基本情報

学位

• 修士（生物工学）(富山県立大学)
• 博士（生物資源学）(福井県立大学)

ID,URL

• J-Global ID

  201901002451459900

researchmap URL

• https://researchmap.jp/yabyab

研究

研究テーマ・研究概要

• 研究テーマ

  ヒト、カニクイザル、マウスの生殖細胞の発生におけるエピゲノムの解析

• 研究概要

  哺乳類の生殖細胞は、胎児期の発生過程において次世代への全能性の再獲得のためにエピゲノムのリプログラミングを行ってゲノムを初期化しながら精子や卵に分化する。この時期の生殖細胞分化課程における、ゲノム全体のエピゲノムの初期化のメカニズムを詳細に解析する。
  生体では困難な解析だが、当研究室で誘導したマウスES細胞、カニクイザルES細胞、ヒトiPS細胞を用いた擬似的な生殖細胞要細胞(PGCLC)を用いて、DNAメチル化、ヒストン修飾などの変化からメカニズムを解明する。

研究分野

• ライフサイエンス, 発生生物学

論文

• In vitro reconstitution of epigenetic reprogramming in the human germ line

  Yusuke Murase; Ryuta Yokogawa; Yukihiro Yabuta; Masahiro Nagano; Yoshitaka Katou; Manami Mizuyama; Ayaka Kitamura; Pimpitcha Puangsricharoen; Chika Yamashiro; Bo Hu; Ken Mizuta; Kosuke Ogata; Yasushi Ishihama; Mitinori Saitou

  Nature, 2024年05月20日

  
• DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells

  Keisuke Toriyama; Wan Kin Au Yeung; Azusa Inoue; Kazuki Kurimoto; Yukihiro Yabuta; Mitinori Saitou; Toshinobu Nakamura; Toru Nakano; Hiroyuki Sasaki

  BMC Genomics, 2024年04月05日

  
• 【DNAチップ/マイクロアレイ臨床応用の実際 基礎、最新技術、臨床・創薬研究応用への実際から今後の展開・問題点まで】DNAチップ/マイクロアレイの基礎 発現解析 単一細胞マイクロアレイ法の開発と応用

  斎藤 通紀; 藪田 幸宏; 栗本 一基

  遺伝子医学MOOK, 2008年06月

  
• Close Up実験法 単一細胞マイクロアレイ解析を可能とするPCRを用いたcDNA増幅法

  栗本 一基; 薮田 幸宏; 大日向 康秀; 斎藤 通紀

  実験医学, 2006年09月

  
• Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.

  Serena F Generoso; Maria Victoria Neguembor; Elliot A Hershberg; Ruslan I Sadreyev; Kazuki Kurimoto; Yukihiro Yabuta; Raffaele Ricci; Pauline Audergon; Moritz Bauer; Mitinori Saitou; Konrad Hochedlinger; Brian J Beliveau; Maria Pia Cosma; Jeannie T Lee; Bernhard Payer

  Proceedings of the National Academy of Sciences of the United States of America, 2023年01月24日

  
• ヒト多能性幹細胞を用いた始原生殖細胞様細胞の試験管内誘導

  横林 しほり; 佐々木 恒太郎; 中村 友紀; 岡本 郁弘; 薮田 幸宏; 栗本 一基; 大田 浩; 守時 良演; 佐々木 裕子; 中川 誠人; 斎藤 通紀

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月

  
• 体外誘導系マウス始原生殖細胞分化過程のDNAメチル化動態と遺伝子発現制御

  白根 健次郎; 栗本 一基; 薮田 幸宏; 林 克彦; 大田 浩; 中村 友紀; 渡辺 亮; 斎藤 通紀; 佐々木 裕之

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月

  
• マウス始原生殖細胞発生過程におけるBLIMP1の系統的機能解析 調節標的遺伝子の変化と細胞特性維持への寄与

  山城 知佳; 廣田 孝幸; 栗本 一基; 中村 友紀; 薮田 幸宏; 長岡 創; 大田 浩; 山本 拓也; 斎藤 通紀

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月

  
• シグナル伝達因子により制御されるマウス生殖細胞系列の決定機構の解明

  荒牧 伸弥; 林 克彦; 栗本 一基; 薮田 幸宏; 大田 浩; 斎藤 通紀

  The Journal of Reproduction and Development, 2014年08月

  
• Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

  Sayuri Gyobu‐Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamoto; Tomonori Nakamura; Mitinori Saitou

