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玉野井 冬彦

タマノイ フユヒコ

高等研究院 物質－細胞統合システム拠点 特定教授

玉野井 冬彦
list
    Last Updated :2025/05/02

    基本情報

    学位

    • 理学修士(東京大学)
    • 理学博士(名古屋大学)

    使用言語

    • 日本語
    • 英語

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/02

      研究

      研究テーマ・研究概要

      • 研究テーマ

        ナノ粒子の構築と癌治療への応用

      • 研究概要

        私達はナノ粒子を構築している。一つの特徴は多孔性の構造をしているので、表面積がひろいことである。そこに抗癌剤などを吸着することができる。抗癌剤を埋め込んだナノ粒子の効果を癌の動物モデルを使い検討している。

      研究分野

      • ライフサイエンス, 腫瘍生物学

      論文

      • Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape
        Miguel Gisbert-Garzaran; Daniel Lozano; Kotaro Matsumoto; Aoi Komatsu; Miguel Manzano; Fuyuhiko Tamanoi; Maria Vallet-Regi
        ACS Applied Materials and Interfaces, 2021年03月03日
        この論文にアクセスする：
      • Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy.
        Mathilde Laird; Kotaro Matsumoto; Yuya Higashi; Aoi Komatsu; Art Raitano; Kendall Morrison; Minoru Suzuki; Fuyuhiko Tamanoi
        Nanoscale advances, 2023年05月02日
        この論文にアクセスする：
      • Tumor Accumulation of PIP-Based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model
        Yuya Higashi; Shuji Ikeda; Kotaro Matsumoto; Shinsuke Satoh; Aoi Komatsu; Hiroshi Sugiyama; Fuyuhiko Tamanoi
        Cancers, 2022年02月14日
      • The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.
        Aoi Komatsu; Kotaro Matsumoto; Yuki Yoshimatsu; Yooksil Sin; Arisa Kubota; Tomoki Saito; Ayaka Mizumoto; Shinya Ohashi; Manabu Muto; Rei Noguchi; Tadashi Kondo; Fuyuhiko Tamanoi
        Cells, 2021年10月01日
      • PROCESSING AND FATTY-ACID ACYLATION OF RAS PROTEINS
        F TAMANOI; A FUJIYAMA
        JOURNAL OF CELLULAR BIOCHEMISTRY, 1987年, 査読有り
      • DIFFERENTIAL ACTIVATION OF YEAST ADENYLATE-CYCLASE BY WILD-TYPE AND MUTANT RAS PROTEINS
        D BROEK; N SAMIY; O FASANO; A FUJIYAMA; F TAMANOI; J NORTHUP; M WIGLER
        CELL, 1985年, 査読有り
      • Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray
        Yuya Higashi; Kotaro Matsumoto; Hiroyuki Saitoh; Ayumi Shiro; Yue Ma; Mathilde Laird; Shanmugavel Chinnathambi; Albane Birault; Tan Le Hoang Doan; Ryo Yasuda; Toshiki Tajima; Tetsuya Kawachi; Fuyuhiko Tamanoi
        Scientific Reports, 2021年12月
        この論文にアクセスする：
      • Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy
        Fuyuhiko Tamanoi; Shanmugavel Chinnathambi; Mathilde Laird; Aoi Komatsu; Albane Birault; Takushi Takata; Tan Le-Hoang Doan; Ngoc Xuan Dat Mai; Arthur Raitano; Kendall Morrison; Minoru Suzuki; Kotaro Matsumoto
        International Journal of Molecular Sciences, 2021年02月24日, 査読有り, 筆頭著者
      • Facile synthesis of biodegradable mesoporous functionalized-organosilica nanoparticles for enhancing the anti-cancer efficiency of cordycepin
        Ngoc Xuan Dat Mai; Uyen-Chi Nguyen Le; Linh Ho Thuy Nguyen; Hanh Thi Kieu Ta; Ha Van Nguyen; Tri Minh Le; Thang Bach Phan; Lien-Thuong Thi Nguyen; Fuyuhiko Tamanoi; Tan Le Hoang Doan
        Microporous and Mesoporous Materials, 2021年02月, 査読有り
      • Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy
        Shanmugavel Chinnathambi; Fuyuhiko Tamanoi
        Pharmaceutics, 2020年09月18日
      • Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy.
        Fuyuhiko Tamanoi; Kotaro Matsumoto; Tan Le Hoang Doan; Ayumi Shiro; Hiroyuki Saitoh
        Nanomaterials (Basel, Switzerland), 2020年07月09日, 査読有り, 筆頭著者
      • Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle-Based Anticancer Drug.
        Ngoc Xuan Dat Mai; Albane Birault; Kotaro Matsumoto; Hanh Kieu Thi Ta; Soontaree Grace Intasa-Ard; Kendall Morrison; Phan Bach Thang; Tan Le Hoang Doan; Fuyuhiko Tamanoi
        ChemMedChem, 2020年04月03日, 査読有り
      • Recent excitements in the study of the CAM assay.
        Fuyuhiko Tamanoi
        The Enzymes, 2019年10月, 査読有り
      • Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy.
        Kotaro Matsumoto; Hiroyuki Saitoh; Tan Le Hoang Doan; Ayumi Shiro; Keigo Nakai; Aoi Komatsu; Masahiko Tsujimoto; Ryo Yasuda; Tetsuya Kawachi; Toshiki Tajima; Fuyuhiko Tamanoi
        Scientific reports, 2019年09月30日, 査読有り
        この論文にアクセスする：
      • Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues.
        Aoi Komatsu; Kotaro Matsumoto; Tomoki Saito; Manabu Muto; Fuyuhiko Tamanoi
        Cells, 2019年05月10日, 査読有り
      • Relationship between the glutathione-responsive degradability of thiol-organosilica nanoparticles and the chemical structures
        Doura Tomoshiro; Nishio Tadashi; Tamanoi Fuyuhiko; Nakamura Michihiro
        JOURNAL OF MATERIALS RESEARCH, 2019年04月15日, 査読有り
      • がんの個別化医療を切り拓く鶏卵モデル
        玉野井 冬彦; 遠藤 良夫; 宇都 義浩; 楠橋 由貴; 二若 真菜; 松本 光太郎
        実験医学, 2019年01月, 査読有り
      • Biodegradability of Disulfide-Organosilica Nanoparticles Evaluated by Soft X-ray Photoelectron Spectroscopy: Cancer Therapy Implications
        Harutaka Mekaru; Akitaka Yoshigoe; Michihiro Nakamura; Tomohiro Doura; Fuyuhiko Tamanoi
        ACS APPLIED NANO MATERIALS, 2019年01月, 査読有り
      • Miniaturization of thiol-organosilica nanoparticles induced by an anionic surfactant
        Tomohiro Doura; Fuyuhiko Tamanoi; Michihiro Nakamura
        Journal of Colloid and Interface Science, 2018年09月15日, 査読有り
      • Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer.
