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岡本 郁弘

オカモト イクヒロ

高等研究院 ヒト生物学高等研究拠点 特定講師

岡本 郁弘
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    Last Updated :2022/05/14

    基本情報

    学位

    • 修士(地球環境科学)(北海道大学)
    • 博士(地球環境科学)(北海道大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      研究

      研究テーマ・研究概要

      • 研究テーマ

        哺乳類におけるX染色体の遺伝子量補正

      研究分野

      • ライフサイエンス, 分子生物学

      論文

      • The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
        Kotaro Sasaki; Akiko Oguchi; Keren Cheng; Yasuhiro Murakawa; Ikuhiro Okamoto; Hiroshi Ohta; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Takuya Yamamoto; Yasunari Seita; Mitinori Saitou
        Cell reports, 2021年05月04日, 査読有り
      • GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program.
        Yoji Kojima; Chika Yamashiro; Yusuke Murase; Yukihiro Yabuta; Ikuhiro Okamoto; Chizuru Iwatani; Hideaki Tsuchiya; Masataka Nakaya; Tomoyuki Tsukiyama; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou
        Life science alliance, 2021年05月, 査読有り
      • Capturing Human Trophoblast Development with Naive Pluripotent Stem Cells In Vitro
        Shingo Io; Mio Kabata; Yoshiki Iemura; Katsunori Semi; Nobuhiro Morone; Ikuhiro Okamoto; Tomonori Nakamura; Yoji Kojima; Chizuru Iwatani; Hideaki Tsuchiya; Belinda Kaswandy; Eiji Kondoh; Mitinori Saitou; Takuya Yamamoto; Masaki Mandai; Yasuhiro Takashima
        2020年12月18日, 査読有り
      • Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys.
        Sakai Y; Nakamura T; Okamoto I; Gyobu-Motani S; Ohta H; Yabuta Y; Tsukiyama T; Iwatani C; Tsuchiya H; Ema M; Morizane A; Takahashi J; Yamamoto T; Saitou M
        Biology of reproduction, 2019年11月, 査読有り
      • A symmetric toggle switch explains the onset of random X inactivation in different mammals.
        Mutzel V; Okamoto I; Dunkel I; Saitou M; Giorgetti L; Heard E; Schulz EG
        Nature structural & molecular biology, 2019年05月, 査読有り
      • Generation of human oogonia from induced pluripotent stem cells in vitro.
        Yamashiro C; Sasaki K; Yabuta Y; Kojima Y; Nakamura T; Okamoto I; Yokobayashi S; Murase Y; Ishikura Y; Shirane K; Sasaki H; Yamamoto T; Saitou M
        Science (New York, N.Y.), 2018年10月, 査読有り
      • Combined Immunofluorescence, RNA FISH, and DNA FISH in Preimplantation Mouse Embryos.
        Okamoto I
        Methods in molecular biology (Clifton, N.J.), 2018年, 査読有り, 筆頭著者, 最終著者, 責任著者
      • Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass
        Maud Borensztein; Ikuhiro Okamoto; Laurene Syx; Guillaume Guilbaud; Christel Picard; Katia Ancelin; Rafael Galupa; Patricia Diabangouaya; Nicolas Servant; Emmanuel Barillot; Azim Surani; Mitinori Saitou; Chong-Jian Chen; Konstantinos Anastassiadis; Edith Heard
        NATURE COMMUNICATIONS, 2017年11月, 査読有り
      • Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys
        Tomonori Nakamura; Yukihiro Yabuta; Ikuhiro Okamoto; Kotaro Sasaki; Chizuru Iwatani; Hideaki Tsuchiya; Mitinori Saitou
        Scientific Data, 2017年06月, 査読有り
      • In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.
        Ohta H; Kurimoto K; Okamoto I; Nakamura T; Yabuta Y; Miyauchi H; Yamamoto T; Okuno Y; Hagiwara M; Shirane K; Sasaki H; Saitou M
        The EMBO journal, 2017年05月, 査読有り
      • RNA FISH to study zygotic genome activation in early mouse embryos
        Noémie Ranisavljevic; Ikuhiro Okamoto; Edith Heard; Katia Ancelin
        Methods in Molecular Biology, 2017年, 査読有り
      • In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.
        Ishikura Y; Yabuta Y; Ohta H; Hayashi K; Nakamura T; Okamoto I; Yamamoto T; Kurimoto K; Shirane K; Sasaki H; Saitou M
        Cell reports, 2016年12月, 査読有り
      • The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.
        Sasaki K; Nakamura T; Okamoto I; Yabuta Y; Iwatani C; Tsuchiya H; Seita Y; Nakamura S; Shiraki N; Takakuwa T; Yamamoto T; Saitou M
        Developmental cell, 2016年10月, 査読有り
      • A developmental coordinate of pluripotency among mice, monkeys and humans.
        Nakamura T; Okamoto I; Sasaki K; Yabuta Y; Iwatani C; Tsuchiya H; Seita Y; Nakamura S; Yamamoto T; Saitou M
        Nature, 2016年08月, 査読有り
      • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
        Sasaki K; Yokobayashi S; Nakamura T; Okamoto I; Yabuta Y; Kurimoto K; Ohta H; Moritoki Y; Iwatani C; Tsuchiya H; Nakamura S; Sekiguchi K; Sakuma T; Yamamoto T; Mori T; Woltjen K; Nakagawa M; Yamamoto T; Takahashi K; Yamanaka S
        Cell stem cell, 2015年08月, 査読有り
      • SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.
        Nakamura T; Yabuta Y; Okamoto I; Aramaki S; Yokobayashi S; Kurimoto K; Sekiguchi K; Nakagawa M; Yamamoto T; Saitou M
        Nucleic acids research, 2015年05月, 査読有り
      • The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals
        Rachel Duffie; Sophie Ajjan; Maxim V. Greenberg; Natasha Zamudio; Martin Escamilla del Arenal; Julian Iranzo; Ikuhiro Okamoto; Sandrine Barbaux; Patricia Fauque; Deborah Bourc'his
        GENES & DEVELOPMENT, 2014年03月, 査読有り
      • The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.
        Schulz EG; Meisig J; Nakamura T; Okamoto I; Sieber A; Picard C; Borensztein M; Saitou M; Blüthgen N; Heard E
        Cell Stem Cell, 2014年02月, 査読有り
      • RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells (Retracted article. See vol. 9, e1005519, 2015)
        Constance Ciaudo; Florence Jay; Ikuhiro Okamoto; Chong-Jian Chen; Alexis Sarazin; Nicolas Servant; Emmanuel Barillot; Edith Heard; Olivier Voinnet
        PLOS GENETICS, 2013年11月, 査読有り
      • Initiation of X chromosome inactivation during early embryogenesis in mice and in humans
        Catherine Patrat; Ikuhiro Okamoto; Edith Heard
        BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2013年03月, 査読有り
      • Spatial partitioning of the regulatory landscape of the X-inactivation centre
        Elphege P. Nora; Bryan R. Lajoie; Edda G. Schulz; Luca Giorgetti; Ikuhiro Okamoto; Nicolas Servant; Tristan Piolot; Nynke L. van Berkum; Johannes Meisig; John Sedat; Joost Gribnau; Emmanuel Barillot; Nils Bluethgen; Job Dekker; Edith Heard
        NATURE, 2012年05月, 査読有り
      • Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development (vol 472, pg 370, 2011)
        Ikuhiro Okamoto; Catherine Patrat; Dominique Thepot; Nathalie Peynot; Patricia Fauque; Nathalie Daniel; Patricia Diabangouaya; Jean-Philippe Wolf; Jean-Paul Renard; Veronique Duranthon; Edith Heard
        NATURE, 2011年06月, 査読有り
      • Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development
        Ikuhiro Okamoto; Catherine Patrat; Dominique Thepot; Nathalie Peynot; Patricia Fauque; Nathalie Daniel; Patricia Diabangouaya; Jean-Philippe Wolf; Jean-Paul Renard; Veronique Duranthon; Edith Heard
        NATURE, 2011年04月, 査読有り
      • A Strand-Specific Burst in Transcription of Pericentric Satellites Is Required for Chromocenter Formation and Early Mouse Development
        Aline V. Probst; Ikuhiro Okamoto; Miguel Casanova; Fatima El Marjou; Patricia Le Baccon; Genevieve Almouzni
        DEVELOPMENTAL CELL, 2010年10月, 査読有り
      • Lessons from comparative analysis of X-chromosome inactivation in mammals
        Ikuhiro Okamoto; Edith Heard
        CHROMOSOME RESEARCH, 2009年07月, 査読有り
      • Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development
        Hisanobu Oda; Ikuhiro Okamoto; Niall Murphy; Jianhua Chu; Sandy M. Price; Michael M. Shen; Maria Elena Torres-Padilla; Edith Heard; Danny Reinberg
        MOLECULAR AND CELLULAR BIOLOGY, 2009年04月, 査読有り
      • The dynamics of imprinted X inactivation during preimplantation development in mice
        I. Okamoto; E. Heard
        CYTOGENETIC AND GENOME RESEARCH, 2006年, 査読有り
      • Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
        Okamoto, I; D Arnaud; P Le Baccon; AP Otte; CM Disteche; P Avner; E Heard
        NATURE, 2005年11月, 査読有り
      • Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte
        SQ Bao; N Miyoshi; Okamoto, I; T Jenuwein; E Heard; MA Surani
        EMBO REPORTS, 2005年08月, 査読有り
      • Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
        T Kunath; D Arnaud; GD Uy; L Okamoto; C Chureau; Y Yamanaka; E Heard; RL Gardner; P Avner; J Rossant
        DEVELOPMENT, 2005年04月, 査読有り
      • Mammalian X-chromosome inactivation: An epigenetics paradigm
        E Heard; J Chaumeil; O Masui; Okamoto, I
        COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2004年, 査読有り
      • X-chromosome inactivation in mouse embryonic stem cells: Analysis of histone modifications and transcriptional activity using immunofluorescence and FISH
        J Chaumeil; Okamoto, I; E Heard
        CHROMATIN AND CHROMATIN REMODELING ENZYMES, PT B, 2004年, 査読有り
      • Epigenetic dynamics of imprinted X inactivation during early mouse development
        Okamoto, I; AP Otte; CD Allis; D Reinberg; E Heard
        SCIENCE, 2004年01月, 査読有り
      • Developmental abnormalities in mouse embryos tetrasomic for chromosome 11: Apparent similarity to embryos functionally disomic for the X chromosome
        H Mizuno; Okamoto, I; N Takagi
        GENES & GENETIC SYSTEMS, 2002年08月, 査読有り
      • Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells
        J Chaumeil; Okamoto, I; M Guggiari; E Heard
        CYTOGENETIC AND GENOME RESEARCH, 2002年, 査読有り
      • X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation
        Okamoto, I; SS Tan; N Takagi
        DEVELOPMENT, 2000年10月, 査読有り
      • The X chromosome dosage compensation program during the development of cynomolgus monkeys.
        Ikuhiro Okamoto; Tomonori Nakamura; Kotaro Sasaki; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Shin-Ichiro Nakamura; Masatsugu Ema; Takuya Yamamoto; Mitinori Saitou
        Science (New York, N.Y.), 2021年11月19日, 査読有り, 筆頭著者, 責任著者