  The EMBO Journal, 2023年03月16日, 査読有り

  
• 始原生殖細胞形成過程におけるエピゲノムリモデリングの動態

  栗本 一基; 薮田 幸宏; 大田 浩; 白根 健次郎; 林 克彦; 三谷 忠宏; 木村 宏; 山本 拓也; 白髭 克彦; 佐々木 裕之; 斎藤 通紀

  生命科学系学会合同年次大会, 2017年12月

  
• Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys

  Ken Mizuta; Yoshitaka Katou; Baku Nakakita; Aoi Kishine; Yoshiaki Nosaka; Saki Saito; Chizuru Iwatani; Hideaki Tsuchiya; Ikuo Kawamoto; Masataka Nakaya; Tomoyuki Tsukiyama; Masahiro Nagano; Yoji Kojima; Tomonori Nakamura; Yukihiro Yabuta; Akihito Horie; Masaki Mandai; Hiroshi Ohta; Mitinori Saitou

  The EMBO Journal, 2022年08月

  この論文にアクセスする：

  
• Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development (Genome Research (2011) 21 (2058-2066))

  Kenji Ichiyanagi; Yufeng Li; Toshiaki Watanabe; Tomoko Ichiyanagi; Kei Fukuda; Junko Kitayama; Yasuhiro Yamamoto; Satomi Kuramochi-Miyagawa; Toru Nakano; Yukihiro Yabuta; Yoshiyuki Seki; Mitinori Saitou; Hiroyuki Sasaki

  Genome Research, 2012年04月01日

  
• The X chromosome dosage compensation program during the development of cynomolgus monkeys.

  Ikuhiro Okamoto; Tomonori Nakamura; Kotaro Sasaki; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Shin-Ichiro Nakamura; Masatsugu Ema; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 2021年11月19日

  
• Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

  Shihori Yokobayashi; Yukihiro Yabuta; Masato Nakagawa; Keisuke Okita; Bo Hu; Yusuke Murase; Tomonori Nakamura; Guillaume Bourque; Jacek Majewski; Takuya Yamamoto; Mitinori Saitou

  Cell Reports, 2021年11月

  この論文にアクセスする：

  
• In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells.

  Yukiko Ishikura; Hiroshi Ohta; Takuya Sato; Yusuke Murase; Yukihiro Yabuta; Yoji Kojima; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Takehiko Ogawa; Mitinori Saitou

  Cell stem cell, 2021年09月01日

  
• The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.

  Kei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki Fujita

  Current biology : CB, 2021年05月28日

  
• The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.

  Kotaro Sasaki; Akiko Oguchi; Keren Cheng; Yasuhiro Murakawa; Ikuhiro Okamoto; Hiroshi Ohta; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Takuya Yamamoto; Yasunari Seita; Mitinori Saitou

  Cell reports, 2021年05月04日

  この論文にアクセスする：

  
• GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program.

  Yoji Kojima; Chika Yamashiro; Yusuke Murase; Yukihiro Yabuta; Ikuhiro Okamoto; Chizuru Iwatani; Hideaki Tsuchiya; Masataka Nakaya; Tomoyuki Tsukiyama; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  Life science alliance, 2021年05月

  この論文にアクセスする：

  
• Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†.

  Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Tomonori Nakamura; Yusuke Murase; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, 2021年02月11日

  
• Long-term expansion with germline potential of human primordial germ cell-like cells in vitro.

  Yusuke Murase; Yukihiro Yabuta; Hiroshi Ohta; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  The EMBO journal, 2020年11月02日

  
• Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys†.

  Yoshitake Sakai; Tomonori Nakamura; Ikuhiro Okamoto; Sayuri Gyobu-Motani; Hiroshi Ohta; Yukihiro Yabuta; Tomoyuki Tsukiyama; Chiduru Iwatani; Hideaki Tsuchiya; Masatsugu Ema; Asuka Morizane; Jun Takahashi; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, 2020年03月13日

  
• ZGLP1 is a determinant for the oogenic fate in mice.

  So I Nagaoka; Fumio Nakaki; Hidetaka Miyauchi; Yoshiaki Nosaka; Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Katsuhiko Hayashi; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 2020年03月06日

  この論文にアクセスする：

  
• Generation of human oogonia from induced pluripotent stem cells in vitro.