        Binh Thanh Vu; Sophia Allaf Shahin; Jonas Croissant; Yevhen Fatieiev; Kotaro Matsumoto; Tan Le-Hoang Doan; Tammy Yik; Shirleen Simargi; Altagracia Conteras; Laura Ratliff; Chiara Mauriello Jimenez; Laurence Raehm; Niveen Khashab; Jean-Olivier Durand; Carlotta Glackin; Fuyuhiko Tamanoi
        Scientific reports, 2018年06月04日, 査読有り
        この論文にアクセスする：
      • Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer.
        Shahin SA; Wang R; Simargi SI; Contreras A; Parra Echavarria L; Qu L; Wen W; Dellinger T; Unternaehrer J; Tamanoi F; Zink JI; Glackin CA
        Nanomedicine : nanotechnology, biology, and medicine, 2018年04月, 査読有り
      • Isolation and characterization of the primary epithelial breast cancer cells and the adjacent normal epithelial cells from Iranian women's breast cancer tumors.
        Faridi N; Bathaie SZ; Abroun S; Farzaneh P; Karbasian H; Tamanoi F; Mohagheghi MA
        Cytotechnology, 2018年04月, 査読有り
      • An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation
        Jeffrey J. Heard; Ivy Phung; Mark I. Potes; Fuyuhiko Tamanoi
        BMC Cancer, 2018年01月10日, 査読有り
      • Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models.
        Le Hoang; Doan T; Mai NXD; Matsumoto K; Tamanoi F
        The Enzymes, 2018年, 査読有り
      • Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application.
        Vallet-Regi M; Tamanoi F
        The Enzymes, 2018年, 査読有り
      • Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model.
        Matsumoto K; Le Hoang; Doan T; Mai NXD; Nakai K; Komatsu A; Tamanoi F
        The Enzymes, 2018年, 査読有り
      • A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group
        Ayumi Tanaka; Mohamed O. Radwan; Akiyuki Hamasaki; Asumi Ejima; Emiko Obata; Ryoko Koga; Hiroshi Tateishi; Yoshinari Okamoto; Mikako Fujita; Mitsuyoshi Nakao; Kazuo Umezawa; Fuyuhiko Tamanoi; Masami Otsuka
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017年08月, 査読有り
      • Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models
        Cai M. Roberts; Sophia Allaf Shahin; Wei Wen; James B. Finlay; Juyao Dong; Ruining Wang; Thanh H. Dellinger; Jeffrey I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017年04月, 査読有り
      • Exploiting Enzyme Alterations in Cancer for Drug Activation, Drug Delivery, and Nanotherapy
        Joel Y. Hayashi; Fuyuhiko Tamanoi
        Enzymes, 2017年, 査読有り
      • Exploiting Enzyme Alterations in Cancer for Drug Activation, Drug Delivery, and Nanotherapy.
        Hayashi JY; Tamanoi F
        The Enzymes, 2017年, 査読有り
      • Mevalonate Pathway and Human Cancers
        Seyedeh Zahra Bathaie; Mahboobeh Ashrafi; Mahshid Azizian; Fuyuhiko Tamanoi
        CURRENT MOLECULAR PHARMACOLOGY, 2017年, 査読有り
      • Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
        Jonas G. Croissant; Yevhen Fatieiev; Khachatur Julfakyan; Jie Lu; Abdul-Hamid Emwas; Dalaver H. Anjum; Haneen Omar; Fuyuhiko Tamanoi; Jeffrey I. Zink; Niveen M. Khashab
        CHEMISTRY-A EUROPEAN JOURNAL, 2016年10月, 査読有り
      • Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells
        Jonas G. Croissant; Yevhen Fatieiev; Haneen Omar; Dalaver H. Anjum; Andrey Gurinov; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink; Niveen M. Khashab
        CHEMISTRY-A EUROPEAN JOURNAL, 2016年07月, 査読有り
      • Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging
        Jonas G. Croissant; Dingyuan Zhang; Shahad Alsaiari; Jie Lu; Lin Deng; Fuyuhiko Tamanoi; Abdulaziz M. AlMalik; Jeffrey I. Zink; Niveen M. Khashab
        JOURNAL OF CONTROLLED RELEASE, 2016年05月, 査読有り
      • Rheb-CADシグナル伝達経路によるピリミジンヌクレオチド生合成促進機構
        下野 航; 佐藤 龍洋; 玉野井 冬彦; 服部 成介
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月
      • TORの実像に迫れ! Rheb-mTORC1によるピリミジンヌクレオチド生合成制御機構の解析
        佐藤 龍洋; 玉野井 冬彦; 服部 成介
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月
      • Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy
        Harutaka Mekaru; Jie Lu; Fuyuhiko Tamanoi
        ADVANCED DRUG DELIVERY REVIEWS, 2015年12月, 査読有り
      • Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden
        James Finlay; Cai M. Roberts; Juyao Dong; Jeffrey I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015年10月, 査読有り
      • Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells
        Jie Lu; Kohei Yoshimura; Koichi Goto; Craig Lee; Ken Hamura; Ohyun Kwon; Fuyuhiko Tamanoi
        PLOS ONE, 2015年09月, 査読有り
      • Significance of filamin A in mTORC2 function in glioblastoma
        Naphat Chantaravisoot; Piriya Wongkongkathep; Joseph A. Loo; Paul S. Mischel; Fuyuhiko Tamanoi
        MOLECULAR CANCER, 2015年07月, 査読有り
      • Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis
        Fariborz Mortazavi; Jie Lu; Ryan Phan; Michael Lewis; Kenny Trinidad; Amir Aljilani; Gholamhossein Pezeshkpour; Fuyuhiko Tamanoi
        BMC CANCER, 2015年05月, 査読有り
      • Functional Nanovalves on Protein-Coated Nanoparticles for In vitro and In vivo Controlled Drug Delivery
        Angela A. Hwang; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink
        SMALL, 2015年01月, 査読有り
      • Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP-and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity
        Tatsuhiro Sato; Hitomi Akasu; Wataru Shimono; Chisa Matsu; Yuki Fujiwara; Yoshio Shibagaki; Jeffrey J. Heard; Fuyuhiko Tamanoi; Seisuke Hattori
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2015年01月, 査読有り
