journal of Cellular Biochemistry, 1997, Peer-reviewed

  
• C-terminal motifs found in Ras-superfamily G-proteins: CAAX and C-seven motifs

  K. Del Villar; D. Dorin; I. Sattler; J. Urano; P. Poullet; N. Robinson; H. Mitsuzawa; F. Tamanoi

  Biochemical Society Transactions, 1996, Peer-reviewed

  
• Kir, a novel ras-family G-protein, induces invasive pseudohyphal growth in Saccharomyces cerevisiae

  D Dorin; L Cohen; K DelVillar; P Poullet; R Mohr; M Whiteway; O Witte; F Tamanoi

  ONCOGENE, Dec. 1995, Peer-reviewed

  
• MUTANT FARNESYLTRANSFERASE BETA-SUBUNIT OF SACCHAROMYCES-CEREVISIAE THAT CAN SUBSTITUTE FOR GERANYLGERANYLTRANSFERASE TYPE-I BETA-SUBUNIT

  H MITSUZAWA; K ESSON; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1995, Peer-reviewed

  
• GapIII, a new brain‐enriched member of the GTPase‐activating protein family

  H. Baba; B. Fuss; J. Urano; P. Poullet; J. B. Watson; F. Tamanoi; W. B. Macklin

  Journal of Neuroscience Research, 1995, Peer-reviewed

  
• TRANSCRIPTIONAL ACTIVATION OF A RAS-LIKE GENE (KIR) BY ONCOGENIC TYROSINE KINASES

  L COHEN; R MOHR; YY CHEN; M HUANG; R KATO; D DORIN; F TAMANOI; A GOGA; D AFAR; N ROSENBERG; O WITTE

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1994, Peer-reviewed

  
• BIOCHEMICAL-CHARACTERIZATION OF YEAST RAS2 MUTANTS REVEALS A NEW REGION OF RAS PROTEIN INVOLVED IN THE INTERACTION WITH GTPASE-ACTIVATING PROTEINS

  DR WOOD; P POULLET; BA WILSON; M KHALIL; K TANAKA; JF CANNON; F TAMANOI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1994, Peer-reviewed

  
• IDENTIFICATION OF RAS FARNESYLTRANSFERASE INHIBITORS BY MICROBIAL SCREENING

  M HARA; K AKASAKA; S AKINAGA; M OKABE; H NAKANO; R GOMEZ; D WOOD; M UH; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 1993, Peer-reviewed

  
• TERMINAL REGION RECOGNITION FACTOR-I, A DNA-BINDING PROTEIN RECOGNIZING THE INVERTED TERMINAL REPEATS OF THE PGK1 LINEAR DNA PLASMIDS

  DG MCNEEL; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1991, Peer-reviewed

  
• S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation

  Asao Fujiyama; Susumu Tsunasawa; Fuyuhiko Tamanoi; Fumio Sakiyama

  Journal of Biological Chemistry, 25 Sep. 1991, Peer-reviewed

  
• YEAST CAL1 IS A STRUCTURAL AND FUNCTIONAL HOMOLOG TO THE DPR1 (RAM) GENE INVOLVED IN RAS PROCESSING

  Y OHYA; M GOEBL; LE GOODMAN; S PETERSENBJORN; JD FRIESEN; F TAMANOI; Y ANRAKU

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed

  
• PROTEIN GERANYLGERANYLTRANSFERASE OF SACCHAROMYCES-CEREVISIAE IS SPECIFIC FOR CYS-XAA-XAA-LEU MOTIF PROTEINS AND REQUIRES THE CDC43 GENE-PRODUCT BUT NOT THE DPR1 GENE-PRODUCT

  AA FINEGOLD; DI JOHNSON; CC FARNSWORTH; MH GELB; JUDD, SR; JA GLOMSET; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 1991, Peer-reviewed