      MISC

      • Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.
        Shoma Matsumoto; Christopher J Porter; Naomi Ogasawara; Chizuru Iwatani; Hideaki Tsuchiya; Yasunari Seita; Yu-Wei Chang; Ikuhiro Okamoto; Mitinori Saitou; Masatsugu Ema; Theodore J Perkins; William L Stanford; Satoshi Tanaka
        Scientific reports, 2020年04月22日

      外部資金:科学研究費補助金

      • 臓器形成期までの生体内情報取得と生理的Ex vivo culture法の確立
        学術変革領域研究(B)
        学術変革領域研究区分(Ⅲ)
        京都大学
        中村 友紀
        自 2020年10月02日, 至 2023年03月31日, 交付
        霊長類;着床後胚発生;発生学
      • 霊長類におけるX染色体不活性化機構の解明
        基盤研究(C)
        小区分42040:実験動物学関連
        京都大学
        岡本 郁弘
        自 2018年04月01日, 至 2021年03月31日, 完了
        カニクイザル;X染色体の不活性化;ゲノム編集;ノックアウト細胞;X染色体不活性化;XIST RNA;X染色体の再活性化;初期胚;始原生殖細胞
      • 始原生殖細胞における不活性X染色体再活性化メカニズムの解明
        基盤研究(B)
        京都大学
        岡本 郁弘
        自 2013年04月01日, 至 2017年03月31日, 完了
        マウス;X染色体;再活性化;始原生殖細胞;始源生殖細胞;不活性X染色体の再活性化;不活性X染色体;リプログラミング;ゲノムリプログラミング
      • 霊長類のX染色体不活性化維持機構の解明
        基盤研究(B)
        小区分42040:実験動物学関連
        京都大学
        岡本 郁弘
        自 2022年04月01日, 至 2027年03月31日, 採択
      list
        Last Updated :2022/05/14

        教育

        非常勤講師

        • 自 2013年06月21日, 至 2013年06月21日
          分子生物学特論
          前期, 北海道大学, 大学院生命科学院
        • 自 2018年10月01日, 至 2018年10月01日
          大学院特別セミナー 医学特論
          後期, 富山大学, 医学薬学教育部

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