      • Hybrid Mesoporous Silica Nanoparticles with pH-Operated and Complementary H-Bonding Caps as an Autonomous Drug-Delivery System
        Christophe Theron; Audrey Gallud; Carole Carcel; Magali Gary-Bobo; Marie Maynadier; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink; Michel Wong Chi Man
        CHEMISTRY-A EUROPEAN JOURNAL, 2014年07月, 査読有り
      • Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter
        Akio Nakashima; Shinji Kamada; Fuyuhiko Tamanoi; Ushio Kikkawa
        BIOLOGY OPEN, 2014年06月, 査読有り
      • Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves
        Jonas Croissant; Arnaud Chaix; Olivier Mongin; Miao Wang; Sebastien Clement; Laurence Raehm; Jean-Olivier Durand; Vincent Hugues; Mireille Blanchard-Desce; Marie Maynadier; Audrey Gallud; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Daniel P. Ferris; Derrick Tarn; Jeffrey I. Zink
        SMALL, 2014年05月, 査読有り
      • ファルネシルトランスフェラーゼの特異的阻害を目的とした亜鉛キレーターの設計及び合成
        田中 亜友美; 岡本 良成; 藤田 美歌子; 梅澤 和夫; 玉野井 冬彦; 大塚 雅巳
        日本薬学会年会要旨集, 2014年03月, 査読有り
      • Silica-Based Nanoporous Materials
        Eunshil Choi; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink
        ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2014年03月, 査読有り
      • Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*
        Kimberly Coffman; Bing Yang; Jie Lu; Ashley L. Tetlow; Emelia Pelliccio; Shan Lu; Da-Chuan Guo; Chun Tang; Meng-Qiu Dong; Fuyuhiko Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2014年02月, 査読有り
      • Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers
        Jonas Croissant; Marie Maynadier; Audrey Gallud; Harmel Peindy N'Dongo; Jeff L. Nyalosaso; Gaelle Derrien; Clarence Charnay; Jean-Olivier Durand; Laurence Raehm; Francoise Serein-Spirau; Nathalie Cheminet; Thibaut Jarrosson; Olivier Mongin; Mireille Blanchard-Desce; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Derrick Tarn; Tania M. Guardado-Alvarez; Jeffrey I. Zink
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013年12月, 査読有り
      • De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.
        Akhavan D; Pourzia AL; Nourian AA; Williams KJ; Nathanson D; Babic I; Villa GR; Tanaka K; Nael A; Yang H; Dang J; Vinters HV; Yong WH; Flagg M; Tamanoi F; Sasayama T; James CD; Kornblum HI; Cloughesy TF; Cavenee WK; Bensinger SJ; Mischel PS
        Cancer discovery, 2013年05月, 査読有り
      • In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
        Drazen B. Zimonjic; Lai N. Chan; Veenu Tripathi; Jie Lu; Ohyun Kwon; Nicholas C. Popescu; Douglas R. Lowy; Fuyuhiko Tamanoi
        BMC CANCER, 2013年04月, 査読有り
      • Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition
        Rolando E. Yanes; Derrick Tarn; Angela A. Hwang; Daniel P. Ferris; Sean P. Sherman; Courtney R. Thomas; Jie Lu; April D. Pyle; Jeffrey I. Zink; Fuyuhiko Tamanoi
        SMALL, 2013年03月, 査読有り
      • A two-hybrid approach to identify inhibitors of the ras-raf interaction
        Vladimir Khazak; Susanne Eyrisch; Juran Kato; Fuyuhiko Tamanoi; Erica A. Golemis
        Enzymes, 2013年, 査読有り
      • Tuning the Biodegradability of Silicon Nanoparticles for Drug Delivery
        Nick K. Hon; Zory Shaposhnik; Eric D. Diebold; Fuyuhiko Tamanoi; Bahram Jalali
        SURFACE TREATMENTS FOR BIOMEDICAL APPLICATIONS 3, 2013年, 査読有り
      • Tailoring the biodegradability of porous silicon nanoparticles
        Nick K. Hon; Zory Shaposhnik; Eric D. Diebold; Fuyuhiko Tamanoi; Bahram Jalali
        JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012年12月, 査読有り
      • Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase
        Akio Nakashima; Yoko Otsubo; Akira Yamashita; Tatsuhiro Sato; Masayuki Yamamoto; Fuyuhiko Tamanoi
        JOURNAL OF CELL SCIENCE, 2012年12月, 査読有り
      • PAK1 Kinase Promotes Cell Motility and Invasiveness through CRK-II Serine Phosphorylation in Non-Small Cell Lung Cancer Cells
        Matthew Rettig; Kenny Trinidad; G. Pezeshkpour; Patrick Frost; Sherven Sharma; Farhad Moatamed; Fuyuhiko Tamanoi; Fariborz Mortazavi
        PLOS ONE, 2012年07月, 査読有り
      • Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.
        Yanes RE; Tamanoi F
        Therapeutic delivery, 2012年03月, 査読有り
      • In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification
        Jie Lu; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012年02月, 査読有り
      • Continuous spectroscopic measurements of photo-stimulated release of molecules by nanomachines in a single living cell
        Yuen A. Lau; Bryana L. Henderson; Jie Lu; Daniel P. Ferris; Fuyuhiko Tamanoi; Jeffrey I. Zink
        NANOSCALE, 2012年, 査読有り
      • Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I
        Lai N. Chan; Hannah D. G. Fiji; Masaru Watanabe; Ohyun Kwon; Fuyuhiko Tamanoi
        PLOS ONE, 2011年10月, 査読有り
      • Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells
        Daniel P. Ferris; Jie Lu; Chris Gothard; Rolando Yanes; Courtney R. Thomas; John-Carl Olsen; J. Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I. Zink
        SMALL, 2011年07月, 査読有り
      • pH-Operated Mechanized Porous Silicon Nanoparticles
        Min Xue; Xing Zhong; Zory Shaposhnik; Yongquan Qu; Fuyuhiko Tamanoi; Xiangfeng Duan; Jeffrey I. Zink
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011年06月, 査読有り
      • Ras signaling in yeast.
        Tamanoi F
        Genes & cancer, 2011年03月, 査読有り
