FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms
Ashton L. Sigler; Scott B. Thompson; Logan Ellwood-Digel; Adithan Kandasamy; Mary J. Michaels; Dean Thumkeo; Shuh Narumiya; Juan C. Del Alamo; Jordan Jacobelli
Frontiers in Immunology, 2024年10月04日
Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.
Kimberly N Kremer; Alan Buser; Dean Thumkeo; Shuh Narumiya; Jordan Jacobelli; Roberta Pelanda; Raul M Torres
Proceedings of the National Academy of Sciences of the United States of America, 2022年04月12日
DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.
Adam J Kundishora; Samuel T Peters; Amélie Pinard; Daniel Duran; Shreyas Panchagnula; Tanyeri Barak; Danielle F Miyagishima; Weilai Dong; Hannah Smith; Jack Ocken; Ashley Dunbar; Carol Nelson-Williams; Shozeb Haider; Rebecca L Walker; Boyang Li; Hongyu Zhao; Dean Thumkeo; Arnaud Marlier; Phan Q Duy; Nicholas S Diab; Benjamin C Reeves; Stephanie M Robert; Nanthiya Sujijantarat; Amber N Stratman; Yi-Hsien Chen; Shujuan Zhao; Isabelle Roszko; Qiongshi Lu; Bo Zhang; Shrikant Mane; Christopher Castaldi; Francesc López-Giráldez; James R Knight; Michael J Bamshad; Deborah A Nickerson; Daniel H Geschwind; Shih-Shan Lang Chen; Phillip B Storm; Michael L Diluna; Charles C Matouk; Darren B Orbach; Seth L Alper; Edward R Smith; Richard P Lifton; Murat Gunel; Dianna M Milewicz; Sheng Chih Jin; Kristopher T Kahle
JAMA neurology, 2021年08月01日
Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction.
DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation.
Ronen Schneider; Konstantin Deutsch; Gregory J Hoeprich; Jonathan Marquez; Tobias Hermle; Daniela A Braun; Steve Seltzsam; Thomas M Kitzler; Youying Mao; Florian Buerger; Amar J Majmundar; Ana C Onuchic-Whitford; Caroline M Kolvenbach; Luca Schierbaum; Sophia Schneider; Abdul A Halawi; Makiko Nakayama; Nina Mann; Dervla M Connaughton; Verena Klämbt; Matias Wagner; Korbinian M Riedhammer; Lutz Renders; Yoshichika Katsura; Dean Thumkeo; Neveen A Soliman; Shrikant Mane; Richard P Lifton; Shirlee Shril; Mustafa K Khokha; Julia Hoefele; Bruce L Goode; Friedhelm Hildebrandt
American journal of human genetics, 2020年12月03日
mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
D Thumkeo; Y Katsura; Y Nishimura; P Kanchanawong; K Tohyama; T Ishizaki; S Kitajima; C Takahashi; T Hirata; N Watanabe; M F Krummel; S Narumiya
mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.
Sakamoto S; Thumkeo D; Ohta H; Zhang Z; Huang S; Kanchanawong P; Fuu T; Watanabe S; Shimada K; Fujihara Y; Yoshida S; Ikawa M; Watanabe N; Saitou M; Narumiya S
Targeting PAR-2 in Atopic Dermatitis: Preclinical Evaluation of the Novel Inhibitor E6795(アトピー性皮膚炎におけるPAR-2を標的とした新規阻害薬E6795の前臨床評価)
宮野 尚美, 医学研究科, 副査
2026年03月23日
A TBC1D9-Rab29 axis controls homeostatic NF-κB signaling and selective IL-6 production in epithelial cells(TBC1D9-Rab29 軸による上皮細胞における恒常的 NF-κB シグナル伝達と選択的 IL-6 産生の制御)
HU XIN, 医学研究科, 主査
2026年03月23日
Single-cell multiomic analysis revealed the differentiation, localization, and heterogeneity of IL10+ Foxp3- follicular T cells in humans(1細胞マルチオミクス解析により解明されたヒト IL10+ Foxp3- 濾胞T細胞の分化、局在、多様性)
藤岡 秀成, 医学研究科, 副査
2026年01月23日
Prostacyclin Assists in the Repair of Ruptured Amnions through the Proliferation and Migration of Amnion Mesenchymal Cells(プロスタサイクリンは羊膜間葉細胞の増殖と遊走を促すことで羊膜修復に寄与する)
髙倉 賢人, 医学研究科, 副査
2026年01月23日
CD21lo B cell subsets are recruited to the central nervous system in acute neuromyelitis optica(視神経脊髄炎の急性期にCD21lo B細胞サブセットが中枢神経系に動員される)
錦織 隆成, 医学研究科, 副査
2025年09月24日
Near-infrared photoimmunotherapy as a complementary modality to in situ vaccine in a preclinical pancreatic cancer model(前臨床膵癌モデルにおけるin situワクチン補完療法としての光免疫療法)
夜久 大晃, 医学研究科, 主査
2025年05月23日
Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-cell Leukemia/Lymphoma(YY1/EZH2およびMLH1のアップレギュレーションは成人T細胞白血病/リンパ腫の治療標的となる)
清水 拓也, 医学研究科, 副査
2025年11月25日
Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells(低親和性EGFRリガンドは細胞集団遊走における長距離シグナル伝達分子である)
出口 英梨子, 医学研究科, 主査
2025年03月24日
A Deep Learning-Based Assay for Programmed Death Ligand 1 Immunohistochemistry Scoring in Non-Small Cell Lung Carcinoma: Does it Help Pathologists Score?(非小細胞肺癌におけるPD-L1免疫染色判定のための深層学習アッセイ:深層学習アッセイは病理医の判定を助けるか)
伊藤 寛朗, 医学研究科, 副査
2024年09月24日
Reduction of donor mononuclear phagocytes with clodronate-liposome during ex vivo lung perfusion attenuates ischemia-reperfusion injury(体外肺灌流中のクロドロネートリポソーム投与による単核貪食細胞の除去は虚血再灌流障害を軽減する)
山梨 恵次, 医学研究科, 副査
2024年11月25日
High frequency of circulating non-classical monocytes is associated with stable remission in relapsing-remitting multiple sclerosis(末梢血における高頻度non-classical monocyteは再発寛解型多発性硬化症の長期寛解と関連する)