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Thumkeo, Dean

Graduate School of Medicine Professor

Thumkeo, Dean
list
    Last Updated :2025/01/21

    Basic Information

    Faculty

    • Institute for Liberal Arts and Sciences (ILAS)
    • 医学部

    Academic Degree

    • 修士(生命科学)(京都大学)
    • 博士(医学)(京都大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2025/01/21

      Research

      Research Topics, Overview of the research

      • Research Topics

        マウス個体発生におけるROCKの機能解明、神経幹細胞におけるRho-mDiaシグナルの役割解明、T細胞形態形成におけるmDia1/3の機能解析

      Research Areas

      • Life sciences, Pharmacology

      Papers

      • Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice
        Takahiro Akamine; Takeshi Terabayashi; Takako Sasaki; Riku Hayashi; Ichitaro Abe; Fumihiro Hirayama; Shin-ichi Nureki; Masahito Ikawa; Haruhiko Miyata; Akinori Tokunaga; Takashi Kobayashi; Katsuhiro Hanada; Dean Thumkeo; Shuh Narumiya; Toshimasa Ishizaki
        FEBS Open Bio, Apr. 2024, Peer-reviewed
      • T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.
        Jinju Lee; Tomohiro Aoki; Dean Thumkeo; Ratklao Siriwach; Chengcan Yao; Shuh Narumiya
        The Journal of allergy and clinical immunology, Feb. 2019, Peer-reviewed
      • Roles of mDia isoforms, a Rho effector, in neuroblast migration
        Ryota Shinohara; Dean Thumkeo; Hiroshi Kamijo; Naoko Kaneko; Kazunobu Sawamoto; Keisuke Watanabe; Hirohide Takebayashi; Toshimasa Ishizaki; Tomoyuki Furuyashiki; Shuh Narumiya
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Peer-reviewed
      • mDia, an actin nucleator and a Rho effector, is critical for tangential migration of cortical and olfactory bulb inhibitory interneuron precursors
        Ryota Shinohara; Dean Thumkeo; Hiroshi Kamijo; Naoko Kaneko; Kazunobu Sawamoto; Keisuke Watanabe; Hirohide Takebayashi; Hiroshi Kiyonari; Toshimasa Ishizaki; Tomoyuki Furuyashiki; Shuh Narumiya
        NEUROSCIENCE RESEARCH, 2011, Peer-reviewed
      • Roles of mDia isoforms, a Rho effector, in neural development
        Ryota Shinohara; Dean Thumkeo; Hiroshi Kamijo; Naoko Kaneko; Kazunobu Sawamoto; Hiroyuki Hioki; Takeshi Kaneko; Keisuke Watanabe; Hirohide Takebayashi; Toshimasa Ishizaki; Tomoyuki Furuyashiki; Shuh Narumiya
        NEUROSCIENCE RESEARCH, 2010, Peer-reviewed
      • An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis.
        Ratklao Siriwach; Anh Quynh Ngo; Shuh Narumiya; Dean Thumkeo
        STAR protocols, 16 Dec. 2022
      • PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.
        Dean Thumkeo; Siwakorn Punyawatthananukool; Somsak Prasongtanakij; Ryuma Matsuura; Kentaro Arima; Huan Nie; Rie Yamamoto; Naohiro Aoyama; Hisao Hamaguchi; Shingo Sugahara; Shinobu Takeda; Varodom Charoensawan; Atsushi Tanaka; Shimon Sakaguchi; Shuh Narumiya
        Cell reports, 07 Jun. 2022
      • Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing.
        Ratklao Siriwach; Anh Quynh Ngo; Makio Higuchi; Kentaro Arima; Satoko Sakamoto; Akira Watanabe; Shuh Narumiya; Dean Thumkeo
        iScience, 15 Apr. 2022
      • LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.
        Kimberly N Kremer; Alan Buser; Dean Thumkeo; Shuh Narumiya; Jordan Jacobelli; Roberta Pelanda; Raul M Torres
        Proceedings of the National Academy of Sciences of the United States of America, 12 Apr. 2022
      • DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.
        Adam J Kundishora; Samuel T Peters; Amélie Pinard; Daniel Duran; Shreyas Panchagnula; Tanyeri Barak; Danielle F Miyagishima; Weilai Dong; Hannah Smith; Jack Ocken; Ashley Dunbar; Carol Nelson-Williams; Shozeb Haider; Rebecca L Walker; Boyang Li; Hongyu Zhao; Dean Thumkeo; Arnaud Marlier; Phan Q Duy; Nicholas S Diab; Benjamin C Reeves; Stephanie M Robert; Nanthiya Sujijantarat; Amber N Stratman; Yi-Hsien Chen; Shujuan Zhao; Isabelle Roszko; Qiongshi Lu; Bo Zhang; Shrikant Mane; Christopher Castaldi; Francesc López-Giráldez; James R Knight; Michael J Bamshad; Deborah A Nickerson; Daniel H Geschwind; Shih-Shan Lang Chen; Phillip B Storm; Michael L Diluna; Charles C Matouk; Darren B Orbach; Seth L Alper; Edward R Smith; Richard P Lifton; Murat Gunel; Dianna M Milewicz; Sheng Chih Jin; Kristopher T Kahle
