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Thumkeo, Dean
Graduate School of Medicine Professor
list
Last Updated :2026/06/19
Research
Research Topics, Overview of the research
Research Topics
マウス個体発生におけるROCKの機能解明、神経幹細胞におけるRho-mDiaシグナルの役割解明、T細胞形態形成におけるmDia1/3の機能解析
Research Areas
Papers
- Enhancing Immunotherapeutic Response in Colorectal Cancer with a Neuropilin 1–Targeting Tumor-Penetrating PeptideAtsushi Fukugaki; Shigeo Hisamori; Dean Thumkeo; Hotaka Kawai; Yugo Matsui; Yuki Teramoto; Yoshihisa Okuchi; Atsuhito Omori; Norio Miyamura; Yukihito Kuroda; Kazuki N. Sugahara; Kazutaka ObamaCancer Research Communications, 01 Jun. 2026
- Phenylalanine amide derivatives promote FLG expression via AHR activation in normal human epidermal keratinocytesAkiko Sumitomo; Ratklao Siriwach; Makio Higuchi; Quynh Anh Ngo; Nobuo Tanaka; Somsak Prasongtanakij; Dean Thumkeo; Shuh NarumiyaJournal of Pharmacological Sciences, Sep. 2025
- The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancersSomsak Prasongtanakij; Kitipong Soontrapa; Dean ThumkeoEuropean Journal of Cell Biology, Jun. 2025
- Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells.Siwakorn Punyawatthananukool; Ryuma Matsuura; Thamrong Wongchang; Nao Katsurada; Tatsuaki Tsuruyama; Masaki Tajima; Yutaka Enomoto; Toshio Kitamura; Masahiro Kawashima; Masakazu Toi; Koji Yamanoi; Junzo Hamanishi; Shigeo Hisamori; Kazutaka Obama; Varodom Charoensawan; Dean Thumkeo; Shuh NarumiyaNature communications, 01 Nov. 2024
- FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanismsAshton L. Sigler; Scott B. Thompson; Logan Ellwood-Digel; Adithan Kandasamy; Mary J. Michaels; Dean Thumkeo; Shuh Narumiya; Juan C. Del Alamo; Jordan JacobelliFrontiers in Immunology, 04 Oct. 2024
- Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent mannerTetsuya Watabe; Shinya Yamahira; Kanako Takakura; Dean Thumkeo; Shuh Narumiya; Michiyuki Matsuda; Kenta TeraieLife, 26 Jan. 2024
- Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune responseThamrong Wongchang; Panwadee Pluangnooch; Suradej Hongeng; Adisak Wongkajornsilp; Dean Thumkeo; Kitipong SoontrapaScientific Reports, 29 Apr. 2023
- Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss.Takehiko Ueyama; Yuzuru Ninoyu; Shin-Ya Nishio; Takushi Miyoshi; Hiroko Torii; Koji Nishimura; Kazuma Sugahara; Hideaki Sakata; Dean Thumkeo; Hirofumi Sakaguchi; Naoki Watanabe; Shin-Ichi Usami; Naoaki Saito; Shin-Ichiro KitajiriEMBO molecular medicine, Nov. 2016, Peer-reviewed
- Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult miceTakahiro Akamine; Takeshi Terabayashi; Takako Sasaki; Riku Hayashi; Ichitaro Abe; Fumihiro Hirayama; Shin-ichi Nureki; Masahito Ikawa; Haruhiko Miyata; Akinori Tokunaga; Takashi Kobayashi; Katsuhiro Hanada; Dean Thumkeo; Shuh Narumiya; Toshimasa IshizakiFEBS Open Bio, Apr. 2024, Peer-reviewed
- T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.Jinju Lee; Tomohiro Aoki; Dean Thumkeo; Ratklao Siriwach; Chengcan Yao; Shuh NarumiyaThe Journal of allergy and clinical immunology, Feb. 2019, Peer-reviewed
- An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis.Ratklao Siriwach; Anh Quynh Ngo; Shuh Narumiya; Dean ThumkeoSTAR protocols, 16 Dec. 2022
- PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.Dean Thumkeo; Siwakorn Punyawatthananukool; Somsak Prasongtanakij; Ryuma Matsuura; Kentaro Arima; Huan Nie; Rie Yamamoto; Naohiro Aoyama; Hisao Hamaguchi; Shingo Sugahara; Shinobu Takeda; Varodom Charoensawan; Atsushi Tanaka; Shimon Sakaguchi; Shuh NarumiyaCell reports, 07 Jun. 2022
- Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing.Ratklao Siriwach; Anh Quynh Ngo; Makio Higuchi; Kentaro Arima; Satoko Sakamoto; Akira Watanabe; Shuh Narumiya; Dean ThumkeoiScience, 15 Apr. 2022
- LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.Kimberly N Kremer; Alan Buser; Dean Thumkeo; Shuh Narumiya; Jordan Jacobelli; Roberta Pelanda; Raul M TorresProceedings of the National Academy of Sciences of the United States of America, 12 Apr. 2022
- DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.Adam J Kundishora; Samuel T Peters; Amélie Pinard; Daniel Duran; Shreyas Panchagnula; Tanyeri Barak; Danielle F Miyagishima; Weilai Dong; Hannah Smith; Jack Ocken; Ashley Dunbar; Carol Nelson-Williams; Shozeb Haider; Rebecca L Walker; Boyang Li; Hongyu Zhao; Dean Thumkeo; Arnaud Marlier; Phan Q Duy; Nicholas S Diab; Benjamin C Reeves; Stephanie M Robert; Nanthiya Sujijantarat; Amber N Stratman; Yi-Hsien Chen; Shujuan Zhao; Isabelle Roszko; Qiongshi Lu; Bo Zhang; Shrikant Mane; Christopher Castaldi; Francesc López-Giráldez; James R Knight; Michael J Bamshad; Deborah A Nickerson; Daniel H Geschwind; Shih-Shan Lang Chen; Phillip B Storm; Michael L Diluna; Charles C Matouk; Darren B Orbach; Seth L Alper; Edward R Smith; Richard P Lifton; Murat Gunel; Dianna M Milewicz; Sheng Chih Jin; Kristopher T KahleJAMA neurology, 01 Aug. 2021
- Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction.Ichitaro Abe; Takeshi Terabayashi; Katsuhiro Hanada; Hidekazu Kondo; Yasushi Teshima; Yumi Ishii; Miho Miyoshi; Shintaro Kira; Shotaro Saito; Hirotsugu Tsuchimochi; Mikiyasu Shirai; Kunio Yufu; Motoki Arakane; Tsutomu Daa; Dean Thumkeo; Shuh Narumiya; Naohiko Takahashi; Toshimasa IshizakiCardiovascular research, 21 Mar. 2021
- Opening the Door to Better Aspirin.Dean Thumkeo; Shuh NarumiyaStructure (London, England : 1993), 04 Mar. 2021
- DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation.Ronen Schneider; Konstantin Deutsch; Gregory J Hoeprich; Jonathan Marquez; Tobias Hermle; Daniela A Braun; Steve Seltzsam; Thomas M Kitzler; Youying Mao; Florian Buerger; Amar J Majmundar; Ana C Onuchic-Whitford; Caroline M Kolvenbach; Luca Schierbaum; Sophia Schneider; Abdul A Halawi; Makiko Nakayama; Nina Mann; Dervla M Connaughton; Verena Klämbt; Matias Wagner; Korbinian M Riedhammer; Lutz Renders; Yoshichika Katsura; Dean Thumkeo; Neveen A Soliman; Shrikant Mane; Richard P Lifton; Shirlee Shril; Mustafa K Khokha; Julia Hoefele; Bruce L Goode; Friedhelm HildebrandtAmerican journal of human genetics, 03 Dec. 2020
- mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.D Thumkeo; Y Katsura; Y Nishimura; P Kanchanawong; K Tohyama; T Ishizaki; S Kitajima; C Takahashi; T Hirata; N Watanabe; M F Krummel; S NarumiyaScience advances, Jan. 2020, Peer-reviewed
- LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.Akiko Sumitomo; Ratklao Siriwach; Dean Thumkeo; Kentaro Ito; Ryota Nakagawa; Nobuo Tanaka; Kohei Tanabe; Akira Watanabe; Mari Kishibe; Akemi Ishida-Yamamoto; Tetsuya Honda; Kenji Kabashima; Junken Aoki; Shuh NarumiyaThe Journal of investigative dermatology, May 2019
- mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.Sakamoto S; Thumkeo D; Ohta H; Zhang Z; Huang S; Kanchanawong P; Fuu T; Watanabe S; Shimada K; Fujihara Y; Yoshida S; Ikawa M; Watanabe N; Saitou M; Narumiya SPLoS biology, Sep. 2018, Peer-reviewed
- Moesin controls clathrin-mediated S1PR1 internalization in T cells.Nomachi A; Yoshinaga M; Liu J; Kanchanawong P; Tohyama K; Thumkeo D; Watanabe T; Narumiya S; Hirata TPloS one, Dec. 2013, Peer-reviewed
- EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.Toyoda Y; Shinohara R; Thumkeo D; Kamijo H; Nishimaru H; Hioki H; Kaneko T; Ishizaki T; Furuyashiki T; Narumiya SGenes Cells, Oct. 2013, Peer-reviewed
- A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.Shinohara R; Thumkeo D; Kamijo H; Kaneko N; Sawamoto K; Watanabe K; Takebayashi H; Kiyonari H; Ishizaki T; Furuyashiki T; Narumiya SNature Neurosci, Jan. 2012, Peer-reviewed
- 453. Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.Kamijo H; Matsumura Y; Thumkeo D; Koike S; Masu M; Shimizu Y; Ishizaki T; Narumiya S455. Genes Cells 16, 1012-1021., Oct. 2011, Peer-reviewed
- Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.Thumkeo D; Shinohara R; Watanabe K; Takebayashi H; Toyoda Y; Tohyama K; Ishizaki T; Furuyashiki T; Narumiya SPLoS One, Sep. 2011, Peer-reviewed
- Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal deathD Thumkeo; J Keel; T Ishizaki; M Hirose; K Nonomura; H Oshima; M Oshima; MM Taketo; S NarumiyaMOLECULAR AND CELLULAR BIOLOGY, Jul. 2003
- ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryoD Thumkeo; Y Shimizu; S Sakamoto; S Yamada; S NarumiyaGENES TO CELLS, Aug. 2005
- ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundlesY Shimizu; D Thumkeo; J Keel; T Ishizaki; H Oshima; M Oshima; Y Noda; F Matsumura; MM Taketo; S NarumiyaJOURNAL OF CELL BIOLOGY, Mar. 2005
Misc.
- Physiological roles of rho and rho effectors in mammalsDean Thumkeo; Sadanori Watanabe; Shuh NarumiyaEuropean Journal of Cell Biology, Oct. 2013
- Roles of mDia1/3 in neuroepithelium integrity and neuroblast migrationD. Thumkeo; R. Shinohara; S. NarumiyaMOLECULAR BIOLOGY OF THE CELL, 2015
- Rho signaling in developing nervous systemDean Thumkeo; Ryota Shinohara; Shuh NarumiyaJOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
- Rho signaling research: history, current status and future directionsShuh Narumiya; Dean ThumkeoFEBS Letters, 01 Jun. 2018
- Targeted disruption of the Rho-associated kinase 2 (mROCK-II) gene results in intrauterine growth retardation and fetal deathD Thumkeo; T Ishizaki; J Keel; K Kimura; M Oshima; MM Taketo; S NarumiyaMOLECULAR BIOLOGY OF THE CELL, Nov. 2002
- ROCKの個体初期発生における役割上條博史; 松村裕; THUMKEO Dean; 清水良彦; 寺尾円香; 石崎敏理; 成宮周生化学, 2007
External funds: Kakenhi
- 幹細胞様メモリーT細胞を中心とするがんにおけるPGE2の多層的免疫抑制機構の解明Grant-in-Aid for Scientific Research (B)Basic Section 48030:Pharmacology-relatedKyoto UniversityThumkeo DeanFrom 01 Apr. 2026, To 31 Mar. 2029, Adopted
- Elucidation of the molecular mechanism of T cell subcortical actin formation and its role in TCR signalingGrant-in-Aid for Scientific Research (C)Basic Section 48030:Pharmacology-relatedKyoto UniversityDean ThumkeoFrom 01 Apr. 2020, To 31 Mar. 2023, Project ClosedT細胞;アクチン;formin;皮質下;T細胞受容体シグナル
- Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumorGrant-in-Aid for Scientific Research (C)Basic Section 56010:Neurosurgery-relatedKyoto UniversityYoshiki ArakawaFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed非定型奇形腫様ラブドイド腫瘍;リプログラミング;ヒト人工多能性幹細胞;エピゲノム異常;INI-1;SMARCB1;RAD21;ｉＰＳ;AT/RT;転写ネットワーク;iPS;iPS細胞;エピゲノム
- Role of mDia, a polymerization factor, in Treg differentiationGrant-in-Aid for Scientific Research (C)Kyoto UniversityDean ThumkeoFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closed制御性T細胞;アクチン細胞骨格;mDia;Treg;免疫寛容;薬理学;免疫学;細胞・組織
- Epigenomic analysis with reprogramming technology in lower grade gliomaGrant-in-Aid for Scientific Research (C)Kyoto UniversityYoshiki ArakawaFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closed低悪性度グリオーマ;ダイレクトリプログラミング;エピゲノム異常;分化誘導;脳腫瘍;グリオーマ;エピゲノム;iPS;リプログラミング
- Analysis of TCR signaling dependent mDia activation molecular mechanismGrant-in-Aid for Young Scientists (B)Kyoto UniversityDean ThumkeoFrom 01 Apr. 2015, To 31 Mar. 2017, Project ClosedT細胞;mDia;TCRシグナル;アクチン;免疫抑制剤;低分子量G蛋白質