  
• IRA2, AN UPSTREAM NEGATIVE REGULATOR OF RAS IN YEAST, IS A RAS GTPASE-ACTIVATING PROTEIN

  K TANAKA; BK LIN; DR WOOD; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1991, Peer-reviewed

  
• MUTANTS OF SACCHAROMYCES-CEREVISIAE DEFECTIVE IN THE FARNESYLATION OF RAS PROTEINS

  LE GOODMAN; JUDD, SR; CC FARNSWORTH; S POWERS; MH GELB; JA GLOMSET; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1990, Peer-reviewed

  
• RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus

  Asao Fujiyama; Fuyuhiko Tamanoi

  Journal of Biological Chemistry, 25 Feb. 1990, Peer-reviewed

  
• IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein

  K. Tanaka; M. Nakafuku; F. Tamanoi; Y. Kaziro; K. Matsumoto; E. A. Toh

  Molecular and Cellular Biology, 1990, Peer-reviewed

  
• PHOSPHORYLATION OF RAS1 AND RAS2 PROTEINS IN SACCHAROMYCES-CEREVISIAE

  AR COBITZ; EH YIM; WR BROWN; CM PEROU; F TAMANOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1989, Peer-reviewed

  
• Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localiation of ras proteins

  Lauri E. Goodman; Charles M. Perou; Asao Fujiyama; Fuyuhiko Tamanoi

  Yeast, 1988, Peer-reviewed

  
• A NOVEL YEAST MUTANT DEFECTIVE IN THE PROCESSING OF RAS PROTEINS - ASSESSMENT OF THE EFFECT OF THE MUTATION ON PROCESSING STEPS

  A FUJIYAMA; K MATSUMOTO; F TAMANOI

  EMBO JOURNAL, Jan. 1987, Peer-reviewed

  
• ANALYSIS OF THE TRANSFORMING POTENTIAL OF THE HUMAN H-RAS GENE BY RANDOM MUTAGENESIS

  O FASANO; T ALDRICH; F TAMANOI; E TAPAROWSKY; M FURTH; M WIGLER

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, Peer-reviewed

  
• A PRODUCT OF YEAST RAS2 GENE IS A GUANINE-NUCLEOTIDE BINDING-PROTEIN

  F TAMANOI; M WALSH; T KATAOKA; M WIGLER

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, Peer-reviewed

  
• INITIATION OF ADENOVIRUS DNA-REPLICATION INVITRO REQUIRES A SPECIFIC DNA-SEQUENCE

  F TAMANOI; BW STILLMAN

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, Peer-reviewed

  
• REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIOBONUCLEIC ACID .21. INITIATION OF DNA-REPLICATION AT THE PRIMARY ORIGIN OF BACTERIOPHAGE-T7 BY PURIFIED PROTEINS - REQUIREMENT FOR T7 RNA-POLYMERASE

  LJ ROMANO; F TAMANOI; CC RICHARDSON

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, Peer-reviewed

  
• REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIBONUCLEIC-ACID .17. PHYSICAL MAPPING OF PRIMARY AND SECONDARY ORIGINS OF BACTERIOPHAGE-T7 DNA-REPLICATION

  F TAMANOI; H SAITO; CC RICHARDSON

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, Peer-reviewed

  
• REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIBONUCLEIC-ACID .18. NUCLEOTIDE-SEQUENCE OF THE PRIMARY ORIGIN OF BACTERIOPHAGE-T7 DNA-REPLICATION - RELATIONSHIP TO ADJACENT GENES AND REGULATORY ELEMENTS

  H SAITO; S TABOR; F TAMANOI; CC RICHARDSON

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, Peer-reviewed

  

Misc.