  Chika Yamashiro; Kotaro Sasaki; Yukihiro Yabuta; Yoji Kojima; Tomonori Nakamura; Ikuhiro Okamoto; Shihori Yokobayashi; Yusuke Murase; Yukiko Ishikura; Kenjiro Shirane; Hiroyuki Sasaki; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 2018年10月19日

  
• Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1.

  Tadahiro Mitani; Yukihiro Yabuta; Hiroshi Ohta; Tomonori Nakamura; Chika Yamashiro; Takuya Yamamoto; Mitinori Saitou; Kazuki Kurimoto

  Nucleic acids research, 2017年12月01日

  
• Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice.

  Hidetaka Miyauchi; Hiroshi Ohta; So Nagaoka; Fumio Nakaki; Kotaro Sasaki; Katsuhiko Hayashi; Yukihiro Yabuta; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  The EMBO journal, 2017年11月02日

  
• Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells.

  Yoji Kojima; Kotaro Sasaki; Shihori Yokobayashi; Yoshitake Sakai; Tomonori Nakamura; Yukihiro Yabuta; Fumio Nakaki; So Nagaoka; Knut Woltjen; Akitsu Hotta; Takuya Yamamoto; Mitinori Saitou

  Cell stem cell, 2017年10月05日

  
• In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.

  Hiroshi Ohta; Kazuki Kurimoto; Ikuhiro Okamoto; Tomonori Nakamura; Yukihiro Yabuta; Hidetaka Miyauchi; Takuya Yamamoto; Yukiko Okuno; Masatoshi Hagiwara; Kenjiro Shirane; Hiroyuki Sasaki; Mitinori Saitou

  The EMBO journal, 2017年07月03日

  
• Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate.

  Shihori Yokobayashi; Keisuke Okita; Masato Nakagawa; Tomonori Nakamura; Yukihiro Yabuta; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, 2017年06月01日

  
• Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion.

  Arata Honda; Yoshihiro Kawano; Haruna Izu; Narantsog Choijookhuu; Kimiko Honsho; Tomonori Nakamura; Yukihiro Yabuta; Takuya Yamamoto; Yasuhiro Takashima; Michiko Hirose; Tadashi Sankai; Yoshitaka Hishikawa; Atsuo Ogura; Mitinori Saitou

  Scientific reports, 2017年03月28日

  この論文にアクセスする：

  
• Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys.

  Tomonori Nakamura; Yukihiro Yabuta; Ikuhiro Okamoto; Kotaro Sasaki; Chizuru Iwatani; Hideaki Tsuchiya; Mitinori Saitou

  Scientific data, 2017年, 査読有り

  
• In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.

  Yukiko Ishikura; Yukihiro Yabuta; Hiroshi Ohta; Katsuhiko Hayashi; Tomonori Nakamura; Ikuhiro Okamoto; Takuya Yamamoto; Kazuki Kurimoto; Kenjiro Shirane; Hiroyuki Sasaki; Mitinori Saitou

  Cell reports, 2016年12月06日

  この論文にアクセスする：

  
• The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.

  Kotaro Sasaki; Tomonori Nakamura; Ikuhiro Okamoto; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Yasunari Seita; Shinichiro Nakamura; Naoto Shiraki; Tetsuya Takakuwa; Takuya Yamamoto; Mitinori Saitou

  Developmental cell, 2016年10月24日

  
• Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells.

  Kenjiro Shirane; Kazuki Kurimoto; Yukihiro Yabuta; Masashi Yamaji; Junko Satoh; Shinji Ito; Akira Watanabe; Katsuhiko Hayashi; Mitinori Saitou; Hiroyuki Sasaki

  Developmental cell, 2016年10月10日

  
• A developmental coordinate of pluripotency among mice, monkeys and humans.

  Tomonori Nakamura; Ikuhiro Okamoto; Kotaro Sasaki; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Yasunari Seita; Shinichiro Nakamura; Takuya Yamamoto; Mitinori Saitou

  Nature, 2016年09月01日

  
• Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice.

  Chika Yamashiro; Takayuki Hirota; Kazuki Kurimoto; Tomonori Nakamura; Yukihiro Yabuta; So I Nagaoka; Hiroshi Ohta; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, 2016年01月

  
• Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.