      • Activating mutations of TOR (target of rapamycin)
        Molly Hardt; Naphat Chantaravisoot; Fuyuhiko Tamanoi
        GENES TO CELLS, 2011年02月, 査読有り
      • Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves
        Huan Meng; Min Xue; Tian Xia; Yan-Li Zhao; Fuyuhiko Tamanoi; J. Fraser Stoddart; Jeffrey I. Zink; Andre E. Nel
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010年09月, 査読有り
      • Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals
        Jie Lu; Monty Liong; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi
        SMALL, 2010年08月, 査読有り
      • Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells
        Christopher Hom; Jie Lu; Monty Liong; Hanzhi Luo; Zongxi Li; Jeffrey I. Zink; Fuyuhiko Tamanoi
        SMALL, 2010年06月, 査読有り
      • Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy
        Huaidong Jiang; Changyong Song; Chien-Chun Chen; Rui Xu; Kevin S. Raines; Benjamin P. Fahimian; Chien-Hung Lu; Ting-Kuo Lee; Akio Nakashima; Jun Urano; Tetsuya Ishikawa; Fuyuhiko Tamanoi; Jianwei Miao
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010年06月, 査読有り
      • Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
        T. Sato; A. Nakashima; L. Guo; K. Coffman; F. Tamanoi
        ONCOGENE, 2010年05月, 査読有り
      • Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
        Akio Nakashima; Tatsuhiro Sato; Fuyuhiko Tamanoi
        JOURNAL OF CELL SCIENCE, 2010年03月, 査読有り
      • Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
        A. B. Hanker; N. Mitin; R. S. Wilder; E. P. Henske; F. Tamanoi; A. D. Cox; C. J. Der
        ONCOGENE, 2010年01月, 査読有り
      • Rheb G-Proteins and the Activation of mTORC1.
        Parmar N; Tamanoi F
        The Enzymes, 2010年, 査読有り
      • [Rheb-mTOR signaling pathway involved in tumor formation].
        Sato T; Nakashima A; Tamanoi F
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2010年01月, 査読有り
      • A novel approach to tag and identify geranylgeranylated proteins
        Lai N. Chan; Courtenay Hart; Lea Guo; Tamara Nyberg; Brandon S. J. Davies; Loren G. Fong; Stephen G. Young; Brian J. Agnew; Fuyuhiko Tamanoi
        ELECTROPHORESIS, 2009年10月, 査読有り
      • mTOR活性変異体の同定およびRheb-mTORシグナル伝達の解析
        佐藤 龍洋; 服部 成介; 玉野井 冬彦
        日本生化学会大会プログラム・講演要旨集, 2009年09月
      • Construction of a model cell line for the assay of MDR1 (Multi Drug Resistance gene-1) substrates/inhibitors using HeLa cells
        Fumihiko Kugawa; T. Suzuki; M. Miyata; K. Tomono; F. Tamanoi
        Pharmazie, 2009年05月, 査読有り
      • In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
        Jie Lu; Lai Chan; Hannah D. G. Fiji; Russell Dahl; Ohyun Kwon; Fuyuhiko Tamanoi
        MOLECULAR CANCER THERAPEUTICS, 2009年05月, 査読有り
      • Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein
        Tatsuhiro Sato; Akio Nakashima; Lea Guo; Fuyuhiko Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2009年05月, 査読有り
      • The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner
        Jun Zhou; Chantal Chanel Vos; Ada Gjyrezi; Minoru Yoshida; Fadlo R. Khuri; Fuyuhiko Tamanoi; Paraskevi Giannakakou
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2009年04月, 査読有り
      • Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome
        Brandon S. J. Davies; Shao H. Yang; Emily Farber; Roger Lee; Suzanne B. Buck; Douglas A. Andres; H. Peter Spielmann; Brian J. Agnew; Fuyuhiko Tamanoi; Loren G. Fong; Stephen G. Young
        JOURNAL OF LIPID RESEARCH, 2009年01月, 査読有り
      • Silica nanoparticles as a delivery system for nucleic acid-based reagents
        Christopher Hom; Jie Lu; Fuyuhiko Tamanoi
        JOURNAL OF MATERIALS CHEMISTRY, 2009年, 査読有り
      • Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery
        Yaroslav Klichko; Monty Liong; Eunshil Choi; Sarah Angelos; Andre E. Nel; J. Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I. Zink
        JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2009年01月, 査読有り
      • 栄養・代謝・成長から高次機能へ TOR経路研究の最前線 Rheb small G proteinによるmTORの活性化機構
        佐藤 龍洋; 玉野井 冬彦
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2008年11月
      • AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27
        John D. Short; Kevin D. Houston; Ruhee Dere; Sheng-Li Cai; Jinhee Kim; Charles L. Johnson; Russell R. Broaddus; Jianjun Shen; Susie Miyamoto; Fuyuhiko Tamanoi; David Kwiatkowski; Gordon B. Mills; Cheryl Lyn Walker
        CANCER RESEARCH, 2008年08月, 査読有り
      • Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
        Monty Liong; Jie Lu; Michael Kovochich; Tian Xia; Stefan G. Ruehm; Andre E. Nel; Fuyuhiko Tamanoi; Jeffrey I. Zink
        ACS NANO, 2008年05月, 査読有り
      • Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds
        Masaru Watanabe; Hannah D. G. Fiji; Lea Guo; Lai Chan; Sape S. Kinderman; Dennis J. Slamon; Ohyun Kwon; Fuyuhiko Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2008年04月, 査読有り
      • Light-activated nanoimpeller-controlled drug release in cancer cells
        Jie Lu; Eunshil Choi; Fuyuhiko Tamanoi; Jeffrey I. Zink
        SMALL, 2008年04月, 査読有り
      • Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control
        Kyoko Ikeda; Susumu. Morigasaki; Hisashi Tatebe; Fuyuhiko Tamanoi; Kazuhiro Shiozaki; These authors contributed equally to this wor
        Cell Cycle, 2008年02月, 査読有り
      • Characterization of the Rheb-mTOR signaling pathway in mammalian cells: Constitutive active mutants of Rheb and mTOR