- Molecular mechanism of mDia function in T cell activationGrant-in-Aid for Young Scientists (B)Kyoto UniversityDean THUMKEOFrom 01 Apr. 2013, To 31 Mar. 2015, Project ClosedTCRシグナル;mDia;F-actin;T細胞;免疫抑制剤;アクチン
- Analysis of antitumor immunity induced by vaccinia virus with in vivo imagingGrant-in-Aid for Scientific Research (C)Kyoto UniversityYoshiki ArakawaFrom 01 Apr. 2013, To 31 Mar. 2016, Project Closed悪性脳腫瘍;ワクシニアウイルス;生体イメージング;腫瘍免疫;免疫誘導;ウイルス治療;悪性グリオーマ
- Elucidation of the role and mechanism of action of prostaglandin E2 in cancer though the immune suppression activity of Treg cellsGrant-in-Aid for Scientific Research (C)Basic Section 48030:Pharmacology-relatedKyoto UniversityThumkeo DeanFrom 01 Apr. 2023, To 31 Mar. 2026, Granted制御性T細胞;PGE2;腫瘍;Treg;免疫抑制;がん
list
Last Updated :2026/06/19
Education
Teaching subject(s)
- From 01 Apr. 2026, To 31 Mar. 2027ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Principles of Genetics-E2N492, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Introduction to Biochemistry-E2N490, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Principles of Genetics-E2N492, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Introduction to Biochemistry-E2N490, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Biochemistry-E2N490, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Principles of Genetics-E2N492, Spring, Institute for Liberal Arts and Sciences, 2
Participation in PhD Defense
- Targeting PAR-2 in Atopic Dermatitis: Preclinical Evaluation of the Novel Inhibitor E6795MIYANO NAOMI, Graduate School of Medicine, Sub-chief Examiner23 Mar. 2026
- A TBC1D9-Rab29 axis controls homeostatic NF-κB signaling and selective IL-6 production in epithelial cellsHU XIN, Graduate School of Medicine, Chief Examiner23 Mar. 2026
- Single-cell multiomic analysis revealed the differentiation, localization, and heterogeneity of IL10+ Foxp3- follicular T cells in humansFUJIOKA SHUSEI, Graduate School of Medicine, Sub-chief Examiner23 Jan. 2026
- Prostacyclin Assists in the Repair of Ruptured Amnions through the Proliferation and Migration of Amnion Mesenchymal CellsTAKAKURA MASAHITO, Graduate School of Medicine, Sub-chief Examiner23 Jan. 2026
- CD21lo B cell subsets are recruited to the central nervous system in acute neuromyelitis opticaNISHIGORI RYUSEI, Graduate School of Medicine, Sub-chief Examiner24 Sep. 2025
- Near-infrared photoimmunotherapy as a complementary modality to in situ vaccine in a preclinical pancreatic cancer modelYAKU HIROAKI, Graduate School of Medicine, Chief Examiner23 May 2025
- Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-cell Leukemia/LymphomaSHIMIZU TAKUYA, Graduate School of Medicine, Sub-chief Examiner25 Nov. 2025
- Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cellsDEGUCHI ERIKO, Graduate School of Medicine, Chief Examiner24 Mar. 2025
- A Deep Learning-Based Assay for Programmed Death Ligand 1 Immunohistochemistry Scoring in Non-Small Cell Lung Carcinoma: Does it Help Pathologists Score?ITO HIROAKI, Graduate School of Medicine, Sub-chief Examiner24 Sep. 2024
- Reduction of donor mononuclear phagocytes with clodronate-liposome during ex vivo lung perfusion attenuates ischemia-reperfusion injuryYAMANASHI KEIJI, Graduate School of Medicine, Sub-chief Examiner25 Nov. 2024
- High frequency of circulating non-classical monocytes is associated with stable remission in relapsing-remitting multiple sclerosisMINOTE MISAKO, Graduate School of Medicine, Sub-chief Examiner25 Nov. 2024