• がんの鶏卵モデル

  小松葵; 松本光太郎; 玉野井冬彦

  患者由来のがんモデルを用いたがん研究実践ガイド, Oct. 2019

  
• Treatment of metastatic breast cancer using two nanoparticles combined with siRNA targeting Twist1 to inhibit EMT

  James B. Finlay; Cai M. Roberts; Gina Lowe; Ling Peng; Jeff I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin

  CANCER RESEARCH, May 2015

  
• Interruption of K-Ras/PAK1/Crk pathway has a dramatic anti-tumor effect in NSCLC

  Fariborz (Fred) Mortazavi; Jie Lu; Aljilani Amir; Ryan Phan; Fuyuhiko Tamanoi

  MOLECULAR CANCER RESEARCH, Dec. 2014

  
• Light-controllable nano-drug delivery system with deep tissue penetrating ability for cancer therapy with two-photon-triggered nanoimpellers

  Jie Lu; Jonas Croissant; Jean-Olivier Jean-Olivier Durand; Tania Guardado-Alvarez; Jeffrey I. Zink; Fuyuhiko Tamanoi

  CANCER RESEARCH, Oct. 2014

  
• Recent progress in the study of the Rheb family GTPases

  Jeffrey J. Heard; Valerie Fong; S. Zahra Bathaie; Fuyuhiko Tamanoi

  CELLULAR SIGNALLING, Sep. 2014

  
• Nanomachine-controlled cargo release monitored in single living cells

  Bryana L. Henderson; Yuen A. Lau; Eunshil Choi; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2011

  
• Real-time rate measurement of cargo release by nanoimpellers in a single cell

  Yuen A. Lau; Bryana Henderson; Jie Lu; Fuyuhiko Tamanoi; Jeff I. Zink

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2011

  
• Conservation of the Tsc/Rheb/TORC1/S6K/S6 signaling in fission yeast

  Akio Nakashima; Fuyuhiko Tamanoi

  Enzymes, 2010, Invited

  
• Blocking Rheb posttranslational processing and localization for cancer treatment

  Ariella Hanker; Rhonda Wilder; Elizabeth Henske; Fuyuhiko Tamanoi; Adrienne Cox; Channing Der

  CANCER RESEARCH, May 2009

  
• In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase I

  Jie Lu; Lai Chan; Hannah Fiji; Russell Dahl; Ohyun Kwon; Fuyuhiko Tamanoi

  CANCER RESEARCH, May 2009

  
• Chemical biology/chemical genetics/chemical genomics: Importance of chemical library

  Fumihiko Kugawa; Masaru Watanabe; Fuyuhiko Tamanoi

  Chem-Bio Informatics Journal, 2007

  
• NEW ACTIVATED RAS2 MUTATIONS IDENTIFIED IN SACCHAROMYCES-CEREVISIAE

  BA WILSON; M KHALIL; F TAMANOI; JF CANNON

  ONCOGENE, Dec. 1993

  

Presentations

• Gadolinium-loaded mesoporous silica nanoparticles trigger destruction of tumor spheroids upon irradiation with monochromatic X-ray

  Yue Ma; Fuyuhiko Tamanoi

  The 8th Japan-China Symposium on Nanomedicine, 11 Jun. 2021, Invited

  
• A new radiation therapy by combining gadolinium-loaded nanoparticles and monochromatic X-ray

  Fuyuhiko Tamanoi

  E-MRS Spring meeting 2021, 03 Jun. 2021, Invited

  
• 量子ビームとナノ材料研究により拓かれる量子ナノ医療研究

  玉野井冬彦

  ナノ学会第18回大会, May 2020

  
• Nanomedicine and Cancer Therapy

  Fuyuhiko Tamanoi

  Kyoto University-Academia Sinica Bilateral Symposium, 18 Dec. 2019, Invited

  
• Novel radiation therapy employing monochromatic X-ray and nanoparticles

  Fuyuhiko Tamanoi

  First QNM-iCeMS Symposium: Exploring New Approaches for Cancer Therapy, 13 Dec. 2019, Invited

  
• Developing a Novel radiation therapy involving monochromatic X-ray and Auger effect

  Fuyuhiko Tamanoi

  13th International Symposium on Nanomedicine, 06 Dec. 2019, Invited

  
• Developing a novel radiation therapy by employing monochromatic X-ray and nanoparticles