        Tatsuhiro Sato; Akiko Umetsu; Fuyuhiko Tamanoi
        SMALL GTPASES IN DISEASE, PART A, 2008年, 査読有り
      • Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
        Jie Lu; Monty Liong; Jeffrey I. Zink; Fuyuhiko Tamanoi
        SMALL, 2007年08月, 査読有り
      • The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells
        Paul-Joseph Aspuria; Tatsuhiro Sato; Fuyuhiko Tamanoi
        CELL CYCLE, 2007年07月, 査読有り
      • Small-molecule inhibitors of protein geranylgeranyltransferase type I
        Sabrina Castellano; Hannah D. G. Fiji; Sape S. Kinderman; Masaru Watanabe; Pablo de Leon; Fuyuhiko Tamanoi; Ohyun Kwon
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007年05月, 査読有り
      • Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.
        Lu J; Liong M; Sherman S; Xia T; Kovochich M; Nel AE; Zink JI; Tamanoi F
        Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences, 2007年05月, 査読有り
      • Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
        Tomohiko Matsuo; Yoko Otsubo; Jun Urano; Fuyuhiko Tamanoi; Masayuki Yamamoto
        MOLECULAR AND CELLULAR BIOLOGY, 2007年04月, 査読有り
      • Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
        Jun Urano; Tatsuhiro Sato; Tomohiko Matsuo; Yoko Otsubo; Masayuki Yamamoto; Fuyuhiko Tamanoi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007年02月, 査読有り
      • Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress
        Parthive H. Patel; Fuyuhiko Tamanoi
        JOURNAL OF CELL SCIENCE, 2006年10月, 査読有り
      • Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
        J Urano; MJ Comiso; L Guo; PJ Aspuria; R Deniskin; AP Tabancay; J Kato-Stankiewicz; F Tamanoi
        MOLECULAR MICROBIOLOGY, 2005年11月, 査読有り
      • Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways
        CL Gau; J Kato-Stankiewicz; C Jiang; S Miyamoto; L Guo; F Tamanoi
        MOLECULAR CANCER THERAPEUTICS, 2005年06月, 査読有り
      • Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
        AP Tabancay; CL Gau; IMP Machado; EJ Uhlmann; DH Gutmann; L Guo; F Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2003年10月, 査読有り
      • Drosophila Rheb GTPase is required for cell cycle progression and cell growth
        PH Patel; N Thapar; L Guo; M Martinez; J Maris; CL Gau; JA Lengyel; F Tamanoi
        JOURNAL OF CELL SCIENCE, 2003年09月, 査読有り
      • A Novel Metal-Chelating Inhibitor of Protein Farnesyltransferase
        Akiyuki Hamasaki; Hayato Naka; Fuyuhiko Tamanoi; Kazuo Umezawa; Masami Otsuka
        Bioorganic and Medicinal Chemstry Letters, 2003年05月05日
      • Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
        J Kato-Stankiewicz; Hakimi, I; G Zhi; J Zhang; Serebriiskii, I; L Guo; H Edamatsu; H Koide; S Menon; R Eckl; S Sakamuri; YC Lu; QZ Chen; S Agarwal; WR Baumbach; EA Golemis; F Tamanoi; Khazak, V
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002年10月, 査読有り
      • RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
        BS Finlin; CL Gau; GA Murphy; HP Shao; T Kimel; RS Seitz; YF Chiu; D Botstein; PO Brown; F Tamanoi; DA Andres; CM Perou
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2001年11月, 査読有り
      • Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: Implications in breast cancer
        S Pervin; R Singh; CL Gau; H Edamatsu; F Tamanoi; G Chaudhuri
        CANCER RESEARCH, 2001年06月, 査読有り
      • Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines
        H Edamatsu; CL Gau; T Nemoto; L Guo; F Tamanoi
        ONCOGENE, 2000年06月, 査読有り
      • The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
        J Urano; AP Tabancay; WL Yang; F Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2000年04月, 査読有り
      • Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe
        WL Yang; J Urano; F Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2000年01月, 査読有り
      • A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors
        K Del Villar; J Urano; L Guo; F Tamanoi
        JOURNAL OF BIOLOGICAL CHEMISTRY, 1999年09月, 査読有り
      • Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70
        Nicole G. G. Robinson; Lea Guo; Jun Imai; Akio Toh-E; Yasushi Matsui; Fuyuhiko Tamanoi
        Molecular and Cellular Biology, 1999年05月, 査読有り
      • Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
        N Suzuki; J Urano; F Tamanoi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998年12月, 査読有り
      • Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents
        N Suzuki; K Del Villar; F Tamanoi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998年09月, 査読有り
      • Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I
        Keith Del Villar; Hiroshi Mitsuzawa; Wenli Yang; Isabel Sattler; Fuyuhiko Tamanoi
        Journal of Biological Chemistry, 1997年, 査読有り
      • Advances in the development of farnesyltransferase inhibitors: Substrate recognition by protein farnesyltransferase
        Wenli Yang; Keith Del Villar; Jun Urano; Hiroshi Mitsuzawa; Fuyuhiko Tamanoi
        Journal of Cellular Biochemistry, 1997年, 査読有り
      • C-terminal motifs found in Ras-superfamily G-proteins: CAAX and C-seven motifs
        K. Del Villar; D. Dorin; I. Sattler; J. Urano; P. Poullet; N. Robinson; H. Mitsuzawa; F. Tamanoi
        Biochemical Society Transactions, 1996年, 査読有り