  Kotaro Sasaki; Shihori Yokobayashi; Tomonori Nakamura; Ikuhiro Okamoto; Yukihiro Yabuta; Kazuki Kurimoto; Hiroshi Ohta; Yoshinobu Moritoki; Chizuru Iwatani; Hideaki Tsuchiya; Shinichiro Nakamura; Kiyotoshi Sekiguchi; Tetsushi Sakuma; Takashi Yamamoto; Takahide Mori; Knut Woltjen; Masato Nakagawa; Takuya Yamamoto; Kazutoshi Takahashi; Shinya Yamanaka; Mitinori Saitou

  Cell stem cell, 2015年08月06日

  
• SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.

  Tomonori Nakamura; Yukihiro Yabuta; Ikuhiro Okamoto; Shinya Aramaki; Shihori Yokobayashi; Kazuki Kurimoto; Kiyotoshi Sekiguchi; Masato Nakagawa; Takuya Yamamoto; Mitinori Saitou

  Nucleic acids research, 2015年05月19日

  この論文にアクセスする：

  
• Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

  Kazuki Kurimoto; Yukihiro Yabuta; Katsuhiko Hayashi; Hiroshi Ohta; Hiroshi Kiyonari; Tadahiro Mitani; Yoshinobu Moritoki; Kenjiro Kohri; Hiroshi Kimura; Takuya Yamamoto; Yuki Katou; Katsuhiko Shirahige; Mitinori Saitou

  Cell stem cell, 2015年05月07日

  
• Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.

  Bernhard Payer; Michael Rosenberg; Masashi Yamaji; Yukihiro Yabuta; Michiyo Koyanagi-Aoi; Katsuhiko Hayashi; Shinya Yamanaka; Mitinori Saitou; Jeannie T Lee

  Molecular cell, 2013年12月26日

  
• A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.

  Shinya Aramaki; Katsuhiko Hayashi; Kazuki Kurimoto; Hiroshi Ohta; Yukihiro Yabuta; Hiroko Iwanari; Yasuhiro Mochizuki; Takao Hamakubo; Yuki Kato; Katsuhiko Shirahige; Mitinori Saitou

  Developmental cell, 2013年12月09日

  
• Induction of mouse germ-cell fate by transcription factors in vitro.

  Fumio Nakaki; Katsuhiko Hayashi; Hiroshi Ohta; Kazuki Kurimoto; Yukihiro Yabuta; Mitinori Saitou

  Nature, 2013年09月12日

  
• PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.

  Masashi Yamaji; Jun Ueda; Katsuhiko Hayashi; Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Ryuichiro Nakato; Yasuhiro Yamada; Katsuhiko Shirahige; Mitinori Saitou

  Cell stem cell, 2013年03月07日

  
• Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development.

  Kenji Ichiyanagi; Yufeng Li; Toshiaki Watanabe; Tomoko Ichiyanagi; Kei Fukuda; Junko Kitayama; Yasuhiro Yamamoto; Satomi Kuramochi-Miyagawa; Toru Nakano; Yukihiro Yabuta; Yoshiyuki Seki; Mitinori Saitou; Hiroyuki Sasaki

  Genome research, 2011年12月

  
• TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.

  Yukihiro Yabuta; Hiroshi Ohta; Takaya Abe; Kazuki Kurimoto; Shinichiro Chuma; Mitinori Saitou

  The Journal of cell biology, 2011年03月07日

  
• Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells.

  Shinpei Yamaguchi; Kazuki Kurimoto; Yukihiro Yabuta; Hiroyuki Sasaki; Norio Nakatsuji; Mitinori Saitou; Takashi Tada

  Development (Cambridge, England), 2009年12月

  
• Critical function of Prdm14 for the establishment of the germ cell lineage in mice.

  Masashi Yamaji; Yoshiyuki Seki; Kazuki Kurimoto; Yukihiro Yabuta; Mihoko Yuasa; Mayo Shigeta; Kaori Yamanaka; Yasuhide Ohinata; Mitinori Saitou

  Nature genetics, 2008年08月

  
• Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice.

  Kazuki Kurimoto; Yukihiro Yabuta; Yasuhide Ohinata; Mayo Shigeta; Kaori Yamanaka; Mitinori Saitou

  Genes & development, 2008年06月15日

  
• Single-cell cDNA high-density oligonucleotide microarray analysis: detection of individual cell types and properties in complex biological processes.

