Sekiyama, Naotaka(Graduate School of Science, Division of Biological Sciences) | Activity Database on Education and Research, Kyoto University

Sekiyama, Naotaka

Graduate School of Science, Division of Biological Sciences Assistant Professor

Last Updated :2025/05/27

Basic Information

Faculty

理学部

Academic Degree

修士（工学）(京都大学)

博士（工学）(京都大学)

ID,URL

J-Global ID
201501064299030885

researchmap URL

https://researchmap.jp/7000011361

Last Updated :2025/05/27

Research

Research Areas

Life sciences, Structural biochemistry

Papers

Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy.
Kayo Imamura; Ken-Ichi Akagi; Yohei Miyanoiri; Hirokazu Tsujimoto; Takatsugu Hirokawa; Hideo Ashida; Kaori Murakami; Asuka Inoue; Ryoji Suno; Takahisa Ikegami; Naotaka Sekiyama; So Iwata; Takuya Kobayashi; Hidehito Tochio
Structure (London, England : 1993), 07 Mar. 2024

Toward a high-resolution mechanism of intrinsically disordered protein self-assembly.
Naotaka Sekiyama; Ryoga Kobayashi; Takashi S Kodama
Journal of biochemistry, 31 Oct. 2023

ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.
Naotaka Sekiyama; Kiyofumi Takaba; Saori Maki-Yonekura; Ken-Ichi Akagi; Yasuko Ohtani; Kayo Imamura; Tsuyoshi Terakawa; Keitaro Yamashita; Daigo Inaoka; Koji Yonekura; Takashi S Kodama; Hidehito Tochio
Proceedings of the National Academy of Sciences of the United States of America, 20 Sep. 2022
Access this paper :

Conformational Space Sampled by Domain Reorientation of Linear Diubiquitin Reflected in Its Binding Mode for Target Proteins.
Xue-Ni Hou; Naotaka Sekiyama; Yasuko Ohtani; Feng Yang; Yohei Miyanoiri; Ken-Ichi Akagi; Xun-Cheng Su; Hidehito Tochio
Chemphyschem : a European journal of chemical physics and physical chemistry, 16 Jul. 2021

1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E.
Naotaka Sekiyama; Andras Boeszoermenyi; Haribabu Arthanari; Gerhard Wagner; Mélissa Léger-Abraham
Biomolecular NMR assignments, Oct. 2017

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Naotaka Sekiyama; Haribabu Arthanari; Evangelos Papadopoulos; Ricard A Rodriguez-Mias; Gerhard Wagner; Mélissa Léger-Abraham
Proceedings of the National Academy of Sciences of the United States of America, 28 Jul. 2015

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
Kyohei Arita; Shin Isogai; Takashi Oda; Motoko Unoki; Kazuya Sugita; Naotaka Sekiyama; Keiko Kuwata; Ryuji Hamamoto; Hidehito Tochio; Mamoru Sato; Mariko Ariyoshi; Masahiro Shirakawa
Proceedings of the National Academy of Sciences of the United States of America, 07 Aug. 2012

NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80.
Naotaka Sekiyama; Jungoo Jee; Shin Isogai; Ken-Ichi Akagi; Tai-Huang Huang; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa
Journal of biomolecular NMR, Apr. 2012

Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.
Naotaka Sekiyama; Kyohei Arita; Yoshihiro Ikeda; Kohtaro Hashiguchi; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa
Proteins, 01 May 2010

Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.
Naotaka Sekiyama; Takahisa Ikegami; Tsutomu Yamane; Mitsunori Ikeguchi; Yasuhiro Uchimura; Daichi Baba; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa
The Journal of biological chemistry, 19 Dec. 2008

Misc.

TOPICS 生化学･分子生物学 TIA-1プリオン様ドメインのALS変異は高度に凝縮した病原体構造を誘起する
関山直孝
医学のあゆみ, 24 Jun. 2023

剪断力により誘起される相分離の機構解明—Elucidation of the Mechanism of Phase Separation Induced by Shear Force
菅瀬謙治; 関山直孝; 吉田紀生
豊田研究報告 = Reports of Toyota Physical and Chemical Research Institute, May 2020

Translation Control Regulated by the Change of eIF4E Interaction
SEKIYAMA Naotaka
Seibutsu Butsuri, 2016

3P017 Contribution of dehydration to reduced cytochrome c folding revealed by high pressure measurements
Kimura T.; Sekiyama N.; Sakamoto K.; Morishima I.; Ishimori K.
Seibutsu Butsuri, 2004