      • Kir, a novel ras-family G-protein, induces invasive pseudohyphal growth in Saccharomyces cerevisiae
        D Dorin; L Cohen; K DelVillar; P Poullet; R Mohr; M Whiteway; O Witte; F Tamanoi
        ONCOGENE, 1995年12月, 査読有り
      • MUTANT FARNESYLTRANSFERASE BETA-SUBUNIT OF SACCHAROMYCES-CEREVISIAE THAT CAN SUBSTITUTE FOR GERANYLGERANYLTRANSFERASE TYPE-I BETA-SUBUNIT
        H MITSUZAWA; K ESSON; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995年02月, 査読有り
      • GapIII, a new brain‐enriched member of the GTPase‐activating protein family
        H. Baba; B. Fuss; J. Urano; P. Poullet; J. B. Watson; F. Tamanoi; W. B. Macklin
        Journal of Neuroscience Research, 1995年, 査読有り
      • TRANSCRIPTIONAL ACTIVATION OF A RAS-LIKE GENE (KIR) BY ONCOGENIC TYROSINE KINASES
        L COHEN; R MOHR; YY CHEN; M HUANG; R KATO; D DORIN; F TAMANOI; A GOGA; D AFAR; N ROSENBERG; O WITTE
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994年12月, 査読有り
      • BIOCHEMICAL-CHARACTERIZATION OF YEAST RAS2 MUTANTS REVEALS A NEW REGION OF RAS PROTEIN INVOLVED IN THE INTERACTION WITH GTPASE-ACTIVATING PROTEINS
        DR WOOD; P POULLET; BA WILSON; M KHALIL; K TANAKA; JF CANNON; F TAMANOI
        JOURNAL OF BIOLOGICAL CHEMISTRY, 1994年02月, 査読有り
      • IDENTIFICATION OF RAS FARNESYLTRANSFERASE INHIBITORS BY MICROBIAL SCREENING
        M HARA; K AKASAKA; S AKINAGA; M OKABE; H NAKANO; R GOMEZ; D WOOD; M UH; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993年03月, 査読有り
      • TERMINAL REGION RECOGNITION FACTOR-I, A DNA-BINDING PROTEIN RECOGNIZING THE INVERTED TERMINAL REPEATS OF THE PGK1 LINEAR DNA PLASMIDS
        DG MCNEEL; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991年12月, 査読有り
      • S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation
        Asao Fujiyama; Susumu Tsunasawa; Fuyuhiko Tamanoi; Fumio Sakiyama
        Journal of Biological Chemistry, 1991年09月25日, 査読有り
      • YEAST CAL1 IS A STRUCTURAL AND FUNCTIONAL HOMOLOG TO THE DPR1 (RAM) GENE INVOLVED IN RAS PROCESSING
        Y OHYA; M GOEBL; LE GOODMAN; S PETERSENBJORN; JD FRIESEN; F TAMANOI; Y ANRAKU
        JOURNAL OF BIOLOGICAL CHEMISTRY, 1991年07月, 査読有り
      • PROTEIN GERANYLGERANYLTRANSFERASE OF SACCHAROMYCES-CEREVISIAE IS SPECIFIC FOR CYS-XAA-XAA-LEU MOTIF PROTEINS AND REQUIRES THE CDC43 GENE-PRODUCT BUT NOT THE DPR1 GENE-PRODUCT
        AA FINEGOLD; DI JOHNSON; CC FARNSWORTH; MH GELB; JUDD, SR; JA GLOMSET; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991年05月, 査読有り
      • IRA2, AN UPSTREAM NEGATIVE REGULATOR OF RAS IN YEAST, IS A RAS GTPASE-ACTIVATING PROTEIN
        K TANAKA; BK LIN; DR WOOD; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991年01月, 査読有り
      • MUTANTS OF SACCHAROMYCES-CEREVISIAE DEFECTIVE IN THE FARNESYLATION OF RAS PROTEINS
        LE GOODMAN; JUDD, SR; CC FARNSWORTH; S POWERS; MH GELB; JA GLOMSET; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990年12月, 査読有り
      • RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus
        Asao Fujiyama; Fuyuhiko Tamanoi
        Journal of Biological Chemistry, 1990年02月25日, 査読有り
      • IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein
        K. Tanaka; M. Nakafuku; F. Tamanoi; Y. Kaziro; K. Matsumoto; E. A. Toh
        Molecular and Cellular Biology, 1990年, 査読有り
      • PHOSPHORYLATION OF RAS1 AND RAS2 PROTEINS IN SACCHAROMYCES-CEREVISIAE
        AR COBITZ; EH YIM; WR BROWN; CM PEROU; F TAMANOI
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989年02月, 査読有り
      • Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localiation of ras proteins
        Lauri E. Goodman; Charles M. Perou; Asao Fujiyama; Fuyuhiko Tamanoi
        Yeast, 1988年, 査読有り
      • A NOVEL YEAST MUTANT DEFECTIVE IN THE PROCESSING OF RAS PROTEINS - ASSESSMENT OF THE EFFECT OF THE MUTATION ON PROCESSING STEPS
        A FUJIYAMA; K MATSUMOTO; F TAMANOI
        EMBO JOURNAL, 1987年01月, 査読有り
      • ANALYSIS OF THE TRANSFORMING POTENTIAL OF THE HUMAN H-RAS GENE BY RANDOM MUTAGENESIS
        O FASANO; T ALDRICH; F TAMANOI; E TAPAROWSKY; M FURTH; M WIGLER
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984年, 査読有り
      • A PRODUCT OF YEAST RAS2 GENE IS A GUANINE-NUCLEOTIDE BINDING-PROTEIN
        F TAMANOI; M WALSH; T KATAOKA; M WIGLER
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984年, 査読有り
      • INITIATION OF ADENOVIRUS DNA-REPLICATION INVITRO REQUIRES A SPECIFIC DNA-SEQUENCE
        F TAMANOI; BW STILLMAN
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983年, 査読有り
      • REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIOBONUCLEIC ACID .21. INITIATION OF DNA-REPLICATION AT THE PRIMARY ORIGIN OF BACTERIOPHAGE-T7 BY PURIFIED PROTEINS - REQUIREMENT FOR T7 RNA-POLYMERASE
        LJ ROMANO; F TAMANOI; CC RICHARDSON
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981年, 査読有り
      • REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIBONUCLEIC-ACID .17. PHYSICAL MAPPING OF PRIMARY AND SECONDARY ORIGINS OF BACTERIOPHAGE-T7 DNA-REPLICATION
        F TAMANOI; H SAITO; CC RICHARDSON
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980年, 査読有り
      • REPLICATION OF BACTERIOPHAGE-T7 DEOXYRIBONUCLEIC-ACID .18. NUCLEOTIDE-SEQUENCE OF THE PRIMARY ORIGIN OF BACTERIOPHAGE-T7 DNA-REPLICATION - RELATIONSHIP TO ADJACENT GENES AND REGULATORY ELEMENTS
        H SAITO; S TABOR; F TAMANOI; CC RICHARDSON
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980年, 査読有り