        JAMA neurology, 01 Aug. 2021
      • Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction.
        Ichitaro Abe; Takeshi Terabayashi; Katsuhiro Hanada; Hidekazu Kondo; Yasushi Teshima; Yumi Ishii; Miho Miyoshi; Shintaro Kira; Shotaro Saito; Hirotsugu Tsuchimochi; Mikiyasu Shirai; Kunio Yufu; Motoki Arakane; Tsutomu Daa; Dean Thumkeo; Shuh Narumiya; Naohiko Takahashi; Toshimasa Ishizaki
        Cardiovascular research, 21 Mar. 2021
      • Opening the Door to Better Aspirin.
        Dean Thumkeo; Shuh Narumiya
        Structure (London, England : 1993), 04 Mar. 2021
      • DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation.
        Ronen Schneider; Konstantin Deutsch; Gregory J Hoeprich; Jonathan Marquez; Tobias Hermle; Daniela A Braun; Steve Seltzsam; Thomas M Kitzler; Youying Mao; Florian Buerger; Amar J Majmundar; Ana C Onuchic-Whitford; Caroline M Kolvenbach; Luca Schierbaum; Sophia Schneider; Abdul A Halawi; Makiko Nakayama; Nina Mann; Dervla M Connaughton; Verena Klämbt; Matias Wagner; Korbinian M Riedhammer; Lutz Renders; Yoshichika Katsura; Dean Thumkeo; Neveen A Soliman; Shrikant Mane; Richard P Lifton; Shirlee Shril; Mustafa K Khokha; Julia Hoefele; Bruce L Goode; Friedhelm Hildebrandt
        American journal of human genetics, 03 Dec. 2020
      • mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
        D Thumkeo; Y Katsura; Y Nishimura; P Kanchanawong; K Tohyama; T Ishizaki; S Kitajima; C Takahashi; T Hirata; N Watanabe; M F Krummel; S Narumiya
        Science advances, Jan. 2020, Peer-reviewed
      • LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.
        Akiko Sumitomo; Ratklao Siriwach; Dean Thumkeo; Kentaro Ito; Ryota Nakagawa; Nobuo Tanaka; Kohei Tanabe; Akira Watanabe; Mari Kishibe; Akemi Ishida-Yamamoto; Tetsuya Honda; Kenji Kabashima; Junken Aoki; Shuh Narumiya
        The Journal of investigative dermatology, May 2019
      • mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.
        Sakamoto S; Thumkeo D; Ohta H; Zhang Z; Huang S; Kanchanawong P; Fuu T; Watanabe S; Shimada K; Fujihara Y; Yoshida S; Ikawa M; Watanabe N; Saitou M; Narumiya S
        PLoS biology, Sep. 2018, Peer-reviewed
      • Moesin controls clathrin-mediated S1PR1 internalization in T cells.
        Nomachi A; Yoshinaga M; Liu J; Kanchanawong P; Tohyama K; Thumkeo D; Watanabe T; Narumiya S; Hirata T
        PloS one, Dec. 2013, Peer-reviewed
      • EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.
        Toyoda Y; Shinohara R; Thumkeo D; Kamijo H; Nishimaru H; Hioki H; Kaneko T; Ishizaki T; Furuyashiki T; Narumiya S
        Genes Cells, Oct. 2013, Peer-reviewed
      • A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
        Shinohara R; Thumkeo D; Kamijo H; Kaneko N; Sawamoto K; Watanabe K; Takebayashi H; Kiyonari H; Ishizaki T; Furuyashiki T; Narumiya S
        Nature Neurosci, Jan. 2012, Peer-reviewed
      • 453. Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.
        Kamijo H; Matsumura Y; Thumkeo D; Koike S; Masu M; Shimizu Y; Ishizaki T; Narumiya S
        455. Genes Cells 16, 1012-1021., Oct. 2011, Peer-reviewed
      • Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
        Thumkeo D; Shinohara R; Watanabe K; Takebayashi H; Toyoda Y; Tohyama K; Ishizaki T; Furuyashiki T; Narumiya S
        PLoS One, Sep. 2011, Peer-reviewed
      • Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death
        D Thumkeo; J Keel; T Ishizaki; M Hirose; K Nonomura; H Oshima; M Oshima; MM Taketo; S Narumiya
        MOLECULAR AND CELLULAR BIOLOGY, Jul. 2003
      • ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
        D Thumkeo; Y Shimizu; S Sakamoto; S Yamada; S Narumiya
        GENES TO CELLS, Aug. 2005
      • ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
        Y Shimizu; D Thumkeo; J Keel; T Ishizaki; H Oshima; M Oshima; Y Noda; F Matsumura; MM Taketo; S Narumiya
        JOURNAL OF CELL BIOLOGY, Mar. 2005