External funds: Kakenhi

Structural analysis of the reversible self-assembly mechanism by intrinsically disordered proteins
Grant-in-Aid for Scientific Research (C)
Basic Section 43040:Biophysics-related
Kyoto University
Naotaka Sekiyama
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
液-液相分離;天然変性タンパク質;神経変性疾患;タンパク質;相分離;構造生物学;RNA;天然変性領域
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06584/

Self-assembly mechanism of intrinsically disordered proteins in stress granules
Grant-in-Aid for Young Scientists (B)
Kyoto University
Naotaka Sekiyama
From 01 Apr. 2017, To 31 Mar. 2019, Project Closed
タンパク質;RNA;構造生物学;液液相分離;蛋白質;凝集体;発現制御;ストレス顆粒;天然変性蛋白質
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15104/

Regulation mechanisms of TOP mRNA translation in proliferation
Grant-in-Aid for Research Activity Start-up
Kyoto University
Naotaka Sekiyama
From 28 Aug. 2015, To 31 Mar. 2017, Project Closed
翻訳;蛋白質;リン酸化;分子動力学シミュレーション;生物物理;RNA;翻訳制御;RNA結合蛋白質
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06325/

生化学的手法を用いた天然変性タンパク質の自己凝縮過程を制御する動的溶液環境の解明
Grant-in-Aid for Transformative Research Areas (B)
Transformative Research Areas, Section (III)
Kyoto University
関山直孝
From 20 May 2022, To 31 Mar. 2025, Granted
液液相分離;非膜型オルガネラ;天然変性タンパク質;アミロイド線維;液-液相分離;アミロイド線維化
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22H05090/

動的溶液科学の推進
Grant-in-Aid for Transformative Research Areas (B)
Transformative Research Areas, Section (III)
Kyoto University
関山直孝
From 20 May 2022, To 31 Mar. 2025, Granted
液液相分離;非膜型オルガネラ;天然変性タンパク質;アミロイド線維;動的溶液環境;液-液相分離;アミロイド線維化
https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22H05087/

Multi-scale understanding of Self-condensation mechanism driven by Dynamic solution environments
Grant-in-Aid for Transformative Research Areas (B)
From 20 May 2022, To 31 Mar. 2025
https://kaken.nii.ac.jp/grant/KAKENHI-AREA-22B308/

Multi-scale understanding of Self-condensation mechanism driven by Dynamic solution environments
Grant-in-Aid for Transformative Research Areas (B)
From 20 May 2022, To 31 Mar. 2025
https://kaken.nii.ac.jp/grant/KAKENHI-AREA-22B308/

Last Updated :2025/05/27

Education

Teaching subject(s)

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IA
9013, Spring, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IB
9014, Fall, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IIA
9017, Spring, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology ID
9016, Fall, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IC
9015, Spring, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IID
9020, Fall, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IIC
9019, Spring, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Seminar on Structural Physiology IIB
9018, Fall, Graduate School of Science, 1

From 01 Apr. 2024, To 31 Mar. 2025
Special Study CourseII(Biological Sciences) 15
8718, Year-long, Faculty of Science, 12

From 01 Apr. 2024, To 31 Mar. 2025
Seminars in Biological Science A
4730, Fall, Faculty of Science, 2

From 01 Apr. 2024, To 31 Mar. 2025
Molecular Functions in Biological Systems
3767, Spring, Faculty of Science, 2

From 01 Apr. 2024, To 31 Mar. 2025
Laboratory work in Biological Science E
3766, Fall, Faculty of Science, 2

From 01 Apr. 2024, To 31 Mar. 2025
Fundamental Experiments of Cellular and Molecular Biology
2729, Fall, Faculty of Science, 4

From 01 Apr. 2024, To 31 Mar. 2025
Molecular Functions in Biological Systems
9127, Spring, Graduate School of Science, 2

From 01 Apr. 2024, To 31 Mar. 2025
Advanced Course on Biological Science B
9012, Fall, Graduate School of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IB
9014, Fall, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IA
9013, Spring, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IIA
9017, Spring, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology ID
9016, Fall, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IC
9015, Spring, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IIB
9018, Fall, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IID
9020, Fall, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Seminar on Structural Physiology IIC
9019, Spring, Graduate School of Science, 1

