宮本 章歳
ミヤモト アキトシ生命科学研究科 高次生命科学専攻認知情報学講座 助教
list
Last Updated :2024/09/02
基本情報
学位
経歴
プロフィール
プロフィール
コツコツと地道に研究しています。
使用言語
ID,URL
J-Global ID
researchmap URL
list
Last Updated :2024/09/02
研究
研究テーマ・研究概要
研究テーマ
革新的超解像イメージング法を用いた脳神経ネットワーク機能の解明研究概要
シナプス伝達の強弱を決めるシナプス可塑性は記憶・学習の基盤である。神経細胞には、シナプスで情報を受け取るスパインと呼ばれる構造があり、スパインの形態がシナプス可塑性を制御する。そこで、我々はIRISを用いて、スパインに局在するタンパク質群の局在を詳細に解析する事で、スパイン形態制御を介したシナプス可塑性制御機構の解明を目指す。
研究キーワード
研究分野
論文
- Protocol to generate fast-dissociating recombinant antibody fragments for multiplexed super-resolution microscopyQianli Zhang; Akitoshi Miyamoto; Naoki WatanabeSTAR Protocols, 2023年09月, 査読有り, 招待有り
- Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopyQianli Zhang; Akitoshi Miyamoto; Shin Watanabe; Takao Arimori; Masanori Sakai; Madoka Tomisaki; Tai Kiuchi; Junichi Takagi; Naoki WatanabeCell Reports Methods, 2022年10月, 査読有り
- Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca2+ Influx via L-Type Ca2+ ChannelsChihiro Hisatsune; Tadayuki Shimada; Akitoshi Miyamoto; Amy Lee; Kanato YamagataThe Journal of Neuroscience, 2021年09月29日, 査読有り
- Bidirectional Control of Synaptic GABA(A)R Clustering by Glutamate and CalciumHiroko Bannai; Fumihiro Niwa; Mark W. Sherwood; Amulya Nidhi Shrivastava; Misa Arizono; Akitoshi Miyamoto; Kotomi Sugiura; Sabine Levi; Antoine Triller; Katsuhiko MikoshibaCELL REPORTS, 2015年12月, 査読有り
- 3PT206 IP_3/Ca^<2+>シグナリングによるGABA作動性シナプスの制御(日本生物物理学会第50回年会(2012年度))Bannai Hiroko; Niwa Fumihiro; Sherwood Mark W.; Arizono Misa; Miyamoto Akitoshi; Sugiura Kotomi; Levi Sabine; Triller Antoine; Mikoshiba Katsuhiko生物物理, 2012年
- Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggsToru Matsu-ura; Hideki Shirakawa; Kenichi G; N. Suzuki; Akitoshi Miyamoto; Kotomi Sugiura; Takayuki Michikawa; Akihiro Kusumi; Katsuhiko MikoshibaScientific Reports, 2019年, 査読有り
- A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation.Akitoshi Miyamoto; Katsuhiko MikoshibaCell Calcium, 2019年, 査読有り, 筆頭著者, 責任著者
- A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patternsJillian P. Casey; Taisei Hirouchi; Chihiro Hisatsune; Bryan Lynch; Raymond Murphy; Aimee M. Dunne; Akitoshi Miyamoto; Sean Ennis; Nick van der Spek; Bronagh O'Hici; Katsuhiko Mikoshiba; Sally Ann LynchJOURNAL OF NEUROLOGY, 2017年07月, 査読有り
- Probes for manipulating and monitoring IP3.Akitoshi Miyamoto; Katsuhiko MikoshibaCell Calcium, 2016年, 査読有り, 招待有り, 筆頭著者
- Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope.Akitoshi Miyamoto; Kotomi Sugiura; Katsuhiko MikoshibaCell Calcium, 2016年, 査読有り, 筆頭著者
- Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5Ryo Ushioda; Akitoshi Miyamoto; Michio Inoue; Satoshi Watanabe; Masaki Okumura; Ken-ichi Maegawa; Kaiku Uegaki; Shohei Fujii; Yasuko Fukuda; Masataka Umitsu; Junichi Takagi; Kenji Inaba; Katsuhiko Mikoshiba; Kazuhiro NagataPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016年10月, 査読有り, 筆頭著者
- Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptorsHiroko Bannai; Fumihiro Niwa; Mark W Sherwood; Amulya Nidhi Shrivastava; Misa Arizono; Akitoshi Miyamoto; Kotomi Sugiura; Sabine Lévi; Antoine Triller; Katsuhiko MikoshibaCell Reports, 2015年, 査読有り
- Apoptosis induction-related cytosolic calcium responses revealed by the dual FRET imaging of calcium signals and caspase-3 activation in a single cellAkitoshi Miyamoto; Hiroshi Miyauchi; Takako Kogure; Atsushi Miyawaki; Takayuki Michikawa; Katsuhiko MikoshibaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015年04月, 査読有り, 筆頭著者
- Optimal microscopic systems for long-term imaging of intracellular calcium using a ratiometric genetically-encoded calcium indicatorAkitoshi Miyamoto; Hiroko Bannai; Takayuki Michikawa; Katsuhiko MikoshibaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013年05月, 査読有り, 筆頭著者
- Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor StimulationMisa Arizono; Hiroko Bannai; Kyoko Nakamura; Fumihiro Niwa; Masahiro Enomoto; Toru Matsu-ura; Akitoshi Miyamoto; Mark W. Sherwood; Takeshi Nakamura; Katsuhiko MikoshibaSCIENCE SIGNALING, 2012年04月, 査読有り
- Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calciumTadashi Shinohara; Takayuki Michikawa; Masahiro Enomoto; Jun-Ichi Goto; Miwako Iwai; Toru Matsu-ura; Haruka Yamazaki; Akitoshi Miyamoto; Akio Suzuki; Katsuhiko MikoshibaPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011年09月, 査読有り
MISC
- Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulationM. Arizono; H. Bannai; K. Nakamura; F. Niwa; M. Enomoto; T. Matsu-ura; A. Miyamoto; M. W. Sherwood; T. Nakamura; K. MikoshibaJOURNAL OF NEUROCHEMISTRY, 2012年10月
- Mechanistic basis of the bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calciumTakayuki Michikawa; Tadashi Shinohara; Masahiro Enomoto; Jun-Ichi Goto; Miwako Iwai; Toru Matsu-ura; Haruka Yamazaki; Akitoshi Miyamoto; Akio Suzuki; Katsuhiko MikoshibaNEUROSCIENCE RESEARCH, 2011年
- Astrocyte processes exhibit confined mGluR5 diffusion to maintain high mGluR5 density and high sensitivity to mGluR agonistMisa Arizono; Takeshi Nakamura; Kyoko Nakamura; Masahiro Enomoto; Akitoshi Miyamoto; Hiroko Bannai; Katsuhiko MikoshibaNEUROSCIENCE RESEARCH, 2010年