      MISC

      • がんの鶏卵モデル
        小松葵; 松本光太郎; 玉野井冬彦
        患者由来のがんモデルを用いたがん研究実践ガイド, 2019年10月
      • Treatment of metastatic breast cancer using two nanoparticles combined with siRNA targeting Twist1 to inhibit EMT
        James B. Finlay; Cai M. Roberts; Gina Lowe; Ling Peng; Jeff I. Zink; Fuyuhiko Tamanoi; Carlotta A. Glackin
        CANCER RESEARCH, 2015年05月
      • Interruption of K-Ras/PAK1/Crk pathway has a dramatic anti-tumor effect in NSCLC
        Fariborz (Fred) Mortazavi; Jie Lu; Aljilani Amir; Ryan Phan; Fuyuhiko Tamanoi
        MOLECULAR CANCER RESEARCH, 2014年12月
      • Light-controllable nano-drug delivery system with deep tissue penetrating ability for cancer therapy with two-photon-triggered nanoimpellers
        Jie Lu; Jonas Croissant; Jean-Olivier Jean-Olivier Durand; Tania Guardado-Alvarez; Jeffrey I. Zink; Fuyuhiko Tamanoi
        CANCER RESEARCH, 2014年10月
      • Recent progress in the study of the Rheb family GTPases
        Jeffrey J. Heard; Valerie Fong; S. Zahra Bathaie; Fuyuhiko Tamanoi
        CELLULAR SIGNALLING, 2014年09月
      • Nanomachine-controlled cargo release monitored in single living cells
        Bryana L. Henderson; Yuen A. Lau; Eunshil Choi; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I. Zink
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011年03月
      • Real-time rate measurement of cargo release by nanoimpellers in a single cell
        Yuen A. Lau; Bryana Henderson; Jie Lu; Fuyuhiko Tamanoi; Jeff I. Zink
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011年03月
      • Conservation of the Tsc/Rheb/TORC1/S6K/S6 signaling in fission yeast
        Akio Nakashima; Fuyuhiko Tamanoi
        Enzymes, 2010年, 招待有り
      • Blocking Rheb posttranslational processing and localization for cancer treatment
        Ariella Hanker; Rhonda Wilder; Elizabeth Henske; Fuyuhiko Tamanoi; Adrienne Cox; Channing Der
        CANCER RESEARCH, 2009年05月
      • In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase I
        Jie Lu; Lai Chan; Hannah Fiji; Russell Dahl; Ohyun Kwon; Fuyuhiko Tamanoi
        CANCER RESEARCH, 2009年05月
      • Chemical biology/chemical genetics/chemical genomics: Importance of chemical library
        Fumihiko Kugawa; Masaru Watanabe; Fuyuhiko Tamanoi
        Chem-Bio Informatics Journal, 2007年
      • NEW ACTIVATED RAS2 MUTATIONS IDENTIFIED IN SACCHAROMYCES-CEREVISIAE
        BA WILSON; M KHALIL; F TAMANOI; JF CANNON
        ONCOGENE, 1993年12月