From 01 Apr. 2023, To 31 Mar. 2024
Special Study CourseII(Biological Sciences) 15
8718, Year-long, Faculty of Science, 12

From 01 Apr. 2023, To 31 Mar. 2024
Seminars in Biological Science A
4730, Fall, Faculty of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Molecular Functions in Biological Systems
3767, Spring, Faculty of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Laboratory work in Biological Science E
3766, Fall, Faculty of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Course on Biological Science B
9012, Fall, Graduate School of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Molecular Functions in Biological Systems
9127, Spring, Graduate School of Science, 2

From 01 Apr. 2023, To 31 Mar. 2024
Fundamental Experiments of Cellular and Molecular Biology
2729, Fall, Faculty of Science, 4

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IIC
9019, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IIA
9017, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminars in Biological Science A
4730, Fall, Faculty of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IB
9014, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Molecular Functions in Biological Systems
9127, Spring, Graduate School of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Course on Biological Science B
9012, Fall, Graduate School of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Laboratory work in Biological Science E
3766, Fall, Faculty of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Fundamental Experiments of Cellular and Molecular Biology
2729, Fall, Faculty of Science, 4

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IC
9015, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology ID
9016, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IIB
9018, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Special Study CourseII(Biological Sciences) 15
8718, Year-long, Faculty of Science, 12

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IA
9013, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Molecular Functions in Biological Systems
3767, Spring, Faculty of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Structural Physiology IID
9020, Fall, Graduate School of Science, 1

From Apr. 2015, To Mar. 2016
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminars in Biological Science A
Fall, 理学部

From Apr. 2016, To Mar. 2017
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminars in Biological Science A
Fall, 理学部

From Apr. 2017, To Mar. 2018
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2018, To Mar. 2019
Experimental Course of Fundamental Biology III
Fall, 理学部

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminars in Biological Science A
Fall, 理学部

From Apr. 2018, To Mar. 2019
Laboratory work in Biological Science B
Spring, 理学部

From Apr. 2018, To Mar. 2019
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2019, To Mar. 2020
Experimental Course of Fundamental Biology III
Fall, 理学部

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminars in Biological Science A
Fall, 理学部

From Apr. 2019, To Mar. 2020
Laboratory work in Biological Science B
Spring, 理学部

From Apr. 2019, To Mar. 2020
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminars in Biological Science A
Fall, 理学部

From Apr. 2020, To Mar. 2021
Laboratory Work in Biological Science B
Spring, 理学部

From Apr. 2020, To Mar. 2021
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

From Apr. 2020, To Mar. 2021
Fundamental Experiments of Cellular and Molecular Biology
Fall, 理学部

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IA
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IB
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IC
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology ID
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IIA
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IIB
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IIC
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Structural Physiology IID
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Molecular Functions in Biological Systems
Spring, 理学部

From Apr. 2021, To Mar. 2022
Molecular Functions in Biological Systems
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminars in Biological Science A
Fall, 理学部

From Apr. 2021, To Mar. 2022
Laboratory Work in Biological Science B
Spring, 理学部

From Apr. 2021, To Mar. 2022
Advanced Course on Biological Science B
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Special Study CourseII(Biological Sciences) 15
Year-long, 理学部

Last Updated :2025/05/27

Administration

Faculty management (title, position)

From 01 Apr. 2024, To 31 Mar. 2025
理学研究科広報小委員会委員

From 01 Apr. 2022, To 31 Mar. 2023
理学研究科技術部研究機器開発支援室運営委員会委員

From 01 Apr. 2015, To 31 Mar. 2016
理学研究科植物園運営委員会委員

From 01 Apr. 2016, To 31 Mar. 2017
理学研究科植物園運営委員会委員

From 01 Apr. 2017, To 31 Mar. 2018
理学研究科広報委員会　広報小委員会委員

From 01 Apr. 2017, To 31 Mar. 2018
理学研究科植物園運営委員会委員

From 01 Apr. 2018, To 31 Mar. 2019
理学研究科植物園運営委員会委員

From 01 Apr. 2019, To 31 Mar. 2020
理学研究科技術部研究機器開発支援室運営委員会委員

From 01 Apr. 2019, To 31 Mar. 2021
理学研究科植物園運営委員会委員

From 01 Apr. 2020, To 31 Mar. 2021
理学研究科技術部研究機器開発支援室運営委員会委員

From 01 Apr. 2021, To 31 Mar. 2022
理学研究科技術部研究機器開発支援室運営委員会委員

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