  Mitinori Saitou; Yukihiro Yabuta; Kazuki Kurimoto

  Reproductive biomedicine online, 2008年01月

  
• [Single-cell analysis for the specification of germ cell fate in mice].

  Yasuhide Ohinata; Kazuki Kurimoto; Yukihiro Yabuta; Yoshiyuki Seki; Mitinori Saitou

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007年12月

  
• Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.

  Yoshiyuki Seki; Masashi Yamaji; Yukihiro Yabuta; Mitsue Sano; Mayo Shigeta; Yasuhisa Matsui; Yumiko Saga; Makoto Tachibana; Yoichi Shinkai; Mitinori Saitou

  Development (Cambridge, England), 2007年07月

  
• Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis.

  Kazuki Kurimoto; Yukihiro Yabuta; Yasuhide Ohinata; Mitinori Saitou

  Nature protocols, 2007年

  
• Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling.

  Yukihiro Yabuta; Kazuki Kurimoto; Yasuhide Ohinata; Yoshiyuki Seki; Mitinori Saitou

  Biology of reproduction, 2006年11月

  
• An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis.

  Kazuki Kurimoto; Yukihiro Yabuta; Yasuhide Ohinata; Yukiko Ono; Kenichiro D Uno; Rikuhiro G Yamada; Hiroki R Ueda; Mitinori Saitou

  Nucleic acids research, 2006年

  
• Folding pathway mediated by an intramolecular chaperone: intrinsically unstructured propeptide modulates stochastic activation of subtilisin.

  Ezhilkani Subbian; Yukihiro Yabuta; Ujwal P Shinde

  Journal of molecular biology, 2005年03月25日

  
• Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases.

  Ezhilkani Subbian; Yukihiro Yabuta; Ujwal Shinde

  Biochemistry, 2004年11月16日

  
• Directed biosynthesis of fluorinated pseurotin A, synerazol and gliotoxin.

  Yasuhiro Igarashi; Yukihiro Yabuta; Akira Sekine; Kiyonaga Fujii; Ken-Ichi Harada; Tsutomu Oikawa; Mayumi Sato; Tamotsu Furumai; Toshikazu Oki

  The Journal of antibiotics, 2004年11月

  
• Determination of the absolute configuration of synerazol.

  Yasuhiro Igarashi; Yukihiro Yabuta; Tamotsu Furumai

  The Journal of antibiotics, 2004年08月

  
• Folding pathway mediated by an intramolecular chaperone. A functional peptide chaperone designed using sequence databases.

  Yukihiro Yabuta; Ezhilkani Subbian; Catherine Oiry; Ujwal Shinde

  The Journal of biological chemistry, 2003年04月25日

  
• Folding pathway mediated by an intramolecular chaperone: dissecting conformational changes coincident with autoprocessing and the role of Ca(2+) in subtilisin maturation.

  Yukihiro Yabuta; Ezhilkani Subbian; Hiroshi Takagi; Ujwal Shinde; Masayori Inouye

  Journal of biochemistry, 2002年01月

  
• Folding pathway mediated by an intramolecular chaperone: propeptide release modulates activation precision of pro-subtilisin.

  Y Yabuta; H Takagi; M Inouye; U Shinde

  The Journal of biological chemistry, 2001年11月30日

  
• Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones.

  H Takagi; M Koga; S Katsurada; Y Yabuta; U Shinde; M Inouye; S Nakamori

  FEBS letters, 2001年11月16日

  
• Folding pathway mediated by an intramolecular chaperone: the structural and functional characterization of the aqualysin I propeptide.

  C Marie-Claire; Y Yabuta; K Suefuji; H Matsuzawa; U Shinde

  Journal of molecular biology, 2001年01月05日

  

MISC

• Generation of human oogonia from induced pluripotent stem cells in vitro

  Chika Yamashiro; Kotaro Sasaki; Yukihiro Yabuta; Yoji Kojima; Tomonori Nakamura; Ikuhiro Okamoto; Shihori Yokobayashi; Yusuke Murase; Yukiko Ishikura; Kenjiro Shirane; Hiroyuki Sasaki; Takuya Yamamoto; Mitinori Saitou

  Obstetrical and Gynecological Survey, 2019年03月01日