      Misc.

      • Roles of mDia1/3 in neuroepithelium integrity and neuroblast migration
        D. Thumkeo; R. Shinohara; S. Narumiya
        MOLECULAR BIOLOGY OF THE CELL, 2015
      • Rho signaling in developing nervous system
        Dean Thumkeo; Ryota Shinohara; Shuh Narumiya
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
      • Rho signaling research: history, current status and future directions
        Shuh Narumiya; Dean Thumkeo
        FEBS Letters, 01 Jun. 2018
      • Targeted disruption of the Rho-associated kinase 2 (mROCK-II) gene results in intrauterine growth retardation and fetal death
        D Thumkeo; T Ishizaki; J Keel; K Kimura; M Oshima; MM Taketo; S Narumiya
        MOLECULAR BIOLOGY OF THE CELL, Nov. 2002
      • ROCKの個体初期発生における役割
        上條博史; 松村裕; THUMKEO Dean; 清水良彦; 寺尾円香; 石崎敏理; 成宮周
        生化学, 2007

      External funds: Kakenhi

      • Elucidation of the molecular mechanism of T cell subcortical actin formation and its role in TCR signaling
        Grant-in-Aid for Scientific Research (C)
        Basic Section 48030:Pharmacology-related
        Kyoto University
        Dean Thumkeo
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        T細胞;アクチン;formin;皮質下;T細胞受容体シグナル
      • Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumor
        Grant-in-Aid for Scientific Research (C)
        Basic Section 56010:Neurosurgery-related
        Kyoto University
        Yoshiki Arakawa
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        非定型奇形腫様ラブドイド腫瘍;リプログラミング;ヒト人工多能性幹細胞;エピゲノム異常;INI-1;SMARCB1;RAD21;iPS;AT/RT;転写ネットワーク;iPS;iPS細胞;エピゲノム
      • Role of mDia, a polymerization factor, in Treg differentiation
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Dean Thumkeo
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        制御性T細胞;アクチン細胞骨格;mDia;Treg;免疫寛容;薬理学;免疫学;細胞・組織
      • Epigenomic analysis with reprogramming technology in lower grade glioma
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Yoshiki Arakawa
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        低悪性度グリオーマ;ダイレクトリプログラミング;エピゲノム異常;分化誘導;脳腫瘍;グリオーマ;エピゲノム;iPS;リプログラミング
      • Analysis of TCR signaling dependent mDia activation molecular mechanism
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Dean Thumkeo
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        T細胞;mDia;TCRシグナル;アクチン;免疫抑制剤;低分子量G蛋白質
      • Molecular mechanism of mDia function in T cell activation
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Dean THUMKEO
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        TCRシグナル;mDia;F-actin;T細胞;免疫抑制剤;アクチン
      • Analysis of antitumor immunity induced by vaccinia virus with in vivo imaging
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Yoshiki Arakawa
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        悪性脳腫瘍;ワクシニアウイルス;生体イメージング;腫瘍免疫;免疫誘導;ウイルス治療;悪性グリオーマ
      • Elucidation of the role and mechanism of action of prostaglandin E2 in cancer though the immune suppression activity of Treg cells
        Grant-in-Aid for Scientific Research (C)
        Basic Section 48030:Pharmacology-related
        Kyoto University
        Thumkeo Dean
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        PGE2;Treg;免疫抑制;がん
      list
        Last Updated :2025/01/21

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Biochemistry-E2
          N490, Fall, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          ILAS Seminar-E2
          Z002, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Principles of Genetics-E2
          N492, Spring, Institute for Liberal Arts and Sciences, 2

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