Basic Information

Faculty

• 医学部

Academic Degree

• 修士（生命科学）(京都大学)
• 博士（生命科学）(京都大学)

Research History

• Kyoto University

ID,URL

• J-Global ID

  201401099868538273

researchmap URL

• https://researchmap.jp/7000010464

Research

Research Topics, Overview of the research

• Research Topics

  Influences of the ROS to growth and division of spermatogonial stem cells.
  
  

• Overview of the research

  Reactive oxygen species (ROS) generation is implicated in stem cell self-renewal in several tissues but is thought to be detrimental for spermatogenesis as well as SSCs. We show that ROS are generated via the AKT and MEK signaling pathways. SSCs depleted of ROS stopped proliferating, but they showed enhanced self-renewal when ROS levels were increased by the addition of hydrogen peroxide, which induced the phosphorylation of stress kinases p38 MAPK and JNK. Moreover, ROS depletion in vivo decreased SSC number in the testis, and Nox1-deficient SSCs exhibited reduced self-renewal division upon serial transplantation. ROS generated by Nox1 play critical roles in SSC self-renewal via the activation of the p38 MAPK and JNK pathways.

External funds: Kakenhi

• Elucidation of oxygen metabolism regulation in Spermatogonial Stem cells.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42030:Animal life science-related

  Kyoto University

  Hiroko Morimoto

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  活性酸素;精子幹細胞;酸素応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K06445/
• Elucidation of the transcriptional regulation of ROS in Spermatogonial Stem cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hiroko Morimoto

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  精子幹細胞;活性酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08136/
• Genetic engineering of primordial germ cells for germline modification

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Takashi Shinohara

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  始原生殖細胞;精子形成;卵子形成;Kit

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14362/
• The elucidation of mechanisms of the cell death in SSCs induced by radiation

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  hiroko Morimoto

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  精子幹細胞;活性酸素;放射線;細胞死;p53

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26340021/
• Elucidation of cupper metabolism regulation in spermatogonial stem cells.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44020:Developmental biology-related

  Kyoto University

  森本 裕子

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  精子幹細胞;銅代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05781/