      講演・口頭発表等

      • Gadolinium-loaded mesoporous silica nanoparticles trigger destruction of tumor spheroids upon irradiation with monochromatic X-ray
        Yue Ma; Fuyuhiko Tamanoi
        The 8th Japan-China Symposium on Nanomedicine, 2021年06月11日, 招待有り
      • A new radiation therapy by combining gadolinium-loaded nanoparticles and monochromatic X-ray
        Fuyuhiko Tamanoi
        E-MRS Spring meeting 2021, 2021年06月03日, 招待有り
      • 量子ビームとナノ材料研究により拓かれる量子ナノ医療研究
        玉野井冬彦
        ナノ学会第18回大会, 2020年05月
      • Nanomedicine and Cancer Therapy
        Fuyuhiko Tamanoi
        Kyoto University-Academia Sinica Bilateral Symposium, 2019年12月18日, 招待有り
      • Novel radiation therapy employing monochromatic X-ray and nanoparticles
        Fuyuhiko Tamanoi
        First QNM-iCeMS Symposium: Exploring New Approaches for Cancer Therapy, 2019年12月13日, 招待有り
      • Developing a Novel radiation therapy involving monochromatic X-ray and Auger effect
        Fuyuhiko Tamanoi
        13th International Symposium on Nanomedicine, 2019年12月06日, 招待有り
      • Developing a novel radiation therapy by employing monochromatic X-ray and nanoparticles
        Fuyuhiko Tamanoi
        International Symposium: New Technology for Diagnosis and Therapeutics of Cancer, 2019年12月02日, 招待有り
      • Chicken egg tumor model and boron neutron capture therapy (BNCT)
        Fuyuhiko Tamanoi
        Annual Retreat, Kyoto University, 2019年09月22日, 招待有り
      • A new radiation therapy emerging from the convergence of nanotechnology and particle physics
        Fuyuhiko Tamanoi
        HeKKSaGOn 6th German-Japanese University Presidents’ Conference, 2019年09月12日, 招待有り
      • Patient-derived chicken egg tumor model (PDcE model)
        玉野井冬彦
        講演会：患者由来がんモデル～基礎研究から臨床応用まで～, 2019年08月02日, 招待有り
      • Patient-derived tumor models and KRAS inhibitors
        Fuyuhiko Tamanoi
        FASEB Summer Research Conference, 2019年06月24日, 招待有り
      • Efficacy of biodegradable PMO to inhibit tumor growth in animal models
        Fuyuhiko Tamanoi
        The 7th China-Japan Symposium on Nanomedicine, 2019年05月25日, 招待有り
      • Patient-derived Chicken Egg Tumor Model, Precision Medicine and Nanoparticle-mediated Cancer Therapy
        玉野井 冬彦
        Kyoto Winter School "Quantifying Dynamics of Life", 2019年03月26日, 招待有り
      • Patient-derived chicken egg tumor modeland tailor-made medicine
        玉野井 冬彦
        The SPIRITS International Symposium-2019 "Regulation of cell fate and disease treatment", 2019年01月28日, 招待有り
      • Tumor Targeting of Mesoporous Silica Nanoparticles Characterized by Using Chicken Egg Tumor Model
        玉野井 冬彦
        2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine, 2018年12月14日, 招待有り
      • Boron Neutron Capture Therapy and Nanotechnology
        玉野井 冬彦
        12th International Symposium on Nanomedicine, 2018年12月07日
      • Boron Neutron Capture Therapy and Nanotechnology
        玉野井 冬彦
        Kyoto-UCLA, Harnessing Physical Forces for Medical Applocations Symposium, 2018年11月
      • 癌の鶏卵モデル：患者由来がんモデルとナノ治療開発系としての可能性
        玉野井 冬彦
        新しい治療法の開発を目指す患者由来がんモデル, 2018年06月28日, 招待有り
      • Cancer therapy using mesoporous silica nanoparticles
        玉野井 冬彦
        Mesoporous Materials: 1991-2018. International Symposium, 2018年04月10日, 招待有り

      外部資金：科学研究費補助金

      • 単色X線とナノ粒子を用いたがんの新規放射線治療
        基盤研究(A)
        中区分28:ナノマイクロ科学およびその関連分野
        京都大学
        玉野井 冬彦
        自 2020年04月01日, 至 2023年03月31日, 完了
        高Z元素;単色X線;ナノ粒子;がんスフェロイド;DNA二重鎖切断;ヨウ素含有DNA結合色素;オージェ治療;アポトーシス;オージェ電子;K端エネルギー;オージェ効果;高Z元素担持ナノ粒子;マウス実験;単色Ｘ線;高Ｚ元素;Auger効果
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00331/
      • 新規のホウ素含有ナノ粒子の構築とBNCTへの応用
        国際共同研究加速基金(帰国発展研究)
        京都大学
        玉野井 冬彦
        自 2017年04月01日, 至 2020年03月31日, 完了
        メソポーラスシリカナノ粒子;がん蓄積;がんの鶏卵モデル;がんスフェロイド;ホウ素中性子捕捉療法;単色X線;オージェ効果;ホウ素含有メソポーラスシリカナノ粒子;鶏卵のがんモデル;がんへの蓄積;癌へのターゲティング;鶏卵の癌モデル;ナノ材料;ナノバイオ;放射線
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21764/

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