  Fuyuhiko Tamanoi

  International Symposium: New Technology for Diagnosis and Therapeutics of Cancer, 02 Dec. 2019, Invited

  
• Chicken egg tumor model and boron neutron capture therapy (BNCT)

  Fuyuhiko Tamanoi

  Annual Retreat, Kyoto University, 22 Sep. 2019, Invited

  
• A new radiation therapy emerging from the convergence of nanotechnology and particle physics

  Fuyuhiko Tamanoi

  HeKKSaGOn 6th German-Japanese University Presidents’ Conference, 12 Sep. 2019, Invited

  
• Patient-derived chicken egg tumor model (PDcE model)

  玉野井冬彦

  講演会：患者由来がんモデル～基礎研究から臨床応用まで～, 02 Aug. 2019, Invited

  
• Patient-derived tumor models and KRAS inhibitors

  Fuyuhiko Tamanoi

  FASEB Summer Research Conference, 24 Jun. 2019, Invited

  
• Efficacy of biodegradable PMO to inhibit tumor growth in animal models

  Fuyuhiko Tamanoi

  The 7th China-Japan Symposium on Nanomedicine, 25 May 2019, Invited

  
• Patient-derived Chicken Egg Tumor Model, Precision Medicine and Nanoparticle-mediated Cancer Therap

  Fuyuhiko Tamanoi

  Patient-derived Chicken Egg Tumor Model, Precision Medicine and Nanoparticle-mediated Cancer Therap, 26 Mar. 2019, Invited

  
• Patient-derived chicken egg tumor modeland tailor-made medicine

  Fuyuhiko Tamanoi

  The SPIRITS International Symposium-2019 "Regulation of cell fate and disease treatment", 28 Jan. 2019, Invited

  
• Tumor Targeting of Mesoporous Silica Nanoparticles Characterized by Using Chicken Egg Tumor Model

  Fuyuhiko Tamanoi

  2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine, 14 Dec. 2018, Invited

  
• Boron Neutron Capture Therapy and Nanotechnology

  Fuyuhiko Tamanoi

  12th International Symposium on Nanomedicine, 07 Dec. 2018

  
• Boron Neutron Capture Therapy and Nanotechnology

  Fuyuhiko Tamanoi

  Kyoto-UCLA, Harnessing Physical Forces for Medical Applocations Symposium, Nov. 2018

  
• 癌の鶏卵モデル：患者由来がんモデルとナノ治療開発系としての可能性

  玉野井 冬彦

  新しい治療法の開発を目指す患者由来がんモデル, 28 Jun. 2018, Invited

  
• Cancer therapy using mesoporous silica nanoparticles

  Fuyuhiko Tamanoi

  Mesoporous Materials: 1991-2018. International Symposium, 10 Apr. 2018, Invited

  

External funds: Kakenhi

• Novel cancer radiation therapy employing monochromatic X-rays and nanoparticles

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 28:Nano/micro science and related fields

  Kyoto University

  Fuyuhiko Tamanoi

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  高Z元素;単色X線;ナノ粒子;がんスフェロイド;DNA二重鎖切断;ヨウ素含有DNA結合色素;オージェ治療;アポトーシス;オージェ電子;K端エネルギー;オージェ効果;高Z元素担持ナノ粒子;マウス実験;単色Ｘ線;高Ｚ元素;Auger効果

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00331/
• Novel Boron containing Nanoparticles and their application in BNCT.

  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)

  Kyoto University

  Fuyuhiko TAMANOI

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  メソポーラスシリカナノ粒子;がん蓄積;がんの鶏卵モデル;がんスフェロイド;ホウ素中性子捕捉療法;単色X線;オージェ効果;ホウ素含有メソポーラスシリカナノ粒子;鶏卵のがんモデル;がんへの蓄積;癌へのターゲティング;鶏卵の癌モデル;ナノ材料;ナノバイオ;放射線

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21764/